References on the Administration of Corticosterone Using ALZET^® Osmotic Pumps

P7872 Maxwell,C.R., Ehrlichman,R.S., Liang,Y.L., Gettes,D.R., Evans,D.L., Kanes,S.J., Abel,T., Karp,J., Siegel,S.J. Corticosterone modulates auditory gating in mouse. Neuropsychopharmacology 2006; 31(-5-):897-903. >>> Corticosterone; PEG 400; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; dose-response (fig. 3); comparison of SC pellets vs. mp; animal info (male, C57BL/6J, 10-11 wk. old).

P7810 Liu,H.H., Payne,H.R., Wang,B., Brady,S.T. Gender differences in response of hippocampus to chronic glucocorticoid stress: Role of glutamate receptors. Journal of Neuroscience Research 2006; 83(-5-):775-786. >>> Corticosterone; PEG; SC; Mice; 2002; 2 weeks; Controls received no treatment; functionality of mp verified by plasma corticosterone levels; animal info (male, female, C57BL/6J, 7 wk old); "Although daily injections do elevate plasma corticosterone chronically, animals experience spikes of corticosterone associated with both handling and injection" (pg. 776).

P7432 Ellis,S., Mouihate,A., Pittman,Q.J. Early life immune challenge alters innate immune responses to lipopolysaccharide: implications for host defense as adults. FASEB Journal 2005; 19(-8-):U826-U842. >>> Corticosterone; PEG; IP; Rat; 2001; 1 week; Replacement therapy (adrenalectomy); no stress (see pg. 4); immunology; post op. care (derapen); "the survival rate of this procedure (ADX + mp) was 100% with animals having normal body temperature within 24 hours after the surgery.".

P7247 Nuber,U.A., Kriaucionis,S., Roloff,T.C., Guy,J., Selfridge,J., Steinhoff,C., Schulz,R., Lipkowitz,B., Ropers,H.H., Holmes,M.C., Bird,A. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Human Molecular Genetics 2005; 14(-15-):2247-2256. >>> Corticosterone; DMSO; polypropylene glycol; SC; Mice; 48 hours; Controls received mp w/ vehicle; functionality of mp verified by plasma corticosterone levels; comparison of silastic implants vs. mp; 50% DMSO.

P6237 Watanobe,H., Habu,S. Adrenal glucocorticoids do not mediate impaired reproductive function induced by lipopolysaccharide in rats. Neuroendocrinology 2003; 78(-1-):23-28. >>> Corticosterone; PEG 400; SC; Rat; 2ML2; 14 days; Controls received no mp and saline injection; functionality of mp verified by plasma drug concentrations; replacement therapy (orchidectomy; adrenalectomy); LPS given by injection.

P5331 Man,M.S., Young,A.H., McAllister-Williams,R.H. Corticosterone modulation of somatodendritic 5-HT1A receptor function in mice. JOURNAL OF PSYCHOPHARMACOLOGY 2002; 16(-3-):245-252. >>> Corticosterone; PEG; SC; Mice; 2001; 72 hours; Corticosterone plasma levels checked; replacement therapy (adrenalectomy); comparison of SC injections vs mp.

P5226 Wang,J., Charboneau,R., Balasubramanian,S., Barke,R.A., Loh,H.H., Roy,S. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. J Leukoc.Biol 2002/5; 71(-5-):782-790. >>> Corticosterone; PEG 400; SC; Mice; 48 hours; Controls received mp w/ vehicle; functionality of mp verified by corticosterone plasma levels; dose-response (p. 784); immunology;.

P4979 Yau,J.L.W., Noble,J., Kenyon,C.J., Hibberd,C., Kotelevtsev,Y., Mullins,J.J., Seckl,J.R. Lack of tissue glucocorticoid reactivation in 11 beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2001; 98(--):4716-4721. >>> Corticosterone; Saline; Ethanol; Radio-isotopes; SC; mice; 2001; 7 days; brain tissue distribution; Vehicle was 90% saline; 10% ethanol; aging; corticosterone brain distribution.

P4494 Sacedón,R, Vicente,A, Varas,A, Jiménez,E, Munoz,J.J, Zapata,A.G  Blood 1999/10/15; 94(-8-):2819-2826. >>> Corticosterone; Propylene glycol; NaCl; SC; Rat (pregnant); 2ML4; ; Controls received sham surgery; functionality of mp verified by corticosterone levels in plasma; replacement therapy (adrenalectomy); teratology;.

P3714 Sainio,E.-L. The role of adrenal hormones in the activation of tryptophan 2,3-dioxygenase by nicotinic acid in rat liver. Meth.Find Exp.Clin.Pharmacol. 1997; 19(-7-):465-470. >>> Epinephrine; Corticosterone; Ethanol; NaCl; SC; rat; 2ML1; 6 days; controls received mp w/vehicle; replacement therapy (adrenalectomy).

P4144 Souness,G.W., Morris,D.J. 11a- and 11b- hydroxyprogesterone, potent inhibitors of 11b-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension 1996; 27(-pt 1-):421-425. >>> Progesterone, 11a; Hydroxyprogesterone, 11b; RU-28318; Corticosterone; Propylene glycol; SC; rat; 2002; 14 days; controls received mp w/vehicle; functionality of mp verified by residual volume; replacement therapy (adrenalectomy); agents infused singly and concomitantly in same pump; cardiovascular.

P3153 DeKrey,G.K., Kerkvliet,N.I. Effects of exogenous corticosterone treatment on alloantigen-specific cytotoxic T lymphocyte activity in mice. J.Pharmacol.Exp.Ther. 1995; 273(-2-):823-829. >>> Corticosterone; Dexamethasone; PEG 400; mice; 2002; 14 days; controls received mp with PEG; functionality of mp verified by plasma levels; immunology; agent infusion delayed 1 day after surgery (by using catheter tubing).

P3168 Miller,A.H., Spencer,R.L., Hassett,J., Kim,C., Rhee,R., Ciurea,D., Dhabhar,F., McEwen,B., Stein,M. Effects of selective type I and II adrenal steroid agonists on immune cell distribution. Endocrinology 1994; 135(-5-):1934-1944. >>> Aldosterone; RU-28362; Corticosterone; Propylene glycol; SC; rat; 7 days; replacement therapy (adrenalectomy).

P2905 Palmer,L.G., Antonian,L., Frindt,G. Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K. J.Gen.Physiol. 1994; 104(--):693-710. >>> Aldosterone; Corticosterone; PEG 300; SC; rat; 2002; no duration posted; replacement therapy (adrenalectomy).

P3238 Lobo,M.J., Remesar,X., Alemany,M. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Biochem.Molec.Biol.Intl. 1993; 29(-2-):349-358. >>> Progesterone; Cortisol; Cortisone; Corticosterone; Dehydroepiandrosterone; Androstenedione, 4-; Androstendiol, 5-; Testosterone; Nortestosterone, 19-; Estradiol, B-; Estrone; Estriol; Deoxycorticosterone; PEG 400; IV (lower cava); rat; 2002; 15 days; controls received mp with PEG; no stress (see pg. 351); pumps placed into peritoneal cavity and sutured to musculature; surgical wound sprinkled with sulphathiazol.

P2441 Thordarson,G., Fielder,P., Lee,C., Hom,Y.K., Robleto,D., Ogren,L., Talamantes,F. Mammary gland differentiation in hypophysectomized, pregnant mice treated with corticosterone and thyroxine. Biol.Reprod. 1992; 47(--):676-682. >>> Corticosterone; Cyclodextrin; SC; mice (pregnant); 2001; no duration posted; controls received mp w/ vehicle, sham operation or no treatment; vehicle was Molecusol.

P2271 Fragman,S., Harnik,M., Peleg,E., Zamir,N., Rosenthal,T. The hypertensinogenic activity of 18,19-dihydroxycorticosterone in adrenalectomized rats. Am.J.Hypertens. 1992; 5(--):399-401. >>> Aldosterone; Corticosterone, dihydroxy-; Propylene glycol; SC; rat; 2002; 2 weeks; controls received mp w/vehicle; replacement therapy (adrenalectomy).

P2032 Petitte,J.N., Etches,R.J. Daily infusion of corticosterone and reproductive function in the domestic hen (Gallus domesticus). Gen.Comp.Endocrinol. 1991; 83(-3-):397-405. >>> Corticosterone; PEG 400; SC; bird (chicken); 2ML2; 2ML4; 14 days; dose-response; pulsed delivery achieved by externalizing PE-60 catheter from pump. Catheter could be disconnected at will for intermittent delivery: 10 hr on/14 hr off, 4 hr on/20 hr off, 24 hr on/0 hr off (pg 398-399).

P1649 Gomez-Sanchez,E.P., Venkataraman,M.T., Thwaites,D., Fort,C. ICV infusion of corticosterone antagonizes ICV-aldosterone hypertension. Am.J.Physiol. 1990; 258(-21-):E649-E653. >>> Aldosterone; RU-26988; Corticosterone; CSF, artificial; Propylene glycol; CSF/CNS; rat; 2002; 28 days; dose-response (graph); pump replaced at 2 weeks; propylene glycol at 2%.

P1849 Brown,G., Douglas,J. Effect of angiotensin II infusion in rats on Na, K-ATPase activity in renal cortical microsomal preparations. Arch.Biochem.Biophys. 1989; 275(-1-):236-243. >>> Angiotensin II; Corticosterone; Acetic acid; PEG 400; IP; rat; 24, 72 hours; replacement therapy (adrenalectomy); peptides; multiple pumps per animal (2) placed IP.

P1265 Jones,R.B., Beuving,G., Blokhuis,H.J. Tonic immobility and Heterophil/lymphocyte responses of the domestic fowl to corticosterone infusion. Physiol.Behav. 1988; 42(-3-):249-253. >>> Corticosterone; PEG 400; SC; bird (chicken); 2ML2; 11 days; controls received mp w/vehicle; dose-response; functionality of mp verified by previous studies.

P1139 John,T.M., Viswanathan,M., Etches,R.J., Pilo,B., George,J.C. Influence of corticosterone infusion on plasma levels of catecholamines, thyroid hormones, and certain metabolites in laying hens. Poult.Sci. 1987; 66(-6-):1059-1063. >>> Corticosterone; PEG 400; SC; bird (chicken); 14/28 days; Pump model not stated; controls received mp w/ vehicle.

P1003 Mann,D.R., Free,C., Nelson,C., Scott,C., Collins,D.C. Mutually independent effects of adrenocorticotropin on luteinizing hormone and testosterone secretion. Endocrinology 1987; 120(--):1542-1550. >>> ACTH(1-24); Corticosterone; Propylene glycol; Saline; SC; rat; 2001; 2ML1; 72/96 hours; controls received mp w/vehicle; peptides; replacement therapy (adrenalectomy).

P1202 Powell,P.C., Davison,T.F. Induction of Marek's disease in vaccinated chickens by treatment with betamethasone or corticosterone. Isr.J.Vet.Med. 1986; 42(-2-):73-78. >>> Corticosterone; SC; bird (chicken); 14 days; Pump model not stated; controls received saline injections; concomitant cyclophosphamide injections; immunology.

P0850 McEwen,B.S., Lambdin,L.T., Rainbow,T.C., De Nicola,A.F. Aldosterone effects on salt appetite in adrenalectomized rats. Neuroendocrinology 1986; 43(--):38-43. >>> Aldosterone, d-; RU-28313; Corticosterone; Propylene glycol; SC; rat; 2001; 2-3 days; controls received mp w/vehicle; hypertension; 3 doses of aldosterone infused; replacement therapy (adrenalectomy); RU-28313 is an antimineralcorticoid.

P0731 Devenport,L.D., Goodwin,K.G., Hopkins,P.M. Continuous infusion of aldosterone: correlates of body weight gain. Pharmacol.Biochem.Behav. 1985; 22(--):707-709. >>> Corticosterone; PEG; SC; rat; 2002; no duration posted; replacement therapy (adrenalectomy); controls received sham pumps; varied doses of aldosterone administered in combination w/ mp infusion; mp delivery failure? (see pg. 707).

P0710 Mills,D.E., Woods,R.B. Interaction of prolactin with adrenal hormones in blood pressure regulation in rats. Am.J.Physiol. 1985; 249(--):E614-E618. >>> Corticosterone; Epinephrine; Norepinephrine; Prolactin, ovine; Ethanol; Sodium chloride; Water; IP; rat; 2001; 7 days; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents; multiple pumps per animal (2) for CORT; hypertension; controls received mp w/NaCl; peptides.

P0709 Fukushima,M., Lupien,J., Bray,G.A. Interaction of light and corticosterone on food intake and brown adipose tissue of the rat. Am.J.Physiol. 1985; 249(--):R753-R757. >>> Corticosterone; Propylene glycol; Saline; rat; 2ML2; 2 weeks; comparison of ip injection vs. mp infusion; replacement therapy (adrenalectomy); mp functionality (rates) verified in vitro prior to study.

P0656 van Zon,A.A.J.C., Eling,W.M.C., Schetters,T.P.M., Hermsen,C.C. ACTH-dependent modulation of malaria immunity in mice. Parasite Immunol. 1985; 7(-2-):107-117. >>> Cosyntropin; Corticosterone; Dexamethasone; Hank's solution; HEPES solution; PEG; SC; mice; 2002; no duration posted; comparison of agents effects; replacement therapy (adrenalectomy); tetracosactrin (cosyntropin) is a synthetic ACTH analog; dose-response data; immunology.

P0612 Phillips,R., Crock,C., Funder,J. Effect of mineralocorticoids and glucocorticoids on compensatory adrenal growth in rats. Am.J.Physiol. 1985; 248(-4-):E450-E456. >>> Aldosterone; Fluorocortisol acetate, 9a-; Corticosterone; Deoxycorticosterone; Dexamethasone; Ethanol; Propylene glycol; Water; SC; rat; 3 days; replacement therapy (unilateral adrenalectomy); each mp used twice, 3 days in one animal, then 3 days in another; cannot tell if stability/concentration of ald. determined by RIA before or after exp.

P0566 Will,P.C., Cortright,R.N., DeLisle,R.C., Douglas,J.G., Hopfer,U. Regulation of amiloride-sensitive electrogenic sodium transport in the rat colon by steroid hormones. Am.J.Physiol. 1985; 248(-1-):G124-G132. >>> Aldosterone; Corticosterone; Dexamethasone phosphate; Estradiol, 17B-; Progesterone; Testosterone; PEG 400; PEG 600; IP; rat; 1701; 2001; 3-8 days; comparison of agents effects; replacement therapy (adrenalectomy&ovariectomy); controls received mp with solvent or glass rods of mp size; no stress implied G125, weight regained; functionality of mp verified.

P0061 Will,P.C., Cortright,R.N., Hopfer,U. Polyethylene glycols as solvents in implantable osmotic pumps. J.Pharm.Sci. 1980; 69(-6-):747-749. >>> Aldosterone; Corticosterone; Deoxycorticosterone acetate; Dexamethasone acetate; Estradiol, 17B-; Hydrocortisone; Progesterone; Spironolactone; Testosterone; PEG; PEG 400; PEG 600; IP; rat; 1701; no duration posted; 3-7 days aldosterone, 6 days PEG only; replacement therapy (adrenalectomy).

top of page