ALZET Catheters

Via a catheter, ALZET® Osmotic Pumps can deliver substances into vessels, spinal cord, cerebral ventricles and brain parenchyma, and other organs or tissues. DURECT Corporation offers a range of specialized catheters, compatible with ALZET pumps, to enable targeted delivery to a variety of sites. ALZET pumps can be attached to catheter tubing with I.D ranging from 0.58 mm to 0.76 mm (0.023"-0.030"). Click here for information about compatibility of ALZET specialized catheters with various solutions/vehicles.

Polyethylene (PE) and Vinyl Tubing

Medical grade PE and Vinyl tubing, the most common catheter types used in laboratory animal research, are available sterile, individually packaged, and ready to use.

Features

  • Sterile
  • Medical grade
  • Pre-cut to 15 cm lengths
  • Individually packaged
  • Ready to use
  • Fit all pump models

PE and Vinyl Tubing Specifications

Description

Order No.

Length

Outside Diameter

Inside Diameter

Volume

Vinyl Tubing
(10 per bag)

0007760

15cm
(6 in)

1.14 mm
(0.045 in)

0.69 mm
(0.027 in)

3.739 µl/cm

Polyethylene
(10 per bag)

0007750

15cm
(6 in)

1.22 mm
(0.048 in)

0.76 mm
(0.030 in)

4.566 µl/cm

Specialized Catheters*

 

Rat Jugular Catheter

 

Order No.: 0007710

Catheter Material: Silicone

Specifications:

15.24 cm (6") of silicone catheter (0.94 OD; 0.51 mm ID) with a Dacron suture patch and ALZET connection (1.19 mm OD; 0.61 mm ID). (Internal catehter volume is ~32-36 ul).

Optimum Animal Size:

250+ grams (for <250 gram rats, cut tip to size for proper placement)

Features & Benefits:

  • Dacron patch facilitates anchoring to tissue
  • Silicone material is very flexible and less traumatic to vessels
  • Bevel tip if desired for easier insertion into vessels
  • ETO sterilized

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Rat Femoral Catheter

 

Order No.: 0007720

Catheter Material: Polyurethane (PU)

Specifications:

20.32 cm (8") of Polyurethane catheter (1.02 mm OD; 0.61 mm ID); designed for intravenous cannulation. (Internal catehter volume is ~59 ul).

Optimum Animal Size:

Up to 300+ grams (for <175 gram rats, cut tip to size for proper placement)

Features & Benefits:

  • Retention beads at 3.81, 5.08, and 7.62 cm from the tip facilitate anchoring to tissue
  • Medical grade polyurethane softens at body temperature
  • Fits directly to pump (no step-up needed)

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Rat Femoral Catheter (Tapered)

Order No.: 0007730 (custom order)

Catheter Material: Opaque Polyurethane

Specifications:

20.32 cm (8") of tapered radio-opaque polyurethane (1.40 mm to 0.99 mm OD; 0.61 mm constant ID); designed for intravenous cannulation. (Internal catehter volume is ~59 ul).

Optimum Animal Size:

Up to 300+ grams (for <175 gram rats, cut tip to size for proper placement)

Features & Benefits:

  • Retention beads at 3.81, 5.08, and 7.62 cm from the tip facilitate anchoring to tissue
  • Medical grade, tapered polyurethane minimizes kinking
  • Radio-opaque material and smooth surface minimize clotting
  • Lumen maintains consistent ID, so that the catheter can be shortened without compromising its tight fit onto pump

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Rat Intrathecal Catheter

 

Order No.: 0007740

Catheter Material: Polyurethane (PU)

Specifications:

10 cm of 28G PU (0.36 mm OD; 0.18 mm ID) connected to 12.7 cm PU (0.84 mm OD; 0.36 mm ID) and ALZET connection (1.02 mm OD; 0.61 mm ID) with Teflon coated stylet wire. Total catheter length is 23.7 cm (9.33"). (Internal catehter volume is ~20 ul).

Optimum Animal Size:

Up to 300+ grams (cut distal end to desired length for proper placement)

Features & Benefits:

  • Designed for occipital insertion
  • Includes a Teflon coated stylet for easier placement
  • Protected tubing junction minimizes kinking at exit point from intrathecal space

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Rat Intrathecal Catheter (Short)

 

Order No.: 0007741

Catheter Material: Polyurethane (PU)

Specifications:

10 cm of 28G PU (0.36 mm OD; 0.18 mm ID) connected to 4.0 cm PU (0.84 mm OD; 0.36 mm ID) and ALZET connection (1.02 mm OD; 0.61 mm ID) with Teflon coated stylet wire. Total catheter length is 15.0 cm (5.90"). (Internal catehter volume is ~10-11 ul).

Optimum Animal Size:

Up to 300+ grams (cut distal end to desired length for proper placement)

Features & Benefits:

  • Shorter length for lumbar insertion
  • Includes a Teflon coated stylet for easier placement
  • Protected tubing junction minimizes kinking at exit point from intrathecal space

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Rat Intraperitoneal Catheter

 

Order No.: 0007770

Catheter Material: Silicone and Polyurethane (PU)

Specifications:

5.0 cm of Silicone (0.94 mm OD; 0.51 mm ID) connected to 3.0 cm PU (1.02 mm OD; 0.61 mm ID). Fenestrations over first 1.5 cm Silicone tip. Total catheter length is 8.0 cm. (Internal volume is ~19 ul).

Applications:

  • Peritoneal/Gastric delivery
  • Peritoneal delivery via subcutaneous pump
  • Easier pump replacement
  • Use larger SC pump for IP delivery in small rats

Features & Benefits:

  • Fenestrations over Silicone tip for greater drug distribution
  • Movable suture bead for optimum adjustment of inserted catheter section
  • Flexible Silicone section minimizes tissue trauma
  • Polyethylene section provides optimum fit to all ALZET pump models; can be cut to desired length
  • Stress relief catheter junction prevents kinking and improves patency

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Mouse Jugular Catheter

 

Order No.: 0007700

Catheter Material: Polyurethane (PU)

Specifications:

13mm of 28G PU (0.36 mm OD; 0.18 mm ID) connected to 63.5 mm PU (0.84 mm OD; 0.36 mm ID) and ALZET connection (1.02 mm OD; 0.61 mm ID). Total catheter length is 8.8 cm (3.46"). (Internal catehter volume is ~10 ul).

Optimum Animal Size:

30+ grams (insertion marks for adaptation to smaller animals)

Features & Benefits:

  • Retention beads at 13 and 38 mm from the tip facilitate anchoring to tissue
  • Catheter tip optimum for use with other small vessels (e.g., femoral, carotid, etc.)
  • Marked at 9 and 11 mm to simplify adaptation for <25 and 25-30 gram animals respectively

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Mouse Jugular Catheter (Adjustable Length)

Order No.: 0007701

Catheter Material: Polyurethane (PU)

Specifications:

13mm of 28G PU (0.36 mm OD; 0.18 mm ID) connected to 25.4 mm PU (0.84 mm OD; 0.36 mm ID) connected to a 50 mm ALZET connection (1.02 mm OD; 0.61 mm ID). Total catheter length is 8.8 cm (3.46"). (Internal catehter volume is ~18 ul).

Optimum Animal Size:

30+ grams (insertion marks for adaptation to smaller animals)

Features & Benefits:

  • ALZET connection can be trimmed to achieve smaller lengths
  • Catheter tip optimum for use with other small vessels (e.g., femoral, carotid, etc.)
  • Retention beads at 13 and 35 mm from the tip facilitate anchoring to tissue
  • Marked at 9 and 11 mm to simplify adaptation for <25 and 25-30 gram animals respectively

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Mouse Jugular Catheter (Adjustable Length-Large Tip)

Order No.: 0007702

Catheter Material: Polyurethane (PU)

Specifications:

44.5 mm of 20G PU (0.84 mm OD; 0.36 mm ID) connected to a 50 mm ALZET connection (1.02 mm OD; 0.61 mm ID). Total catheter length is 9.5 cm (3.74"). (Internal catehter volume is ~20 ul).

Optimum Animal Size:

30+ grams (insertion marks for adaptation to smaller animals)

Features & Benefits:

  • ALZET connection can be trimmed to achieve smaller lengths
  • Catheter tip optimum for jugular cannulation
  • Retention beads at 13 and 35 mm from the tip facilitate anchoring to tissue
  • Marked at 9 and 11 mm to simplify adaptation for <25 and 25-30 gram animals respectively

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Mouse Intrathecal Catheter

Order No.: 0007743

Catheter Material: Polyurethane

Specifications:

2.5 cm 32G (0.23 mm OD; 0.09 mm ID) connected to 1 cm (0.76 mm OD; 0.38 mm ID), connected to a 2.5 cm (1.02 mm OD; 0.61 mm ID) ALZET connection with Teflon coated stylet wire. Total catheter length is 6cm (2.36"). (Internal catehter volume is ~8.6 ul).

Optimum Animal Size:

Adult mouse

Features & Benefits:

  • Distal end can be trimmed
  • Includes a Teflon coated stylet for easier placement
  • Catheter is provided sterile

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Mouse Intraperitoneal Catheter

Order No.: 0007771

Catheter Material: Silicone and Polyurethane (PU)

Specifications:

3.0 cm of Silicone (0.94 mm OD; 0.51 mm ID) connected to 3.0 cm PU (1.02 mm OD; 0.61 mm ID). Fenestrations over first 1.0 cm Silicone tip. Total catheter length is 6.0 cm. (Internal volume is ~15 ul).

Applications:

  • Peritoneal/Gastric delivery
  • Peritoneal delivery via subcutaneous pump
  • Easier pump replacement
  • Use larger pump for IP delivery in mice

Features & Benefits:

  • Fenestrations over Silicone tip for greater drug distribution
  • Movable suture bead for optimum adjustment of inserted catheter section
  • Flexible Silicone section minimizes tissue trauma
  • Polyethylene section provides optimum fit to all ALZET pump models; can be cut to desired length
  • Stress relief catheter junction prevents kinking and improves patency

*All specialized catheters are supplied sterile (ETO sterilized)

 

Custom catheters require a two week lead time, with a minimum order of five catheters + setup fee.
Contact us for pricing and ordering information.

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Catheter applications with ALZET Osmotic Pumps

  • Direct delivery of test agents pecisely into any target tissue or organ
  • Delay administration of test agents to allow for a surgical recovery period
  • Infuse for a short period using a longer duration pump
  • Create a time-patterned delivery of an agent

Note: No catheter is necessary when systemic delivery is desired. This is accomplished by subcutaneous or intraperitoneal implantation of an ALZET pump without a catheter.

Common Routes of Administration Requiring Use of a Catheter

  • Articular cavity
  • Blood vessels
  • Bone
  • Brain (solid tissue)
  • Brain (ventricles)
  • Ear
  • Eye
  • Muscle
  • Nerves
  • Spinal cord
  • Stomach
  • Tumors