References on the Administration of ACTH Using ALZET^® Osmotic Pumps

P9033 Karpac,J., Czyzewska,K., Kern,A., Brush,R.S., Anderson,R.E., Hochgeschwender,U. Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 295(-2-):E446-E455. >>> ACTH (1-24); PBS; BSA; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; replacement therapy (corticosterone); animal info (POMC wt, hetero, mut, male, female).

P8189 Estivariz,F.E., Iturriza,F., McLean,C., Hope,J., Lowry,P.J. Stimulation of adrenal mitogenesis by N-terminal proopiocortin peptides. Nature 1982; 297(-5865-):419-422. >>> ACTH (1-24); pro-opiocortin (1-28), N-;pro-opiocortin (1-76), N-; Acetic acid; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (female, Sprague-Dawley, 10 weeks old); human pituitary glycopeptide N-POC.

P8156 Lowry,P.J., Silas,L., McLean,C., Linton,E.A., Estivariz,F.E. Pro-gamma-melanocyte-stimulating hormone cleavage in adrenal gland undergoing compensatory growth. Nature 1983; 306(--):70-73. >>> Antiserum, anti-ACTH (4-10); antiserum, anti-proopiocortin (1-76), N-; antiserum, anti-proopiocortin (51-74); serum, rabbit; antiserum, anti-proopiocortin (1-28), N-; SC; IP; Rat; 2001; 72 hours; Controls received mp w/ normal rabbit serum; animal info (female, Wistar, 5 weeks old).

P7970 Mumma,J.O., Thaxton,J.P., Vizzier-Thaxton,Y., Dodson,W.L. Physiological stress in laying hens. POULTRY SCIENCE 2006; 85(-4-):761-769. >>> ACTH; Saline; SC; Bird (laying hens); 2001; 7 days; Controls received mp w/ vehicle; animal info (single comb, white leghorn, 36-65 weeks old).

P6993 Thomas,M., Keramidas,M., Monchaux,E., Feige,J.J. Dual hormonal regulation of endocrine tissue mass and vasculature by adrenocorticotropin in the adrenal cortex. Endocrinology 2004; 145(-9-):4320-4329. >>> Dexamethasone; ACTH (1-39), human; Cyclodextrin; SC; Mice; 2002; 1-14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma ACTH and corticosterone levels; multiple pumps per animal (2).

P5768 Puvadolpirod,S., Thaxton,J.P. Model of physiological stress in chickens 3. Temporal patterns of response.. Poult Sci 2000; 79(-3-):377-382. >>> ACTH; SC; Bird (chicken); 2001; 7 days; Peptides; chickens were 6 weeks old; ACTH is adrenocorticotropin.

P4990 Tankson,J.D., Vizzier-Thaxton,Y., Thaxton,J.P., May,J.D., Cameron,J.A. Stress and nutritional quality of broilers. POULTRY SCIENCE 2001; 80(--):1384-1389. >>> ACTH; Saline, avian; SC; bird (chicken); 2001; 7 days; controls received mp w/ vehicle; functionality of mp verified by blood corticosterone levels; peptides; ACTH is adrenocorticotropin.

P4149 King,Y.T., Chen,T.C. Chemical and physical characteristics of chicken livers following adrenocorticotropic hormone-induced stress. J.Food Sci. 1998; 63(-4-):589-591. >>> ACTH, porcine; SC; bird (chicken); 1003D; 24,48 hours; peptides.

P3702 Blair-West,J.R., Denton,D.A., McBurnie,M.I., Weisinger,R.S. The effect of adrenocorticotrophic hormone on water intake in mice. Physiol.Behav. 1996; 60(-4-):1053-1056. >>> ACTH; SC; mice; 2001; 4 or 7 days; controls received mp w/ normal saline; agent also known as synacthen.

P3608 Latour,M.A., Laiche,S.A., Thompson,J.R., Pond,A.L., Peebles,E.D. Continuous infusion of adrenocorticotropin elevates circulating lipoprotein cholesterol and corticosterone concentrations in chickens. Poult.Sci. 1996; 75(--):1428-1432. >>> ACTH; SC; bird (chicken); 2002; no duration posted; controls received no treatment of mp w/ saline; peptides.

P3318 Sawchenko,P.E., Arias,C. Evidence for short-loop feedback effects of ACTH on CRF and vasopressin expression in parvocellular neurosecretory neurons. J.Neuroendocrinology 1995; 7(--):721-731. >>> ACTH; Saline, sterile; SC; rat; 1007D; 7 days; controls received mp w/saline; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P2956 Sangild,P.T., Silver,M., Fowden,A.L., Turvey,A., Foltmann,B. Adrenocortical stimulation of stomach development in the prenatal pig. Biol.Neonate 1994; 65(--):378-389. >>> Cortisol; ACTH(1-24); Saline; SC; pig (fetus); 2001; 6 days; controls received mp with saline; peptides.

P2955 Sangild,P.T., Westrom,B.R., Fowden,A.L., Silver,M. Developmental regulation of the porcine exocrine pancreas by glucocorticoids. J.Pediatr.Gastroenterology and Nutrition 1994; 19(--):204-212. >>> Cortisol; ACTH; Saline; SC; pig (fetus); 2001; 6 days; controls received mp with saline; peptides; no stress: mp was generally well tolerated; the cortisol used was hydrocortisone hemisuccinate.

P2642 Blair-West,J.R., Denton,D.A., McBurnie,M., Tarjan,E., Weisinger,R.S. Influence of adrenal steroid hormones on sodium appetite of balb/c mice. Appetite 1995; 24(--):11-24. >>> ACTH(1-24); Saline; SC; mice; 2001; 7 days; pellets used to deliver several steroids.

P2359 Meseguer,A., Catterall,J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol.and Cellular Endocrin. 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; 7 days; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

P2344 Kowalski,W., Chatterton Jr,R.T. Peripheral and not central suppression of ovarian function during osmotic pump infusion of adrenocorticotropin- (1-24) for one menstrual cycle in the cynomolgus monkey and its partial compensation by a transitory elevation of sex hormone-binding globulin. Endocrinology 1992; 130(-6-):3582-3592. >>> ACTH(1-24); Saline; SC; monkey; 2001; 81-120 days (see chart, pg. 3589); long-term study, pumps replaced after 7 days; stability verified when residual pump solution given i.v. to test bioactivity; peptides; animals received saline mps, ACTH(1-24), then saline mps for 3 menstrual cycles.

P1614 McDaniel,W.F., Davall,E.J., Walker,P.E. ACTH 4-9 analog can retard spatial alternation learning in brain damaged and normal rats. Behav.Neural.Biol. 1989; 52(--):271-278. >>> ACTH; Saline; SC; rat; 2002; 14, 15 days; peptides.

P1381 Estivariz,F.E., Carino,M., Lowry,P.J., Jackson,S. Further evidence that N-terminal pro-opiomelanocortin peptides are involved in adrenal mitogenesis. J.Endocrinol. 1988; 116(--):201-206. >>> ACTH(1-24); Pro-opiomelanocortin(1-28), N-; Pro-opiomelanocortin(1-36), N-; Gelatin; Saline; SC; rat; 2001; 6 days; replacement therapy (hypophysectomy); peptides.

P1329 Rebuffat,P., Belloni,A.S., Malendowicz,L.K., Mazzochi,G., Gottardo,G., Nussdorfer,G.G. Zona glomerulosa morphology and function in streptozotocin-induced diabetic rats. Endocrinology 1988; 123(-2-):949-955. >>> ACTH; Angiotensin II; Captopril; Dexamethasone; Insulin; Saline; SC; rat; 2002; 2 weeks; dose-response (text); functionality of mp verified by plasma levels; replacement t; antihypertensive therapy (streptozotocin-induced diabetes); peptides; antihypertensive.

P1284 Van der Zee,C.E.E.M., Brakkee,J.H., Gispen,W.H. Alpha-MSH and ORG-2766 in peripheral nerve regeneration: different routes of delivery. Eur.J.Pharmacol. 1988; 147(--):351-357. >>> ACTH analog; ORG-2766; Melanocyte-stimulating hormone, a-; Saline; CSF/CNS (sciatic nerve); SC; rat; 2002; 2 weeks; Comparison of oral admin. and admin. by s.c. microspheres; comparison of s.c. injections vs. mp infusion; tissue perfusion (sciatic nerve).

P1019 de Catanzaro,D., Maerz,M.D., Heaven,R.K.B., Wilson,W. Repeated failure of prenatal ACTH administration to alter masculine behavior in mice. Dev.Psychobiol. 1986; 19(-6-):501-510. >>> ACTH(1-24); ACTH, porcine; Saline; SC; mice (pregnant); 2001; 7 days; controls received mp w/vehicle; peptides; comparison of sc injections vs. mp infusion.

P1003 Mann,D.R., Free,C., Nelson,C., Scott,C., Collins,D.C. Mutually independent effects of adrenocorticotropin on luteinizing hormone and testosterone secretion. Endocrinology 1987; 120(--):1542-1550. >>> ACTH(1-24); Corticosterone; Propylene glycol; Saline; SC; rat; 2001; 2ML1; 72/96 hours; controls received mp w/vehicle; peptides; replacement therapy (adrenalectomy).

P0737 Davison,T.F., Freeman,B.M., Rea,J. Effects of continuous treatment with synthetic ACTH(1-24) or corticosterone on immature Gallus domesticus. Gen.Comp.Endocrinol. 1985; 59(--):416-423. >>> ACTH(1-24); SC; bird (chicken); 2002; 14 days; comparison of implantable corticosterone pellets vs. mp infusion of ACTH; peptides.

P0717 Kemppainen,R.J., Thompson,F.N., Lorenz,M.D., Brown,J. Effects of continuous a(1-24)ACTH infusion in the dog. Horm.Metab.Res. 1985; 17(--):58-62. >>> ACTH(1-24), a-; IV (jugular); dog; 2ML1; 2 weeks; mp replaced on day 7; dose-response data; controls received empty mp; mp attached to silastic rubber catheter in jugular vein; peptides.

P0624 Stone,E.A., Slucky,A.V., Platt,J.E., Trullas,R. Reduction of the cyclic adenosine 3',5'-monophosphate response to catecholamines in rat brain slices after repeated restraint stress. J.Pharmacol.Exp.Ther. 1985; 233(-2-):382-388. >>> ACTH(1-24); Epinephrine bitartrate; Norepinephrine bitartrate; Acetic acid; Ascorbic acid; SC; rat; 12 days; mp model not stated; comparison of ACTH sc inject vs. mp infusion; comparison of agents effects; mp functionality pp. 386, 388; acetic acid was vehicle w/ACTH, ascorbic acid was w/NE and EPI; peptides.

P0611 Mann,D.R., Evans,D., Edoimioya,F., Kamel,F., Butterstein,G.M. A detailed examination of the in vivo and in vitro effects of ACTH on gonadotropin secretion in the adult rat. Neuroendocrinology 1985; 40(--):297-302. >>> ACTH(1-24); Saline; CSF/CNS; SC; rat; 2001; 6 days; peptides.

P0559 Shenker,Y., Villareal,J.Z., Sider,R.S., Grekin,R.J. a-Melanocyte-stimulating hormone stimulation of aldosterone secretion in hypophysectomized rats. Endocrinology 1985; 116(-1-):138-141. >>> ACTH(1-24); Dexamethasone disodium phosphate; Melanocyte-stimulating hormone, a-; Thyroxine, l-; SC; rat; 6 days; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0452 Mann,D.R., Blank,M.S., Sridaran,R., Castracane,V.D., Eldridge,C., Collins,D.C. Influence of anti-oestrogens on gonadotrophin secretion in control and ACTH-infused immature rats. Acta Endocrinol. 1984; 105(-3-):308-313. >>> ACTH(1-24); Saline; SC; rat; 2001; 6 days; estrogen antagonists nafoxidine&MER-25 also admin.; peptides.

P0449 Dunlap,N.E., Grizzle,W.E. Golden syrian hamsters: a new experimental model for adrenal compensatory hypertrophy. Endocrinology 1984; 114(-5-):1490-1495. >>> ACTH(1-24); Aldosterone; Dexamethasone; Propylene glycol; Saline; IP; hamster; 3 days; comparison of daily im injec of Dex. vs mp infusion; comparison of agents effects; replacement therapy (adrenalectomy&hypophysect.); agents given alone&in combination; stability of ACTH verified by assay; peptides.

P0446 Grizzle,W.E., Dunlap,N.E. Aldosterone blocks adrenal compensatory hypertrophy in the rat. Am.J.Physiol. 1984; 246(--):E306-E310. >>> ACTH(1-24); Aldosterone; Dexamethasone; Propylene glycol; Saline; IP; rat; 3 days; comparison of im Dexam. injec vs. mp infusion; comparison of agents effects; replacement therapy (adrenalectomy&hypophysec.); stability of ACTH in mp verified; hormones given alone&in combination; states pumping rate was low; peptides.

P0388 Akana,S.F., Shinsako,J., Dallman,M.F. Relationships among adrenal weight, corticosterone, and stimulated adrenocorticotropin levels in rats. Endocrinology 1983; 113(-6-):2226-2231. >>> ACTH(1-24), a-; HCl; Protein standard; Saline; SC; rat; 2001; 60 hours; pumps primed at room temp. before implant; pumps retreived from 1st group and reimplanted in 2nd group of rats; peptides.

P0387 Akana,S.F., Shinsako,J., Dallman,M.F. Drug-induced adrenal hypertrophy provides evidence for reset in the adrenocortical system. Endocrinology 1983; 113(-6-):2232-22237. >>> ACTH(1-24); Saline; SC; rat; 3 and 7 days; peptides.

P0326 Gmerek,D.E., Cowan,A. ACTH(1-24) and RX 336-M induce excessive grooming in rats through different mechanisms. Eur.J.Pharmacol. 1983; 88(--):339-346. >>> ACTH(1-24); Saline; CSF/CNS; rat; 2001; 1 week; comparison of agents; peptides.

P0203 Mann,D.R., Jackson,G.G., Blank,M.S. Influence of adrenocorticotropin and adrenalectomy on gonadotropin secretion in immature rats. Neuroendocrinology 1982; 34(--):20-26. >>> ACTH(1-24); ACTH(4-10); ACTH, porcine; Saline; SC; rat; 2001; 6 days; comparison of sc injection vs. infusion; peptides.

P0062 Stewart,J.M., Chipkin,R.E., Channabasavaiah,K., Gay,M.L., Krivoy,W.A. Inhibition of development of tolerance to morphine by a peptide related to ACTH. In 'Neural Peptides and Neuronal Communication,' E.Costa and M.Trabucchi (eds.), Raven Press, New York 1980; (--):305-312. >>> ACTH(1-10)-amide, (D-Phe7)-; Morphine sulfate; SC; mice; 7 days; comparison of injections vs. infusion; separate and simultaneous infusion of agents; peptides.

P0054 Freeman,R.H., Davis,J.O., Fullerton,D. Chronic ACTH administration and the development of hypertension in rats (40799). Proc.Soc.Exp.Biol.Med. 1980; 163(-4-):473-477. >>> ACTH; Saline; SC; rat; 1701; 5-7 days; peptides.

P0037 Cooper,D.O., Stolk,J.M. Differences between inbred rat strains in the alteration of adrenal catecholamine synthesizing enzyme activity after immobilization stress. Neuroscience 1979; 4(--):1163-1172. >>> ACTH; Saline; SC; rat; 5 days; comparison of adrenal denervation vs. hypophysectomy; organ replacement therapy (hypophysectomy); peptides.