ALZET pumps operate by osmotic displacement. An empty reservoir within the core of the pump is filled with the drug or hormone solution to be delivered.

Due to the presence of a high concentration of salt in a chamber surrounding the reservoir (but isolated from it by an impermeable layer), water enters the pump through its outer surface (a semipermeable layer).

The entry of water increases the volume in the salt chamber, causing compression of the flexible reservoir and delivery of the drug solution into the animal via the exit port.

Loctite 454

Item Number: 0008670
Comes as: 3 gram tube

Loctite 454 is an instant adhesive gel for use with ALZET^® Brain Infusion Kits and other brain infusion cannulae. It offers a convenient alternative to cranioplastic dental cements. A very thin layer on the base of the pedestal adheres the cannula to the skull. Researchers have found it to be ideal for use in mice and other small animals when using short pedestal cannulae.

Product Description & Applications

No mix, instant adhesive gel for use with ALZET ® Brain Infusion Kits and other brain infusion cannulae
One 3 gram tube is enough for 10 brain infusion cannulae implantations
A convenient alternative to cranioplastic / dental cement
A very thin layer on the base of the pedestal adheres the cannula to the dry skull
Ideal for use in mice and other small animals when using short pedestal cannulae

Advantages of Cyanoacrylate Gel Over Dental Cement

Significant time savings for the researcher

Studies indicate a substantial reduction in surgical time compared to the dental cement technique *
Comes ready to use; no need to mix during surgery

Significant animal welfare benefit *

Less stress to the experimental animal
Reduced time under anesthesia
Less adhesive material needed, thereby less overall implant size and weight on the animals
Easier to close the skin over the cannula
Minimal heat generated during curing
Less trauma to animals since fewer (or no) screws required to stabilize the cannula

References

* Criado, A. et al . Use of cyanoacrylate gel as a substitute for dental cement in intracerebroventricular cannulations in rats. Contemporary Topics 2003; 42(3):13-16. (Review of Study)

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	Cyanoacrylate Adhesive (Application Tip) Will you be applying cyanoacrylate adhesive (Loctite 454) to a brain infusion cannula? If so, this technical tip will help you achieve the best results possible. Click here for more information