References on the Administration of Antibodies Using ALZET® Osmotic Pumps

16257 Ahl, M., Avdic, U., Skoug, C., Ali, I., Chugh, D., Johansson, U. E., Ekdahl, C. T. Immune response in the eye following epileptic seizures. J Neuroinflammation 2016; 13(-1-):155. >>> Antibody, CX3CR1; saline; CSF/CNS (ventricle); rat; Controls were Electrode- and cannulae-implanted nonstimulated rats; animal info (Adult male Sprague Dawley rats, 200-250 g); functionality of mp verified by EEG; functionality of mp verified by EEG; brain tissue distribution; Cannula placement verified via expression of antibody; Dose (1 mm posterior and 1.5 mm lateral to the bregma and 3.5 mm ventral to the flat skull position (with the bregma as reference)); Interesting“Our results are the first evidence that epileptic seizures induce an immune response in the retina. It has a potential to become a novel non-invasive tool for detecting brain inflammation through the eyes” pg. 1;.

16233 Rabinovich-Toidman, P., Rabinovich-Nikitin, I., Ezra, A., Barbiro, B., Fogel, H., Slutsky, I., Solomon, B. Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS. PLoS One 2015; 10(-11-):e0143420. >>> Antibody, monoclonal, BBS; CSF/CNS (right lateral ventricle); mice; 2006; Controls received mp w/ isotype-matched non relevant MAb; animal info (male Hemizygous B6SJLTgN (SOD1G93A) 1 Gur mice); brain infusion cannula used; neurodegenerative (ALS); immunology; antibodies infused; MAb aka Monoclonal antibody; Ketamine and Xylazine anesthesia; Dose (1.5 mg/mL); Brain coordinates; l-2mm [Bregma] in the anterio-posterior direction, 2.8mm in mediolateral direction and 3mm depth.

16146 Okizaki, S., Ito, Y., Hosono, K., Oba, K., Ohkubo, H., Kojo, K., Nishizawa, N., Shibuya, M., Shichiri, M., Majima, M. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1beta by Recruited Macrophages. Am J Pathol 2016; 186(-6-):1481-98. >>> Placenta growth factor, recombinant human; antibody, interleukin-1B; PBS; SC; Mice; 1007D; Controls received mp w/ vehicle or control antibody; animal info (male, C57BL6, 8 weeks old, STZ); immunology; diabetes; Dose (PlGF 10 ug/mouse; anti-IL-1B 1 ug/day);.

16012 Ghadge, G. D., Pavlovic, J. D., Koduvayur, S. P., Kay, B. K., Roos, R. P. Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1. Neurobiol Dis 2013; 56(--):74-8. >>> antibody, monoclonal anti-SOD1; CSF/CNS (Intraventricular); mice; animal info: FALS transgenic mice; anti SOD1 monoclonal antibody; neurodegenerative (Amyotrophic Lateral Sclerosis); paper does not mention ALZET much, or pump model;.

15883 Sato, Y., Sato, W., Maruyama, S., Wilcox, C. S., Falck, J. R., Masuda, T., Kosugi, T., Kojima, H., Maeda, K., Furuhashi, K., Ando, M., Imai, E., Matsuo, S., Kadomatsu, K. Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. J Am Soc Nephrol 2015; 26(-8-):1806-15. >>> Antibody, anti-MK; Mice; 1007D; Controls received mp w/ control antibody; animal info (male, Mdk +/-, 10-14 weeks old, 25-35g); cardiovascular; bp measured using radiotelemetry; Dose (5.0 ug/hr);.

15813 Regina R. Reimann, Tiziana Sonati, Simone Hornemann, Uli S. Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi  PLoS Pathog 2016; 12(-1-):1-19. >>> Antibody, 31C6; antibody, POM1; PBS; CSF/CNS; Mice; 2004; animal info (BL6.129-Prnp); post op. care (SC injections of buprenorphinum, funixin, and 5% glucose; Sulfadoxinum and sugar were added into water for 1 week post op); MRI; pumps primed in 37C PBS for 24 hours; used PEEK tubing;.

15767 Mathieu Gravel, Louis-Charles Be´land, Genevie`ve Soucy, Essam Abdelhamid, Reza Rahimian, Claude Gravel, Jasna Kriz  The Journal of Neuroscience 2016; 36(-3-):1031-1048. >>> Antibody, Interleukin-10 receptor; Antibody, Interleukin-10 receptor; Mice; 2006; Controls received mp w/ saline; animal info (SOD1 G93A, 60 days old); neurodegenerative (amyotrophic lateral sclerosis); behavioral testing (hindlimb relfex); pumps primed overnight in 37C saline; used dental cement; Dose (3.6 ug/day);.

15752 Luis M. Craveiro,, Oliver Weinmann,, Bernd Roschitzki,, Roman R. Gonzenbach,, Björn Zörner,, Laura Montani,, Benjamin K. Yee,, Joram Feldon,, RomanWilli,, Martin E. Schwaba,  Experimental Neurology 2013; (-250-):52-68. >>> Antibody, anti-Nogo-A 11C7; PBS; CSF/CNS (intrathecal); Rat; 2ML2; 2ML4; Controls received mp w/ control antibody or PBS; animal info (male, Long Evans, 2-3 months old, 300g); post op. care (Rimadyl 5 mg/kg injection SC, Baytril 5 mg/kg injection SC for 72 hours at 12 hour intervals); behavioral testing (locomotor activity, anxiety, open field test, elevated plus maze); toxicology;“This procedure ensured antibody delivery into the CSF at a constant flow rate for 2 or 4 weeks.” pg 53;.

15746 Jia Chen, Cheng-Ren Li, Heng Yang, Juan Liu, Tao Zhang, Shu-Sheng Jiao, Yan-Jiang Wang, Zhi-Qiang Xu  NEUROTOXICITY RESEARCH 2016; (-29-):47-53. >>> Brain-derived neurotrophic factor, pro; antibody brain-derived neurotrophic factor, anti-pro;; BSA; CSF/CNS (hippocampus); Mice; 1002; Controls received mp w/ vehicle; Controls received mp w/ vehicle; neurodegenerative (Alzheimer's Disease); behavioral testing (morris water maze); Cannula placement verified postmortem;.

15143 Wilson, C.L., Jurk, D., Fullard, N., Banks, P., Page, A., Luli, S., Elsharkawy, A.M., Gieling, R.G., Chakraborty, J.B., Fox, C., Richardson, C., Callaghan, K., Blair, G.E., Fox, N., Lagnado, A., Passos, J.F., Moore, A.J., Smith, G.R., Tiniakos, D.G., Mann, J., Oakley, F., Mann, D.A., Oakley, F. NFkappaB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nature Communications 2015; 6(--):U1-U13. >>> Antibody, Ly6G; immunoglobulin G2a, rat; SC; Mice; 2004; Animal info (male, DEN-injured nfkb1 -/- or WT, 22 weeks old); cancer (hepatocellular carcinoma);.

15066 Prasad, S., Gaedicke, S., Machein, M., Mittler, G., Braun, F., Hettich, M., Firat, E., Klingner, K., Schueler, J., Wider, D., Waesch, R.M., Herold-Mende, C., Elsaesser-Beile, U., Niedermann, G., Niedermann, G. Effective Eradication of Glioblastoma Stem Cells by Local Application of an AC133/CD133-Specific T-cell-Engaging Antibody and CD8 T Cells. CANCER RESEARCH 2015; 75(--):2166-2176. >>> Antibody, AC133xCD3 bispecific; PBS; CSF/CNS; Mice (nude); 1007D; Controls received mp w/ control antibody; animal info (NMR I nude, 6-8 weeks old); ALZET brain infusion kit 3 used; cancer (glioblastoma multiforme); immunology; cyanoacrylate adhesive;.

14977 Ito, W.D., Lund, N., Zhang, Z.Y., Buck, F., Lellek, H., Horst, A., Machens, H.G., Schunkert, H., Schaper, W., Meinertz, T., Ito, W.D. Activation of Cell Surface Bound 20S Proteasome Inhibits Vascular Cell Growth and Arteriogenesis. BIOMED RESEARCH INTERNATIONAL 2015; ;(--):U1-U11. >>> Antibody, CTA 157-2; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200g); cardiovascular;.

14884 Cherry, J.D., Olschowka, J.A., O'Banion, M.K., O'Banion, M.K. Arginase 1+ microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U14-U26. >>> Antibody, interleukin-4Ra; CSF/CNS (hippocampus); Mice; 1004; Controls received mp w/ control antibody; animal info (APPswe/SP1dE9, 7-5 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); immunology; pumps primed 48 hours in 37C saline;.

14818 Ali, I., Chugh, D., Ekdahl, C.T., Ekdahl, C.T. Role of fractalkine-CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain. NEUROBIOLOGY OF DISEASE 2015; 74(--):194-203. >>> Antibody, CX3CR1 rabbit; fractalkine, recombinant rat; PBS; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, adult, 200-250g); ALZET brain infusion kit 1 used;.

14538 Zoerner, B., Bachmann, L.C., Filli, L., Kapitza, S., Gullo, M., Bolliger, M., Starkey, M.L., Rothlisberger, M., Gonzenbach, R.R., Schwab, M.E., Zoerner, B. Chasing central nervous system plasticity: the brainstem's contribution to locomotor recovery in rats with spinal cord injury. Brain 2014; 137(--):1716-1732. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML2; Animal info (female, Lewis, 10 weeks old, 200-250g); spinal cord injury; behavioral testing (locomotor tasks);.

14530 Zhang, H., Verkman, A.S., Verkman, A.S. Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. Journal of Autoimmunity 2014; 53(--):67-77. >>> Antibody, neuromyelitis optica; PBS; CSF/CNS; Mice; 1003D; Controls received mp w/ control IgG; animal info (BALB/c an CD59 -/-, 8-10 weeks old); neurodegenerative (neuromyelitis optica); behavioral testing (motor function);.

14441 Tilahun, A.Y., Chowdhary, V.R., David, C.S., Rajagopalan, G., Rajagopalan, G. Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome. Journal of Immunology 2014; 193(--):2919-2930. >>> Interleukin-2, murine; antibody, anti-interleukin-2; PBS; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (HLA-DR3); comparison of injection vs mp; immunology;.

14436 Tavares, E., Maldonado, R., Minano, F.J., Minano, F.J. Immunoneutralization of Endogenous Aminoprocalcitonin Attenuates Sepsis-Induced Acute Lung Injury and Mortality in Rats. American Journal of Pathology 2014; 184(--):3069-3083. >>> Antibody, anti-aminoprocalcitonin; Saline; IP; Rat; 2001D; Controls received mp w/ control antibody; animal info (male, Wistar, 280-300g); tissue perfusion (peritoneum); immunology; peptides; Catheter used to cannulate peritoneum;.

14376 Rygh, C.B., Wang, J., Thuen, M., Navarro, A.G., Huuse, E.M., Thorsen, F., Poli, A., Zimmer, J., Haraldseth, O., Lie, S.A., Enger, P.O., Chekenya, M., Rygh, C.B. Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLoS One 2014; 9(--):U981-U992. >>> Antibody, mAb9.2.27; PEG; CSF/CNS; Rat (nude); 2001D; Controls received mp w/ vehicle; animal info (rnu/rnu, 8-10 weeks old); 24% PEG used; cancer (glioblastoma);.

14364 Reshef, R., Kreisel, T., Kay, D.B., Yirmiya, R., Yirmiya, R. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. BRAIN BEHAVIOR AND IMMUNITY 2014; 41(--):239-250. >>> Antibody, CX3CR1; CSF, artificial; CSF/CNS; Mice; Controls received mp w/ vehicle; animal info (WT, adult); vehicle pumps replaced after 7 days with pumps filled with test agent; behavioral testing (Morris Water Maze; contextual and auditory-cued fear conditioning; olfactory memory); used guide cannula; used three stainless-steel screws and dental cement;.

14339 Pajer, K., Feichtinger, G.A., Marton, G., Sabitzer, S., Klein, D., Redl, H., Nogradi, A., Nogradi, A. Cytokine signaling by grafted neuroectodermal stem cells rescues motoneurons destined to die. Experimental Neurology 2014; 261(--):180-189. >>> Antibody, anti-interleukin-1a; antibody, anti-interleukin-6; antibody, tumor necrosis factor-alpha; antibody, macrophage inflammatory protein-1 alpha; CSF/CNS (intrathecal); Rat; 1002; Controls received mp w/ control antibody; animal info (female, Sprague Dawley, adult); functionality of mp verified by decreased activity of targets; used silicone tubing 0.3 mm ID for catheter; catheter was fixed to surrounding muscle with 8-0 sutures; pumps removed after 2 weeks;.

14280 Lin, C.P., Kang, K.H., Lin, T.H., Wu, M.Y., Liou, H.C., Chuang, W.J., Sun, W.Z., Fu, W.M., Fu, W.M. Role of Spinal CXCL1 (GROalpha) in Opioid Tolerance A Human-to-rodent Translational Study. Anesthesiology 2015; 122(--):666-676. >>> CXCL1; antibody, CXCL1; CXCR2 antileukine hexapeptide; morphine; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (male, Sprague Dawley, 250-275g, adult); behavioral testing (tail flick response); dependence; used PE10 intrathecal catheter tubing;.

14717 Dai, C.L., Chen, X., Kazim, S.F., Liu, F., Gong, C.X., Grundke-Iqbal, I., Iqbal, K., Iqbal, K. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of Neural Transmission 2015; 122(--):607-617. >>> Antibody, HJ9.4; antibody, HJ8.5; antibody, HJ9.3; CSF/CNS; Mice (transgenic); Animal info (P301S tau transgenic, 6 months old); neurodegenerative (Alzheimer's disease); behavioral testing (fear conditioning); pumps mentioned in intro;.

14690 Chelakkot-Govindalayathil, A.L., Mifuji-Moroka, R., Alessandro-Gabazza, C.N., Toda, M., Matsuda, Y., Gil-Bernabe, P., Roeen, Z., Yasuma, T., Yano, Y., Gabazza, E.C., Iwasa, M., Takei, Y., Gabazza, E.C. Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2015; 13(--):142-154. >>> Antibody, Protein S PS-IgG; SC; Mice; 1003D; Controls received mp w/ control antibody; animal info (male, C57BL6, 22-25g); immunology;.

14592 Smith, E.S., Jonason, A., Reilly, C., Veeraraghavan, J., Fisher, T., Doherty, M., Klimatcheva, E., Mallow, C., Cornelius, C., Leonard, J.E., Marchi, N., Janigro, D., Argaw, A.T., Pham, T., Seils, J., Bussler, H., Torno, S., Kirk, R., Howell, A., Evans, E.E., Paris, M., Bowers, W.J., John, G., Zauderer, M., Zauderer, M. SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease. NEUROBIOLOGY OF DISEASE 2015; 73(--):254-268. >>> Antibody, anti-SEMA 4D, monoclonal; CSF/CNS (intrathecal, subarachnoid space); Rat; 2002; Control animals received mp w/ control IgG; animal info (Sprague Dawley, male, 8 wks old).

14586 Orostica, M.L., Lopez, J., Zuniga, L.M., Utz, D., Diaz, P., Reuquen, P., Parada-Bustamante, A., Cardenas, H., Orihuela, P.A., Orihuela, P.A. Mating Decreases Plasma Levels of TGFbeta1 and Regulates Myosalpinx Expression of TGFbeta1/TGFBR3 in the Rat. MOLECULAR REPRODUCTION AND DEVELOPMENT 2014; 81(--):1053-1061. >>> Antibody, TGF beta 1; Saline; SC; Rat; 2ML1; Control animals received mp w/ vehicle; animal info (Sprague Dawley, 200-260 g).

13956 Wyss, A.F., Hamadjida, A., Savidan, J., Liu, Y., Bashir, S., Mir, A., Schwab, M.E., Rouiller, E.M., Belhaj-Saif, A. Long-term motor cortical map changes following unilateral lesion of the hand representation in the motor cortex in macaque monkeys showing functional recovery of hand functions. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 2013; 31(-6-):733-760. >>> Antibody, anti-Nogo-A 11C7; CNS/CSF; CNS/CSF (intrathecal); Monkey (macaque); 2ML2; Controls received no pump treatment; animal info (macaca fascicularis, 1 female, 7 male, 4-6 years old, 3.5-6.5 kg); Multiple pumps per animal (2); behavioral testing (modified Brinkman board task, rotative Brainkman board task, Brinkman box task); One pump delivered IT, other delivered CSF/CNS using catheter; no cannula used, see pg.741; pumps removed after 4 weeks; used antibody concentration of 3 mg/ml;.

13950 Yegla, B., Parikh, V. EFFECTS OF SUSTAINED PRONGF BLOCKADE ON ATTENTIONAL CAPACITIES IN AGED RATS WITH COMPROMISED CHOLINERGIC SYSTEM. Neuroscience 2014; 261(-;-):118-132. >>> Antibody, pro-nerve growth factor; PBS; CSF/CNS; Rat; 1004; Controls received mp w/ vehicle; animal info (male, Wistar, 23 months old); ALZET brain infusion kit used; good methods (cannula placement pg.124, fig.2); post op. care (triple antibiotic cream on wound; Baytril injected; buprenorphine); behavioral testing (sustained attention task, performance measures); Cannula placement verified via Nissl staining; used dental cement and bone screws; pumps and cannula removed after 4 weeks;.

13948 Zemmar, A., Weinmann, O., Kellner, Y., Yu, X.Z., Vicente, R., Gullo, M., Kasper, H., Lussi, K., Ristic, Z., Luft, A.R., Rioult-Pedotti, M., Zuo, Y., Zagrebelsky, M., Schwab, M.E., Zemmar, A. Neutralization of Nogo-A Enhances Synaptic Plasticity in the Rodent Motor Cortex and Improves Motor Learning in Vivo. Journal of Neuroscience 2014; 34(--):8685-8698. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML1; Controls received sham surgery; animal info (male, Sprague Dawley, 5-6 weeks old, 190-220g); functionality of mp verified by immunohistochemistry and Western blotting; behavioral testing (motor skill task); brain tissue distribution; learning;.

13923 Sawada, H., Saito, T., Nickel, N.P., Alastalo, T.P., Glotzbach, J.P., Chan, R., Haghighat, L., Fuchs, G., Januszyk, M., Cao, A.Q., Lai, Y.J., Perez, V.D., Kim, Y.M., Wang, L.L., Chen, P.I., Spiekerkoetter, E., Mitani, Y., Gurtner, G.C., Sarnow, P., Rabinovitch, M. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. Journal of Experimental Medicine 2013; 211(-2-):263-280. >>> Antibody, rat anti-mouse IgG macrophage colony-stimulating factor; SC; Mice; 1002; Controls received mp w/ control antibody IgG2a; animal info (C57BL6, 8 weeks old); cardiovascular; immunology;.

13904 Porlan, E., Marti-Prado, B., Morante-Redolat, J.M., Consiglio, A., Delgado, A.C., Kypta, R., Lopez-Otin, C., Kirstein, M., Farinas, I., Farinas, I. MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. NATURE CELL BIOLOGY 2014; 16(--):629-+. >>> Antibody, N-cadherin extracellular domain; AraC; CSF/CNS; Mice; Controls received mp w/ control antibody; animal info (Mmp24 knockout); good methods (picture of pump infusion pg.635); AraC pumps removed after 6 days;.

13899 Picarda, E., Bezie, S., Venturi, V., Echasserieau, K., Merieau, E., Delhumeau, A., Renaudin, K., Brouard, S., Bernardeau, K., Anegon, I., Guillonneau, C., Guillonneau, C. MHC-derived allopeptide activates TCR-biased CD8(+) Tregs and suppresses organ rejection. Journal of Clinical Investigation 2014; 124(--):2497-2512. >>> DU51; antibody, anti-MHC-1; antibody, anti-CD8; DMSO; PBS; IP; Rat; Controls received mp w/ control peptide; animal info (male, LEW.1W and LEW.1A); pumps replaced every 7 days; 0.4% DMSO used; peptides;"... to improve the efficacy of the treatment and because such small peptides are rapidly eliminated from the recipient's body, we tested mini-osmotic pumps with a constant i.p. delivery of 20.8ìg/hour of peptide for 28 days, starting on day 7 before transplantation."pg 2507;.

13898 Pettersson, L.M.E., Geremia, N.M., Ying, Z.X., Verge, V.M.K., Pettersson, L.M.E. Injury-Associated PACAP Expression in Rat Sensory and Motor Neurons Is Induced by Endogenous BDNF. PLoS One 2014; 9(--):U629-U640. >>> Antibody, brain-derived neurotrophic factor; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ control IgG; animal info (male, Wistar, 250-300tg); post op. care (buprenorphine 0.05-0.1 mg/kg SC); peripheral nerve injury;.

13857 Macas, J., Ku, M.C., Nern, C., Xu, Y.Z., Buehler, H., Remke, M., Synowitz, M., Franz, K., Seifert, V., Plate, K.H., Kettenmann, H., Glass, R., Momma, S., Momma, S. Generation of Neuronal Progenitor Cells in Response to Tumors in the Human Brain. Stem Cells 2014; 32(--):244-257. >>> Antibody, anti-VEGFR-2; CSF/CNS; Mice; 1007D; Controls received mp w/ control antibody; animal info (C57BL6, 8 weeks old); cancer (brain tumor);.

13782 Giacobini, P., Parkash, J., Campagne, C., Messina, A., Casoni, F., Vanacker, C., Langlet, F., Hobo, B., Cagnoni, G., Gallet, S., Hanchate, N.K., Mazur, D., Taniguchi, M., Mazzone, M., Verhaagen, J., Ciofi, P., Bouret, S.G., Tamagnone, L., Prevot, V. Brain Endothelial Cells Control Fertility through Ovarian-SteroidûDependent Release of Semaphorin 3A. PLOS BIOLOGY 2014; 12(-3-):U102-U119. >>> Antibody, neuropilin-1; PBS, Dulbecco's; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 190-200g); Neuropilin-1 aka Nrp1; used Plastics One cannula; pumps primed overnight in 37C saline;.

13643 Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda, K., Naka, T., Yamashita, T. ifn-gamma-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death&Disease 2013; 4(-;-):U100-U108. >>> Antibody, anti interleukin-10; CSF/CNS; Mice; 1007D; Controls received mp w/ control IgG; animal info (female, C57BL6, 7-9 weeks old); ALZET brain infusion kit 3 used; spinal cord injury; behavioral testing (open field, grid walk, inclined plane);.

13605 Lindau, N.T., Baenninger, B.J., Gullo, M., Good, N.A., Bachmann, L.C., Starkey, M.L., Schwab, M.E. Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy. Brain 2014; 137(-;-):739-756. >>> Antibody, mouse monocolonal anti-Nogo-A 11C7; uridine, anti-bromodeoxy; CSF/CNS (intrathecal); Rat; 2ML2; Controls received mp w/control antibody; animal info (female, Long Evans, 3-7 months, 230-400g); ischemia (photothrombic); post op. care (Rimadyl 2.5mg/kg, Baytril 5mg/kg for 3 days; mannitol 20% injection 17 mg/kg; heating pad for 24h); behavioral testing (pellet grasping); pump and catheter removed after 2 weeks; used 32 gauge intrathecal catheter;.

13485 Donegan, J.J., Girotti, M., Weinberg, M.S., Morilak, D.A. A Novel Role for Brain Interleukin-6: Facilitation of Cognitive Flexibility in Rat Orbitofrontal Cortex. Journal of Neuroscience 2014; 34(-3-):953-962. >>> Antibody, anti-IL-6; Saline; CSF/CNS (orbitofrontal cortex); Rat; 1004; Controls received mp w/ goat IgG; animal info (male, Sprague Dawley, adult, 220-240g); behavioral testing (learning); tissue perfusion (orbitofrontal cortex); immunology; Cannula placement verified via histology; Used dual-injection, osmotic pump compatible cannulae from Plastics One.

13480 Asavapanumas, N., Ratelade, J., Papadopoulos, M.C., Bennett, J.L., Levin, M.H., Verkman, A.S. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. Journal of Neuroinflammation 2014; 11(-;-):U1-U11. >>> Antibody, rAb-53; complement, human; CSF/CNS (optic chiasm); Mice; 1003D; Controls received mp w/ non-NMO control IgG and complement; animal info (AQP4+/+ and AQP4-/-, 8-10 weeks old); tissue perfusion (optic chiasm); immunology; Cannula placement verified via Evan's blue dye; rAb-53 aka NMO-IgG;.

13467 Poli, A., Wang, J., Domingues, O., Planaguma, J., Yan, T., Rygh, C.B., Skaftnesmo, K.O., Thorsen, F., McCormack, E., Hentges, F., Pedersen, P.H., Zimmer, J., Enger, P.O., Chekenya, M. Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. ONCOTARGET 2013; 4(-9-):1527-1546. >>> Antibody, mAB9.2.27; PEG; CSF/CNS; Rat (nude); 2001D; Controls received mp w/ IgG2a control isotype; animal info (Hsd:RH-Foxn1 rnu, 8-10 weeks old); 24% PEG used; cancer (U251-NG2 tumors, glioblastoma); immunology;.

13419 Zhao, R.R., Andrews, M.R., Wang, D.F., Warren, P., Gullo, M., Schnell, L., Schwab, M.E., Fawcett, J.W. Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. European Journal of Neuroscience 2013; 38(-6-):2946-2961. >>> Antibody, anti-Nogo-A 11C7; CSF/CNS (intrathecal); Mice; 2ML2; Controls received mp w/ control antibody (anti cyclosporin A); animal info (male, Lister hooded, adult, 150-200g); good methods (pg 2947, schematic of positioning of pumps p2948); spinal cord injury; neurodegenerative (spinal cord injury); behavioral testing (staircase task, ladder walking, gait analysis, grip strength, heat sensation, von Frey hair test); used 32 gauge catheter from ReCathco.

13395 Kiyomoto, M., Shinoda, M., Okada-Ogawa, A., Noma, N., Shibuta, K., Tsuboi, Y., Sessle, B.J., Imamura, Y., Iwata, K. Fractalkine Signaling in Microglia Contributes to Ectopic Orofacial Pain following Trapezius Muscle Inflammation. Journal of Neuroscience 2013; 33(-18-):7667-7680. >>> Antibody, anti CX3CRI; Fractalkine; Antibody, anti interleukin-beta; Saline; CSF/CNS (cisterna magna); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 210-260g); post op. care (benzyl penicillin potassium, 20000U); behavioral testing (Rota-rod performance, Water tap reaching performance); immunology; peptides.

13355 Brazda, N., Voss, C., Estrada, V., Lodin, H., Weinrich, N., Seide, K., Mueller, J., Mueller, H.W. A mechanical microconnector system for restoration of tissue continuity and long-term drug application into the injured spinal cord. Biomaterials 2013; 34(-38-):10056-10064. >>> Antibody, human IgG; Saline; CSF/CNS (spinal cord, intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (Female, Wistar, 200-230g); spinal cord injury; post op. care (Baytril for one week, manual bladder emptying twice per day); behavioral testing (locomotor behavior); tissue perfusion (spinal cord); pump attached to mechanical microconnector system (mMS).

13258 Sun, F., Mao, X.O., Xie, L., Ding, M.P., Shao, B., Jin, K.L. Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia. AGING CELL 2013; 12(-6-):978-987. >>> Antibody, notch1-activating; Jagged 1-Fc-anti-Fc complex; CSF, artificial; CSF/CNS; Rat; 1003D; Controls received mp w/ aCSF; animal info (male, Fisher); behavioral testing (ladder rung walking test, limb placing test, elevated body swing test, cylinder test); Neuroscience paper; ischemia.

13253 Girotti, M., Donegan, J.J., Morilak, D.A. Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress. Psychoneuroendocrinology 2013; 38(-7-):1158-1169. >>> Antibody, interleukin-6; SC; Rat; 1004; Controls received mp w/ IgG; immunology; animal info (male, 220-240g); functionality of mp verified by IL-6 protein levels (western blot, high-sensitivity ELISA).

13220 Tohda, C., Lee, Y.A., Goto, Y., Nemere, I. Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D(3)-MARRS. SCIENTIFIC REPORTS 2013; 3(-;-):U24-U31. >>> Antibody, anti-1.25D3-MARRS; CSF, artificial; SC; Mice; 1007D; Animal info (6 weeks old, ddY, male); cyanoacrylate adhesive; Brain infusion kit (3) used; behavioral testing (object recognition memory test, open field test); 1,25D3-MARRS has many synonyms including Pdia3, ERp57, and GRP58;.

13212 Seo, J.H., Yu, J.H., Suh, H., Kim, M.S., Cho, S.R. Fibroblast Growth Factor-2 Induced by Enriched Environment Enhances Angiogenesis and Motor Function in Chronic Hypoxic-Ischemic Brain Injury. PLoS One 2013; 8(-9-):U184-U194. >>> Antibody, fibroblast growth factor-2;; CSF/CNS; Mice; 1002; Animal Info. (Hypoxic-ischemic mice, 6 weeks old, CD-1); Pumps replaced (every 2 weeks); Ischemia (hypoxic ischemic brain injury); Behavior testing (Rotarod performance, forelimb-use asymmetry test, grip strength test).

13185 Broering, T.J., Wang, H.Y., Boatright, N.K., Wang, Y., Baptista, K., Shayan, G., Garrity, K.A., Kayatekin, C., Bosco, D.A., Matthews, C.R., Ambrosino, D.M., Xu, Z.S., Babcock, G.J. Identification of Human Monoclonal Antibodies Specific for Human SOD1 Recognizing Distinct Epitopes and Forms of SOD1. PLoS One 2013; 8(-4-):U413-U425. >>> Antibody, monoclonal, human; CSF/CNS; Mice; 2006; Animal info (>20g, 65-115 days old); functionality of mp verified by measuring residual volume; measurement of tissue and serum HuMabs levels; pumps replaced every 50 days; good methods; long-term study.

13158 Gil, S.Y., Youn, B.S., Byun, K., Huang, H., Namkoong, C., Jang, P.G., Lee, J.Y., Jo, Y.H., Kang, G.M., Kim, H.K., Shin, M.S., Pietrzik, C.U., Lee, B., Kim, Y.B., Kim, M.S. Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nature Communications 2013; 4(-;-):U610-U618. >>> Antibody, anti clusterin; Saline, dansylcadaverine; DMS; SC; Mice; Controls received mp w/ anti rabbiti IgG, saline; animal info (male C57BL/6).

13128 Petrosyan, H.A., Hunanyan, A.S., Alessi, V., Schnell, L., Levine, J., Arvanian, V.L. Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats. Journal of Neuroscience 2013; 33(-9-):4032-4043. >>> Antibody, 69, mouse monoclonal; antibody, 147, mouse monoclonal; CSF/CNS (intrathecal); Rat; 2ML2; Control animals received mp w/ control antibody; animal info (Sprague Dawley, female, wks old, 210 g); spinal cord injury; post op care (baytril, buprenorphine).

13053 Carbonell, W.S., Delay, M., Jahangiri, A., Park, C.C., Aghi, M.K. beta1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma. Cancer Research 2013; 73(-10-):3145-3154. >>> Antibody, OS2966; SC; Mice; 1004; Control animals received mp w/ immunoglobulin G; animal info (female, athymic, 5-8 wks old); OS2966 is a beta 1 antibody; cancer (glioblastoma); dose-response (Fig. 6); mp were used to block B1 integrin, and found that this can inhibit the ability of tumor cells to bind a broad spectrum of ECM ligands like fibronectin, collagen IV, and laminin.

12973 Ribeiro-Resende, V.T., Carrier-Ruiz, A., Lemes, R.M.R., Reis, R.A.M., Mendez-Otero, R. Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system. Molecular Neurodegeneration 2012; 7(-;-):U1-U17. >>> Antibody, Fibroblast growth factor-2, mouse, monoclonal; CSF/CNS (sciatic nerve); Rat; 2002; Animal info (male, Lister Hooded, 3 mo old).

12933 Rabinovich-Nikitin, I., Rakover, I.S., Becker, M., Solomon, B. Beneficial Effect of Antibodies against beta- Secretase Cleavage Site of App on Alzheimer's-Like Pathology in Triple-Transgenic Mice. PLoS One 2012; 7(-10-):U429-U437. >>> Antibody, monoclonal, BBS1; CSF, artificial; CSF/CNS; Mice (transgenic); 2004; Control animals received mp w/ control antibody; animal info (17 mo old, 3xTg-AD); neurodegenerative (Alzheimer's disease).

12921 Cho, G.S., Lee, J.C., Ju, C., Kim, C., Kim, W.K. N-Methyl-D-aspartate receptor antagonists memantine and MK-801 attenuate the cerebral infarct accelerated by intracorpus callosum injection of lipopolysaccharides. Neuroscience Letters 2013; 538(-;-):9-14. >>> Antibody, interleukin-1 beta; CSF/CNS; Rat; 1003D; Animal info (Sprague Dawley, male, 260-270 g); ischemia.

12713 You, J., Hong, S.Q., Zhang, M.Y., Zhao, H.L., Liu, T.Z., Zhou, H.L., Cai, Y.Q., Xu, Z.M., Guo, Y., Jiang, X.D., Xu, R.X. Passive immunization with tenascin-R (TN-R) polyclonal antibody promotes axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience Letters 2012; 525(-2-):129-134. >>> Antibody, TN-R polyclonal; SC; Rat; 2ML4; Control animals received mp w/ rabbit control serum; animal info (Sprague Dawley, female, 12 wks old, 250-320 g, adult); spinal cord injury.

12710 Doyle, F., Cardoso, F., Lopes, L., Mendes, M., Dias, F., Cruz, L., Tavares, R., Camargos, A., Carneiro, M., as-Lopes, C., Chavez-Olortegui, C. Infusion of Sydenham's chorea antibodies in striatum with up-regulated dopaminergic receptors: A pilot study to investigate the potential of SC antibodies to increase dopaminergic activity. Neuroscience Letters 2012; 523(-2-):186-189. >>> Antibody, Sydenham's chorea; CSF/CNS (striatum); Rat; Control animals received mp w/ control antibodies; animal info (Wistar, male, adult, 290-360 g); 0.5 ul/hr rate of infusion.

12701 Fainstein, N., Cohen, M.E., Ben-Hur, T. Time associated decline in neurotrophic properties of neural stem cell grafts render them dependent on brain region-specific environmental support. NEUROBIOLOGY OF DISEASE 2013; 49(-;-):41-48. >>> Antibody, anti-beta 1 integrin; CSF/CNS (striatum); Mice; Control animals received mp w/ isotype control; animal info (C57BL/6, female).

12695 vom Berg, J., Prokop, S., Miller, K.R., Obst, J., Kaelin, R.E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C.G., Peters, O., Winter, Y., Becher, B., Heppner, F.L. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nature Medicine 2012; 18(-12-):1812-U229. >>> Antibody, P40; antibody, 2A3; CSF/CNS; Mice; Animal info (APPPS1); long-term study; pumps replaced after 4 weeks; neurodegenerative (Alzheimer's disease).

12616 Kokovay, E., Wang, Y., Kusek, G., Wurster, R., Lederman, P., Lowry, N., Shen, Q., Temple, S. VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression. Cell Stem Cell 2012; 11(-2-):220-230. >>> Antibody, VCAM1, rat anti-mouse; CSF, artificial; CSF/CNS; Mice; 1007D; Control animals received mp w/ control antibody; animal info (2-3 mo old, Swiss Webster, hGFAF-GFP transgenic).

12347 Jung, H.K., Ryu, H.J., Kim, M.J., Kim, W.I., Choi, H.K., Choi, H.C., Song, H.K., Jo, S.M., Kang, T.C. Interleukin-18 attenuates disruption of brain-blood barrier induced by status epilepticus within the rat piriform cortex in interferon-gamma independent pathway. Brain Research 2012; 1447(-;-):126-134. >>> Interleukin-18; antibody, anti-rat, IFN gamma; Saline; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 7 wks old); ALZET brain infusion kit 1 used.

 

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What researchers are saying...

“The implanted pumps offered an advantageous alternative to repeated injections. During drug delivery, no external connection was required, and rats were untethered and unrestrained, thereby minimizing animal handling stress” Zhang et al., Journal of Neurophysiology 2000;84:798-805.