References on the Administration of Aldosterone Using
ALZET^® Osmotic Pumps

P8600 de Seigneux,S., Nielsen,J., Olesen,E.T.B., Dimke,H., Kwon,T.H., Frokiaer,J., Nielsen,S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; 6,7,8 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

P8577 Grossmann,C., Krug,A.W., Freudinger,R., Mildenberger,S., Voelker,K., Gekle,M. Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am.J.Physiol Endocrinol.Metab 2007/6; 292(-6-):E1790-E1800. >>> Aldosterone; dexamethasone; DMSO; Rat; 2ML1; 6 days; Controls received mp w/ vehicle; functionality of mp verified by plasma concentrations; replacement therapy (adrenalectomy); animal info (male, Munich-Wistar, 200-250 grams); endocrinology.

P8551 Frindt,G., Ergonul,Z., Palmer,L.G. Na channel expression and activity in the medullary collecting duct of rat kidney. American Journal of Physiology-Renal Physiology 2007; 292(-4-):F1190-F1196. >>> Aldosterone; PEG 300; SC; Rat; 2002; 6-7 days; Animal info (male, female, Sprague-Dawley, 150-170 grams).

P8537 Kim,Y.H., Pech,V., Spencer,K.B., Beierwaltes,W.H., Everett,L.A., Green,E.D., Shin,W., Verlander,J.W., Sutliff,R.L., Wall,S.M. Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice. American Journal of Physiology-Renal Physiology 2007; 293(-4-):F1314-F1324. >>> Aldosterone; Saline; DMSO; SC; Mice; 7 days; Controls received mp w/ vehicle; functionality of mp verified by serum aldosterone levels; 2.4% DMSO used.

P8517 Hunter,R.G., Bellani,R., Bloss,E., Costa,A., Romeo,R.D., McEwen,B.S. Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala. Brain Research 2007; 1152(--):234-240. >>> Aldosterone; RU28362; Propylene glycol; SC; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); animal info (male, Sprague-Dawley, 21 or 70 days old).

P8440 Shibata,S., Nagase,M., Yoshida,S., Kawachi,H., Fujita,T. Podocyte as the target for aldosterone - Roles of oxidative stress and Sgk1. Hypertension 2007; 49(-2-):355-364. >>> Aldosterone; SC; Rat; 2004; 2,4,6 weeks; Controls received no treatment; replacement therapy (uninephrectomy); cardiovascular; animal info (Sprague-Dawley, 300-350 g); nephrology.

P8398 Peng,H.M., Carretero,O.A., Liao,T.D., Peterson,E.L., Rhaleb,N.E. Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension 2007; 49(-3-):695-703. >>> Aldosterone; peptide, Ac-SDKP; SC; Rat; 2ML4; 6 weeks; Controls received sham treatment; replacement therapy (left kidney removed); pumps replaced; half-life (pg. 700) 4.5 minutes in the circulation (Ac-SDKP); cardiovascular; peptides; animal info (male, Sprague-Dawley, 10 wks old, 325-350g.).

P8380 Leopold,J.A., Dam,A., Maron,B.A., Scribner,A.W., Liao,R., Handy,D.E., Stanton,R.C., Pitt,B., Loscalzo,J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nature Medicine 2007; 13(-2-):189-197. >>> Aldosterone; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels and systolic BP; cardiovascular; animal info (male, C3H wt; G6PD-deficient, 12-16 wks old).

P8248 Nielsen,J., Kwon,T.H., Frokiaer,J., Knepper,M.A., Nielsen,S. Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade. American Journal of Physiology-Renal Physiology 2007; 292(-1-):F382-F394. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7, 10 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; dose-response (pg F383); no stress (see pg F384); post op. care (bupivacaine); animal info (male, Sprague-Dawley, 190-210g); 25% DMSO.

P8151 Hirono,Y., Yoshimoto,T., Suzuki,N., Sugiyama,T., Sakurada,M., Takai,S., Kobayashi,N., Shichiri,M., Hirata,Y. Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: The possible role of local renin-angiotensin system. Endocrinology 2007; 148(-4-):1688-1696. >>> Aldosterone, D-; Water, distilled; propylene glycol; ethanol; SC; Rat; 2004; 3 weeks; Blood pressure taken; replacement therapy (uninephrectomy); cardiovascular; animal info (7 weeks old, male, Sprague-Dawley); 9% ethanol used.

P8449 Goodwin,K.D., Ahokas,R.A., Bhattacharya,S.K., Sun,Y., Gerling,I.C., Weber,K.T. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. American Journal of the Medical Sciences 2006; 332(-2-):73-78. >>> Aldosterone; calcitriol; SC; Rat; 2004; 2ML4; 4 weeks; Controls received no treatment; replacement therapy (uninephrectomy); cardiovascular; animal info (male, Sprague-Dawley, 8 wks old).

P8376 Rahman,M., Nishiyama,A., Guo,P., Nagai,Y., Zhang,G.X., Fujisawa,Y., Fan,Y.Y., Kimura,S., Hosomi,N., Omori,K., Abe,Y., Kohno,M. Effects of adrenomedullin on cardiac oxidative stress and collagen accumulation in aldosterone-dependent malignant hypertensive rats. Journal of Pharmacology and Experimental Therapeutics 2006; 318(-3-):1323-1329. >>> Aldosterone; adrenomedullin; Ethanol; SC; Rat; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, SHR, Wistar-Kyoto, 10 wks old, 240-295g.); 0.5% EtOH.

P8358 Klein,J.D., Kozlowski,S., Antoun,T.A., Sands,J.M. Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney. Journal of Membrane Biology 2006; 212(-2-):139-144. >>> Aldosterone; Rat; 14 days; Replacement therapy (adrenalectomy, STZ-induced diabetes mellitus); animal info (male, Sprague-Dawley, 100-150 grams); endocrinology.

P8355 rias-Loza,P.A., Hu,K., Schaefer,A., Bauersachs,J., Quaschning,T., Galle,J., Jazbutyte,V., Neyses,L., Ertl,G., Fritzemeier,K.H., Hegele-Hartung,C., Pelzer,T. Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats. Hypertension 2006; 48(-5-):994-1001. >>> Aldosterone; SC; Rat; ; Controls received sham treatment; replacement therapy (ovariectomy, uninephrectomy); cardiovascular; animal info (female, Wistar, 250-300 grams).

P8122 Fukushima,K., Haneda,S., Takahashi,K.I., Gawa,H., Watanabe,K., Funayama,Y., Shibata,C., Sasaki,I. Molecular analysis of colonic transformation in the ileum after total colectomy in rats. Surgery 2006; 140(-1-):93-99. >>> Aldosterone, D-; PEG 400; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 8 wk old, 250-300g.); gene expression.

P8100 Nehme,J., Mercier,N., Labat,C., Benetos,A., Safar,M.E., Delcayre,C., Lacolley,P. Differences between cardiac and arterial fibrosis and stiffness in aldosterone-salt rats: Effect of eplerenone. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 2006; 7(-1-):31-39. >>> Aldosterone, D-; SC; Rat; 2004; 28 days; Controls received mp w/ physiological serum; replacement therapy (uninephrectomy); cardiovascular; animal info (male, Sprague-Dawley, 8 wk old, 300g.).

P7927 Tiwari,S., Packer,R.K., Hu,X.Q., Sugimura,Y., Verbalis,J.G., Ecelbarger,C.A. Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. American Journal of Physiology-Renal Physiology 2006; 291(-1-):F49-F57. >>> Vasopressin, 1-desamino-8-D-arginine; aldosterone; SC; Rat; 2002; ; Blood pressure taken; replacement therapy (adrenalectomy); multiple pumps per animal (2); animal info (male, Sprague-Dawley, 275 grams, ADX); dDAVP; one pump for each drug.

P7841 Buss,S.J., Backs,J., Kreusser,M.M., Hardt,S.E., Maser-Gluth,C., Katus,H.A., Haass,M. Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats. Endocrinology 2006; 147(-5-):2526-2534. >>> Aldosterone, D-; Rat; 2004; 28 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; cardiovascular; animal info (male, Wistar, 200g.).

P7809 Ma,J., Weisberg,A., Griffin,J.P., Vaughan,D.E., Fogo,A.B., Brown,N.J. Plasminogen activator inhibitor-1 deficiency protects against aldosterone- induced glomerular injury. Kidney International 2006; 69(-6-):1064-1072. >>> Aldosterone, D-; DMSO; SC; Mice; 2004; 12 weeks; Controls received mp w/ vehicle; replacement therapy (uninephrectomy); long-term study; pumps replaced every 4 weeks; cardiovascular; animal info (male, C57BL/6J wt or PAI-1(-/-), 8-10 wk old, 27g.); 3.6% DMSO; nephrology.

P7777 Fan,Y.Y., Baba,R., Nagai,Y., Miyatake,A., Hosomi,N., Kimura,S., Sun,G.P., Kohno,M., Fujita,M., Abe,Y., Nishiyama,A. Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; Renoprotective effects of an ultrahigh dose of olmesartan. HYPERTENSION RESEARCH 2006; 29(-3-):169-178. >>> Aldosterone; Ethanol; SC; Rat; 2002; 3, 6 weeks; Controls received mp w/ vehicle; replacement therapy (uninephrectomy); long-term study; pumps replaced every 2 weeks; cardiovascular; animal info (male, Sprague-Dawley, 162-184g.); 2% ETOH.

P7743 Wang,W.D., Li,C.L., Summer,S.N., Falk,S., Cadnapaphornchai,M.A., Chen,Y.C., Schrier,R.W. Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiency. American Journal of Physiology-Renal Physiology 2006; 290(-5-):F1135-F1142. >>> Aldosterone; IP; Rat; 2ML4; 12 days; Replacement therapy (adrenalectomy); animal info (male, Wistar, 160-180g.).

P7732 Nielsen,J., Kwon,T.H., Frokiaer,J., Knepper,M.A., Nielsen,S. Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD. American Journal of Physiology-Renal Physiology 2006; 290(-5-):F1222-F1233. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7 days; Controls received no treatment; animal info (male, wistar, 190-210g.); 25% DMSO.

P7667 Geerling,J.C., Engeland,W.C., Kawata,M., Loewy,A.D. Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite. Journal of Neuroscience 2006; 26(-2-):411-417. >>> Aldosterone; Saline; ethanol; IP; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; replacement therapy (bilateral adrenalectomy); animal info (male, Sprague-Dawley, 275-325 g); 1 % ETOH.

P7513 Vidal,A., Sun,Y., Bhattacharya,S.K., Ahokas,R.A., Gerling,I.C., Weber,K.T. Calcium paradox of aldosteronism and the role of the parathyroid glands. American Journal of Physiology-Heart and Circulatory Physiology 2006; 290(-1-):H286-H294. >>> Aldosterone; Rat; 1, 2, 4, 6 weeks; Controls received no treatment; replacement therapy (uninephrectomy, parathyroidectomy); cardiovascular; animal info (male, Sprague-Dawley, 9 wk old).

P7466 Nielsen,J., Kwon,T.H., Praetorius,J., Frokiaer,J., Knepper,M.A., Nielsen,S. Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus. American Journal of Physiology-Renal Physiology 2006; 290(-2-):F438-F449. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7 days; Controls received no treatment; animal info (male, Wistar, 180 g); 25% DMSO.

P8063 Chen,Y.C., Cadnapaphornchai,M.A., Summer,S.N., Falk,S., Li,C.L., Wang,W.D., Schrier,R.W. Molecular mechanisms of impaired urinary concentrating ability in glucocorticoid-deficient rats. Journal of the American Society of Nephrology 2005; 16(-10-):2864-2871. >>> Aldosterone; IP; Rat; 2ML4; 11 days; Controls received mp w/ agent plus SC injections of dexamethasone; replacement therapy (adrenalectomy); animal info (male, Sprague-Dawley, 175-200g.); nephrology.

P7628 Perrier,R., Richard,S., Sainte-Marie,Y., Rossier,B.C., Jaisser,F., Hummler,E., Benitah,J.P. A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice. JOURNAL OF PHYSIOLOGY-LONDON 2005; 569(-1-):153-162. >>> RU-28318; aldosterone; Saline; SC; Mice (transgenic); 2004; 3 weeks; Controls received mp w/ serum.

P7445 Fukushima,K., Funayama,Y., Yonezawa,H., Takahashi,K., Haneda,S., Suzuki,T., Sasano,H., Naito,H., Shibata,C., Krozowski,Z.S., Sasaki,I. Aldosterone enhances 11beta-hydroxysteroid dehydrogenase type 2 expression in colonic epithelial cells in vivo. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2005; 40(-7-):850-857. >>> Aldosterone, D-; PEG 400; SC; Rat; 2ML4; 1,2,4 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone concentration; comparison of sodium-depleted diet vs.mp; animal info (male, Sprague-Dawley, 250-300 g).

P7225 Cassis,L.A., Helton,M.J., Howatt,D.A., King,V.L., Daugherty,A. Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. British Journal of Pharmacology 2005; 144(-3-):443-448. >>> Aldosterone; angiotensin II; Propylene glycol; saline; ethanol; water; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; replacement therapy (hyperlipidemic); no stress (see pg. 444); cardiovascular; 9% ethanol.

P7224 Chhokar,V.S., Sun,Y., Bhattacharya,S.K., Ahokas,R.A., Myers,L.K., Xing,Z.Q., Smith,R.A., Gerling,I.C., Weber,K.T. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation 2005; 111(-7-):871-878. >>> Aldosterone; SC; Rat; 1,2,4,6 weeks; Controls received no treatment; replacement therapy (uninephrectomy); no stress (see pg. 873); cardiovascular.

P7177 Crowley,S.D., Gurley,S.B., Oliverio,M.I., Pazmino,A.K., Griffiths,R., Flannery,P.J., Spurney,R.F., Kim,H.S., Smithies,O., Le,T.H., Coffman,T.M. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. Journal of Clinical Investigation 2005; 115(-4-):1092-1099. >>> Aldosterone; dexamethasone; PEG 400; saline, normal; SC; Mice; 2004; ; Replacement therapy (adrenalectomy, nephrectomy).

P7072 Kademian,S.M.E., Bignante,A.E., Lardone,P., McEwen,B.S., Volosin,M. Biphasic effects of adrenal steroids on learned helplessness behavior induced by inescapable shock. Neuropsychopharmacology 2005; 30(-1-):58-66. >>> Aldosterone, D-; Propylene glycol; SC; Rat; 2001; 3 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy).

P6737 Sato,S., Fukushima,K., Naito,H., Funayama,Y., Suzuki,T., Sasano,H., Krozowski,Z., Shibata,C., Sasaki,I. Induction of 11 beta-hydroxysteroid dehydrogenase type 2 and hyperaldosteronism are essential for enhanced sodium absorption after total colectomy in rats. Surgery 2005; 137(-1-):75-84. >>> Aldosterone; PEG 400; SC; Rat; 2ML4; 1,2,4 weeks; Aldo plasma levels taken; replacement therapy (colectomy); no stress (see pg. 76).

P7129 Liu,Y., Imai,H., Sadamatsu,M., Tsunashima,K., Kato,N. Cytokines participate in neuronal death induced by trimethyltin in the rat hippocampus via type II glucocorticoid receptors. NEUROSCIENCE RESEARCH 2004; 50(--):209-217. >>> Aldosterone; dexamethasone; SC; Rat; 11,21 days; Controls received sham operation; replacement therapy (adrenalectomy).

P7056 Fukushima,K., Naito,H., Funayama,Y., Yonezawa,H., Haneda,S., Shibata,C., Sasaki,I. In vivo induction of prostasin mRNA in colonic epithelial cells by dietary sodium depletion and aldosterone infusion in rats. Journal of Gastroenterology 2004; 39(-10-):940-947. >>> Aldosterone, D-; PEG 400; SC; Rat; 2ML4; 1,2,4 weeks; Controls received mp w/ vehicle, or sodium-depleted diet; no stress (see pg. 941).

P7033 Iglarz,M., Touyz,R.M., Viel,E.C., Amiri,F., Schiffrin,E.L. Involvement of oxidative stress in the profibrotic action of aldosterone - Interaction with the renin-angiotensin system. American Journal of Hypertension 2004; 17(-7-):597-603. >>> Aldosterone, D-; SC; Rat; 2002; 6 weeks; Controls received no treatment; functionality of mp verified by systolic BP; pumps replaced every two weeks; no stress (pg. 599); cardiovascular.

P6847 Gomez-Sanchez,E.P., Ahmad,N., Romero,D.G., Gomez-Sanchez,C.E. Origin of aldosterone in the rat heart. Endocrinology 2004; 145(-11-):4796-4802. >>> Aldosterone; Rat; 8 days; Replacement therapy (adrenalectomy); cardiovascular.

P6692 Sam,F., Xie,Z.L., Ooi,H., Kerstetter,D.L., Colucci,W.S., Singh,M., Singh,K. Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion. American Journal of Hypertension 2004; 17(-2-):188-193. >>> Aldosterone; Saline; SC; Mice (knockout); 4 weeks; 7 days; Controls received mp w/ vehicle; blood pressure taken; pump model not listed.

P6649 Keidar,S., Kaplan,M., Pavlotzky,E., Coleman,R., Hayek,T., Hamoud,S., Aviram,M. Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development - A possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Circulation 2004; 109(-18-):2213-2220. >>> Aldosterone; Saline; ethanol; Mice; 1002; 1,2,4 weeks; Controls received mp w/ vehicle; dose-response (table 1); cardiovascular.

P6605 Gertner,R.A., Klein,J.D., Bailey,J.L., Kim,D.U., Luo,X.H., Bagnasco,S.M., Sands,J.M. Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor. Journal of the American Society of Nephrology 2004; 15(-3-):558-565. >>> Aldosterone; spironolactone; dexamethasone; Saline; DMSO; SC; Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy);<10% DMSO used.

P6544 Buffin-Meyer,B., Younes-Ibrahim,M., El Mernissi,G., Cheval,L., Marsy,S., Grima,M., Girolami,J.P., Doucet,A. Differential regulation of collecting duct Na+,K+-ATPase and K+ excretion by furosemide and piretanide: Role of bradykinin. Journal of the American Society of Nephrology 2004; 15(-4-):876-884. >>> Furosemide; dexmethasone; diretanide; aldosterone; Hoe 140; Saline; SC; IP; Rat; 6 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); solution was a pH 9.0; a third group was adrenalectomized and given dexamethasone and aldosterone by a SC ALZET pump; in a fifth set of experiments Hoe140 was infused SC.

P6529 Juknevicius,I., Segal,Y., Kren,S., Lee,R., Hostetter,T.H. Effect of aldosterone on renal transforming growth factor-beta. American Journal of Physiology-Renal Physiology 2004; 286(-6-):F1059-F1062. >>> Aldosterone; Saline; SC; Rat; 3 days; Controls received mp w/ vehicle; blood pressure and aldosterone plasma levels taken; pump model not listed.

P6505 Frindt,G., Palmer,L.G. Na channels in the rat connecting tubule. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F669-F674. >>> Aldosterone; PEG 300; SC; Rat; 2002; 1 week.

P6490 Michel,F., Ambroisine,M.L., Duriez,M., Delcayre,C., Levy,B.I., Silvestre,J.S. Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway. Circulation 2004; 109(-16-):1933-1937. >>> Aldosterone; SC; Mice; 2004; 21 days; Controls received no treatment; cardiovascular; ischemia (cardiac).

P6479 Nishiyama,A., Yao,L., Nagai,Y., Miyata,K., Yoshizumi,M., Kagami,S., Kondo,S., Kiyomoto,H., Shokoji,T., Kimura,S., Kohno,M., Abe,Y. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004; 43(-4-):841-848. >>> Aldosterone; Ethanol; SC; Rat; 2002; 6 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular.

P6393 Bhargava,A., Wang,J., Pearce,D. Regulation of epithelial ion transport by aldosterone through changes in gene expression. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2004; 217(-1-2-):189-196. >>> Aldosterone; SC; Rat; 24 hours; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); half-life (p. 192), 20 minutes; pump model not listed.

R0201 Sun,Y., Weber,K.T. RAS and connective tissue in the heart. INTERNATIONAL JOURNAL OF BIOCHEMISTRY&CELL BIOLOGY 2003; 35(-6-):919-931. >>> Angiotensin II; aldosterone; Rat; 3 weeks; Replacement therapy (uninephrectomy); cardiovascular.

P6724 Park,Y.M., Park,M.Y., Suh,Y.L., Park,J.B. NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats. Biochemical and Biophysical Research Communications 2003; 313(-3-):812-817. >>> Aldosterone; Saline; SC; 2002; 6 weeks; Controls received mp w/ vehicle; blood pressure taken; pumps replaced every two weeks; cardiovascular.

P6122 Ahokas,R.A., Warrington,K.J., Gerling,I.C., Sun,Y., Wodi,L.A., Herring,P.A., Lu,L., Bhattacharya,S.K., Postlethwaite,A.E., Weber,K.T. Aldosteronism and peripheral blood mononuclear cell activation - A neuroendocrine-immune interface. Circulation Research 2003; 93(-10-):E124-E135. >>> Aldosterone; SC; Rat; 1-4 weeks; Pump model not stated.

P6120 Krug,A.W., Papavassiliou,F., Hopfer,U., Ullrich,K.J., Gekle,M. Aldosterone stimulates surface expression of NHE3 in renal proximal br ush borders. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2003; 446(-4-):492-496. >>> Aldosterone; dexamethasone; SC; Rat; 2ML1; 5 days; Functionality of mp verified by aldosterone plasma levels; replacement therapy (adrenalectomy).

P6117 Wang,H., Huang,B.S., Leenen,F.H.H. Brain sodium channels and ouabainlike compounds mediate central aldosterone-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2003; 285(-6-):H2516-H2523. >>> Aldosterone; benzamil; CSF, artificial; CSF/CNS; Rat; 2ML2; 14 days; Cardiovascular.

P6111 Rubera,I., Loffing,J., Palmer,L.G., Frindt,G., Fowler-Jaeger,N., Sauter,D., Carroll,T., McMahon,A., Hummler,E., Rossier,B.C. Collecting duct-specific gene inactivation ofαENaC in the mouse kidney does not impair sodium and potassium balance. Journal of Clinical Investigation 2003; 112(-4-):554-565. >>> Aldosterone; PEG 300; SC; Mice; 1002; 6 days.

P6083 Turban,S., Wang,X.Y., Knepper,M.A. Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO. American Journal of Physiology-Renal Physiology 2003; 285(-5-):F843-F851. >>> Angiotensin II; aldosterone; L-NAME; Acetic acid; DMSO; saline; water; SC; Rat; 2001; 2ML1; 7 days; Controls received mp w/ vehicle; peptides; angiotensin II dissolved in acetic acid; albo dissolved in 30% DMSO/saline; L-NAME dissolved in water.

P6044 Ma,L.J., Yang,H.C., Gaspert,A., Carlesso,G., Barty,M.M., Davidson,J.M., Sheppard,D., Fogo,A.B. Transforming growth factor-b-dependent and -independent pathways of induction of tubulointerstitial fibrosis in b6-/- mice. American Journal of Pathology 2003; 163(-4-):1261-1273. >>> Angiotensin II; aldosterone; IP; Mice (knockout); 1002; 2 weeks; Comparison of aldo pellets vs. IP mp; peptides.

P6034 Krug,A.W., Grossmann,C., Schuster,C., Freudinger,R., Mildenberger,S., Govindan,M.V., Gekle,M. Aldosterone stimulates epidermal growth factor receptor expression. Journal of Biological Chemistry 2003; 278(-44-):43060-43066. >>> Aldosterone; SC; Rat; 2ML1; 1 week; Controls received mp w/ vehicle; aldosterone plasma levels taken; replacement therapy (adrenalectomy).

P6032 Lim,W.C., Park,J.B., Lee,Y.J. Analysis of angiotensin II mediated COX-2 Downregulation in angiotensin II- or aldosterone-infused hypertensive rat. BIOLOGICAL&PHARMACEUTICAL BULLETIN 2003; 26(-8-):1086-1088. >>> Angiotensin II; aldosterone; Saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides.

P5934 Chander,P.N., Rocha,R., Ranaudo,J., Singh,G., Zuckerman,A., Stier,CT Jr  Journal of the American Society of Nephrology 2003; 14(-8-):1990-1997. >>> Angiotensin II; aldosterone; Ethanol; SC; Rat; 2 weeks; Replacement therapy (adrenalectomy); pump model not stated.

P5857 Wotus,C., Engeland,W.C. Differential regulation of adrenal corticosteroids after restriction-induced drinking in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-1-):R183-R191. >>> Aldosterone; Propylene glycol; SC; Rat; ; Controls received mp w/ vehicle; replacement therapy (adrenalectomy).

P5720 Jiang,G.R., Cobbs,S., Klein,J.D., O'Neill,W.C. Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle. Hypertension 2003; 41(-5-):1131-1135. >>> Aldosterone; DMSO; saline; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; serum aldosterone levels checked; replacement therapy (adrenalectomy); cardiovascular; 10% DMSO used.

P5650 Neves,M.F., Virdis,A., Schiffrin,E.L. Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism. Journal of Hypertension 2003; 21(-1-):189-198. >>> Angiotensin II; Aldosterone, d-; Saline; SC; Rat; 2002; 2 weeks; Cardiovascular.

R0157 Burlew,B.S., Weber,K.T. Cardiac fibrosis as a cause of diastolic dysfunction. Herz 2002; 27(--):92-98. >>> Aldosterone; Rat; ; Controls received no treatment/unoperated; replacement therapy (uninephrectomy); cardiovascular.

P6707 Lacolley,P., Labat,C., Pujol,A., Delcayre,C., Benetos,A., Safar,M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats. Circulation 2002; 106(-22-):2848-2853. >>> Aldosterone; Rat; 4 weeks; Replacement therapy (uninephrectomy); no stress (see pg.2849); cardiovascular.

P6590 Rocha,R., Martin-Berger,C.L., Yang,P.C., Scherrer,R., Delyani,J., McMahon,E. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 2002; 143(-12-):4828-4836. >>> Angiotensin II; aldosterone, D-; Saline; ethanol; SC; Rat; 2004; 3 weeks; Controls received mp w/ vehicle (saline); functionality of mp verified by plasma levels; replacement therapy (adrenalectomy); cardiovascular; peptides; 2% ethanol for d-aldo.

P6586 De Angelis,N., Fiordaliso,J., Latini,R., Calvillo,L., Funicello,M., Gobbi,M., Mennini,T., Masson,S. Appraisal of the role of angiotensin II and aldosterone in ventricular myocyte apoptosis in adult normotensive rat. Journal of Molecular and Cellular Cardiology 2002; 34(-12-):1655-1665. >>> Angiotensin II, human synthetic; aldosterone, d-; Acetic acid; saline; ethanol; SC; Rat; 2001, 2002; 10 days; 3,6,8,9,24 hours; Controls received mp w/ vehicle; cardiovascular; peptides.

P6144 Kwon,T.H., Nielsen,J., Masilamani,S., Hager,H., Knepper,M.A., Frokiaer,J., Nielsen,S. Regulation of collecting duct AQP3 expression: response to mineralocor ticoid. American Journal of Physiology-Renal Physiology 2002; 283(-6-):F1403-F1421. >>> Aldosterone; dexamethasone; DMSO; saline; SC; Rat; 2002; 10 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P5841 Ohara,M., Cadnapaphornchai,M.A., Summer,S.N., Falk,S., Yang,J.H., Togawa,T., Schrier,R.W. Effect of mineralocorticoid deficiency on ion and urea transporters and aquaporin water channels in the rat. Biochemical and Biophysical Research Communications 2002; 299(-2-):285-290. >>> Aldosterone; IP; Rat; 2ML4; 9 days; Functionality of mp verified by aldosterone plasma levels; replacement therapy (adrenalectomy).

P5617 Virdis,A., Neves,M.F., Amiri,F., Viel,E., Touyz,R.M., Schiffrin,E.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 2002; 40(-4-):504-510. >>> Angiotensin II; Aldosterone, d-; Saline; SC; Rat; 2 weeks; Antihypertensive; aldosterone plasma levels measured..

P5475 Shade,R.E., Blair-West,J.R., Carey,K.D., Madden,L.J., Weisinger,R.S., Denton,D.A. Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1070-R1078. >>> Angiotensin II; aldosterone; Saline; ethanol; SC; CSF/CNS; Monkey (baboon); 49 days; Controls received mp w/ vehicle; long-term study, pumps replaced every 7 days (6 times); angiotensin II diluted in saline and infused ICV; aldosterone diluted in 10% ethanol in saline and infused SC; some animals implanted w/ 2 pumps.

P5429 Nielsen,J., Kwon,T.H., Masilamani,S., Beutler,K., Hager,H., Nielsen,S., Knepper,M.A. Sodium transporter abundance profiling in kidney: effect of spironolactone. American Journal of Physiology-Renal Physiology 2002; 283(-5-):F923-F933. >>> Dexamethasome; aldosterone, D-; DMSO; saline, sterile; SC; Rat; 2002; 10 days; Replacement therapy (adrenalectomy).

P5419 Rocha,R., Rudolph,A.E., Frierdich,G.E., Nachowiak,D.A., Kekec,B.K., Blomme,E.A.G., McMahon,E.G., Delyani,J.A. Aldosterone induces a vascular inflammatory phenotype in the rat heart. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-5-):H1802-H1810. >>> Aldosterone, D-; Propylene glycol; ethanol; water, distilled; SC; Rat; 2002; 1, 2, or 4 weeks; Controls received mp w/ vehicle; cardiovascular; vehicle consisted of 87% PG, 9% ethanol and 4% d H20.

P5416 Tostes,R.C.A., Touyz,R.M., He,G., Chen,X., Schiffrin,E.L. Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clinical Science 2002; 103(-Suppl. 48-):25S-30S. >>> Aldosterone; Saline; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle.

P5394 Kalman,B.A., Spencer,R.L. Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain. Endocrinology 2002; 143(-11-):4184-4195. >>> Aldosterone; RU-28362; Propylene glycol; SC; Rat; 2001; 5 days; Replacement therapy (adrenalectomy); agents infused together in the same pump or in separate pumps.

P5263 Hou,J., Speirs,H.J., Seckl,J.R., Brown,R.W. Sgk1 gene expression in kidney and its regulation by aldosterone: spatio-temporal heterogeneity and quantitative analysis. J Am.Soc.Nephrol. 2002/5; 13(-5-):1190-1198. >>> Aldosterone; Saline; Ethanol; SC; Mice; 1007D; 6 or 21 days; Controls received mp w/ vehicle; aldosterone plasma levels checked at the end of the experiment; replacement thrapy (adrenalectomy); dose-response (p.1192); comparison of sc injections vs. mp; pumps replaced every 7 days; 2% ethanol in vehicle used.

P5216 Park,J.B., Schiffrin,E.L. Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused r ats: Role of endothelin-1. American Journal of Hypertension 2002; 15(--):164-169. >>> Aldosterone; Saline; SC; Rat; 2002; 6 weeks; Controls received mp w/ vehicle; pumps replaced every 2 weeks; cardiovascular.

P5211 van Acker,S.A., Oitzl,M.S., Fluttert,M.F., de Kloet,E.R. Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone. J Neuroendocrinol. 2002/1; 14(-1-):56-63. >>> Aldosterone; IP; Rat; 2002; 10 days; Functionality verified by aldosterone plasma levels; replacement therapy (adrenalectomy); cardiovascular; antihypertensive;.

P5170 Knepper,Mark A., Beutler,Kathleen, Masilamani,Shyama, Nielsen,Jakob, Nielsen,Soren, Wang,Xiao Yan  American Journal of Physiology 2002/4; 282(-4 Part 2-):F577-F584. >>> Aldosterone; Candesartan; SC; Rat; 2ML2; 2 or 4 days; Controls received mp w/ vehicle; candesartan is an Angiotensin II type 1 receptor blocker; animals received aldosterone for 4 days or candesartan for 2 days.

P5096 Ornellas,D.S., Nascimento,D.S., Christoph,D.H., Guggino,W.B., Morales,M.M. Aldosterone and high-NaCl diet modulate ClC-2 chloride channel gene expression in rat kidney. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2002; 444(--):193-201. >>> Aldosterone; rat; 2001; 48 hours; controls received sham surgery; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy p. 194);.

P4952 Park,J.B., Schiffrin,E.L. ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension 2001; 37(--):1444-1449. >>> Aldosterone; Saline; SC; rat; 2002; 6 weeks; controls received mp w/ vehicle; functionality of mp verified by systolic BP measurement; dose response (graph p. 1446); long-term study, pumps replaced every 2 weeks; cardiovascular; mineralocorticoid hypertension;.

P4939 Bailey,M.A., Unwin,R.J., Shirley,D.G. In vivo inhibition of renal 11-beta-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption. Clinical Science 2001; 101(--):195-198. >>> Aldosterone; Dexamethasone; SC; rat; 2002; 8-12; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy p.195); "the plasma concentration of aldosterone achieved via osmotic minipump is just suficient to maintain the rats in good health without causing over-stimulation." p. 197; mineralocorticoids.

P4929 Imai,H., Nishimura,T., Sadamatsu,M., Liu,Y., Kabuto,M., Kato,N. Type II glucocorticoid receptors are involved in neuronal death and astrocyte activation induced by trimethyltin in the rat hippocampus. Experimental Neurology 2001; 171(--):22-28. >>> Dexamethasone; Aldosterone; SC; rat; 21 days; controls received sham surgery; replacement therapy (adrenalectomy); corticosterone pellets also used;.

P4890 Planas,J.M., Garriga,C., Planas,J.M., Moreto,M. Aldosterone mediates the changes in hexose transport induced by low sodium intake in chicken distal intestine. JOURNAL OF PHYSIOLOGY-LONDON 2001; 535(-1-):197-205. >>> Aldosterone; Propylene glycol; SC; bird (chicken); 2002; 14 days; functionality of mp verified by serum aldosterone, renin levels; dose-response (fig 1 col 7 p. 535.1).

P4867 Wickman,A., Andersson,I.J.L., Jia,J., Hedin,L., Bergstrom,G. Endothelial nitric oxide synthase protein is reduced in the renal medulla of two-kidney, one-clip hypertensive rats. Journal of Hypertension 2001; 19(--):1665-1673. >>> Angiotensin II; Aldosterone; Saline; IP; rat; 7 days; controls received mp w/ vehicle; functionality of mp verified by mean arterial pressure, plasma aldosterone assay; dose response (text p. 1669); peptides; Angiotensin II given in first experiment, aldosterone administered in the second;.

P5260 Shigaev,A., Asher,C., Latter,H., Garty,H., Reuveny,E. Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. Am.J Physiol Renal Physiol 2000/4; 278(-4-):F613-F619. >>> Aldosterone; PEG 300; SC; Rat; 2001; ; Funtionality verified by aldosterone plasma levels.

P4041 Saito,T., Ishikawa,S.-E., Ando,F, Higashiyama,M, Nagasaka,S, Sasaki,S., Saito,T. Vasopressin-dependent upregulation of aquaporin-2 gene expression in glucocorticoid-deficient rats.. Am.J.Physiological.Renal Physiol. 2000; 279(--):F502-F508. >>> Aldosterone; Dexamethasone;; SC;; rat;; 2ML4;; 7 days;; Controls received mp with Aldosterone or Dexamethasone; replacement therapy (adrenalectomy); glucocorticoid;.

P5592 Rocha,R., Chander,P.N., Zuckerman,A., Stier,C.T.,Jr. Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension 1999/1; 33(-Pt 2-):232-237. >>> Aldosterone; Ethanol; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by aldosterone plasma levels; 5% ethanol vehicle used.

P5305 Gomez-Sanchez,E.P., Gomez-Sanchez,C.E. Maternal hypertension and progeny blood pressure: role of aldosterone and 11beta-HSD. Hypertension 1999/6; 33(-6-):1369-1373. >>> Aldosterone; Hydroxyprogesterone, 11a; Carbenolone; SC; CSF/CNS; Rat (pregnant); 2002; 2004; 14, 28 days; Controls received mp w/ vehicle; stress/adverse reaction (p.1370); seroma around pump assembly in systemic carbenolone and hydroxyprogesterone high dose groups; some pumps became disconnected from cannula; glucocorticoids; comparison of sc vs. icv infusion.

P5287 Smeda,J., Vasdev,S., King,S.R. Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. J Pharmacol Exp.Ther 1999/11; 291(-2-):569-575. >>> Aldosterone; PEG 300; SC; Rat; 6 weeks; Controls received mp w/ vehicle; functionality of mp verified by aldosterone plasma levels; cardiovascular; ischemia (cerebral).

P5286 Robert,V., Heymes,C., Silvestre,J.S., Sabri,A., Swynghedauw,B., Delcayre,C. Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis. Hypertension 1999/4; 33(-4-):981-986. >>> Aldosterone; Losartan; Saline; Ethanol; Rat; 2002; 1 month; Controls received mp w/ vehicle; replacement therapy (nephrectomy); cardiovascular.

P4445 Rowland,N.E, Morian,K.R. Roles of aldosterone and angiotensin in maturation of sodium appetite in furosemide-treated rats. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.45) 1999; 276(--):R1453-R1460. >>> Aldosterone; Doca; Angiotensin II;; Propylene glycol; Saline;; SC;; rat;; 2001;; 7 days;; controls received mp w/vehicle; functionality of mp verified by plasma levels; peptides;.

P6313 Wang,D.H., Qiu,J, Hu,Z. Differential Regulation of Angiotensin II Receptor Subtypes in the Adrenal Gland. Hypertension 1998; 32(--):65-70. >>> Aldosterone; Saline; ethanol; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; no stress (see pg. 66); cardiovascular; post op. care (penicillin G).

P5274 Silver,R.B., Choe,H., Frindt,G. Low-NaCl diet increases H-K-ATPase in intercalated cells from rat cortical collecting duct. Am.J Physiol 1998/7; 275(-1 Pt 2-):F94-102. >>> Aldosterone; PEG 300; SC; Rat; 2002; 12-14 days; Functionality of mp verified by aldosterone plasma levels.

P4556 Slight,S.H, Chilakamarri,V.K, Nasr,S, Dhalla,A.K, Ramires,F.J.A., Sun,Y, Ganjam,V.K, Weber,K.T. Inhibition of tissue repair by spironolactone: Role of mineralocorticoids in fibrous tissue formation.. Molecular and Cellular Biochemistry. 1998; 189(--):47-54. >>> Aldosterone;; SC;; rat;; 2002;; 2 weeks;; controls received mp w/vehicle; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy); Glucocorticoids; wound healing;.

P4451 Kim,G.-H, Masilamani,S, Turner,R., Mitchell,C, Wade,J.B, Knepper,M.A  Proc.Natl.Acad.Sci. 1998/11; 95(--):14552-14557. >>> Aldosterone;; DMSO; Saline, isotonic;; SC;; rat;; 2ML2;; 10 days;; controls received mp w/vehicle; functionality of mp verified by plasma levels;.

P4353 Okuhara,D.Y., Beck,S.G. Corticosteroids alter 5-hydroxytryptamine1A receptor-effector pathway in hippocampal subfield CA3 pyramidal cells. Journal of Pharmacology and Experimental Therapeutics 1998; 284(-3-):1227-1233. >>> Aldosterone;; Propylene glycol;; SC;; rat;; 2002;; 13-15 days;; replacement therapy (adrenalectomy);.

P4322 Vaher,P.R., McEwen,B.S. Effects of aldosterine (sic) replacement on the radial arm maze performance of adrenalectomized rats. Neuroendocrinology Letters 1998; 19(-3-):125-137. >>> Aldosterone;; Propylene glycol;; SC;; rat;; 7 days;; controls received sham adrenalectomy and/or "dummy pump", a nylon screw spacer of ~ same size and shape as mp; replacement therapy (adrenalectomy);.

P6330 MacLeod,A.B., Vasdev,S., Smeda,J.S. The Role of Blood Pressure and Aldosterone in the Production of Hemorrhagic Stroke in Captopril-Treated Hypertensive Rats. Stroke 1997; 28(-9-):1821-1829. >>> Aldosterone; PEG 300; SC; Rat; 2002; 4-7 weeks; Controls received mp w/ vehicle; functionality of mp verified by drug plasma levels; no stress (see pg. 1826); cardiovascular; ischemia (cerebral).

P6312 Takeda,Y., Miyamori,I., Yoneda,T., Furukawa,K., Inaba,S., Takeda,R., Mabuchi,H. Brain Nitric Oxide Synthase Messenger RNA in Central Mineralocorticoid Hypertension. Hypertension 1997; 30(-4-):953-956. >>> Aldosterone; aldosterone, 19-nor; CSF, artificial; ethanol; SC; CSF/CNS; Rat; 2002; 4 weeks; Controls received mp w/ vehicle; comparison of sc mp vs. icv mp; no stress (see pg. 954); cardiovascular; "there were no signs of illness, infection, or behavorial deficits in any of the rats in the fire study groups." (p.954).

P4613 Fanestil,D.D., Vaughn,D.A., Blakely,P  Am.J.Physiol.(Regulatory Integrative Comp.Physiol.42) 1997; 273(--):R1241-R1245. >>> Aldosterone;; SC;; rat;; 6 days;; controls received mp w/vehicle;.

P3834 Grubb,B.R., Boucher,R.C. Enhanced colonic Na+ absorption in cystic fibrosis mice versus normal mice. Am.J.Physiol. 1997; 272(-35-):G393-G400. >>> Aldosterone; PEG; SC; mice; 2001; 7 days; no comment posted.

P4168 Velazquez,H., Bartiss,A., Bernstein,P., Ellison,D.H. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am.J.Physiol.(Renal Fluid Electrolyte Physiol.39) 1996; 270(--):F211-F219. >>> Aldosterone; Dexamethasone; Ethanol; Saline; IP; rat; 2ML1; 3-5 days; replacement therapy (adrenalectomy); steroids infused singly or concomitantly.

P4145 Tordoff,M.G. Adrenalectomy decreases NaCl intake of rats fed low-calcium diets. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.39) 1996; 270(--):R11-R21. >>> Aldosterone; Propylene glycol; rat; 2002; 14 days; functionality of mp verified by aldosterone plasma levels; replacement therapy (adrenalectomy).

P3497 Riftina,F., Angulo,J., Pompei,P., McEwen,B. Regulation of angiotensinogen gene expression in the rat forebrain by adrenal steroids and relation to salt appetite. Mol.Brain Research 1995; 33(--):201-208. >>> RU-28362; Aldosterone; SC; rat; 2001; 7 days; controls received mock pumps; replacement therapy (adrenalectomy).

P3495 Pompei,P., Riftina,F., McEwen,B.S. Effect of adrenal steroids on preproneurokinin-A gene expression in discrete regions of the rat brain. Mol.Brain Research 1995; 33(--):209-216. >>> Aldosterone; RU-28362; Propylene glycol; rat; 8 days; replacement therapy (adrenalectomy).

P3054 Young,M  Steroids 1995; 60(--):133-136. >>> Aldosterone; SC; rat; 8 weeks; long-term study, pumps replaced at 4 weeks.

P4047 Sun,Y., Weber,K.T. Fibrosis and myocardial ACE: possible substrate and independence from circulating angiotensin II. J.Cardiac Failure 1994; 1(-1-):81-89. >>> Angiotensin II; Aldosterone; SC; rat; 2, 4, 6 weeks; peptides; cardiovascular.

P3168 Miller,A.H., Spencer,R.L., Hassett,J., Kim,C., Rhee,R., Ciurea,D., Dhabhar,F., McEwen,B., Stein,M. Effects of selective type I and II adrenal steroid agonists on immune cell distribution. Endocrinology 1994; 135(-5-):1934-1944. >>> Aldosterone; RU-28362; Corticosterone; Propylene glycol; SC; rat; 7 days; replacement therapy (adrenalectomy).

P2905 Palmer,L.G., Antonian,L., Frindt,G. Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K. J.Gen.Physiol. 1994; 104(--):693-710. >>> Aldosterone; Corticosterone; PEG 300; SC; rat; 2002; no duration posted; replacement therapy (adrenalectomy).

P2881 Robert,V., Thiem,N.V., Cheav,S.L., Mouas,C., Swynghedauw,B., Delcayre,C. Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension. Hypertension 1994; 24(--):30-36. >>> Aldosterone, d-; SC; rat; 8 weeks; controls received mp with serum; long-term study, pumps replaced every 15 days.

P2777 Wang,W  Hypertension 1994; 24(--):571-575. >>> Aldosterone; Saline; SC; dog; 2ML2; 10 days; controls received mp w/ saline.

P3175 Miller,A.H., Spencer,R.L., Husain,A., Rhee,R., McEwen,B.S., Stein,M. Differential expression of type I adrenal steroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone. Endocrinology 1993; 133(-5-):2133-2139. >>> Aldosterone; RU-28362; Propylene glycol; SC; rat; no duration posted; controls received sham pumps; replacement therapy (adrenalectomy).

P2975 Sun,Y., Ratajska,A., Zhou,G., Weber,K.T. Angiotensin-converting enzyme and myocardial fibrosis in the rat receiving angiotensin II or aldosterone. J.Lab.Clin.Med. 1993; 122(-4-):395-403. >>> Aldosterone; Angiotensin II; rat; 2,4,6 weeks; controls received no operation or treatment; replacement therapy (nephrectomy); long-term study; peptides.

P2951 Sun,Y., Weber,K.T. Angiotensin II and aldosterone receptor binding in rat heart and kidney: response to chronic angiotensin II or aldosterone administration. J.Lab.Clin.Med. 1993; 122(-4-):404-411. >>> Angiotensin II; Aldosterone; rat; 2,4,6,8 weeks; controls received no treatment or surgery; replacement therapy (nephrectomy); long-term study; peptides.

P2904 Palmer,L.G., Antonian,L., Frindt,G. Regulation of the Na-K pump of the rat cortical collecting tubule by aldosterone. J.Gen.Physiol. 1993; 102(--):43-57. >>> Aldosterone; Amiloride; PEG 300; SC; rat; 2002; no duration posted; agents given concomitantly.

P2681 Campbell,S.E., Janicki,J.S., Matsubara,B.B., Weber,K.T. Myocardial fibrosis in the rat with mineralocorticoid excess; prevention of scarring by amiloride. Am.J.Hypertens. 1993; 6(-6-):487-495. >>> Aldosterone; Amiloride; PEG; Water, double-distilled; Ethanol; SC; rat; 2002; 8 weeks; controls received mp w/ vehicle; long-term study, pumps replaced every 2 weeks; agents given separately and together.

P2662 Brilla,C.G., Matsubara,L.S., Weber,K.T. Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism. J.Mol.Cell.Cardiology 1993; 25(--):563-575. >>> Aldosterone; SC; rat; 2002; 8 weeks; controls were unoperated, untreated rats; functionality of mp verified by plasma levels; long-term study.

P2442 Tordoff,M.G., Hughes,R.L., Pilchak,D.M. Different effects of three aldosterone treatments on plasma aldosterone and salt intake. Physiol.Behav. 1993; 54(--):129-134. >>> Aldosterone; Propylene glycol; SC; rat; 2ML2; 14 days; controls received no treatment or anesthesia only; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy); comparison of daily injections vs. controlled-release pellets; "The most consistent and stable elevation of plasma aldosterone was obtained using Alzet minipumps..." (p. 132); Aldo half-life (15-20 ml/min); animal info (sprague-dawley 125-150 grams); "It has been well established that the minipumps produce a constant, dose-related elevation of plasma aldosterone levels." (p. 129); "Rats given aldosterone by controlled-release pellet showed large changes in plasma aldosterone concentrations during treatment." (p. 131); "Rats in the [ALZET pump group] had stable plasma aldosterone concentrations across the 14-day test period." (p. 131);.

P2250 Eiam-Ong,S., Kurtzman,N.A., Sabatini,S. Effect of furosemide-induced hypokalemic metabolic alkalosis on renal transport enzymes. Kidney Int. 1993; 43(--):1015-1020. >>> Aldosterone; Dexamethasone; Furosemide; PEG 400; Saline; SC; rat; 2002; 7 days; replacement therapy (adrenalectomy); multiple pumps per animal (2); antihypertensive.

P2271 Fragman,S., Harnik,M., Peleg,E., Zamir,N., Rosenthal,T. The hypertensinogenic activity of 18,19-dihydroxycorticosterone in adrenalectomized rats. Am.J.Hypertens. 1992; 5(--):399-401. >>> Aldosterone; Corticosterone, dihydroxy-; Propylene glycol; SC; rat; 2002; 2 weeks; controls received mp w/vehicle; replacement therapy (adrenalectomy).

P2224 Brilla,C.G., Weber,K.T. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat. Cardiovasc.Res. 1992; 26(--):671-677. >>> Aldosterone; SC; rat; 2002; 8 weeks; no comment posted.

P2216 ten Cate,W.J.F., Rarey,K.E. Plasma membrane modulation of ampullar dark cells by corticosteroids. Arch Otolaryngol.Head Neck Surg. 1991; 117(--):96-99. >>> Aldosterone; Dexamethasone; Propylene glycol; SC; rat; 2002; 14 days; controls received mp w/vehicle; animals were adrenalectomized.

P1952 Semafuko,W.E.B., Morris,D.J. Effect of high calcium diet on the development of high blood pressure in intact spontaneously hypertensive rats and in adrenalectomized spontaneously hypertensive rats treated with aldosterone. Steroids 1991; 56(--):131-135. >>> Aldosterone; Propylene glycol; SC; rat; 2002; 2 weeks; replacement therapy (adrenalectomy).

P3242 Brilla,C.G., Pick,R., Tan,L.B., Janicki,J.S., Weber,K.T. Remodeling of the rat right and left ventricles in experimental hypertension. Circ.Res. 1990; 67(--):1355-1364. >>> Aldosterone; rat; 8 weeks; controls received no operation or mp without ALDO; replacement therapy (nephrectomy); long-term study, pumps replaced every 20 days.

P1668 Doucet,A., Barlet-Bas,C., Siaume-Perez,S., Khadouri,C., Marsy,S. Gluco- and mineralocorticoids control adenylate cyclase in specific nephron segments. Am.J.Physiol. 1990; 258(--):F812-F820. >>> Aldosterone; Dexamethasone; SC; rat; no duration posted; no comment posted.

P1649 Gomez-Sanchez,E.P., Venkataraman,M.T., Thwaites,D., Fort,C. ICV infusion of corticosterone antagonizes ICV-aldosterone hypertension. Am.J.Physiol. 1990; 258(-21-):E649-E653. >>> Aldosterone; RU-26988; Corticosterone; CSF, artificial; Propylene glycol; CSF/CNS; rat; 2002; 28 days; dose-response (graph); pump replaced at 2 weeks; propylene glycol at 2%.

P1637 Gomez-Sanchez,E.P., Fort,C.M., Gomez-Sanchez,C.E. Intracerebroventricular infusion of RU28318 blocks aldosterone-salt hypertension. Am.J.Physiol. 1990; 258(-21-):E482-E484. >>> Aldosterone; RU-28318; Propylene glycol; CSF/CNS; SC; rat; 2002; 24 days; dose-response (graph); pump replaced at 2 weeks; comparison of central vs. peripheral administration, pellets.

P1630 Hui,R., Grose,J.H., Lebel,M., Falardeau,P. Prostanoids and aldosterone-induced mild experimental hypertension in rats. Hypertension 1990; 15(-2-):198-203. >>> Aldosterone; PEG; SC; rat; 2002; 4 weeks; pump replaced at 2 weeks; no stress (see pg. 199).

P1596 Smith,J.M., Jones,A.W. Calcium antagonists inhibit elevated potassium efflux from aorta of aldosterone-salt hypertensive rats. Hypertension 1990; 15(-1-):78-83. >>> Aldosterone; PEG; SC; rat; 2-4 weeks; composition of normal physiological saline (p. 79).

P1559 Yagil,Y., Levin,M., Krakoff,L.R. Effect of glucocorticoid deficiency on arterial pressure in conscious spontaneously hypertensive rats. Am.J.Hypertens. 1989; 2(--):99-104. >>> Aldosterone; Dexamethasone; PEG 400; Saline; IP; rat; 2001; 6 days; functionality of mp verified by serum levels, urinary excretion; replacement therapy (adrenalectomy).

P1477 Dallman,M.F, Levin,N., Cascio,C.S., Akana,S.F., Jacobson,L., Kuhn,R.W. Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors. Endocrinology 1989; 124(-6-):2844-2850. >>> Aldosterone; Dexamethasone; Propylene glycol; Saline; rat; 2001; 5 days; dose-response; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P1077 Smith,J.M., Cragoe,E.J., Jones,A.W. Nisoldipine inhibition of sodium influx into aorta from aldosterone-salt-hypertensive rats. Hypertension 1989; 13(--):676-680. >>> Aldosterone, d-; PEG; SC; rat; 3-4 weeks; pump model not stated; pump replaced after 2 weeks.

P1535 Stanton,B.A., Kaissling,B. Adaptation of distal tubule and collecting duct to increased Na delivery; II Na+ and K+ transport. Am.J.Physiol. 1988; 255(--):F1269-F1275. >>> Aldosterone; Dexamethasone; Furosemide; Saline; SC; rat; 2002; 2ML1; 6 days; Multiple pumps per animal (2); replacement therapy (adrenalectomy); antihypertensive.

P1534 Kaissling,B., Stanton,B.A. Adaptation of distal tubule and collecting duct to increased sodium delivery I; ultrastructure. Am.J.Physiol. 1988; 255(--):F1256-F1268. >>> Aldosterone; Dexamethasone; Furosemide; Vasopressin, arginine; Saline; SC; Rat; 2002; 2ML1; 6 days; Dose-response; multiple pumps per animal (2); functionality of mp verified by plasma levels; replacement therapy (adrenalectomy); antihypertensive.

P1429 Rosenthal,T., Shani,M., Peleg,E., Harnik,M. The hypertensinogenic activity of 18-hydroxy-19-norcorticosterone in the adrenalectomized rat. Am.J.Hypertens. 1988; 1(-3-):49S-51S. >>> Aldosterone, 18-; Hydroxy-19-norcorticosterone; Hydroxycortisone, 18-; Propylene glycol; SC; rat; 2002; 2 weeks; hc and aldo administered concomitantly.

P1378 Harrap,S.B., Clark,S.A., Fraser,R., Towrie,A., Brown,A.J., Lever,A.F. Effects of sodium intake and aldosterone on the renal pressure-natriuresis. Am.J.Physiol. 1988; 254(--):F697-F703. >>> Aldosterone; SC; rat; 1 week; pump models not stated; dose-response (table, text); functionality of mp verified by serum levels.

P1371 Garg,L.C., Narang,N. Effects of aldosterone on NEM-sensitive ATPase in rabbit nephron segments. Kidney Int. 1988; 34(--):13-17. >>> Aldosterone; IP; rabbit; 7 days; dose-response; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P1367 Janiak,P., Brody,M.J. Central interactions between aldosterone and vasopressin on cardiovascular system. Am.J.Physiol. 1988; 255(--):R166-R173. >>> Aldosterone; RU-28318; Ethanol; Saline; CSF/CNS; rat; 2001; 2, 4 days; bilateral cannulas for concomitant drug infusion.

P1327 Rabinowitz,L., Castonguay,T.W., Rutledge,J.C. Aldosterone reverses potassium-induced food aversions in adrenalectomized rats. Physiol.Behav. 1988; 42(--):137-140. >>> Aldosterone, d-; Dexamethasone; SC; rat; 2002; 14 days; sham operated controls; replacement therapy (adrenalectomy).

P1188 Halevy,J., Boulpaep,E.L., Budinger,M.E., Binder,H.J., Hayslett,J.P. Glucocorticoids have a different action than aldosterone on target tissue. Am.J.Physiol. 1988; 254(--):F153-F158. >>> Aldosterone; RU-28362; Dexamethasone; Ethanol; rat; 2001; no duration posted; controls received mp w/ vehicle.

P1186 Yagil,Y., Krakoff,L.R. The differential effect of aldosterone and dexamethasone on pressor responses in adrenalectomized rats. Hypertension 1988; 11(-2-):174-178. >>> Aldosterone; Dexamethasone; PEG; Saline; IP; rat; 1701; 2001; no duration posted; controls received mp w/ vehicle; dose-response (table); polyethylene glycol was used as vehicle for aldosterone; functionality of mp verified; replacement therapy (adrenalectomy).

P1341 Edmonds,C.J., Willis,C.L. Aldosterone in colonic potassium adaptation in rats. J.Endocrinol. 1987; 117(--):379-386. >>> Aldosterone; Dexamethasone; IP; rat; 3 days; dose-response (text); replacement therapy (adrenalectomy).

P1332 Rutledge,J., Rabinowitz,L. Kaliuretic regulatory factors in the rat. Am.J.Physiol. 1987; 253(--):F1182-F1196. >>> Aldosterone; Dexamethasone; SC; rat; 2002; 14 days; controls; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P1280 Rabinowitz,L., Berlin,R., Yamauchi,H. Plasma potassium and diurnal cyclic potassium excretion in the rat. Am.J.Physiol. 1987; 253(--):F1178-F1181. >>> Aldosterone; Dexamethasone; Saline; rat; 2002; 8, 18 days; replacement therapy (adrenalectomy).

P1107 Grubb,B.R., Bentley,P.J. Aldosterone-induced, amiloride-inhibitable short-circuit current in the avian ileum. Am.J.Physiol. 1987; 253(--):G211-G216. >>> Aldosterone; SC; bird (chicken); 2ML4; 2 weeks; dose-response (text); comparison of single injection vs. mp infusion; vehicle for Aldosterone not specified.

P1104 Scandling,J.D., Ornt,D.B. Mechanism of potassium depletion during chronic metabolic acidosis in the rat. Am.J.Physiol. 1987; 252(--):F122-F130. >>> Aldosterone, d-; Dexamethasone; DMSO; IP; rat; 2001; 7 days; dose-response; agents infused separately; 2 mp per animal until day 4 when a 2nd aldosterone mp was implanted; replacement therapy (adrenalectomy).

P1088 Kashgarian,M., Ardito,T., Hirsch,D.L., Hayslett,J.P. Response of collecting tubule cells to aldosterone and potassium loading. Am.J.Physiol. 1987; 253(--):F8-F14. >>> Aldosterone; Ethanol; Saline; SC; rat; 5-7 days; different doses of agents infused; mp model not stated; replacement therapy (adrenalectomy).

P1068 Smith,J.M., Jones,S.B., Bylund,D.B., Jones,A.W. Characterization of the alpha-1 adrenergic receptors in the thoracic aorta of control and aldosterone hypertensive rats: Correlation of radioligand binding with potassium efflux and contraction. J.Pharmacol.Exp.Ther. 1987; 241(-3-):882-890. >>> Aldosterone, d-; PEG; SC; rat; 2 weeks; controls received mp w/vehicle; mp model not stated.

P1054 Douglas,J.G. Estrogen effects on angiotensin receptors are modulated by pituitary in female rats. Am.J.Physiol. 1987; 252(--):E57-E62. >>> Aldosterone; Estradiol; PEG; IP; rat; 2001; 1-7 days; controls received mp w/aldosterone; agents infused together and/or seperately; replacement therapy (oophorectomy).

P1018 Mujais,S.K. Effects of aldosterone on rat collecting tubule N-ethylmaleimide-sensitive adenosine triphosphatase. J.Lab.Clin.Med. 1987; 109(--):34-39. >>> Aldosterone; SC; rat; 2001; 7 days; controls received sham surgical procedure.

P1014 Basile,A.S., Ostrowski,N.L., Skolnick,P. Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy. J.Pharmacol.Exp.Ther. 1987; 240(-3-):1006-1013. >>> Aldosterone acetate; Dexamethasone acetate; DMSO; Ethanol; Saline; SC; rat; 7 days; controls received mp w/vehicle; agents infused sep. with appropriate vehicle; sham-op animals implanted with mp containing vehicle only; replacement therapy (adrenalectomy).

P0999 Douglas,J.G. Corticosteroids decrease glomerular angiotensin receptors. Am.J.Physiol. 1987; 252(--):F453-F457. >>> Aldosterone; Dexamethasone sodium phosphate; Spironolactone; Ethanol; PEG; rat; 1701; 36 hours; controls received mp w/vehicle; agents infused separately with appropriate vehicles.

P1191 Yagil,Y., Koreen,R., Krakoff,L.R. Role of mineralocorticoids and glucocorticoids in blood pressure regulation in normotensive rats. Am.J.Physiol. 1986; 251(--):H1354-H1360. >>> Aldosterone; Dexamethasone; PEG; Saline; IP; rat; 1701; 2001; no duration posted; controls received sham op or mp w/ vehicle; high salt diet; replacement therapy (adrenalectomy).

P0881 Mujais,S.K., Chekal,M.A., Hayslett,J.P., Katz,A.I. Regulation of renal Na+-K+-ATPase in the rat: role of increased potassium transport. Am.Physiol.Soc. 1986; (--):199-207. >>> Aldosterone; SC; rat; 2001; 7 days; replacement therapy (bilaterial adrenalectomy).

P0850 McEwen,B.S., Lambdin,L.T., Rainbow,T.C., De Nicola,A.F. Aldosterone effects on salt appetite in adrenalectomized rats. Neuroendocrinology 1986; 43(--):38-43. >>> Aldosterone, d-; RU-28313; Corticosterone; Propylene glycol; SC; rat; 2001; 2-3 days; controls received mp w/vehicle; hypertension; 3 doses of aldosterone infused; replacement therapy (adrenalectomy); RU-28313 is an antimineralcorticoid.

P0845 Rabinowitz,L., Wydner,C.J., Smith,K.M., Yamauchi,H. Diurnal potassium excretory cycles in the rat. Am.J.Physiol. 1986; 250(--):F930-F941. >>> Aldosterone, d-; Dexamethasone; Ethanol; PEG; Saline; SC; rat; 2002; 3 days; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents.

P0798 Magliola,L., McMahon,E.G., Jones,A.W. Alterations in active Na-K transport during mineralocorticoid-salt hypertension in the rat. Am.J.Physiol. 1986; 250(--):C540-C546. >>> Aldosterone, d-; PEG; SC; rat; 3-4 weeks; mp model not stated; mp replaced biweekly.

P0796 Gorsline,J., Harnik,M., Tresco,P.A., Morris,D.J. Hypertensinogenic activities of ring a-reduced metabolites of aldosterone. Hypertension 1986; 8(-I-):I187-I190. >>> Aldosterone; Aldosterone, 3a,5a-tetrahydro-; Aldosterone, 3a,5b-tetrahydro-; Aldosterone, 3b,5a-tetrahydro-; Aldosterone, 5a-dihydro-; Propylene glycol; SC; rat; 2002; 2-3 weeks; controls received mp w/ vehicle; replacement therapy (adrenalectomy); mp replaced after 2 weeks for some experiments; dose-response (blood pressure); hypertension.

P0780 Devenport,L.D., Hale,R.L. Neonatal aldosterone administration alters later response to adrenalectomy and aldosterone infusion in the rat. Physiol.Behav. 1986; 36(-3-):579-581. >>> Aldosterone; PEG; SC; rat; 2002; 12 days; replacement therapy (bilateral adrenalectomy); controls received sham pump; see ref. 2 (P731).

P0757 Gomez-Sanchez,E.P. Intracerebroventricular infusion of aldosterone induces hypertension in rats. Endocrinology 1986; 118(--):819-823. >>> Aldosterone; Prorenone; Cerebrospinal fluid, artificial; Ethanol; HCl; CSF/CNS; rat; 2002; 30 days; pump replaced on day 14; no stress (p.820); mp connected to steel cannula in ventricle via polyethylene catheter; mp sc in flank; separate and simultaneous infusion of agents.

P0755 Martin,A.F., Paul,R.J., McMahon,E.G. Isomysin transitions in ventricles of aldosterone-salt hypertensive rats. Hypertension 1986; 8(-2-):128-132. >>> Aldosterone, d-; PEG; SC; rat; 2ML4; 4 weeks; mp infusion in conjunction w/ salt supplements; controls received mp w/ vehicle.

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