References on the Administration of Erythropoietin Using ALZET^® Osmotic Pumps

P8429 Frederiksen,B.L., Caye-Thomasen,P., Lund,S.P., Wagner,N., Asal,K., Olsen,N.V., Thomsen,J. Does erythropoietin augment noise induced hearing loss?. Hearing Research 2007; 223(-1-2-):129-137. >>> Erythropoietin; Ear (round window); Guinea-Pig; 1007D; 1 week; Controls received mp w/ saline; replacement therapy (noise-induced hearing impairment); comparison of acute admin. vs. mp; peptides; animal info (male, Dunkin-Hartley); mp primed 6 hours in 37 Celsius saline; correct catheter placement confirmed; tissue perfusion (round window).

P7614 Malhotra,S., Savitz,S.I., Ocava,L., Rosenbaum,D.M. Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack. Journal of Neuroscience Research 2006; 83(-1-):19-27. >>> Erythropoietin receptor, soluble; PBS; BSA; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (male, Wistar, 200-225 g, MCA occlusion).

P5948 Prass,K., Scharff,A., Ruscher,K., Loewl,D., Muselmann,C., Victorov,I., Kapinya,K., Dirnagl,U., Meisel,A. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003; 34(-8-):1981-1986. >>> Erythropoietin, soluble receptor; PBS; BSA; CSF/CNS; Mice; 1003D; 64 hours; Controls received mp w/ vehicle; peptides; ischemia (cerebral); human EPO used; 0.1%BSA used in vehicle.

P5801 Shingo,T., Sorokan,S.T., Shimazaki,T., Weiss,S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 2001; 21(-24-):9733-9743. >>> Erythropoietin; antibody, rabbit anti-EPO neutralizing; rabbit IgG; Saline; albumin, mouse serum; rat serum; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; peptides; Erythropoietin (EPO) Recomb. Human, antibody&IgG were dissolved in 0.9% saline with 1 mg/ml mouse serum albumin; pump/cannula schematic (p. 9739 fig A).

P4619 Walker,B.R., Resta,T.C, Nelin,L.D  Am.J.Physiol.(Heart Circ.Physiol.) 2000; 279(--):H2382-H2389. >>> Erythropoietin; Saline; rat; 2 weeks; controls received mp w/vehicle; peptides; cardiovascular.

P4291 Roeder,I., de Haan,G., Engel,C., Nijhof,W., Dontje,B., Loeffler,M. Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 1998/5/1; 91(-9-):3222-3229. >>> Interleukin-11; Stem cell factor; Colony-stimulating factor, G; Erythropoietin;; SC;; mice;; 2002; 1007D;; 7 days;; controls received mp w/ saline; functionality of mp verified by pilot studies; no stress (see pg. 3223); peptides; recomb. human interleukin-11, EPO,&G-CSF used; recomb. rat stem cell factor used (pegylated);agents were given in every combination;.

P2546 de Haan,G., Engel,C., Dontje,B., Loeffler,M., Nijhof,W. Hemotoxicity by prolonged etoposide administration to mice can be prevented by simultaneous growth factor therapy. Cancer Res. 1995; 55(--):324-329. >>> Erythropoietin; Colony-stimulating factor, G; Etoposide; SC; mice; 7 days; dose-response curves (pg. 326-328); cancer; peptides; etoposide is VP-16-213; EPO and VP-16-213 given in same pump initially, but this inactived the G-CSF; multiple pumps per animal (1-2) for G-CSF/VP-16 mice.

P2737 Hoffman,A., Nyska,A., Avramoff,A., Golomb,G. Continuous versus pulsatile administration of erythropoietin (EPO) via the uterus in anemic rats. Int.J.Pharmaceutics 1994; 111(--):197-202. >>> Erythropoietin; intrauterine; rat; 2002; 5 days; controls received intrauterine bolus of saline; replacement therapy (gentamicin-induced anemia); comparison of iv bolus and intrauterine bolus vs. mp; peptides; mp implanted subdermally in abdomen; "administration of drug at a constant rate produces considerably greater biological effect than that observed in the pulsatile mode." (pg. 200); tissue perfusion (uterus); recomb. human EPO used.

P2523 Berney,T., Shibata,T., Merino,R., Chicheportiche,Y., Kindler,V., Vassalli,P., Izui,S. Murine autoimmune hemolytic anemia resulting from Fc-gamma receptor-mediated erythrophagocytosis: protection by erythropoietin but not by interleukin-3, and aggravation by granulocyte-macrophage colony-stimulating factor. Blood 1992; 79(-11-):2960-2964. >>> Erythropoietin; Interleukin-3; Colony-stimulating factor, GM; PBS; Glycerol; SC; mice; 2002; 14 days; immunology; peptides.

P2970 Shibata,T., Kindler,V., Chicheportiche,Y., Vassalli,P., Izui,S. Interleukin 3 perfusion prevents death due to acute anemia induced by monoclonal antierythrocyte autoantibody. J.Exp.Med. 1990; 171(--):1809-1814. >>> Interleukin-3; Colony-stimulating factor, GM; Erythropoietin; PBS; Glycerol; LPS, e. coli; SC; mice; 2002; no duration posted; controls received mp with vehicles +/- LPS; immunology; peptides; recomb. mouse GM-CSF&IL-3 used; recomb. human EPO used.

P0016 McGarry,M.P., Styles,B.D. Application of continuous flow osmotic minipumps in the study of hemopoietic regulators. Exp.Hematol. 1978; 6(-10-):809-811. >>> Erythropoietin; SC; Mice; 1701; 7; comparison of injections vs. mp infusion; peptides.

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