References on the Administration of Angiotensin II Using ALZET^® Osmotic Pumps

Q0751 Aljabri,M.B., Songstad,N.T., Lund,T., Serrano,M.C., Andreasen,T.V., Al-Saad,S., Lindal,S., Sitras,V., Acharya,G., Ytrehus,K. Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts. ACTA PHYSIOLOGICA 2011; 201(-4-):445-456. >>> Angiotensin II; Rat (pregnant); rat; ; Controls received mp w/ vehicle; animal info (female Wistar, 10 wks old, 200-250 g); peptides.

Q0786 Barhoumi,T., Kasal,D.A., Li,M.W., Shbat,L., Laurant,P., Neves,M.F., Paradis,P., Schiffrin,E.L. T Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular Injury. Hypertension 2011; 57(-3-):469-U245. >>> Angiotensin II; SC; Mice; 14 days; Controls received PBS injection; animal info (10-12 wks old, C57BL/6, male); peptides; systolic blood pressure measured via tail cuff (MC4000 BP, Hatterars) or telemetry (PA-C10, DSI).

Q0867 Dai,D.F., Johnson,S.C., Villarin,J.J., Chin,M.T., Nieves-Cintron,M., Chen,T., Marcinek,D.J., Dorn,GW II, Kang,Y.J., Prolla,T.A., Santana,L.F., Rabinovitch,P.S. Mitochondrial Oxidative Stress Mediates Angiotensin II-Induced Cardiac Hypertrophy and Galphaq Overexpression-Induced Heart Failure. Circulation Research 2011; 108(-7-):837-U173. >>> Angiotensin II; SC; Mice; 1004; 4 weeks; Animal info (male, C57BL/6NCrl); peptides; blood pressure was measured via telemetry (PA-C10, DSI).

Q0728 Ebrahimian,T., Li,M.W., Lemarie,C.A., Simeone,S.M.C., Pagano,P.J., Gaestel,M., Paradis,P., Wassmann,S., Schiffrin,E.L. Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Angiotensin II-Induced Inflammation and Hypertension Regulation of Oxidative Stress. Hypertension 2011; 57(-2-):245-U220. >>> Angiotensin II; IV; Mice; 14 days; Animal info (14-17 wks old, male, Mk2 KO); peptides; blood pressure measured via radiotelemetry (PAC-10, DSI).

Q0848 Findeisen,H.M., Gizard,F., Zhao,Y., Cohn,D., Heywood,E.B., Jones,K.L., Lovett,D.H., Howatt,D.A., Daugherty,A., Bruemmer,D. Telomerase Deficiency in Bone Marrow-Derived Cells Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-2-):253-U50. >>> Angiotensin II; SC; Mice; 2004; 28 days; Animal info (TERT-/-, wt, ); peptides.

Q0935 Giachini,F.R., Lima,V.V., Carneiro,F.S., Tostes,R.C., Webb,R.C. Decreased cGMP Level Contributes to Increased Contraction in Arteries From Hypertensive Rats Role of Phosphodiesterase 1. Hypertension 2011; 57(-3-):655-663. >>> Angiotensin II; Saline; SC; Rat; 14 days; Controls received mp w/ vehicle; animal info (10 wks old, male Sprague-Dawley, 230-250 g); peptides.

Q0804 Goergen,C.J., Azuma,J., Barr,K.N., Magdefessel,L., Kallop,D.Y., Gogineni,A., Grewall,A., Weimer,R.M., Connolly,A.J., Dalman,R.L., Taylor,C.A., Tsao,P.S., Greve,J.M. Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-2-):270-U102. >>> Angiotensin II; PBS, Dulbecco's; SC; Mice; 2004; 28 days; Controls received mp w/ saline; animal info (apoE -/-, C57BL/6); peptides; post op. care (Buprenorphine); blood pressure was measured via tail cuff at days 0, 3, 7, 14, 21, and 28 (CODA System, Kent Scientific).

Q0674 Grobe,J.L., Buehrer,B.A., Hilzendeger,A.M., Liu,X.B., Davis,D.R., Xu,D., Sigmund,C.D. Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone (DOCA)-Salt in C57 Mice. Hypertension 2011; 57(-3-):600-607. >>> Losartan; angiotensin II; CSF, artificial; CSF/CNS; SC; Mice; ; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 6-8 wks old); peptides.

Q0702 Haque,M.Z., Majid,D.S.A. High Salt Intake Delayed Angiotensin II-Induced Hypertension in Mice With a Genetic Variant of NADPH Oxidase. American Journal of Hypertension 2011; 24(-1-):114-118. >>> Angiotensin II; Salin; acetic acid; SC; Mice; 1002; 2 weeks; Animal info ((8-9 wks old, 24-27 g, gp91PHOX KO, wt); peptides; post op. care (tetracycline in the water); SBP measured via tail-cuff plethysmographs (Visitech Systems); pumps incorrectly listed as 1002D.

Q0894 Hassane,S., Claij,N., Jodar,M., Dedman,A., Lauritzen,I., Duprat,F., Koenderman,J.S., van der Wal,A., Breuning,M.H., de Heer,E., Honore,E., DeRuiter,M.C., Peters,D.J.M. Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension. LABORATORY INVESTIGATION 2011; 91(-1-):24-32. >>> Angiotensin II; PBS; SC; Mice; 2004; 4 weeks; Animal info (Pkd1lox/lox, SM22Cre, 30 wks old); blood pressure measured via tail-cuff method (BP2000, Visitech); peptides.

Q0660 Inscho,E.W., Cook,A.K., Clarke,A., Zhang,S.L., Guan,Z.R. P2X(1) Receptor-Mediated Vasoconstriction of Afferent Arterioles in Angiotensin II-Infused Hypertensive Rats Fed a High-Salt Diet. Hypertension 2011; 57(-4-):780-U247. >>> Angiotensin II; Rat; ; Animal info (male, Sprague-Dawley, 225-250 g); peptides; systolic BP measured every 3-4 days.

Q0638 Kanematsu,Y., Kanematsu,M., Kurihara,C., Tada,Y., Tsou,T.L., van Rooijen,N., Lawton,M.T., Young,W.L., Liang,E.I., Nuki,Y., Hashimoto,T. Critical Roles of Macrophages in the Formation of Intracranial Aneurysm. Stroke 2011; 42(-1-):173-178. >>> Angiotensin II; SC; Mice; 3 weeks; Animal info (8-9 wks old, hypertensive, MCP-1 KO, MMP-12 KO); peptides.

Q0639 Kang,K.T., Sullivan,J.C., Spradley,F.T., d'Uscio,L.V., Katusic,Z.S., Pollock,J.S. Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 2011; 300(-3-):H718-H724. >>> Angiotensin II; SC; Rat; 2 weeks; Animal info (male,Sprague-Dawley, 200-250 g); peptides; blood pressure was measured after day 7 and day 14 via tail-cuff plethsomyography.

Q0726 Katona,M., Denes,J., Skoumal,R., Toth,M., Takats,Z. Intact skin analysis by desorption electrospray ionization mass spectrometry. Analyst 2011; 136(-4-):835-840. >>> Angiotensin II; SC; Rat; ; Animal info (male, Wistar, 8-10 wks old); peptides.

Q0708 Kehat,I., Davis,J., Tiburcy,M., Accornero,F., Saba-El-Leil,M.K., Maillet,M., York,A.J., Lorenz,J.N., Zimmermann,W.H., Meloche,S., Molkentin,J.D. Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth. Circulation Research 2011; 108(-2-):176-U57. >>> Angiotensin II; phenylephrine; Mice; 14 days; Animal info (Erk1-/-); peptides.

Q0692 Leeper,N.J., Raiesdana,A., Kojima,Y., Chun,H.J., Azuma,J., Maegdefessel,L., Kundu,R.K., Quertermous,T., Tsao,P.S., Spin,J.M. MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function. Journal of Cellular Physiology 2011; 226(-4-):1035-1043. >>> Angiotensin II; SC; Mice; 2004; ; animal info (male, ApoE-/-, 10 wks old, 25-30 g); peptides.

Q0869 Lin,C.T., Datta,V., Okwan-Duodu,D., Chen,X., Fuchs,S., Alsabeh,R., Billet,S., Bernstein,K.E., Shen,X.Z. Angiotensin-converting enzyme is required for normal myelopoiesis. FASEB Journal 2011; 25(-4-):1145-1155. >>> Angiotensin II; SC; Mice; ; Animal info (ACE-KO); peptides.

Q0919 Lin,L., Gong,H., Ge,J.Y., Jiang,G.L., Zhou,N., Li,L., Ye,Y., Zhang,G.P., Ge,J.B., Zou,Y.Z. High density lipoprotein downregulates angiotensin II type 1 receptor and inhibits angiotensin II-induced cardiac hypertrophy. Biochemical and Biophysical Research Communications 2011; 404(-1-):28-33. >>> Angiotensin II; SC; Mice; 2 weeks; Animal info (C57BL/6); peptides; blood pressure was measured via a micronanometer catheter in the right common carotid artery (Millar 1.4F, SPR 835, Millar Instruments, Inc. Houston, TX).

Q0802 Nahrendorf,M., Keliher,E., Marinelli,B., Leuschner,F., Robbins,C.S., Gerszten,R.E., Pittet,M.J., Swirski,F.K., Weissleder,R. Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-4-):750-U67. >>> Angiotensin II; SC; Mice; 7, 28 days; nimal info (apoE -/-, 6 mo old, female, C57BL/6J); peptides.

Q0756 Rateri,D.L., Moorleghen,J.J., Balakrishnan,A., Owens,AP III, Howatt,D.A., Subramanian,V., Poduri,A., Charnigo,R., Cassis,L.A., Daugherty,A. Endothelial Cell-Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II-Induced Ascending Aortic Aneurysms in LDL Receptor(-/-) Mice. Circulation Research 2011; 108(-5-):574-U83. >>> Angiotensin II; SC; Mice; 28 days; Controls received mp w/ saline; peptides; animal info (LDL receptor-/-, AT1a receptor-/-, SM22-Cre, Tek-Cre, ROSA26, male); Systolic blood pressure (SBP) measured using Kent Scientific or Visitech tail cuff machine.

Q0649 Skoumal,R., Toth,M., Serpi,R., Rysae,J., Leskinen,H., Ulvila,J., Saiho,T., Aro,J., Ruskoaho,H., Szokodi,I., Kerkelae,R. Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity. Journal of Molecular and Cellular Cardiology 2011; 50(-4-):634-641. >>> Angiotensin II; NaCl; acetic acid; Rat; 1 week; Controls received mp w/ vehicle; peptides; animal info (male, 8 wks old, Sprague-Dawley); telemetry measured mean arterial pressure.

Q0895 Sopel,M.J., Rosin,N.L., Lee,T.D.G., Legare,J.F. Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells. LABORATORY INVESTIGATION 2011; 91(-4-):565-578. >>> Angiotensin II; losartan; SC; Mice; 1, 3, 7 days; Controls received mp w/ saline; animal info (male, C57BL/6, Tie2-GFP); peptides; 7 mm wound clips used.

Q0661 Sparks,M.A., Parsons,K.K., Stegbauer,J., Gurley,S.B., Vivekanandan-Giri,A., Fortner,C.N., Snouwaert,J., Raasch,E.W., Griffiths,R.C., Haystead,T.A.J., Le,T.H., Pennathur,S., Koller,B., Coffman,T.M. Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension. Hypertension 2011; 57(-3-):577-U413. >>> Angiotensin II; SC; Mice; 4 weeks; Animal info (SM22 alpha-Cre+Agtr1a flox/flox, wt, 8-12 wks old); peptides; blood pressure measured via radiotelemetry.

Q0849 Tang,E.H.C., Shvartz,E., Shimizu,K., Rocha,V.Z., Zheng,C., Fukuda,D., Shi,G.P., Sukhova,G., Libby,P. Deletion of EP4 on Bone Marrow-Derived Cells Enhances Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-2-):261-U65. >>> Angiotensin II; SC; Mice; 2004; 28 days; Animal info (C57BL/6 LDLR -/-); peptides; mean blood pressure measured via Visitech tail cuff system; Research Diets D12108.

Q0851 Thatcher,S.E., Zhang,X.A., Howatt,D.A., Lu,H., Gurley,S.B., Daugherty,A., Cassis,L.A. Angiotensin-Converting Enzyme 2 Deficiency in Whole Body or Bone Marrow-Derived Cells Increases Atherosclerosis in Low-Density Lipoprotein Receptor(-/-) Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-4-):758-U87. >>> Losartan; angiotensin II; angiotensin (1-7); SC; Mice; 2001; 1004; 7, 28 days; Controls received mp w/ saline; animal info (Ace2 -/y, 2 mo old); peptides.

Q0893 Wang,Z.C., Tang,L., Zhu,Q., Yi,F., Zhang,F., Li,P.L., Li,N.J. Hypoxia-inducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney International 2011; 79(-3-):300-310. >>> Angiotensin II; IP; Rat; 2002; 2 weeks; Animal info (male, Sprague-Dawley, 250-300 g); peptides.

Q0711 Yatabe,J., Yoneda,M., Yatabe,M.S., Watanabe,T., Felder,R.A., Jose,P.A., Sanada,H. Angiotensin III Stimulates Aldosterone Secretion from Adrenal Gland Partially via Angiotensin II Type 2 Receptor But Not Angiotensin II Type 1 Receptor. Endocrinology 2011; 152(-4-):1582-1588. >>> Angiotensin II; angiotensin III; angiotensin IV; angiotensin (1-7); PD123319; PBS; SC; Rat; 2002; 5 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, 8 wks old); peptides.

Q0897 Yoshida,Y., Fukuda,N., Maeshima,A., Yamamoto,C., Matsumoto,T., Ueno,T., Nojima,Y., Matsumoto,K., Soma,M. Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats. Journal of Hypertension 2011; 29(-1-):91-101. >>> Angiotensin II; uridine, bromodeoxy; SC; IP; Rat; 1, 2 weeks; Animal info (Wistar Kyoto); peptides; systolic blood pressure was measured by tail-cuff (BO-98A; Softron Co).

Q0803 Zack,M., Boyanovsky,B.B., Shridas,P., Bailey,W., Forrest,K., Howatt,D.A., Gelb,M.H., de Beer,F.C., Daugherty,A., Webb,N.R. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis 2011; 214(-1-):58-64. >>> Angiotensin II; SC; Mice; 2004; 10, 28 days; Controls received mp w/ saline; animal info (apoE -/-); peptides.

Q0822 Zhong,J.C., Guo,D.N., Chen,C.B., Wang,W., Schuster,M., Loibner,H., Penninger,J.M., Scholey,J.W., Kassiri,Z., Oudit,G.Y. Prevention of Angiotensin II-Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2. Hypertension 2011; 57(-2-):314-U338. >>> Angiotensin II; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ saline; animal info (ACE2 KO, wt); peptides.

Q0679 Zhu,D.L., Shi,J.P., Zhang,Y.D., Wang,B.R., Liu,W., Chen,Z.C., Tong,Q.A. Central Angiotensin II Stimulation Promotes beta Amyloid Production in Sprague Dawley Rats. PLoS One 2011; 6(-1-):U121-U129. >>> Angiotensin II; Saline, sterile; CSF/CNS; Rat; 2004; 1 week; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 280-310 g); peptides; ALZET brain infusion kit used.

Q0001 Ago,T., Kuroda,J., Pain,J., Fu,C.X., Li,H., Sadoshima,J. Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes. Circulation Research 2010; 106(-7-):1253-U183. >>> Angiotensin II; phenylephrine; Mice (transgenic); 14 days; Controls received mp w/ vehicle; peptides.

Q0214 Ardanaz,N., Yang,X.P., Cifuentes,M.E., Haurani,M.J., Jackson,K.W., Liao,T.D., Carretero,O.A., Pagano,P.J. Lack of Glutathione Peroxidase 1 Accelerates Cardiac-Specific Hypertrophy and Dysfunction in Angiotensin II Hypertension. Hypertension 2010; 55(-1-):116-U208. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 7 days; Controls received mp w/ vehicle; animal info (18-20 wks old, male, Gpx1 -/-).

Q0684 Brands,M.W., Banes-Berceli,A.K.L., Inscho,E.W., Al-Azawi,H., Allen,A.J., Labazi,H. Interleukin 6 Knockout Prevents Angiotensin II Hypertension Role of Renal Vasoconstriction and Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Activation. Hypertension 2010; 56(-5-):879-884. >>> Angiotensin II; Mice; 1007D; 7 days; Animal info (12-14-wks old, 23-28 g, male, IL-6 KO); blood pressure measured using biotelemetry transmitter devices (Data Sciences, PA-C10).

Q0740 Carlstroem,M., Lai,E.Y., Ma,Z.F., Steege,A., Patzak,A., Eriksson,U.J., Lundberg,J.O., Wilcox,C.S., Persson,A.E.G. Superoxide Dismutase 1 Limits Renal Microvascular Remodeling and Attenuates Arteriole and Blood Pressure Responses to Angiotensin II via Modulation of Nitric Oxide Bioavailability. Hypertension 2010; 56(-5-):907-U373. >>> Angiotensin II; SC; Mice (transgenic); 14 days; Animal info (wt, SOD1-KO); peptides; blood pressure measured via telemetra (PA-C10, DSI).

Q0110 Chan,E.C., Dusting,G.J., Guo,N., Peshavariya,H.M., Taylor,C.J., Dilley,R., Narumiya,S., Jiang,F. Prostacyclin receptor suppresses cardiac fibrosis: Role of CREB phosphorylation. Journal of Molecular and Cellular Cardiology 2010; 49(-2-):176-185. >>> Angiotensin II; Saline; SC; Mice; 2 weeks; Controls received mp w/ vehicle; peptides; no stress (pg. 178); animal info (C57BL/6, ApoE-/-, IP-/-, IP+/+, 16-18 weeks old); functionality of mp verified by systolic blood pressure; dose-response (Table 1).

Q0315 Chen,C.C.A., Pedraza,P.L., Hao,S.J., Stier,C.T., Ferreri,N.R. TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusion. American Journal of Physiology-Renal Physiology 2010; 299(-5-):F1141-F1150. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 1002; 7 days; Controls received mp w/ vehicle; animal info (7-10 wks old, male, C57BL/6J, wt, TNFR1 -/-); peptides; telemetry probes (TA11PA-C10) used.

P9995 Chrissobolis,S., Faraci,F.M. Sex Differences in Protection Against Angiotensin II-Induced Endothelial Dysfunction by Manganese Superoxide Dismutase in the Cerebral Circulation. Hypertension 2010; 55(-4-):905-U164. >>> Angiotensin II; Saline, isotonic; SC; Mice; 1002; 7 days; Controls received mp w/ vehicle; peptides; animal info (MnSOD +/+, +/-, male); cardiovascular.

Q0216 Crowley,S.D., Song,Y.S., Sprung,G., Griffiths,R., Sparks,M., Yan,M., Burchette,J.L., Howell,D.N., Lin,E.E., Okeiyi,B., Stegbauer,J., Yang,Y.Q., Tharaux,P.L., Ruiz,P. A Role for Angiotensin II Type 1 Receptors on Bone Marrow-Derived Cells in the Pathogenesis of Angiotensin II-Dependent Hypertension. Hypertension 2010; 55(-1-):99-U180. >>> Angiotensin II; SC; Mice; 2004; 28 days; Controls received mp w/ saline; animal info (2-4 months old, male, Agtr1a -/-); peptides.

Q0316 Dai,W.J., He,W.Q., Shang,G.D., Jiang,J.D., Wang,Y.G., Kong,W.J. Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-5-):H1468-H1475. >>> Angiotensin II; PBS; acetic acid; SC; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 20 g); peptides.

P9902 Dai,W.J., Chen,H.Y., Jiang,J.D., Kong,W.J., Wang,Y.G. Silencing MR-1 attenuates inflammatory damage in mice heart induced by AngII. Biochemical and Biophysical Research Communications 2010; 391(-3-):1573-1578. >>> Angiotensin II; PBS; acetic acid; SC; Mice; 2002; 2 weeks; Controls received mp w/vehicle; peptides; animal info (8 wks old, male, C57BL/6J).

P9893 Danpinid,A., Luo,J.W., Vappou,J., Terdtoon,P., Konofagou,E.E. In vivo characterization of the aortic wall stress-strain relationship. ULTRASONICS 2010; 50(-7-):654-665. >>> Angiotensin II; SC; Mice; 2004; ; Peptides; animal info (C57BL/6, male, 7-10 mo. old).

Q0509 Daugherty,A., Rateri,D.L., Charos,I.F., Owens,AP III, Howatt,D.A., Cassis,L.A. Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice. Clinical Science 2010; 118(-11-12-):681-689. >>> Angiotensin II; SC; Mice; 2004; 28 days; Controls received mp w/ saline; animal info (ApoE -/- x CCR2 +/-).

Q0352 Diez,R.R., Rodrigues-Diez,R., Lavoz,C., Rayego-Mateos,S., Civantos,E., Rodriguez-Vita,J., Mezzano,S., Ortiz,A., Egido,J., Ruiz-Ortega,M. Statins Inhibit Angiotensin II/Smad Pathway and Related Vascular Fibrosis, by a TGF-beta-Independent Process. PLoS One 2010; 5(-11-):U287-U297. >>> Angiotensin II; SC; Rat; 3 days; Animal info (Wistar, male, 3 months old); peptides; blood pressure was measured by tail-cuff pletysmography.

Q0229 Eagleton,M.J., Xu,J., Liao,M.F., Parine,B., Chisolm,G.M., Graham,L.M. Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formation. JOURNAL OF VASCULAR SURGERY 2010; 51(-4-):951-961. >>> Angiotensin II; Saline; SC; Mice; 2004; 3, 5, 7, 10, 14, 28 days; Peptides; animal info (ApoE -/-, null, Stat 1 double KO).

P9998 Facemire,C.S., Griffiths,R., Audoly,L.P., Koller,B.H., Coffman,T.M. The Impact of Microsomal Prostaglandin E Synthase 1 on Blood Pressure Is Determined by Genetic Background. Hypertension 2010; 55(-2-):531-538. >>> Angiotensin II; SC; Mice; 2004; 3 weeks; Peptides; cardiovascular; animal info (DBA/1 mPEGS1 -/-).

Q0011 Feng,Y.M., Xia,H.J., Cai,Y.H., Halabi,C.M., Becker,L.K., Santos,R.A.S., Speth,R.C., Sigmund,C.D., Lazartigues,E. Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension. Circulation Research 2010; 106(-2-):373-U91. >>> Angiotensin II; angiotensin (1-7), d-ala7-; SC; Mice (transgenic); 14 days; Controls received mp w/saline; peptides; cardiovascular; animal info (male, C57BL/6JxSJL/J, SAtg, 8-10 weeks old).

Q0245 Gariepy,H.D., Carayon,P., Ferrari,B., Couture,R. Contribution of the central dopaminergic system in the anti-hypertensive effect of kinin B1 receptor antagonists in two rat models of hypertension. Neuropeptides 2010; 44(-2-):191-198. >>> Angiotensin II; SC; Rat; 2002; 14 days; Controls received mp w/ or sham operation; peptides; animal info (male, SHR, 15-16 wks old, WKY, 200-225 g).

Q0752 Golledge,J., Cullen,B., Moran,C., Rush,C. Efficacy of Simvastatin in Reducing Aortic Dilatation in Mouse Models of Abdominal Aortic Aneurysm. Cardiovascular Drugs and Therapy 2010; 24(-5-6-):373-378. >>> Angiotensin II; Saline, sterile; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, ApoE -/-, 13 wks old); peptides.

Q0215 Gomes,E.R.M., Lara,A.A., Almeida,P.W.M., Guimaraes,D., Resende,R.R., Campagnole-Santos,M.J., Bader,M., Santos,R.A.S., Guatimosim,S. Angiotensin-(1-7) Prevents Cardiomyocyte Pathological Remodeling Through a Nitric Oxide/Guanosine 3'5'-Cyclic Monophosphate-Dependent Pathway. Hypertension 2010; 55(-1-):153-U268. >>> Angiotensin II; NaCl; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (Sprague Dawley, 3-4 wks old, transgenic).

Q0546 Guilluy,C., Bregeon,J., Toumaniantz,G., Rolli-Derkinderen,M., Retailleau,K., Loufrani,L., Henrion,D., Scalbert,E., Bril,A., Torres,R.M., Offermanns,S., Pacaud,P., Loirand,G. The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nature Medicine 2010; 16(-2-):183-U89. >>> Angiotensin II; Saline; SC; Mice; 2004; 21 days; Controls received mp w/ vehicle; animal info (SMArhgef1-KO); peptides.

Q0320 Huang,B.S., Ahmadi,S., Ahmad,M., White,R.A., Leenen,F.H.H. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-2-):U207-U215. >>> Angiotensin II; FAD-286; aldosterone, d-; Saline; CSF, artificial; ethanol; SC; CSF/CNS; Rat; 2001D; 2001; 2002; 2004; 2 weeks; 1, 4 days; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250 g); peptides; dose-response; enzyme inhibitor (aldosterone synthase); multiple pumps per animal (2); telemetry probe (model TA11PA-C40, DSI) used to measure BP and HR; 1% ethanol used with aldosterone.

Q0122 Huang,X.R., Chung,A.C.K., Yang,F.Y., Yue,W.S., Deng,C.X., Lau,C.P., Tse,H.F., Lan,H.Y. Smad3 Mediates Cardiac Inflammation and Fibrosis in Angiotensin II-Induced Hypertensive Cardiac Remodeling. Hypertension 2010; 55(-5-):1165-U153. >>> Angiotensin II; Saline; SC; Mice; 14 days; Controls received mp w/ vehicle; peptides; cardiovascular; animal info (C57BL/6 wt, Smad3 KO); functionality of mp verified by systolic blood pressure.

Q0125 Ji,H., Zheng,W., Wu,X., Liu,J., Ecelbarger,C.M., Watkins,R., Arnold,A.P., Sandberg,K. Sex Chromosome Effects Unmasked in Angiotensin II-Induced Hypertension. Hypertension 2010; 55(-5-):1275-1282. >>> Angiotensin II; Saline; SC; Mice; 1002; 2 weeks; Peptides; cardiovascular; animal info (male, female, MF1: wt, XY-/-, XXSry, XY-/-Sry, FCG, 6-9 months old); dose-response (fig 2 and 3); replacement therapy (gonadectomy);.

Q0480 Jiang,S.Y., Xu,M., Ma,X.W., Xiao,H., Zhang,Y.Y. A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by l-thyroxine and angiotensin II. Clinical and Experimental Pharmacology and Physiology 2010; 37(-9-):919-925. >>> Angiotensin II; Saline; SC; Mice; 2002; 14 days; Controls received mp w/vehicle; animal info (AMPK-alpha-2 KO, wt, 12 wks old, 18-21 g); peptides.

Q0149 Kane,M.O., Etienne-Selloum,N., Madeira,S.V.F., Sarr,M., Walter,A., Dal-Ros,S., Schott,C., Chataigneau,T., Schini-Kerth,V.B. Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2010; 459(-5-):671-679. >>> Angiotensin II; Sodium chloride; SC; Rat; 2004; 14 days; Controls received sham operation; peptides; animal info (male, Wistar).

P9980 Kanematsu,Y., Kanematsu,M., Kurihara,C., Tsou,T.L., Nuki,Y., Liang,E.I., Makino,H., Hashimoto,T. Pharmacologically Induced Thoracic and Abdominal Aortic Aneurysms in Mice. Hypertension 2010; 55(-5-):1267-1274. >>> BAPN; angiotensin II; SC; Mice; 2 weeks; Peptides; enzyme inhibitor (lysyl oxidase); animal info (C57BL/6J, 9 wks old).

Q0898 Kasselman,L.J., Rutkove,S.B. APPLICATION OF ANGIOTENSIN II TO HEALTHY RAT SCIATIC NERVE CAN PRODUCE NEUROPATHY WITHOUT ASSOCIATED VASCULOPATHY. Muscle&Nerve 2010; 42(-6-):959-965. >>> Angiotensin II; CSF/CNS (sciatic nerve); Rat; 2004; 12 weeks; Controls received mp w/ PBS; animal info (male, Wistar, 250-300 g); peptides; long-term study; good methods, pg 960; no stress (see pg. 961) "All animals from both groups survived the surgery without complications"; pump connected to silicone tube that was connected to a piece of Gelfoam; Fig. 1, schematic of pump, tube, and gelfoam. pg 960.

Q0406 Kinoshita,H., Kuwahara,K., Nishida,M., Jian,Z., Rong,X.L., Kiyonaka,S., Kuwabara,Y., Kurose,H., Inoue,R., Mori,Y., Li,Y.H., Nakagawa,Y., Usami,S., Fujiwara,M., Yamada,Y., Minami,T., Ueshima,K., Nakao,K. Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart. Circulation Research 2010; 106(-12-):1849-U153. >>> Angiotensin II; Acetic acid; SC; Mice; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (12 wks old, GC-A KO); peptides; bp measured one week after implant.

Q0579 Klaiber,M., Kruse,M., Voelker,K., Schroeter,J., Feil,R., Freichel,M., Gerling,A., Feil,S., Dietrich,A., Londono,J.E.C., Baba,H.A., Abramowitz,J., Birnbaumer,L., Penninger,J.M., Pongs,O., Kuhn,M. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Research In Cardiology 2010; 105(-5-):583-595. >>> Angiotensin II; isoproterenol; SC; Mice; 2002; 7 days; Animal info (CM GC-A KO, male, female, 4-6 wks old); peptides; arterial blood pressure measured by tail cuff.

Q0947 Kuwahara,K., Kinoshita,H., Kuwabara,Y., Nakagawa,Y., Usami,S., Minami,T., Yamada,Y., Fujiwara,M., Nakao,K. Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression. MOLECULAR AND CELLULAR BIOLOGY 2010; 30(-17-):4134-4148. >>> Angiotensin II; Acetic acid; SC; Mice; 2002; 14 days; Animal info (10 wks old, wt); blood pressure was measured via tail cuff (Muramachi); peptides.

Q0327 LeBlanc,R.M., Navar,L.G., Botros,F.T. Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension. American Journal of the Medical Sciences 2010; 340(-2-):144-146. >>> Angiotensin II; Acetic acid; SC; Rat; ; Animal info (male, Sprague-Dawley, 200-250 g); peptides; 200 ul sized pump used; systolic arterial blood was measured in conscious rats using tail cuff (Fig 1a).

P9918 Li,H., Li,W.W., Gupta,A.K., Mohler,P.J., Anderson,M.E., Grumbach,I.M. Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-2-):H688-H698. >>> Angiotensin II; Mice; 10 days; Peptides; animal info (8 wks old, C57BL/6).

Q0219 Li,P., Shibata,R., Unno,K., Shimano,M., Furukawa,M., Ohashi,T., Cheng,X.W., Nagata,K., Ouchi,N., Murohara,T. Evidence for the Importance of Adiponectin in the Cardioprotective Effects of Pioglitazone. Hypertension 2010; 55(-1-):69-U111. >>> Angiotensin II; SC; Mice; 14 days; Peptides; animal info (male, C57BL/6J, 8-10 wks old, APN-KO).

Q0946 Liang,L., Tam,C.W., Pozsgai,G., Siow,R., Clark,N., Keeble,J., Husmann,K., Born,W., Fischer,J.A., Poston,R., Shah,S., Brain,S.D. Protection of Angiotensin II-Induced Vascular Hypertrophy in Vascular Smooth Muscle-Targeted Receptor Activity-Modifying Protein 2 Transgeic Mice. Hypertension 2010; 54(--):1254-1261. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 1002; ; Controls received mp w/ vehicle; animal info ((25-35 g, 12 - 16 wks old, RAMP2 TG, wt); peptides.

Q0171 Loria,A.S., Pollock,D.M., Pollock,J.S. Early Life Stress Sensitizes Rats to Angiotensin II-Induced Hypertension and Vascular Inflammation in Adult Life. Hypertension 2010; 55(-2-):494-U416. >>> Angiotensin II; SC; Rat; 2 weeks; Controls received mp w/ vehicle; peptides; cardiovascular; animal info (Wistar-Kyoto, 9-10 weeks old); behavioral testing (locomotor activity).

P9993 Madhur,M.S., Lob,H.E., McCann,L.A., Iwakura,Y., Blinder,Y., Guzik,T.J., Harrison,D.G. Interleukin 17 Promotes Angiotensin II-Induced Hypertension and Vascular Dysfunction. Hypertension 2010; 55(-2-):500-U435. >>> Angiotensin II; Sodium chloride; acetic acid; Mice; 2002; 2004; 2, 4 weeks; Controls received mp w/ vehicle; animal info (IL-17, -/-, 10-12 wks old).

Q0173 Maillet,M., Davis,J., uger-Messier,M., York,A., Osinska,H., Piquereau,J., Lorenz,J.N., Robbins,J., Ventura-Clapier,R., Molkentin,J.D. Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function. Journal of Biological Chemistry 2010; 285(-9-):6716-6724. >>> Angiotensin II; phenylephrine; isoprenaline; Saline, physiological; acetic acid; PBS; SC; Mice; 2 weeks; Controls received mp w/ vehicle; peptides; cardiovascular; animal info (C57BL/6, wt, CnB1fl/fl-aMHC-Cre, 2 months old); behavioral response (forced swimming).

P9978 Matsusaka,T., Asano,T., Niimura,F., Kinomura,M., Shimizu,A., Shintani,A., Pastan,I., Fogo,A.B., Ichikawa,I. Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent. Hypertension 2010; 55(-4-):967-U288. >>> Angiotensin II; SC; Mice; 2002; 14 days; Peptides; animal info (female, 13 months old).

Q0023 McCalmon,S.A., Desjardins,D.M., Ahmad,S., Davidoff,K.S., Snyder,C.M., Sato,K., Ohashi,K., Kielbasa,O.M., Mathew,M., Ewen,E.P., Walsh,K., Gavras,H., Naya,F.J. Modulation of Angiotensin II-Mediated Cardiac Remodeling by the MEF2A Target Gene Xirp2. Circulation Research 2010; 106(-5-):952-U261. >>> Angiotensin II; SC; Mice; 2004; 14 days; Controls received empty minipump; peptides; cardiovascular; animal info (wt, Xirp2 loxP-neo targeted).

Q0351 Mokni,W., Keravis,T., Etienne-Selloum,N., Walter,A., Kane,M.O., Schini-Kerth,V.B., Lugnier,C. Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II. PLoS One 2010; 5(-11-):U195-U209. >>> Angiotensin II; Saline; SC; Rat; 2004; 14 days; Controls received sham operation; animal info (male, Wistar, 10 wks old); peptides; systolic blood pressure and heart rate were measured using a tail-cuff plethysmograph connected to a computerized system (LE 5002, BIOSEB) in conscious rats before the infusion (D0) and at the end of treatment (D14); (see fig 1a, pg e14227).

Q0487 Nakayama,H., Bodi,I., Maillet,M., DeSantiago,J., Domeier,T.L., Mikoshiba,K., Lorenz,J.N., Blatter,L.A., Bers,D.M., Molkentin,J.D. The IP3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli. Circulation Research 2010; 107(-5-):659-U222. >>> Isoproterenol; angiotensin II; Mice; 2002; 2 weeks; Controls received mp w/PBS; animal info (DTG, 2 mo old, CnA beta Tg); peptides.

Q0319 Nath,K.A., Hernandez,M.C., Croatt,A.J., Katusic,Z.S., Juncos,L.A. Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 299(-5-):R1183-R1191. >>> Angiotensin II; Saline; IV; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley); peptides; mean arterial pressure measured.

Q0025 Olzinski,A.R., Turner,G.H., Bernard,R.E., Karr,H., Cornejo,C.A., Aravindhan,K., Hoang,B., Ringenberg,M.A., Qin,P., Goodman,K.B., Willette,R.N., Macphee,C.H., Jucker,B.M., Sehon,C.A., Gough,P.J. Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E-/- Mouse: Magnetic Resonance Imaging Assessment. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010; 30(-2-):253-U240. >>> Angiotensin II; SC; Mice; 2004; 5 weeks; Peptides; cardiovascular; animal info (huCCR2ki/ApoE-/-, 22-24 weeks old).

Q0234 Osborn,J.W., Fink,G.D. Region-specific changes in sympathetic nerve activity in angiotensin II-salt hypertension in the rat. Experimental Physiology 2010; 95(-1-):61-68. >>> Angiotensin II; SC; Rat; 14 days; Peptides; animal info (male, Sprague Dawley).

Q0026 Owens,AP III, Subramanian,V., Moorleghen,J.J., Guo,Z.H., McNamara,C.A., Cassis,L.A., Daugherty,A. Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3. Circulation Research 2010; 106(-3-):611-U108. >>> Angiotensin II; norepinephrine; losartan; Saline; Mice; 4 weeks; 28 days; Controls received mp w/vehicle; peptides; cardiovascular; animal info (male, C57BL/6, AT1aR -/-, p47phox -/-, Id3 -/-); functionality of mp verified by systolic blood pressure.

Q0416 Pedram,A., Razandi,M., O'Mahony,F., Lubahn,D., Levin,E.R. Estrogen Receptor-beta Prevents Cardiac Fibrosis. MOLECULAR ENDOCRINOLOGY 2010; 24(-11-):2152-2165. >>> Angiotensin II; Saline; SC; Mice; 21 days; Controls received mp w/ vehicle; animal info (Ovariectomized female wild-type (WT), ER-beta KO); peptides.

Q0077 Pojoga,L.H., Romero,J.R., Yao,T.M., Loutraris,P., Ricchiuti,V., Coutinho,P., Guo,C., Lapointe,N., Stone,J.R., Adler,G.K., Williams,G.H. Caveolin-1 Ablation Reduces the Adverse Cardiovascular Effects of N-omega-Nitro-L-Arginine Methyl Ester and Angiotensin II. Endocrinology 2010; 151(-3-):1236-1246. >>> Angiotensin II; SC; Mice; 1007D; 5 days; Peptides; animal info (cav-1 KO, wt, 12 wks old).

P9906 Police,S.B., Putnam,K., Thatcher,S., Batifoulier-Yiannikouris,F., Daugherty,A., Cassis,L.A. Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-6-):H1932-H1938. >>> Angiotensin II; SC; Mice; 2004; 12 weeks; Controls received mp w/vehicle, or saline; pumps replaced every 4 weeks; peptides; animal info (male, C57BL/6, 8 wks old); Research Diets D12492.

Q0925 Rudolph,V., Andrie,R.P., Rudolph,T.K., Friedrichs,K, Kline,A, Hirsch-Hoffmann,B, Schwoerer,A.P., Lau,D, Fu,X., Klingel,K., Sydow,K., Didie,M., Seniuk,A  Nature Medicine 2010; 16(-4-):470-474. >>> Angiotensin II; myeloperoxidase; Saline; SC; IV (jugular); Mice; 7, 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6J, Mpo -/-, 12-15 wks old); peptides.

Q0184 Sabharwal,R., Zhang,Z.M., Lu,Y.J., Abboud,F.M., Russo,A.F., Chapleau,M.W. Receptor Activity-Modifying Protein 1 Increases Baroreflex Sensitivity and Attenuates Angiotensin-Induced Hypertension. Hypertension 2010; 55(-3-):627-U17. >>> Angiotensin II; SC; Mice (transgenic); 1002; 14 days; Control wt (non Tg) mice recieved ang II (not vehicle); peptides; cardiovascular; animal info (male, wt, hRAMP1 Tg, 10-20 weeks old).

Q0317 Saeed,A., Dibona,G.F., Marcussen,N., Guron,G. High-NaCl intake impairs dynamic autoregulation of renal blood flow in ANG II-infused rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 299(-5-):R1142-R1149. >>> Angiotensin II; Saline, isotonic; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, ~300 g); peptides; arterial pressure catheter was inserted via the femoral artery and was connected to a pressure transducer (Smiths Medical, Kirchseeon, Germany), to measure MAP and heart rate using MP 150; Biopac Systems, Santa Barbara, CA..

Q0069 Schellings,M.W.M., Vanhoutte,D., van Almen,G.C., Swinnen,M., Leenders,J.J.G., Kubben,N., van Leeuwen,R.E.W., Hofstra,L., Heymans,S., Pinto,Y.M. Syndecan-1 Amplifies Angiotensin II-Induced Cardiac Fibrosis. Hypertension 2010; 55(-2-):249-U87. >>> Angiotensin II; Mice; 2ML4; 14 days; Peptides; animal info (14- 20 wks old, Balb/c, inbred, Cynd-1 null, wt).

Q0068 Schuhmacher,S., Wenzel,P., Schulz,E., Oelze,M., Mang,C., Kamuf,J., Gori,T., Jansen,T., Knorr,M., Karbach,S., Hortmann,M., Maethner,F., Bhatnagar,A., Foerstermann,U., Li,H., Muenzel,T., Daiber,A. Pentaerythritol Tetranitrate Improves Angiotensin II-Induced Vascular Dysfunction via Induction of Heme Oxygenase-1. Hypertension 2010; 55(-4-):897-U153. >>> Angiotensin II; PETN; ISMN; DMSO; SC; Rat; mice; 7 days; Controls received mp w/ vehicle; multiple pumps per animal; animal info (male, Wistar, 7 wks old, 250 g., HO-1, +/+ or -/-, 3-4 months old); PETN is pentaerythritol tetranitrate; ISMN is isosorbide-5 mononitrate.

Q0741 Senchenkova,E.Y., Russell,J., meida-Paula,L.D., Harding,J.W., Granger,D.N. Angiotensin II-Mediated Microvascular Thrombosis. Hypertension 2010; 56(-6-):1089-U174. >>> Angiotensin II; SC; Mice; 14 days; Animal info (AT1r -/-, wt); peptides; post op. care (topical antibotic, neosporin); blood pressure monitored via tail cuff (Hatteras Instruments).

Q0066 Shi,P., ez-Freire,C., Jun,J.Y., Qi,Y.F., Katovich,M.J., Li,Q.H., Sriramula,S., Francis,J., Sumners,C., Raizada,M.K. Brain Microglial Cytokines in Neurogenic Hypertension. Hypertension 2010; 56(-2-):297-303. >>> Minocycline; angiotensin II; SC; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ saline; ALZET brain infusion kit used; multiple pumps per animal (2); post op. care (buprenorphine); animal info (male, Sprague Dawley, 6 wks old).

P9903 Talati,G., Ohta,A., Rai,T., Sohara,E., Naito,S., Vandewalle,A., Sasaki,S., Uchida,S. Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochemical and Biophysical Research Communications 2010; 393(-4-):844-848. >>> Angiotensin II; valsartan; Saline; BSA; Mice; 1002; 5, 10 days; Peptides; animal info (male, 12 wks old, C57BL6/J).

Q0189 Tozakidou,M., Goltz,D., Hagenstroem,T., Budack,M.K., Vitzthum,H., Szlachta,K., Baering,R., Ehmke,H. Molecular and functional remodeling of Ito by angiotensin II in the mouse left ventricle. Journal of Molecular and Cellular Cardiology 2010; 48(-1-):140-151. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 1003D; 2002; 14 days; 24 hours; Controls received mp w/ vehicle; peptides; cardiovascular; animal info (male, C57BL/6, 8-12 weeks old).

Q0304 Uchida,H.A., Kristo,F., Rateri,D.L., Lu,H., Charnigo,R., Cassis,L.A., Daugherty,A. Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice. Atherosclerosis 2010; 211(-2-):399-403. >>> Angiotensin II; SC; Mice; 2004; 28 days; Controls received mp w/ saline; animal info (Rag-1 +/- and -/- x apoE -/-, 8-10 wks old, male, female); peptides; "SBP was measured on conscious mice for 5 consecutive days prior to and the last week during AngII infusion using a Visitech tail cuff system" pg 400.

Q0359 Vailati,M.D.F., Rocha,N.S., Matsubara,L.S., Padovani,C.R., Schwartz,D.S., Matsubara,B.B. AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats. PESQUISA VETERINARIA BRASILEIRA 2010; 30(-7-):605-611. >>> Angiotensin II; SC; Rat; 2002; 72 hours; Animal info (8-wks old, male, Wistar, 250 g); peptides; tail cuff blood pressure and heart rate (HR) were monitored one day before the beginning of the treatment and immediately before sacrifice.

Q0481 van Berlo,J.H., Elrod,J.W., van den Hoogenhof,M.M.G., York,A.J., Aronow,B.J., Duncan,S.A., Molkentin,J.D. The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy. Circulation Research 2010; 107(-8-):1032-U178. >>> Angiotensin II; phenylephrine; Mice; 2 weeks; Animal info (young adult, Gata6fl/flMHC-cre Tg); peptides.

Q0168 Vengas-Pont,M., Sartori-Valinotti,J.C., Glover,P.H., Reckelhoff,J.F. Sexual Dimorphism in the Blood Pressure Response to Angiotensin II in Mice After Angiotensin-converting Enzyme Blockade. American Journal of Hypertension 2010; 23(-1-):92-96. >>> Angiotensin II; Saline; SC; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (20 wks old, male, female, C57BL/6J).

P9994 Wakui,H., Tamura,K., Tanaka,Y., Matsuda,M., Bai,Y., Dejima,T., Masuda,S., Shigenaga,A., Maeda,A., Mogi,M., Ichihara,N., Kobayashi,Y., Hirawa,N., Ishigami,T., Toya,Y., Yabana,M., Horiuchi,M., Minamisawa,S., Umemura,S. Cardiac-Specific Activation of Angiotensin II Type 1 Receptor-Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II-Infused Mice. Hypertension 2010; 55(-5-):1157-U138. >>> Angiotensin II; Mice; 1003D; 2001D; 2001; 2002; 3, 14 days; 15, 30, 60 minutes; Controls received mp w/ vehicle; animal info (male, TG A-Trap +/+); peptides.

Q0312 Wakui,H., Tamura,K., Matsuda,M., Bai,Y.Z., Dejima,T., Shigenaga,A., Masuda,S., Azuma,K., Maeda,A., Hirose,T., Ishigami,T., Toya,Y., Yabana,M., Minamisawa,S., Umemura,S. Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice. American Journal of Physiology-Renal Physiology 2010; 299(-5-):F991-F1003. >>> Angiotensin II; SC; 14 days; Controls received mp w/ vehicle; animal info (Adult, male, C57BL/6, 10-12 wks old); peptides; systolic blood pressure and heart rate were measured by the tail-cuff method (BP monitor MK-2000); SBP measured day 7 and 14, see Fig. 1.

Q0193 Wang,M.Y., Zhang,J., Walker,S.J., Dworakowski,R., Lakatta,E.G., Shah,A.M. Involvement of NADPH oxidase in age-associated cardiac remodeling. Journal of Molecular and Cellular Cardiology 2010; 48(-4-):765-772. >>> Angiotensin II; SC; Rat; 28 days; Animal info (male, Fisher 344 x BrownNorway; 8 months old); cardiovascular; peptides.

Q0194 Wang,Y., it-Oufella,H., Herbin,O., Bonnin,P., Ramkhelawon,B., Taleb,S., Huang,J., Offenstadt,G., Combadiere,C., Renia,L., Johnson,J.L., Tharaux,P.L., Tedgui,A., Mallat,Z. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. Journal of Clinical Investigation 2010; 120(-2-):422-432. >>> Angiotensin II; SC; Mice; 18-28 days; Animal info (male, C57BL/6J, wt, apoE-/-, Il4-/-, Il6-/-, Rag2-/-, 8-12 weeks old) peptides; cardiovascular.

Q0088 Wenzel,K., Wallukat,G., Qadri,F., Hubner,N., Schulz,H., Hummel,O., Herse,F., Heuser,A., Fischer,R., Heidecke,H., Luft,F.C., Muller,D.N., Dietz,R., Dechend,R. alpha1A-Adrenergic Receptor-Directed Autoimmunity Induces Left Ventricular Damage and Diastolic Dysfunction in Rats. PLoS One 2010; 5(-2-):U271-U278. >>> Angiotensin II; Rat; 14 days; Animal info (male, Lewis, 8 weeks old).

P9953 Wu,X., Eder,P., Chang,B.J., Molkentin,J.D. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-15-):7000-7005. >>> Angiotensin II; phenylephrine; PBS; SC; Mice; 1002; ; Controls received mp w/ vehicle; animal info (Nfat-luciferase, heart specific Trpc3Tg).

Q0218 Wysocki,J., Ye,M.H., Rodriguez,E., Gonzalez-Pacheco,F.R., Barrios,C., Evora,K., Schuster,M., Loibner,H., Brosnihan,K.B., Ferrario,C.M., Penninger,J.M., Batlle,D. Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2 Prevention of Angiotensin II-Dependent Hypertension. Hypertension 2010; 55(-1-):90-U160. >>> Angiotensin-converting enzyme 2, recomb. human; angiotensin II; SC; Mice; 1003D; 3 days; Controls received sham operation; dose-response; peptides; animal info (male, C57BL/6J, 10 wks old, ACE2 KO); one group received mp with rACE2 and angiotensin II.

P9996 Yagi,S., Akaike,M., Aihara,K., Ishikawa,K., Iwase,T., Ikeda,Y., Soeki,T., Yoshida,S., Sumitomo-Ueda,Y., Matsumoto,T., Sata,M. Endothelial Nitric Oxide Synthase-Independent Protective Action of Statin Against Angiotensin II-Induced Atrial Remodeling via Reduced Oxidant Injury. Hypertension 2010; 55(-4-):918-U194. >>> Angiotensin II; SC; Mice; 2 weeks; Controls received sham operation; animal info (10 wks old, male, eNOS -/-).

P9911 Yamanouchi,D., Morgan,S., Kato,K., Lengfeld,J., Zhang,F., Liu,B. Effects of Caspase Inhibitor on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010; 30(-4-):702-U134. >>> Angiotensin II; SC; Mice; 2004; 4 weeks; Controls received mp w/ saline; peptides; animal info (male, 24 wks old, Apoe -/-).

P9924 Yoshida,T., Semprun-Prieto,L., Sukhanov,S., Delafontaine,P. IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-5-):H1565-H1570. >>> Angiotensin II; Mice; 1007D; 7 days; Animal info (fvb, mcl/mig f-1, C57BL/6).

P9979 Yoshimoto,M., Miki,K., Fink,G.D., King,A., Osborn,J.W. Chronic Angiotensin II Infusion Causes Differential Responses in Regional Sympathetic Nerve Activity in Rats. Hypertension 2010; 55(-3-):644-651. >>> Angiotensin II; Saline; Rat; 2ML2; 11 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 250-350 g.); Research Diets.

Q0274 Zhan,Y.M., Yuan,L., Kondo,M., Oettgen,P. The Counter-Regulatory Effects of ESE-1 During Angiotensin II-Mediated Vascular Inflammation and Remodeling. American Journal of Hypertension 2010; 23(-12-):1312-1317. >>> Angiotensin II; Saline; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, ApoE-/-, 5-6 mo old); peptides.

Q0601 Zhang,J.F., Villacorta,L., Chang,L., Fan,Z.Z., Hamblin,M., Zhu,T.Q., Chen,C.S., Cole,M.P., Schopfer,F.J., Deng,C.X., Garcia-Barrio,M.T., Feng,Y.H., Freeman,B.A., Chen,Y.E. Nitro-Oleic Acid Inhibits Angiotensin II-Induced Hypertension. Circulation Research 2010; 107(-4-):540-U200. >>> Nitro-oleic acid; oleic acid; angiotensin II; Polyethylene glycol; SC; Mice; 2004; 2002; ; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 8-10 weeks old); peptides; multiple pumps per animal (2); systolic and diastolic BP recordings every 4 h by radiotelemetry.

Q0410 Zhang,M., Mao,Y., Ramirez,S.H., Tuma,R.F., Chabrashvili,T. ANGIOTENSIN II INDUCED CEREBRAL MICROVASCULAR INFLAMMATION AND INCREASED BLOOD-BRAIN BARRIER PERMEABILITY VIA OXIDATIVE STRESS. Neuroscience 2010; 171(-3-):852-858. >>> Angiotensin II; SC; Mice; 2 weeks; Controls received mp w/ vehicle; animal info (6 wk old, male, C57BL/6); peptides.

P9997 Zhang,R.X., Zhang,Y.Y., Huang,X.R., Wu,Y., Chung,A.C.K., Wu,E.X., Szalai,A.J., Wong,B.C.Y., Lau,C.P., Lan,H.Y. C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II-Induced Hypertensive Cardiac Disease. Hypertension 2010; 55(-4-):953-U265. >>> Angiotensin II; SC; Mice; 2004; 28 days; Animal info (CrpTg, 8 wks old).

Q0600 Zhong,J.C., Basu,R., Guo,D., Chow,F.L., Byrns,S., Schuster,M., Loibner,H., Wang,X.H., Penninger,J.M., Kassiri,Z., Oudit,G.Y. Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction. Circulation 2010; 122(-7-):717-U40. >>> Angiotensin II; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (10 wks old, male, ACE2KO, wt); peptides.