“Insofar as multiple dosing is concerned, we propose that only administration by pump (or administration more than four times a day) can provide clinical-like occupancies for haloperidol, olanzapine, and risperidone.” Kapur et al., The Journal of Pharmacology and Experimental Therapeutics 2003;305:625-631.

News

ALZET Promotions

Below is a list of previous ALZET promotions and names for the corresponding winners. Congratulations to the lucky winners, and thank you to all scientists who participated in these special ALZET promotions:

ALZET Pharmacology Newsletter Announcement 2009: The winner of the iPod is Mary Beth Moreno

ALZET Bibliography Update Mailer 2008: The winner of the iPod is Dr. John Salig

The Endocrine Society's 90th Annual Meeting 2008: The winner of the iPod is Dr. Rishita Tiwari from Baystate Medical College

American Association for Cancer Research 2008: The winner of the iPod is Dr. Nalin S. Siriwardhana

Experimental Biology 2008: The winner of the iPod is Dr. Philip R. Brauer from Creighton University School of Medicine

Society for Toxicology 2008: The winner of the iPod is Dr. Michael C. Savides from Ricerca Biosciences

Product News

ALZET introduces new pump model (2006)

Available Now

Model 2006 Nominal Specifications:

  • Volume: 200 µl
  • Release rate: 0.15 µl/hour
  • Duration: 6 weeks

Key features:

  • Longest duration pump in any size, ideal for chronic studies in mice, rats, and other animal models
  • Low flow rate, ideal for tissue perfusion

 

ALZET introduces new pump model (1004)

Model 1004 Nominal Specifications:

  • Volume: 100 µl
  • Release rate: 0.11 µl/hour
  • Duration: 4 weeks

Key features:

  • Longest duration pump in 100 µl size; ideal for chronic studies in small mice and young rats
  • Slowest flow rate in ALZET product line, ideal for tissue perfusion

ALZET Osmotic Pumps Celebrate 30 Years of Continuous Delivery

Introduced in 1977, this year marks 30 years since the first ALZET Osmotic Pump was sold.  Over the last three decades the ALZET pumps have been proven as an integral research tool, allowing for the continuous delivery of test compounds. 

 

ALZET introduces three new specialized catheters.

These catheters are fully compatible with the ALZET Osmotic Pumps and are constructed from biocompatible materials. See more information on our catheter page.  The various models include the following:

    • Rat Intrathecal Catheter - Short
    • Mouse Jugular - Adjustable Length
    • Mouse Jugular - Adjustable Length/Large Tip

 

Company News

6/10/2008

Pain Therapeutics and King Pharmaceuticals Announce Submission of New Drug Application for Remoxy. Remoxy and other opioid painkillers developed under this alliance are unique formulations of the patented Oradur technology licensed from Durect Corporation.

7/17/2007

DURECT Reports Positive Results from POSIDUR(TM) Phase IIb Hernia Trial, Triggering $8 million Milestone Payment from Nycomed

Read More

 

Archive

 

Latest Research Using ALZET Pumps

Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study. Childs Nerv Syst 2009; 25(1):21-28. Thomale U et al.

Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem 2008; 283(23):15845-15852. Wang HY et al.
Pub Med Link

Steroid hormones act transsynaptically within the Forebrain to regulate neuronal phenotype and song stereotypy. JOURNAL OF NEUROSCIENCE 2007; 27(44):12045-12057. >>> Meitzen J, et al.
PubMed Link

Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Cancer Letters 2007; 247(1):143-149. >>> Zhang X, Connolly C, et al. "Continuous administration of 3TSR reduced dosage and improved therapeutic potency."

PubMed Link

Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase. J Med Chem 2007. >>> Mortlock AA, Foote KM, Heron NM, Jung FH, Pasquet G, Lohmann JJ et al.


Evaluation of an osmotic pump for microdialysis sampling in an awake and untethered rat. J Neurosci Methods 2007; 160(2):269-275. >>> Cooper JD, Heppert KE, Davies MI, Lunte SM. "the osmotic pump can be an invaluable improvement over the syringe pump.".

PubMed Link

 

 

 

 

 

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