Endocrine Research using ALZET^® Osmotic Pumps

The study of the action of hormones, hormone analogs, growth factors, and neuropeptides in animal models remains a critical avenue of basic and preclinical research. Continuous, controlled compound administration via ALZET osmotic pumps permits physiological concentrations to be achieved, despite the poor bioavailability or short half-life often associated with such agents. The ability to maintain a continuous presence of a compound is extremely beneficial when determining its effect on physiological response or in replacing the endogenous compound in a hormone deficient model. ALZET pumps have proven to be a useful tool for reliable, long-term delivery of agents while avoiding the stress-related complications induced by repeated handling inherent in frequent dosing schedules.

A wide variety of endocrine substances have been delivered using ALZET pumps. Examples of this work are contained in the following reference lists:

Some of these bibliographies may be large and take a short while to display. These bibliographies are updated frequently. As the references are listed most recent first, you may wish to truncate your printing to ten pages or less.

Antibodies

Aldosterone

Antihypertensive Agents

Cytokines

Dexamethasone

Deoxycorticosterone

Diabetes Research

Estrogens

Follicle Stimulating Hormone

Glucocorticoids

Growth Factors

Growth Hormone

Hormone Replacement (studies where exogenous hormone effects were determined in the absence of endogenous hormone production)

Insulin

Leptin

LH & LHRH

Nitric Oxide Research

Obesity Research

Parathyroid Hormone

Progesterone

Prolactin

Targeted Delivery

Testosterone

Vasopressin

If you are interested in a specific agent and did not find it listed above, check the index by Agent Administered.