References on Using ALZET^® Osmotic Pumps In Space

P4282 Adams,G.R., McCue,S.A., Bodell,P.W., Zeng,M., Baldwin,K.M. Effects of spaceflight and thyroid deficiency on hindlimb development. I. Muscle mass and IGF-I expression. J.Appl.Physiol. 2000; 88(--):894-903. >>> Propylthiouracil; IP; Rat (lactating); 2ML4; 16 days; Teratology; Propythiouracil was delivered to neonates via dam's milk; pilot studies showed that this resulted in similar depression in plasma T3 and T4 to direct PTU injection to neonates; Propylthiouracil is an antihyperthyroid that blocks the conversion of L-thyroxine T4 to T3; spaceflight.

P4138 Turner,R.T. Effects of short-term spaceflight and recombinant human growth hormone (rhGH) on bone growth in young rats. Aviation Space Environ Med 1995; 66(--):763-769. >>> Growth hormone, recomb. human; Phosphate; F68 detergent; SC; rat; 5 days; controls received mp w/vehicle; peptides; spaceflight.

P3604 Lorenzi,G., Gmunder,F.K., Cogoli,A. Cultivation of hamster kidney cells in a dynamic cell culture system in space (spacelab IML-1 mission). Microgravity Sci.Technol. 1993; VI/1(--):34-38. >>> NaHCO3; Glucose; HEPES; DMEM; Serum, fetal calf; Gentamicin; in vitro (cell culture); 2001; no duration posted; mp connected to cell culture chamber; "...the osmotic pump delivered sufficient fresh medium to support cell growth in the perfusion chambers." p. 37; spaceflight.

P3289 Jiang,B., Roy,R.R., Navarro,C., Edgerton,V.R. Absence of a growth hormone effect on rat soleus atrophy during a 4-day spaceflight. Am.Physiol.Soc. 1993; 74(-2-):527-531. >>> Growth hormone, recomb. human; Phosphate; F-68; SC; rat; 4 days; controls received mp w/ vehicle; functionality of mp verified by immunoassay; stability verified by HPLC; musculoskel; spaceflight.

P2163 Cronin,M., Battersby,J., Hancock,W., Schwall,T., Clark,R. Delivery of recombinant human growth hormone to rats during exposure to microgravity on NASA space shuttle discovery. Physiologist 1992; 35(-1-):S51-S52. >>> Growth hormone, recomb. human; F68 detergent; Phosphate; SC; rat; 5 days; functionality of mp verified upon removal by immunoassay; peptides; mp performed well in microgravity; spaceflight.

P4504 Rasmussen,O, Gmünder,F, Tairbekov,M, Kordyum,E.L, Lozovaya,V.V, Baggerud,C, Iversen,T.-H  ESA 1990/11; 307(--):527-530. >>> Growth medium; In vitro; 14 days; mp used to deliver growth medium to protoplasts during spaceflight.

P3948 Gmunder,F.K., Suter,R.N., Kiess,M., Urfer,R., Nordau,C.-G., Cogoli,A. Mammalian cell cultivation in space. Adv.Space Res 1989; 9(-11-):119-127. >>> Culture media; Glucose; Fetal calf serum; HEPES buffer; Gentamycin;; in vitro (cell culture); 2001; 2002; ; diagram of dynamic cell culture system on page 123; in vitro; spaceflight.

P1382 Gmunder,F.K., Nordau,C.-G., Tschopp,A., Huber,B., Cogoli,A. Dynamic cell culture system: a new cell cultivation instrument for biological experiments in space. J.Biotechnol. 1988; 7(--):217-228. >>> Culture media, DMEM; HEPES; Serum, fetal calf; Gentamicin; Glucose; in vitro (cell culture); 2001; 7 days; Mp connected to cell culture chamber; cytotoxicity described; spaceflight.

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