References on the Administration of Antibodies Using ALZET^® Osmotic Pumps

Q0636 Tsai,S.Y., Papadopoulos,C.M., Schwab,M.E., Kartje,G.L. Delayed Anti-Nogo-A Therapy Improves Function After Chronic Stroke in Adult Rats. Stroke 2011; 42(-1-):186-190. >>> Antibody, anti-Nogo-A; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/ inactive control antibody or no treatment; animal info (adult, male, Long Evans, black-hooded, 300 g); ischemia (stroke).

Q0426 Cho,K.J., Kim,H.J., Park,S.C., Kim,H.W., Kim,G.W. Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death. MOLECULAR AND CELLULAR NEUROSCIENCE 2010; 45(-3-):267-276. >>> Antibody, anti-APE/Ref-1, rabbit; RNA, small interfering; Saline; CSF/CNS (hippocampus); Mice; 1003D; 3 days; Controls received mp w/ vehicle; animal info (3 months old, male, ICR, 35-40 g); siRNA against APE/Ref-1.

P9896 Gillani,R.L., Tsai,S.Y., Wallace,D.G., O'Brien,T.E., Arhebamen,E., Tole,M., Schwab,M.E., Kartje,G.L. Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy. Behavioural Brain Research 2010; 208(-2-):415-424. >>> Antibody, anti-nogo-A; antibody, anti-wheat auxin; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/control antibody; animal info (male, Long Evans, black-headed, 18 mo old, MCAO).

Q0014 Gonzenbach,R.R., Gasser,P., Zoerner,B., Hochreutener,E., Dietz,V., Schwab,M.E. Nogo-A Antibodies and Training Reduce Muscle Spasms in Spinal Cord-Injured Rats. Annals of Neurology 2010; 68(-1-):48-57. >>> Antibody, mouse anti-nogo-A (11C7-10); antibody, mouse anti-nogo-A (7B12-10); immunoglobulin G; PBS; CSF/CNS (intrathecal, injury site); Rat; 2ML2; 2 weeks; Controls received mp w/IgG; animal info (female, Lewis, 180-300 g, SCI); behavioral testing (locomotor assessment).

Q0058 Hughes,E.G., Peng,X.Y., Gleichman,A.J., Lai,M.Z., Zhou,L., Tsou,R., Parsons,T.D., Lynch,D.R., Dalmau,J., Balice-Gordon,R.J. Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis. Journal of Neuroscience 2010; 30(-17-):5866-5875. >>> Antibody, NR1; CSF/CNS (hippocampus); Rat; 2002; 2 weeks; Controls received mp w/ control CSF; ALZET brain infusion kit 3 used; animal info (female, Lewis, 7-8 wks old).

Q0542 Jablonska,B., Aguirre,A., Raymond,M., Szabo,G., Kitabatake,Y., Sailor,K.A., Ming,G.L., Song,H.J., Gallo,V. Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination. Nature Neuroscience 2010; 13(-5-):541-U43. >>> Chordin; antibody, anti-chordin; Saline; CSF/CNS (subventricular zone); Mice; 1007D; 5 days; Controls received mp w/ vehicle; animal info (Dcx-BAC-CreERT2 Tg); ALZET brain infusion kit used; incorrectly stated Model 1007 pumps used; incorrectly listed rate of infusion for Model 1007D pumps as 0.25 ul/hr; chordin is a BMP antagonist.

Q0160 Llorens-Martin,M., Torres-Aleman,I., Trejo,J.L. Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour. MOLECULAR AND CELLULAR NEUROSCIENCE 2010; 44(-2-):109-117. >>> Antibody, anti-IGF1; Saline; SC; Mice; 1004; 2, 3 weeks; Controls received mp w/ saline; animal info (3 months old, male, C57BL/6); behavioral testing (Morris water maze, elevated plus maze, novel onject recognition, treadmill running).

Q0948 Mak,G.K., Weiss,S. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nature Neuroscience 2010; 13(-6-):753-U134. >>> Prolactin, mouse, recomb.; luteinizing hormone, mouse, recomb.; antibody, prolactin neutralizing; Albumin, mouse, serum; PBS;; SC; CSF/CNS; Mice; 1003D; 1007D; 2 days; Controls received mp w/ vehicle or normal goat antibody; animal info (8 wks old, Prlr +/+, Prlr -/-, male).

Q0405 Masuda,Y., Shimizu,A., Kataoka,M., Arai,T., Ishikawa,A., Du,X.Y., Saito,S.K., Aki,K., Nagasaka,S., Mii,A., Fujita,E., Fukuda,Y. Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis. LABORATORY INVESTIGATION 2010; 90(-10-):1468-1481. >>> Antibody, anti-vegf, rabbit, anti-human; Saline; IP; Rat; 2ML1; 1 week; Controls received mp w/rabbit IgG; animal info (male, Wistar, 180 g).

Q0178 Obata,K., Katsura,H., Mizushima,T., Yamanaka,H., Kobayashi,K., Dai,Y., Fukuoka,T., Tokunaga,A., Tominaga,M., Noguchi,K. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury (vol 115, pg 2393, 2005). Journal of Clinical Investigation 2010; 120(-1-):394-394. >>> SB203580; antibody, anti-NGF; oligodeoxynucleotide, antisense; oligodeoxynucleotide, missense; oligodeoxynucleotide, FITC-, antisense; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ missense oligo; animal info (male, Sprague-Dawley, 200-250 g, SNL); antisense (TRPA1); enzyme inhibitor (p38 MAP kinase); 50% DMSO; behavioral testing (basal pain hypersensitivity, paw withdrawal latency, mechanical withdrawal threshold).

Q0027 Paglialunga,S., Fisette,A., Munkonda,M., Gao,Y., Richard,D., Cianflone,K. The effects of acylation stimulating protein supplementation VS antibody neutralization on energy expenditure in wildtype mice. BMC PHYSIOLOGY 2010; 10(-;-):U1-U11. >>> Antibody, anti- acylation stimulating protein; acylation stimulating protein, recomb. human; immunoglobulin G; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/IgG; peptides; animal info (male, C57BL/6, 7-8 weeks old); functionality of mp verified by residual volume.

Q0853 Peeters,K., Loyen,S., Van Kerckhoven,S., Stoffels,K., Hoylaerts,M.F., Van Geet,C., Freson,K. Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis. British Journal of Haematology 2010; 151(-1-):54-61. >>> Antibody, anti CD41/integrin alpha 2b; albumin, human serum; Saline, sterile; SC; Mice; 1007D; 7 days; Controls received control Ab injections; animal info (female, Balb/c); compound also known as MWReg30.

Q0408 Ryu,H.J., Kim,J.E., Kim,M.J., Kwon,H.J., Suh,S.W., Song,H.K., Kang,T.C. THE PROTECTIVE EFFECTS OF INTERLEUKIN-18 AND INTERFERON-gamma ON NEURONAL DAMAGES IN THE RAT HIPPOCAMPUS FOLLOWING STATUS EPILEPTICUS. Neuroscience 2010; 170(-3-):711-721. >>> Antibody, anti IL-18; IL-18, recomb. rat; interferon, gamma, recomb. rat; antibody, anti interferon, gamma; IL-18 receptor antagonist; interferon, gamma, receptor antagonist; Saline; CSF/CNS; Rat; 1007D; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 7 wks old); ALZET brain infusion kit 1 used.

Q0482 Theurl,M., Schgoer,W., Albrecht,K., Jeschke,J., Egger,M., Beer,A.G.E., Vasiljevic,D., Rong,S., Wolf,A.M., Bahlmann,F.H., Patsch,J.R., Wolf,D., Schratzberger,P., Mahata,S.K., Kirchmair,R. The Neuropeptide Catestatin Acts As a Novel Angiogenic Cytokine via a Basic Fibroblast Growth Factor-Dependent Mechanism. Circulation Research 2010; 107(-11-):1326-1U95. >>> Antibody, fibroblast growth factor, b-, mouse; SC; Mice; 3, 4 weeks; Controls received mp w/control antibody; animal info (male, C57BL/6 wild-type, 12-15 mo old).

Q0195 Willi,R., Weinmann,O., Winter,C., Klein,J., Sohr,R., Schnell,L., Yee,B.K., Feldon,J., Schwab,M.E. Constitutive Genetic Deletion of the Growth Regulator Nogo-A Induces Schizophrenia-Related Endophenotypes. Journal of Neuroscience 2010; 30(-2-):556-567. >>> Antibody, monoclonal, anti-nogo-A; antibody, monoclonal IgG; PBS; CSF/CNS (intrathecal); Mice; 1002; 2 weeks; Controls received mp w/ IgG or no mp; brain tissue distribution; animal info (C57BL/6J, 2-4 months old); behavioral testing (elevated plus maze, open field exploration, prepulse inhibition, active avoidance learning, discrimination reversal learning, latent inhibition, social interaction and social novelty, amphetamine-induced locomotor activity); 32 G catheter inserted into the L2 region and advanced to the T10 region.

Q0880 Zhu,X.H., Yan,H.C., Zhang,J., Qu,H.D., Qiu,X.S., Chen,L.A., Li,S.J., Cao,X.O., Bean,J.C., Chen,L.H., Qin,X.H., Liu,J.H., Bai,X.C., Mei,L., Gao,T.M. Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats. Journal of Neuroscience 2010; 30(-38-):12653-12663. >>> K252a; antibody, chicken anti-BDNF; antibody, chicken IgY; CSF, artificial; DMSO; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (3 mo old, Sprague Dawley, 180-220 g, male); 50% DMSO used; depression.

Q0814 Cho,K.J., Lee,B.I., Cheon,S.Y., Kim,H.W., Kim,H.J., Kim,G.W. INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 REDUCES ENDOPLASMIC RETICULUM STRESS AND NUCLEAR HUNTINGTIN FRAGMENTS IN A MOUSE MODEL OF HUNTINGTON DISEASE. Neuroscience 2009; 163(-4-):1128-1134. >>> Antibody, anti-Ask1; CSF/CNs (striatum, intra-); Mice (transgenic); 4 weeks; Controls received mp w/ rabbit IgG or pre-immune Ask1 antibody); animal info (8-12 wks old, R6/2 HD male tg); neurodegenerative (Huntington's disease); behavioral testing (rotarod test); pump infused at a rate of 1 ul/hr.

Q0567 Clausen,F., Haanell,A., Bjoerk,M., Hillered,L., Mir,A.K., Gram,H., Marklund,N. Neutralization of interleukin-1-beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice. European Journal of Neuroscience 2009; 30(-3-):385-396. >>> Antibody, monoclonal IgG2a/k; CSF/CNS; Mice; 2004; 2 weeks; Controls received mp w/ control antibody anti-CsA-IgG); animal info (male C57BL/ 6, 25-27 g); ALZET brain infusion kit 2 used; IgG2a/k is a IL-1b neutralizing antibody.

P9701 Duman,C.H., Schlesinger,L., Terwilliger,R., Russell,D.S., Newton,S.S., Duman,R.S. Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. Behavioural Brain Research 2009; 198(-2-):366-371. >>> Insulin-like growth factor I, recomb. human; antibody, anti-IGF-I, polyclonal; Saline; SC; Mice; 1002; 2004; 14, 28 days; Controls received mp w/vehicle; animal info (male, C57BL/6, 10 wks old); behavioral testing (running wheel test, forced swim test).

P9866 Haylor,J.L., Parker,E., Risbridger,G.P., Beale,D., Brown,B.L., Dobson,P.R.M., Clarke,I.J., Hart,J.E. Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide. REGULATORY PEPTIDES 2009; 152(-1-3-):48-53. >>> EPL001; antibody, EPL001, mouse, monoclonal; Kidney; Rat; 2002; ; Tissue perfusion (renal); replacement therapty (unilateral nephrectomy); peptides; animal info (male, Wistar, 250-300 g.); EPL001 is a novel sheep derived 14 amino acid peptide.

P9416 Isa,K., Garcia-Espinosa,M.A., Arnold,A.C., Pirro,N.T., Tommasi,E.N., Ganten,D., Chappell,M.C., Ferrario,C.M., Diz,D.I. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2) 27 hypertensive rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 297(-1-):R111-R115. >>> Antibody, rabbit anti-rat ANG (1-12); immunoglobulin G, rabbit; CSF, artificial; CSF/CNS; Rat (transgenic); 2ML2; 14 days; Controls received mp w/ IgG; functionality of mp verified by residual volume; no stress (see pg. R111, R112); stability verified by activity of agent in residual volume, 91-98% on day 13; antihypertensive; ALZET brain infusion 2 kit; animal info (male, (mRen2)27 Tg, 22-28 wks old, 550g.); cannula placement confirmed at end of each study.

P9696 Itoh,T., Satou,T., Nishida,S., Tsubaki,M., Hashimoto,S., Ito,H. Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats. MOLECULAR AND CELLULAR BIOCHEMISTRY 2009; 324(-1-2-):191-199. >>> Antibody, anti-amyloid peptide beta; PBS; CSF/CNS (cortex); Rat; 2001; 7 days; Controls received sham operation w/ pump and no cannula; ALZET brain infusion kit 3 used; brain tissue distribution; animal info (male, Wistar, 8-9 wks old, 200-250 g.); traumatic brain injury; Evans blue used to investigate the extent of antibody distribution; behavioral testing (Morris water maze); tissue perfusion (cortex).

Q0150 Kim,G.W., Kim,H.J., Cho,K.J., Kim,H.W., Cho,Y.J., Lee,B.I. The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus. NEUROBIOLOGY OF DISEASE 2009; 36(-1-):169-180. >>> Antibody, anti-beta1-integrin, monoclonal; Saline; CSF/CNS; Mice; 1003D; 3 days; Animal info (adult, male, C57BL/6, 20-25 g).

Q0744 Kohta,M., Kohmura,E., Yamashita,T. Inhibition of TGF-beta 1 promotes functional recovery after spinal cord injury. NEUROSCIENCE RESEARCH 2009; 65(-4-):393-401. >>> Antibody, anti-TGF beta-1; CSF/CNS (intrathecal, spinal cord); Rat; 2002; 2 weeks; Controls received mp w/ control rabbit IgG; animal info (female, Sprague-Dawley, 200-250 g, laminectomy); silastic tubing connected to the pump; spinal cord injury.

Q0577 Kondo,A., Shingo,T., Yasuhara,T., Kuramoto,S., Kameda,M., Kikuchi,Y., Matsui,T., Miyoshi,Y., Agari,T., Borlongan,C.V., Date,I. Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Brain Research 2009; 1296(-;-):127-136. >>> Erythropoietin, human, recomb.; antibody, anti-EPO; Saline; CSF/CNS; Rat; 6 days; 24 hours; Controls received mp w/ rat serum albumin, or control mouse IgG; animal info (male, Fischer 344, 10-12 wks old, 200-250 g, SLC).

P9765 Lu,L., Wang,X., Wu,P., Xu,C.M., Zhao,M., Morales,M., Harvey,B.K., Hoffer,B.J., Shaham,Y. Role of Ventral Tegmental Area Glial Cell Line-Derived Neurotrophic Factor in Incubation of Cocaine Craving. Biological Psychiatry 2009; 66(-2-):137-145. >>> Antibody, anti-GDNF, monoclonal; immunoglobulin, G, mouse; Rat; 2002; 14 days; Controls received mp w/IgG; animal info (male, Long-Evans, male, Sprague Dawley, 325-375 g).

P9706 Maier,I.C., Ichiyama,R.M., Courtine,G., Schnell,L., Lavrov,I., Edgerton,V.R., Schwab,M.E. Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury. Brain 2009; 132(-;-):1426-1440. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/mouse immunoglobulin G; animal info (adult, male, Sprague Dawley, 200-250 g.).

P9352 Major,T.C., Olszewski,B., Rosebury-Smith,W.S. A CCR2/CCR5 Antagonist Attenuates an Increase in Angiotensin II-Induced CD11b+ Monocytes from Atherogenic ApoE-/- Mice. Cardiovascular Drugs and Therapy 2009; 23(-2-):113-120. >>> Angiotensin II; antibody, anti-MCP-1; CCR2, antagonist; SC; Mice; 1002; 7 days; Controls received mp w/ vehicle; animal info (male, C57BL/6, 4-5 old, ApoE -/-).

P9428 Mancinelli,R., Onori,P., Gaudio,E., Demorrow,S., Franchitto,A., Francis,H., Glaser,S., Carpino,G., Venter,J., Alvaro,D., Kopriva,S., White,M., Kossie,A., Savage,J., Alpini,G. Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1. American Journal of Physiology-Gastrointestinal and Liver Physiology 2009; 297(-1-):G11-G26. >>> Follicle-stimulating hormone; antibody, polyclonal anti-FSH; serum, nonimmune; antide; Saline; IP; Rat; 1 week; Controls received mp w/ vehicle; replacement therapy (bile duct ligation); animal info (female, male, Fischer 344, 150-175 g.); antide is a gonadotropin-releasing hormone antagonist.

R0263 Merrill,J.E. In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination. Neuropsychopharmacology 2009; 34(-1-):55-73. >>> Antibody, anti-LINGO-1; Prolactin; CSF/CNS; intrathecal; SC; IP; Mice; rat; 2-3 weeks; Animal info (MOG-induced Experimental Autoimmune Encephalomyelitis).

P9602 Miyashita,T., Koda,M., Kitajo,K., Yamazaki,M., Takahashi,K., Kikuchi,A., Yamashita,T. Wnt-Ryk Signaling Mediates Axon Growth Inhibition and Limits Functional Recovery after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):955-964. >>> Immunoglobulin G, rabbit; antibody, anti Ryk; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp/saline; animal info (Sprague Dawley, 200-250g, female); spinal cord injury; SCI.

P9935 Nesher,M., Dvela,M., Igbokwe,V.U., Rosen,H., Lichtstein,D. Physiological roles of endogenous ouabain in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-6-):H2026-H2034. >>> Antibody, antiouabain; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/rabbit immunoglobulin in circulation; animal info (male wistar, 150-175 g).

P9475 Suga,H., Eto,H., Shigeura,T., Inoue,K., Aoi,N., Kato,H., Nishimura,S., Manabe,I., Gonda,K., Yoshimura,K. IFATS Collection: Fibroblast Growth Factor-2-Induced Hepatocyte Growth Factor Secretion by Adipose-Derived Stromal Cells Inhibits Postinjury Fibrogenesis Through a c-Jun N-Terminal Kinase-Dependent Mechanism. Stem Cells 2009; 27(-1-):238-249. >>> SP 600125; antibody, anti-FGF-L, goat; antibody, anti-mouse HGF, goat; SC; Mice; 1007D; 7 days; Controls received mp w/ PBS; enzyme inhibitor (JNK); animal info (6 wks old, ICR).

Q0626 Wang,X.M., Mao,X.O., Xie,L., Greenberg,D.A., Jin,K.L. Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. Journal of Cerebral Blood Flow and Metabolism 2009; 29(-10-):1644-1654. >>> Antibody, notch1-activating; antibody, Jagged-Fc-anti-Fc; antibody, anti-Fc; DAPT; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 280-310 g); enzyme inhibitor (gamma secretase); middle cerebral artery occlusion (MCAO); DAPT also known as (N-[N-(3,5-difluorophenacetyl)-L-alanyl]S-phenylglycine t-butyl ester).

Q0572 Xu,G., Watanabe,T., Iso,Y., Koba,S., Sakai,T., Nagashima,M., Arita,S., Hongo,S., Ota,H., Kobayashi,Y., Miyazaki,A., Hirano,T. Preventive Effects of Heregulin-21 on Macrophage Foam Cell Formation and Atherosclerosis. Circulation Research 2009; 105(-5-):500-U217. >>> Heregulin, B1; antibody, anti-heregulin-beta 1; Saline; Mice; 4 weeks; Controls received mp w/ vehicle; animal info (13 or 17 wks old, ApoE -/-).

Q0488 Yan,Y.P., Lang,B.T., Vemuganti,R., Dempsey,R.J. Galectin-3 mediates post-ischemic tissue remodeling. Brain Research 2009; 1288(-;-):116-124. >>> Antibody, anti Gal-3, normal, mouse; CSF, artificial; CSF/CNS (ipsilateral striatum); Rat; 1007D; 7 days; Controls received mp w/vehicle and sham surgery; animal info (adult, male, SHR, 270-320 g, MCAO); ischemia (cerebral); artificial CSF recipe, pg 122.

Q0760 Yan,Y.P., Lang,B.T., Vemuganti,R., Dempsey,R.J. Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia. NEUROCHEMISTRY INTERNATIONAL 2009; 55(-8-):826-832. >>> Antibody, anti-OPN, mouse; Antibody, normal, mouse; CSF, artificial; CSF/CNS (striatum); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (adult, male, SHR, focal ischemia, MCAO, 270-320 g); aCSF recipe.

P8776 Baumann,M., Bartholome,R., Peutz-Kootstra,C.J., Smits,J.F.M., Struijker-Boudier,H.A.J. Sustained tubulo-interstitial protection in SHRs by transient losartan treatment: An effect of decelerated aging?. American Journal of Hypertension 2008; 21(-2-):177-182. >>> Losartan; hydralazine; antibody, anti-TGF-B1; antibody, anti-IgG-K1; SC; Rat; 2004; 4 weeks; Controls received mp w/ saline; cardiovascular; antihypertensive; animal info (male, Wistar-Kyoto, SHR, 4 wks old).

P8893 Brenneman,M.M., Wagner,S.J., Cheatwood,J.L., Heldt,S.A., Corwin,J.V., Reep,R.L., Kartje,G.L., Mir,A.K., Schwab,M.E. Nogo-A inhibition induces recovery from neglect in rats. Behavioural Brain Research 2008; 187(-2-):262-272. >>> Antibody, anti-Nogo-A monoclonal 7B12; antibody, anti-Nogo-A monoclonal 11C7; PBS; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ control IgG antibody; no stress (see pg. 264); good methods (pg. 264); post op. care ("clean, warm environment"); pumps removed after 21 days.

P9732 Chen,Z.L., Yu,H.X., Yu,W.M., Pawlak,R., Strickland,S. Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. Journal of Cell Biology 2008; 183(-7-):1299-1313. >>> Laminin-1, mouse purified; Immunoglobulin G, rabbit; Laminin-1, plasmin digested; Antibody, anti-KA1; CSF/CNS (hippocampus); Mice; 1007D; ; Controls received mp w/vehicle, or PBS; peptides; animal info (adult, male, Lam-gamma-1KO); brain tissue distribution.

P8933 Fujii,T., Yonemitsu,Y., Onimaru,M., Inoue,M., Hasegawa,M., Kuwano,H., Sueishi,K. VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis. Atherosclerosis 2008; 200(-1-):51-57. >>> Antibody, anti-VEGF; IP; Mice; 1007D; ; Ischemia (hind limb); animal info (male, C57BL/6, 6-7 wks old).

P9411 Hayashida,K.I., Clayton,B.A., Johnson,J.E., Eisenach,J.C. Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain 2008; 136(-3-):348-355. >>> Antibody, polyclonal sheep anti-BDNF; immunoglobulin G, sheep; Saline; CSF/CNS (intrathecal); Rat; 2002; 11 days; Controls received mp w/ IgG; no stress (see pg. 351); animal info (male, Sprague Dawley, 200-250 g., spinal nerve ligation); behavioral testing (withdrawal threshold); "animals tolerated intrathecal infusion of the antibody to BDNF with no change in spontaneous behavior." (p. 351).

Q0538 Kaneko,M., Hanover,J.L., England,P.M., Stryker,M.P. TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nature Neuroscience 2008; 11(-4-):497-504. >>> 1NM-PP1; antibody, anti-TrkB; K252a; DMSO; Tween 20; saline; PBS; CSF, artificial; SC; CSF/CNS (cortex); Mice; 6 days; Controls received mp w/ vehicle; animal info (TrkBF616A, wt); enzyme inhibitor (TrkB kinase); 4% DMSO used; 2% Tween 20 used.

P9667 Krum,J.M., Mani,N., Rosenstein,J.M. Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Experimental Neurology 2008; 212(-1-):108-117. >>> Antibody, goat, antimouse, flt-1, neutralising; antibody, goat, antimouse, flk-1, neutralizing; immunoglobulin G, goat, normal; CSF, artificial; CSF/CNS (striatum); Rat; 2001; 3, 7 days; Controls received mp w/ goat IgG; animal info (young adult, Wistar); tissue perfusion (striatum).

P9216 Lin,J.S., Chen,Y.S., Chiang,H.S., Ma,M.C. Hypoxic preconditioning protects rat hearts against ischaemia-reperfusion injury: role of erythropoietin on progenitor cell mobilization. JOURNAL OF PHYSIOLOGY-LONDON 2008; 586(-23-):5757-5769. >>> Antibody, polyclonal anti-EPO receptor; immunoglobulin G, rabbit; SC; Rat; 2004; 28 days; Controls received mp w/ rabbit IgG; cardiovascular; ischemia (cardiac MI); animal info (female, Wistar, 200-220 g., hypoxic).

P8752 Marko,S.B., Damon,D.H. VEGF promotes vascular sympathetic innervation. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-6-):H2646-H2652. >>> Antibody, anti-VEGF (164 and 120); immunoglobulin G; PBS; Dye, Evans blue; SC; Rat; 1002; 4, 7, 14, 21 days; Controls received mp w/ control IgG; functionality of mp verified by distribution of dye within surgical area; cardiovascular; animal info (male, Sprague Dawley, denervated femor of artery).

P9377 Miyoshi,K., Obata,K., Kondo,T., Okamura,H., Noguchi,K. Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury. Journal of Neuroscience 2008; 28(-48-):12775-12787. >>> Immunoglobulin G, goat; antibody, anti-interleukin-18; antibody, anti-leukin-18 receptor; interleukin-18 binding protein; RNA, small interfering; PBS; CSF/CNS (intrathecal); Rat; mice; 1003D; 2001; 3, 7 days; Controls received mp w/ vehicle or IgG or negative siRNA; peptides; animal info (male, Sprague Dawley, 200-250 g.; male, C57BL/6 wt, IL-18 -/-, 25-30 g.); siRNA targets TLR4 (toll-like receptor 4) or negative siRNA; behavioral testing (mechanical hypersensitivity, tactile allodynia).

P8820 Muellner,A., Gonzenbach,R.R., Weinmann,O., Schnell,L., Liebscher,T., Schwab,M.E. Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats. European Journal of Neuroscience 2008; 27(-2-):326-333. >>> Antibody, anti-Nogo-A monoclonal 11C7; antibody, anti-Nogo A monoclonal 7B12; Immunoglobulin G, mouse; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/ IgG; post op. care (Baytril); animal info (Lewis, 2 months old, 160-180g. SCI).

P9120 Shen,Q., Wang,Y., Kokovay,E., Lin,G., Chuang,S.M., Goderie,S.K., Roysam,B., Temple,S. Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions. Cell Stem Cell 2008; 3(-3-):289-300. >>> Antibody, GoH3; CSF, artificial; CSF/CNS; Mice (transgenic); 1007D; 6 days; Controls received mp w/ immunoglobulin G, rat; animal info (2-3 months old, Swiss Webster, GFAP-GFP).

P9150 Sugiyama,S., Di Nardo,A.A., Aizawa,S., Matsuo,I., Volovitch,M., Prochiantz,A., Hensch,T.K. Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity. Cell 2008; 134(-3-):508-520. >>> Otx2, protein; antibody, inhibitory otx2; RNA, small interfering, penetratin coupled; CSF/CNS (visual cortex); Mice (transgenic); 1007D; 7 days; Controls received mp w/ vehicle; animal info (Otx2 KO); Otx2 is a homeoprotein.

P9090 Wannier-Morino,P., Schmidlin,E., Freund,P., Belhaj-Saif,A., Bloch,J., Mir,A., Schwab,M.E., Rouiller,E.M., Wannier,T. Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A. Brain Research 2008; 1217(-;-):96-109. >>> Immunoglobulin G, monoclonal, mouse; antibody, anti-Nogo-A monoclonal, human; anitbody, anti-Nogo-A monoclonal, mouse; CSF/CNS (intrathecal); Monkey; 2ML2; ; Control animals received mp w/ control antibodies; animal info (macaque, 3-8 years old); pumps replaced every 2 weeks; polyethylene tubing used; spinal cord injury.

P8364 Deng,R., Balthasar,J.P. Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia. Blood 2007; 109(-6-):2470-2476. >>> Antibody, MWReg30 antiplatelet; Saline, sterile; BSA; IP; Mice; 1007D; 7 days; Cardiovascular; animal info (female, Balb/C, 20g.); MWReg30-induced thrombocytopenia; "The continuous infusion of antiplatelet antibody may more closely resemble sustained production of antiplatelet antibodies in chronic cases of human ITP, and this may allow a more meaningful evaluation of experimental therapies." (pg. 2475).

P8515 Ishii,T., Muranaka,R., Tashiro,O., Nishimura,M. Chronic intracerebroventricular administration of anti-neuropeptide Y antibody stimulates starvation-induced feeding via compensatory responses in the hypothalamus. Brain Research 2007; 1144(--):91-100. >>> Antibody, rabbit, anti-neuropeptide Y; Saline; CSF/CNS; Mice; 2002; 13 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; ALZET brain infusion kit 3 used; animal info (male, ddy, 7 weeks old, 35-40 g).

P8826 Kyoto,A., Hata,K., Yamashita,T. Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Research 2007; 1186(-;-):74-86. >>> Antibody, anti-RgMa; Immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ control rabbit IgG; animal info (female, Wistar, 200-250g., SCI); repulsive guidance molecule (RGMa) is a myelin-derived neurite outgrowth inhibitor.

P9424 Lefebvre-Roque,M., Kremmer,E., Gilch,S., Zou,W.Q., Feraudet,C., Gilles,C.M., Sales,N., Grassi,J., Gambetti,P., Baron,T., Schaetzl,H., Lasmezas,C.I. Toxic Effects of Intracerebral PrP Antibody Administration During the Course of BSE Infection in Mice. Prion 2007; 1(-3-):198-206. >>> Antibody, anti-PrP-4H11; immunoglobulin, IgG2a; antibody, Fab fragments; CSF, artificial; CSF/CNS; Mice (transgenic); 1002; 15 days; Controls received mp w/ IgG; ALZET brain infusion kit 1 used; brain tissue distribution; animal info (Tg20, 8 wks old, BSE-infected); prion disease; "The antibodies diffused in the brain to an extent which was beyond our expectation." (p. 204).

P8746 Ma,Q.L., Harris-White,M.E., Ubeda,O.J., Simmons,M., Beech,W., Lim,G.P., Teter,B., Frautschy,S.A., Cole,G.M. Evidence of A beta and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. Journal of Neurochemistry 2007; 103(-4-):1594-1607. >>> Antibody, monoclonal anti-amyloid peptide B (1-15); immunoglobulin IgG2b; PBS; CSF/CNS; Mice (transgenic); 1002; 14 days; Controls received mp w/ non-specific mouse IgG2b; animal info (Tg2576, Tg-; 12, 22 months old); neurodegenerative (Alzheimer's disease); "AB vaccine or anti-AB antibodies are still among the most promising treatments for AD." (p. 1605).

P8638 Mi,S., Hu,B., Hahm,K.M., Luo,Y., Hui,E.S.K., Yuan,Q.J., Wong,W.M., Wang,L., Su,H.X., Chu,T.H., Guo,J.S., Zhang,W.M., So,K.F., Pepinsky,B., Shao,Z.H., Graff,C., Garber,E., Jung,V., Wu,E.X., Wu,W. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Medicine 2007; 13(-10-):1228-1233. >>> Antibody, anti, LINGO-1; CSF/CNS (intrathecal); Rat; 36 days; Controls received mp w/ isotype control antibody; pumps replaced every 2-weeks, anti-LINGO-1 is an IgG1-isotype antibody.

P8533 Morrey,J.D., Siddharthan,V., Olsen,A.L., Wang,H., Julander,J.G., Hall,J.O., Li,H., Nordstrom,J.L., Koenig,S., Johnson,S., Diamond,M.S. Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model. Antimicrob.Agents Chemother. 2007/7; 51(-7-):2396-2402. >>> Antibody, monoclonal, hE16; CSF/CNS (pons); Hamster; 2001D; 24 hours; Controls received aCSF; functionality of mp verified by previous study with dye; comparison of IP injections vs. mp; post op. care (buprenorphine); animal info (female, Syrian golden, >7 weeks old); cannula placement confirmed with dye; E16 is anti-domain III of the West Nile Virus envelope protein.

P8409 Prada,C.M., Garcia-Alloza,M., Betensky,R.A., Zhang-Nunes,S.X., Greenberg,S.M., Bacskai,B.J., Frosch,M.P. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. Journal of Neuroscience 2007; 27(-8-):1973-1980. >>> Antibody, anti-amyloid protein beta (10D5); antibody, anti-human tau (16B5); Dye, indocyanine green; CSF/CNS; Mice (transgenic); 2002; 14 days; Controls received mp w/ anti-Tau AB; comparison of single CNS injection vs. mp; animal info (Tg2576, 10-13 months old); neurodegenerative (Alzheimer's disease, CAA); permanent cranial window for serial imaging with multiphoton laser-scanning microscopy; "with continuous infusion of anti-AB antibody, the clearance of CAA was more robust and continued throughout the duration of the treatment." (pg. 1978).

P8525 Saito,H., Kojima,T., Takahashi,M., Horne,W.C., Baron,R., Amagasa,T., Ohya,K., Aoki,K. A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis. Arthritis and Rheumatism 2007; 56(-4-):1164-1174. >>> Peptide, WP9QY; antibody, monoclonal, anti-TNF alpha; PBS; DMSO; SC; Mice; 2001; 19 days; Controls received mp w/ vehicle; dose-response (fig. 1); pumps replaced every 7 days; half-life (p. 1182) "short;" peptides; animal info (male, DBA/1J, 6 weeks old, collagen induced arthritis); 10% DMSO.

P8447 Sheehan,J.J., Zhou,C., Gravanis,I., Rogove,A.D., Wu,Y.P., Bogenhagen,D.F., Tsirka,S.E. Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. Journal of Neuroscience 2007; 27(-7-):1738-1745. >>> Antibody, anti-MCP-1; serum, goat; immunoglobulin G1, mouse; monocyte chemoattractant protein-1 recomb.; antiplasmin, alpha2-; PBS; CSF/CNS (hippocampus); Mice; 1007D; 7 days; Peptides; animal info (C57BL/6, wt, MCP-1 -/-, tPA -/-, plg -/-, 20-25g); neurodegenerative.

P8609 Tsai,S.Y., Markus,T.M., Andrews,E.M., Cheatwood,J.L., Emerick,A.J., Mir,A.K., Schwab,M.E., Kartje,G.L. Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke. Experimental Brain Research 2007; 182(-2-):261-266. >>> Antibody, anti-Nogo-A monoclonal; antibody, immunoglobulin G 1, anti-wheat auxin; CSF/CNS (intrathecal, lumbar); Rat; 2ML2; 2 weeks; Controls received mp w/ IgG1 or no treatment; brain tissue distribution; animal info (male, Long-Evans, 300 grams, MCAO); ischemia (cerebral); "anti-Nogo-A immunotherapy delivered through the more accessible intrathecal route is an effective way to restore neurological function following stroke." (p. 265).

P8266 Urushitani,M., bou Ezzi,S., Julien,J.P. Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-7-):2495-2500. >>> Antibody, mouse anti hSOD1; antibody, rabbit polyclonal anit-hSOD1-FITC; Saline; CSF/CNS; Mice; 2004; 16, 28 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; stability verified by Western Blot w/ residual volume AB after 18 days infusion; brain tissue distribution; animal info (G93A SOD1, 85 days old); neurodegenerative (ALS).

P7977 Yamanaka,H., Obata,K., Kobayashi,K., Dai,Y., Fukuoka,T., Noguchi,K. Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain. European Journal of Neuroscience 2007; 25(-4-):1097-1111. >>> Immunoglobulin G, non-immune mouse; antibody, anti-L1-CAM; SB203580; Saline; CSF/CNS (intrathecal); Rat; 2001; 2002; ; Animal info (Male, Sprague-Dawley, 200-250 grams); Silascon tubing, 0.64 mm O.D filled with 5.0 ul's of saline; inserted ~ 0.5 cm's into the intrathecal space; enzyme inhibitor (p38 MAP kinase).

P8029 Dijkstra,S., Duis,S., Pans,I.M., Lankhorst,A.J., Hamers,F.P.T., Veldman,H., Baer,P.R., Gispen,W.H., Joosten,E.A.J., Geisert,EE Jr  Experimental Neurology 2006; 202(-1-):57-66. >>> Antibody, anti-CD81; immunoglobulin, G; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Post op. care (fluid therapy, 3.0 ml saline); animal info (adult, female, Wistar, 11 weeks old, 200-240 grams); spinal cord cannulation technique outlined (p. 58); PE tubing used; pump functionality measured incorrectly; x-ray image of pump/cannulation (p. 59); behavioral study.

P8121 Fujii,T., Yonemitsu,Y., Onimaru,M., Tanii,M., Nakano,T., Egashira,K., Takehara,T., Inoue,M., Hasegawa,M., Kuwano,H., Sueishi,K. Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2- mediated therapeutic neovascularization - Critical role of the inflammatory/arteriogenic pathway. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2006; 26(-11-):2483-2489. >>> Antibody, anti-VEGF; IP; Mice (nude); 1007D; ; Controls received mp w/ IgG; cardiovascular; ischemia (hind limb); animal info (male, C57BL/6, 6-7 wk. old; Balb/c nu/nu, 5 wk. old; C57BL/6, CCR2-/-).

P7814 Hata,K., Fujitani,M., Yasuda,Y., Doya,H., Saito,T., Yamagishi,S., Mueller,B.K., Yamashita,T. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Journal of Cell Biology 2006; 173(-1-):47-58. >>> Antibody, anti-rat RGMA; immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ rabbit IgG; animal info (female, Wistar, 200-250g., spinal cord hemisection); repulsive guidance molecule (RGM).

P8129 Heinrich,C., Nitta,N., Flubacher,A., Muller,M., Fahrner,A., Kirsch,M., Freiman,T., Suzuki,F., Depaulis,A., Frotscher,M., Haas,C.A. Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. Journal of Neuroscience 2006; 26(-17-):4701-4713. >>> Antibody, monoclonal, CR-50; immunoglobulin G, mouse; DMEM; CSF/CNS (hippocampus); Mice; 1007D; 7 days; Controls received mp w/ mouse IgG; ALZET brain infusion kit use; brain tissue distribution; animal info (male, C57BL/6, 8-10 wks old); Reelin-neutralizing antibody; DMEM is Dulbecco's modified eagle medium; tissue perfusion (hippocampus).

P8136 Ishii,K., Nakamura,M., Dai,H.N., Finn,T.P., Okano,H., Toyama,Y., Bregman,B.S. Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury. Journal of Neuroscience Research 2006; 84(-8-):1669-1681. >>> Antibody, polyclonal goat anti-CNTF; immunoglobulin-G, goat; CSF/CNS (Intrathecal, subarachnoid space); Rat; 2002; 14 days; Controls received mp w/ IgG; brain tissue distribution; animal info (female, Sprague-Dawley, 250-300g. spinal cord lesioning, NSC transplant).

P8225 Kondo,N., Sekijima,T., Kondo,J., Takamatsu,N., Tohya,K., Ohtsu,T. Circannual control of hibernation by HP complex in the brain. Cell 2006; 125(-1-):161-172. >>> Antibody, polyclonal, anti-HP20c; immunoglobulin G, rabbit; PBS; CSF/CNS; Chipmunk; 2002; 2 weeks; Controls received mp w/ IgG; dose-response (fig. 6); animal info (male, tamias sibiricus, hibernating).

P7812 Ma,Q.L., Lim,G.P., Harris-White,M.E., Yang,F.S., Ambegaokar,S.S., Glabe,C.G., Teter,B., Frautschy,S.A., Cole,G.M. Antibodies against beta-amyloid reduce A beta oligomers, glycogen synthase kinase-3 beta activation and tau phosphorylation in vivo and in vitro. Journal of Neuroscience Research 2006; 83(-3-):374-384. >>> Antibody, monoclonal, anti-amyloid protein, beta (1-15); immunoglobulin, IgG2b, mouse; PBS; CSF/CNS; Mice (transgenic); 1002; 14 days; Controls received mp w/ mouse IgG2b; post op. care (marcaine); neurodegenerative (Alzheimer's disease); animal info (male, female, 11-12 month old).

P8208 Martens,T., Schmidt,N.O., Eckerich,C., Fillbrandt,R., Merchant,M., Schwall,R., Westphal,M., Lamszus,K. A novel one-armed anti-c-met antibody inhibits glioblastoma growth in vivo. Clinical Cancer Research 2006; 12(-20-):6144-6152. >>> Antibody, anti-c-Met, OA5D5; Histidine; CSF/CNS (intratumoral); Mice (nude); 2004; 12, 21, 28 days; Controls received mp w/ vehicle; cancer (glioblastoma); ALZET brain infusion kit 2 used; animal info (male, NMRI-nu/nu, 6-8 wks old); "Because the OA-5D5 antibody is a relatively large but stable molecule, convection-enhanced drug delivery (by mp) was ideally suited to deliver it in our orthotopic model." (p.6151); tissue perfusion (tumor).

P8071 Morrey,J.D., Siddharthan,V., Olsen,A.L., Roper,G.Y., Wang,H., Baldwin,T.J., Koenig,S., Johnson,S., Nordstrom,J.L., Diamond,M.S. Humanized monoclonal antibody against West Nile virus envelope protein administered after neuronal infection protects against lethal encephalitis in hamsters. Journal of Infectious Diseases 2006; 194(-9-):1300-1308. >>> Antibody, monoclonal, hE16; CSF, artificial; CSF/CNS (parenchyma); Hamster; 2001D; 24 hours; Controls received mp w/ vehicle, or saline; comparison of ip injections vs. mp; brain tissue distribution; animal info (female, Syrian golden, 7 wks. old, 116g., infected w/ West Nile Virus); hE16 is specific for WNV envelope protein domain III "this delivery system facilitated broad delivery of Ab into the brain, with highest levels near the site of cannulation." (p.1305); tissue perfusion (parenchyma).

P7870 Nakai,S., Matsunaga,W., Ishida,Y., Isobe,K., Shirokawa,T. Effects of BDNF infusion on the axon terminals of locus coeruleus neurons of aging rats. NEUROSCIENCE RESEARCH 2006; 54(-3-):213-219. >>> Brain-derived neurotrophic factor; antibody, anti-BDNF; brain-derived neurotrophic factor, biotin-labeled; immunoglobulin G; PBS; BSA; CSF/CNS (frontal cortex); Rat; 2002; 14 days; Controls received mp w/ vehicle, or IgG; dose-response (fig. 3); ALZET brain infusion kit used; brain tissue distribution; peptides; post op. care (enrofloxacin); animal info (male, F344/N, 13 month old, 19 month old); mp primed 3-6 hours in 37 celsius saline.

P8028 Obata,K., Katsura,H., Sakurai,J., Kobayashi,K., Yamanaka,H., Dai,Y., Fukuoka,T., Noguchi,K. Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury. Journal of Neuroscience 2006; 26(-46-):11974-11986. >>> Antibody, anti-NGF; antibody, anti-P75NTR; K252a; DMSO; saline; CSF/CNS (intrathecal, lumbar); Rat; 2001; ; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 200-250 grams); nerve injury; silastic tubing used; K252a in 50% DMSO; behavioral testing.

P8414 Ohab,J.J., Fleming,S., Blesch,A., Carmichael,S.T. A neurovascular niche for neurogenesis after stroke. Journal of Neuroscience 2006; 26(-50-):13007-13016. >>> Antibody, anti-mouse Tie2, biotin conjugated; antibody, anti-mouse Tie2 antiopoietin 1, biotin conjugated; angiopoietin 1; AMD 3100; stromal-derived factor 1B, biotin conjugated; stromal cell-derived factor 1b, recomb.; PBS; Mice (transgenic); 1007D; 3,5,7 days; Controls received mp w/ vehicle; dose-response (fig. 7); cardiovascular; peptides; animal info (C57BL/6, 2 months old); Middle cerebral artery occlusion; transient bilateral common carotid occlusion.

P8322 Sakaguchi,M., Shingo,T., Shimazaki,T., Okano,H.J., Shiwa,M., Ishibashi,S., Oguro,H., Ninomiya,M., Kadoya,T., Horie,H., Shibuya,A., Mizusawa,H., Poirier,F., Nakauchi,H., Sawamoto,K., Okano,H. A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-18-):7112-7117. >>> Antibody, anti-galectin-1; immunoglobulin G, rabbit; Saline; albumin, mouse serum; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle or rabbit IgG; peptides; animal info (male, 1295J wt or galectin-1 -/-, 8 weeks old).

P8277 Shi,X., Semkova,I., Muether,P.S., Dell,S., Kociok,N., Joussen,A.M. Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization. Experimental Eye Research 2006; 83(-6-):1325-1334. >>> Etanercept; infliximab; antibody, monoclonal rat anti-mouse/rat TNF-alpha; Water, sterile; PBS; IP; Mice; 2001; 7 days; Controls received mp w/ vehicle; animal info (female, C57BL/6J, 4-6 wks old, laser eye injury); fluorescein angiography; "we administered etanercept systemically via osmotic pumps to achieve a permanent therapeutic concentration of the drug for 7 days." (p. 1331).

P8045 Thompson,H.J., Marklund,N., LeBold,D.G., Morales,D.M., Keck,C.A., Vinson,M., Royo,N.C., Grundy,R., McIntosh,T.K. Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody. European Journal of Neuroscience 2006; 24(-11-):3063-3072. >>> Antibody, anti-MAG mAb; CSF/CNS; 1003D; 3 days; ALZET brain infusion kit 1 used; brain tissue distribution; animal info (male, Sprague-Dawley, 350-400 grams); cannula secured via tissue adhesive; 35 mm long PE tubing used.

P6908 Alonso,G., Galibert,E., Duvoid-Guillou,A., Vincent,A. Hyperosmotic stimulus induces reversible angiogenesis within the hypothalamic magnocellular nuclei of the adult rat: a potential role for neuronal vascular endothelial growth factor. BMC NEUROSCIENCE 2005; 6(--):U1-U19. >>> Antibody, anti-vascular endothelial growth factor; PBS; CSF/CNS (supraoptic nucleus); Rat; 1007D; 6 days; Schematic fig 9; 10 mm, 26 gauge cannula used.

P6902 Fouad,K., Schnell,L., Bunge,M.B., Schwab,M.E., Liebscher,T., Pearse,D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. Journal of Neuroscience 2005; 25(-5-):1169-1178. >>> Chondroitinase ABC; antibody, immunoglobulin G, recomb. mouse; galactosidase; Saline; PBS; CSF/CNS (intrathecal, lumbar); Rat; 2002; 4 weeks; Comparison of IT injections vs. mp; pumps replaced at two weeks; post op. care (antibiotic); spinal cord injury; Recathco catheter used; behavioral study.

P7332 Gu,Z.Z., Cui,J., Brown,S., Fridman,R., Mobashery,S., Strongin,A.Y., Lipton,S.A. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. Journal of Neuroscience 2005; 25(-27-):6401-6408. >>> Antibody, rabbit anti-pan laminin; serum, rabbit; PBS; BSA; CSF/CNS (cortex); Mice; 1007D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral); MCA occlusion.

P7367 Lenzlinger,P.M., Shimizu,S., Marklund,N., Thompson,H.J., Schwab,M.E., Saatman,K.E., Hoover,R.C., Bareyre,F.M., Motta,M., Luginbuhl,A., Pape,R., Clouse,A.K., Morganti-Kossmann,C., McIntosh,T.K. Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats. Neuroscience 2005; 134(-3-):1047-1056. >>> Antibody, anti Nogo-A monoclonal 11C7; PBS; CSF/CNS; Rat; 2ML2; 14 days; Controls received mp w/ IgGAb; ALZET brain infusion kit 2 used; behavioral study; traumatic brain injury.

P7449 Li,S.L., Saragovi,H.U., Nedev,H., Zhao,C.N., Racine,R.J., Fahnestock,M. Differential actions of nerve growth factor receptors TrkA and p75(NTR) in a rat model of epileptogenesis. MOLECULAR AND CELLULAR NEUROSCIENCE 2005; 29(-2-):162-172. >>> Peptides, NGF mimics; antibody, anti-NGF monoclonal, NGF30; immunoglobulin G; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or control peptide or IgG; peptides; post op. care (penicillin, apo-sulfatrim); animal info (male Long-Evans, hooded); cannula placement verified with cresyl violet staining; peptides: c25-35, c30-35, c92-92, ss51 (control).

P7556 Liebscher,T., Schnell,L., Schnell,D., Scholl,J., Schneider,R., Gullo,M., Fouad,K., Mir,A., Rausch,M., Kindler,D., Hamers,F.P.T., Schwab,M.E. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Annals of Neurology 2005; 58(-5-):706-719. >>> Antibody, monoclonal mouse; anti-rat Nogo-A (623-640); antibody, monoclonal mouse; anti-Nogo-A (1-979); antibody, monoclonal mouse; anti- wheat auxin; PBS; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/ monoclonal anti-wheat auxin Ab; functionality verified by Ab concentrations in CSF; post op. care (baytril, analgesic); animal info (female, Lewis, spinal cord lesion).

P7553 Markus,T.M., Tsai,S.Y., Bollnow,M.R., Farrer,R.G., O'Brien,T.E., Kindler-Baumann,D.R., Rausch,M., Rudin,M., Wiessner,C., Mir,A.K., Schwab,M.E., Kartje,G.L. Recovery and brain reorganization after stroke in adult and aged rats. Annals of Neurology 2005; 58(-6-):950-953. >>> Antibody, anti-Nogo-A monoclonal 7B12; antibody, immunoglobulin G, mouse; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/ mouse IgG or no treatment; ischemia (cerebral); animal info (3-4 months old, 25 months old).

P7244 Obata,K., Katsura,H., Mizushima,T., Yamanaka,H., Kobayashi,K., Dai,Y., Fukuoka,T., Tokunaga,A., Tominaga,M., Noguchi,K. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. Journal of Clinical Investigation 2005; 115(-9-):2393-2401. >>> SB203580; antibody, anti-nerve growth factor; oligodeoxynucleotide, antisense; oligodeoxynucleotide, FITC antisense; oligodeoxynucleotide, missense; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle, or sham surgery or mismatch ODN or contralateral no treatment; antisense (TRPA1); brain tissue distribution; 50% DMSO.

P7201 Perrin,F.E., Lacroix,S., viles-Trigueros,M., David,S. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain 2005; 128(--):854-866. >>> Antibody, anti-MCP-1/MIA-1a; antibody, anti-IL-1B; immunoglobulin G; CSF/CNS (sciatic nerve); Mice; 1007D; 7 days; Controls received mp w/ IgG; animal info (adult female, BALB/c); tissue perfusion (sciatic nerve).

P7776 Stoyanovitch,A.G., Johnson,M.A., Clifton,D.K., Steiner,R.A., Fraley,G.S. Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes 2005; 54(-8-):2471-2476. >>> Galanin-like peptide; antibody, anti-GALP; immunoglobulin G, goat; CSF, artificaial; CSF/CNS; Rat; 2002; 11 days; Controls received mp w/ vehicle, or IgG; functionality of mp verified; AlZET brain infusion kit 2 used; peptides; animal info (adult, male, Sprague-Dawley, 280-320g.); catheter filled with vehicle to allow 6.5 days delay treatment before agent; cannula placement confirmed.

P7574 Yamashita,N., Tashimo,H., Ishida,H., Matsuo,Y., Arai,H., Nagase,H., Adachi,T., Ohta,K. Role of insulin-like growth factor-I in allergen-induced airway inflammation and remodeling. Cellular Immunology 2005; 235(-2-):85-91. >>> Antibody, anti-IGF-I, murine; immunoglobulin G, goat; Saline, physiological; SC; Mice; 2 weeks; Controls received mp w/ goat IgG; dose-response (fig 2); immunology; animal info (male, 10-12 wk old).

P6913 Apte,R.S., Barreiro,R.A., Duh,E., Volpert,O., Ferguson,T.A. Stimulation of neovascularization by the anti-angiogenic factor PEDF. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2004; 45(-12-):4491-4497. >>> Pigment epithelium-derived growth factor; antibody, anti-PEDF; SC; Mice; 2001; 7 days; Dose-response (4492, 4495); peptides; PEDF; "...we decided to use a subcutaneously implanted pump to deliver PEDF to circumvent any effects on angiogenesis as a result of iatrogenic trauma." (p. 4492); antiangiogenesis.

P6798 Brussee,V., Cunningham,F.A., Zochodne,D.W. Direct insulin signaling of neurons reverses diabetic neuropathy. Diabetes 2004; 53(-7-):1824-1830. >>> Insulin, human; FITC-Insulin; Insulin-like growth factor I; antibody, polyclonal anti-rat insulin; dye, india ink; antibody, polyclonal anti-albumin; Saline; SC; CSF/CNS (intrathecal); Rat; 2, 4 weeks; Controls received mp w/ vehicle or anti-albumin Ab; functionality of mp verified by dye; replacement therapy (streptozotocin induced diabetes); india ink used to confirm catheter placement and intrathecal delivery.

P6775 Gawlick,U., Kranz,D.M., Schepkin,V.D., Roy,E.J. A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors. Bioconjugate Chemistry 2004; 15(-5-):1137-1145. >>> Antibody, anti-CD28 Fab/Folate; gadolinium; PBS; CSF/CNS (intratumoral); Mice (transgenic); 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by MRI w/ gadolinium infusion; comparison of IV, SC, ICV injections vs. mp; cancer (brain, choroid plexus); brain tissue distribution; MRI; cyanoacrylate adhesive; "The strongest effect on tumor growth assessed of anti-CD28 fab/Folate." (p. 1143). Plastics One cannula used.

P6354 Harrington,A.W., Leiner,B., Blechschmitt,C., Arevalo,J.C., Lee,R., Moerl,L., Meyer,M., Hempstead,B.L., Yoon,S.O., Giehl,K.M. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-16-):6226-6230. >>> Antibody, anti-nerve growth factor, neutralizing mouse; serum; immunoglobulin-G; penicillin; streptomycin; PBS; CSF/CNS (cortex); Rat; 2001; 1 week; Controls received mp w/ vehicle.

P6834 Hashiya,N., Jo,N., Aoki,M., Matsumoto,K., Nakamura,T., Sato,Y., Ogata,N., Ogihara,T., Kaneda,Y., Morishita,R. In vivo evidence of angiogenesis induced by transcription factor ets-1 - Ets-1 is located upstream of angiogenesis cascade. Circulation 2004; 109(-24-):3035-3041. >>> Antibody, anti-vascular endothelical growth factor; antibody, immunoglobulin G, rabbit; IP; Mice; ; Cardiovascular; ischemia.

P6554 Hjortland,G.O., Garman-Vik,S.S., Juell,S., Olsen,O.E., Hirschberg,H., Fodstad,O., Engebraaten,O. Immunotoxin treatment targeted to the high-molecular-weight melanoma-associated antigen prolonging the survival of immunodeficient rats with invasive intracranial human glioblastoma multiforme. Journal of Neurosurgery 2004; 100(-2-):320-327. >>> Antibody, monoclonal 9.2.27 - pseudomonas exotoxin A; dye, evans blue; PBS; CSF/CNS (intratumoral); Rat (nude); 2001D; 24 hours; Controls received mp w/ PBS; cancer (glioma biopsy tumors); ALZET brain infusion kit used; brain tissue distribution; mp primed in sterile saline at 37 degrees Celsius for 4 hours; mp removed after 3 days.

P7032 Huang,B.S., Van Vliet,B.N., Leenen,F.H.H. Increases in CSF [Na+] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet. American Journal of Physiology-Heart and Circulatory Physiology 2004; 287(-3-):H1160-H1166. >>> Ouabain; antibody, fab fragment; gamma globulin; CSF, artificial; CSF/CNS; Rat; 2002; 7-8,14 days; Controls received mp w/ vehicle, or gammaglobulins; cardiovascular; fab fragments binding ouabain-like compounds (OLC) with high affinity.

P6630 King,V.R., Phillips,J.B., Brown,R.A., Priestley,J.V. The effects of treatment with antibodies to transforming growth factor beta 1 and beta 2 following spinal cord damage in the adult rat. Neuroscience 2004; 126(-1-):173-183. >>> Antibody, anti-TGF-beta 1; antibody, anti-TGF-beta 2; Saline; CSF/CNS (intrathecal); Rat; 1007D; 1 week; Controls received mp w/ vehicle; comparison of fibronectin mats vs. mp; brain tissue distribution; TGF is transforming growth factor; FN mats and mp "showed a similar pattern of results." (p. 175).

P6614 Kodama,I., Niida,S., Sanada,M., Yoshiko,Y., Tsuda,M., Maeda,N., Ohama,K. Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. Journal of Bone and Mineral Research 2004; 19(-2-):200-206. >>> Antibody, anti-vascular endothelial growth factor; vascular endothelial growth factor; Flt-1/Fe chimera; SC; Mice; 1002; 2 weeks; Plasma levels taken.

P6822 Lee,J.K., Kim,J.E., Sivula,M., Strittmatter,S.M. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. Journal of Neuroscience 2004; 24(-27-):6209-6217. >>> Antibody, NgR (310) Ecto-Fc; Immunoglobulin G, rat; PBS; CSF/CNS; Rat; 2ML4; 9 weeks; Controls received mp w/ rat IgG; long-term study; pumps replaced after 28 days; good methods (p. 6210); ALZET brain infusion kit 2 used; peptides; cyanoacrylate adhesive; ischemia (cerebral); Nogo-Nogo receptor (NgR); NgR (310) Ecto-Fc is an IgG fusion protein with a soluble ectodomain fragment of NgG; behavioral study.

P6858 Lopez-Lopez,C., LeRoith,D., Torres-Aleman,I. Insulin-like growth factor I is required for vessel remodeling in the adult brain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-26-):9833-9838. >>> Insulin-like growth factor I; antibody, anti-IGF I; serum, rabbit; SC; Mice; 2001; 2 weeks; 28 days; Controls received mp w/ saline or serum; comparison of microsphere injections vs. mp.

P6440 Matsunaga,W., Shirokawa,T., Isobe,K. BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain. NEUROBIOLOGY OF AGING 2004; 25(-3-):341-348. >>> Brain-derived neurotrophic factor; BDNF antibody-; immunoglobulin G; PBS; CSF/CNS (frontal cortex); Rat; 2002; 13-15 days; Controls received mp w/ vehicle; post op. care (antibiotic for 5 days after operation); cannula secured by dental cementl; BDNF dissolved in PBS (pH 7.4); brain tissue distribution was measured by biotin-labeled BDNF.

P7023 Obata,K., Yamanaka,H., Kobayashi,K., Dai,Y., Mizushima,T., Katsura,H., Fukuoka,T., Tokunaga,A., Noguchi,K. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. Journal of Neuroscience 2004; 24(-45-):10211-10222. >>> U0126; SB203580; FR167653; SP 600125; antibody, anti-NGF, sheep; DMSO, saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; enzyme inhibitors (MAPK kinase, p38, JNK); 50% DMSO used.

P6384 Poulaki,V., Mitsiades,N., Kruse,F.E., Radetzky,S., Iliaki,E., Kirchhof,B., Joussen,A.M. Activin A in the regulation of corneal neovascularization and vascular endothelial growth factor expression. American Journal of Pathology 2004; 164(-4-):1293-1302. >>> Antibody, anti-activin A; activin A; PBS; IP; Mice; 1007D; 8 days; Controls received mp w/ vehicle or control antibody.

P6915 Poulaki,V., Joussen,A.M., Mitsiades,N., Mitsiades,C.S., Iliaki,E.F., Adamis,A.P. Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy. American Journal of Pathology 2004; 165(-2-):457-469. >>> Wortmannin; ly294002; antibody, monoclonal aLR-3; SP600125; SN50; geldanamycin; IP; Rat; 2002; 7 days; Enzyme inhibitor (P1-3K, JNK); diabetes.

P6776 Reynolds,J.L., Ignatowski,T.A., Sud,R., Spengler,R.N. Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant. Journal of Pharmacology and Experimental Therapeutics 2004; 310(-3-):1216-1225. >>> Tumor necrosis factor, recomb. rat; tumor necrosis factor, recomb. rat inactivated; serum, rabbit; antibody, polyclonal rabbit anti-mouse TNF; CSF, artificial; albumin, rat; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or heat-inactivated rr TNF; no stress (see pg. 1217-18); ALZET Brain Infusion Kit used.

P6451 Seki,S., Sasaki,K., Igawa,Y., Nishizawa,O., Chancellor,M.B., De Groat,W.C., Yoshimura,N. Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. Journal of Urology 2004; 171(-1-):478-482. >>> Antibody, anti-nerve growth factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; spinal cord injury; PE-10 used for catheterization.

P6786 Stein,T.D., Anders,N.J., DeCarli,C., Chan,S.L., Mattson,M.P., Johnson,J.A. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis. Journal of Neuroscience 2004; 24(-35-):7707-7717. >>> Antibody, anti-transthyretin; immunoglobulin G, goat; CSF, artificial; CSF/CNS (hippocampus); Mice (transgenic); mice; 2002; ; Controls received mp w/ goat IgG; ALZET Brain Infusion Kit used; brain tissue distribution; cyanoacrylate adhesive; neurodegenerative disease (Alzheimer's).

P6527 Tan,J.H., Wang,H., Leenen,F.H.H. Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats. American Journal of Physiology-Heart and Circulatory Physiology 2004; 286(-5-):H1665-H1671. >>> Antibody, fab fragments; gamma globulin; CSF/CNS; Rat; 2002; 4 weeks; Pumps replaced every two weeks; 23 gauge cannula used.

P6633 Tsutsumi,N., Yonemitsu,Y., Shikada,Y., Onimaru,M., Tanii,M., Okano,S., Kaneko,K., Hasegawa,M., Hashizume,M., Maehara,Y., Sueishi,K. Essential role of PDGFR alpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo - Role of PDGFR alpha during angiogenesis. Circulation Research 2004; 94(-9-):1186-1194. >>> Antibody, polyclonal anti-PDGF-AA; IP; Mice; 1007D; 2001; 7 days; Cancer; cardiovascular.