Loctite 454

Loctite 454 (item # 0008670) is an instant adhesive gel for use with ALZET® Brain Infusion Kits and other brain infusion cannulae. It offers a convenient alternative to cranioplastic dental cements. A very thin layer on the base of the pedestal adheres the cannula to the skull. Researchers have found it to be ideal for use in mice and other small animals when using short pedestal cannulae.

image of Loctite 454 with ALZET pumps

Product Description & Applications

  • No mix, instant adhesive gel for use with ALZET ® Brain Infusion Kits and other brain infusion cannulae
  • One 3 gram tube is enough for >10 brain infusion cannulae implantations
  • A convenient alternative to cranioplastic / dental cement
  • A very thin layer on the base of the pedestal adheres the cannula to the dry skull
  • Ideal for use in mice and other small animals when using short pedestal cannulae
  • Application technical tip

 

Advantages of Cyanoacrylate Gel Over Dental Cement

Significant time savings for the researcher

  • Studies indicate a substantial reduction in surgical time compared to the dental cement technique *
  • Comes ready to use; no need to mix during surgery

Significant animal welfare benefit *

  • Less stress to the experimental animal
  • Reduced time under anesthesia
  • Less adhesive material needed, thereby less overall implant size and weight on the animals
  • Easier to close the skin over the cannula
  • Minimal heat generated during curing
  • Less trauma to animals since fewer (or no) screws required to stabilize the cannula

 

 

Resources

* Criado, A. et al . Use of cyanoacrylate gel as a substitute for dental cement in intracerebroventricular cannulations in rats. Contemporary Topics 2003; 42(3):13-16.