Rates & Durations

There are 12 models of ALZET Osmotic Pumps in 3 physical sizes, and a variety of release rates and durations (*Note that nominal performance data is listed below. Individual lots of pumps will vary from this target within limits. The specific data for each lot of pumps should be used for dose calculations).

Dimensions, Components & Materials

The tables below review the specifications, dimensions and materials of ALZET osmotic pumps.ALZET Pumps

ALZET Pump Models    
Note: All items are supplied sterile. Pumps cannot be reused.  
Model Numbers 1003D, 1007D, 1002, 1004 2001D, 2001, 2002, 2004, 2006 2ML1, 2ML2, 2ML4
Reservoir Volume 100 µl 200 µl 2 ml
Complete Osmotic Pump
Length (cm) 1.5 3.0 5.1
Diameter (cm) 0.6 0.7 1.4
Weight (g) 0.4 1.1 5.1
Total Displaced Volume (ml) 0.5 1.0 6.5
Filling Tube
Length (cm) 1.1 2.2 3.5
Gauge 27 27 25
O.D. (cm) 0.04 0.04 0.05
I.D. (cm) 0.02 0.02 0.03
Flow Moderator
Length (cm) 1.3 2.4 4.6
Gauge 21 21 21
O.D. (cm) 0.08 0.08 0.08
I.D. (cm) 0.05 0.05 0.05
Weight (g) 0.05 0.2 0.9
Material (flange)
Styrene Acrylonitrile
Material (cap) n/a Polyethylene Polyethylene
Material (tube)
Stainless Steel 304
(non-metal alternatives)
Pump Body Materials
Outer Membrane
Cellulose Ester Blend
Drug Reservoir
Thermoplastic Hydrocarbon Elastomer

ALZET pumps are supplied in multiples of 10. Every 10 pumps comes with the following:

  • 10 Flow Moderators
  • 1 Filling Tube
  • 1 Instruction Sheet
*Lot Specific Performance Data:

The nominal performance is a target for all pumps manufactured. Individual lots of pumps may vary from this target within limits. The actual pumping rate and fill volume of a particular lot (derived by statistical testing) are listed on the top of the instruction sheet included with the pumps. The lot specific data should always be used when making dose calculations. If using pumps from different lots, the drug concentration for each lot of pumps should be adjusted to reflect the actual release rate. To inquire about a specific lot number, or if you have specific questions, please contact technical support at 1-800-692-2990.

Pump Advantages

  • Ensure around-the-clock exposure to test agents at predictable levels
  • Permit continuous administration of short half-life proteins and peptides
  • Provide a convenient method for the chronic dosing of laboratory animals
  • Minimize unwanted experimental variables and ensure reproducible, consistent results
  • Eliminate the need for nighttime or weekend dosing
  • Reduce handling and stress to laboratory animals
  • Small enough for use in mice or very young rats
  • Allow for targeted delivery of agents to virtually any tissue
  • Cost-effective research tool


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Researchers are saying...

“We found recently that 21 d of treatment of rats with SSRIs, at clinically relevant and stable serum concentrations (achieved by the use of osmotic minipumps), caused robust downregulation of the SERT.”... “Studies on the effects of chronic antidepressants on the SERT have resulted in inconsistent reports (Owens and Nemeroff, 1998). Among the factors that may contribute to such inconsistency is the route of drug administration. In most studies of chronic administration of Ads to rats, the drugs are given intraperitoneally or subcutaneously, either once or twice daily. As rats metabolize these drugs more rapidly than humans, such dosage schedules can result in appreciable fluctuations in the serum concentration of drug throughout the day. For certain pharmacologic effects, sustained drug action may be needed” Benmansour et al. The Journal of Neuroscience 2002; 22(15):6766-6772.