References on the Intravenous Administration of Agents Using
ALZET^® Osmotic Pumps

P8612 Ito,N., Ohishi,M., Yamamoto,K., Tatara,Y., Shiota,A., Hayashi,N., Komai,N., Yanagitani,Y., Rakugi,H., Ogihara,T. Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats. Am.J.Hypertens. 2007/7; 20(-7-):792-799. >>> Temocaprilat; olmesartan; hydralazine; IV (vena cava); Rat; 2ML4; 4 weeks; Controls received mp w/ saline; enzyme inhibitor (ACE); cardiovascular; antihypertensive; animal info (male, SHR, 50 weeks old, male, Wistar-Kyoto, 10 weeks old).

P8611 Itoh,T., Obata,H., Murakami,S., Hamada,K., Kangawa,K., Kimura,H., Nagaya,N. Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. American Journal of Physiology- Lung Cellular and Molecular Physiology 2007; 293(-2-):L446-L452. >>> Adrenomedullin, recomb. human; Saline; IV (jugular); Rat; 2001D; 8,20 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; no stress (see pg. L447); peptides; animal info (male, Sprague-Dawley, 180-200 grams, LPS-induced lung injury); "The animals showed no signs of distress with this procedure." (p. L447).

P8584 Boesen,E.I., Anderson,W.P., Kett,M.M. Acute pressure-natriuresis relationship following withdrawal of chronic noradrenaline infusion. Clin Exp.Pharmacol.Physiol 2007/9; 34(-9-):881-883. >>> Noradrenalin; Ascorbic acid; NaH2 P04; saline, heparinized; IV (vena cava); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; cardiovascular; animal info (male, Sprague-Dawley, adult).

P8521 LaMarca,B.D., Chandler,D.L., Grubbs,L., Bain,J., McLernore,GR Jr, Granger,J.P., Ryan,M.J. Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure. American Journal of Hypertension 2007; 20(-11-):1216-1221. >>> Tumor necrosis factor; Saline; heparin; IV; Rat; 2001; 5 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); cardiovascular; animal info (female, Sprague-Dawley, 15 weeks old).

P8479 Whalen,E.J., Foster,M.W., Matsumoto,A., Ozawa,K., Violin,J.D., Que,L.G., Nelson,C.D., Benhar,M., Keys,J.R., Rockman,H.A., Koch,W.J., Daaka,Y., Lefkowitz,R.J., Stamler,J.S. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 2007; 129(-3-):511-522. >>> Isoproterenol; GSNO; PBS; IV (jugular); Mice; ; Cardiovascular; agent is also known as nitrosoglutathione.

P8306 Tiranathanagul,K., Dhawan,V., Lytle,I.F., Zhang,W., Borschel,G.H., Buffington,D.A., Tziampazis,E., Brown,D.L., Humes,H.D. Tissue engineering of an implantable bioartificial hemofilter. ASAIO Journal 2007; 53(-2-):176-186. >>> Platelet-derived growth factor-BB; vascular endothelial growth factor 164; Saline, normal; albumin, rat serum; acetic acid; IA (femoral); IV (femoral); Rat; 2004; 28 days; Artificial kidney; controls received mp w/ vehicle; peptides; animal info (male, Fisher 344); mp attached by cannula to bioartificial hemofilter device, which surrounded and delivered agent to the femoral vessels; nephrology.

P8263 Nishimura,M., Takahashi,H., Yoshimura,M. Upregulation of the brain renin-angiotensin system in rats with chronic renal failure. ACTA PHYSIOLOGICA 2007; 189(-4-):369-377. >>> Candesartan; CSF, artificial; IV (jugular); CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle; replacement therapy (subtotal nephrectomy, dorsal rhizotomy); antihypertensive; cyanoacrylate adhesive; animal info (male, SHR/Izumo, 8 wks old, 300-350g.); ATI receptor antagonist.

P8224 Menon,J., Soto-Pantoja,D.R., Callahan,M.F., Cline,J.M., Ferrario,C.M., Tallant,E.A., Gallagher,P.E. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Research 2007; 67(-6-):2809-2815. >>> Angiotensin (1-7); Saline; heparin; IV (jugular); Mice (nude); 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 2810); cancer (lung); peptides; animal info (male, athymic, 2-4 weeks old, 15-20 grams); "During the infusion period, the animals maintained their body weight as well as food and water consumption and showed no evidence of reduced motor function. Additionally, no gross pathological abnormalities were observed in major organs..indicating a lack of toxic side effects." (p. 2810).

P8116 Goldman,J., Zhong,L., Liu,S.Q. Negative regulation of vascular smooth muscle cell migration by blood shear stress. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-2-):H928-H938. >>> PD-98095; ML-7; IV (vena cava); Rat; 2ML1; 5, 7 days; Enzyme inhibitor (MAP kinase-ERK kinase 1/2, myosin light chain kinase); animal info (male, Sprague-Dawley, 30. old, vein grafts).

P8080 Nagano,H., Wei,P.Z., Wen,C.Q., Jomori,T., Oku,H., Ikeda,T., Saito,Y., Tano,Y. Effects of kallidinogenase on ischemic changes induced by repeated intravitreal injections of endothelin-1 in rabbit retina. Current Eye Research 2007; 32(-2-):113-122. >>> Kallidinogenase; Saline; IV (marginal ear vein); Rabbit; 4 weeks; Controls received mp w/ vehicle; ischemia (retinal); animal info (male, New Zealand, 2.5-3.5 kg.).

P8338 Schaefer,M.B., Ott,J., Mohr,A., Bi,M.H., Grosz,A., Weissmann,N., Ishii,S., Grimminger,F., Seeger,W., Mayer,K. Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury - Role of platelet-activating factor receptor. Critical Care Medicine 2006; 35(-2-):544-554. >>> Saline, physiological; lipoven; omegaven; IV (jugular); Mice; 10 days; Controls received mp w/ saline, physiological; pumps replaced after 7 days of saline infusion; animal info (BALB/C wt, 8-12 weeks old, 18-21 grams, LPS induced acute lung injury and IP inflammation); mp contained an external device tied to the back; lipoven 10% (soybean oil); omegaven 10% (fish oil); lipid emulsion.

P8290 Brinkkoetter,P.T., Beck,G.C., Gottmann,U., Loesel,R., Schnetzke,U., Rudic,B., Hanusch,C., Rafat,N., Liu,Z.Z., Weiss,C., Leuvinik,H.G.D., Ploeg,R., Braun,C., Schnuelle,P., van der Woude,F.J., Yard,B.A. Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: Role of p42/p44 activation. Transplantation 2006; 82(-4-):534-542. >>> Dopamine; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ isotonic saline; ischemia; reperfusion injury; animal info (male, Lewis, 220-250 g).

P8278 Sakurai,S., Kojima,H., Uemura,M., Satoh,H., Fukui,H. Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats. WORLD JOURNAL OF GASTROENTEROLOGY 2006; 12(-13-):2095-2102. >>> Adrenomedullin, human; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle; comparison of IV injections vs. mp; cardiovascular; peptides; animal info (male, Sprague-Dawley, 150 grams); "Chronic infusion of AM (1.0 mg/h for 14 days) which keeps plasma human AM concentrations within the physiological limit reduced the vascular resistance and increased the blood flow in both of the systemic and splanchnic circulations." (p. 2100).

P8164 Barchiesi,F., Jackson,E.K., Fingerle,J., Gillespie,D.G., Odermatt,B., Dubey,R.K. 2-methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle. Circulation Research 2006; 99(-3-):266-274. >>> Estradiol, 2-methoxy-; IV; Rat; 7, 8, 14, days; Controls received mp w/ vehicle; no stress (see pg. 269); cardiovascular; toxicology; animal info (male, Wistar Kyoto, 350-400 grams); balloon carotid artery injury, "treatment with 2-ME was not associated with any toxic adverse effects." (p. 269); estradiol metabolite.

P8163 Boodhwani,M., Mieno,S., Voisine,P., Feng,J., Sodha,N., Li,J., Sellke,F.W. High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine. Journal of Thoracic and Cardiovascular Surgery 2006; 132(-6-):1299-1306. >>> Vascular endothelial growth factor 165, recomb. human; Heparin; Perivascular (circumflex coronary artery); Mini-pig; 2ML4; 4 weeks; Cardiovascular; peptides; ischemia (cardiac); animal info (male, female, yucatan, 20-30 kg, 23 weeks old).

P8148 Honore,P., Donnelly-Roberts,D., Namovic,M.T., Hsieh,G., Zhu,C.Z., Mikusa,J.P., Hernandez,G., Zhong,C.M., Gauvin,D.M., Chandran,P., Harris,R., Medrano,A.P., Carroll,W., Marsh,K., Sullivan,J.P., Faltynek,C.R., Jarvis,M.F. A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2- dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. Journal of Pharmacology and Experimental Therapeutics 2006; 319(-3-):1376-1385. >>> Vincristine sulfate; IV (jugular); Rat; 2002; 14 days; Animal info (male, Sprague-Dawley, 200-300g.); mp primed overnight; chemotherapy-induced neuropathic pain model.

P8102 de Celix,A.D.R., Chowen,J.A., Argente,J., Frago,L.M. Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. Journal of Neurochemistry 2006; 99(-3-):839-849. >>> Growth hormone releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 200-250g.).

P8089 Gebhard,C., Petroktistis,F., Zhang,H., Kammerer,D., Koehle,C., Klingel,K., Albinus,M., Gleiter,C.H., Osswald,H., Grenz,A. Role of renal nerves and salt intake on erythropoietin secretion in rats following carbon monoxide exposure. Journal of Pharmacology and Experimental Therapeutics 2006; 319(-1-):111-116. >>> Isoproterenol; neuropeptide Y, [Leu31, Pro34]-; neuropeptide Y1 receptor antagonist; IV (jugular); Rat; 1003D; 16 hours; Controls received mp w/ vehicle; half-life (p.115) "short" for isoproterenol; peptides; animal info (male, Sprague-Dawley, 250-320g.).

P8087 Lefebvre,F., Prefontaine,A., Calderone,A., Caron,A., Jasmin,J.F., Villeneuve,L., Dupuis,J. Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure. Clinical Science 2006; 111(-3-):217-224. >>> Angiotensin II; IV (jugular); Rat; 28 days; Controls received sham surgery; functionality of mp verified by plasma Ang II levels; cardiovascular; peptides; animal info (male, Wistar, coronary artery ligation MI, 350-380g).

P8064 Zhang,B., Hata,R., Zhu,P.X., Sato,K., Wen,T.C., Yang,L.H., Fujita,H., Mitsuda,N., Tanaka,J., Samukawa,K., Maeda,N., Sakanaka,M. Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression. Journal of Cerebral Blood Flow and Metabolism 2006; 26(-5-):708-721. >>> Ginsenoside Rb1; Saline, isotonic; IV (femoral); CSF/CNS; Rat; gerbil; 2001; 2004; 4 weeks; 1, 7 days; Controls received mp w/ vehicle; dose-response (fig. 2); cardiovascular; ischemia (cerebral); animal info (SHR-SP, 16-18 wk old, 250-300g. MCAO; male, Mongolian Gerbil, 70-80g., 12 wk old, MCAO).

P7985 Warne,J.P., Horneman,H.F., Wick,E.C., Bhargava,A., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores. Endocrinology 2006; 147(-11-):5443-5451. >>> Insulin, methylene blue; Saline; IV (jugular); Rat; 2002; ; Functionality of mp verified by dye infusion; replacement therapy (diabetic); no stress (see pg. 5444); good methods; peptides; animal info (male, Sprague-Dawley, 275 grams); diabetes; PE-60 fused to PE-5.

P7871 Ohtaki,H., Nakamachi,T., Dohi,K., Aizawa,Y., Takaki,A., Hodoyama,K., Yofu,S., Hashimoto,H., Shintani,N., Baba,A., Kopf,M., Iwakura,Y., Matsuda,K., Arimura,A., Shioda,S. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-19-):7488-7493. >>> Pituitary adenylate cyclase-activating polypeptide, 6-38; pituitary adenylate cyclase-activating polypeptide 38; pituitary adenylate cyclase-activating polypeptide; Saline; BSA; IV (jugular); Mice; 4, 8 hours; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (BALB/C, IL-6 -/-, +/-, wt); partial or total middle cerebral artery occlusion.

P7840 Choi,J., Credit,K., Henderson,K., Deverkadra,R., He,Z., Wiig,H., Vanpelt,H., Flessner,M.F. Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration. Clinical Cancer Research 2006; 12(-6-):1906-1912. >>> Immunoglobulin G, donkey anti-rabbit; radio-isotopes; Kreb's solution; bicarbonate; ringer's solution; sodium azide; 125I tracer; IV (jugular); Rat (nude); 2001; 5-7 days; Cancer (metastatic ovarian carcinoma); animal info (RNU-nude, athymic, 150-180g.).

P7837 Martini,A.C., Fernandez-Fernandez,R., Tovar,S., Navarro,V.M., Vigo,E., Vazquez,M.J., Davies,J.S., Thompson,N.M., Aguilar,E., Pinilla,L., Wells,T., Dieguez,C., Tena-Sempere,M. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 2006; 147(-5-):2374-2382. >>> Ghrelin, rat; ghrelin, des-octanoyl; L163, 255; Saline, sterile; heparin; BSA; IV (jugalar); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, 12 wk. old); L163, 255 is GHS-R1a-specific agonist.

P7746 Soucy,N.V., Riley,J.P., Templin,M.V., Geary,R., de Peyster,A., Levin,A.A. Maternal and fetal distribution of a phosphorothioate oligonucleotide in rats after intravenous infusion. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 2006; 77(-1-):22-28. >>> Oligodeoxynucleotide, phosphorothioate antisense; PBS; IV (jugular); Rat (pregnant); 2ML1; 7 days; Comparison of 3 hr. IV infusion vs. mp; no stress (see pg. 23); half-life (p. 25) 60 min.; antisense HPV; animal info (female, Sprague-Dawley, 318g, GD12-GD19); mp primed 6 hr. in sterile saline.

P7654 Timmapuri,S.J., Otterburn,D.M., Arafat,H., Schwartz,M.Z. Hepatocyte growth factor increases glucagon immunoreactivity in jejunal cells during intestinal adaptation. Journal of Pediatric Surgery 2006; 41(-1-):150-153. >>> Hepatocyte growth factor; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ saline; animal info (male, Sprague-Dawley, adult, 200-225 g); PE catheter used.

P8187 Welch,M.G., Welch-Horan,T.B., Anwar,M., Anwar,N., Ludwig,R.J., Ruggiero,D.A. Brain effects of chronic IBD in areas abnormal in autism and treatment by single neuropeptides secretin and oxytocin. Journal of Molecular Neuroscience 2005; 25(-3-):259-273. >>> Secretin; oxytocin; Saline; IV (femoral); Rat; 2002; 20 days; Controls received mp w/ vehicle; post op. care (Bacitracin); animal info (male, Sprague-Dawley, 250-450 grams); autism.

P8101 van der Wouden,E.A., Henning,R.H., Deelman,L.E., Roks,A.J.M., Boomsma,F., de Zeeuw,D. Does angiotensin (1-7) contribute to the antiproteinuric effect of ACE-inhibitors?. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 2005; 6(-2-):96-101. >>> Angiotensin (1-7); angiotensin (1-7), [D-Ala7]-; IV (jugular); Rat; 2002; 2 weeks; Controls received mp w/ saline; functionality of mp verified by plasma agent levels; animal info (male, Wistar, 275-300g., adriamycin-induced proteinuria); nephrology.

P7763 Soeki,T., Kishimoto,I., Okumura,H., Tokudome,T., Horio,T., Mori,K., Kangawa,K. C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction. Journal of the American College of Cardiology 2005; 45(-4-):608-616. >>> Natriuretic peptide, c-type synthetic; Glucose; IV (jugalar); Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley, 180-220g.); coronary artery ligation MI.

P7742 Hoeglinger,G.U., Lannuzel,A., Khondiker,M.E., Michel,P.P., Duyckaerts,C., Feger,J., Champy,P., Prigent,A., Medja,F., Lombes,A., Oertel,W.H., Ruberg,M., Hirsch,E.C. The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. Journal of Neurochemistry 2005; 95(-4-):930-939. >>> Rotenone; DMSO; PEG; IV (femoral); Rat; 2ML4; 28 days; Controls received mp w/ vehicle, or sham operated; no stress (see pg. 931); neurodegenerative (parkinson's syndrome, pick's disease); animal info (male, Lewis, 285-330g.; 50% DMSO/50% PEG).

P7711 Lindros,K.O., Jaervelaeinen,H.A. Chronic systemic endotoxin exposure: An animal model in experimental hepatic encephalopathy. METABOLIC BRAIN DISEASE 2005; 20(-4-):393-398. >>> Endotoxin, LPS; IV (jugular); Rat; 2ML4; 4 weeks; Functionality of mp verified by plasma endotoxin levels; tolerance; tubing contains pyrogen-free saline to delay agent delivery by 36 h..

P7653 Wiig,H., Gyenge,C.C., Tenstad,O. The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components. JOURNAL OF PHYSIOLOGY-LONDON 2005; 567(-2-):557-567. >>> Herceptin; immunoglobulin G, 1-; Radio-isotopes; 125I tracer; 131I tracer; IV (jugular); Rat; 2001; 5-7 days; Cancer (mammary); animal info (female, Sprague-Dawley, 208-255 g).

P7647 Barber,M.N., Gaspari,T.A., Kairuz,E.M., Dusting,G.J., Woods,R.L. Atrial natriuretic peptide preserves endothelial function during intimal hyperplasia. JOURNAL OF VASCULAR RESEARCH 2005; 42(-2-):101-110. >>> Atrial natriuretic peptide; C-type natriuretic peptide; Saline, sterile; IA (carotid); perivascular (arterial collar); Rabbit; 2001; 7 days; Cardiovascular; animal info (New Zealand white, 3-4 kg).

P7613 Frago,L.M., Paneda,C., Argente,J., Chowen,J.A. Growth hormone-releasing peptide-6 increases insulin-like growth factor-I mRNA levels and activates Akt in RCA-6 cells as a model of neuropeptide Y neurones. Journal of Neuroendocrinology 2005; 17(-11-):701-710. >>> Growth hormone-releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, wistar 200-250 g); ghrelin receptor agonist.

P7609 Wu,R.Q., Dong,W.F., Zhou,M., Cui,X.X., Simms,H.H., Wang,P. Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1. Cardiovascular Research 2005; 68(-2-):318-326. >>> Ghrelin, rat; PD 142893; Saline, normal; IV (jugular); Rat; 2001D; 15 hours; Controls received mp w/ vehicle or sham operated; functionality of mp verified by plasma levels; half-life (pg. 324) 11-17 min. in rat; cardiovascular; peptides; animal info (male, Sprague-Dawley 275-325 g); cecal ligation.

P7583 Chen,Y., Currie,R.W. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. INFLAMMATION RESEARCH 2005; 54(-8-):338-343. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (jugular); Rat; 2001; 2ML2; 3, 7 days; Controls received mp w/ vehicle or sham HS surgery; cardiovascular; peptides; animal info (male, Sprague-Dawley 280-310 g).

P7540 Babu,M., Purhonen,A.K., Bansiewicz,T., Maekelae,K., Walkowiak,J., Miettinen,P., Herzig,K.H. Effect of total colectomy and PYY infusion on food intake and body weight in rats. REGULATORY PEPTIDES 2005; 131(-1-3-):29-33. >>> Peptide YY (3-36); PBS; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; replacement therapy (proctocolectomy); no stress (see pg. 31-32) "no signs of stress... were found at any time during our studies"; peptides; post op. care (buprenorphine); animal info (male, Wistar 300-395 g); "we chose continuous infusion from subcutaneous implanted mini pumps to mimic physiological conditions and minimize stress caused by interperitoneal injections of the peptide." (p. 32).

P7490 Li,L.J., Joensson-Rylander,A.C., Abe,K., Zukowska,Z. Chronic stress induces rapid occlusion of angioplasty-injured rat carotid artery by activating neuropeptide Y and its Y1 receptors. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-10-):2075-2080. >>> H409/22; PEG 400; IV (jugular); Rat; 14 days; Controls received mp w/ vehicle; cardiovascular; animal info (male, Wistar, 350 g); Y1 receptor antagonist.

P7469 Gottmann,U., Notheisen,A., Brinkkoetter,P.T., Yard,B.A., Waldherr,R., Schnuelle,P., van der Woude,F.J., Braun,C. Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats. Transplantation 2005; 79(-10-):1344-1350. >>> Dopamine; Saline; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ vehicle; animal info (male, Lewis Fisher).

P7343 Tsuruda,T., Kato,J., Matsui,E., Hatakeyama,K., Masuyama,H., Imamura,T., Kitamura,K., Asada,Y., Eto,T. Adrenomedullin alleviates not only neointimal formation but also perivascular hyperplasia following arterial injury in rats. European Journal of Pharmacology 2005; 508(-1-3-):201-204. >>> Adrenomedullin; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels taken; cardiovascular.

P7330 Merklinger,S.L., Jones,P.L., Martinez,E.C., Rabinovitch,M. Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation 2005; 112(-3-):423-431. >>> Cilengitide; Saline; IV; Rat; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by agent plasma levels; cardiovascular.

P7298 Barrett,C.J., Guild,S.J., Ramchandra,R., Malpas,S.C. Baroreceptor denervation prevents sympathoinhibition during angiotensin II-induced hypertension. Hypertension 2005; 46(-1-):168-172. >>> Angiotensin II; IV (jugular); Rabbit; 2ML1; 1 week; Cardiovascular; peptides; radiotelemetry transmitter IA.

P7275 Garcia-Garcia,F., Ponce,S., Brown,R., Cussen,V., Krueger,J.M. Sleep disturbances in the rotenone animal model of Parkinson disease. Brain Research 2005; 1042(-2-):160-168. >>> Rotenone; DMSO; PEG; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/ vehicle, or saline; 50% DMSO; sleep; neurodegenerative (Parkinson's disease).

P7264 Boesen,E.I., Anderson,W.P., Kett,M.M. Role of endothelin in noradrenaline-induced hypertension in rats. Journal of Hypertension 2005; 23(-5-):987-993. >>> Noradrenalin; TAK-044; heparin; Saline, heparinized; ascorbic acid; saline; IV (vena cava); Rat; 2ML2; 24 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 2); pumps replaced at day 10; no stress (see pg. 989); stability verified by acute pressor activity after 14 days at 37 degrees celsius in mp; cardiovascular; multiple pumps per animal (2); 10 IU/ml of heparin.

P7260 Milusheva,E., Baranyi,M., Kittel,A., Sperlagh,B., Vizi,E.S. Increased sensitivity of striatal dopamine release to H2O2 upon chronic rotenone treatment. Free Radical Biology and Medicine 2005; 39(-1-):133-142. >>> Rotenone; DMSO; PEG 300; IV (jugular); Rat; 2, 4 weeks; Controls received mp w/ vehicle, or sham operation; 50% DMSO; mp primed overnight in 37 degrees celsius saline; mitochondrial complex I inhibitor; neurodegenerative (parkinson's disease).

P7183 Migneault,A., Sauvageau,S., Villeneuve,L., Thorin,E., Fournier,A., Leblanc,N., Dupuis,J. Chronically elevated endothelin levels reduce pulmonary vascular reactivity to nitric oxide. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2005; 171(-5-):506-513. >>> Endothelin-1; Water; IV (jugular); Rat; 7, 20 days; Controls received sham surgery; functionality of mp verified by plasma E7-1 levels; stability verfied by 7 and 28 day incubation at 37 degrees celsius and HPLC; cardiovascular; peptides.

P7138 Bahat-Stroomza,M., Gilgun-Sherki,Y., Offen,D., Panet,H., Saada,A., Krool-Galron,N., Barzilai,A., Atlas,D., Melamed,E. A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease. European Journal of Neuroscience 2005; 21(-3-):637-646. >>> Rotenone; DMSO; PEG; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/ vehicle; enzyme inhibitor (NADH-ubiquinone oxidoreductase); mp primed in 37 degrees celsius saline for at least 4 hours; 50% DMSO neurodegenerative (Parkinson's disease).

P7135 Benlloch,M., Ortega,A., Ferrer,P., Segarra,R., Obrador,E., Asensi,M., Carretero,J., Estrela,J.M. Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity. Journal of Biological Chemistry 2005; 280(-8-):6950-6959. >>> Acivicin; verapamil; IV; Mice; 2001D; 7 hours; Controls received mp w/ physiological saline; cancer (melanoma).

P7125 Lynch,JJ III, Wade,C.L., Mikusa,J.P., Decker,M.W., Honore,P. ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. European Journal of Pharmacology 2005; 509(-1-):43-48. >>> Vincristine sulfate; Saline, physiological; IV (external jugular); Rat; 2002; 1-3 weeks; Cancer; mp primed overnight.

P7063 Langeveld,B., van Gilst,W.H., Tio,R.A., Zijlstra,F., Roks,A.J.M. Angiotensin-(1-7) attenuates neointimal formation after stent implantation in the rat. Hypertension 2005; 45(-1-):138-141. >>> Angiotensin (1-7); IV (jugular); Rat; 2004; 4 weeks; Controls received mp w/ saline; cardiovascular; peptides.

P7047 Biswas,P., Roy,A., Gong,R.J., Yango,A., Tolbert,E., Centracchio,J., Dworkin,L.D. Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate. American Journal of Physiology-Renal Physiology 2005; 288(-1-):F8-F15. >>> Hepatocyte growth factor; Saline; IV (jugular); Rat; 1 week; Controls received mp w/ vehicle; functionality of mp verified by plasma and urine HGF levels; comparison of acute IV infusions vs. mp; no stress (see pg. F12); post op. care (atipamezole).

P6950 Chen,W.H., Langer,R.M., Janczewska,S., Furian,L., Geary,R., Qu,X.M., Wang,M., Verani,R., Condon,T., Stecker,K., Bennett,C.F., Stepkowski,S.M. Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation 2005; 79(-4-):401-408. >>> Oligonucleotide, antisense; Saline; IV; Rat; 7 days; Comparison of gavage and IV injections vs. mp; antisense (phosphorothioate/phosphodiester); transplantation; 14 d pump used; immunology.

P6894 Tejeda,M, Gaal,D., Csuka,O., Keri,G.Y. Growth Inhibitory Effect of the Somatostatin Structural Derivative (TT-232) on Leukemia Models. Anticancer Research 2005; 25(--):325-330. >>> TT-232; Acetic acid; sodium acetate; water; mannitol; IV; SC; Mice; 2002; 14, 28 days; Dose-response (p. 328, fig 1); comparison of IP/SC injections vs. SC/IV mp; pumps replaced at day 14 for 28 day group; stability verified, 37 degrees Celsius for over 3 weeks; cancer (leukemia); TT-232 is a novel somatostatin analog; "The IV infusion for 28 days resulted in 82% growth inhibition." (p. 328); "The infusion of TT-232 by ALZET osmotic minipump resulted in 70-80% tumor growth inhibition and 20% tumor free survival." (p. 329); "…serial injections represent significant stress to the animals…" "To reduce and eliminate the above mentioned problem [stress] we used an ALZET osmotic minipump…" "Infusion from inserted ALZET minipumps maintains a constant drug level, resulting in a well defined, consistent pattern of drug exposure throughout the period of drug administration." "These studies suggest that TT-232 is a potent inhibitor of leukemia tumor in vitro and in vivo and suggest infusion treatment as a beneficial application in clinical practice." (p. 330); oligopeptide; enzyme inhibitor (tyrosine kinase); animal info (CBA/ca, immunosuppressed, female).

P7066 Lynch,JJ III, Wade,C.L., Zhong,C.M.M., Mikusa,J.P., Honore,P. Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model. Pain 2004; 110(-1-2-):56-63. >>> Vincristine sulfate; Saline, physiological; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle; no stress (see pg. 58); cancer; mp primed overnight.

P7052 Alley,M.C., Hollingshead,M.G., Pacula-Cox,C.M., Wand,W.R., Hartley,J.A., Howard,P.W., Gregson,S.J., Thurston,D.E., Sausville,E.A. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 2: Efficacy evaluations. Cancer Research 2004; 64(-18-):6700-6706. >>> SJG-136; DMSO; PEG; IV (jugular); Mice (nude); 2001; 5 days; Controls received mp w/ vehicle; comparison of IV injections vs. mp; no stress (see pg. 6706); cancer (melanoma); agent also known as NSC 694501; 50% DMSO; "It is noteworthy that 5-day continuous infusions are highly effective in the LOX IMVI tumor model...continuous infusions were highly active and the lower peak plasma concentrations afforded by them may render infusion a useful mode for SJG-136 delivery in man." (pg. 6704-5).

P7046 Bilodeau,M., Tousignant,J., Ethier,C., Rocheleau,B., Raymond,V.A., Lapointe,R. Anti-apoptotic effect of insulin on normal hepatocytes in vitro and in vivo. Apoptosis 2004; 9(-5-):609-617. >>> Insulin; HEPES buffer; IV (portal); Rat; 2001; 2,7 days; Controls received mp w/ vehicle; functionality of mp verified by degree of phosphorylation of insulin receptor; replacement therapy (liver atrophy); dose-response.

P7010 Yao,L., Kobori,H., Rahman,M., Seth,D.M., Shokoji,T., Fan,Y.Y., Zhang,G.X., Kimura,S., Abe,Y., Nishiyama,A. Olmesartan improves endothelin-induced hypertension and oxidative stress in rats. HYPERTENSION RESEARCH 2004; 27(-7-):493-500. >>> Endothelin-1; Saline; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides.

P6995 Wang,Y.P., Wang,D.H. Prevention of endothelin-1-induced increases in blood pressure: role of endogenous CGRP. American Journal of Physiology-Heart and Circulatory Physiology 2004; 287(-4-):H1868-H1874. >>> Endothelin-1; Saline, normal; IV (external jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by confirming mp was empty and correct catheter position; cardiovascular; peptides.

P6945 Kimura,S., Zhang,G.X., Nagai,Y., Miyata,K., Nishiyama,A., Shokoji,T., Yao,L., Fan,Y.Y., Rahman,M., Fujisawa,Y., Miyatake,A., Abe,Y. Time-dependent transition of tempol-sensitive reduction of blood pressure in angiotension II-induced hypertension. Journal of Hypertension 2004; 22(-11-):2161-2168. >>> Angiotensin II; Saline; IV; Rat; ; Blood pressure taken; cardiovascular; peptides.

P6927 Borgal,L., MacLeod,M., Hong,M., Lewington,M., Sadi,D., Mendez,I. Effect of local liposomal tacrolimus on cell survival and behavioural recovery following double co-grafts of VM and GDNF-C17.2 cells in the 6-OHDA rat model of Parkinson's disease. Experimental Neurology 2004; 187(-1-):225-225. >>> Rotenone; IV (jugular); Rat; 2 weeks; Neurodegenerative (Parkinson's disease).

P6925 van Brakel,T.J., Hermans,J.J.R., Janssen,B.J., van Essen,H., Botterhuis,N., Smits,J.F.M., Maessen,J.G. Intrapericardial delivery enhances cardiac effects of sotalol and atenolol. Journal of Cardiovascular Pharmacology 2004; 44(-1-):50-56. >>> Sotalol; atenolol; Saline; IV (jugular); intrapericardial; Rat; 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; 2 day recovery period prior to attaching pumps to catheters.

P6854 Ling,Z.D., Chang,Q.A., Tong,C.W., Leurgans,S.E., Lipton,J.W., Carvey,P.M. Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally. Experimental Neurology 2004; 190(-2-):373-383. >>> Rotenone; DMSO; PEG; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; stress/adverse reaction: (see pg. 376) One agent and one veh. animal became sick immediately after surgery, 2 more became sick at 10 days, the remaining 24 animals survived the protocol with no adverse effects; toxicology; 50% DMSO; animals received prenatal LPS.

P6831 Mphahlele,N.R., Fuller,A., Roth,J., Kamerman,P.R. Body temperature, behavior, and plasma cortisol changes induced by chronic infusion of Staphylococcus aureus in goats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2004; 287(-4-):R863-R869. >>> Bacteria, staphylococcus aureus; IV (jugular); Goat; 2ML1; ; Controls received mp w/ sterile saline; functionality of mp verified by examining contents of internal reservoir; comparison of IV injections vs. mp; no stress (see pg. R864); post op. care (enrofloxacin); catheter filled with heparinized saline (100 units/ml); to delay infusion of pump contents until 24 hours after mp implantation; "no signs of secondary infection or pathology...were found." (p. R864)..

P6783 Tsuneyoshi,H., Nishina,T., Nomoto,T., Kanemitsu,H., Kawakami,R., Unimonh,O., Nishimura,K., Komeda,M. Atrial natriuretic peptide helps prevent late remodeling after left ventricular aneurysm repair. Circulation 2004; 110(-11-):II174-II179. >>> Carperitide; Water, distilled; IV (jugular, left); Rat; 2ML4; 4 weeks; Controls received mp w/ normal saline, functionality of mp verified by plasma hANP levels; carperitide is recomb. alpha-human atrial natriuretic peptide; "We (the authors) think that long-term infusion of low-dose ANP may be a reasonable and effective therapy to prevent LV remodeling after LVR." (p. II 178).

P6782 Zhou,M., Simms,H.H., Wang,P. Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis. Annals of Surgery 2004; 240(-2-):321-330. >>> Adrenomedullin, synthetic rat; Saline, sterile; IV (jugular); Rat; 2001D; 23 hours; Controls received mp w/ vehicle; cardiovascular; peptides; polymicrobial sepsis induced by cecal ligation and puncture.

P6756 Sasaki,T., Kasuya,H., Onda,H., Sasahara,A., Goto,S., Hori,T., Inoue,I. Role of p38 mitogen-activated protein kinase on cerebral vasospasm after subarachnoid hemorrhage. Stroke 2004; 35(-6-):1466-1470. >>> FR167653; IV (jugular); Dog; 7 days; Controls received mp w/ physiological saline; functionality of mp verified by serum FR167653 levels; enzyme inhibitor (p38MAPKinase); cardiovascular; ischemia (cerebral).

P6731 Schermuly,R.T., Kreisselmeier,K.P., Ghofrani,H.A., Samidurai,A., Pullamsetti,S., Weissmann,N., Schudt,C., Ermert,L., Seeger,W., Grimminger,F. Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension. Circulation Research 2004; 94(-8-):1101-1108. >>> Tolafentrine; iloprost; Saline; IV (jugular); Rat; 2ML2; 14 days; Dose-response (p.1103); PE-50 used; PDE 3.4 inhibitor.

P6694 Saadi,S., Takahashi,T., Holzknecht,R.A., Platt,J.L. Pathways to acute humoral rejection. American Journal of Pathology 2004; 164(-3-):1073-1080. >>> Interleukin-1, receptor antagonist; IV (vena cava); Rat; guinea-pig; ; PE-50 tubing used; agent delivered using a 2ML model pump.

P6670 Luo,B., Liu,L.C., Tang,L.P., Zhang,J.L., Ling,Y.Q., Fallon,M.B. ET-1 and TNF-alpha in HPS: analysis in prehepatic portal hypertension and biliary and nonbiliary cirrhosis in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 2004; 286(-2-):G294-G303. >>> Endothelin-1; Saline; IV (femoral); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; ET-1 plasma levels taken.

P6624 Ling,Y.Q., Zhang,J.L., Luo,B., Song,D.S., Liu,L.C., Tang,L.P., Stockard,C.R., Grizzle,W.E., Ku,D.D., Fallon,M.B. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Hepatology 2004; 39(-6-):1593-1602. >>> BQ123; BQ788; Saline; IV (femoral); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; the peptides are selective endothelin A and B receptor antagonists.

P6525 Bai,S., Stepkowski,S.M., Kahan,B.D., Brunner,L.J. Metabolic interaction between cyclosporine and sirolimus. Transplantation 2004; 77(-10-):1507-1512. >>> Cyclosporin; sirolimus; Sandimmune IV solution; dimethylacetamide, N-N-; tween 80; PEG 400; IV (femoral); Rat; 2002; 14 days; Controls received mp w/ vehicle; multiple pumps per animal (2); CSA was purchased as sandimmune IV solution (cremophor or castor oil and 33% ethanol); SRL was dissolved in Tween 80 (10%), PEG 400 (70%), and dimethyl acetamide, N-N- (20%); Immunology.

P6521 Llinas,M.T., Alexander,B.T., Capparelli,M.F., Carroll,M.A., Granger,J.P. Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats. Hypertension 2004; 43(-3-):623-628. >>> Aminobenzotriazole, 1-; Saline; IV (jugular); Rat (pregnant); 2ML1; 7 days; Controls received mp w/ vehicle; no stress (see pg.624); enzyme inhibitor (cytochrome - p450); cardiovascular; antihypertensive; ABT.

P6507 Parkington,H.C., Dodd,J., Luff,S.E., Worthy,K., Coleman,H.A., Tare,M., Anderson,W.P., Edgley,A.J. Selective increase in renal arcuate innervation density and neurogenic constriction in chronic angiotensin II-Infused rats. Hypertension 2004; 43(-3-):643-648. >>> Angiotensin II; Soldium chloride; heparin; IV (vena cava); Rat; 2ML4; 21 days; Controls received mp w/ vehicle; no stress (see pg.644); cardiovascular; peptides; 10 IU/ml of heparin.

P6492 Chen,Y., Ross,B.M., Currie,R.W. Heat shock treatment protects against angiotensin II-induced hypertension and inflammation in aorta. CELL STRESS&CHAPERONES 2004; 9(-1-):99-107. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (vena cava); Rat; 2001; 2002; 2ML2; 1,3,5,7,11,14 days; Controls received empty mp for 7 days; functionality of mp verified by SBP; cardiovascular; peptides.

P6474 Wahlgren,C.M., Frebelius,S., Swedenborg,J. Inhibition of neointimal hyperplasia by a specific thrombin inhibitor. SCANDINAVIAN CARDIOVASCULAR JOURNAL 2004; 38(-1-):16-21. >>> Inogatran; IV (jugular); Rat; 2ML1; 1 week; Controls received no treatment; functionality of mp verified by drug plasma levels; comparison of 3 hr. infusion vs. injections vs. mp; enzyme inhibitor (thrombin); cardiovascular (restenosis); "Inogatran given w/ a continuous osmotic pump for 1 week had the lowest neointima/media ratio (greatest desired effect), which was significantly lower than the control group and also significantly lower than other treatments." (P. 18).

P6454 Daniel,C., Wiede,J., Krutzsch,H.C., Ribeiro,S.M.F., Roberts,D.D., Murphy-Ullrich,J.E., Hugo,C. Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo. Kidney International 2004; 65(-2-):459-468. >>> Thrombospondin-1; IV; Rat; 2ML1; 7 days; Peptides.

P6436 Porro,C.A., Cavazzuti,M., Giuliani,D., Vellani,V., Lui,F., Baraldi,P. Effects of ketamine anesthesia on central nociceptive processing in the rat: A 2-deoxyglucose study. Neuroscience 2004; 125(-2-):485-494. >>> Heparin; Saline; IA (carotid); IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; post op. care (wounds treated with local anesthetics, lidocaine cream); PE-50 tubing was filled with rat serum and heparin and plugged with nylon fishing line until the pumps were attached; pumps were used only as a means of keeping vessel catheters patent..

P6413 Arthur,L.G., Schwartz,M.Z., Kuenzler,K.A., Birbe,R. Hepatocyte growth factor treatment ameliorates diarrhea and bowel inflammation in a rat model of inflammatory bowel disease. Journal of Pediatric Surgery 2004; 39(-2-):139-143. >>> Hepatocyte growth factor; Saline; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle.

P6398 Fujita,M., Ishihara,M., Ono,K., Matsumura,K., Saito,Y., Yura,H., Morimoto,Y., Shimizu,M., Takase,B., Ozaki,S., Kikuchi,M., Maehara,T. Inhibition of neointimal proliferation in balloon-injured arteries using non-anticoagulant heparin-carrying polystyrene. Journal of Cardiovascular Pharmacology 2004; 43(-1-):31-38. >>> Heparin, periodate-oxidized; heparin, periodate-oxidized alkaline-degraded low molecular weight; NAC-HCPS; IV (jugular); Rat; 2ML1; 7 days; Cardiovascular; NAC-HCPS is non-anticoagulant heparin-carrying polystyrene.

P6391 Dworkin,L.D., Gong,R.J., Tolbert,E., Centracchio,J., Yano,N., Zanabli,A.R., Esparza,A., Rifai,A. Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury. Kidney International 2004; 65(-2-):409-419. >>> Hepatocyte growth factor; Saline; IV (jugular); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; PE-50 used.

P6386 Kohno,M., Ishizaka,A., Sawafuji,M., Koh,H., Hirayama,Y., Ikeda,E., Shiomi,T., Ohashi,A., Okada,Y., Kobayashi,K. Hyperoxia-induced emphysematous changes in subacute phase of endotoxin-induced lung injury in rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2004; 287(-1-):L184-L190. >>> Endotoxin, E. coli; Saline; IV (jugular); Rat; 2002; 10 days; 24 hour recovery period achieved by filling catheter with saline.

P6381 Dilley,R.J., Rizkalla,B., Bertram,J.F. Cardiovascular hypertrophy in one-kidney, one-clip renal hypertension is resistant to heparin. Journal of Hypertension 2004; 22(-4-):767-774. >>> Heparin; uridine, bromodeoxy-; Saline; IV; Rat; 2 weeks; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; pump model not listed.

P6287 Champy,P., Hoeglinger,G.U., Feger,J., Gleye,C., Hocquemiller,R., Laurens,A., Guerineau,V., Laprevote,O., Medja,F., Lombes,A., Michel,P.P., Lannuzel,A., Hirsch,E.C., Ruberg,M. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. Journal of Neurochemistry 2004; 88(-1-):63-69. >>> Annonacin; DMSO; PEG 400; IV (femoral); Rat; 2ML4; 28 days; Controls received mp w/ vehicle; annonacin is a lipophilic inhibitor of mitochondrial complex I; Parkinson's disease; behavorial study; 50/50 DMSO&PEG; multiple doses used; neurotoxin; plant extract; neurodegenerative (Parkinson's disease).

P6281 Fleming,S.M., Zhu,C.N., Fernagut,P.O., Mehta,A., DiCarlo,C.D., Seaman,R.L., Chesselet,M.F. Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone. Experimental Neurology 2004; 187(-2-):418-429. >>> Rotenone; DMSO; PEG; SC; IV (jugular); Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; comparison of sc infusion vs. iv infusion; parkinson's disease; pump was prefilled 1-2 days before implantation; 50% DMSO/ 50% PEG; teflon tubing used as a flow moderator; behavioral study; neurodegenerative (Parkinson's disease).

R0226 Carvey,P.M., Chang,Q., Lipton,J.W., Ling,Z.D. Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: A potential, new model of Parkinson's disease. FRONTIERS IN BIOSCIENCE 2003; 8(--):S826-S837. >>> Rotenone; IV (jugular); Rat; 14 days; Controls received mp w/ HBSS; stress/adverse reaction (see pg. 832) "high mortality was seen in the rotenone animals exposed to LPS prenatally."; ALZET pumps mentioned on p. 832; neurodegenerative (Parkinson's disease).

P7207 Ogawa,A., Morimoto,T., Hu,J.W., Tsuboi,Y., Tashiro,A., Noguchi,K., Nakagawa,H., Iwata,K. Hard-food mastication suppresses complete Freund's adjuvant-induced nociception. Neuroscience 2003; 120(-4-):1081-1092. >>> Naloxone; IV (jugular); Rat; 3, 6 days; Controls received mp w/ saline; functionality of mp verified by measuring residual volume.

P6600 Paneda,C., Arroba,A.I., Frago,L.M., Holm,A.M., Romer,J., Argente,J., Chowen,J.A. Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats. NeuroReport 2003; 14(-12-):1633-1635. >>> Growth hormone-rel. peptide-6; IV (external jugular); Rat; 2ML1; 7 days; Controls received mp w/ saline; peptides; GHRP-6 is a synthetic ligand for the ghrelin receptor.

P6414 Arthur,L.G., Kuenzler,K.A., Schwartz,M.Z. Hepatocyte growth factor ameliorates inflammatory bowel disease in a rat model. JOURNAL OF GASTROINTESTINAL SURGERY 2003; 7(-8-):1062-1067. >>> Hepatocyte growth factor; Tris buffer; IV (jugular); Rat; 2002; 14 days; Peptides; one group of rats received HGF intravenously (jugular) and another received HGF intravenously via the terminal ileal.

P6408 Van Landeghem,F.K.H., Schreiber,S., Unterberg,A.W., Von Deimling,A., Stover,J.F. Differential concentration-dependent effects of prolonged norepinephrine infusion on intraparenchymal hemorrhage and cortical contusion in brain-injured rats. Journal of Neurotrauma 2003; 20(-12-):1327-1337. >>> Norepinephrine; Saline; IV; Rat; 2001; 44 hours; Controls received mp w/ vehicle; blood pressure taken; dose-response (p. 1329); brain injury.

P6150 Marshall,J.W.B., Cummings,R.M., Bowes,L.J., Ridley,R.M., Green,A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion. Stroke 2003; 34(-9-):2228-2233. >>> NXY-059; Saline; IV; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; NXY-059 plasma levels taken; pumps replaced every 24 hours; post op. care (flunixin meglumine); behavior study; neuroprotective; ischemia (cerebral).

P6131 Tejeda,M., Gaal,D., Csuka,O., Ullrich,A., Schwab,R., Pap,A., Horvath,A., Keri,G. The antitumor effect of the somatostatin analogue TT-232 depends on th e treatment regimen. Cancer Detection and Prevention 2003; 27(-2-):155-162. >>> TT-232; Acetic acid; sodium acetate; mannitol; SC; IV (jugular); Mice; 2001; 2002; 1,2,4 weeks; Comparison of SC + IV injections vs. mp; 2002 pumps replaced after 14 days; cancer (sarcoma colon, breast lymphoma); somatostatin analog; PE-10 tubing used for IV group; "The infusion treatment with ALZET Osmotic Pumps proved to be superior to both twice daily injections or intravenous injections." (p. 155).

P6099 Roy,S., Balasubramanian,S., Wang,J.H., Chandrashekhar,Y., Charboneau,R., Barke,R. Morphine inhibits VEGF expression in myocardial ischemia. Surgery 2003; 134(-2-):336-344. >>> Morphine; Saline; IV (jugular); Rat; 2001; 1 week; Controls received mp w/ vehicle; ischemia (cardiac).

P6091 Pelaez,L.I., Manriquez,M.C., Nath,K.A., Romero,J.C., Juncos,L.A. Low-dose angiotensin II enhances pressor responses without causing sustained hypertension. Hypertension 2003; 42(-4-):798-801. >>> Angiotensin II; IV (jugular); Rat; 2001; 2ML2; 12 days; Functionality of mp verified by angiotensin II plasma levels taken; cardiovascular; peptides; telemetry devices implanted.

P6079 Li,P., Li,J., Feng,X., Li,Z., Hou,R., Han,C., Zhang,Y. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. CELLULAR AND MOLECULAR LIFE SCIENCES 2003; 60(-10-):2200-2209. >>> Norepinephrine; Ascorbic acid; IV (jugular); Rat; 2002; 7 days; Functionality of mp verified by liquid chromatography; cardiovascular.

P6059 Sedeek,M.H., Llinas,M.T., Drummond,H., Fortepiani,L., Abram,S.R., Alexander,B.T., Reckelhoff,J.F., Granger,J.P. Role of reactive oxygen species in endothelin-induced hypertension. Hypertension 2003; 42(-4-):806-810. >>> Endothelin-1; tempol; IV (jugular); Rat; 2002; 9 days; Peptides.

P6058 DeLeve,L.D., Wang,X.D., Kanel,G.C., Ito,Y., Bethea,N.W., McCuskey,M.K., Tokes,Z.A., Tsai,J., McCuskey,R.S. Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology 2003; 38(-4-):900-908. >>> V-PYRRO/NO; IV (inferior mesenteric); Rat; 2ML1; 4 days; N-PYRRO/NO is a liver-selective NO donor prodrug. "5 mg/ml, is the maximum concentration that can be used to avoid solubility problems." p. 901; experiments that required a higher dose of V-PYRRO/NO, multiple pumps per animal used (2) to deliver the drugs; with the second pump infusing via a cannula inserted into a tributary of the splenic vein.

P6051 Mardon,K., Montague,O., Elbaz,N., Malek,Z., Syrota,A., Dubois-Rande,J.L., Meignan,M., Merlet,P. Uptake-1 carrier downregulates in parallel with theβ-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: Implications for cardiac neuroimaging in human cardiomyopathies. Journal of Nuclear Medicine 2003; 44(-9-):1459-1466. >>> Norepinephrine; Saline; IV (jugular); Rat; 2001; 5 days; Controls received mp w/ vehicle; cardiovascular; silastic catheter used.

P6046 Michetti,C., Coimbra,R., Hoyt,D.B., Loomis,W., Junger,W., Wolf,P. Pentoxifylline reduces acute lung injury in chronic endotoxemia. Journal of Surgical Research 2003; 115(-1-):92-99. >>> Pentoxifylline; endotoxin, e. coli; Saline; IV (jugular); Rat; 4,48 hours; Controls received mp w/ vehicle; enzyme inhibitor (phospodiesterase); silastic catheter used; pump model not stated.

P6035 Ameredes,B.T., Otterbein,L.E., Kohut,L.K., Gligonic,A.L., Calhoun,W.J., Choi,A.M.K. Low-dose carbon monoxide reduces airway hyperresponsiveness in mice. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2003; 285(-6-):L1270-L1276. >>> Rp-8-BrcGMP; Saline; IV (jugular); Mice; 10 days; Rp-8-BrcGMP is an inhibitor of cGMP production; pump model not listed.

P6010 Liu,S.Q., Tieche,C., Tang,D.L., Alkema,P. Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-β receptor and Src. American Journal of Physiology-Heart and Circulatory Physiology 2003; 285(-3-):H1081-H1090. >>> AG-1296; PP1; IV (vena cava); Rat; 2001D; 10 days; AG-1296 and PP1 are selective PDGF-B receptor tyrosine kinase and SRC inhibitors; enzyme inhibitor (tyrosine kinase).

P5979 DeLeve,L.D., Wang,X.D., Tsai,J., Kanel,G., Strasberg,S., Tokes,Z.A. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology 2003; 125(-3-):882-890. >>> BPP; IV (inferior mesenteric); Rat; 2ML1; ; Enzyme inhibitor (MMP-2/MMP-9); BPP, a MMP-2/MMP-9 inhibitor is also known as 2-[(4-biphenyl sulfanyl)-amino]-3-phenyl-propionic acid.

P5974 Calvillo,L., Masson,S., Salio,M., Pollicino,L., De Angelis,N., Fiordaliso,F., Bai,A., Ghezzi,P., Santangelo,F., Latini,R. In vivo cardioprotection by N-acetylcysteine and isosorbide 5-mononitrate in a rat model of ischemia-reperfusion. Cardiovascular Drugs and Therapy 2003; 17(-3-):199-208. >>> Acetylcysteine, N-; SC; IV (jugular); Rat; 2ML1; 7 days; 24 hours; Ischemia (cardiac).

P5961 Edgley,A.J., Kett,M.M., Anderson,W.P. Evidence for renal vascular remodeling in angiotensin II-induced hyper tension. Journal of Hypertension 2003; 21(-7-):1401-1406. >>> Angiotensin II; Saline; heparin; IV (vena cava); Rat; 2ML4; 10 days; controls received mp w/ vehicle; post op. care (sc, buprenorphine); pumps implanted IP; catheter targeted the vena cava via the lumbar vein; 10 IU/ml of heparin.

P5949 Szende,B., Keri,G. TT-232: a somatostatin structural derivative as a potent antitumor drug candidate. Anti-cancer Drugs 2003; 14(-8-):585-588. >>> TT-232; SC; IV; Mice (SCID); 2002; 14 days; Comparison of SC injections vs. mp; cancer (sarcoma, lymphoid, colon, breast); peptides; TT-232 is a somatostatin analog; "the infusion treatment using implanted ALZET-type osmotic mini-pumps proved to be superior to both S.C. and I.V. infusion applied twice a day for 2 weeks." (p. 586).

P5897 Hoglinger,G.U., Feger,J., Prigent,A., Michel,P.P., Parain,K., Champy,P., Ruberg,M., Oertel,W.H., Hirsch,E.C. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. Journal of Neurochemistry 2003; 84(-3-):491-502. >>> Rotenone; DMSO; PEG 400; IV (femoral); Rat; 2ML4; 28 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; neurodegenerative (Parkinson's disease); behavorial study; 50% DMSO and 50% PEG 400 used in vehicle.

P5892 Jin,H.K., Yang,R.H., Li,W., Ogasawara,A.K., Schwall,R., Eberhard,D.A., Zheng,Z., Kahn,D., Paoni,N.F. Early treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction. Journal of Pharmacology and Experimental Therapeutics 2003; 304(-2-):654-660. >>> Hepatocyte growth factor; Saline; heparin; IV (jugular); Rat; 2001; 6 days; Controls received mp w/ vehicle; functionality of mp verified by blood pressure taken&plasma levels taken; cardiovascular; peptides; recomb human HGF used; 50 U/ml of heparin.

P5882 Teeters,J.C., Erami,C., Zhang,H., Faber,J.E. Systemic alpha(1A)-adrenoceptor antagonist inhibits neointimal growth after balloon injury of rat carotid artery. American Journal of Physiology-Heart and Circulatory Physiology 2003; 284(-1-):H385-H392. >>> KMD-3213; Ethanol; water; IV (femoral); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (p. H387, H390); plasma levels taken; KMD-3213 (Adrenoceptor antagonist) was dissolved in 50% ethanol&water, fenestrated catheter filled with heparinized saline; analgesia used.

P5876 Wiig,H, Reed,R.K., Tenstad,O  Am J Physiol Heart Circ Physiol 2003; 278(-5-):H1627-H1639. >>> Albumin, rat serum; Radio-isotopes; 125I tracer; IV (jugular); Rat; 2001; 4-7 days; Functionality of mp verified by blood samples taken; good methods p. H1629; interstitial fluid volumes.

P5862 Velkoska,E., Morris,M.J., Burns,P., Weisinger,R.S. Leptin reduces food intake but does not alter weight regain following food deprivation in the rat. International Journal of Obesity 2003; 27(-1-):48-54. >>> Leptin, murine; Saline; heparin; IV (femoral); Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by leptin plasma levels; saline pumps replaced after 14 days w/ leptin pumps; peptides; rats received IV saline at 5 ul/hr for the first two weeks; heparin dose 50 U/ml.

P5794 Qing,X., Wimalawansa,S.J., Keith,I.M. Specific N-terminal CGRP fragments mitigate chronic hypoxic pulmonary hypertension in rats. REGULATORY PEPTIDES 2003; 110(-2-):93-99. >>> Calcitonin gene-related peptide (1-8), alpha-Rat; Calcitonin gene-related peptide (1-13), alpha-Rat; Calcitonin gene-related peptide (1-14), alpha-Rat; Saline; Bacitracin; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle; antihypertensive; peptides; N-terminal rat alpha-CGRP (calcitonin gene-related peptide) was dissolved in saline with 1 mg/ml of Bacitracin&infused in either a 2002 (lower doses) or a 2ML2 (higher doses).

P5781 Negrini,D., Tenstad,O., Wiig,H. Interstitial exclusion of albumin in rabbit lung measured with the continuous infusion method in combination with the wick technique. MICROCIRCULATION 2003; 10(-2-):153-165. >>> Albumin, rabbit serum;; PBS; radio-isotopes; 125I-Tracer; IV (jugular); Rabbit; 2001; 5-7 days.

P5771 Smith,L., Payne,J.A., Sedeek,M.H., Granger,J.P., Khalil,R.A. Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet. Hypertension 2003; 41(-3-):787-793. >>> Endothelin-1; IV; Rat; 5 days; Controls received mp w/ saline.

P5728 Briest,W., Holzl,A., Rassler,B., Deten,A., Baba,H.A., Zimmer,H.G. Significance of matrix metalloproteinases in norepinephrine-induced remodelling of rat hearts. Cardiovascular Research 2003; 57(-2-):379-387. >>> Norepinephrine; Saline; Ascorbic Acid; IV (jugular); Rat; 14 days; Controls received mp w/ vehicle; cardiovascular; Norepinephrine is also called Noradrenalin; ascorbic acid added to vehicle solution to prevent oxidation.

P5690 Luo,B., Liu,L.C., Tang,L.P., Zhang,J.L., Stockard,C.R., Grizzle,W.E., Fallon,M.B. Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome. Journal of Hepatology 2003; 38(-5-):556-563. >>> Endothelin-1; IV (femoral); Rat; 2002; 2 weeks; Funcionality of mp verified by pump assessment; 2-week stability verified by previous studies by other groups; ET-1 plasma levels measured.

P5685 Cormier,A., Morin,C., Zini,R., Tillement,J.P., Lagrue,G. Nicotine protects rat brain mitochondria against experimental injuries. Neuropharmacology 2003; 44(-5-):642-652. >>> Nicotine bitartrate; rotenone; Saline; DMSO; PEG; SC; IV (jugular); Rat; 2001; 2002; 2ML2; 7, 14 days; Controls received mp w/ vehicle; dose-response (fig 2; p. 647); neurodegenerative (Parkinson's disease); 50% DMSO: 50% PEG vehicle for rotenone; multiple pumps per animal (2); rotenone dissolved in 50/50 DMSO/PEG and delivered via 2ML2 pumps; nicotine dissolved in saline and delivered via 2001 and 2002 pumps..

P5677 Nahi,F., Arbogast,L.A. Prolactin modulates hypothalamic preproenkephalin, but not proopiomelanocortin, gene expression during lactation. Endocrine 2003; 20(-1-2-):115-122. >>> Prolactin, ovine; Sodium bicarbonate; heparin; NaCl; IV (jugular); Rat; ; Controls received mp w/ vehicle; half-life = 6 hours (p.119); peptides; heparin dose 50 U/ml.

P5676 Ito,H., Hayashi,I., Izumi,T., Majima,M. Bradykinin inhibits development of myocardial infarction through B-2 receptor signalling by increment of regional blood flow around the ischaemic lesions in rats. British Journal of Pharmacology 2003; 138(-1-):225-233. >>> FR-190997; aprotinin; SBTI; Saline; water; HCl; IV (vena cava, cervical vein); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; cardiovascular; FR-190997 (a nonpeptide mimic of bradykinin beta 2 agonist) was infused into the vena cava; aprotinin infused into the cervical vein; SBTI&aprotinin are plasma kallikrein inhibitors from soybeans.

P5668 Tanabe,K., Dohi,S., Matsuno,H., Hirade,K., Kozawa,O. Midazolam stimulates vascular endothelial growth factor release in aortic smooth muscle cells - Role of the mitogen-activated protein kinase superfamily. Anesthesiology 2003; 98(-5-):1147-1154. >>> Midazolam; IV (jugular); Rat; 2001D; 24 hours; Comparison of IV injections vs. IV infusion; midazolam is an intravenous anesthetic.

P5667 Thaete,L.G., Neerhof,M.G., Jilling,T., Caplan,M.S. Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 2003; 10(-3-):145-150. >>> Platelet-activating factor, carbamyl-; Saline; ethyl alcohol; IV (jugular); Rat (pregnant); 7 days; Controls received mp w/ vehicle; teratology; 1.5% ethyl alcohol used; PAF is a phospholipid..

P6973 Arap,W, Haedicke,M, Bernasconi,M, Kain,R, Rajotte,D  PNAS 2002; 99(-3-):1527-1531. >>> SMSIARL, phage; IV; Mice; ; Comparison of pellets vs. mp; peptides; cancer.

P6235 Kuenzler,K.A., Arthur,L.G., Schwartz,M.Z. A possible mechanism for prevention of intestinal programmed cell death after ischemia-reperfusion injury by hepatocyte growth factor pretreatment. Journal of Pediatric Surgery 2002; 37(-12-):1696-1699. >>> Hepatocyte growth factor, recomb. human; Tris buffer; IV (jugular); Rat; 1003D; 48-54 hours; Controls received mp w/ vehicle; peptides; ischemia (cardiac).

P6228 Nakamura,R., Kato,J., Kitamura,K., Onitsuka,H., Imamura,T., Marutsuka,K., Asada,Y., Kangawa,K., Eto,T. Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats. Cardiovascular Research 2002; 56(-3-):373-380. >>> Adrenomedullin, recomb.human; Saline; IV (left, jugular); Rat; 2004; 4 weeks; Controls received mp w/ vehicle and/or sham MI operation; functionality of mp verified by human and rat AM serum levels; stress/adverse reaction: (see pg. 375) to MI surgery, but no adverse reaction from mp.; cardiovascular; peptides.

P6168 Luo,Z.D., Calcutt,N.A., Higuera,E.S., Valder,C.R., Song,Y.H., Svensson,C.I., Myers,R.R. Injury type-specific calcium channel alpha 2 delta-1subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. Journal of Pharmacology and Experimental Therapeutics 2002; 303(-3-):1199-1205. >>> Vincristine; Saline, sterile; IV (jugular); Rat; 2002; 2 weeks; Behavioral study.

P5900 Kuenzler,K.A., Pearson,P.Y., Schwartz,M.Z. IL-11 pretreatment reduces cell death after intestinal ischemia-reperfusion. Journal of Surgical Research 2002; 108(-2-):268-272. >>> Interleukin-11; Saline; IV (jugular); Rat; 1003D; 48 hours; Controls received mp w/ vehicle; peptides; IL-11 was human recomb; ischemia (intestinal).

P5825 Obici,S., Zhang,B.B., Karkanias,G., Rossetti,L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nature Medicine 2002; 8(-12-):1376-1382. >>> Angiotensin II; Saline; IV; Rat; 2002; 3-7 days; Controls received mp w/ vehicle; cardiovascular.

P5580 Frago,L.M., Paneda,C., Dickson,S.L., Hewson,A.K., Argente,J., Chowen,J.A. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology 2002; 143(-10-):4113-4122. >>> Growth hormone; Growth hormone-rel. peptide; IV (jugular); rat; 2001; 7 days; controls received mp with saline; peptides.

P5554 Bowler,R.P., Sheng,H.X., Enghild,J.J., Pearlstein,R.D., Warner,D.S., Crapo,J.D. A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free Radical Biology and Medicine 2002; 33(-8-):1141-1152. >>> AEOL 10150; PBS; IV (jugular); Mice; 1003D; 6 hours; Controls received mp w/ vehicle; AEOL 10150 is a catalytic antioxidant metalloporphyrin; ischemia (cerebral).

P5516 Alavi,K., Schwartz,M.Z., Prasad,R., O'connor,D., Funanage,V. Leptin: a new growth factor for the small intestine. J.Pediatr.Surg. 2002; 37(-3-):327-330. >>> Leptin; BSA; IV; Rat; 2002; 14 days; Dose-response; peptides.

P5497 Ohwada,T., Ishibashi,T., Yaoita,H., Shindo,J., Noji,H., Ohkawara,H., Sugimoto,K., Sakamoto,T., Maehara,K., Maruyama,Y. Different contribution of apoptosis to the antiproliferative effects of L-arginine, enalapril and losartan on neointimal growth inhibition after balloon arterial injury. CIRCULATION JOURNAL 2002; 66(-10-):965-971. >>> Arginine, L-; Saline; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; L-Arginine plasma levels checked during pilot study; cardiovascular; restenosis.

P5491 Gruhn,N., Boesgaard,S., Andersen,C., Aldershvile,J. Nitroglycerin tolerance: Different mechanisms in vascular segments with or without intact endothelial function. Journal of Cardiovascular Pharmacology 2002; 40(-2-):201-209. >>> Nitroglycerin; losartan; Saline; ethanol; SC; IV; Rat; 2ML1; 3 days; multiple pumps per animal (2).

P5473 Erami,C., Zhang,H., Ho,J.G., French,D.M., Faber,J.E. Alpha 1-adrenoceptor stimulation directly induces growth of vascular wall in vivo. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-4-):H1577-H1587. >>> Norepinephrine; benoxathian; prazosin; KMD-3213; AH11110A; BMY-7378; propranolol; RX-821002; Ringer's, lactated; ascorbate; Perivascular; Rat; 2ML2; 14, 28 days; Tissue perfusion (left carotid wall); pumps replaced after 14 days for prazosin; catheter constructed from thin walled vinyl tubing and fenestrated at end placed near vessel; norepinephrine is a catecholamine; propranolol is a beta adrenoceptor antagonist; all other agents are antagonists alpha antagonists.

P5471 Inuzuka,S., Koga,S., Nishikido,M., Miyata,Y., Kanda,S., Shimokawa,I., Tanaka,M., Saito,Y., Kanetake,H. Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E-2. Immunology Letters 2002; 83(-2-):119-124. >>> Aminoguanidine; Saline; IV (jugular); Rat; ; Aminoguanidine is an inhibitor of inducible nitric oxide synthase.

P5463 O'Connor,T.P., Liesen,D.A., Mann,P.C., Rolando,L., Banz,W.J. A high isoflavone soy protein diet and intravenous genistein delay rejection of rat cardiac allografts. Journal of Nutrition 2002; 132(-8-):2283-2287. >>> V-PYRRO/NO; Saline; IV (femoral); Rat; 2ML2; 14 days; Pumps replaced after 11 days; V-PYRRO/NO is a liver-specific nitric oxide donor.

P5409 Yang,S., Zhou,M., Chaudry,I.H., Wang,P. Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis - Role of adrenomedullin and adrenomedullin binding protein-1. Annals of Surgery 2002; 236(-5-):625-633. >>> Adrenomedullin; Saline, sterile; IV (jugular); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; cardiovascular; peptides.

P5400 Ruan,H., Miles,P.D.G., Ladd,C.M., Ross,K., Golub,T.R., Olefsky,J.M., Lodish,H.F. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha-Implications for insulin resistance. Diabetes 2002; 51(-11-):3176-3188. >>> Tumor necrosis factor-a; PBS; BSA; IV (mesenteric); Rat; 2001D; 2ML1; 4 days; 24 hours; Controls received mp w/ vehicle; peptides; 1% BSA used.

P5389 Kagiyama,S., Eguchi,S., Frank,G.D., Inagami,T., Zhang,Y.C., Phillips,M.I. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation 2002; 106(-8-):909-912. >>> Angiotensin II; Oligodeoxynucleotide, antisense; SC; IV; Rat; 2002; 2ML4; 14 days; Antisense; multiple pumps per animal (2); 2002 pump implanted SC for Ang II delivery and 2ML2 used for IV administration of antisense.

P5346 Lyons,C.A., Beharry,K.D., Nishihara,K.C., Akmal,Y., Ren,Z.Y., Chang,E., Nageotte,M.P. Regulation of matrix metalloproteinases (type IV collagenases) and their inhibitors in the virgin, timed pregnant, and postpartum rat uterus and cervix by prostaglandin E-2-cyclic adenosine monophosphate. American Journal of Obstetrics and Gynecology 2002; 187(-1-):202-208. >>> Prostaglandin E2; IV (femoral); Rat; Rat (pregnant); 24 hours; Controls received mp w/ saline; catheter was filled with enough saline to provide a 3 hour recovery prior to onset of PGE2 delivery.

P5330 Ramchandra,R., Barrett,C.J., Guild,S.J., Malpas,S.C. Neural control of the renal vasculature in angiotensin II-induced hypertension. Clinical and Experimental Pharmacology and Physiology 2002; 29(-10-):867-872. >>> Angiotensin II; IV (jugular); Rabbit; 2ML4; 7 weeks; Long-term study, pumps replaced after 4 weeks; cardiovascular.

P5314 Sheng,H.X., Enghild,J.J., Bowler,R., Patel,M., Batinic-Haberle,I., Calvi,C.L., Day,B.J., Pearlstein,R.D., Crapo,J.D., Warner,D.S. Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free Radical Biology and Medicine 2002; 33(-7-):947-961. >>> AEOL 10150; PBS; IV (jugular); Mice; 1003D; 3 days; Controls received mp w/ vehicle; plasma levels of AEOL 10150 determined by HPLC; ischemia (cerebral).

P5282 Rabchevsky,A.G., Fugaccia,I., Sullivan,P.G., Blades,D.A., Scheff,S.W. Efficacy of methylprednisolone therapy for the injured rat spinal cord. J Neurosci.Res 2002/4/1; 68(-1-):7-18. >>> Methylprednisolone; Saline; IV (jugular); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; functionality verified by residual volume; methylprednisolone sodium succinate used.

P5281 Hermans,J.J., van Essen,H., Struijker-Boudier,H.A., Johnson,R.M., Theeuwes,F., Smits,J.F. Pharmacokinetic advantage of intrapericardially applied substances in the rat. J Pharmacol Exp.Ther 2002/5; 301(-2-):672-678. >>> Heparin; Fibroblast growth factor 2; Immunoglobulin G, rat; PBS; Albumin, rat serum; fluorescein; texas red; IV (jugular); intrapericardial; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality verified by measuring drug concentration in residual volume; plasma and pericardial fluid drug levels checked; comparison of bolus injection vs. mp; cardiovascular; DURECT-authored; rhFGF and rat serum albumin labeled w/ Texas red; rat IgG was labeled w/ fluorescein Isothiocyanate (FITC).

P5271 Davies,M.M., Mathur,P., Carnochan,P., Saini,S., Allen-Mersh,T.G. Effect of manipulation of primary tumour vascularity on metastasis in an adenocarcinoma model. Br.J Cancer 2002/1/7; 86(-1-):123-129. >>> Fibroblast growth factor, basic; Saline; IV (jugular); Intratumoral; Rat; 2004; 28 days; Controls received mp w/ vehicle; tissue perfusion (intratumoral); cancer; peptides; bFGF delivered either by systemic IV infusion or intratumorally.

P5217 Alexander,B.T., Cockrell,K.L., Massey,M.B., Bennett,W.A., Granger,J.P. Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression. Am.J Hypertens 2002; 15(-2 Pt 1-):170-175. >>> Tumor necrosis factor-a; Saline; IV (jugular); Rat (pregnant); 2002; 5 days; Controls received mp w/ vehicle; functionality verified by plasma levels; peptides; recomb. rat TNF-a used; hypertension.

P5148 Kuenzler,K.A., Pearson,P.Y., Schwartz,M.Z. Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury. Journal of Pediatric Surgery 2002; 37(--):457-459. >>> Interleukin-11; Saline; IV (jugular); rat; 1003D; 3 days; controls received mp w/ vehicle; peptides; ischemia (bowel).

P5147 Brehm,B.R., Wolf,S.C., Freudenberg,J., Friedmann,F., Heinle,H., Schulze-Osthoff,K. Modulation of the beta-adrenergic receptor system of vascular smooth muscle cells in vitro and in vivo by chronically elevated endothelin-1 levels. Biochemical Pharmacology 2002; 63(--):1361-1369. >>> Endothelin-1; Saline; IV (superior vena cava); rat; 2ML4; 3 weeks; controls received mp w/ vehicle; functionality of mp verfied by ET-1 levels; cardiovascular; peptides.

P5144 Pronko,P.S., Jarvelainen,H.A., Lindros,K.O. Acinar distribution of rat liver arylamine N-acetyltransferase: Effect of chronic ethanol and endotoxin exposure. PHARMACOLOGY&TOXICOLOGY 2002; 90(--):150-154. >>> Endotoxin, LPS; IV; rat; 4 weeks; toxicology.

P5132 Yang,R.H., Ogasawara,A.K., Zioncheck,T.F., Ren,Z., He,G.W., DeGuzman,G.G., Pelletier,N., Shen,B.Q., Bunting,S., Jin,H.K. Exaggerated hypotensive effect of vascular endothelial growth factor in spontaneously hypertensive rats. Hypertension 2002; 39(--):815-820. >>> Vascular Endothelial Growth Factor; Saline; IV (jugular); rat; 7 days; controls received mp w/ vehicle; cardiovascular; antihypertensive.

P5127 Pham,D., Jeng,A.Y., Plante,S., Escher,E., Battistini,B. Inhibition of endothelin-converting enzyme for protection against neointimal proliferation following balloon angioplasty of the rat carotid artery. Canadian Journal of Physiology and Pharmacology 2002; 80(--):450-457. >>> CGS-26303; CGS-24592; CGS-26393; Sodium hydroxide; Sodium carbonate; IP; IV (jugular); rat; 2ML2; 14 days; controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; dose-response (p. 454); cardiovascular; enzyme inhibitors (neutral endopeptidase, endothelin-converting enzyme).

P5100 Loot,A.E., Roks,A.J., Henning,R.H., Tio,R.A., Suurmeijer,A.J., Boomsma,F., van Gilst,W.H. Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats. Circulation 2002/4/2; 105(-13-):1548-1550. >>> Angiotensin-(1-7); Saline; IV; rat; 2004; 8 weeks; controls received mp w/ vehicle; functionality of mp verified by plasma Ang(1-7) levels; long-term study, pumps replaced after 4 weeks; cardiovascular; peptides.

P5087 Dufourcq,P., Couffinhal,T., Alzieu,P., Daret,D., Moreau,C., Duplaa,C., Bonnet,J. Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation. Cardiovascular Research 2002; 53(--):952-962. >>> Antibody, monoclonal anti-vitronectin; Antibody, monoclonal anti-B3 integrin; Antibody, monoclonal anti-avB5 integrin; PBS; Immunoglobulin G, non-immune; perivascular (carotid artery adventitia); rat; 7 days; controls received control immunoglobulin; tissue perfusion (corotid adventitia); cardiovascular; peptides.

P5059 Davies,M.M., Burke,D., Carnochan,P., Glover,C., Kaur,S., Allen-Mersh,T.G. Basic fibroblast growth factor infusion increases tumour vascularity, blood flow and chemotherapy uptake. Acta Oncologica 2002; 41(-1-):84-90. >>> BAY-55-9837; Saline; SC; IV (jugular); rat; 2002; 10, 14, or 28 days; controls received mp w/ vehicle; peptides; BAY-55-9837 is a Vasoactive Intestinal Peptide shared type 2 receptor agonist.

P5799 Kanno,S., Wu,Y-J.L., Lee,P.C., Billiar,T.R, Ho,C. Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. Circulation 2001; 104(-8-):945-950. >>> L-NIO; IV (jugular); Rat; 35 days; Controls received mp w/ saline; enzyme inhibitor (Nitric oxide synthase); L-NIO is N-iminoethyl-L-ornithine, a potent NOS inhibitor.

P5192 Briest,W., Holzl,A., Rassler,B., Deten,A., Leicht,M., Baba,H.A., Zimmer,H.G. Cardiac remodeling after long term norepinephrine treatment in rats. Cardiovascular Research 2001; 52(--):265-273. >>> Norepinephrine; nisoldipin; Saline; ascorbic acid; ethanol; IP; IV (jugular); Rat; 3 or 14 days; Controls received mp w/ vehicle; comparison of infusion pump vs. mp; cardiovascular; Norepinephrine was infused IV for 14 days in saline w/ 0.01% ascorbic acid; nisoldipin, a calcium channel blocker, was delivered IP for 3 days in absolute ethanol.

P5029 Eatman,D., Wang,M., Socci,R.R., Thierry-Palmer,M., Emmett,N., Bayorh,M.A. Gender differences in the attenuation of salt-induced hypertension by angiotensin (1-7). Peptides 2001; 22(--):927-933. >>> Angiotensin-(1-7); Saline; IV (jugular); rat; 2ML2; 2 weeks; controls received mp w/ vehicle; peptides.

P4982 Matsuo,Y., Matsuo,Y., Mihara,S., Ninomiya,M., Fujimoto,M. Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats. Stroke 2001; 32(--):2143-2148. >>> S-0139; Saline; IV (femoral vein); rat; 2001D; 24 hours; functionality of mp verified by plasma endothelin levels; dose-response (graph p. 2145); S-0139 is a selective Endothelin A antagonist; neuroprotection.

P4970 Ortiz,M.C., Sanabria,E., Manriquez,M.C., Romero,J.C., Juncos,L.A. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 2001; 37(--):505-510. >>> Angiotensin II; Saline; IV (jugular); rat; 15 days; controls received mp w/ vehicle; functionality of mp verified by plasma Angiotensin II levels, systolic blood pressure; p. 504 paragraph 2 discusses Ang II plasma levels;.

P4953 Pearson,P.Y., O'Connor,D.M., Schwartz,M.Z. Novel effect of leptin on small intestine adaptation. Journal of Surgical Research 2001; 97(--):192-195. >>> Leptin; Bovine serum albumin; IV (jugular); rat; 2002; 14 days; controls received mp w/ vehicle; peptides; rats had undergone 80% small intestine resection; Short Bowel Syndrome;.

P4938 Cabot,C., Grasa,M.D.M., Massanes,R.M., de Matteis,R., Cinti,S., Fernandez-Lopez,J.A., Remesar,X., Alemany,M. Oleoyl-estrone does not have direct estrogenic effects on rats. LIFE SCIENCES 2001; 69(--):749-761. >>> Estrone, oleoyl-; Liposome suspension; IV (jugular); rat; 2ML2; 3, 6, 10 days; controls received mp w/ vehicle; functionality of mp verified by plasma estrone levels; comparison of oral gavage vs. mp; dose-response (p. 756); liposome suspension contained 20% lipid; "We found that acyl-estrone concentrations in plasma were in a similar range using either IV or oral administration; however, in the IV treatment, free estrone levels were 3.5-fold higher and those of B-estradiol were 4-fold higher than the corresponding values found in orally-treated animals". p. 753-54;.

P4831 Carstens,E., Anderson,K.A., Simons,C.T., Carstens,M.I., Jinks,S.L. Analgesia induced by chronic nicotine infusion in rats - Differences by gender and pain test. Psychopharmacology 2001; 157(--):40-45. >>> Nicotine;; Saline;; IV (jugular);; rat;; 2ML2;; 2 weeks;; Functionality of mp verified by previous study results, pump content after sacrifice; dose-response (p. 42); no stress (p. 41); Nicotine was in its free base form;.

P4812 Nakata,T., Takeda,K., Harada,S., Oguni,A., Hatta,T., Kawa,T., Itoh,H., Sasaki,S., Nakagawa,M. Role of the central nervous system in the development of hypertension produced by chronic nitric oxide blockade in rats.. Hypertension Res 2001; 24(-1-):39-45. >>> LU 135252;; PBS;; IV (femoral vein);; rat;; 2001;; 2 weeks;; Controls received mp w/ vehicle; LU 135252 is an endothelin receptor antagonist;.

P4794 Wiig,H., Tenstad,O. Interstitial exclusion of positively and negatively charged IgG in rat skin and muscle.. American Journal of Physiology-Heart and Circulatory Physiology 2001; 280(--):H1505-H1512. >>> Antibody, Immunoglobulin, G1; Antibody, Immunoglobulin, G4;; Radio-isotopes; 125I tracer; 131I tracer;; IV (jugular);; rat;; 2001;; 120 - 168 hours;; Functionality of mp verified by plasma levels (Fig 1 p. H1507); peptides; IgG's were radioactive tracers;.

P4789 Alexander,B.T., Cockrell,K.L., Rinewalt,A.N., Herrington,J.N., Granger,J.P. Enhanced renal expression of preproendothelin mRNA during chronic angiotensin II hypertension.. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2001; 280(--):R1388-R1392. >>> Angiotensin II;; Saline;; IV (jugular);; rat;; 2002;; 2 weeks;; Controls received mp w/ vehicle; cardiovascular.

P4732 Correia,M.L.G, Morgan,D.A, Sivitz,W.I, Mark,A.L, Haynes,W.G  Hypertension 2001; 37(--):936-942. >>> Leptin, recomb. mouse;; IV (jugular); CSF/CNS (third ventricle);; rat;; 2002; 2004; 2ML4;; 2, 4 weeks;; Controls received mp w/ vehicle; functionality of mp verified by CSF and plasma leptin levels; peptides; antihypertensive; Methylene blue stain and microtone slicing to enfure cannula placement; High and low dose studies using 2002, 2004, respectively;.

P8575 Pavco,P.A., Bouhana,K.S., Gallegos,A.M., Agrawal,A., Blanchard,K.S., Grimm,S.L., Jensen,K.L., Andrews,L.E., Wincott,F.E., Pitot,P.A. Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin Cancer Res 2000; 6(-5-):2094-2103. >>> Ribozyme, anti-Flt-1; ribozyme, anti-KDR; ribozyme, attenuated; Saline; IV (jugular); SC; Mice; mice (nude); 2002; 14,28 days; Controls received mp w/ vehicle or attenuated control; dose-response (fig. 2); pumps replaced after 18 days; stress/adverse reaction (see pg. 2096);<10% of animals removed from study due to catheter failure or animal not surviving pump implantation; half-life (p. 2100) IV and SC similar; cancer (lung carcinoma, colorectal carcinoma, liver metastasis); animal info (female, C57BL/6, 6-8 weeks old, male, nude, 6-8 weeks old); antiangiogenic, 80% bioavailable after SC administration; targets VEGF receptor mRNA; anti-Flt-1 ribozyme also known as angiozyme.

P6297 Talpade,D.J., Greene,J.G., Higgins,D.S.Jr., Greenamyre,T. In Vivo Labeling of Mitochondrial Complex I (NADH: Ubiquinone Oxidoreductase) in Rat Brain Using [3H]Dihydrorotenone. Journal of Neurochemistry 2000; 75(-6-):2611-2621. >>> Rotenone; azide, sodium; PEG; water; DMSO; SC; IV (jugular); Rat; 2 months; Controls received mp w/ vehicle; [3H]Dihydrorotenone administered via IV jugular infusion w/o mp tygon tubing used; rotenone dissolved in PEG/DMSO; azide dissolved in water.

P5557 Senzaki,H., Paolocci,N., Gluzband,Y.A., Lindsey,M.L., Janicki,J.S., Crow,M.T., Kass,D.A. b-blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction. Circulation Research 2000; 86(--):807-815. >>> Angiotensin II; Acetic acid; IV; Dog; 2ML1; 6-7 days; Cardiovascular; peptides.

P5257 Reglodi,D., Somogyvari-Vigh,A., Vigh,S., Kozicz,T., Arimura,A. Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat. Stroke 2000/6; 31(-6-):1411-1417. >>> PACAP38; BSA; saline; IV (jugular); Rat; 48 hours; Controls received mp w/ vehicle; good methods (p.1412); peptides; PACAP38 (bachem) is pituitary adenylate cyclase-activating polypeptide; micro-rethane tubing used; PACAP38 acts as a neurotransmitts, hypophysiotropic hormone, neuromodulator, neurotrophic and neuroprotective; pump model not specified (possibly 1003D: 1 ul/hr flow rate).

P5249 Sharkey,E.M., O'Neill,H.B., Kavarana,M.J., Wang,H., Creighton,D.J., Sentz,D.L., Eiseman,J.L. Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I. Cancer Chemother.Pharmacol 2000; 46(-2-):156-166. >>> Glutathione, S-(N-p-chlorophenyl-N-hydroxycarbamoyl); Cyclodextrin, B-; IV (jugular); Mice; 2002; 14 days; Comparison of IV injections vs. mp; enzyme inhibitor; 20% hydroxypropyl-beta-cyclodextrin used; CHG (Et)2 is an enediol analog inhibitor of glycoxalase in its ester prodrug form; colon adenocarcinoma and prostate cancer.

P5004 Shin,L.H., Dovgan,P.S., Nypaver,T.J., Carretero,O.A., Beierwaltes,W.H. Role of neuropeptide Y in the development of two-kidney, one-clip renovascular hypertension in the rat. JOURNAL OF VASCULAR SURGERY 2000; 32(--):1015-1021. >>> BIB-03304TF; Water; IV (femoral); rat; 4 weeks; controls received sham operation; functionality of mp verified by residual volume; dose-response (graphs p. 1018); peptides; BIB-03304TF is a vasoactive neuropeptide y receptor antagonist; PE-60 tubing fused to PE-10 tubing;.

P4841 Prasad,R., Alavi,K., Schwartz,M.Z. Glucagonlike peptide-2 analogue enhances intestinal mucosal mass and absorptive function after ischemia-reperfusion injury. Journal of Pediatric Surgery 2000; 35(-11-):1537-1539. >>> Glucagon-like peptide-2 analog; Saline; IV (jugular); rat; 1003D; 3 days; controls received mp w/vehicle; peptides; ischemia.

P4793 Ivanov,A.I., Kulchitsky,V.A., Sugimoto,N., Simons,C.T., Romanovsky,A.A. Does the formation of lipopolysaccharide tolerance require intact vagal innervation of the liver?. Autonomic Neuroscience-Basic&Clinical 2000; 85(--):111-118. >>> Endotoxin, E. coli;; Saline;; IV (jugular);; rat;; 2004;; 28 days;; Controls received mp w/ vehicle; functionality of mp verified by colonic temp in E. coli delivery; tolerance; silastic catheter used;.

P4766 Minami,H., Tada,K., Chowdhury,N.R., Chowdhury,J.R., Onji,M. Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine. Journal of Hepatology 2000; 33(--):183-188. >>> Hepatocyte growth factor; Triiodothyronine;; Saline; Heparin, sodium;; IV (portal vein);; rat;; 24 hours;; Comparison of portal vein injections vs. mp; cancer; immunology; peptides; HGH used was recombinant human..

P4740 Betarbet,R, Sherer,T.B, MacKenzie,G, Garcia-Osuna,M, Panov,A.V, Greenamyre,J.T  Nature Neuroscience 2000; 3(-12-):1301-1306. >>> Rotenone;; DMSO; PEG; IV (jugular);; rat;; 2ML1; 2ML4;; various: 1 to 5+ weeks; Controls received mp w/ vehicle; dose-response (fig. 1, p. 1302); pumps replaced after 28 days; neurodegenerative (Parkinson's disease); rotenone is a lipophilic pesticide; rotenone was dissolved in 50% DMSO / 50% polyethylene glycol; tygon microbore tubing used;.

P4736 Farrant,G, Abu-Zidan,F.M, Liu,X., Zwi,L.J, Windsor,J.A  Contemporary Topics 2000; 39(-4-):36-39. >>> Caerulein;; Saline;; IV (femoral);; rat;; 2001D;; 6 hours;; Controls received mp w/ vehicle; 2 catheters disconnected from pump, PE - 55 tubing used; good methods p. 36; peptides; Caerulein, a natural peptide from amphibian skin, causes reversible rat pancreatitis; most groups received 6 hr infusion; 1 control group received 24-hr saline infusion; pump advantages (p. 38);.

P4724 Cleton,A, Altorf,B.A, Voskuyl,R.A, Danhof,M  European Journal of Pharmacology 2000; 12(--):141-150. >>> Tiagabine;; Saline;; IV (jugular);; rat;; 2ML2;; 14 days;; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; dose-response (graph p. 145); comparison of IV injections vs. mp; Tiagabine is a GABA uptake inhibitor; seizure prevention; Epilepsy;.

P4707 Alavi,K, Schwartz,M.Z., Palazzo,J.P, Prasad,R  Journal of Pediatric Surgery 2000; 35(-6-):847-851. >>> Glucagon-like peptide-2;; PBS;; IV (jugular);; rat;; 2002;; 14 days;; Controls received no treatment; peptides; GLP-2 is an intestinal growth factor;.

P4702 Ishizaka,N., Aizawa,T, Mori,I., Taguchi,J.-I, Yazaki,Y, Nagai,R, Ohno,M  Am.J.Physiol.Heart Circ.Physiol. 2000; 279(--):H672-H678. >>> Angiotensin II; Norepinephrine;; SC; IV (jugular vein);; rat;; 2001;; 7 days;; Controls received mp w/ vehicle; cardiovascular; antihypertensive; Angiotensin II infused SC; Norepinephrine infused IV;.

P4628 Sjöstrand,M, Holmäng,A., Lönnroth,P  Am.J.Physiol.(Endocrinol.Metab.39) 2000; 276(--):E151-E154. >>> Inulin; 14C tracer; Radio-isotopes; IV(jugular); rat; 2001; ; microdialysis.

P4627 Minami,H., Tada,K, Chowdhury,N.R, Chowdhury,J.R, Morikazu,O  Journal of Hepatology 2000; 33(--):183-188. >>> Hepatocyte growth factor; NaCl; Heparin; IV; rat; 24 hours; comparison of IV injections vs. mp; peptides; heparin dose 50 U/kg.

P4485 Tejeda,M, Gaal,D., Schwab,R.E, Pap,A, Szúts,T, Keri,GY. Influence of various administration routes on the antitumor efficacy of TT-232, a novel somatostatin analog.. Anticancer Res. 2000; 20(--):1023-1028. >>> TT-232; Acetic acid; Water, distilled; Sodium acetate; Marmite;; SC; IV; Mice; 2001; 2002; 1, 2 weeks; comparison of IV + SC injections vs. mp infusion; cancer; peptides; "continuous infusion using an implantable minipump proved to be the most effective route of treatment in both SC or IV administration against S-180 sarcoma." (P. 1026).

P4429 Jonassen,T.E.N., Promeneur,D, Christensen,S., Petersen,J.S., Nielsen,S  Am.J.Physiological.Renal Physiol. 2000; 278(--):F246-F256. >>> Canrenoate, potassium;; IV (jugular);; rat;; 2ML4;; ; aldosterone receptor antagonist; silastic catheter used;.

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