References on the Administration of Prolactin Using
ALZET^® Osmotic Pumps

P8503 Williams,V.L., DeGuzman,A., Dang,H., Kawaminami,M., Ho,T.W.C., Carter,D.G., Walker,A.M. Common and specific effects of the two major forms of prolactin in the rat testis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 293(-6-):E1795-E1803. >>> Prolactin; Saline; SC; Rat; 4 weeks; Controls received mp w/ vehicle; plasma levels taken; peptides; animal info (male).

P8425 Gregg,C., Shikar,V., Larsen,P., Mak,G., Chojnacki,A., Yong,V.W., Weiss,S. White matter plasticity and enhanced remyelination in the maternal CNS. Journal of Neuroscience 2007; 27(-8-):1812-1823. >>> Prolactin, recomb. mouse; Saline; albumin mouse serum; SC; Mice; 1007D; 2.5 days; Controls received mp w/ vehicle; peptides; animal info (female, CD-1, 6-8 wks old).

P8083 Hilfiker-Kleiner,D., Kaminski,K., Podewski,E., Bonda,T., Schaefer,A., Sliwa,K., Forster,O., Quint,A., Landmesser,U., Doerries,C., Luchtefeld,M., Poli,V., Schneider,M.D., Balligand,J.L., Desjardins,F., Ansari,A., Struman,I., Nguyen,N.Q.N., Zschemisch,N.H., Klein,G., Heusch,G., Schulz,R., Hilfiker,A., Drexler,H. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 2007; 128(-3-):589-600. >>> Prolactin, recomb; Mice; 3 weeks; Controls received mp w/ saline; cardiovascular; peptides; animal info (female).

P8230 Craven,A.J., Nixon,A.J., Ashby,M.G., Ormandy,C.J., Blazek,K., Wilkins,R.J., Pearson,A.J. Prolactin delays hair regrowth in mice. Journal of Endocrinology 2006; 191(-2-):415-425. >>> Prolactin, ovine; domperidone; Sodium bicarbonate buffer; PEG 400; SC; Mice; 1003D; 1007D; 1002; 3, 12, 14, days; Controls received no treatment; functionality of mp verified by plasma prolactin levels; animal info (Balb/c, 18-30 days old).

P7665 Guzman,E.A., Chen,Y.H., Langowski,J.L., De Guzman,A., Lo,H.L., Walter,B., Muller,H.K., Walker,A.M., Owen,L.B. Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin. Journal of Neuroimmunology 2005; 170(-1-2-):31-40. >>> Prolactin, recomb.; prolactin, S179D; Saline; SC; Mice; 2004; 21 days; Controls received mp w/ vehicle; immunology; animal info (male, C3H/HeJ or C3H/HeJ-TnFsF6gld, 10-12 wk. old).

P7620 Obal,F.Jr, Garcia-Garcia,F., Kacsoh,B., Taishi,P., Bohnet,S., Horseman,N.D., Krueger,J.M. Rapid eye movement sleep is reduced in prolactin-deficient mice. Journal of Neuroscience 2005; 25(-44-):10282-10289. >>> Prolactin, murine; Saline, physiological; SC; Mice; 1002; 11-12 days; Controls received mp w/ vehicle; animal info (C57BL/6J, pRL, KO, male, 25-30 g, 8-16 wk old).

P7450 Leonard,S.T., izadeh-Naderi,R., Stokes,K., Ferkin,M.H. The role of prolactin and testosterone in mediating seasonal differences in the self-grooming behavior of male meadow voles, Microtus pennsylvanicus. PHYSIOLOGY&BEHAVIOR 2005; 85(-4-):461-468. >>> Bromocriptine; prolactin, ovine; Saline, sterile; SC; Prairie vole; 2004; ; Controls received mp w/ vehicle; replacement therapy (gonadectomy); animal info (male, meadow); animals also received testosterone via silastic implant at same time.

P7199 Nasir,I., Kedees,M.H., Ehrlich,M.E., Teitelman,G. The role of pregnancy hormones in the regulation of Pdx-1 expression. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2005; 233(-1-2-):1-13. >>> Prolactin, bovine; NaHCO3; SC; Mice; 2001; 4.5 days; Controls received mp w/ vehicle; functionality of mp verified by serum bPRL levels; peptides; multiple pumps per animal (2).

P7044 Auchtung,T.L., Dahl,G.E. Prolactin mediates photoperiodic immune enhancement: Effects of administration of exogenous prolactin on circulating concentrations, receptor expression, and immune function in steers. Biology of Reproduction 2004; 71(-6-):1913-1918. >>> Prolactin, recomb. bovine; Saline; SC; Cattle; 2ML2; 10 days; Comparison of IV injections vs mp; no stress ( see pg. 1914); immunology; peptides; post op. care (prodine, excenel); each animal received 4 rounds of 10 day prolactin treatment (2 w/ mp, 2 IV injection) with 11 days of non treatment between each round.

P7705 Combs,T.P., Berg,A.H., Rajala,M.W., Klebanov,S., Iyengar,P., Jimenez-Chillaron,J.C., Patti,M.E., Klein,S.L., Weinstein,R.S., Scherer,P.E. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003/2; 52(-2-):268-276. >>> Prolactin; bromocriptine; SC; Mice; 1007D; 3 days; Animal info (female, C57BL/6J).

P6603 Xu,X.L., Wu,W., Williams,V., Khong,A., Chen,Y.H., Deng,C.H., Walker,A.M. Opposite effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin on morphology and the expression of prostate specific genes in the normal rat prostate. PROSTATE 2003; 54(-1-):25-33. >>> Prolactin, human recomb.; prolactin, S179D; Saline; SC; Rat; 2004; 3 weeks; Comparison of SC injections vs. mp; peptides.

P5810 Hedlund,G.P., Carlsson,H.E., Shieck,E., Nilsson,I., Lundblad,C., Arons,S., Iversen,A.K., Looman,C., Jensen,H.E., Hau,J. Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland. In Vivo 2003; 17(-1-):1-4. >>> Prolactin; Saline; SC; Rat (pregnant); 2001; 2004; 7 days; peptides; unmodified (u-PRL)&phosphorylated (p-PRL) prolactin used.

P5677 Nahi,F., Arbogast,L.A. Prolactin modulates hypothalamic preproenkephalin, but not proopiomelanocortin, gene expression during lactation. Endocrine 2003; 20(-1-2-):115-122. >>> Prolactin, ovine; Sodium bicarbonate; heparin; NaCl; IV (jugular); Rat; ; Controls received mp w/ vehicle; half-life = 6 hours (p.119); peptides; heparin dose 50 U/ml.

P5460 Kuo,C.B., Wu,W., Xu,X.L., Yang,L.L., Chen,C., Coss,D., Birdsall,B., Nasseri,D., Walker,A.M. Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland. Cell and Tissue Research 2002; 309(-3-):429-437. >>> Prolactin, S179D; Saline; SC; Rat; 2001; 2004; 28 days.

P5410 Yang,L., Lii,S., Kuo,B., Buckley,A., Buckley,D., Chen,C., Xu,X.L., Coss,D., Walker,A.M. Maternal prolactin composition can permanently affect epidermal gamma delta T cell function in the offspring. Developmental and Comparative Immunology 2002; 26(-9-):849-860. >>> Prolactin, recomb; prolactin, phosphorylated; Saline; Rat (pregnant); 2002; ; Controls received mp w/ vehicle; teratology; peptides; apoptosis.

P5143 Torner,L., Toschi,N., Nava,G., Clapp,C., Neumann,I.D. Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses. European Journal of Neuroscience 2002; 15(--):1381-1389. >>> Oligodeoxynucleotide, antisense; Prolactin, ovine; Ringer's solution; CSF/CNS; Rat (lactating); 1007D; 5 days; controls received mp w/ vehicle; antisense; oligonucleotides against the long form of the brain Prolactin receptor.

P4954 Torner,L., Toschi,N., Pohlinger,A., Landgraf,R., Neumann,I.D. Anxiolytic and anti-stress effects of brain prolactin: Improved efficacy of antisense targeting of the prolactin receptor by molecular modeling. Journal of Neuroscience 2001; 21(-9-):3207-3214. >>> Prolactin; S179D; SC; mice (nude); 2004; 5 days; controls received mp w/ vehicle; functionality of mp verified by plasma prolactin levels; peptides; cancer (prostate); S179D is a prolactin receptor antagonist; wild-type prolactin used..

P5239 Sockman,K.W., Schwabl,H., Sharp,P.J. The role of prolactin in the regulation of clutch size and onset of incubation behavior in the American kestrel. Horm.Behav. 2000/11; 38(-3-):168-176. >>> Prolactin, ovine; NaCO3; NaCl; SC; Bird (kestrel); 1002; 15 days; Controls received mp w/ vehicle; prolactin plasma levels checked; dose-response (p.173); 17 min. half-life (p.171).

P3694 Wardlaw,S.L., Kim,J., Matera,C. Effect of chronic prolactin infusion on pituitary prolactin and hypothalamic proopiomelanocortin. J.Neuroendocrinology 1997; 9(--):81-85. >>> Prolactin, ovine; Phosphate buffer; SC; CSF/CNS (third ventricle); rat; 2001; 1 or 2 weeks; controls received mp w/ vehicle; ICV&SC pumps replaced after 7 days; peptides; solutions were millipore filtered; 1 sc mp replaced with 2 pumps after 7 days.

P6301 Payne,A.P., Shah,S.W., Marr,F.A., McGadey,J., Thompson,G.G., Moore,M.R. Hormones and the Control of Porphyrin Biosynthesis and Structure in the Hamster Harderian Gland. Microscopy Res.and Tech. 1996; 34(--):123-132. >>> Bromocriptine; prolactin; Hamster; ; Replacement therpay (castration, ovariectomy); multiple pumps per animal (2).

P3807 Hedner,E., Linde,A., Nilsson,A. Systemically and locally administered growth hormone stimulates bone healing in combination with osteopromotive membranes: an experimental study in rats. J.Bone and Min.Res. 1996; 11(-12-):1952-1960. >>> Growth hormone, bovine; Growth hormone, human; Prolactin, ovine; SC; bone (mandible); rat; 2, 3, 4 weeks; controls received mp w/saline; pumps replaced after 2 weeks; recomb. human and bovine GH used.

P3037 Myal,Y., Iwasiow,B., Yarmill,A., Harrison,E., Paterson,J.A., Shiu,R.P.C. Tissue-specific androgen-inhibited gene expression of a submaxillary gland protein, a rodent homolog of the human prolactin-inducible protein/GCDFP-15 gene. Endocrinology 1994; 135(-4-):1605-1610. >>> Prolactin, ovine; rat; 14 days; peptides.

P3008 Freyschuss,B., Sahlin,L., Masironi,B., Eriksson,H. The hormonal regulation of the oestrogen receptor in rat liver: an interplay involving growth hormone, thyroid hormones and glucocorticoids. J.Endocrinol. 1994; 142(--):285-298. >>> Growth hormone, human; Triiodothyronine, L-; Prolactin, ovine; Dexamethasone; SC; rat; 7 days; controls received hypophysectomy only w/ no mp; functionality of mp verified by checking pumps after usage; replacement therapy (hypophysectomy); comparison of single sc injections of GH&T3 vs. mp; agents given alone or in combination; growth hormone via mp partly restores liver estrogen receptor concentration while same dose in 2 single injections daily has no effect.

P2998 DiGregorio,G.B., Gonzalez Reyna,A., Murphy,B.D. Roles of melatonin and prolactin in testicular crudescence in mink (Mustela vison). J.Reprod.Fertil. 1994; 102(--):1-5. >>> Prolactin, ovine; SC; mink; 110 days; controls received no treatment; long-term study, pumps replaced every 4 weeks; peptides.

P2858 Pitts,G.R., Youngren,O.M., Silsby,J.L., Rozenboim,I., Chaiseha,Y., Phillips,R.E., Foster,D.N., El Halawani,M.E. Role of vasoactive intestinal peptide in the control of prolactin-induced turkey incubation behavior. II. Chronic infusion of vasoactive intestinal peptide. Biol.Reprod. 1994; 50(--):1350-1356. >>> Vasoactive intestinal peptide, porcine; Prolactin, ovine; Saline; Sodium bicarbonate; SC; CSF/CNS; CSF/CNS (median eminence); bird (turkey); 2001; 2002; 7, 10, 12 days; controls received mp with saline; functionality of mp verified by residual volume; stability of pVIP -- still potent after 17 days in sc pump; peptides; pumps implanted after recovery from CNS surgery.

P2591 Arbogast,L.A., Voogt,J.L. Pituitary adenylate cyclase-activating polypeptide (PACAP) increases prolactin release and tuberoinfundibular dopaminergic neuronal activity. Brain Research 1994; 655(--):17-24. >>> Prolactin, ovine; Sodium bicarbonate; Sodium chloride; Heparin; IV (jugular); rat; 2 days; functionality of mp verified by RIA of plasma levels; peptides; PACAP 38 or saline injections iv, concomitantly; 50 U/ml of heparin.

P2456 Katz,L.S., Nicoll,C.S. Evidence for a role of the liver in the luteotropic action of prolactin in rats. Biol.Reprod. 1993; 48(--):512-514. >>> Prolactin, ovine; Sodium azide; Sodium phosphate; Saline; Glycerol; IV (jugular); IV (hepatic portal); rat; 2002; no duration posted; pulsed delivery; peptides; air used in lynch coil.

P2422 Ruby,N.F., Nelson,R.J., Licht,P., Zucker,E. Prolactin and testosterone inhibit torpor in siberian hamsters. Am.J.Physiol. 1993; 264(-133-):R123-R128. >>> Prolactin, ovine; Glycerol; Sodium azide; Sodium heparin; PBS; SC; hamster; 2002; 10 days; controls received mp w/ vehicle solution; telemetry tracked temperature and activity.

P2312 Hebert,N.J., Kim,J.H., Lin,R.J., Nicoll,C.S. Restoration of lactation in bromocriptine-treated rats by prolactin replacement: comparison of constant versus pulsatile infusion and intrahepatic versus intrajugular routes of delivery. J.Endocrinol.Invest. 1993; 16(--):29-35. >>> Prolactin, ovine; IV (jugular); IV (hepatic portal); rat; 2001; 5 days; controls received mp w/ solvent; functionality of mp verified by in vitro dye testing of pulsatile release; comparison of pulsed delivery w/ mp vs. continuous infusion w/ mp; pulsed delivery; "Constant infusion of oPRL. . . was, overall, more effective at restoring lactation. . . than was giving pulses, regardless of the site of delivery." (pg. 29).

P2359 Meseguer,A., Catterall,J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol.and Cellular Endocrin. 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; 7 days; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

P2003 Liu,Y., Hyde,J.F., Vore,M. Prolactin regulates maternal bile secretory function post partum. J.Pharmacol.Exp.Ther. 1992; 261(-2-):560-566. >>> Prolactin; Glycerol; Sodium azide; Sodium carbonate; IV (jugular); rat; 2001; 6 days; dose-response (table p564).

P3106 Tsukamura,H., Maeda,K.-I., Ohkura,S., Uchida,E., Yokoyama,A. The suppressing effect of the suckling stimulus on the pulsatile luteinizing hormone release is not mediated by prolactin in the rat at mid-lactation. Jpn.J.Animal Reprod. 1991; 37(-1-):59-63. >>> Prolactin, ovine; Sodium bicarbonate; Saline; SC; rat; 2001; no duration posted; peptides.

P1889 Arbogast,L.A., Voogt,J.L. Hyperprolactinemia increases and hypoprolactinemia decreases tyrosine hydroxylase messenger ribonucleic acid levels in the arcuate nuclei, but not the substantia nigra or zona incerta. Endocrinology 1991; 128(-2-):997-1005. >>> Prolactin; Heparin; Sodium bicarbonate; Sodium chloride; IV (jugular); rat; 2001; 7 days; Animal info (SD, F, 175-225 g); 50 U/ml of heparin.

P1844 Youngren,O.M., El Halawani,M.E., Silsby,J.L., Phillips,R.E. Intracranial prolactin perfusion induces incubation behavior in turkey hens. Biol.Reprod. 1991; 44(-3-):425-431. >>> Prolactin, ovine; Ammonium bicarbonate; Saline; CSF/CNS; bird (turkey); 2ML4; 14 days; peptides.

P1758 Hebert,N.J., Kim,J.H., Nicoll,C.S. On the possible role of the liver in the galactopoietic action of prolactin in the rat. Endocrinology 1991; 128(-3-):1505-1510. >>> Prolactin, ovine; Glycerol; heparin, porcine sodium; sodium azide; IV (external jugular); IV (hepatic portal); rat; 2001; no duration posted; Functionality of mp verified by serum RIA; stability verified by incubation in pumps in vitro at 37 degrees celsius for 2 days, data given out to 6 days; 5 doses of prolactin infused; 250 U/ml porcine, sodium heparin used; animal info (Long-Evans, F).

R0089 Amkraut,A., Eckenhoff,J.B., Nichols,K. Osmotic delivery of peptides and macromolecules. Adv.Drug Delivery Review 1990; 4(--):255-276. >>> Atrial natriuretic factor; Cholecystokinin; Colony-stimulating factor, G.; Glucagon; Insulin; Interleukin-2; Interleukin-3; Melatonin; Nerve growth factor; Neurotensin; Prolactin; Theophylline; CSF/CNS; IA (femoral); intrasplenic; IP; SC; no duration posted; peptides; ALZA-authored, review of peptide delivery issues and applications; tissue perfusion (spleen).

P3271 Maeda K.-I., Uchida,E., Tsukamura,H., Ohkura,N., Ohkura,S., Yokoyama,A. Prolactin does not mediate the suppressive effect of the suckling stimulus on luteinizing hormone secretion in ovariectomized lactating rats. Endocrinol.Japan 1990; 37(-3-):405-411. >>> Prolactin, ovine; SC; rat; 2001; no duration posted; pumps replaced after 8 days; peptides.

P1832 English,D.E., Russell,S.M., Katz,L.S., Nicoll,C.S. Evidence for a role of the liver in the mammotrophic action of prolactin. Endocrinology 1990; 126(-5-):2252-2256. >>> Prolactin, ovine; Glycerol; Sodium azide; IV (jugular); IV (hepatic portal); rat; 2 weeks; pulse delivery; peptides.

P1589 Madon,R.J., Ensor,D.M., Flint,D.J. Hypoinsulinaemia in the lactating rat is caused by a decreased glycaemic stimulus to the pancreas. J.Endocrinol. 1990; 125(--):81-88. >>> Growth hormone, ovine; Prolactin, ovine; rat; 2001; 5 days; functionality of mp verified by serum levels; replacement therapy (oviarectomy) in some of the prolactin-treated animals.

P1834 Pedersen,H.C. Effects of exogenous prolactin on parental behaviour in free-living female willow ptarmigan lagopus l. lagopus. Anim.Behav. 1989; 38(--):926-934. >>> Prolactin; Sodium bicarbonate; SC; bird (ptarmigan); 2001; 6 days; pumps replaced after 6 days; flow calculated for birds' higher body temp. to be 1.15 ul/hr; peptides.

P1375 Oscarsson,J., Jansson,J.-O., Eden,S. Plasma pattern of growth hormone regulates sexual differentiation of phosphatidylcholine in rat plasma. Acta Physiol.Scand. 1988; 133(--):257-265. >>> Growth hormone, human; Prolactin, ovine; Saline; SC; rat; 2001; 7 days; controls received sham surgery; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1361 Brelje,T.C., Sorenson,R.L. Nutrient and hormonal regulation of the threshold of glucose-stimulated insulin secretion in isolated rat pancreases. Endocrinology 1988; 123(-3-):1582-1590. >>> Growth hormone, bovine; Prolactin, ovine; Glycerol; Sodium bicarbonate; Water; SC; rat; 2ML1; 4 days; functionality of mp verified by serum levels; peptides.

P1336 Oscarsson,J., Eden,S. Sex differences in fatty acid composition of rat liver phosphatidylcholine are regulated by the plasma pattern of growth hormone. Biochim.Biophys.Acta 1988; 959(--):280-287. >>> Growth hormone, bovine; Growth hormone, human; Prolactin, ovine; Glycerol; PBS; Saline; Sodium azide; Water; SC; rat; 2001; 6 days; comparison of sc injections 2x daily vs. mp infusion; replacement therapy (gonadectomy and hypophysectomy); peptides.

P1264 Kishi,K., Ogren,L., Southard,J.M., Talamantes,F. Pituitary factors regulating mouse placental lactogen-II secretion during the last half of pregnancy in mice. Endocrinology 1988; 122(-5-):2309-2317. >>> Growth hormone, murine; Prolactin, murine; Prolactin, bovine; Saline; SC; mice (pregnant); 2001; no duration posted; controls received mp w/saline; dose-response; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1422 Yamazoe,Y., Shimada,M., Murayama,N., Kato,R. Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J.Biol.Chem. 1987; 262(-15-):7423-7428. >>> Growth hormone, human; Prolactin, ovine; SC; rat; 2001; 7 days; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1151 Blanck,A., Hansson,T., Eriksson,L.C., Gustafsson,J.-A. Growth hormone modifies the growth rate of enzyme-altered hepatic foci in male rats treated according to the resistant hepatocyte model. Carcinogenesis 1987; 8(-11-):1585-1588. >>> Growth hormone, bovine; Prolactin, ovine; SC; rat; 2001; 2002; 7, 20 days; controls received mp sized tubing; concomitant infusion of agents; 2001 replaced w/ 2002 after 7 days; 2-AAF suppl.; peptides; cancer.

P1146 Sorenson,R.L., Johnson,M.G., Parsons,J.A., Sheridan,J.D. Decreased glucose stimulation threshold, enhanced insulin secretion, and increased beta cell coupling in islets of prolactin-treated rats. Pancreas 1987; 2(-3-):283-288. >>> Prolactin, ovine; Glycerol; Sodium bicarbonate; SC; rat; 2ML1; 4 days; controls received mp w/ vehicle; dose-response (text); functionality of mp verified; peptides.

P1005 Norstedt,G., Husman,B., Mode,A., Eneroth,P., Lewis,U.J., Gustafsson,J.-A. Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides. Acta Endocrinol. 1987; 114(--):350-356. >>> Prolactin, human; Growth hormone, bovine; Growth hormone, human; Growth hormone, rat; Lactogen, human placental; Prolactin, ovine; Prolactin, rat; 125I tracer; Saline; Sodium bicarbonate; Sodium carbonate; Tris buffer; SC; rat; 2001; 2ML1; 1 week; mp w/vehicle; peptides; replacement therapy (hypophysectomy).

P0981 Nilsson,A., Isgaard,J., Lindahl,A., Peterson,L., Isaksson,O. Effects of unilateral arterial infusion of GH and IGF-I on tibial longitudinal bone growth in hypophysectomized rats. Calcif.Tissue Int. 1987; 40(-2-):91-96. >>> Growth hormone, human; Insulin-like growth factor I; Prolactin, ovine; Saline, heparinized; IA (femoral); rat; 2002; 14 days; controls were untreated; mp connected to catheter in femoral artery; replacement therapy (hypophysectomy); local IA infusion; peptides.

P0949 Grosvenor,C.E., Shyr,S.W., Crowley,W.R. Effect of neonatal prolactin deficiency on prepubertal tuberoinfundibular and tuberohypophyseal dopaminergic neuronal activity. Endocrinol.Exp. 1986; 20(-2/3-):223-228. >>> Prolactin, ovine; Saline; SC; rat; 2001; 6 days; controls received mp w/saline; dose-response; peptides.

P0885 Shyr,S.W., Crowley,W.R., Grosvenor,C.E. Effect of neonatal prolactin deficiency on prepubertal tuberinfundibular and tuberohypophyseal dopaminergic neuronal activity. Endocrinology 1986; 119(-3-):1217-1221. >>> Prolactin, ovine; Saline; SC; rat; 2001; 2-5 days; controls received mp w/saline; teratology; pumps implanted on postpartum day 2; half of mp group received bromocriptine treatment also; peptides.

P0808 Joseph,J.A., Lippa,A.S. Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration II. non-stereotypic behaviors. Neurobiol.Aging 1986; 7(-1-):37-40. >>> Prolactin, rat; Saline; SC; rat; 2001; 7 days; peptides.

P0807 Joseph,J.A., Roth,G.S., Lippa,A.S. Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration I. rotational behavior. Neurobiol.Aging 1986; 7(-1-):31-35. >>> Prolactin, rat; Saline; SC; rat; 2001; 7 days; 6-OHDA lesions in left substantia nigra; peptides.

P0771 Schlechter,N.L., Russell,S.M., Greenberg,S., Spencer,E.M., Nicoll,C.S. A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion. Am.J.Physiol. 1986; 250(--):E231-E235. >>> Growth hormone, rat; Prolactin, ovine; Glycerol; Sodium azide; IA (superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); mp connected to catheter in superior vesicle artery; detailed description and diagram of catheter apparatus; constant and pulsed delivery of GH; peptides.

P0767 Mills,D.E., Ward,R.P. Effect of prolactin on blood pressure and cardiovascular responsiveness in the rat. Proc.Soc.Exp.Biol.Med. 1986; 181(--):3-8. >>> Prolactin, ovine; Saline; IP; rat; 2001; 7 days; dose-response (plasma levels); various doses af agent infused; oPRL half-life; peptides.

P0725 Jellinck,P.H., Quail,J.A., Crowley,C.A. Normal and recombinant human growth hormone administered by constant infusion feminize catechol estrogen formation by rat liver microsomes. Endocrinology 1985; 117(--):2274-2278. >>> Growth hormone, human; Prolactin; Saline; SC; rat; 2001; 5-7 days; peptides.

P0710 Mills,D.E., Woods,R.B. Interaction of prolactin with adrenal hormones in blood pressure regulation in rats. Am.J.Physiol. 1985; 249(--):E614-E618. >>> Corticosterone; Epinephrine; Norepinephrine; Prolactin, ovine; Ethanol; Sodium chloride; Water; IP; rat; 2001; 7 days; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents; multiple pumps per animal (2) for CORT; hypertension; controls received mp w/NaCl; peptides.

P0688 MacGeoch,C., Morgan,E.T., Gustafsson,J.-A. Hypothalamo-pituitary regulation of cytochrome P-450(15B) apoprotein levels in rat liver. Endocrinology 1985; 117(-5-):2085-2092. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; SC; rat; 2001; 2ML1; 1 week; comparison of twice daily sc injec of rat GH vs. mp infusion; replacement therapy (hyposphysectomy); controls received sham mp made of silicone; tubing; peptides.

P0667 Dembinski,T.C., Leung,C.K.H., Shiu,R.P.C. Evidence for a novel pituitary factor that potentiates the mitogenic effect of estrogen in human breast cancer cells. Cancer Res. 1985; 45(-7-):3083-3089. >>> Growth hormone, human; Growth hormone, ovine; Prolactin, ovine; mice; 49-56 days; comparison of daily sc injec. vs. mp infusion; comparison of agents effects; long-term study; cancer; peptides.

P0639 Mick,C.C.W., Nicoll,C.S. Prolactin directly stimulates the liver in vivo to secrete a factor (synlactin) which acts synergistically with the hormone. Endocrinology 1985; 116(-5-):2049-2053. >>> Growth hormone, ovine; Prolactin, ovine; Citric acid; Glycerol; IV (hepatic portal); IV (jugular); bird (pigeon); 2001; 1 week; comparison of agents effects; citric acid added to solvent for bacteriostatic effects; pulsed delivery of hormone or solvent (intermittent w/ air); peptides; tissue perfusion.

P0573 Morgan,D.G., Mobbs,C.V., Anderson,C.P., Sinha,Y.N., Finch,C.E. Hyperprolactinemia fails to increase striatal dopamine receptors in male and female C57BL/6J mice. Eur.J.Pharmacol. 1984; 107(-1-):101-104. >>> Prolactin, ovine; Saline; SC; mice; 2001; 1 week; comparison of homotypic anterior pituitary grafts vs. mp prolactin infusion; dose-response data; peptides.

P0535 Baxter,R.C., Zaltsman,Z. Induction of hepatic receptors for growth hormone (GH) and prolactin by GH infusion is sex independent. Endocrinology 1984; 115(-5-):2009-2014. >>> Growth hormone, rat; Prolactin, rat; SC; rat; 1 week; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0460 Haaparanta,T., Glaumann,H., Gustafsson,J.-A. Characterization and endocrine regulation of the cytochrome P-450 dependent microsomal hydroxylation of 5a-androstane-3B,17B-diol in the rat ventral prostate. Endocrinology 1984; 114(-6-):2293-2300. >>> Growth hormone, human; Prolactin, ovine; Sodium hydroxide; Saline; SC; rat; 2001; 1 week; vehicle used w/PRL was saline&NaOH; saline used alone as vehicle w/hGH; peptides.

P0450 Baxter,R.C., Zaltsman,Z., Turtle,J.R. Rat growth hormone (GH) but not prolactin (PRL) induces both GH and PRL receptors in female rat liver. Endocrinology 1984; 114(-5-):1893-1901. >>> Growth hormone, ovine; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; comparison of agents effects; peptides.

P0329 Levin,P., Haji,M., Joseph,J.A., Roth,G.S. Effect of aging on prolactin regulation of rat striatal dopamine receptor concentrations. Life Sci. 1983; 32(--):1743-1749. >>> Prolactin, rat; Saline; SC; rat; 2001; 1 week; peptides.

P0322 Ewing,L.L., Wing,T.-Y., Cochran,R.C., Kromann,N., Zirkin,B.R. Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 1983; 112(-5-):1763-1769. >>> Follicle stimulating hormone; Growth hormone, ovine; Luteinizing hormone; Prolactin, ovine; Thyroid-stimulating hormone; Borate; Peanut oil; SC; rat; 5 days; replacement therapy (hypophysectomy); simultaneous infusion of testosterone&estradiol implants w/ mp infusion of polypeptides; pulsed delivery of agents (intermittent w/ vehicle); peptides; ovine LH used.

P0318 Herbert,J., Martensz,N.D. The effects of intraventricular prolactin infusions on pituitary responsiveness to thyrotropin-releasing hormone, 5-hydroxytryptophan or morphine in rhesus monkeys. Brain Research 1983; 258(--):251-262. >>> Prolactin, ovine; Albumin, bovine serum; CSF/CNS; monkey; 2ML1; 6 days; comparison of injec. vs mp infusion; peptides.

P0330 Hruska,R.E., Pitman,K.T., Silbergeld,E.K., Ludmer,L.M. Prolactin increases the density of striatal dopamine receptors in normal and hypophysectomized male rats. Life Sci. 1982; 30(--):547-553. >>> Prolactin, ovine; Saline; SC; rat; 7-8 days; comparison of injec vs. mp infusion; peptides.

P0230 Skett,P., Young,C. The effects of pituitary hormones on hepatic drug metabolism in the rat. Acta Endocrinol. 1982; 100(--):421-426. >>> Follitropin, rat; Thyrotropin, rat; Growth hormone, human; Growth hormone, rat; Pituitary extract; Prolactin, rat; Saline; Water; SC; rat; 1701; 6 days; organ replacement therapy (hypophysectomy); agents also injected - comparison of injec vs. mp infusion; peptides.

P0215 Norstedt,G. A comparison between the effects of growth hormone on prolactin receptors and estrogen receptors in rat liver. Endocrinology 1982; 110(-6-):2107-2112. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; organ replacement therapy (hypophysectomy); intermittent injections vs. infusion; peptides.

P0212 Pousette,A., Bjork,P., Carlstrom,K., Forsgren,B., Hogberg,B., Gustafsson,J.-A. Influence of pituitary and adrenocortical hormones on prostatic secretion protein, a major protein in rat prostate. The Prostate 1982; 3(--):109-114. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 2 weeks; replacement therapy (hypophysectomy); peptides.

P0168 Mills,D.E., Buckman,M.T., Peake,G.T. Effects of prolactin administration and suppression on blood pressure and body fluid compartments in the rat. Endocrinology 1981; 109(-5-):1590-1596. >>> Lergotrile mesylate; Prolactin, ovine; Vasopressin, 1-desamino-8-D arginine; Saline; IP; rat; no duration posted; Exp. 1-3, 1701, 7 days: 1)saline, oPRL,&LM&oPRL simultaneously; 2&3)saline, oPRL, Vasopressin, 1-desamino-8-D arginine; 4) 2001, 7 days, saline, oPRL; peptides.

P0155 Shafie,S.M., Grantham,F.H  J.Natl.Cancer Inst. 1981; 67(-1-):51-56. >>> Prolactin, ovine; Saline; IP; mice (nude); no duration posted; replacement therapy (hypophysectomy); cancer; peptides.

P0148 Gustafsson,J.-A., Eneroth,P., Hokfelt,T., Mode,A., Norstedt,G., Skett,P. Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents. Environ.Health Perspect. 1981; 38(--):129-141. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; SC; rat; 7 days; replacement therapy (hypophysectomy); toxicology; peptides.

P0133 Mode,A., Norstedt,G., Simic,B., Eneroth,P., Gustafsson,J.-A. Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat. Endocrinology 1981; 108(-6-):2103-2108. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P0126 Norstedt,G., Mode,A., Eneroth,P., Gustafsson,J.-A. Induction of prolactin receptors in rat liver after the administration of growth hormone. Endocrinology 1981; 108(-5-):1855-1861. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P0118 Norstedt,G., Wrange,O., Gustafsson,J.-A. Multihormonal regulation of the estrogen receptor in rat liver. Endocrinology 1981; 108(-4-):1190-1196. >>> Growth hormone, bovine; Prolactin, bovine; Prolactin, ovine; Sodium hydroxide; Saline; SC; rat; 7 days; comparison of agents; organ replacement therapy (hypophysectomy); separate infusion of all hormones&simultaneous infusion of oPRL&bGH (2 pumps/animal); peptides.

R0046 Skett,P., Young,C. The effect of pituitary hormones on hepatic drug metabolism. In 'Biochemistry, Biophysics and Regulation of Cytochrome P-450,' J.-A.Gustafsson, J.Carlstedt-Duke, A.Mode, and J.Rafter (eds.), Elsevier/North-Holland, Amsterdam 1980; (--):195-198. >>> Enkephalin analog DADLE; Follicle stimulating hormone; Growth hormone, bovine; Growth hormone, rat; Pituitary extract; Prolactin, bovine; Prolactin, rat; Thyroid-stimulating hormone; Water; SC; rat; 1701; 1 week; peptides.

P0071 Murphy,B.D., Humphrey,W.D., Shepstone,S.L. Luteal function in mink: the effects of hypophysectomy after the preimplantation rise in progesterone. Anim.Reprod.Sci. 1980; 3(--):225-232. >>> Luteinizing hormone; Prolactin, bovine; Saline; IP; mink; 7 days; organ replacement therapy (hypophysectomy); peptides; ovine LH used.

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