References on the Administration of Agents to Primates Using
ALZET^® Osmotic Pumps

1. Baboon

P8047 Sherwin,J.R.A., Sharkey,A.M., Cameo,P., Mavrogianis,P.M., Catalano,R.D., Edassery,S., Fazleabas,A.T. Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007; 148(-2-):618-626. >>> Gonadotrophin, human chorionic; Oviductal; Monkey (baboon); 5 days; Animal info (female, adult).

P7516 Strakova,Z., Mavrogianis,P., Meng,X.M., Hastings,J.M., Jackson,K.S., Cameo,P., Brudney,A., Knight,O., Fazleabas,A.T. In vivo infusion of interleukin-1 beta and chorionic gonadotropin induces endometrial changes that mimic early pregnancy events in the baboon. Endocrinology 2005; 146(-9-):4097-4104. >>> Gonadotrophin, human chorionic, recomb.; interleukin-1, beta, recomb. human; interleukin-1 receptor antagonist, recomb. human; Oviductal; Monkey (baboon); 10 days; Controls received no treatment; pumps replaced at day 5; animal info (female, adult).

1353 Berceli,S.A., Davies,M.G., Kenagy,R.D., Clowes,A.W. Flow-induced neointimal regression in baboon polytetrafluoroethylene g rafts is associated with decreased cell proliferation and increased ap optosis. JOURNAL OF VASCULAR SURGERY 2002; 36(-6-):1248-1255. >>> ; .

P5475 Shade,R.E., Blair-West,J.R., Carey,K.D., Madden,L.J., Weisinger,R.S., Denton,D.A. Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1070-R1078. >>> Angiotensin II; aldosterone; Saline; ethanol; SC; CSF/CNS; Monkey (baboon); 49 days; Controls received mp w/ vehicle; long-term study, pumps replaced every 7 days (6 times); angiotensin II diluted in saline and infused ICV; aldosterone diluted in 10% ethanol in saline and infused SC; some animals implanted w/ 2 pumps.

P5297 Hart,C.E., Kraiss,L.W., Vergel,S., Gilbertson,D., Kenagy,R., Kirkman,T., Crandall,D.L., Tickle,S., Finney,H., Yarranton,G., Clowes,A.W. PDGFbeta receptor blockade inhibits intimal hyperplasia in the baboon. Circulation 1999/2/2; 99(-4-):564-569. >>> Heparin, porcine; Saline; IV (femoral); Monkey (baboon); 4, 28, 56 days; Controls received mp w/ vehicle; pumps replaced after 28 days; cardiovascular; multiple pumps per animal (2).

P4163 Fazleabas,A.T., Donnelly,K.M., Srinivasan,S., Fortman,J.D., Miller,J.B. Modulation of the baboon (papio anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity. Proc.Natl.Acad.Sci.USA 1999; 96(--):2543-2548. >>> Gonadotrophin, recomb. human chorionic; Intraovarian (corpus luteum); Monkey (baboon); 2ML1; 7 days; tissue perfusion (corpus luteum).

P4060 Blair-West,J.R., Carey,K.D., Denton,D.A., Weisinger,R.S., Shade,R.E. Evidence that brain angiotensin II is involved in both thirst and sodium appetite in baboons. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.44) 1998; 275(--):R1639-R1646. >>> Angiotensin II; Losartan potassium; ZD-7155; Ethanol; CSF, artificial;; SC; CSF/CNS;; Monkey (baboon); 2ML1; 2ML2; 2ML4; no duration posted; controls received mp w/vehicle; amoxicillin and buprenorphine given post-operatively; good methods; aCSF delivered during 1-2 week surgical recovery period; vehicle and compound-filled pumps were alternated; some pumps were filled with peptide and antagonist; ZD-7155 is an AT1 receptor antagonist; peptides; antihypertensive.

P1880 Kang,I.S., Kuehl,T.J., Siler-Khodr,T.M. Effect of treatment with gonadotropin-releasing hormone analogues on pregnancy outcome in the baboon. Fertil.Steril. 1989; 52(-5-):846-853. >>> Luteinizing HRH antagonist; Water; SC; Monkey (baboon, pregnant); 7 days; no comment posted.

P1465 Brailowsky,S., Silva-Barrat,C., Menini,C., Riche,D., Naquet,R. Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio. Electroencephalogr.Clin.Neurophysiol. 1989; 72(--):147-156. >>> Aminobutyric acid, Y-; Saline; CSF/CNS; Monkey (baboon); 2ML1; 7 days; functionality of mp verified by removing and opening; pumps replaced once w/ saline-filled mp.

P1023 Brailowsky,S., Menini,C., Silva-Barrat,C., Naquet,R. Epileptogenic y-aminobutyric acid-withdrawal syndrome after chronic, intracortical infusion in baboons. Neurosci.Lett. 1987; 74(--):75-80. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (frontal cortex); Monkey (baboon); 2ML1; no duration posted; controls received mp w/vehicle; mp connected to intracerebral cannula; agent filled mp replaced after 7 days with saline filled mp; tissue perfusion (frontal cortex).

P0035 Hagino,N., Nakamoto,O., Kunz,Y., Arimura,A., Coy,D.H., Schally,A.V. Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon. Acta Endocrinol. 1979; 91(-2-):217-223. >>> Luteinizing HRH agonist; Saline; SC; Monkey (baboon); 7 days; peptides.

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2. Marmoset

P8143 Griffiths,G.D., Hornby,R.J., Jagger,C.P., Brown,A.P., Stoten,A., Pearce,P.C., Scott,L., Pritchard,D.I. Development of methods to measure humoral immune responses against selected antigens in the common marmoset (Callithrix jacchus) and the effect of pyridostigmine bromide administration. INTERNATIONAL IMMUNOPHARMACOLOGY 2006; 6(-12-):1755-1764. >>> Pyridostigmine bromide; Saline, sterile isotonic; SC; Marmoset; 28 days; Controls received mp w/ vehicle; no stress (see p.1759,1762); immunology; animal info (male, female, 300-500g.); mp primed 40 hours; "delivery by pump ensured the animals would receive an appropriate dose of the drug over the desired time period.", oral delivery "would introduce unacceptable stress into the experiment and presentation in food was discounted because of difficulties in estimating the dose administered." (p.1757).

P8082 Hornby,R.J., Pearce,P.C., Bowditch,A.P., Scott,L., Griffiths,G.D. Multiple vaccine and pyridostigmine bromide interactions in the common marmoset Callithrix jacchus: Immunological and endocrinological effects. INTERNATIONAL IMMUNOPHARMACOLOGY 2006; 6(-12-):1765-1779. >>> Pyridostigmine bromide; Saline, sterile isotonic; SC; Marmoset; 2004; 28 days; Controls received mp w/ vehicle; no stress (see p.1776); immunology; animal info (female, vasectomized male, 331-565g. 2-5.5 yrs. old); mp primed 40 hours.

P6741 Van Helden,H.P.M., Vanwersch,R.A.P., Kuijpers,W.C., Trap,H.C., Philippens,I.H.C., Benschop,H.P. Low levels of Sarin affect the EEG in marmoset monkeys: a pilot study. Journal of Applied Toxicology 2004; 24(-6-):475-483. >>> Pyridostigmine bromide; Propylene glycol: ethanol; acidic acid, glacial; water, distilled; SC; Marmoset; 2002; ; Controls received mp w/ vehicle; toxicology; sarin vapor.

P6551 Van Helden,H.P.M., Trap,H.C., Kuijpers,W.C., Oostdijk,J.P., Benschop,H.P., Langenberg,J.P. Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis. Journal of Applied Toxicology 2004; 24(-1-):59-68. >>> Pyridostigmine bromide; Propylene glycol; ethanol; water; acetic acid, glacial; SC; Guinea-pig; marmoset; 2002; 4 days; Controls received mp w/ vehicle; toxicology.

P6348 Marshall,J.W.B., Ridley,R.M. Assessment of cognitive and motor deficits in a marmoset model of stroke. ILAR JOURNAL 2003; 44(-2-):153-160. >>> Clomethiazole; AR-R15896AR; NXY-059; Saline; SC; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; pumps replaced every 24 hours; ischemia (cerebral); neuroprotective; post op. care (incubator); behavioral study.

P6150 Marshall,J.W.B., Cummings,R.M., Bowes,L.J., Ridley,R.M., Green,A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion. Stroke 2003; 34(-9-):2228-2233. >>> NXY-059; Saline; IV; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; NXY-059 plasma levels taken; pumps replaced every 24 hours; post op. care (flunixin meglumine); behavior study; neuroprotective; ischemia (cerebral).

P5707 Muggleton,N.G., Bowditch,A.P., Crofts,H.S., Scott,E.A.M., Pearce,P.C. Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioral effects of organophosphates in the common marmoset (Callithrix jacchus). Psychopharmacology 2003; 166(-3-):212-220. >>> Physostigmine salicylate; scopolamine hydrobromide; Saline; SC; Monkey (marmoset); 2002; 14 days; Controls received mp w/ vehicle; behavioral testing; agents infused via same pumps; toxicology.

P4851 Marshall,J.W.B., Duffin,K.J., Green,A.R., Ridley,R.R. NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 2001; 32(--):190-198. >>> NXY-059; Saline; SC; monkey (marmoset); 2001D; 48 hours; controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; pumps replaced after 24 hours; NXY-059 is a novel free-radical trapping agent; multiple pumps per animal (2) used simultaneously; ischemia (cerebral).

P4292 Marshall,J.W.B., Cross,A.J., Ridley,R.M. Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species. Experimental Neurology 1999; 156(--):121-129. >>> Clomethiazole;; IP;; monkey (marmoset);; 2001D;; 24 hours;; clomethiazole is neuroprotective in rodents following ischemia; ischemia (cerebral).

P1622 Wood,J.M., Jobber,R.A., Baum,H.-P., de Gasparo,M., Nussberger,J. Biochemical effects of prolonged renin inhibition in marmosets. J.Hypertens. 1989; 7(-8-):615-618. >>> CGP-29287; Methylcellulose; Saline; IP; monkey (marmoset); 2002; 7 days; dose-response; CGP-29287 is a renin inhibitor.

P1292 Wood,J.M., Baum,H.-P., Jobber,R.A., Neisius,D. Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets. J.Cardiovasc.Pharmacol. 1987; 10(-7-):S96-S98. >>> CGP-29287; IP; monkey (marmoset); 2002; 14 days; dose-response; only high dose affected bp; mp removed after delivery.

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3. Monkey (all)

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