References on the Administration of Growth Hormone and Somatomedin Using ALZET^® Osmotic Pumps

1. Growth Hormone (all)

P8049 Kleinberg,D.L., Ruan,W.F., Yee,D., Kovacs,K.T., Vidal,S. Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice. Endocrinology 2007; 148(-3-):1080-1088. >>> Insulin-like growth factor-1; growth hormone, bovine; insulin-like growth factor-1, binding protein; SC; Mice; 1007D; 7 days; Controls received mp w/ saline; peptides; animal info (ORX, 10 weeks old, male); drugs delivered alone or in combination.

P8102 de Celix,A.D.R., Chowen,J.A., Argente,J., Frago,L.M. Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. Journal of Neurochemistry 2006; 99(-3-):839-849. >>> Growth hormone releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 200-250g.).

P7932 Zeinoaldini,S., Swarts,H.J.M., Van de Heijning,B.J.M. Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat. REGULATORY PEPTIDES 2006; 134(-2-3-):158-163. >>> Growth hormone, recomb. human; immunoglobulin G, goat; growth hormone, anti-rat; Saline, sterile; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; post op. care (analgesia, ibuprofen); animal info (female, Wistar, 45 grams).

P7903 Holloway,M.G., Laz,E.V., Waxman,D.J. Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4 alpha. MOLECULAR ENDOCRINOLOGY 2006; 20(-3-):647-660. >>> Growth hormone, recomb. rat; Saline; albumin, rat; sodium bicarbonate; SC; Mice; 1003D; 1007D; 1002; 1,2,4,7,14 days; 10 hours; Controls received mp w/ vehicle; peptides; animal info (male, female, ICR, 8-10 wk. old).

P7820 Cheung,C., Yu,A.M., Chen,C.S., Krausz,K.W., Byrd,L.G., Feigenbaum,L., Edwards,R.J., Waxman,D.J., Gonzalez,F.J. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. Journal of Pharmacology and Experimental Therapeutics 2006; 316(-3-):1328-1334. >>> Growth hormone, recomb. mouse; SC; Mice (transgenic); 1 week; Controls received sham surgery; peptides; animal info (male, female, C57BL/6 wt or CYP3A4/CYP3A7 Tg, 7wk old).

P7744 Simon,F.R., Iwahashi,M., Hu,L.J., Qadri,I., Arias,I.M., Ortiz,D., Dahl,R., Sutherland,E. Hormonal regulation of hepatic multidrug resistance-associated protein 2 (Abcc2) primarily involves the pattern of growth hormone secretion. American Journal of Physiology-Gastrointestinal and Liver Physiology 2006; 290(-4-):G595-G608. >>> Growth hormone; Sodium phosphate buffer; NaN2; glycerol; SC; Rat; mice; 2001; 7 days; Controls received sham surgery; replacement therapy (hypophysectomy); comparison of SC injections vs. mp; peptides; animal info (adult, Sprague-Dawley, male, female, 170-225g.).

P7539 Jarukamjorn,K., Sakuma,T., Jaruchotikamol,A., Ishino,Y., Oguro,M., Nemoto,N. Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver. Toxicology 2006; 219(-1-3-):97-105. >>> Growth hormone, recomb. human; Saline, normal; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; peptides; animal info (C57BL/6, male and female, 8 wk old); "Continuous GH administration allowed the GH level to be maintained relatively stably in the circulation compared with pulsatile GH administration". (p. 104).

P7613 Frago,L.M., Paneda,C., Argente,J., Chowen,J.A. Growth hormone-releasing peptide-6 increases insulin-like growth factor-I mRNA levels and activates Akt in RCA-6 cells as a model of neuropeptide Y neurones. Journal of Neuroendocrinology 2005; 17(-11-):701-710. >>> Growth hormone-releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, wistar 200-250 g); ghrelin receptor agonist.

P7492 Matasconi,M., Panini,P., Angelin,B., Rudling,M. Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: Effects of hypophysectomy and growth hormone treatment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2005; 1736(-3-):221-227. >>> Growth hormone, human; SC; Mice; 2001; 7 days; Controls received sham operation; replacement therapy (hypophysectomy); peptides; animal info (C57B1/6J, LDL R knockout, male).

P7405 Fruchtman,S., Simmons,J.G., Michaylira,C.Z., Miller,M.E., Greenhalgh,C.J., Ney,D.M., Lund,P.K. Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 2005; 289(-2-):G342-G350. >>> Insulin-like growth factor I-; growth hormone; Saline; SC; Mice (knockout); 5 days; Controls received mp w/ vehicle; peptides.

P7350 Slagter,B.J., Kittilson,J., Sheridan,M.A. Expression of somatostatin receptor mRNAs is regulated in vivo by growth hormone, insulin, and insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss). REGULATORY PEPTIDES 2005; 128(-1-):27-32. >>> Growth hormone, recomb. bovine; insulin, recomb. bovine; insulin-like growth factor. recomb. human; NaCl; IP; Fish (rainbow trout); 1007D; 21 days; Controls received mp w/ vehicle; peptides; post op. care (topical antibiotic ointment); at 14 degrees celsius, the 1007D infuses at 0.14 ul/hr for approximately 21 days.

P7171 Bennett,E., McGuinness,L., Gevers,E.F., Thomas,G.B., Robinson,I.C.A.F., Davey,H.W., Luckman,S.M. Hypothalamic STAT proteins: Regulation, of somatostatin neurones by growth hormone via STAT5b. Journal of Neuroendocrinology 2005; 17(-3-):186-194. >>> Growth hormone, recomb.bovine; Saline; SC; Rat; 8 days; Controls received mp w/ vehicle, replacement therapy (dwarf), comparison of IP inections vs. mp.

P7043 Ameen,C., Linden,D., Larsson,B.M., Mode,A., Holmaeng,A., Oscarsson,J. Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004; 287(-6-):E1039-E1048. >>> Growth hormone, recomb. bovine; Phosphate buffer; SC; Rat; 2001; 7 days; Controls received no treatment; replacement therapy (hypophysectomy); comparison of SC injections vs. mp; peptides; "Continuous administration of GH, but not two daily injections of GH, resulted in increased triglyceride biosynthesis and VLDL assembly in isolated rat hepatocytes." (pg. E1039).

P6982 Simon,F.R., Fortune,J., Iwahashi,M., Qadri,I., Sutherland,E. Multihormonal regulation of hepatic sinusoidal Ntcp gene expression. American Journal of Physiology-Gastrointestinal and Liver Physiology 2004; 287(-4-):G782-G794. >>> Growth hormone, recomb. bovine; Sodium phosphate; glycerol; sodium nitrate; SC; Rat; 2001; 7 days; Controls received sham treatment; replacement therapy (adrenalectomy, ovariectomy, hypophysectomy, thyroidectomy, castration); comparison of SC injections vs. mp; peptides.

P6852 Kotokorpi,P., Gardmo,C., Nystroem,C.S., Mode,A. Activation of the glucocorticoid receptor or liver X receptors interferes with growth hormone-induced akr1b7 gene expression in rat hepatocytes. Endocrinology 2004; 145(-12-):5704-5713. >>> Growth hormone, bovine; Rat; 2001; 6 days; Replacement therapy (hypophysectomy); peptides.

P6848 Kamegai,J., Tamura,H., Shimizu,T., Ishii,S., Tatsuguchi,A., Sugihara,H., Oikawa,S., Kineman,R.D. The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology 2004; 145(-8-):3731-3738. >>> Growth hormone, rat; insulin-like growth factor I, recomb. human; Saline; SC; Rat; 1003D; 72 hours; Controls received mp w/ vehicle; peptides.

P6684 Sakuma,T., Kitajima,K., Nishiyama,M., Endo,Y., Miyauchi,K., Jarukamjorn,K., Nemoto,N. Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones. Biochemical and Biophysical Research Communications 2004; 314(-2-):495-500. >>> Growth hormone, recomb. human; SC; Mice; 1007D; 7 days; Functionality of mp verified by weight gain; replacement therapy (adrenalectomy); peptides.

P6639 Bains,R.K., Wells,S.E., Flavell,D.M., Fairhall,K.M., Strom,M., Le Tissier,P., Robinson,I.C.A.F. Visceral obesity without insulin resistance in late-onset obesity rats. Endocrinology 2004; 145(-6-):2666-2679. >>> Growth hormone, human; SC; Rat; 4 weeks; Controls received no treatment; replacement therapy (GH deficiency); pumps replaced on day 13; peptides.

P6509 Ahluwalia,A., Clodfelter,K.H., Waxman,D.J. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. MOLECULAR ENDOCRINOLOGY 2004; 18(-3-):747-760. >>> Growth hormone, rat; Rat; 7 days; Controls received no treatment; peptides; pump model not listed.

P6406 Cunnningham,M.J., Krasnow,S.M., Gevers,E.F., Chen,P., Thompson,C.K., Robinson,I.C.A.F., Smith,M.S., Clifton,D.K., Steiner,R.A. Regulation of galanin-like peptide gene expression by pituitary hormones and their downstream targets. Journal of Neuroendocrinology 2004; 16(-1-):10-18. >>> Growth hormone, recomb. human; SC; Rat; 2002; 2 weeks.

P6387 Matasconi,M., Angelin,B., Rudling,M. Pituitary control of lipoprotein and bile acid metabolism in male rats: growth hormone effects are not mediated by prolactin. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004; 287(-1-):E114-E119. >>> Growth hormone, human; growth hormone, bovine; SC; Rat; 2001; 7 days; Replacement therapy (hyphophysectomy); dose-response (p. E115).

P6600 Paneda,C., Arroba,A.I., Frago,L.M., Holm,A.M., Romer,J., Argente,J., Chowen,J.A. Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats. NeuroReport 2003; 14(-12-):1633-1635. >>> Growth hormone-rel. peptide-6; IV (external jugular); Rat; 2ML1; 7 days; Controls received mp w/ saline; peptides; GHRP-6 is a synthetic ligand for the ghrelin receptor.

P6334 Ameen,C., Oscarsson,J. Sex difference in hepatic microsomal triglyceride transfer protein expression is determined by the growth hormone secretory pattern in the rat. Endocrinology 2003; 144(-9-):3914-3921. >>> Growth hormone, recomb. bovine; Phosphate buffer; glycerol; sodium azide; SC; Rat; 2001; 7 days; Controls were age matched normal and Hx rats; replacement therapy (hypophysectomy); comparison of sc injections vs. mp.

P6263 Dhir,R.N., Shapiro,B.H. Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003; 100(-25-):15224-15228. >>> Growth hormone, human; IP; Rat; 1007D; 7 days; Peptides.

P6090 Mesotten,D., Van de Berghe,G., Liddle,C., Coulter,S., McDougall,F., Baxter,R.C., Delhanty,P.J.D. Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis. Endocrinology 2003; 144(-9-):4008-4017. >>> Growth Hormone; Saline; SC; Rat; 1003D; 4 days; Controls received mp w/ vehicle; GH was recomb human.

P6088 Ornerovic,E., Bollano,E., Lorentzon,M., Walser,M., Mattsson-Hulten,L., Isgaard,J. Growth hormone induces myocardial expression of creatine transporter and decreases plasma levels of IL-1β in rats during early postinfarct cardiac remodeling. GROWTH HORMONE&IGF RESEARCH 2003; 13(-5-):239-245. >>> Growth hormone; Saline; SC; Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; GH was recomb human.

P5894 Jalouli,M., Carlsson,L., Ameen,C., Linden,D., Ljungberg,A., Michalik,L., Eden,S., Wahli,W., Oscarsson,J. Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: Influence of pituitary and gonadal hormones. Endocrinology 2003; 144(-1-):101-109. >>> Growth hormone, bovine; testosterone; estradiol, 17B-; Phosphate buffer; glycerol; sodium asize; propylene glycol; SC; Rat; 2001; 7 days; Replacement therapy (gonadectomy); comparison of daily injections vs. chronic mp; peptides; GH was recomb bovine&diluted in 0.05 m phosphate buffer, ph 8.6, with 1.6% glycerol&0.02% sodium azide; testosterone&estradiol were diluted in propylene glycol.

P5826 Obal,F.Jr, Alt,J., Taishi,P., Gardi,J., Krueger,J.M. Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-1-):R131-R139. >>> Growth hormone, mouse; growth hormone, rat; Saline; SC; Mice; 1002; 14 days; Functionality of mp verified by IGF-1 plasma levels; peptides.

P5810 Hedlund,G.P., Carlsson,H.E., Shieck,E., Nilsson,I., Lundblad,C., Arons,S., Iversen,A.K., Looman,C., Jensen,H.E., Hau,J. Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland. In Vivo 2003; 17(-1-):1-4. >>> Growth hormone, recomb. human; thyroxine; triiodothyronine; SC; Rat; 7 days; Controls received teflon rods; replacement therapy (hypophysectomy).

P5590 Gevers,E.F., Loveridge,N., Robinson,I.C.A.F. Bone marrow adipocytes: A neglected target tissue for growth hormone. Endocrinology 2002; 143(-10-):4065-4073. >>> Growth hormone; Insulin-like growth factor I; Parathyroid hormone (1-34); BSA; water; SC; rat; 2002; 2 weeks; replacement therapy (genetically GH-deficient rats); peptides.

P5581 Frick,F., Linden,D.N., Ameen,C., Eden,S., Mode,A., Oscarsson,J. Interaction between growth hormone and insulin in the regulation of lipoprotein metabolism in the rat. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2002; 283(-5-):E1023-E1031. >>> Growth hormone; PBS; Glycerol; Sodium azide; SC; rat; 2001; 7 days; replacement therapy (hypophysectomy).

P5580 Frago,L.M., Paneda,C., Dickson,S.L., Hewson,A.K., Argente,J., Chowen,J.A. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology 2002; 143(-10-):4113-4122. >>> Growth hormone; Growth hormone-rel. peptide; IV (jugular); rat; 2001; 7 days; controls received mp with saline; peptides.

P5510 Zoidis,E., Gosteli-Peter,M., Ghirlanda-Keller,C., Meinel,L., Zapf,J., Schmid,C. IGF-I and GH stimulate Phex mRNA expression in lungs and bones and 1,2 5-dihydroxyvitamin D-3 production in hypophysectomized rats. European Journal of Endocrinology 2002; 146(-1-):97-105. >>> Growth hormone; Insulin-like growth factor I; Acetic acid; SC; Rat; 2001; 2 days; Controls received mp w/ vehicle; functionality of mp verified by IGF-I plasma levels; replacement therapy (hypohysectomy); peptides.

P5402 Zapf,J., Gosteli-Peter,M., Weckbecker,G., Hunziker,E.B., Reinecke,M. The somatostatin analog octreotide inhibits GH-stimulated, but not IGF-I-stimulated, bone growth in hypophysectomized rats. Endocrinology 2002; 143(-8-):2944-2952. >>> Insulin-like growth factor I; growth hormone, human; octreotide; Sodium acetate; benzylalcohol; water; SC; Rat; 2001; 6 days; Controls received mp w/ vehicle; functionality of mp verified by IGF-I plasma levels; peptides; recomb. human IGF-I and recomb. human GF used; some animals received 2 pumps: one with octreotide and one with GH.

P5378 Sakuma,T., Endo,Y., Mashino,M., Kuroiwa,M., Ohara,A., Jarukamjorn,K., Nemoto,N. Regulation of the expression of two female-predominant CYP3A mRNAs (CY P3A41 and CYP3A44) in mouse liver by sex and growth hormones. Archives of Biochemistry and Biophysics 2002; 404(-2-):234-242. >>> Growth hormone, recomb. human; SC; Mice; 1007D; 7 days; Replacement therapy (orchidectomy or hypophysectomy); comparison of twice-daily SC injections vs mp; peptides.

P5312 Simon,F.R., Fortune,J., Iwahashi,M., Sutherland,E. Sexual dimorphic expression of ADH in rat liver: importance of the hypothalamic-pituitary-liver axis. American Journal of Physiology-Gastrointestinal and Liver Physiology 2002; 283(-3-):G646-G655. >>> Growth hormone, bovine; Na2PO4; Glycerol; NaN2; Rat; 2001; 7 days; Comparison of twice-daily injections vs. mp.

P5120 Sahlin,L., Elger,W., Hedden,A., Lindberg,M., Reddersen,G., Schneider,B., Schwarz,S., Freyschuss,B., Eriksson,H. Effects of estradiol and estradiol sulfamate on the liver of ovariectomized or ovariectomized and hypophysectomized rats. Journal of Steroid Biochemistry and Molecular Biology 2002; 80(--):457-467. >>> Estradiol, 17B-; Estradiol sulfamate; Dexamethasone; Growth hormone, human; Propylene glycol; SC; rat; 2001; 7 days; controls received mp w/ vehicle; replacement therapy (ovariectomy, hypophysectomy, p. 458); comparison of oral administration vs. mp; steroid administered in PG, human GH pre-formulated.

P5083 Delhanty,P.J.D., Mesotten,D., McDougall,F., Baxter,R.C. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology 2002; 143(-6-):2445-2448. >>> Growth hormone, human; Growth hormone, porcine;; SC; rat; 24-48 hours; comparison of IP injections vs. mp; peptides; porcine or recomb. human GH used.

P6714 Oscarsson,J., Gardmo,Cissi, Eden,S., Mode,A. Pulsatile growth hormone secretion decreases S-adenosylmethionine synthetase in rat liver. Am J Physiol Endocrinol Metab 2001; 280(--):E280-E286. >>> Growth hormone, recomb. bovine; SC; Rat; 2001; 6,7 days; Replacement therapy (hypophysectomy); comparison of SC injections vs. mp;.

P5757 Rudling,M., Angelin,B. Growth hormone reduces plasma cholesterol in LDL receptor-deficient mice. FASEB J 2001; 15(-8-):1350-1356. >>> Growth hormone, human; SC; Mice; 2001; 6 days; Peptides.

P4893 Conlon,M.A., Kita,K. Porcine growth hormone and LongR (3)IGF-I can improve recovery from surgery-induced weight loss in guinea pigs. General and Comparative Endocrinology 2001; 123(--):332-336. >>> Growth hormone, porcine; Insulin-like growth factor I analog; Disodium hydrogen orthophosphate; Acetic acid; SC; guinea-pig; 2001; 7 days; controls received mp w/ vehicle; functonality of mp verified by serum drug levels; dose response (text, graph p. 334-5); peptides; LR3IGF-1 is an IGF-I analog; multiple pumps per animal (2), one containing each solution; pGH was dissolvd in 0.1M disodium hydrogen orthophosphate; L3IGF-1 was dissolved in 0.1 M acetic acid.

P4778 Pampori,N.A., Agrawal,A.K., Shapiro,B.H. Infusion of gender-dependent plasma growth hormone profiles into intact rats: Effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic CYP isoforms.. Drug Metabolism and Disposition 2001; 29(-1-):8-16. >>> Growth hormone, recomb.; Growth hormone, human;; SC; IP;; rat;; 7 days;; Controls received mp w/ vehicle; dose-response (p. 13 graphs); peptides; plasma GH differences by gender; both SC and IP routes used;.

P4967 Tollet-Egnell,P., Flores-Morales,A., Odeberg,J., Lundeberg,J., Norstedt,G. Differential cloning of growth hormone-regulated hepatic transcripts in the aged rat. Endocrinology 2000; 141(--):910-921. >>> Growth hormone, human; rat; 2004; 3 weeks; controls received mp w/ vehicle; replacement therapy (hypophysectomy p. 911); peptides; recomb. human GH used;.

P4717 Hausman,G.J., Richardson,R.L, Simmen,F.A. Expression of insulin-like growth factor binding proteins (IGFBPs) before and during the hormone sensitive period of adipose tisue development in the fetal pig.. Growth, Development, and Aging 2000; 64(--):51-67. >>> Growth hormone, recomb. porcine;; pig (fetus);; ; Functionality of mp verified by plasma levels; replacement therapy (hypophysectomy); teratology; peptides; pellets used for thyroxine administration..

P4663 Reinecke,M, Schmid,A.C, Heyberger-Meyer,B, Hunziker,E.B., Zapf,J. Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo.. Endocrinology 2000; 141(-8-):2847-2853. >>> Insulin-like growth factor I, recomb. human-; Growth hormone, recomb. human-;; Acetic acid;; SC;; rat;; 2002;; 24 hours;; functionality of mp verified by IGF-I serum levels; peptides..

P4550 Sigalet,D.L., Martin,G.R. Hormonal therapy for short bowel syndrome.. Journal of Pediatric Surgery 2000/2; 35(--):360-364. >>> Growth hormone; Insulin-like growth factor I; Glucagon-like peptide-2;; Saline;; SC;; rat;; 2ML1;; 14 days;; controls received mp w/vehicle; no stress (P. 361); peptides;.

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2. Growth Hormone, Bovine

P5810 Hedlund,G.P., Carlsson,H.E., Shieck,E., Nilsson,I., Lundblad,C., Arons,S., Iversen,A.K., Looman,C., Jensen,H.E., Hau,J. Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland. In Vivo 2003; 17(-1-):1-4. >>> Growth hormone, bovine; Na2PO4; Glycerol; NaN2; Rat; 2001; 7 days; Comparison of twice-daily injections vs. mp.

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3. Growth Hormone, Chicken

P4547 Scanes,C.G., Proudman,J.A, Radecki,S.V. Influence of continuous growth hormone or insulin-like growth factor I administration in adult female chickens.. General and Comparative Endocrinology 1999; 114(--):315-323. >>> Growth hormone, chicken; Insulin-like growth factor I;; Saline; Albumin, bovine serum;; SC;; bird (chicken);; 2ML2;; 10 days;; controls received mp w/vehicle; functionality of mp verified by plasma levels; peptides; recomb. chicken growth hormone used;.

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4. Growth Hormone, Human

P5757 Rudling,M., Angelin,B. Growth hormone reduces plasma cholesterol in LDL receptor-deficient mice. FASEB J 2001; 15(-8-):1350-1356. >>> Growth hormone, human; SC; Mice; 2001; 6 days; Peptides.

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5. Growth Hormone, Ovine

P6300 McCormick,S.D. Effects of Growth Hormone and Insulin-like Growth Factor I on Salinity Tolerance and Gill Na+, K+-ATPase in Atlantic Salmon (Salmo salar): Interaction with Cortisol. General and Comparative Endocrinology 1996; 101(--):3-11. >>> Growth hormone, ovine; insulin-like growth factor I, recomb. bovine; Ringer's solution; Fish (atlantic salmon); 1003D; 4-14 days.

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6. Growth Hormone, Porcine

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7. Growth Hormone, Rat

P4423 Kamegai,J, Unterman,T.G, Frohman,L.A, Kineman,R.D. Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormome (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid. Endocrinology 1998; 139(--):3554-3560. >>> Growth hormone, rat; Insulin-like growth factor I;; Saline;; SC;; rat;; 1003D;; 72 hours;; controls received mp w/vehicle; functionality of mp verified by serum levels; recomb. human IGFI used;.

P3963 Pampori,N.A., Shapiro,B.H. Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. Mol.Pharmacol. 1996; 50(--):1148-1156. >>> Growth hormone, rat; Thyroxine; SC; IP; rat; 6 days; functionality of mp verified by residual volume; replacement therapy (hypophysectomy); peptides; multiple pumps per animal (2) (1 with each agent).

P3258 Labrie,Y., Couet,J., Simard,J., Labrie,F. Multihormonal regulation of dehydroepiandrosterone sulfotransferase messenger ribonucleic acid levels in adult rat liver. Endocrinology 1994; 134(-4-):1693-1699. >>> Growth hormone, rat; Saline; SC; rat; 2001; 7 days; replacement therapy (hypophysectomy); comparison of injections vs. mp; peptides.

P3162 Hursting,S.D., Switzer,B.R., French,J.E., Kari,F.W. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis 1994; 15(-2-):193-199. >>> Growth hormone, rat; Saline; BSA; SC; rat; 2001; no duration posted; controls received mp with saline; cancer; toxicology; peptides.

P2944 Schlechter,N.L., Katz,L.S., Russell,S.M., Nicoll,C.S. Physiological evaluation of the role of the liver as a mediator of the growth-promoting action of somatotrophin. Zoological Science 1993; 10(--):235-244. >>> Growth hormone, human; Growth hormone, bovine; Growth hormone, rat; IV (jugular); IV (portal); rat; 2001; 7 Days; controls received mp with solvent or sham operation; replacement therapy (hypophysectomy); pulsed delivery; catheter contained heparin.

P2359 Meseguer,A., Catterall,J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol.and Cellular Endocrin. 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; 7 days; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

P1459 MacLeod,J.N., Shapiro,B.H. Growth hormone regulation of hepatic drug-metabolizing enzymes in the mouse. Biochem.Pharmacol. 1989; 38(-10-):1673-1677. >>> Growth hormone, rat; Sodium bicarbonate; Sodium chloride; Water; SC; mice; 2001; 7 days; dose-response; comparison of sc injections vs. mp infusion; functionality of mp verified in vitro by RIA; replacement therapy (hypophysectomy); peptides.

P1426 Orlowski,C.C., Chernausek,S.D. Discordance of serum and tissue somatomedin levels in growth hormone-stimulated growth in the rat. Endocrinology 1988; 123(-1-):44-49. >>> Growth hormone, rat; Saline; Serum, rat; Sodium bicarbonate; SC; rat; 2001; 4 days; controls received sham surgery; comparison of 2x daily sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1330 Maiter,D., Underwood,L.E., Maes,M., Davenport,M.L., Ketelslegers,J.M. Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor 1 and liver GH receptors in hypophysectomized rats. Endocrinology 1988; 123(-2-):1053-1059. >>> Growth hormone, rat; Saline; SC; rat; 2001; 7 days; dose-response (graph); comparison of sc injections vs. mp infusion; functionality of mp verified by serum levels; replacement therapy (hypophysectomy); peptides.

P1094 Quail,J.A., Jellinck,P.H. Modulation of catechol estrogen synthesis by rat liver microsomes: Effects of treatment with growth hormone or testosterone. Endocrinology 1987; 121(--):987-992. >>> Growth hormone, bovine; Growth hormone, human; Growth hormone, ovine; Growth hormone, rat; Saline; Sodium bicarbonate; SC; rat; 2001; 7 days; GH, in some cases dissolved in sodium bicarbonate; agents infused separately; peptides.

P1005 Norstedt,G., Husman,B., Mode,A., Eneroth,P., Lewis,U.J., Gustafsson,J.-A. Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides. Acta Endocrinol. 1987; 114(--):350-356. >>> Prolactin, human; Growth hormone, bovine; Growth hormone, human; Growth hormone, rat; Lactogen, human placental; Prolactin, ovine; Prolactin, rat; 125I tracer; Saline; Sodium bicarbonate; Sodium carbonate; Tris buffer; SC; rat; 2001; 2ML1; 1 week; mp w/vehicle; peptides; replacement therapy (hypophysectomy).

P0977 Tatro,J.B., Schwartz,J. Metabolic effects of acute and prolonged growth hormone deficiency in streptozotocin-diabetic rats. Endocrinology 1987; 120(--):373-380. >>> Growth hormone, anti-rat; Nonimmunized sera; IP; rat; 2ML1; 5 days; controls received mp w/vehicle; comparison of ip injections vs. mp infusion; peptides.

P2427 Schlechter,N.L., Russell,S.M., Spencer,E.M., Nicoll,C.S. Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc.Natl.Acad.Sci. 1986; 83(--):7932-7934. >>> Growth hormone, rat; Somatomedin C, human; Serum, rabbit; Antiserum, human somatomedin C, rabbit; Glycerol; Sodium azide; Water, double-distilled; Sodium heparin; IA (right superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); peptides; minipump and catheter were implanted in abdominal cavity; some rats received co-infusion of GH and rabbit serum or antiserum.

P0895 Scott,C.D., Baxter,R.C. Production of insulin-like growth factor I and its binding protein in rat hepatocytes cultured from diabetic and insulin-treated diabetic rats. Endocrinology 1986; 119(-5-):2346-2352. >>> Growth hormone, rat; Insulin; SC; rat; 2001; 2002; up to 14 days; controls were untreated; peptides.

P0771 Schlechter,N.L., Russell,S.M., Greenberg,S., Spencer,E.M., Nicoll,C.S. A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion. Am.J.Physiol. 1986; 250(--):E231-E235. >>> Growth hormone, rat; Prolactin, ovine; Glycerol; Sodium azide; IA (superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); mp connected to catheter in superior vesicle artery; detailed description and diagram of catheter apparatus; constant and pulsed delivery of GH; peptides.

P0688 MacGeoch,C., Morgan,E.T., Gustafsson,J.-A. Hypothalamo-pituitary regulation of cytochrome P-450(15B) apoprotein levels in rat liver. Endocrinology 1985; 117(-5-):2085-2092. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; SC; rat; 2001; 2ML1; 1 week; comparison of twice daily sc injec of rat GH vs. mp infusion; replacement therapy (hyposphysectomy); controls received sham mp made of silicone; tubing; peptides.

P0581 Scott,C.D., Martin,J.L., Baxter,R.C. Rat hepatocyte insulin-like growth factor I and binding protein: effect of growth hormone in vitro and in vivo. Endocrinology 1985; 116(-3-):1102-1107. >>> Growth hormone, rat; SC; rat; 2001; 5 days; replacement therapy (hypophysectomy); peptides.

P0535 Baxter,R.C., Zaltsman,Z. Induction of hepatic receptors for growth hormone (GH) and prolactin by GH infusion is sex independent. Endocrinology 1984; 115(-5-):2009-2014. >>> Growth hormone, rat; Prolactin, rat; SC; rat; 1 week; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0483 Norstedt,G., Andersson,G., Gustafsson,J.-A. Growth hormone induction of lactogenic receptors at intracellular sites in male rat liver. Endocrinology 1984; 115(-2-):672-680. >>> Growth hormone, human; Growth hormone, rat; SC; rat; 2001; 2ML1; 1-7 days; replacement therapy (hypophysectomy); hGH used in 2001 mp, rGH used in 2ML1; peptides.

P0450 Baxter,R.C., Zaltsman,Z., Turtle,J.R. Rat growth hormone (GH) but not prolactin (PRL) induces both GH and PRL receptors in female rat liver. Endocrinology 1984; 114(-5-):1893-1901. >>> Growth hormone, ovine; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; comparison of agents effects; peptides.

P0230 Skett,P., Young,C. The effects of pituitary hormones on hepatic drug metabolism in the rat. Acta Endocrinol. 1982; 100(--):421-426. >>> Follitropin, rat; Thyrotropin, rat; Growth hormone, human; Growth hormone, rat; Pituitary extract; Prolactin, rat; Saline; Water; SC; rat; 1701; 6 days; organ replacement therapy (hypophysectomy); agents also injected - comparison of injec vs. mp infusion; peptides.

P0226 Schoenle,E., Zapf,J., Froesch,E.R. Glucose transport in adipocytes and its control by growth hormone in vivo. Am.J.Physiol. 1982; 242(--):E368-E372. >>> Growth hormone, human; Growth hormone, rat; Saline; SC; rat; 2001; 6 days; comparison of sc injec. vs. sc infusion; organ replacement therapy (hypophysectomy); peptides.

P0215 Norstedt,G. A comparison between the effects of growth hormone on prolactin receptors and estrogen receptors in rat liver. Endocrinology 1982; 110(-6-):2107-2112. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; organ replacement therapy (hypophysectomy); intermittent injections vs. infusion; peptides.

P0212 Pousette,A., Bjork,P., Carlstrom,K., Forsgren,B., Hogberg,B., Gustafsson,J.-A. Influence of pituitary and adrenocortical hormones on prostatic secretion protein, a major protein in rat prostate. The Prostate 1982; 3(--):109-114. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 2 weeks; replacement therapy (hypophysectomy); peptides.

P0148 Gustafsson,J.-A., Eneroth,P., Hokfelt,T., Mode,A., Norstedt,G., Skett,P. Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents. Environ.Health Perspect. 1981; 38(--):129-141. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; SC; rat; 7 days; replacement therapy (hypophysectomy); toxicology; peptides.

P0133 Mode,A., Norstedt,G., Simic,B., Eneroth,P., Gustafsson,J.-A. Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat. Endocrinology 1981; 108(-6-):2103-2108. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P0126 Norstedt,G., Mode,A., Eneroth,P., Gustafsson,J.-A. Induction of prolactin receptors in rat liver after the administration of growth hormone. Endocrinology 1981; 108(-5-):1855-1861. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

R0046 Skett,P., Young,C. The effect of pituitary hormones on hepatic drug metabolism. In 'Biochemistry, Biophysics and Regulation of Cytochrome P-450,' J.-A.Gustafsson, J.Carlstedt-Duke, A.Mode, and J.Rafter (eds.), Elsevier/North-Holland, Amsterdam 1980; (--):195-198. >>> Enkephalin analog DADLE; Follicle stimulating hormone; Growth hormone, bovine; Growth hormone, rat; Pituitary extract; Prolactin, bovine; Prolactin, rat; Thyroid-stimulating hormone; Water; SC; rat; 1701; 1 week; peptides.

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8. Growth Hormone-rel. Factor

P3546 Roh,S-G., Matsunaga,N., Hidaka,S., Hidari,H. Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves. Endocrine J. 1996; 43(-3-):291-298. >>> Growth hormone-rel. factor-2; DMSO; PEG 400; Tween 80; Saline; SC; cattle; 2ML2; 14 days; controls received mp w/ vehicle; peptides; agent also called KP102; multiple pumps per animal (3 or 4); comparison between injections vs. mp.

P2946 Sato,M., Murao,K., Niimi,M., Tamaki,M., Takahara,J. Effects of long-term infusion of growth hormone (GH)-releasing factor on pulsatile GH secretion in the male rat. Life Sci. 1993; 54(-2-):79-86. >>> Growth hormone-rel. factor (1-44) -NH2, human; IV (femoral); rat; 2002; 14 days; comparison of acute infusion vs. mp; peptides; pumps placed near abdomen.

P2214 Stefaneanu,L., Kovacs,K., Horvath,E., Clark,R.G., Cronin,M.J. Effect of intravenous infusion of growth hormone-releasing hormone on the morphology of rat pituitary somatotrophs. Endocr.Pathol. 1993; 4(--):131-139. >>> Growth hormone-rel. factor; Acetate in PBS; IV; rat; 2001; 2ML2; 1 week; controls received mp w/vehicle.

P1742 Godfredson,J.A., Wheaton,J.E., Crooker,B.A., Wong,E.A., Campbell,R.M., Mowles,T.F. Growth performance and carcass composition of lambs infused for 28 days with a growth hormone-releasing factor analogue. J.Anim.Sci. 1990; 68(--):3624-3632. >>> Growth hormone-rel. factor analog; DMSO; Water; SC; sheep; 28 days; functionality of mp verified by measurement of residual volume; pumps replaced weekly; stability in vehicle verified at 37 degrees celsius for 7 days.

S1088 Su,C.-M., Jensen,L.R., Egan,T.J., Stricker,P., Mowles,T.F. Long term subcutaneous infusion of growth-hormone releasing factor (GRF) analog, Ro 23-7863, in rat. Presented at the 72nd Annual Meeting of the Endocrine Society, June 20-23, Atlanta, GA 1989; (--):117-. >>> Growth hormone-rel. factor analog; SC; rat; 2 weeks; functionality of mp verified by plasma levels of GRF; peptides.

S0937 Sato,M., Takahara,J., Niimi,M., Irino,S. Opposite effects of short-term and long-term continuous growth hormone-releasing factor (GRF) infusion on pulsatile growth hormone (GH) secretion in male rats. Presented at the 71st Annual Meeting of the Endocrine Society, June 21-24, Seattle, WA 1989; (--):772-. >>> Growth hormone-rel. factor; IV (femoral); rat; 14 days; peptides.

P1492 Wheaton,J.E., Al-Raheem,S.N., Godfredson,J.A., Dorn,J.M., Wong,E.A., Vale,W., Rivier,J., Mowles,T.F., Heimer,E.P., Felix,A.M. Use of osmotic pumps for subcutaneous infusion of growth hormone-releasing factors in steers and wethers. J.Anim.Sci. 1988; 66(--):2876-2895. >>> 4SG-29; RO-23-7863; Growth hormone-rel. factor; DMSO; Water; SC; cattle; sheep; 2002; 2ML1; 7 days; functionality of mp verified by plasma levels; peptides.

S0595 Arase,K., Ling,N., Bray,G. Suppressive effects of prepro-GRF on long-term feeding behavior in rats. Diabetes 1986; 35(-1-):161A-. >>> Growth hormone-rel. factor, prepro-; CSF/CNS; rat; no duration posted; comparison of injection vs. mp infusion; peptides.

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9. Somatomedin

P2457 Kirkeby,O.J., Ekeland,A. No effects of local somatomedin C on bone repair: continuous infusion in rats. Acta Orthop.Scand. 1992; 63(-4-):447-450. >>> Somatomedin C; Acetic acid; bone (medulla); rat; 2ML4; no duration posted; tissue perfusion (bone); peptides.

S0133 Rudman,C.G., Parsons,J.A. The influence of growth hormone and somatomedins A and B on patterns of incorporation of 14C-proline compared by autoradiography and combustion. Presented at the 63rd Annual Meeting of the Endocrine Society, June 17-19, Cincinnati, OH 1981; (--):164-. >>> Somatomedin B; Growth hormone, human; Somatomedin A; Hexanoic acid, 6-amino-; Water; SC; rat; 1 week; organ replacement therapy (hypophysectomy); peptides.

P0196 Rudman,C.G., Parsons,J.A. Autoradiographic comparison of growth factors: influence of growth hormone and somatomedin B on patterns of proline incorporation. Clin.Endocrinol. 1981; 15(--):319-324. >>> Somatomedin B; Growth hormone; HCl; Hexanoic acid, 6-amino-; Water; SC; rat; 1 week; organ replacement therapy (hypophysectomy); peptides.

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10. Somatostatin

P5015 Kramer,A., Yang,F.C., Snodgrass,P., Li,X., Scammell,T.E., Davis,F.C., Weitz,C.J. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 2001/12/21; 294(-5551-):2511-2515. >>> Transforming growth factor-a; Brain-derived neurotrophic factor; Vasoactive intestinal polypeptide; Peptide, histidine-isoleucine; Gastrin releasing peptide; Substance P; Neuromedin-C; Neurokinin A; Neuropeptide K; Neuropeptide Y; Somatostatin; Antrin; Cholecystokinin; Thyrotropin-releasing hormone; Neurotensin; Neuromedin N;; CSF, artificial; CSF/CNS (third ventricle); hamster; 2002; 18-22 days; peptides.

P4924 de Segura,A.G., Castell,T., Vazquez,I., Mata,A., De Miguel,E. Somatostatin antagonism prevents elemental diet-induced intestinal atrophy in the rat. Digestive Diseases and Sciences 2001; 46(-9-):1985-1992. >>> Somatostatin antagonist; Saline; IP; rat; 2ML1; 7 days; controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; comparison of sc injections vs. mp; peptides; The somatostatin antagonist is cyclo-7-aminoheptanoyl-phe-d-trp-lys-thr (also known as BZL); SC injections examined pulsatile administration of the agent; pump model 2ML1 used (2001 incorrectly listed);.

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References on the Administration of Growth Hormone and Somatomedin Using ALZET® Osmotic Pumps

1. Growth Hormone (all)

2. Growth Hormone, Bovine

3. Growth Hormone, Chicken

4. Growth Hormone, Human

5. Growth Hormone, Ovine

6. Growth Hormone, Porcine

7. Growth Hormone, Rat

8. Growth Hormone-rel. Factor

9. Somatomedin

10. Somatostatin

Sterile Catheter Tubing for Infusion Studies

References on the Administration of Growth Hormone and Somatomedin Using ALZET^® Osmotic Pumps