References on the Administration of Angiotensin II Using ALZET^® Osmotic Pumps

P9196 Pedram,A., Razandi,M., Lubahn,D., Liu,J., Vannan,M., Levin,E.R. Estrogen inhibits cardiac hypertrophy: Role of estrogen receptor-beta to inhibit calcineurin. Endocrinology 2008; 149(-7-):3361-3369. >>> Angiotensin II; Saline; SC; Mice; 14 days; Controls received mp w/ vehicle; peptides; animal info (female, C57BJ/6, 10 wks old, OVX); peptides.

P9188 Shimizu,H., Nakagami,H., Osako,M.K., Hanayama,R., Kunugiza,Y., Kizawa,T., Tomita,T., Yoshikawa,H., Ogihara,T., Morishita,R. Angiotensin II accelerates osteoporosis by activating osteoclasts. FASEB Journal 2008; 22(-7-):2465-2475. >>> Angiotensin II; olmesartan; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (female, Wistar, 10 wks old).

P9140 Lin,C.X., Rhaleb,N.E., Yang,X.P., Liao,T.D., D'Ambrosio,M.A., Carretero,O.A. Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-3-):H1253-H1261. >>> Peptide, Ac-SDKP; angiotensin II; Acetic acid; saline; SC; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague Dawley, 250-300 g.); Ac-SDKP is a tetrapeptide.

P9136 Kim,C.S., Jung,S.B., Naqvi,A., Hoffman,T.A., DeRicco,J., Yamamori,T., Cole,M.P., Jeon,B.H., Irani,K. P53 Impairs Endothelium-Dependent Vasomotor Function Through Transcriptional Upregulation of P66shc. Circulation Research 2008; 103(-12-):1441-U202. >>> Angiotensin II; Acetic acid; saline; SC; Mice (transgenic); 2002; 14 days; Peptides; animal info (p66shcRNAi).

P9133 Karpanen,T., Bry,M., Ollila,H.M., Seppaenen-Laakso,T., Liimatta,E., Leskinen,H., Kivelae,R., Helkamaa,T., Merentie,M., Jeltsch,M., Paavonen,K., Andersson,L.C., Mervaala,E., Hassinen,I.E., Ylae-Herttuala,S., Oresic,M., Alitalo,K. Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy. Circulation Research 2008; 103(-9-):1018-U247. >>> Angiotensin II; SC; Mice (transgenic); 1 week; Peptide; animal info (keratin-14-VEGF-B).

P9119 Hou,Y.Z., Okada,K., Okamoto,C., Ueshima,S., Matsuo,O. Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008; 28(-7-):1257-1262. >>> Angiotensin II; Saline; SC; Mice; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (alpha2-AP def, C57BL/6, 8-10 wks old).

P9113 Miyazaki,R., Ichiki,T., Hashimoto,T., Inanaga,K., Imayama,I., Sadoshima,J., Sunagawa,K. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008; 28(-7-):1263-1269. >>> Angiotensin II; SC; Mice; 1 week; Peptides, animal info (C57BL/6, 9 wks old).

P9092 Beyer,A.M., de Lange,W.J., Halabi,C.M., Modrick,M.L., Keen,H.L., Faraci,F.M., Sigmund,C.D. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circulation Research 2008; 103(-6-):654-661. >>> Angiotensin II; Mice (transgenic); ; Peptides; animal info (C57BL/6, 4-8 months old); Research Diets D12451.

P9091 Mercure,C., Yogi,A., Callera,G.E., Aranha,A.B., Bader,M., Ferreira,A.J., Santos,R.A.S., Walther,T., Touyz,R.M., Reudelhuber,T.L. Angiotensin (1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart. Circulation Research 2008; 103(-11-):1319-U254. >>> Angiotensin II; SC; Mice (transgenic); 19 days; Controls received mp w/ saline; peptides; animal info (male, C57BL/6, 12 wks old).

P9088 Henriques,T., Zhang,X., Yiannikouris,F.B., Daugherty,A., Cassis,L.A. Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008; 28(-7-):1251-1256. >>> Dihydrotestosterone; angiotensin II; Saline; SC; Mice (knockout); 2004; 5 weeks; 28 days; Controls received mp w/ vehicle; peptides; animal info (male, female, ApoE -/-, 12 wks old, castrated).

P9081 McGuire,J.J., Van Vliet,B.N., Halfyard,S.J. Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice. BMC PHYSIOLOGY 2008; 8(-;-):U1-U12. >>> Angiotensin II; SC; Mice; 1002; 13 days; Controls received mp w/ saline; peptides; animal info (male, PAR2, +/+, -/-, 10-30 wks old, 24-30 g.).

P9080 Aragon,A.C., Goens,M.B., Carbett,E., Walker,M.K. Perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure sensitizes offspring to angiotensin II-induced hypertension. Cardiovascular Toxicology 2008; 8(-3-):145-154. >>> Angiotensin II; SC; Mice; 1002; 14 days; Controls received mp w/ NaCl; peptides; post op. care (buprenorphine); animal info (male, female, C57BL/6, 6-8 wks old).

P9071 Wang,D., Jose,P., Wilcox,C.S. beta1 receptors protect the renal afferent arteriole of angiotensin-infused rabbits from norepinephrine-induced oxidative stress. Journal of the American Society of Nephrology 2006; 17(-12-):3347-3354. >>> Angiotensin II; NaCl; SC; Rabbit; 12-14 days; Controls received mp w/ vehicle; post op. care (EMLA cream); animal info (male, New Zealand, Whit, 1.8-2.1 kg.); peptides.

P9068 Schrader,L.I., Kinzenbaw,D.A., Johnson,A.W., Faraci,F.M., Didion,S.P. IL-6 deficiency protects against angiotensin II - Induced endothelial dysfunction and hypertrophy. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007; 27(-12-):2576-2581. >>> Angiotensin II; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (C57BL/6, IL-6 deficient, NOX2 deficient); peptides.

P9067 Sato,O., Ashizawa,N., Ohtsuru,A., Imanishi,R., Kawano,H., Seto,S., Yamashita,S., Shimokawa,I., Yano,K. Fibrotic response to angiotensin II is blunted in the kidney, but not in the heart, in insulin-sensitive long-lived transgenic dwarf rats. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2007; 19(-1-):23-27. >>> Angiotensin II; Saline; acetic acid; SC; Rat (transgenic); 2002; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (Jcl: Wistar-Tgn (ARGHGEN) 1 Nts).

P9060 Ghosh,S., Chiang,P.C., Wahlstrom,J.L., Fujiwara,H., Selbo,J.G., Roberds,S.L. Oral delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 2008; 102(-5-):453-458. >>> Angiotensin II acetate; Saline; acetic acid; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 300-350 g.); peptides.

P9056 Zhang,L.N., Velichko,S., Vincelette,J., Fitch,R.M., Vergona,R., Sullivan,M.E., Croze,E., Wang,Y.X. Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice. Atherosclerosis 2008; 197(-1-):204-211. >>> Angiotensin II; SC; Mice; 2004; 4 weeks; Controls received mp w/ PBS; peptides; animal info (male, ApoE deficient).

P9035 Yamashita,H., Bharadwaj,K.G., Ikeda,S., Park,T.S., Goldberg,I.J. Cardiac metabolic compensation to hypertension requires lipoprotein lipase. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 295(-3-):E705-E713. >>> Angiotensin II; SC; Mice; 1002; 2 weeks; Controls received mp w/ saline, animal info (hLpL0).

P9034 Belmadani,S., Zerfaoui,M., Boulares,H.A., Palen,D.I., Matrougui,K. Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alpha v beta3-integrin, and TGF-beta 1 in response to ANG II and high glucose. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-1-):H69-H76. >>> Angiotensin II; SC; Mice; 2004; 4 weeks; Controls were sham operated; peptides; animal info (C57BL6/J); STZ induced diabetes.

P9032 Fukuda,D., Sata,M., Ishizaka,N., Nagai,R. Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E-deficient mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008; 28(-1-):90-96. >>> Angiotensin II; Mice; 8 weeks; Controls received mp w/ vehicle; long-term study; peptides; animal info (ApoE -/-, AT1aR -/-).

P9029 Recinos,A.III, LeJeune,W.S., Sun,H., Lee,C.Y., Tieu,B.C., Lu,M., Hou,T., Boldogh,I., Tilton,R.G., Brasier,A.R. Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice. Atherosclerosis 2007; 194(-1-):125-133. >>> Angiotensin II; SC; Mice; 7 weeks; Controls were sham operated; long-term study; pumps replaced after 4 weeks; peptides; animal info (LDLR -/-, 7 wks old).

P9028 Fukumoto,M., Takai,S., Ishizaki,E., Sugiyama,T., Oku,H., Jin,D., Sakaguchi,M., Sakonjo,H., Ikeda,T., Miyazaki,M. Involvement of Angiotensin II-Dependent Vascular Endothelial Growth Factor Gene Expression via NADPH Oxidase in the Retina in a Type 2 Diabetic Rat Model. Current Eye Research 2008; 33(-10-):885-891. >>> Angiotensin II; SC; Rat; 2004; 4 weeks; Controls received mp w/ saline; peptides; animal info (23 wks old, S12T).

P9027 Belabbas,H., Zalvidea,S., Casellas,D., Moles,J.P., Galbes,O., Mercier,J., Jover,B. Contrasting effect of exercise and angiotensin II hypertension on in vivo and in vitro cardiac angiogenesis in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 295(-5-):R1512-R1518. >>> Angiotensin II; SC; Rat; 2002; 10 days; Controls received mp w/ vehicle; peptides; animal info (Sprague Dawley, 6 wks old).

P9026 Schulz,E., Dopheide,J., Schuhmacher,S., Thomas,S.R., Chen,K., Daiber,A., Wenzel,P., Muenzel,T., Keaney,J.F. Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation 2008; 118(-13-):1347-1357. >>> Angiotensin II; NaCl; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; peptides; animal info (C57BL/6, male); incorrectly stated pump model as 1007.

P9021 Chun,T.Y., Chander,P.N., Kim,J.W., Pratt,J.H., Stier,CT Jr  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 295(-2-):E305-E312. >>> Angiotensin II; aldosterone; Ethanol; SC; Rat; 2 weeks; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); animal info (male, SHRSP/A3N, 60 days old, adrenalectomy); peptides.

P9020 Crowley,S.D., Frey,C.W., Gould,S.K., Griffiths,R., Ruiz,P., Burchette,J.L., Howell,D.N., Makhanova,N., Yan,M., Kim,H.S., Tharaux,P.L., Coffman,T.M. Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. American Journal of Physiology-Renal Physiology 2008; 295(-2-):F515-F524. >>> Angiotensin II; NaCl; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; animal info (129/SvEv. Agtrla -/-, 2-4 months old, nephrectomized); peptides.

P9019 Gonzalez-Villalobos,R.A., Seth,D.M., Satou,R., Horton,H., Ohashi,N., Miyata,K., Katsurada,A., Tran,D.V., Kobori,H., Navar,L.G. Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice. American Journal of Physiology-Renal Physiology 2008; 295(-3-):F772-F779. >>> Angiotensin II; olmesartan; SC; Mice; 1002; 12 days; Controls were sham operated; animal info (male, C57BL/6, 8-10 wks old); peptides.

P9017 Yayama,K., Miyagi,R., Sugiyama,K., Sugaya,T., Fukamizu,A., Okamoto,H. Angiotensin II regulates liver regeneration via type 1 receptor following partial hepatectomy in mice. BIOLOGICAL&PHARMACEUTICAL BULLETIN 2008; 31(-7-):1356-1361. >>> Angiotensin II; HCl; SC; Mice; 1007D; 72 hours; Controls received mp w/ vehicle; animal info (male, ddY, 8 wks old, hepatectomized); peptides.

P9014 Sarman,B., Skoumal,R., Leskinen,H., Rysa,J., Soini,Y. Nuclear factor-kappa B signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling. Journal of Hypertension 2007; 25(-9-):1927-1939. >>> Angiotensin II; Saline; acetic acid; SC; Rat; 2001; 6 days; 12 hours; Functionality of mp verified by mean arterial pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 8 wks old).

P8999 Sagara,Y., Hirooka,Y., Nozoe,M., Ito,K., Kimura,Y., Sunagawa,K. Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors. Journal of Hypertension 2007; 25(-2-):399-406. >>> Angiotensin II; phenylephrine; Y-27632; valsartan; CSF, artificial; SC; CSF/CNS; Rat; 1002; 2001; 7 days; Controls received mp w/ vehicle; enzyme inhibitor (Rho-kinase); antihypertensive; peptides; animal info (male, Wistar-Kyoto, SHR, 280-340 g.); catheter tip placement and connection confirmed.

P8984 Flamant,M., Placier,S., Rodenas,A., Curat,C.A., Vogel,W.F., Chatziantoniou,C., Dussaule,J.C. Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease. Journal of the American Society of Nephrology 2006; 17(-12-):3374-3381. >>> Angiotensin II; SC; Mice (transgenic); 4, 6 weeks; Functionality of mp verified by systolic blood pressure; pumps replaced; peptides; animal info (male, 129/Sv x CD1, wt, DDR1 -/-, 4-6 months old, 30-35 g.); nephrology; long-term study; pump model incorrectly stated as 1004.

P8978 Ebrahimian,T., Sairam,M.R., Schiffrin,E.L., Touyz,R.M. Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-4-):H1481-H1488. >>> Angiotensin II; SC; Mice; 14 days; Controls received mp w/ saline; cardiovascular; peptides; animal info (129T2 (wt), FORKO, female, 20-24 wks old).

P8977 Antonello,M., Montemurro,D., Bolognesi,M., Di Pascoli,M., Piva,A., Grego,F., Sticchi,D., Giuliani,L., Garbisa,S., Rossi,G.P. Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts. American Journal of Hypertension 2007; 20(-12-):1321-1328. >>> Angiotensin II; NaCl; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague Dawley, 13 wks old, 250-350 g.).

P8975 Rugale,C., Delbosc,S., Mimran,A., Jover,B. Simvastatin reverses target organ damage and oxidative stress in angiotensin II hypertension: Comparison with apocynin, tempol, and hydralazine. Journal of Cardiovascular Pharmacology 2007; 50(-3-):293-298. >>> Angiotensin II; SC; Rat; 2004; 17 days; Controls received mp w/ distilled water; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 260-280 g.).

P8970 Johar,S., Cave,A.C., Narayanapanicker,A., Grieve,D.J., Shah,A.M. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB Journal 2006; 20(-9-):U291-U299. >>> Angiotensin II; aldosterone; SC; Mice; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; replacement therapy (nephrectomy); cardiovascular; peptides; animal info (male, C57BL6/J, wt, Nox2 -/-).

P8962 Rysa,J., Aro,J., Ruskoaho,H. Early left ventricular gene expression profile in response to increase in blood pressure. Blood Pressure 2006; 15(-6-):375-383. >>> Angiotensin II; losartan; Saline; SC; Rat; 2 weeks, 3 days; 6, 12 hours; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague Dawley, 3 months old, 250-300 g.).

P8961 Danchuk,S., Sukhanov,S., Horvat,D., Uddin,M.N., Puschett,J.B. Effects of resibufogenin in experimental hypertension. American Journal of Nephrology 2008; 28(-1-):8-13. >>> Angiotensin II; SC; Rat; 2002; 13 days; Controls received sham surgery; functionality of mp verified by systolic blood pressure; replacement therapy (nephrectomy); peptides; animal info (male, CD, 300-350 g.); nephrology.

P8950 Huskova,Z., Kramer,H.J., Thumova,M., Vanourkova,Z., Buergelova,M., Teplan,V., Maly,J., Cervenka,L. Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats. KIDNEY&BLOOD PRESSURE RESEARCH 2006; 29(-2-):74-83. >>> Angiotensin II; SC; Rat; 2002; 14 days; Cardiovascular; peptides; animal info (male, HanSD, 39 days old); nephrology.

P8945 Mustonen,E., Aro,J., Puhakka,J., Ilves,M., Soini,Y., Leskinen,H., Ruskoaho,H., Rysae,J. Thrombospondin-4 expression is rapidly upregulated by cardiac overload. Biochemical and Biophysical Research Communications 2008; 373(-2-):186-191. >>> Angiotensin II; losartan; NaCl; SC; Rat; ; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague Dawley); myocardial infarction by coronary artery ligation.

P8939 Morris,J.B., Olzinski,A.R., Bernard,R.E., Aravindhan,K., Mirabile,R.C., Boyce,R., Willette,R.N., Jucker,B.M. p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis - MRI assessment. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2008; 28(-2-):265-271. >>> Angiotensin II; SC; Mice (knockout); 2004; 21 days; Controls received mp w/ saline; peptides; post op. care (banamine); animal info (male, ApoE -/-).

P8936 Kobayashi,T., Nogami,T., Taguchi,K., Matsumoto,T., Kamata,K. Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK. British Journal of Pharmacology 2008; 155(-7-):974-983. >>> Angiotensin II; SC; Rat; 2ML2; 2 weeks; Controls were not diabetic; peptides; animal info (male, Wistar, 17 wks old); STZ-induced diabetes.

P8921 Jacobi,J., Maas,R., Cordasic,N., Koch,K., Schmieder,R.E., Boeger,R.H., Hilgers,K.F. Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H1058-H1066. >>> Angiotensin II; PBS; SC; Mice (transgenic); 2004; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; dose-response (fig. 5); stress/adverse reaction: (see pg. H1060) 3 animals died (1 after 2 wks with no signs of infection or infarction, 2 after 4+6 days with intrathoracic hemorrhage); cardiovascular; peptide; animal info (C57BL/6J, wt, DDAH1, Tg, male, 4 months old).

P8903 Zhang,L.N., da Cunha,V., Martin-McNulty,B., Rutledge,J., Vergona,R., Sullivan,M.E., Wang,Y.X.J. Monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha; a deficiency does not affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model. CARDIOVASCULAR PATHOLOGY 2007; 16(-4-):231-236. >>> Angiotensin II; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; ischemia (cardiac); animal info (male, C57BL/6, MCP-1, MIP-1a-deficient, 6 months); common left carotid artery ligation.

P8897 Ishizaka,N., Matsuzaki,G., Saito,K., Noiri,E., Mori,I., Nagai,R. Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat. LABORATORY INVESTIGATION 2006; 86(-12-):1285-1292. >>> Angiotensin II, Val5-; norepinephrine; SC; Rat; 2001; 7 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 250-300 g.); nephrology.

P8890 Hobara,N., Goda,M., Yoshida,N., Takatori,S., Kitamura,Y., Mio,M., Kawasaki,H. Angiotensin II type 2 receptors facilitate reinnervation of phenol-lesioned vascular calcitonin gene-related peptide-containing nerves in rat mesenteric arteries. Neuroscience 2007; 150(-3-):730-741. >>> Angiotensin II; nerve growth factor; PD123319; losartan; Saline; water; IP; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; peptides; post op. care (penicillin); animal info (8 wks old, Wistar).

P8830 King,V.L., Cassis,L.A., Daugherty,A. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. American Journal of Pathology 2007; 171(-6-):2040-2047. >>> Angiotensin II; Saline, sterile; SC; Mice; 28 days; Controls received mp w/ vehicle; cardiovascular; animal info (male, C57BL/6, apoE -/-, IL-4 +/+ or -/-, 8 wks old).

P8795 Takata,Y., Liu,J., Yin,F., Collins,A.R., Lyon,C.J., Lee,C.H., Atkins,A.R., Downes,M., Barish,G.D., Evans,R.M., Hsueh,W.A., Tangirala,R.K. PPAR delta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-11-):4277-4282. >>> Angiotensin II; PBS; SC; Mice; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by blood pressure; animal info (LDLR -/-, 3 mos); pump model not specified.

P8787 Sharma,U., Rhaleb,N.E., Pokharel,S., Harding,P., Rasoul,S., Peng,H.M., Carretero,O.A. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-3-):H1226-H1232. >>> Angiotensin II; peptide, Ac-SDKP; Saline; acetic acid; SC; Mice; 2004; 8 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; long-term study; pumps replaced after 4 weeks; cardiovascular; peptides; animal info (male, C57BL6/J, 12-14 wks old).

P8781 Graciano,M.L., Nishiyama,A., Jackson,K., Seth,D.M., Ortiz,R.M., Prieto-Carrasquero,M.C., Kobori,H., Navar,L.G. Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. American Journal of Physiology-Renal Physiology 2008; 294(-1-):F161-F169. >>> Angiotensin II; SC; Rat; 14 days; Controls received sham surgery; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 200-250g.).

P8772 Franco,M., Bautista,R., Perez-Mendez,O., Gonzalez,L., Pacheco,U., Sanchez-Lozada,L.G., Santamaria,J., Tapia,E., Monreal,R., Martinez,F. Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats. American Journal of Physiology-Renal Physiology 2008; 294(-1-):F84-F92. >>> Angiotensin II; Ringer's solution, lactated; SC; Rat; 2002; 14 days; Controls received sham; dose-response (fig. 1); cardiovascular; peptides; animal info (male, Wistar, 350-360g.).

P8770 Pearse,D.D., Tian,R.X., Nigro,J., Iorgulescu,J.B., Puzis,L., Jaimes,E.A. Angiotensin II increases the expression of the transcription factor ETS-1 in mesangial cells. American Journal of Physiology-Renal Physiology 2008; 294(-5-):F1094-F1100. >>> Angiotensin II; PBS; SC; Rat; 1007D; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague Dawley, 6 wks old).

P8766 King,A.J., Novotny,M., Swain,G.M., Fink,G.D. Whole body norepinephrine kinetics in ANG II-salt hypertension in the rat. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-4-):R1262-R1267. >>> Angiotensin II; SC; Rat; 2ML2; 14 days; Functionality of mp verified by mean arterial blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 225-250g.).

P8760 Yao,F.R., Sumners,C., O'Rourke,S.T., Sun,C.W. Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-6-):H2712-H2720. >>> Angiotensin II; CSF/CNS; Rat; 1002; 2 weeks; Controls received mp w/ physiological saline; cardiovascular; peptides; animal info (male, Sprague Dawley 270-320g).

P8749 Ihara,Y., Egashira,K., Nakano,K., Ohtani,K., Kubo,M., Koga,J.I., Iwai,M., Horiuchi,M., Gang,Z., Yamagishi,S.I., Sunagawa,K. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):455-464. >>> Angiotensin II; Mice; 1 week; Cardiovascular; peptides; animal info (male, ApoE -/-, 15-16 weeks old, 25g); diabetes.

P8748 Kilic,A., Bubikat,A., Gassner,B., Baba,H.A., Kuhn,M. Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling. Endocrinology 2007; 148(-9-):4162-4169. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by arterial blood pressure; cardiovascular; peptides; animal info (CM GC-A KO, wt; male, female, 8-12 weeks old).

P8745 Wakisaka,O., Takahashi,N., Shinohara,T., Ooie,T., Nakagawa,M., Yonemochi,H., Hara,M., Shimada,T., Saikawa,T., Yoshimatsu,H. Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72. Journal of Molecular and Cellular Cardiology 2007; 43(-5-):616-626. >>> Angiotensin II; SC; Rat; 2ML4; 28 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; no stress (see pg. 624); cardiovascular; peptides; animal info (male, Sprague-Dawley, 250-300g); "In our continuous AII infusion model, no overt heart failure was observed." (p. 624).

P8730 McBryde,F.D., Guild,S.J., Barrett,C.J., Osborn,J.W., Malpas,S.C. Angiotensin II-based hypertension and the sympathetic nervous system: the role of dose and increased dietary salt in rabbits. Experimental Physiology 2007; 92(-5-):831-840. >>> Angiotensin II; IV (jugular); Rabbit; 2ML4; 3 weeks; Functionality of mp verified by mean arterial pressure; dose-response (fig. 1); cardiovascular; peptides; animal info (New Zealand White, 2.4-3.5 kg).

P8721 Saji,K., Fukumoto,Y., Suzuki,J., Fukui,S., Nawata,J., Shimokawa,H. Colchicine, a microtubule depolymerizing agent, inhibits myocardial apoptosis in rats. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 2007; 213(-2-):139-148. >>> Angiotensin II; Acetic acid; saline; SC; Rat; 2002; 16-24 hours; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides; animal info (male, Wistar).

P8715 Cao,R.Y., Adams,M.A., Habenicht,A.J., Funk,C.D. Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. PROSTAGLANDINS&OTHER LIPID MEDIATORS 2007; 84(-1-2-):34-42. >>> Angiotensin II; SC; Mice; 2004; 28 days; Functionality of mp verified by residual volume analysis; blood pressure taken; cardiovascular; peptides; animal info (male, 8 weeks old).

P8709 Wen,J., Wang,P.Y., Smith,S.V., Haller,C.A., Chaikof,E.L. Syndecans are differentially expressed during the course of aortic aneurysm formation. JOURNAL OF VASCULAR SURGERY 2007; 46(-5-):1014-1025. >>> Angiotensin II; SC; Mice; 1002; 2004; 1, 4, 8 weeks; funtionality of mp verified by systolic blood pressure; long-term study; pumps replaced after 4 weeks; cardiovascular; peptides; animal info (male, C57BL/6, ApoE -/-, 8 wks old).

P8667 Purcell,N.H., Wilkins,B.J., York,A., Saba-El-Leil,M.K., Meloche,S., Robbins,J., Molkentin,J.D. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-35-):14074-14079. >>> Isoproterenol; angiotensin II; Saline; SC; Mice; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (Erk1 null).

P8633 Chan,S.H.H., Wang,L.L., Tseng,H.L., Chan,J.Y.H. Upregulation of AT1 receptor gene on activation of protein kinase C beta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla. Journal of Hypertension 2007; 25(-9-):1845-1861. >>> Angiotensin II; CSF, artificial; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; comparison of ICV microinjections vs. mp; cardiovascular; peptides; post op. care (procaine penicillin); animal info (male, Sprague-Dawley, 200-280g).

P8624 Guan,Y., Zhang,Y.H., Wu,J., Qi,Z.H., Yang,G.R., Dou,D., Gao,Y.S., Chen,L.H., Zhang,X.Y., Davis,L.S., Wei,M.F., Fan,X.F., Carmosino,M., Hao,C., Imig,J.D., Breyer,R.M., Breyer,M.D. Anti hypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. Journal of Clinical Investigation 2007; 117(-9-):2496-2505. >>> Angiotensin II; Saline, sterile; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; comparison of IV acute infusion; cardiovascular; peptides; animal info (male, N10 129S6/SvEvTac Ep1 t/t, -/-).

P8621 Rao,P., Huang,Z.H., Mazzone,T. Angiotensin II regulates adipocyte apolipoprotein E expression. Journal of Clinical Endocrinology and Metabolism 2007; 92(-11-):4366-4372. >>> Angiotensin II; SC; Mice; 3 days; Controls received mp w/ sterile PBS; no stress (see pg. 4367); peptides; animal info (C57BL/6, 8 weeks old); endocrinology.

P8616 LI,X.C., Navar,L.G., SHAO,Y., Zhuo,J.L. Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice. American journal of physiology.Renal physiology 2007; 293(--):F586-F593. >>> Angiotensin II; IP; Mice; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; peptides; animal info (male, C57BL/6J, 25 grams, 10 weeks old).

P8615 Coles,B., Fielding,C.A., Rose-John,S., Scheller,J., Jones,S.A., O'Donnell,V.B. Classic Interleukin-6 Receptor Signaling and Interleukin-6 trans-Signaling Differentially Control Angiotensin II-Dependent Hypertension, Cardiac Signal Transducer and Activator of Transcription-3 Activation, and Vascular Hypertrophy in Vivo. American Journal of Pathology 2007; 171(-1-):315-325. >>> Angiotensin II; Saline; SC; Mice; 1002; 7 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; no stress (see pg. 317); cardiovascular; peptides; animal info (male, C57BL/6J wt or IL-6 -/-, 25-30 grams, 10-12 weeks old).

P8605 Ozawa,Y., Kobori,H. Crucial role of Rho-nuclear factor-kappa B axis in angiotensin II-induced renal injury. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F100-F109. >>> Angiotensin II; SC; Rat; 12 days; Controls received sham operation; functionality of mp verified by systolic blood pressure; cardiovascular; animal info (male, Sprague-Dawley, 250 grams).

P8604 Ortiz,R.M., Graciano,M.L., Seth,D., Awayda,M.S., Navar,L.G. Aldosterone receptor antagonism exacerbates intrarenal angiotensin II augmentation in ANG II-dependent hypertension. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F139-F147. >>> Angiotensin II; Rat; 2004; 28 days; Controls received sham operation; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 200-225 grams); radiotelemetry devices surgically implanted 5 days before mp.

P8600 de Seigneux,S., Nielsen,J., Olesen,E.T.B., Dimke,H., Kwon,T.H., Frokiaer,J., Nielsen,S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; 6,7,8 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

P8598 Ding,L., Chapman,A., Boyd,R., Wang,H.D. ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension. American Journal of Physiology- Heart and Circulatory Physiology 2007; 292(-6-):H2997-H3005. >>> Angiotensin II; Saline; acetic acid; SC; Rat; 6 days; Controls received mp w/ vehicle; systolic blood pressure measured; cardiovascular; peptides; animal info (male, Sprague-Dawley, 12-14 weeks old, 350-450 grams).

P8595 Lu,H., Boustany-Kari,C.M., Daugherty,A., Cassis,L.A. Angiotensin II increases adipose angiotensinogen expression. American Journal of Physiology- Endocrinology And Metabolism 2007; 292(-5-):E1280-E1287. >>> Angiotensin II; losartan; Saline; SC; Mice; 2001; 2004; 7,28 days; Controls received mp w/ vehicle; cardiovascular; peptides; endocrinology; animal info (male, C57BL/6, 6-8 weeks old).

P8589 Franco,M., Martinez,F., Quiroz,Y., Galicia,O., Bautista,R., Johnson,R.J., Rodriguez-Iturbe,B. Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol 2007/7; 293(-1-):R251-R256. >>> Angiotensin II; SC; Rat; 2002; 2 weeks; Functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 340-360 grams); nephrology.

P8573 Hilgers,R.H.P., Webb,R.C. Reduced expression of SKCa and IKCa channel proteins in rat small mesenteric arteries during angiotensin II-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-5-):H2275-H2284. >>> Angiotensin II; SC; Rat; 1,14 days; Controls received mp w/ saline; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (Sprague-Dawley, 225-250 grams); "We have chosen the experimental model of chronic Ang II infusion using an osmotic minipump...this model of hypertension enables us to study the effect of a sudden drastic rise in blood pressure at adult age on changes in the expression of SKCa and IKCa channels in small resistance sized arteries." (p. H2279).

P8556 Nouri,P., Gill,P., Li,M., Wilcox,C.S., Welch,W.J. p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-4-):H1685-H1689. >>> Angiotensin II; Saline; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley, 8-10 weeks old, 253-399 grams).

P8549 Henke,N., Schmidt-Ullrich,R., Dechend,R., Park,J.K., Qadri,F., Wellner,M., Obst,M., Gross,V., Dietz,R., Luft,F.C., Scheidereit,C., Muller,D.N. Vascular endothelial cell-specific NF-kappa B suppression attenuates hypertension-induced renal damage. Circulation Research 2007; 101(-3-):268-276. >>> Angiotensin II; Mice (transgenic); mice; 14 days; Cardiovascular; peptides; animal info (C57BL/6, 8 weeks old).

P8546 Satoh,M., Matter,C.M., Ogita,H., Takeshita,K., Wang,C.Y., Dorn,G.W., Liao,J.K. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation 2007/6/26; 115(-25-):3197-3204. >>> Angiotensin II; SC; Mice; mice (transgenic); 2004; ; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, FVB wt or Gq Tg, 8 weeks old, 30-35 grams).

P8540 Mueller,H., Schweitzer,N., Joehren,O., Dominiak,P., Raasch,W. Angiotensin II stimulates the reactivity of the pituitary-adrenal axis in leptin-resistant Zucker rats, thereby influencing the glucose utilization. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 293(-3-):E802-E810. >>> Angiotensin II; Saline; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; dose-response (fig. 4); peptides; animal info (male, obese Zucker, 300 grams, lean Zucker, 190 grams); endocrinology.

P8534 Ni,W., Zhan,Y., He,H., Maynard,E., Balschi,J.A., Oettgen,P. Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47phox gene expression in response to angiotensin II. Circulation Research 2007; 101(-10-):985-994. >>> Angiotensin II; Ets-1, dominant negative peptide; peptide, Ets-1, mutated; Saline; SC; Mice; 2 weeks; Controls received mp w/ vehicle or mutant control peptide; cardiovascular; peptides; multiple pumps per animal (2); animal info (C57BL/6, wt or Ets-1 -/-); peptide presence in thoracic aorta confirmed by immunoflorescence; DN-Ets-1 peptide biotin linked and HIV-TAT (48-60) linked.

P8530 Hasegawa,K., Wakino,S., Tatematsu,S., Yoshioka,K., Homma,K., Sugano,N., Kimoto,M., Hayashi,K., Itoh,H. Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase. Circulation Research 2007; 101(-2-):E2-E10. >>> Arginine, asymmetric dimethyl; angiotensin II; SC; Mice; 2004; 2,4 weeks; Controls received mp w/ saline; enzyme inhibitor (NO synthase); cardiovascular; peptides; animal info (male, C57BL/6, wt, DDAH2; Tg, 8 weeks old).

P8524 Jiang,F., Jones,G.T., Dusting,G.J. Failure of antioxidants to protect against angiotensin II-induced aortic rupture in aged apolipoprotein(E)-deficient mice. British Journal of Pharmacology 2007; 152(-6-):880-890. >>> Angiotensin II; losartan; SC; Mice; 4 weeks; Controls received mp w/ saline; functionality of mp verified by systolic blood pressure; no stress (see pg. 882); cardiovascular; peptides; animal info (male, ApoE -/-, 50-60 weeks old, 30 grams).

P8505 Yurovsky,V.V., Gerzanich,V., Ivanova,S., Dong,Y., Tsymbalyuk,O., Simard,J.M. Autocrine TGF-beta1 mediates angiotensin II-Induced proliferative response of cerebral vessels in vivo. American Journal of Hypertension 2007; 20(-9-):950-956. >>> Angiotensin II; oligodeoxynucleotide, antisense; Saline; SC; CSF/CNS (intrathecal, cisterna magna); Rat; 2001; 2004; 4-28 days; Controls received mp w/ vehicle; blood pressure taken; antisense (TGF, beta); cardiovascular; peptides; second pump placed IT to deliver ODN.

P8500 Xue,B.J., Pamidimukkala,J., Lubahn,D.B., Hay,M. Estrogen receptor-alpha mediates estrogen protection from angiotensin II- induced hypertension in conscious female. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-4-):H1770-H1776. >>> Angiotensin II; Estradiol, 17B-; ICI-182,780; CSF/CNS; SC; Mice; 1002; ; Blood pressure measured; cardiovascular; ALZET brain infusion kit used; peptides; animal info (OVX, WT, and ER knockout); CNS group delivered E2 + ICI.

P8499 Tsai,C.T., Wang,D.L., Chen,W.P., Hwang,J.J., Hsieh,C.S., Hsu,K.L., Tseng,C.D., Lai,L.P., Tseng,Y.Z., Chiang,F.T., Lin,J.L. Angiotensin II increases expression of alpha 1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element- binding protein-dependent pathway in HL-1 myocytes. Circulation Research 2007; 100(-10-):1476-1485. >>> Angiotensin II; Water; SC; Rat; 3,7 days; 6 hours; Comparison of IP injections vs. mp; cardiovascular; peptides; animal info (Wistar, 300 g).

P8462 Suzuki,K., Han,G.D., Miyauchi,N., Hashimoto,T., Nakatsue,T., Fujioka,Y., Koike,H., Shimizu,F., Kawachi,H. Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. American Journal of Pathology 2007; 170(-6-):1841-1853. >>> Angiotensin II; PD123319; CGP42112A; Water, distilled; SC; Rat; 15 days; 24,72 hours; Controls received mp w/ vehicle; peptides; animal info (Female, Brown Norway, 100-110g, 7-8 wks old); nephrology.

P8459 De Ciuceis,C., Amiri,F., Iglarz,M., Cohn,J.S., Touyz,R.M., Schiffrin,E.L. Synergistic vascular protective effects of combined low doses of PPAR alpha and PPAR gamma activators in angiotensin II-induced hypertension in rats. British Journal of Pharmacology 2007; 151(-1-):45-53. >>> Angiotensin II; Saline; SC; Rat; 7 days; Controls received mp w/ vehicle: no stress (see pg. 47); cardiovascular; peptides; animal info (male, Sprague-Dawley, 200-225g).

P8453 Evans,R.G., Burke,S.L., Lambert,G.W., Head,G.A. Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2007; 293(-3-):R1247-R1256. >>> Angiotensin II; SC; Rabbit; 2ML4; 4-6 weeks; Controls received sham; pumps replaced after 22 days; peptides; animal info (New Zealand White, 2.8 kg).

P8451 Ideura,H., Hiromura,K., Hiramatsu,N., Shigehara,T., Takeuchi,S., Tomioka,M., Sakairi,T., Yamashita,S., Maeshima,A., Kaneko,Y., Kuroiwa,T., Kopp,J.B., Nojima,Y. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy. American Journal of Physiology-Renal Physiology 2007; 293(-4-):F1214-F1221. >>> Angiotensin II; norepinephrine; SC; Mice (transgenic); 2004; 16 days; Functionality of mp verified by blood pressure; cardiovascular; peptides; animal info (FVB/N Podocin/rt TA tg, 7-8 wks old, 20-25g) nephrology.

P8450 Jackman,K.A., Woodman,O.L., Chrissobolis,S., Sobey,C.G. Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Research 2007; 1141(--):99-107. >>> Angiotensin II; Acetic acid; SC; Rat; 14 days; Functionality of mp verified by mean arterial pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 260-440g).

P8445 Baurand,A., Zelarayan,L., Betney,R., Gehrke,C., Dunger,S., Noack,C., Busjahn,A., Huelsken,J., Taketo,M.M., Birchmeier,W., Dietz,R., Bergmann,M.W. Beta-Catenin downregulation is required for adaptive cardiac remodeling. Circulation Research 2007; 100(-9-):1353-1362. >>> Angiotensin II; Saline; acetic acid; SC; Mice (transgenic); 1002; 12-14 days; Cardiovascular; peptides; animal info (C57BL/6, FVB background, 10-14 wks old).

P8431 Pan,Y.X., Gao,L., Wang,W.Z., Zheng,H., Liu,D.M., Patel,K.P., Zucker,I.H., Wang,W. Exercise training prevents arterial baroreflex dysfunction in rats treated with central angiotensin II. Hypertension 2007; 49(-3-):519-527. >>> Angiotensin II; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ aCSF; cardiovascular; ALZET brain infusion kit II used; peptides; animal info (male, Sprague-Dawley, 300-310g.); cannula placement confirmed with chicago blue dye.

P8430 King,A.J., Fink,G.D. Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms. Hypertension 2006; 48(-5-):927-933. >>> Angiotensin II; Saline, physiological; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley, 225-250g.).

P8427 Imanishi,T., Kobayashi,K., Kuroi,A., Mochizuki,S., Goto,M., Yoshida,K., Akasaka,T. effects of angiotensin II on NO bioavailability evaluated using a catheter-type NO sensor. Hypertension 2006; 48(-6-):1058-1065. >>> Angiotensin II, human; Saline; SC; Rabbit; 14 days; 24 hours; Controls received mp w/ vehicle; dose-response (fig. 2); cardiovascular; peptides; animal info (male, New Zealand White, 2-2.5 kg.).

P8418 Kang,K.T., Sullivan,J.C., Sasser,J.M., Imig,J.D., Pollock,J.S. Novel nitric oxide synthase-dependent mechanism of vasorelaxation in small arteries from hypertensive rats. Hypertension 2007; 49(-4-):893-901. >>> Angiotensin II; SC; Rat; 2 weeks; Functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 220-250g.).

P8407 Pradhan,A., Umezu,M., Fukagawa,M. Heme-oxygenase upregulation ameliorates angiotensin II-induced tubulointerstitial injury and salt-sensitive hypertension. American Journal of Nephrology 2006; 26(-6-):552-561. >>> Angiotensin II; Ringer's solution, lactated; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 200-250g.); Nephrology.

P8401 Masuyama,H., Tsuruda,T., Kato,J., Imamura,T., Asada,Y., Stasch,J.P., Kitamura,K., Eto,T. Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats. Hypertension 2006; 48(-5-):972-978. >>> Angiotensin II; SC; Rat; 2002; 14 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Wistar, 8 wks old, 200-250g).

P8395 Zhao,W.Y., Swanson,S.A., Ye,J.F., Li,X.L., Shelton,J.M., Zhang,W.G., Thomas,G.D. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 2006; 48(-4-):637-643. >>> Angiotensin II; norepinephrine; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle, or sham surgery; cardiovascular; peptides; animal info (Sprague-Dawley, 200-300g., unilateral renal artery stenosis).

P8392 Yang,L., Zou,X.J., Liang,Q.S., Chen,H., Feng,J., Yan,L., Wang,Z.H., Zhou,D.X., Li,S.S., Ya,S.L., Zheng,Z. Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway. EXPERIMENTAL AND MOLECULAR MEDICINE 2007; 39(-1-):65-73. >>> Angiotensin II; Saline; SC; Rat; 3 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; animal info (Wistar, 200-300g.).

P8356 Nieves-Cintron,M., Amberg,G.C., Nichols,C.B., Molkentin,J.D., Santana,L.F. Activation of NFATc3 down-regulates the beta 1subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension. Journal of Biological Chemistry 2007; 282(-5-):3231-3240. >>> Angiotensin II; Saline; SC; Mice; 5-7 days; Controls received mp w/ vehicle; functionality of mp verified by systolic and diastolic BP; cardiovascular; peptides; animal info (BALB/C).

P8354 Burke,S.L., Head,G.A., Lambert,G.W., Evans,R.G. Renal sympathetic neuroeffector function in renovascular and angiotensin II-dependent hypertension in rabbits. Hypertension 2007; 49(-4-):932-938. >>> Angiotensin II; SC; Rabbit; 2ML4; 4-6 weeks; Controls received sham surgery; functionality of mp verified by blood pressure; pumps replaced after 22 days; cardiovascular; peptides; animal info (male, New Zealand white, 2.8 kg).

P8347 Virdis,A., Colucci,R., Fornai,M., Duranti,E., Giannarelli,C., Bernardini,N., Segnani,C., Ippolito,C., Antonioli,L., Blandizzi,C., Taddei,S., Salvetti,A., Del Tacca,M. Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice. Hypertension 2007; 49(-3-):679-686. >>> Angiotensin II; Saline, physiological; SC; Mice; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; no stress (see pg. 682); cardiovascular; peptides; animal info (male, DBA/1N, 12-14 weeks old, 25 grams).

P8340 Sarr,M., Chataigneau,M., Martins,S., Schott,C., El Bedoui,J., Oak,M.H., Muller,B., Chataigneau,T., Schini-Kerth,V.B. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase. Cardiovascular Research 2006; 71(-4-):794-802. >>> Angiotensin II; Saline; acetic acid; SC; Rat; 2004; 14 days; Controls received sham operation; functionality of mp verified by systolic blood pressure; cardiovascular; animal info (male, Wistar, 12-15 weeks old).

P8335 Zhang,G.X., Ohmori,K., Nagai,Y., Fujisawa,Y., Nishiyama,A., Abe,Y., Kimura,S. Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. Journal of Molecular and Cellular Cardiology 2007; 42(-4-):804-811. >>> Isoproterenol; angiotensin II; Saline; SC; Mice; 2002; 11 days; Controls received mp w/ vehicle; no stress (see pg. 805); cardiovascular; peptides; animal info (male, C57BL/6, 25 grams, 10 weeks old, male, 11 weeks old, 25-30 grams).

P8312 Martin-McNulty,B., Zhang,L.N., da Cunha,V., Vincelette,J., Rutledge,J.C., Vergona,R., Sullivan,M.E., Wang,Y.X. Urokinase-type plasminogen activator deficiency (uPA-KO) prevented carotid artery ligation-induced vascular remodeling in mice. Translational Research 2007; 149(-2-):70-75. >>> Angiotensin II; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (C57BL/6J, wt or uPA-KO, 6 months old, common carotid artery dissection/ligation).

P8257 Elmarakby,A.A., Williams,J.M., Imig,J.D., Pollock,J.S., Pollock,D.M. Synergistic actions of enalapril and ternpol during chronic angiotensin II-induced hypertension. VASCULAR PHARMACOLOGY 2007; 46(-2-):144-151. >>> Angiotensin II; icatibant; SC; Rat; 2002; 14 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; multiple pumps per per animal (2); animal info (male, Sprague-Dawley, 200-250g.).

P8232 Cui,R.W., Tieu,B., Recinos,A., Tilton,R.G., Brasier,A.R. RhoA mediates angiotensin II-induced phospho-Ser536 nuclear factor kappa B/Re1A subunit exchange on the interleukin-6 promoter in VSMCs. Circulation Research 2006; 99(-7-):723-730. >>> Angiotensin II; Saline; Rat; 10 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (Sprague-Dawley, 250 grams).

P8231 Crowley,S.D., Gurley,S.B., Herrera,M.J., Ruiz,P., Griffiths,R., Kumar,A.P., Kim,H.S., Smithies,O., Le,T.H., Coffman,T.M. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-47-):17985-17990. >>> Angiotensin II; SC; Mice; 2004; 28 days; Mean arterial pressure, mean BP taken; no stress (see pg. 17988); cardiovascular; peptides; animal info (C57BL/6, AT1A -/-, male, 2-4 months old, kidney transplantation).

P8228 Cheng,C., Tempel,D., van Haperen,R., van der Baan,A., Grosveld,F., Daemen,M.J.A.P., Krams,R., de Crom,R. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 2006; 113(-23-):2744-2753. >>> Angiotensin II; SC; Mice; 2004; 2 weeks; Functionality of mp verified by mean blood pressure; cardiovascular; peptides; animal info (Apo E -/-).

P8227 Cassis,L.A., Rateri,D.L., Lu,H., Daugherty,A. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007; 27(-2-):380-386. >>> Angiotensin II; Saline; Mice; 2004; 28 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, C57BL/6, 9 weeks old, 27 grams); bone marrow transplantation, irradiation.

P8213 Castoldi,G., di Gioia,C.R.T., Travaglini,C., Busca,G., Redaelli,S., Bombardi,C., Stella,A. Angiotensin II increases tissue-specific inhibitor of metalloproteinase-2 expression in rat aortic smooth muscle cells in vivo: Evidence of a pressure-independent effect. Clinical and Experimental Pharmacology and Physiology 2007; 34(-3-):205-209. >>> Angiotensin II; SC; Rat; 2001; 1 week; Controls received mp w/ saline; cardiovascular; peptides; animal info (male, Sprague-Dawley, 12 wk old, 225-250g., Renovascular hypertensive).

P8201 Grobe,J.L., Mecca,A.P., Lingis,M., Shenoy,V., Bolton,T.A., Machado,J.M., Speth,R.C., Raizada,M.K., Katovich,M.J. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-2-):H736-H742. >>> Angiotensin II; angiotensin (1-7); angiotensin (1-7), D-ALa7-; SC; Rat; 2004; 4 weeks; Controls received sham treatment; cardiovascular; peptides; multiple pumps per animal (2); animal info (male, Sprague-Dawley, 270-300g.).

P8193 Ye,T., Liu,Z.Q., Sun,C.F., Zheng,Y., Ma,A.Q., Fang,Y. Altered expression of renal bumetanide-sensitive sodium-potassium-2 chloride cotransporter and Cl- channel -K2 gene on angiotensin II-infused hypertensive rats. Chinese Medical Journal 2005; 118(-23-):1945-1951. >>> Angiotensin II; Saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; no stress (see pg. 1947); cardiovascular; peptides; post op. care (Penicillin G); animal info (male, Sprague-Dawley, 260-320 grams); nephrology.

P8190 Thomas,M.C., Tikellis,C., Burns,W.M., Bialkowski,K., Cao,Z.M., Coughlan,M.T., Jandeleit-Dahm,K., Cooper,M.E., Forbes,J.M. Interactions between renin angiotensin system and advanced glycation in the kidney. Journal of the American Society of Nephrology 2005; 16(-10-):2976-2984. >>> Albumin, rat serum; albumin, rat serum, AGE-modified; angiotensin II; PBS; sodium chloride; acetic acid; SC; Rat; 2002; 14, 28 days; Controls received mp w/ vehicle or rat serum albumin; peptides; animal info (male, Sprague-Dawley, 8-9 weeks old, 200-250 grams); advanced glycation end products (AGE); nephrology; diabetic.

P8185 Neves,M.F., Amiri,F., Virdis,A., Diep,Q.N., Schiffrin,E.L. Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy. Canadian Journal of Physiology and Pharmacology 2005; 83(-11-):999-1006. >>> Angiotensin II, Ile5-; Saline; SC; Rat; 2 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (Sprague-Dawley, male, 250-300 grams).

P8168 Fitch,R.M., Rutledge,J.C., Wang,Y.X., Powers,A.F., Tseng,J.L., Clary,T., Rubanyi,G.M. Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice. American Journal of Physiology-Heart and Circulatory Physiology 2006; 290(-3-):H1190-H1198. >>> Angiotensin II; SC; Mice; 2004; 28 days; Controls received no treatment; cardiovascular; peptides; animal info (male, C57BL/6J, 6 months old).

P8146 Kunieda,T., Minamino,T., Nishi,J.I., Tateno,K., Oyama,T., Katsuno,T., Miyauchi,H., Orimo,M., Okada,S., Takamura,M., Nagai,T., Kaneko,S., Komuro,I. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006; 114(-9-):953-960. >>> Angiotensin II; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (C57BL/6, 4-6 months old).

P8138 Iwanaga,Y., Kihara,Y., Takenaka,H., Kita,T. Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-anglotensin type 1 receptor system. Journal of Molecular and Cellular Cardiology 2006; 41(-5-):798-806. >>> Angiotensin II; Saline; SC; Rat; 2001D; 24 hours; Controls received mp w/ vehicle; dose-response (fig.5); cardiovascular; peptides; animal info (male, Sprague-Dawley, 250-270g.).

P8130 Hauck,L., Harms,C., Grothe,D., An,J.F., Gertz,K., Kronenberg,G., Dietz,R., Endres,M., von Harsdorf,R. Critical role for FoxO3a-dependent regulation of p21CIP1/WAF1 in response to statin signaling in cardiac myocytes. Circulation Research 2007; 100(-1-):50-60. >>> Angiotensin II; SC; Mice; 2002; 14 days; Controls received mp w/ saline; cardiovascular; peptides; animal info (male, C57BL/6 wt or p21-/-, 5-8 wks old, 18-22g.).

P8125 Li,H.W., Gao,Y.X., Grobe,J.L., Raizada,M.K., Katovich,M.J., Sumners,C. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-2-):H727-H735. >>> Angiotensin II; SC; Rat; 2004; 4 weeks; Cardiovascular; peptides; animal info (male, Sprague-Dawley, 390-430g., 175-200g.).

P8114 Foeldes,G., Vajda,S., Lako-Futo,Z., Sarman,B., Skoumal,R., Ilves,M., deChatel,R., Karadi,I., Toth,M., Ruskoaho,H., Lepran,I. Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type. Journal of Lipid Research 2006; 47(-6-):1219-1226. >>> Angiotensin II; SC; Rat; 1003D; 24 hours; Controls received mp w/ vehicle; no stress (see p.1221); caradiovascular; peptides; animal info (male, Sprague-Dawley, 390-430g.).

P8106 Liu,D.M., Gao,L., Roy,S.K., Cornish,K.G., Zucker,I.H. Neuronal angiotensin II type 1 receptor upregulation in heart failure - Activation of activator protein 1 and jun N-terminal kinase. Circulation Research 2006; 99(-9-):1004-1011. >>> Angiotensin II; losartan; CSF, artificial; CSF/CNS; Rabbit; 2001; 6 days; Controls received no treatment; cardiovascular; peptides; animal info (male, New Zealand White, 3.2-4.1 kg., CHF).

P8104 Lu,H.Z., Fedak,P.W.M., Dai,X.J., Du,C.Q., Zhou,Y.Q., Henkelman,M., Mongroo,P.S., Lau,A., Yamabi,H., Hinek,A., Husain,M., Hannigan,G., Coles,J.G. Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation 2006; 114(-21-):2271-2279. >>> Angiotensin II; Saline; SC; Mice (transgenic); 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Tg ILK (R211A) or nonTg, 25g.).

P8090 Gao,D.F., Niu,X.L., Hao,G.H., Peng,N., Wei,J., Ning,N., Wang,N.P. Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells - Role of PPAR-gamma in vascular fibrosis. Biochemical Pharmacology 2007; 73(-2-):185-197. >>> Angiotensin II; Saline; SC; Rat; 2001; 3, 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley, 200-220g.).

P8087 Lefebvre,F., Prefontaine,A., Calderone,A., Caron,A., Jasmin,J.F., Villeneuve,L., Dupuis,J. Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure. Clinical Science 2006; 111(-3-):217-224. >>> Angiotensin II; IV (jugular); Rat; 28 days; Controls received sham surgery; functionality of mp verified by plasma Ang II levels; cardiovascular; peptides; animal info (male, Wistar, coronary artery ligation MI, 350-380g).

P8070 Morikawa-Futamatsu,K., Adachi,S., Maejima,Y., Tamamori-Adachi,M., Suzuki,J., Kitajima,S., Ito,H., Isobe,M. HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1. LIFE SCIENCES 2006; 79(-14-):1380-1390. >>> Angiotensin II; Saline; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Wistar, 8-11 wks old, 250-300g.).

P8061 Wolf,G., Bohlender,J., Bondeva,T., Roger,T., Thaiss,F., Wenzell,U.O. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. Journal of the American Society of Nephrology 2006; 17(-6-):1585-1593. >>> Angiotensin II; norepinephrine; IP; Rat; 2002; 7 days; Controls received mp w/ PBS; peptides; animal info (male, Wistar, 200g.); nephrology.

P8060 Wang,M.Y., Zhang,J., Spinetti,G., Jiang,L.Q., Monticone,R., Zhao,D., Cheng,L., Krawczyk,M., Talan,M., Pintus,G., Lakatta,E.G. Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats. American Journal of Pathology 2005; 167(-5-):1429-1442. >>> Angiotensin II; phenylephrine hydrochloride; SC; Rat; 2004; 28 days; Controls received mp w/ saline; dose-response (fig 1); cardiovascular; peptides; animal info (male, Fisher 344 x Brown Norway, 8 or 30 months old).

P8057 Eagleton,M.J., Ballard,N., Lynch,E., Srivastava,S.D., Upchurch,GR Jr, Stanley,J.C. Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation. Journal of Surgical Research 2006; 135(-2-):345-351. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 2004; 7, 14, 21, 28 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (c57BL/6J wt or ApoE -/-, male, 8-6 months old).

P8046 Taguchi,K., Kobayashi,T., Hayashi,Y., Matsumoto,T., Kamata,K. Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta. European Journal of Pharmacology 2007; 556(-1-3-):121-128. >>> Angiotensin II; Saline; Rat; 2ML2; 1 week; Plasma levels and blood pressure measured; cardiovascular; peptides; animal info (diabetic, male, Wistar, 8 weeks old, 200-230 grams); diabetes.

P8026 Oestreicher,E.M., Guo,C., Seely,E.W., Kikuchi,T., Martinez-Vasquez,D., Jonasson,L., Yao,T., Burr,D., Mayoral,S., Roubsanthisuk,W., Ricchiuti,V., Adler,G.K. Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Kidney International 2006; 70(-10-):1759-1768. >>> Angiotensin II; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides; animal info (female, Wistar, OVX, 10 weeks old).

P8022 Nakayama,H., Wilkin,B.J., Bodi,I., Molkentin,J.D. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB Journal 2006; 20(-10-):1660-1670. >>> Phenylephrine; isoproterenol; angiotensin II; PBS; SC; Mice; 2002; 2 weeks; Controls received mp w/ vehicle; cardiovascular.

P8007 Tanabe,Y., Morikawa,Y., Kato,T., Kanai,S., Watakabe,T., Nishijima,A., Iwata,H., Isobe,K., Ishizaki,M., Nakayama,K. Effects of olmesartan, an AT1 receptor antagonist, on hypoxia-induced activation of ERK1/2 and pro-inflammatory signals in the mouse lung. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2006; 374(-3-):235-248. >>> Olmesartan; angiotensin II; PBS; SC; Mice; 2001; 2004; 3 weeks; Cardiovascular; peptides; angiotensin II delivered with the 2001 pump.

P8005 Thomas,M., Gavrila,D., McCormick,M.L., Miller,FJ Jr, Daugherty,A., Cassis,L.A., Dellsperger,K.C., Weintraub,N.L. Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation 2006; 114(-5-):404-413. >>> Angiotensin II; Saline; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides.

P8000 Turban,S., Beutler,T., Morris,R.G., Masilamani,S., Fenton,R.A., Knepper,M.A., Packer,R.K. Long-term regulation of proximal tubule acid-base transporter abundance by angiotensin II. Kidney International 2006; 70(-4-):660-668. >>> Candesartan; angiotensin II; lisinopril; Saline; SC; Rat; 3 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley, 224-250 grams).

P7998 Usui,S., Yao,A., Hatano,M., Kohmoto,O., Takahashi,T., Nagai,R., Kinugawa,K.I. Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension. CIRCULATION JOURNAL 2006; 70(-9-):1208-1215. >>> Angiotensin II; isoproterenol; SC; Rat; 2ML4; 8 weeks; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides; animal info (male, Wistar, 12 weeks old, 260-300 grams).

P7990 Vongpatanasin,W., Thomas,G.D., Schwartz,R., Cassis,L.A., Osborne-Lawrence,S., Hahner,L., Gibson,L.L., Black,S., Samols,D., Shaul,P.W. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation 2007; 115(-8-):1020-1028. >>> Angiotensin II; norepinephrine; SC; Mice; 2002; 14 days; Blood pressure taken; cardiovascular; peptides; animal info (CF1-CRP).

P7984 Widder,J.D., Guzik,T.J., Mueller,C.F.H., Clempus,R.E., Schmidt,H.H.H.W., Dikalov,S.I., Griendling,K.K., Jones,D.P., Harrison,D.G. Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007; 27(-4-):762-768. >>> Angiotensin II; SC; Mice; 2002; 2 weeks; Blood pressure taken; cardiovascular; peptides; animal info (male, 12 weeks old, 25 grams).

P7982 Zhang,M.Z., Yao,B., Cheng,H.F., Wang,S.W., Inagami,T., Harris,R.C. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT1 and AT2 receptors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-43-):16045-16050. >>> Angiotensin II; bumetanide; Ethanol; SC; Rat; 6 days; Cardiovascular; peptides; animal info (male, Sprague-Dawley, 150-200 grams); bumetanide is an NKCC2 inhibitor.

P7981 Zhou,X.Y., Davis,D.R., Sigmund,C.D. The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. Journal of Biological Chemistry 2006; 281(-46-):35296-35304. >>> Angiotensin II; Saline; SC; Mice (transgenic); 1007D; 5 days; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides.

P7980 Zhou,C.C., Ahmad,S., Mi,T.J., Xia,L.W., Abbasi,S., Hewett,P.W., Sun,C.X., Ahmed,A., Kellems,R.E., Xia,Y. Angiotensin II induces soluble fms-like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circulation Research 2007; 100(-1-):88-95. >>> Angiotensin II; Saline; SC; Mice (pregnant); 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (C57BL/6J, 18-22 grams, female).

P7920 Satoh,M., Ogita,H., Takeshita,K., Mukai,Y., Kwiatkowskit,D.J., Liao,J.K. Requirement of Rac1 in the development of cardiac hypertrophy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-19-):7432-7437. >>> Angiotensin II; Saline; SC; Mice; 2004; 2 weeks; Controls received mp w/ vehicle; cardiovascular; animal info (C57BL/6, male, 11-13 weeks old).

P7910 Pillai,J.B., Gupta,M., Rajamohan,S.B., Lang,R., Raman,J., Gupta,M.P. Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. American Journal of Physiology-Heart and Circulatory Physiology 2006; 291(-4-):H1545-H1553. >>> Angiotensin II; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (C57BL/6, 8 wk old).

P7862 Ran,J.M., Hirano,T., Fukui,T., Saito,K., Kageyama,H., Okada,K., Adachi,M. Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance. METABOLISM-CLINICAL AND EXPERIMENTAL 2006; 55(-4-):478-488. >>> Angiotensin II, human; PD123319; CGP42112A; Saline; SC; Rat; 1007D; 2ML1; 2ML2; 7, 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma angiotensin II levels; dose-response (table 1); no stress (see pg. 482); peptides; multiple pumps per animal (2); animal info (male, Wistar, 8 wk. old, 400g.).

P7819 da Cunha,V., Martin-McNulty,B., Vincelette,J., Zhang,L.N., Rutledge,J.C., Wilson,D.W., Vergona,R., Sullivan,M.E., Wang,Y.X. Interaction between mild hypercholesterolemia, HDL-cholesterol levels, and angiotensin II in intimal hyperplasia in mice. Journal of Lipid Research 2006; 47(-3-):476-483. >>> Angiotensin II; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, C57BL/6, 6 months old, left carotid artery ligation).

P7745 Song,K., Backs,J., McAnally,J., Qi,X., Gerard,R.D., Richardson,J.A., Hill,J.A., Bassel-Duby,R., Olson,E.N. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Cell 2006; 125(-3-):453-466. >>> Angiotensin II; isoproterenol; Saline; SC; Mice; 2001; 7,14 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (8 wk. old (AngII), 16 wk. old (iso), CAMTA2 -/-).

P7739 Saito,K., Ishizaka,N., Aizawa,T., Sata,M., Iso-o,N, Noiri,E., Mori,I., Ohno,M., Nagai,R. Iron chelation and a free radical scavenger suppress angiotensin II- induced upregulation of TGF-beta 1 in the heart. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-4-):H1836-H1843. >>> Angiotensin II, val 5-; norepinephrine; SC; Rat; 7 days; Controls received no treatment; cardiovascular; animal info (male, Sprague-Dawley).

P7737 Shimokawa,Y., Hirata,K., Ishida,T., Kojima,Y., Inoue,N., Quertermous,T., Yokoyama,M. Increased expression of endothelial lipase in rat models of hypertension. Cardiovascular Research 2005; 66(-3-):594-600. >>> Angiotensin II; SC; Rat; 2 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley, 7 wk. old, Wistar-Kyoto, SHR-SP (30wk. old)).

P7734 Pech,V., Sikka,S.C., Sindhu,R.K., Vaziri,N.D., Majid,D.S.A. Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets. American Journal of Hypertension 2006; 19(-5-):534-540. >>> Angiotensin II; SC; Rat; 2002; 14 days; Functionality of mp verified by mean arterial pressure; cardiovascular; peptides; animal info (Sprague-Dawley, male 225-325g.).

P7733 Kimura,S., Zhang,G.X., Nishiyama,A., Shokoji,T., Yao,L., Fan,Y.Y., Rahman,M., Abe,Y. Mitochondria-derived reactive oxygen species and vascular MAP kinases - Comparison of angiotensin II and diazoxide. Hypertension 2005; 45(-3-):438-444. >>> Angiotensin II; Rat; 14 days; Controls received sham operation; functionality of mp verified by mean blood pressure; comparison of acute infusion vs. mp; cardiovascular; peptides; animal info (male, Sprague-Dawley, 10 wk old).

P7730 King,V.L., Trivedi,D.B., Gitlin,J.M., Loftin,C.D. Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2006; 26(-5-):1137-1143. >>> Angiotensin II; Saline; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, C57BL/6J, apoE -/-, 8-10 wk old).

P7729 Duka,A., Schwartz,F., Duka,I., Johns,C., Melista,E., Gavras,I., Gavras,H. A novel gene (Cmya3) induced in the heart by angiotensin II-dependent but not salt-dependent hypertension in mice. American Journal of Hypertension 2006; 19(-3-):275-281. >>> Angiotensin II; Saline; SC; Mice; 2001; 7,14 days; Controls received mp w/ saline; functionality of mp verified by systolic blood pressure; comparison of acute IV infusion vs. mp; cardiovascular; peptides; animal info (male, C57BL/6J, 8-10 wk. old).

P7677 Ivanov,A., Gerzanich,V., Ivanova,S., DenHaese,R., Tsymbalyuk,O., Simard,J.M. Adenylate cyclase 5 and Kca1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 570(-1-):73-84. >>> Epidermal growth factor; AG-1478; angiotensin II; iberiotoxin; CSF, artificial; saline; CSF/CNS (intrathecal, cisterna magna); SC; Rat; 2001; 2004; 1,3 days; 4 weeks; Controls received mp w/ aCSF; cardiovascular; peptides; animal info (female, wistar, 275-325 g); angiotensin II disolved in saline and was subcutaneously delivered for 4 weeks using the 2004 model pump; AG-1478 is an EGFR inhibitor.

P7656 Jaimes,E.A., Tian,R.X., Pearse,D., Raij,L. Up-regulation of glomerular COX-2 by angiotensin II: Role of reactive oxygen species. Kidney International 2005; 68(-5-):2143-2153. >>> Angiotensin II; SC; Rat; 1007D; 5 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley 6 wk. old).

P7646 Hirano,T., Ran,J.M., Adachi,M. Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats. Journal of Hypertension 2006; 24(-1-):103-108. >>> Angiotensin II; PD123319; CGP42112A; Saline; SC; Rat; 1007D; 2ML1; 2ML2; 2 weeks; 7 days; Controls received mp w/ vehicle; no stress (see pg.105); cardiovascular; peptides; multiple pumps per animal (2); animal info (male, Wistar, 8 wk old, 400 g); Ang II plasma levels taken.

P7645 Zhai,P.Y., Yamamoto,M., Galeotti,J., Liu,J., Masurekar,M., Thaisz,J., Irie,K., Holle,E., Yu,X.Z., Kupershmidt,S., Roden,D.M., Wagner,T., Yatani,A., Vatner,D.E., Vatner,S.F., Sadoshima,J. Cardiac-specific overexpression of AT1 receptor mutant lacking Galphaq/Galphai coupling causes hypertrophy and bradycardia in transgenic mice. Journal of Clinical Investigation 2005; 115(-11-):3045-3056. >>> Angiotensin II; Saline; Mice; mice (transgenic); 2002; 14 days; Controls received mp w/ vehicle; comparison of acute IV injection vs. mp; peptides.

P7643 Wang,D., Chabrashvili,T., Borrego,L., Aslam,S., Umans,J.G. Angiotensin II infusion alters vascular function in mouse resistance vessels: Roles of O2 BULL - and endothelium. JOURNAL OF VASCULAR RESEARCH 2006; 43(-1-):109-119. >>> Angiotensin II; Saline; SC; Mice; 1002; 12-14 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (C57BL/6, male, 20-25 g).

P7639 Zhou,M.S., Jaimes,E.A., Raij,L. Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension. Journal of Hypertension 2005; 23(-9-):1737-1743. >>> Angiotensin II; Saline; SC; Rat; 1007D; 5 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley 250-300 g).

P7637 Ruperez,M., Sanchez-Lopez,E., Blanco-Colio,L.M., Esteban,V., Rodriguez-Vita,J., Plaza,J.J., Egido,J., Ruiz-Ortega,M. The Rho-kinase pathway regulates angiotensin II-induced renal damage. Kidney International 2005; 68(--):39-45. >>> Angiotensin II; Saline; SC; Rat; 3 days; Controls received mp w/ vehicle; peptides; animal info (female, Wistar).

P7636 Amann,K., Faulhaber,J., Campean,V., Balajew,V., Dono,R., Mall,G., Ehmke,H. Impaired myocardial capillarogenesis and increased adaptive capillary growth in FGF2-deficient mice. LABORATORY INVESTIGATION 2006; 86(-1-):45-53. >>> Angiotensin II; Mice; 1007D; 6 days; Blood pressure taken; cardiovascular; peptides; animal info (C57BL/6).

P7617 Peng,X., Kraus,M.S., Wei,H.J., Shen,T.L., Pariaut,R., Alcaraz,A., Ji,G.J., Cheng,L.H., Yang,Q.L., Kotlikoff,M.I., Chen,J., Chien,K., Gu,H., Guan,J.L. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. Journal of Clinical Investigation 2006; 116(-1-):217-227. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (CFKO or WT, 1-12 wk old).

P7599 Ishizaka,N., Saito,K., Mori,I., Matsuzaki,G., Ohno,M., Nagai,R. Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II - Infused rats. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-11-):2282-2288. >>> Angiotensin II, val 5-; norepinephrine; SC; Rat; 2001; 4 weeks; 7 days; Controls received no treatment; dose-response (fig. 1); cardiovascular; peptides; animal info (male, Sprague-Dawley).

P7598 Rikitake,Y., Oyama,N., Wang,C.Y.C., Noma,K., Satoh,M., Kim,H.H., Liao,J.K. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1(+/-) haploinsufficient mice. Circulation 2005; 112(-19-):2959-2965. >>> Angiotensin II; Saline; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; no stress (see pg.2961); cardiovascular; peptides; animal info (C57BL/6J, male, 8-12 weeks); echocardiology.

P7597 De Ciuceis,C., Amiri,F., Brassard,P., Endemann,D.H., Touyz,R.M., Schiffrin,E.L. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice - Evidence for a role in inflammation in angiotensin-induced vascular injury. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-10-):2106-2113. >>> Angiotensin II, I6 5-; Saline; SC; Mice (transgenic); 14 days; Controls received mp w/ vehicle or no treatment; functionality of mp verified by systolic blood pressure; no stress (see pg.2108); cardiovascular; peptides; animal info (12-16 weeks old); DSI radiotelemetry devices implanted..

P7586 Hattori,Y., Akimoto,K., Nishikimi,T., Matsuoka,H., Kasai,K. Activation of AMP-activated protein kinase enhances angiotensin II-induced proliferation in cardiac fibroblasts. Hypertension 2006; 47(-2-):265-270. >>> Angiotensin II; Water, distilled; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague-Dawley 7 wk old).

P7583 Chen,Y., Currie,R.W. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. INFLAMMATION RESEARCH 2005; 54(-8-):338-343. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (jugular); Rat; 2001; 2ML2; 3, 7 days; Controls received mp w/ vehicle or sham HS surgery; cardiovascular; peptides; animal info (male, Sprague-Dawley 280-310 g).

P7554 Lautrette,A., Li,S.Q., Alili,R., Sunnarborg,S.W., Burtin,M., Lee,D.C., Friedlander,G., Terzi,F. Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nature Medicine 2005; 11(-8-):867-874. >>> Angiotensin II; Saline; SC; Mice; mice (transgenic); 2004; 2 months; 7 days; Controls received mp w/ vehicle; replacement therapy (nephrectomy); long-term study; pumps replaced at 1 month; peptides; animal info (C57Bl6, female, 1 week old).

P7550 Ma,Y.W., Zhang,L.P., Peng,T., Cheng,J.Z., Taneja,S., Zhang,J.Q., Delafontaine,P., Du,J. Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: Role of nuclear factor-kappaB. Endocrinology 2006; 147(-3-):1256-1263. >>> Angiotensin II; Ringer's solution; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 3 months old); endocrinology.

P7546 Ding,B., Abe,J., Wei,H., Xu,H.D., Che,W.Y., Aizawa,T., Liu,W.M., Molina,C.A., Sadoshima,J., Blaxall,B.C., Berk,B.C., Yan,C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005; 102(-41-):14771-14776. >>> Angiotensin II; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by systolic and diastolic blood pressure; no stress (see pg. 14772); cardiovascular; peptides; animal info (Sprague-Dawley).

P7530 Saito,K., Ishizaka,N., Hara,M., Matsuzaki,G., Sata,M., Mori,I., Ohno,M., Nagai,R. Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II. Hypertension 2005; 46(-5-):1180-1185. >>> Angiotensin II, val 5 -; norepinephrine; SC; Rat; 2001; 7 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 250-300 g); lipotoxicity.

P7491 Kopkan,L., Castillo,A., Navar,L.G., Majid,D.S.A. Enhanced superoxide generation modulates renal function in ANG II- induced hypertensive rats. American Journal of Physiology-Renal Physiology 2006; 290(-1-):F80-F86. >>> Angiotensin II; SC; Rat; 2002; 2 weeks; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 220-250 grams).

P7489 Lee,D.L., Sturgis,L.C., Labazi,H., Osborne,JB Jr, Fleming,C., Pollock,J.S., Manhiani,M., Imig,J.D., Brands,M.W. Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. American Journal of Physiology-Heart and Circulatory Physiology 2006; 290(-3-):H935-H940. >>> Angiotensin II; SC; Mice; 2 weeks; Controls received mp w/ saline or no treatment; functionality of mp verified by mean arterial pressure; cardiavascular; peptides; animal info (male, C57BL6 and IL-6 knockout).

P7486 Peng,H.M., Carretero,O.A., Vuljaj,N., Liao,T.D., Motivala,A., Peterson,E.L., Rhaleb,N.E. Angiotensin-converting enzyme inhibitors - A new mechanism of action. Circulation 2005; 112(-16-):2436-2445. >>> Angiotensin II; Ac-SDKP; Saline; acetic acid; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure, Ac-SDKP urine levels; cardiovascular; peptides; animal info (male, Sprague-Dawley, 200-255 grams).

P7482 Gao,L., Wang,W., Li,Y.L., Schultz,H.D., Liu,D.M., Cornish,K.G., Zucker,I.H. Simvastatin therapy normalizes sympathetic neural control in experimental heart failure roles of angiotensin II type 1 receptors and NAD(P)H oxidase. Circulation 2005; 112(-12-):1763-1770. >>> Angiotensin II; CSF, artificial; CSF/CNS; Rabbit; 2001; 7 days; Cardiovascular; peptides; animal info (male, New Zealand White, 3.2-4.1 kg); chronic heart failure.

P7474 Petcu,M., Ongali,B., El Midaoui,A., De Champlain,J., Couture,R. Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats. Peptides 2005; 26(-8-):1331-1338. >>> Angiotensin II; SC; Rat; 2002; 2 weeks; Controls received no treatment; functionality verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 230-260 g).

P7463 Matsuno,K., Yamada,H., Iwata,K., Jin,D., Katsuyama,M., Matsuki,M., Takai,S., Yamanishi,K., Miyazaki,M., Matsubara,H., Yabe-Nishimura,C. Nox1 is involved in angiotensin II-mediated hypertension - A study in Nox1-deficient mice. Circulation 2005; 112(-17-):2677-2685. >>> Angiotensin II, val 5; PBS; SC; Mice; 2002; 2004; 7, 14, 28 days; Functionality of mp verified by blood pressure; dose-response (fig. 5); cardiovascular; peptides; animal info (C5 7BL/6, Nox1 -/Y, 8-12 weeks old).

P7440 Ayabe,N., Babaev,V.R., Tang,Y.W., Tanizawa,T., Fogo,A.B., Linton,M.F., Ichikawaa,I., Fazio,S., Kon,V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis 2006; 184(-2-):312-321. >>> Angiotensin II; norepinephrine; SC; Mice; 1002; 2 weeks; Controls received mp w/ saline; dose-response (fig.1); stress/adverse reaction: (see pg. 313) 2 animals of 105 had mp extrusion; cardiovascular; peptides; animal info (female, C57BL/6, 8 weeks old).

P7438 Arimoto,T., Takeishi,Y., Takahashi,H., Shishido,T., Niizeki,T., Koyama,Y., Shiga,R., Nozaki,N., Nakajima,O., Nishimaru,K., Abe,J., Walsh,R.A., Goto,K., Kubota,I. Cardiac-specific overexpression of diacylglycerol kinase xi prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Circulation 2006; 113(-1-):60-66. >>> Angiotensin II; phenylephrine; Saline; SC; Mice (transgenic); 3,14 days; Controls received mp w/ vehicle; no stress (see pg. 63); cardiovascular; peptides.

P7422 Somogyi,A., Ruzicska,T., Blazovics,A., Ver,A., Rosta,K., Toth,M. Insulin treatment decreases the antioxidant defense mechanism in experimental diabetes. MEDICAL SCIENCE MONITOR 2005; 11(-7-):BR206-BR211. >>> Angiotensin II; SC; Rat; 2001; 22 days; Controls received mp w/ citrate buffer; cardiovascular; peptides; animal info (male, wistar, 5 weeks old, 100-130 g).

P7404 Bouzeghrane,F., Reinhardt,D.P., Reudelhuber,T.L., Thibault,G. Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosis. American Journal of Physiology-Heart and Circulatory Physiology 2005; 289(-3-):H982-H991. >>> Angiotensin II; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides; animal info (male, Sprague-Dawley).

P7399 Candido,R., Carraro,M., Fior,F., Artero,M.L., Zennaro,C., Burrell,L.M., Davis,B.J., Cattin,M.R., Bardelli,M., Faccini,L., Carretta,R., Fabris,B. Glomerular permeability defect in hypertension is dependent on renin angiotensin system activation. American Journal of Hypertension 2005; 18(-6-):844-850. >>> Angiotensin II; Saline; SC; Rat; 2002; ; Bloodpressure taken; cardiovascular; peptides; animal info (male, wistar, 6-7 weeks old).

P7391 Martin-McNulty,B., Vincelette,J., Vergona,R., Sullivan,M.E., Wang,Y.X. Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system. ULTRASOUND IN MEDICINE AND BIOLOGY 2005; 31(-6-):745-749. >>> Angiotensin II; SC; Mice (knockout); 2004; 28 days; Cardiovascular; peptides; animal info (male).

P7390 Kim-Mitsuyama,S., Yamamoto,E., Tanaka,T., Zhan,Y., Izumi,Y., Izumiya,Y., Ioroi,T., Wanibuchi,H., Iwao,H. Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats. Stroke 2005; 36(-5-):1077-1082. >>> Angiotensin II; Rat; 2 weeks; Blood pressure taken; cardiovascular; peptides; ischemia (cerebral); animal info (male, 11 weeks old).

P7371 Xue,B.J., Pamidimukkala,J., Hay,M. Sex differences in the development of angiotensin II-induced hypertension in conscious mice. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-5-):H2177-H2184. >>> Angiotensin II; SC; Mice; 1002; 7 days; Functionality of mp verified by blood pressure taken; cardiovascular; peptides; telemetry implants used.

P7348 Song,Y.H., Li,Y.X., Du,J., Mitch,W.E., Rosenthal,N., Delafontaine,P. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. Journal of Clinical Investigation 2005; 115(-2-):451-458. >>> Angiotensin II; SC; Mice; 1007D; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by blood pressure response; cardiovascular; peptides.

P7341 Zhou,Y., Chen,R., Catanzaro,S.E., Hu,L.F., Dansky,H.M., Catanzaro,D.F. Differential effects of angiotensin II on atherogenesis at the aortic sinus and descending aorta of apolipoprotein-E-deficient mice. American Journal of Hypertension 2005; 18(-4-):486-492. >>> Angiotensin II; Saline; SC; Mice (knockout); 2004; 8-32 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 4 weeks; cardiovascular; peptides.

P7338 Tsuruda,T., Kato,J., Hatakeyama,K., Masuyama,H., Cao,Y.N., Imamura,T., Kitamura,K., Asada,Y., Eto,T. Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats. Cardiovascular Research 2005; 65(-4-):921-929. >>> Angiotensin II; adrenomedullin; Saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); agents in separate pumps.

P7327 Keys,J.R., Zhou,R.H., Harris,D.M., Druckman,C.A., Eckhart,A.D. Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Circulation 2005; 112(-8-):1145-1153. >>> CGP20712A; ICI 118,551; angiotensin II; PBS; SC; Mice (transgenic); 7 days; Controls received mp w/ vehicle; cardiovascular; antihypertensive; B-adrenergic receptor antagonists.

P7325 Akishita,M., Nagai,K., Xi,H., Yu,W., Sudoh,N., Watanabe,T., Ohara-Imaizumi,M., Nagamatsu,S., Kozaki,K., Horiuchi,M., Toba,K. Renin-angiotensin system modulates oxidative stress-induced endothelial cell apoptosis in rats. Hypertension 2005; 45(-6-):1188-1193. >>> Angiotensin II; SC; Rat; 1003D; 3 days; Controls received mp w/ vehicle; dose-response; cardiovascular; peptides.

P7324 Bataller,R., Gaebele,E., Parsons,C.J., Morris,T., Yang,L., Schoonhoven,R., Brenner,D.A., Rippe,R.A. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology 2005; 41(-5-):1046-1055. >>> Angiotensin II; SC; Rat; 2002; 2ML2; 2 weeks; Controls received mp w/ saline and sham-BDL; functionality of mp verified by residual volume; no stress (see pg. 1048); cardiovascular; peptides; "Ang II infusion (25 ng/kg/min) was not associated with mortality and was well tolerated." (p. 1048).

P7323 Budzyn,K., Marley,P.D., Sobey,C.G. Opposing roles of endothelial and smooth muscle phosphatidylinositol 3- kinase in vasoconstriction: Effects of rho-kinase and hypertension. Journal of Pharmacology and Experimental Therapeutics 2005; 313(-3-):1248-1253. >>> Angiotensin II; water, sterile; SC; Rat; 2001; 14 days; Controls received mp w/ vehicle; functionality of mp verified by mean arterial pressure; cardiovascular; peptides.

P7310 Wang,Y.X., Martin-McNulty,B., da Cunha,V., Vincelette,J., Lu,X.G., Feng,Q.P., Halks-Miller,M., Mahmoudi,M., Schroeder,M., Subramanyam,B., Tseng,J.L., Deng,G.D., Schirm,S., Johns,A., Kauser,K., Dole,W.P., Light,D.R. Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation 2005; 111(-17-):2219-2226. >>> Angiotensin II; PBS; SC; Mice (knockout); 2004; 1 month; Controls received mp w/ vehicle; cardiovascular; peptides.

P7305 Wang,Y.X., da Cunha,V., Martin-McNulty,B., Vincelette,J., Li,W.W., Choy,D.F., Halks-Miller,M., Mahmoudi,M., Schroeder,M., Johns,A., Light,D.R., Dole,W.P. Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. European Journal of Pharmacology 2005; 512(-2-3-):215-222. >>> Angiotensin II; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides.

P7298 Barrett,C.J., Guild,S.J., Ramchandra,R., Malpas,S.C. Baroreceptor denervation prevents sympathoinhibition during angiotensin II-induced hypertension. Hypertension 2005; 46(-1-):168-172. >>> Angiotensin II; IV (jugular); Rabbit; 2ML1; 1 week; Cardiovascular; peptides; radiotelemetry transmitter IA.

P7290 Hattori,Y., Akimoto,K., Gross,S.S., Hattori,S., Kasai,K. Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats. Diabetologia 2005; 48(-6-):1066-1074. >>> Angiotensin II; Water, distilled; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides.

P7284 Brassard,P., Amiri,F., Schiffrin,E.L. Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries. Hypertension 2005; 46(-3-):598-606. >>> Angiotensin II, Ile5-; angiotensin II, Sar1-Ile8-; SC; Rat; 7 days; Functionality of mp verified by systolic blood pressure; cardiovascular; peptides; AT1/AT2 antagonist.

P7282 Mousa,T.M., Gao,L., Cornish,K.G., Zucker,I.H. Effects of angiotensin II on autonomic components of nasopharyngeal stimulation in male conscious rabbits. Journal of Applied Physiology 2005; 98(-5-):1607-1611. >>> Angiotensin II; Acetic acid; SC; Rabbit; 2ML2; 7 days; Comparison of acute icv infusion vs. mp; cardiovascular; peptides.

P7277 Kawano,S., Kubota,T., Monden,Y., Kawamura,N., Tsutsui,H., Takeshita,A., Sunagawa,K. Blockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II. Cardiovascular Research 2005; 67(-4-):689-698. >>> Angiotensin II; Saline; acetic acid; IP; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by systemic blood pressure; dose-response (fig. 2); cardiovascular; peptides; NF-KB knockout mice.

P7272 Ikeda,Y., Aihara,K., Sato,T., Akaike,M., Yoshizumi,M., Suzaki,Y., Izawa,Y., Fujimura,M., Hashizume,S., Kato,M., Yagi,S., Tamaki,T., Kawano,H., Matsumoto,T., Azuma,H., Kato,S., Matsumoto,T. Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis. Journal of Biological Chemistry 2005; 280(-33-):29661-29666. >>> Angiotensin II; Saline; SC; Mice; 1002; 2 weeks; Cardiovascular; peptides.

P7268 Kase,H., Hashikabe,Y., Uchida,K., Nakanishi,N., Hattori,Y. Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. Journal of Hypertension 2005; 23(-7-):1375-1382. >>> Angiotensin II; Water, distilled; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides.

P7255 Matsui,R., Xu,S.Q., Maitland,K.A., Hayes,A., Leopold,J.A., Handy,D.E., Loscalzo,J., Cohen,R.A. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation 2005; 112(-2-):257-263. >>> Angiotensin II; Sodium chloride; acetic acid; SC; Mice; 1007D; 6 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; no stress (see pg. 259); cardiovascular; peptides; G6PD-defecient hemizygous mutant mice.

P7237 Buergelova,M., Kramer,H.J., Teplan,V., Thumova,M., Cervenka,L. Effects of angiotensin (1-7) blockade on renal function in rats with enhanced intrarenal Ang II activity. Kidney International 2005; 67(-4-):1453-1461. >>> Angiotensin II; SC; Rat; 2002; 2 weeks; Controls received no treatment.

P7235 Freund,C., Schmidt-Ullrich,R., Baurand,A., Dunger,S., Schneider,W., Loser,P., El-Jamali,A., Dietz,R., Scheidereit,C., Bergmann,M.W. Requirement of nuclear factor-kappa B in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo. Circulation 2005; 111(-18-):2319-2325. >>> Angiotensin II; isoproterenol; Saline, physiological; acetic acid; SC; Mice (transgenic); 1002; 7, 12, 14 days; Controls received sham operation; cardiovascular; peptides.

P7230 Gletsu,N., Doan,T.N., Cole,J., Sutliff,R.L., Bernstein,K.E. Angiotensin II-induced hypertension in mice caused an increase in insulin secretion. VASCULAR PHARMACOLOGY 2005; 42(-3-):83-92. >>> Angiotensin II; Saline; SC; Mice; 2004; 2, 4 weeks; Controls received mp w/ vehicle; no stress (see pg. 84); cardiovascular; peptides.

P7229 Gao,L., Wang,W., Li,Y.L., Schultz,H.D., Liu,D.M., Cornish,K.G., Zucker,I.H. Sympathoexcitation by central ANG II: Roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-5-):H2271-H2279. >>> Angiotensin II; losartan; Saline, isotonic; CSF/CNS; Rabbit; 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; cyanoacrylate adhesive; cannula position verified by Evans blue dye.

P7225 Cassis,L.A., Helton,M.J., Howatt,D.A., King,V.L., Daugherty,A. Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. British Journal of Pharmacology 2005; 144(-3-):443-448. >>> Aldosterone; angiotensin II; Propylene glycol; saline; ethanol; water; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; replacement therapy (hyperlipidemic); no stress (see pg. 444); cardiovascular; 9% ethanol.

P7213 Pflueger,A., Croatt,A.J., Peterson,T.E., Smith,L.A., d'Uscio,L.V., Katusic,Z.S., Nath,K.A. The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II. American Journal of Physiology-Renal Physiology 2005; 288(-3-):F552-F558. >>> Angiotensin II; Ringer's solution, lactated; SC; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; no stress (see pg. F554); peptides; "The administration of ANG II was well tolerated in both the control and Gunn rats, without overt clinically adverse effects" (p. F554).

P7180 Lapante,M.A., Wu,R., Moreau,P., De Champlain,J. Endothelin mediates superoxide production in angiotensin II-induced hypertension in rats. Free Radical Biology and Medicine 2005; 38(-5-):589-596. >>> Angiotensin II; SC; Rat; 2002; 12 days; Controls received mp w/ vehicle, or no treatment; cardiovascular; peptides.

P7159 Iwasaki,T., Mukasa,K., Yoneda,M., Ito,S., Yamada,Y., Mori,Y., Fujisawa,N., Fujisawa,T., Wada,K., Sekihara,H., Nakajima,A. Marked attenuation of production of collagen type I from cardiac fibroblasts by dehydroepiandrosterone. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2005; 288(-6-):E1222-E1228. >>> Angiotensin II; dehydroepiandrosterone; SC; Rat; 2002; 2 weeks; Cardiovascular; peptides.

P7154 Zhang,L.P., Ma,Y.W., Zhang,J.Q., Cheng,J.Z., Du,J. A new cellular signaling mechanism for angiotensin II activation of NF-kappaB-An IkappaB-independent, RSK-mediated phosphorylation of p65. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-6-):1148-1153. >>> Angiotensin II; Ringer's solution; Rat; 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides.

P7152 Wesseling,S., Ishola,DA Jr, Joles,J.A., Bluyssen,H.A., Koomans,H.A., Braam,B. Resistance to oxidative stress by chronic infusion of angiotensin II in mouse kidney is not mediated by the AT2 receptor. American Journal of Physiology-Renal Physiology 2005; 288(-6-):F1191-F1200. >>> Angiotensin II; Saline; SC; Mice; 1003D; 1002; 2004; 1,9,28 days; Controls received mp w/ vehicle; functionality of mp verified by blood pressure taken; dose-response (p.F1193); cardiovascular; peptides.

P7148 Prieto-Carrasquero,M.C., Kobori,H., Ozawa,Y., Guttierrez,A., Seth,D., Navar,L.G. AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. American Journal of Physiology-Renal Physiology 2005; 289(-3-):F632-F637. >>> Angiotensin II; olmesartan; SC; Rat; 13 days; Functionality of mp verified by blood pressure taken; cardiovascular; peptides.

P7013 Welch,W.J., Blau,J., Xie,H., Chabrashvili,T., Wilcox,C.S. Angiotensin-induced defects in renal oxygenation: role of oxidative stress. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-1-):H22-H28. >>> Angiotensin II; tempol; Sodium chloride; SC; Rat; 2002; 12-13 days; Controls received mp w/ vehicle; no stress (pg. H23); cardiovascular; antihypertensive; peptides; multiple pumps per animal (2).

P7003 Vazquez,E., Coronel,I., Bautista,R., Romo,E., Villalon,C.M., vila-Casado,M.C., Soto,V., Escalante,B. Angiotensin II-dependent induction of AT2 receptor expression after renal ablation. American Journal of Physiology-Renal Physiology 2005; 288(-1-):F207-F213. >>> PD123319; angiotensin II; nifedipine; SC; Rat; 7,14 days; Controls received no agent and/or sham renal ablation; replacement theraphy (nephrectomy); antihypertensive; peptides; AT2 receptor antagonist.

P6972 Ishizaka,N., Saito,K., Noiri,E., Sata,M., Ikeda,H., Ohno,A., Ando,J., Mori,I., Ohno,M., Nagai,R. Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2005; 288(-4-):R1063-R1070. >>> Angiotensin II; SC; Rat; 2001; 7, 30 days; Blood pressure taken; peptides.

P6964 Anning,P.B., Coles,B., Bermudez-Fajardo,A., Martin,P.E.M., Levison,B.S., Hazen,S.L., Funk,C.D., Kuehn,H., O'Donnell,V.B. Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice. American Journal of Pathology 2005; 166(-3-):653-662. >>> Angiotensin II; SC; Mice (knockout); 1002; 7 days; Cardiovascular; peptides.

P6957 Beaucage,P., Iglarz,M., Servant,M., Touyz,R.M., Moreau,P. Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis. Journal of Hypertension 2005; 23(-2-):329-335. >>> Angiotensin II; endothelin; SC; Rat; 1003D; 26 hours; Cardiovascular; peptides.

P6940 Takahashi,N., Lopez,M.L.S.S., Cowhig,JE Jr, Taylor,M.A., Hatada,T., Riggs,E., Lee,G., Gomez,R.A., Kim,H.S., Smithies,O. Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. Journal of the American Society of Nephrology 2005; 16(-1-):125-132. >>> Angiotensin II; Saline; SC; Mice; 1002; ; Blood pressure and plasma levels taken; cardiovascular; peptides.

P6740 Zhang,Z., Rhinehart,K., Solis,G., Pittner,J., Lee-Kwon,W., Welch,W.J., Wilcox,C.S., Pallone,T.L. Chronic ANG II infusion increases NO generation by rat descending vasa recta. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-1-):H29-H36. >>> Angiotensin II; Water; SC; Rat; 2002; 11-13 days; Controls received mp w/ vehicle; cardiovascular; peptides.

P6389 Sadjadi,J., Kramer,G.L., Yu,C.H., Welborn,MB III, Modrall,J.G. Angiotensin II exerts positive feedback on the intrarenal renin-angiotensin system by an angiotensin converting enzyme-dependent mechanism. Journal of Surgical Research 2005; 129(-2-):272-277. >>> Angiotensin II; Saline; IP; Rat; ; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (Sprague-Dawley, 200-250 g); no pump model or duration listed.