References on the Administration of Angiotensin II Using ALZET® Osmotic Pumps

16360 Hauck, L., Grothe, D., Billia, F. p21(CIP1/WAF1)-dependent inhibition of cardiac hypertrophy in response to Angiotensin II involves Akt/Myc and pRb signaling. Peptides 2016; 83(--):38-48. >>> Angiotensin II; Saline; SC; mice; 2002; animal info (week old p21KO and wild type mice); functionality of mp verified by blood pressure; tail cuff plethysmography (pg. 44); cardiovascular; peptides; Dose (2 mg/kg/day);.

16359 Haskett, D. G., Maestas, D., Howerton, S. J., Smith, T., Ardila, D. C., Doetschman, T., Utzinger, U., McGrath, D., McIntyre, J. O., Vande Geest, J. P. 2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm. Microsc Microanal 2016; 22(-2-):349-60. >>> Angiotensin II; SC; Mice; 2002; animal info (4- to 6-month-old adult ApoE−/− mice); cardiovascular; peptide; models of aneurysm in mice; “Although previous work in our lab has found no difference between wildtype mice with and without vehicle infusion via pump implantation (Haskett et al., 2012b; Haskett et al., 2013), any further studies would need to include suchgroups to provide evidence that pump implantation does not alter MMP expression” (pg. 9)“…it is unknown when the aneurysms formed in the ApoE−/− 14-day AngII-infused mice that presented with suprarenal aneurysms, and there is the possibility that the aneurysms being compared could have developed in days or over a week apart and could be at varying stages of development” (pg.9); Dose (1000 ng/kg/min);.

16347 Gao, W., Wang, H., Zhang, L., Cao, Y., Bao, J. Z., Liu, Z. X., Wang, L. S., Yang, Q., Lu, X. Retinol-Binding Protein 4 Induces Cardiomyocyte Hypertrophy by Activating TLR4/MyD88 Pathway. Endocrinology 2016; 157(-6-):2282-93. >>> Angiotensin II; SC; Mice; 1002; animal info (C57BL/6 male mice of 6–8 weeks old); functionality of mp verified by echocardiography; cardiovascular; peptides; Dose (1 ug/kg/min);.

16345 Galan, M., Varona, S., Orriols, M., Rodriguez, J. A., Aguilo, S., Dilme, J., Camacho, M., Martinez-Gonzalez, J., Rodriguez, C. Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors. Dis Model Mech 2016; 9(-5-):541-52. >>> Angiotensin II; Saline; SC; mice; 1004; Controls received mp w/ vehicle; animal info (10-week-old male ApoE−/− mice); functionality of mp verified by blood pressure; peptides; abdominal aortic aneurysm study; Dose (1000 ng/kg/min);.

16318 Wang, Q., Zhou, T., Liu, Z., Ren, J., Phan, N., Gupta, K., Stewart, D. M., Morgan, S., Assa, C., Kent, K. C., Liu, B. Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Sci Rep 2017; 7(--):42159. >>> Angiotensin II; SC; Mice; 2004; animal info (12-week-old, apolipoprotein E–deficient mice); cardiovascular; Dose (1000 ng/kg/ min);.

16296 Burke, S. D., Zsengeller, Z. K., Khankin, E. V., Lo, A. S., Rajakumar, A., DuPont, J. J., McCurley, A., Moss, M. E., Zhang, D., Clark, C. D., Wang, A., Seely, E. W., Kang, P. M., Stillman, I. E., Jaffe, I. Z., Karumanchi, S. A. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest 2016; 126(-7-):2561-74. >>> Angiotensin II; Saline; SC; Mice (pregnant); 1002; Controls received mp w/ vehicle, or were non-pregnant; animal info (adult male, female CD-1 mice; 8-12 wks old); functionality of mp verified by blood pressure (pg. 2562); dose-response (pg. 2563); cardiovascular; antihypertensive; Study looking at preeclampsia; Dose (0.43 mg/kg/d);.

16290 Dai, H. L., Hu, W. Y., Jiang, L. H., Li, L., Gaung, X. F., Xiao, Z. C. p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice. Sci Rep 2016; 6(--):27600. >>> Angiotensin II; saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (Eight week-old C57BL/6 wild-type male mice, p38KI/+ male mice (22–26 g)); functionality of mp verified by blood pressure (pg 3); Tail-cuffplethysmography; cardiovascular; peptides; Dose (1900 ng/kg/min);.

16278 Yin, Z., Wang, X., Zhang, L., Zhou, H., Wei, L., Dong, X. Aspirin Attenuates Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting the Ca(2+)/Calcineurin-NFAT Signaling Pathway. Cardiovasc Ther 2016; 34(-1-):21-9. >>> Angiotensin II; Saline; SC; mice; 1007D; Controls received no treatment and pre-treatment with aspirin; animal info (Eight-week-old male kunming mice (23–27 g); functionality of mp verified by heart tissue samples; cardiovascular; peptides; Model of cardiac hypertrophy; Dose (1 mg/kg/day);.

16273 Wilkinson, R., Song, W., Smoktunowicz, N., Marston, S. A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress. Am J Physiol Heart Circ Physiol 2015; 309(-11-):H1936-46. >>> Angiotensin II; Saline; SC; mice; 1004; Controls received mp w/ vehicle; animal info (mice (8 wk old)); functionality of mp verified by echocardiography; dose-response (p. H1938, H1941); good methods (p. H1938); post op. care (buprenorphine); cardiovascular; 7 mm Reflex used; Dose (1.4 and 2.0 mg/kg/day);.

16272 Wang, J., Sukhova, G. K., Liu, J., Ozaki, K., Lesner, A., Libby, P., Kovanen, P. T., Shi, G. P. Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. J Vasc Surg 2015; 62(-6-):1615-24. >>> Angiotensin II; SC; mice; 2004; animal info (10-week-old Ldlr -/- Ctsg -/- mice and their littermate Ldlr -/- Ctsg +/+ control mice); functionality of mp verified by blood pressure; Dose (1000 ng/kg/min);.

16252 Sparks, M. A., Stegbauer, J., Chen, D., Gomez, J. A., Griffiths, R. C., Azad, H. A., Herrera, M., Gurley, S. B., Coffman, T. M. Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. J Am Soc Nephrol 2015; 26(-12-):2953-62. >>> Angiotensin II; SC; mice; animal info 8- to 12-week-old male SMKO and control mice ; functionality of mp verified by blood pressure via radiotelemetry; cardiovascular; Dose (400 ng/kg/min, 1000 ng/kg/min);.

16248 Shirasuna, K., Karasawa, T., Usui, F., Kobayashi, M., Komada, T., Kimura, H., Kawashima, A., Ohkuchi, A., Taniguchi, S., Takahashi, M. NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy. Endocrinology 2015; 156(-11-):4281-92. >>> Angiotensin II; Saline; SC; Mice (pregnant); 2001; Controls received mp w/ vehicle; animal info (Asc -/- pregnant mice, 8-12 weeks old); functionality of mp verified by blood pressure tail cuff; dose-response; Dose (500ng/kg/day, 1500ng/kg/day);.

16240 Qin, Z., Bagley, J., Sukhova, G., Baur, W. E., Park, H. J., Beasley, D., Libby, P., Zhang, Y., Galper, J. B. Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3. J Mol Cell Cardiol 2015; 87(--):160-70. >>> Angiotensin II; SC; mice; 2004; Controls received placebo treatment; animal info (Male ApoE−/− mice on a C57BL/6 J background); cardiovascular; peptides; Abdominal Aortic Aneurysm; Dose (750 ng/kg/min);.

16238 Aiko Sakamoto,, Yasutomi Higashikuni,, Makiko Hongo,, Yasushi Imai,, Kazuhiko Koike,, Ryozo Nagai,, Issei Komuro,, Nobukazu Ishizaka  Journal of Atherosclerosis and Thrombosis 2015; 22(-12-):1225-1234. >>> Angiotensin II (Val5); SC; rat; Controls received no treatment; animal info (male Sprague-Dawley rats, 250-300 g); dose-response (pg 1228); diabetes; Dose (0.7 mg/kg/day);.

16231 Pollow, D. P., Jr., Romero-Aleshire, M. J., Sanchez, J. N., Konhilas, J. P., Brooks, H. L. ANG II-induced hypertension in the VCD mouse model of menopause is prevented by estrogen replacement during perimenopause. Am J Physiol Regul Integr Comp Physiol 2015; 309(-12-):R1546-52. >>> Angiotensin II; SC; mice; 1004; animal info (female C57BL/6J); functionality of mp verified by tail cuff blood pressure; cardiovascular; Isoflurane used; menopause study; 17B-estradiol replacement prevents increase in mean arterial pressure; Dose (800 ng/kg/min);.

16221 Oller, J., Alfranca, A., Mendez-Barbero, N., Villahoz, S., Lozano-Vidal, N., Martin-Alonso, M., Arroyo, A. G., Escolano, A., Armesilla, A. L., Campanero, M. R., Redondo, J. M. C/EBPbeta and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol 2015; 35(-19-):3409-22. >>> Vascular Endothelial Growth Factor, Angiotensin II, Losartan, Cyclosporine; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (Calcineurin (CN) B1 (Cnb1_/fl) conditional knockout mice, C57BL/6 mice); dose-response; vegf aka vascular endothelial growth factor; Dose (VEGF 25 ug/kg/day, AngII 1 ug/kg/min, CsA 5 mg/kg/day, Losartan 10 mg/kg/day);.

16216 Nayak, S., Khan, M. A., Wan, T. C., Pei, H., Linden, J., Dwinell, M. R., Geurts, A. M., Imig, J. D., Auchampach, J. A. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Purinergic Signal 2015; 11(-4-):519-31. >>> Angiotensin II; SC; rat; 2004; Controls received mp w/ vehicle; animal info (SS-Adora2b mutant rats, aged 7–8 weeks); functionality of mp verified by blood pressure, ECG; dose-response; Isoflurane anesthesia; hypertension; Dose (200 ng/kg/min);.

16212 Miao, X. N., Siu, K. L., Cai, H. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. J Mol Cell Cardiol 2015; 87(--):152-9. >>> Angiotensin II; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (Hph-1 male mice at 6 months); functionality of mp verified by blood pressure; dose-response (pg 154); cardiovascular; cardiovascular; Aortic aneurism; hypertension; Dose ((0.7 mg/kg per day);.

16210 McNeill, E., Iqbal, A. J., White, G. E., Patel, J., Greaves, D. R., Channon, K. M. Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo. Sci Rep 2015; 5(--):17404. >>> Angiotensin II; saline; SC; mice; Controls received mp w/ vehicle; animal info (10–12 week old male C57bl/6J mice); functionality of mp verified by analyzing aortas post-mortem; dose-response (pg 8); cardiovascular; peptides; Isoflurane infusion; Dose (1 mg/kg/day);.

16255 Matsuda S,, Umemoto S,, Yoshimura K,, Itoh S,, Murata T,, Fukai T,, Matsuzaki M. AngiotensinⅡ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4. Journal of Atherosclerosis and Thrombosis 2015; 228(-8-):833-844. >>> Angiotensin II, Norepinephrine; Saline, physiological; SC; mice; 1002; Controls received mp w/ vehicle; animal info (male, 12-16 wks, WT Balb/c mice); functionality of mp verified by ECG; cardiovascular; peptides; peptides; Dose (Ang II– 1.1 mg/kg/day, Norepinephrine – 5.6 mg/kr/day);.

16185 Su, C. H., Tsai, C. Y., Chang, A. Y., Chan, J. Y., Chan, S. H. MRI/DTI of the Brain Stem Reveals Reversible and Irreversible Disruption of the Baroreflex Neural Circuits: Clinical Implications. Theranostics 2016; 6(-6-):837-48. >>> Angiotensin II; CSF/CNS (ventricle); Mice; 1007D; animal info (male, C57BL6, adult); cardiovascular; peptides; bp measured using radiotelemetry (DSI); Dose (7.5 ug/hr);.

16184 Sonkusare, S. K., Dalsgaard, T., Bonev, A. D., Nelson, M. T. Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators. J Physiol 2016; 594(-12-):3271-85. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6, 12-14 weeks old); cardiovascular; peptides; Dose (1.4 mg/kg/day);“…systolic blood pressure in the mice infused with 0.9% saline for 3 weeks was 121±5 mmHg (n = 4), and the systolic blood pressure in the mice infused with Ang II was 180±6 mmHg.” pg 3274;.

16178 Shi, Y., Liu, T., He, L., Dougherty, U., Chen, L., Adhikari, S., Alpert, L., Zhou, G., Liu, W., Wang, J., Deb, D. K., Hart, J., Liu, S. Q., Kwon, J., Pekow, J., Rubin, D. T., Zhao, Q., Bissonnette, M., Li, Y. C. Activation of the Renin-Angiotensin System Promotes Colitis Development. Sci Rep 2016; 6(--):27552. >>> Angiotensin II; Mice; Controls received mp w/ PBS; animal info (C57BL6J); cardiovascular; peptides; Dose (0.7 g/kg/day); Interesting (used RASTg mice - something to look out for“RenTg mouse line is a genetic equivalent of chronic Ang II infusion by a minipump that is a lifelong and noninvasive” pg 5);.

16165 Ren, W., Liu, Y., Wang, X., Jia, L., Piao, C., Lan, F., Du, J. beta-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep 2016; 6(--):28149. >>> Angiotensin II; SC; Mice; animal info (male, C57Bl6 or FVB, 7 weeks old); cardiovascular; peptides; Dose (1 ug/kg/min);.

16163 Ramkumar, N., Stuart, D., Mironova, E., Bugay, V., Wang, S., Abraham, N., Ichihara, A., Stockand, J. D., Kohan, D. E. Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport. Am J Physiol Renal Physiol 2016; 311(-1-):F186-94. >>> Angiotensin II; SC; Mice; 1002; animal info (PRR KO or WT, 3-4 months); cardiovascular; peptides; bp measured using radiotelemetry (DSI); see bp graph pg 4; Dose (600 ng/kg/min);.

16161 Ragot, H., Monfort, A., Baudet, M., Azibani, F., Fazal, L., Merval, R., Polidano, E., Cohen-Solal, A., Delcayre, C., Vodovar, N., Chatziantoniou, C., Samuel, J. L. Loss of Notch3 Signaling in Vascular Smooth Muscle Cells Promotes Severe Heart Failure Upon Hypertension. Hypertension 2016; 68(-2-):392-400. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, Noch3 -/- or WT, adult); cardiovascular; peptides; bp measured using tail cuff; see bp comparison chart pg 394; Dose (1 ug/kg/min);.

16156 Porpino, S. K., Zollbrecht, C., Peleli, M., Montenegro, M. F., Brandao, M. C., Athayde-Filho, P. F., Franca-Silva, M. S., Larsson, E., Lundberg, J. O., Weitzberg, E., Persson, E. G., Braga, V. A., Carlstrom, M. Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension. Br J Pharmacol 2016; 173(-14-):2290-302. >>> Angiotensin II; SC; Mice; cardiovascular; peptides; bp measured using tail cuff; Dose (400 ng/kg/min); see bp elevation pg 2296;.

16151 Pedram, A., Razandi, M., Narayanan, R., Levin, E. R. Estrogen receptor beta signals to inhibition of cardiac fibrosis. Mol Cell Endocrinol 2016; 434(--):57-68. >>> Angiotensin II; LGND2, Beta-; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (female, WT or ERB gene deleted, 12-16 weeks old, OVX); cardiovascular; peptides; B-LGND2 is a selective ERB agonist; Dose (0.7 mg/kg/day);.

16147 Orriols, M., Varona, S., Marti-Pamies, I., Galan, M., Guadall, A., Escudero, J. R., Martin-Ventura, J. L., Camacho, M., Vila, L., Martinez-Gonzalez, J., Rodriguez, C. Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics. Cardiovasc Res 2016; 110(-3-):431-42. >>> Angiotensin II; Mice; 1002; animal info (male, C57BL6J); cardiovascular; peptides; Dose (1000 ng/kg/min);.

16144 Palao, T., Rippe, C., van Veen, H., VanBavel, E., Sward, K., Bakker, E. N. Thrombospondin-4 knockout in hypertension protects small-artery endothelial function but induces aortic aneurysms. Am J Physiol Heart Circ Physiol 2016; 310(-11-):H1486-93. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (WT or TSP-4 KO, 4-6 months old); cardiovascular; peptides; bp measured using tail cuff; Dose (700 ug/kg/day);.

16135 Hayano, S., Takefuji, M., Maeda, K., Noda, T., Ichimiya, H., Kobayashi, K., Enomoto, A., Asai, N., Takahashi, M., Murohara, T. Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction. J Mol Cell Cardiol 2015; 88(--):55-63. >>> Angiotensin II; Saline; SC; mice; 1007D; Controls received mp w/ vehicle; animal info: Girdin-deficient mice (Girdin−/− mice), Girdin S1416A knock-in mice (GirdinSA/SA mice); cardiovascular; peptides; “These results suggest that phosphorylation at serine 1416 might be involved in cardiac disease pathogenesis.” (pg. 57); Dose: 1000 ng/kg/min.

16134 Guanghua Hao,, Zhenhua Han,, Zhe Meng,, Jin Wei,, Dengfeng Gao,, Hong Zhang,, Nanping Wang  INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2015; 8(-9-):10216-10227. >>> Angiotensin II; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info: Male Sprague-Dawley rats (180±1.6 g); functionality of mp verified by systolic blood pressure; dose-response (pg 10219); cardiovascular; peptides; Overall study looks at cardiac fibrosis; Dose: 150 ng/kg/min.

16130 Gopal, K., Gowtham, M., Sachin, S., Ravishankar Ram, M., Shankar, E. M., Kamarul, T. Attrition of Hepatic Damage Inflicted by Angiotensin II with alpha-Tocopherol and beta-Carotene in Experimental Apolipoprotein E Knock-out Mice. Sci Rep 2015; 5(--):18300. >>> Angiotensin II; Saline; SC; mice; Controls received mp w/ vehicle; animal info: Apoe−/− mice; long-term study; peptides; found that liver damage was induced by Ang II; Dose: 1.44 mg/kg/day; 50Ǩg/30 gm.

16123 Gerardo Garc´•a-Rivas,, Keith A. Youker,, Carlos Orrego,, Jos´e Flores-Arredondo,, Carlos E. Guerrero-Beltr´an,, Andrea Cordero-Reyes,, Janet A. Guti´errez-Uribe,, Marisol Garc´•a,, Sergio O. Serna-Saldivard, Guillermo Torre-Amione  RSC Adv 2015; 5(--):90858-90865. >>> Angiotensin II; SC; mice; 1004; animal info: Twelve week-old male C57BL/6 mice; Non-ischemic cardiomyopathy mice model; functionality of mp verified by CODA noninvasive tail cuff blood monitoring system; cardiovascular; Dose: 0.7 mg per kg per day.

16122 Fry, J. L., Shiraishi, Y., Turcotte, R., Yu, X., Gao, Y. Z., Akiki, R., Bachschmid, M., Zhang, Y., Morgan, K. G., Cohen, R. A., Seta, F. Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc 2015; 4(-9-):e002384. >>> Angiotensin II; Norepinephrine; Saline; Ascorbate; SC; mice; 1007D; 1002; animal info: WT, SMKO, and SMTg mice aged 8 weeks (C57Bl/6J genetic background); functionality of mp verified by radiotelemetry; 1 mmol/L ascorbate; cardiovascular; antihypertensive, norepinephrine; Dose: 1 mg/kg per day of AngII; 10 mg/kg per day of norepinephrine.

16118 Fabbiano, S., Menacho-Marquez, M., Robles-Valero, J., Pericacho, M., Matesanz-Marin, A., Garcia-Macias, C., Sevilla, M. A., Montero, M. J., Alarcon, B., Lopez-Novoa, J. M., Martin, P., Bustelo, X. R. Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions. Mol Cell Biol 2015; 35(-20-):3528-46. >>> Angiotensin II; ARL 67156; SC; mice; 1002; animal info: Vav1-/- and Vav2-/-; Vav3-/-mice (from C57BL/10); 3 months old; functionality of mp verified by blood pressure; dose-response (pg 3538); cardiovascular; peptides; enzyme inhibitor (ARL 67156 inhibits ecto-ATPase); Dose: 1.44 mg/kg (Ang II) ; 1.1 ug/kg/day (ARL 67156).

16117 Elkhatali, S., El-Sherbeni, A. A., Elshenawy, O. H., Abdelhamid, G., El-Kadi, A. O. 19-Hydroxyeicosatetraenoic acid and isoniazid protect against angiotensin II-induced cardiac hypertrophy. Toxicol Appl Pharmacol 2015; 289(-3-):550-9. >>> Angiotensin II; Saline; SC; rat; 1002; Controls received mp w/ vehicle; animal info: Male Sprague–Dawley rats weighing 190–210 g; functionality of mp verified by transthoracic echocardiography; blood pressure; dose-response (pg 556); cardiovascular; peptides; Dose: 450 ng/kg/min.

16109 Correll, R. N., Goonasekera, S. A., van Berlo, J. H., Burr, A. R., Accornero, F., Zhang, H., Makarewich, C. A., York, A. J., Sargent, M. A., Chen, X., Houser, S. R., Molkentin, J. D. STIM1 elevation in the heart results in aberrant Ca(2)(+) handling and cardiomyopathy. J Mol Cell Cardiol 2015; 87(--):38-47. >>> Isoproterenol; Angiotensin II; Phenylephrine; saline; SC; mice; 2002; Controls received mp w/ vehicle; animal info: STIM1 TG mice; functionality of mp verified by echocardiograph (ECG); cardiovascular; Dose: isoproterenol (60 mg/kg/d); angiotensin II (432Ǩg/kg/d) with phenylephrine (100 mg/kg/d),.

16097 Blazquez-Medela, A. M., Garcia-Sanchez, O., Quiros, Y., Blanco-Gozalo, V., Prieto-Garcia, L., Sancho-Martinez, S. M., Romero, M., Duarte, J. M., Lopez-Hernandez, F. J., Lopez-Novoa, J. M., Martinez-Salgado, C. Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations. Medicine (Baltimore) 2015; 94(-41-):e1617. >>> Angiotensin II; acetic acid; SC; rat; 1002; animal info: Wistar normotensive; functionality of mp verified by blood pressure levels, plasma levels; 0.01N of acetic acid; peptides; angiotensin II-independent model of hypertension, the DOCA salt model; Dose: 288 mg/kg/day.

16093 Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M., Griffin, M. Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol 2015; 22(-10-):1347-61. >>> Angiotensin II; TG2 inhibitor, compound 3h; DMSO; PBS; SC; mice; 1002; animal info: C57BL/6 male mice (14 weeks old); %50 of PBS; half-life (p.1360 ), 1 hr; antihypertensive; peptides; enzyme inhibitor (transglutaminase inhibitor); Dose: (AngII) 1.1 mg/kg/day; (compound 3h) 25 mg/kg/day.

16088 Zhou, C., Huang, J., Chen, J., Lai, J., Zhu, F., Xu, X., Wang, D. W. CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response. Cell Physiol Biochem 2016; 39(-2-):721-39. >>> Angiotensin II; SC; Mice; 1002; animal info (male, C57BL6J, 8 weeks old); cardiovascular; immunology; peptides; bp measured using tail-cuff; Dose (800 ug/kg/day);.

16080 Zhang, L., Ren, Z., Yang, Q., Ding, G. Csk regulates angiotensin II-induced podocyte apoptosis. Apoptosis 2016; 21(-7-):846-55. >>> Angiotensin II; Rat; Controls received mp w/ saline; animal info (male, SPF Wister, 140-160g); cardiovascular; peptides; Dose (400 ng/kg/min);.

16060 Wang, S., Chen, C., Su, K., Zha, D., Liang, W., Hillebrands, J. L., Goor, Hv, Ding, G. Angiotensin II induces reorganization of the actin cytoskeleton and myosin light-chain phosphorylation in podocytes through rho/ROCK-signaling pathway. Ren Fail 2016; 38(-2-):268-75. >>> Angiotensin II; telmisartan; IP; Rat; 2004; Controls received mp w/ saline; animal info (male, Sprague Dawley, 125g); cardiovascular; peptides; Dose (Angiotensin II 400 ng/kg/min; telmisartan 3 mg/kg/d);.

16057 Wang, H. W., Huang, B. S., White, R. A., Chen, A., Ahmad, M., Leenen, F. H. Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II - induced hypothalamic reactive oxygen species and hypertension. Neuroscience 2016; 329(--):112-21. >>> Angiotensin II; Saline; SC; Rat; 2001; 2002; Controls received no mp or vehicle; animal info (male, Wistar, 6-7 weeks old, 200-225g); cardiovascular; peptides; bp measured using radio telemetry (DSI); bp measured using radio telemetry (DSI);.

16054 Van Kempen, T. A., Narayan, A., Waters, E. M., Marques-Lopes, J., Iadecola, C., Glass, M. J., Pickel, V. M., Milner, T. A. Alterations in the subcellular distribution of NADPH oxidase p47(phox) in hypothalamic paraventricular neurons following slow-pressor angiotensin II hypertension in female mice with accelerated ovarian failure. J Comp Neurol 2016; 524(-11-):2251-65. >>> Angiotensin II; NaCl; BSA; SC; Mice; Controls received mp w/ vehicle; animal info (female, C57BL6, 2-3 months old); 0.01% BSA used; cardiovascular; peptides; pumps primed in 37C saline overnight; used 100 ul sized pump; bp measured using tail cuff; Dose (600 ng/kg/min);.

16048 Tsai, S. H., Huang, P. H., Hsu, Y. J., Peng, Y. J., Lee, C. H., Wang, J. C., Chen, J. W., Lin, S. J. Inhibition of hypoxia inducible factor-1alpha attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases. Sci Rep 2016; 6(--):28612. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (male, LDLR-/-, 8-10 weeks old); cardiovascular; peptides; Dose (1000 ng/kg/min);.

16042 Thirunavukkarasu, S., Khan, N. S., Song, C. Y., Ghafoor, H. U., Brand, D. D., Gonzalez, F. J., Malik, K. U. Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice. Am J Pathol 2016; 186(-8-):2204-19. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, ApoE Cyp1b1, 16 weeks old, 28-32g); cardiovascular; immunology; peptides; Dose (700 ng/kg/min);.

15998 Honjo, T., Chyu, K. Y., Dimayuga, P. C., Lio, W. M., Yano, J., Trinidad, P., Zhao, X., Zhou, J., Cercek, B., Shah, P. K. Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice. PLoS One 2015; 10(-6-):e0131731. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, apoE -/-, 10 weeks old); post op. care (SC analgesic); cardiovascular; immunology; peptides; Dose (1000 ng/kg/min);.

15996 Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J. J., Andersson, L. C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R., Alitalo, K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proc Natl Acad Sci U S A 2015; 112(-42-):13063-8. >>> Angiotensin II; SC; Mice; 1002; Controls received sham operation; animal info (C57BL6J or Bmx KO); cardiovascular; peptides;.

15985 Jang, J. H., Kang, M. J., Ko, G. P., Kim, S. J., Yi, E. C., Zhang, Y. H. Identification of a novel splice variant of neuronal nitric oxide synthase, nNOSbeta, in myofilament fraction of murine cardiomyocytes. Nitric Oxide 2015; 50(--):20-27. >>> Angiotensin II; SC; Rat; 2004; animal info (male, Sprague Dawley, 12 weeks old); cardiovascular; peptides; bp measured using tail cuff; Dose (125 ng/kg/min);.

15976 Krawczyk, K. K., Yao Mattisson, I., Ekman, M., Oskolkov, N., Grantinge, R., Kotowska, D., Olde, B., Hansson, O., Albinsson, S., Miano, J. M., Rippe, C., Sward, K. Myocardin Family Members Drive Formation of Caveolae. PLoS One 2015; 10(-8-):e0133931. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (male, C57Bl6J); stress/adverse reaction: (see pg. 5); cardiovascular; peptides;"Mini-pumps were used rather than daily injections to reduce stress."pg 5; Dose (1 mg/kg/min);.

15966 Lorenzen, J. M., Schauerte, C., Hubner, A., Kolling, M., Martino, F., Scherf, K., Batkai, S., Zimmer, K., Foinquinos, A., Kaucsar, T., Fiedler, J., Kumarswamy, R., Bang, C., Hartmann, D., Gupta, S. K., Kielstein, J., Jungmann, A., Katus, H. A., Weidemann, F., Muller, O. J., Haller, H., Thum, T. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. Eur Heart J 2015; 36(-32-):2184-96. >>> Angiotensin II; Water; SC; Mice; 2002; Controls received sham operation; animal info (OPN WT or OPN KO); cardiovascular; peptides; Dose (1.5 mg/kg/day);.

15959 Li, X. C., Shull, G. E., Miguel-Qin, E., Zhuo, J. L. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension. Physiol Genomics 2015; 47(-10-):479-87. >>> Angiotensin II; IP; Mice; 2002; Controls received mp w/ vehicle; animal info (male, Nhe3+/-, adult); functionality of mp verified by plasma levels; cardiovascular; bp measured using tail cuff; Dose (1.5 mg/kg/day);.

15936 Oosterhuis, N. R., Frenay, A. R., Wesseling, S., Snijder, P. M., Slaats, G. G., Yazdani, S., Fernandez, B. O., Feelisch, M., Giles, R. H., Verhaar, M. C., Joles, J. A., van Goor, H. DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats. Nitric Oxide 2015; 49(--):56-66. >>> Angiotensin II; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 261g); cardiovascular; peptides; Dose (435 ng/kg/min);.

15930 Pojoga, L. H., Yao, T. M., Opsasnick, L. A., Siddiqui, W. T., Reslan, O. M., Adler, G. K., Williams, G. H., Khalil, R. A. Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury. J Pharmacol Exp Ther 2015; 355(-1-):32-47. >>> Angiotensin II; L-NAME; SC; animal info (male, cav-1 KO, 12 weeks old); AngII infused to induce cardiovascular injury; Dose (L-NAME 0.1 - 0.2 mg/mL; AngII 0.7-2.8 mg/kg/day);.

15927 Pang, X. F., Zhang, L. H., Bai, F., Wang, N. P., Garner, R. E., McKallip, R. J., Zhao, Z. Q. Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats. Drug Des Devel Ther 2015; 9(--):6043-54. >>> Angiotensin II; Saline; SC; Rat; 2002; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200g); cardiovascular; peptides; pumps primed overnight in 37C saline, sterile; bp measured using tail cuff; Dose (150 mg/kg/day); increase in bp noted;.

15925 Phie, J., Haleagrahara, N., Newton, P., Constantinoiu, C., Sarnyai, Z., Chilton, L., Kinobe, R. Prolonged Subcutaneous Administration of Oxytocin Accelerates Angiotensin II-Induced Hypertension and Renal Damage in Male Rats. PLoS One 2015; 10(-9-):e0138048. >>> Angiotensin II; oxytocin; PBS; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 8-9 weeks old, 240-350g); post op. care (swabbed with 7.5% w/v iodine); cardiovascular; peptides; Dose (Ang II 40 ug/kg/h; OT 20 or 100 ng/kg/h);.

15920 Nakayama, A., Morita, H., Nakao, T., Yamaguchi, T., Sumida, T., Ikeda, Y., Kumagai, H., Motozawa, Y., Takahashi, T., Imaizumi, A., Hashimoto, T., Nagai, R., Komuro, I. A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling. PLoS One 2015; 10(-9-):e0137106. >>> Angiotensin II, [Val5]-; PBS; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old); cardiovascular; peptides; bp measured using tail cuff; Dose (0.7 mg/kg/min);.

15919 Nakashima, T., Umemoto, S., Yoshimura, K., Matsuda, S., Itoh, S., Murata, T., Fukai, T., Matsuzaki, M. TLR4 is a critical regulator of angiotensin II-induced vascular remodeling: the roles of extracellular SOD and NADPH oxidase. Hypertens Res 2015; 38(-10-):649-55. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, WT, 12-16 weeks old); cardiovascular; peptides; bp measured using tail cuff; Dose (Angiotensin II 1.1 mg/kg/day; norepinephrine 5.6 mg/kg/day);.

15915 Kelloniemi, A., Aro, J., Napankangas, J., Koivisto, E., Mustonen, E., Ruskoaho, H., Rysa, J. TSC-22 up-regulates collagen 3a1 gene expression in the rat heart. BMC Cardiovasc Disord 2015; 15(--):122. >>> Angiotensin II; losartan; saline; SC; Rat; Controls received mp w/ vehicle; animal info (male, SHR or WKY, 12-20 months old); cardiovascular; peptides;.

15912 Jin, H. Y., Chen, L. J., Zhang, Z. Z., Xu, Y. L., Song, B., Xu, R., Oudit, G. Y., Gao, P. J., Zhu, D. L., Zhong, J. C. Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling. J Transl Med 2015; 13(--):255. >>> Angiotensin II; Saline; Mice; 1002; Controls received mp w/ vehicle; animal info (male, ApoEKO, 12 weeks old); cardiovascular; peptides; Dose (1.5 mg/kg/day);.

15907 Gallego-Delgado, J., Baravian, C., Edagha, I., Ty, M. C., Ruiz-Ortega, M., Xu, W., Rodriguez, A. Angiotensin II Moderately Decreases Plasmodium Infection and Experimental Cerebral Malaria in Mice. PLoS One 2015; 10(-9-):e0138191. >>> Angiotensin II; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; Controls received mp w/ vehicle; cardiovascular; immunology;"Since Ang II is rapidly degraded in plasma, to experimentally modify the levels of Ang II in mice, it is required to implant intra-dermal micro-pumps that provide a constant delivery of Ang II into the blood"pg 5; Dose (100 or 500 ng/kg/min);.

15872 Ren, H., Li, F., Tian, C., Nie, H., Wang, L., Li, H. H., Zheng, Y. Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice. Sci Rep 2015; 5(--):15730. >>> Angiotensin II; Saline; Mice; 2004; Controls received mp w/ vehicle; animal info (male, ApoE -/-, 10 weeks old); cardiovascular; peptides; Dose (1000 ng/kg/min);.

15860 Xiyan Zhang, MD,, Fanqing Meng, MD,, Jie Song, MD,, Li Zhang, MD, PhD,, Jiali Wang, MD,, Dongliang Li, MD, PhD,, Liang Li, MD,, Ping Dong, MD,, Bo Yang, MD,, Yuguo Chen, MD, PhD  J Cardiovasc. Pharmacol 2016; 67(-1-):76-85. >>> Angiotensin II; SC; Rat; 2002; animal info (male, Sprague Dawley, 250-300g); animal info (male, Sprague Dawley, 250-300g); immunology; peptides; bp measured using tail cuff; Dose (200 ng/kg/min);.

15855 Yang, Q., Ma, Y., Liu, Y., Liang, W., Chen, X., Ren, Z., Wang, H., Singhal, P. C., Ding, G. Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl. Mol Biol Cell 2016; 27(-1-):197-208. >>> Angiotensin II; Rat; 2002; 2004; Controls received mp w/ saline; animal info (male, Wistar, 140-160g); cardiovascular; peptides; Dose (400 ng/kg/min);.

15847 Baojian Xue, Robert L. Thunhorst, Yang Yu, Fang Guo, Terry G. Beltz, Robert B. Felder,, Alan Kim Johnson  Hypertension 2016; 67(--):163-170. >>> Pentoxifylline; irbesartan; minocycline; angiotensin II; CSF, artificial; Na sodium bicarbonate; saline; CSF/CNS; Rat; 2004; 2002; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10-12 weeks old); cardiovascular; peptides; Dose (ICV - Pentoxifylline 10 ug/hr; irbesartan 125 ug/day; minocycline 5 ug/hr; SC AngII 120 ng/kg/min); brain coordinates;.

15837 Renjun Wang, PhD; Qian Huang, MD; Rui Zhou, BSc; Zengxiang Dong, PhD;, Yunfeng Qi, PhD; Hua Li, MS; Xiaowei Wei, MS; Hui Wu, MS; Huiping Wang, PhD;, Christopher S. Wilcox, MD, PhD; Michael Hultström, MD, PhD; Xiaofu Zhou, PhD;, En Yin Lai, MD, PhD  Circ Heart Fail. 2016; 9(--):1-10. >>> AntagomiR-7b; RNA, small interfering GABBR1; angiotensin II; CSF/CNS (paraventricular nucleus); Rat; 1004; 1002; animal info (male, Wistar, 180-200g); pumps replaced after 4 weeks; bilateral cannula used; tissue perfusion (paraventricular nucleus); cardiovascular; peptides; bilateral infusion; Dose (AntagomiR-7b or Ad-siGABBR1 40 ng/h; antiotensin II 1 ng/kg/min);.

15827 Tiju Theccanat, Jennifer L. Philip, Abdur M. Razzaque, Nicholas Ludmer, Jinju Li, Xianyao Xu, Shahab A. Akhter  Cellular Signalling 2016; 28(--):190-203. >>> Angiotensin II; isoproterenol; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL-6N, 6 weeks old); cardiovascular; peptides; Dose (Iso 17 mg/kg/day; Ang II 1.8 mg/kg/day);.

15822 Yue Shen,, Fang Cheng,, Mehul Sharma,, Yulia Merkulova,, Sheetal A. Raithatha,, Leigh G. Parkinson,, Hongyan Zhao,, Kathryn Westendorf,, Lubos Bohunek,, Tatjana Bozin, Ivy Hsu,, Lisa S. Ang, Sarah J. Williams,, R. Chris Bleackle, John E. Eriksson,, Michael A. Seidman,, Bruce M. McManus,, David J. Granville  Am J Pathol 2016; 186(--):87-100. >>> Angiotensin II; SC; Mice; 1004; Controls received mp w/ saline; animal info (male, C57BL6J, 3-4 months old); post op. care (SC buprenorphine injection); cardiovascular; peptides; pumps primed 24 hours in 37C saline; bp measured using tail cuff; Dose (1000 ng/kg/min);.

15815 Tanja K. Rudolph, Thorben Ravekes, Anna Klinke, Kai Friedrichs, Martin Mollenhauer, Michaela Pekarova, Gabriela Ambrozova, Hana Martiskova, Jatinder-Jit Kaur, Bianca Matthes, Alex Schwoerer, Steven R.Woodcock, Lukas Kubala, Bruce A. Freeman, Stephan Baldus, Volker Rudolph  Cardiovascular Research 2016; 109(--):174-184. >>> Nitro-octadec-9-enoic acid, 10-; angiotensin II; PEG; ethanol; SC; Mice; Controls received mp w/ vehicle; animal info (C57Bl6J); functionality of mp verified by plasma levels; 90% PEG used; 10% ethanol used; cardiovascular; peptides; Dose (Nitro-octadec-9-enoic acid, 10- 6 mg/kg; angiotensin II 1.5 ng/g/min);.

15814 Ashbeel Roy,, Mouhamed Dakroub,, Geisa C. S. V. Tezini, Yin Liu,, Silvia Guatimosim,, Qingping Feng,, Helio C. Salgado,, Vania F. Prado,, Marco A. M. Prado, and Robert Gros  FASEB J 2016; 30(--):688-701. >>> Angiotensin II; Saline, sterile; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male,VAChT or WT, 3-6 months old); cardiovascular; peptides; Dose (3 mg/kg/day);.

15812 A. Ramesh, P. A. Prins, P. R. Perati, P. V. Rekhadevi, U. K. Sampson  MOLECULAR AND CELLULAR BIOCHEMISTRY 2016; 41(-1-):383-391. >>> Angiotensin II; SC; Mice; 2004; animal info (male, ApeE -/-, 7 weeks old); peptides; cardiovascular; Dose (1000 ng/kg/min);.

15808 Paramita Pati, David J.R. Fulton, Zsolt Bagi, Feng Chen,, Yusi Wang, Julia Kitchens, Lisa A. Cassis, David W. Stepp, R. Daniel Rudic  Hypertension 2016; 67(--):661-668. >>> Angiotensin II; SC; Mice; 2004; animal info (male, WT or Per2-KO, 4-6 months old); cardiovascular; peptides; bp measured using radiotelemetry; Dose (1000 ng/kg/min);.

15803 Akiyuki Nishimura,, Caroline Sunggip,, Hidetoshi Tozaki-Saitoh,, Tsukasa Shimauchi,, Takuro Numaga-Tomita,, Katsuya Hirano,, Tomomi Ide, Jean-Marie Boeynaems,, Hitoshi Kurose,, Makoto Tsuda,, Bernard Robaye,, Kazuhide Inoue, Motohiro Nishida  Science Signaling 2016; 9(-411-):. >>> Angiotensin II; PBS; IP; Mice; Controls received mp w/ vehicle; animal info (male, P2Y6R heterozygotes, 8 weeks old); cardiovascular; peptides; bp measured using tail cuff; Dose (2 mg/kg/day);.

15795 Ming-Ming Ma, Cai-Xia Lin, Can-Zhao Liu, Min Gao,, Lu Sun,, Yong-Bo, Tang, Jia-Guo Zhou,, Guan-Lei Wang, Yong-Yuan Guan  British J. Pharmacol 2016; 173(--):529-544. >>> Angiotensin II; Y27632; Saline; acetic acid; SC; Mice; Controls received mp w/ vehicle; animal info (male, ClC-3 null or WT, 18-22g); cardiovascular; peptides;“The animal recovered within 2 hours after the operation. All of the mice implanted with AngII infused pump developed hypertension within 2 weeks and there was no associated mortality.” pg 532; bp measured using tail cuff; Dose (Ang II 1.5 mg/kg/day; Y27632 3 mg/kg/day);.

15793 Shenglan Liu, Shaorui Chen, Min Li, Boyu Zhang, Peiye Shen, Peiqing Liu, Dandan Zheng, Yijie Chen, Jianmin Jiang  Archives Biochem. Biophys 2016; 590(--):37-47. >>> Angiotensin II; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL6, 20-25g); cardiovascular; cardiovascular;.

15792 Li Lin, Xuebo Liu, Jianfeng Xu, Liqing Weng, Jun Ren, Junbo Ge, Yunzeng Zou  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2016; 20(-1-):48-57. >>> Angiotensin II; angiotensin (1-7); A779; SC; Mice; 2002; animal info (male, C57BL6, 8-10 weeks old); Dose (Angiotensin II 1000 ng/kg/min; angiotensin (1-7) 500 ug/kg/day; A779 500 ug/kg/day);.

15791 Victor V. Lima, Saiprasad M. Zemse, Chin-Wei Chiaoc,, Gisele F. Bomfimd,, Rita C. Tostes, R. Clinton Webb, Fernanda R. Giachini  Life Sci 2016; 145(--):137-143. >>> Angiotensin II; interleukin-10, recombinant mouse;; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, IL-10 -/- or WT, 10-12 weeks old); functionality of mp verified by plasma levels; immunology; bp measured using catheter; Dose (Ang II 90 ng/min; IL-10 0.5 ng/min);.

15784 Woo-Young Kwon, Hye-Na Cha, Jung-Yoon Heo, Jung-Hyun Choi, Byung Ik Jang, In-Kye Lee, So-Young Park  Life Sci 2016; 146(--):214-221. >>> Angiotensin II; SC; Mice; animal info (male, IL-10 KO, 8 weeks old; cardiovascular; immunology; peptides; Dose (1.1 mg/kg/day).

15783 S M Krishnan, J K Dowling, Y H Ling, H Diep, C T Chan, D Ferens, M M Kett, A Pinar, C S Samuel, A Vinh, T V Arumugam, T D Hewitson, B K Kemp-Harper, A A B Robertson, M A Cooper, E Latz, A Mansell, C G Sobey, G R Drummond  British J. Pharmacol 2016; 173(--):752-765. >>> Angiotensin II; MCC950; Angiotensin II; MCC950; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, WT or ASC -/-, 10-12 weeks, 25-30g); cardiovascular; immunology; peptides; enzyme inhibitor (NLRP3 inflammasome; MCC950 is a novel diarylsulfonylurea-based compound; bp measured using tail cuff; Dose (0.7 mg/kg/day);.

15781 Libor Kopkan, Zuzana Huskova, SƏa´rka J•´chova, Lenka CƏervenkova, LudeƏk CƏervenka, Zubaida Saifudeen, Samir S. El-Dahr  Clinical&EXPERIMENTAL Hypertension 2016; 38(-1-):1-9. >>> Angiotensin II; SC; Mice; 1004; animal info (UB Bdkrb2-/- or Bdkrb2 flox/flox, 10-16 weeks old); functionality of mp verified by plasma levels; cardiovascular; peptides; bp measured using radiotelemetry (DSI); Dose (100 ng/kg/min); good bp graph;.

15776 Danfeng Jiang,, Mariko Tokashiki,, Hidetaka Hayashi,, Yukiko Kawagoe,, Kenji Kuwasako,, Kazuo Kitamura,, Johji Kato1  American Journal of Hypertension 2016; 29(-2-):163-169. >>> Angiotensin II; Acetic acid; SC; Rat; Rat; Controls received mp w/ vehicle; animal info (male, Wister, 13-14 weeks old); cardiovascular; peptides; BP measured using radiotelemetry; Dose (240 pmol/kg/min);.

15772 Chunyan Hu, Ko-Ting Lu, Masashi Mukohda, Deborah R. Davis, Frank M. Faraci, Curt D. Sigmund  PHYSIOLOGICAL GENOMICS 2016; 48(--):124-134. >>> Angiotensin II; Saline, isotonic; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, E-V290M, 3-6 months old); cardiovascular; peptides; bp measured using radiotelemetry; bp measured using radiotelemetry;.

15766 Ba´rbara Gonza´lez-Tera´n, Juan Antonio Lo´pez, Elena Rodr•´guez, Luis Leiva, Sara Mart•´nez-Mart•´nez, Juan Antonio Bernal, Luis Jesu´s Jime´nez-Borreguero, Juan Miguel Redondo, Jesu´s Vazquez, Guadalupe Sabio  Nature Communications 2016; (--):1-16. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (male, p38g deficient, 9 weels p;d); cardiovascular; peptides; bp measured using tail cuff; Dose (1 ug/kg/min);.

15761 Paul Fransen, Cor E. Van Hove, Arthur J. A. Leloup, Dorien M. Schrijvers, Guido R. Y. De Meyer, Gilles W. De Keulenaer  pflugers Arch - Eur J physiol 2016; 468(--):257-267. >>> Angiotensin II; SC; Mice; 1004; Controls received mp w/ saline; animal info (male, C57BL6J); animal info (male, C57BL6J); peptides; bp measured using tail cuff; bp measured using tail cuff;.

15739 Sandra L. Burke,, Elena V. Lukoshkova, and Geoffrey A. Head  Experimental Physiology 2016; 101(-1-):50-66. >>> Angiotensin II; SC; Rabbit; 2ML4; Controls received dummy pump; animal info (male, New Zealand White, 2.4-2.7 kg); pumps replaced every 4 weeks; Dose (20 ng/kg/min for 8 weeks or 50 ng/kg/min for 4 weeks);.

15738 Corinna S B€urgin-Maunder,, Maria Nataatmadja,, Rebecca K Vella,, Andrew S Fenning,, Peter R Brooks, and Fraser D Russell  Clinical and Experimental Pharmacology and Physiology 2016; (-43-):174-181. >>> Angiotensin II; SC; Mice; 1002; animal info (male, ApoE -/-, 3-4 weeks old); cardiovascular; peptides; Dose (1000 ng/kg/min);.

15736 Kathrin Broekmans,, Johannes Stegbauer,, Sebastian A. Potthoff,, Michael Russwurm,, Doris Koesling,, and Evanthia Mergia  The Journal of Pharmacology and Experimental Therapeutics 2016; (-356-):191-199. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 1002; animal info (male, NO-GC1 KO, 2-3 months old); cardiovascular; peptides; bp measured using tail cuff or radiotelemetry (DSI); Dose (Ang II 1.44 mg/kg/day; NE 2.88 mg/kg/day);good bp graph;.

14955 Haggerty, C.M., Mattingly, A.C., Gong, M.C., Su, W., Daugherty, A., Fornwalt, B.K., Fornwalt, B.K. Telemetric Blood Pressure Assessment in Angiotensin II-Infused ApoE(-/-) Mice: 28 Day Natural History and Comparison to Tail-Cuff Measurements. PLoS One 2015; 10(--):U2162-U2175. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (male, ApoE -/-, 9 weeks old); cardiovascular; peptides;.

15187 Patel, J., McNeill, E., Douglas, G., Hale, A.B., de Bono, J., Lee, R., Iqbal, A.J., Regan-Komito, D., Stylianou, E., Greaves, D.R., Channon, K.M., Patel, J. RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nature Communications 2015; 6(--):U1-U11. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (male, ApoE -/- or Rgs1 -/-, 8-16 weeks old); cardiovascular; immunology; peptides; bp measured using tail cuff;.

15173 Zhang, X.J., He, C.W., Tian, K., Li, P., Su, H.X., Wan, J.B., Wan, J.B. Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways. VASCULAR PHARMACOLOGY 2015; 73(--):86-95. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, ApoE -/-, 14-16 weeks old); cardiovascular; peptides;.

15172 Zhang, X., Thatcher, S., Wu, C.Q., Daugherty, A., Cassis, L.A., Cassis, L.A. Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms. JOURNAL OF VASCULAR SURGERY 2015; 61(--):767-776. >>> Angiotensin II; SC; Mice; 1004; Animal info (male, ApoE -/-, 2 months old, orchiectomy); pumps replaced every month; long-term study; cardiovascular; peptides;.

15163 Yu, Y., Xue, B.J., Wei, S.G., Zhang, Z.H., Beltz, T.G., Guo, F., Johnson, A.K., Felder, R.B., Felder, R.B. Activation of Central PPAR-gamma Attenuates Angiotensin II-Induced Hypertension. HYPERTENSION 2015; 66(--):403-411. >>> Angiotensin II; pioglitazone, GW9662; DMSO; CSF, artificial; SC; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); functionality of mp verified by residual volume; 20% DMSO used; Multiple pumps per animal (2); cardiovascular; immunology; peptides; Cannula placement verified via histologic analysis of cannula track; bp measured using radiotelemetry (DSI);.

15161 Yu, C., Luo, X.Y., Duquette, N., Thorin-Trescases, N., Thorin, E., Thorin, E. Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H386-H397. >>> Angiotensin II; SC; Mice; 1002; Controls received mp w/ saline; animal info (male, angptl2 KO or WT, 20-22 weeks old); cardiovascular; peptides; bp measured using tail-cuff and Millar catheter;.

15160 Young, C.N., Li, A.F., Dong, F.N., Horwath, J.A., Clark, C.G., Davisson, R.L., Davisson, R.L. Endoplasmic reticulum and oxidant stress mediate nuclear factor-kappaB activation in the subfornical organ during angiotensin II hypertension. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2015; 308(--):C803-C812. >>> Angiotensin II, human; BSA; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6, 8-10 weeks old); 0.1% BSA used; cardiovascular; peptides; pumps primed overnight at 37C; bp measured using radiotelemetry;.

15159 Yoshihara, T., Shimada, K., Fukao, K., Sai, E., Sato-Okabayashi, Y., Matsumori, R., Shiozawa, T., Alshahi, H., Miyazaki, T., Tada, N., Daida, H., Shimada, K. Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation. CIRCULATION JOURNAL 2015; 79(--):1470-U292. >>> Angiotensin II; SC; Mice; 1004; Controls received mp w/ saline; animal info (male, ApoE -/-, 12 weeks old); cardiovascular; immunology; peptides; bp measured using tail cuff;.

15158 Yoshihara, F., Tokudome, T., Kishimoto, I., Otani, K., Kuwabara, A., Horio, T., Kawano, Y., Kangawa, K., Yoshihara, F. Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides. Clinical and Experimental Nephrology 2015; 19(--):197-207. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (male, GC-A-KO, 10 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

15154 Yang, L., Ni, L., Duan, Q.L., Wang, X.X., Chen, C., Chen, S., Chaugai, S., Zeldin, D.C., Tang, J.R., Wang, D.W., Tang, J.R. CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. PROSTAGLANDINS&OTHER LIPID MEDIATORS 2015; 116(--):64-75. >>> Isoproterenol; angiotensin II; Ascorbic acid; saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, CYP2J2 Tg or WT C57BL6); 0.002% ascorbic acid used; cardiovascular; immunology; peptides; bp measured using catheter;.

15147 Xue, B.J., Zhang, Z.M., Beltz, T.G., Guo, F., Hay, M., Johnson, A.K., Xue, B.J. Genetic knockdown of estrogen receptor-alpha in the subfornical organ augments ANG II-induced hypertension in female mice. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 308(--):R507-R516. >>> Angiotensin II; SC; Mice (transgenic); 1002; Animal info (female, ERa); cardiovascular; peptides; bp measured using radiotelemetry (DSI TA11PA-C10);.

15146 Xie, X.L., Nie, X., Wu, J., Zhang, F., Zhao, L.L., Lin, Y.L., Yin, Y.J., Liu, H., Shu, Y.N., Miao, S.B., Li, H., Chen, P., Han, M., Han, M. Smooth muscle 22alpha facilitates angiotensin II-induced signaling and vascular contraction. JOURNAL OF MOLECULAR MEDICINE-JMM 2015; 93(--):547-558. >>> Angiotensin II; SC; Mice; Animal info (male, WT or Sm22a -/-, 10 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

15140 Weng, X.Y., Yu, L.M., Liang, P., Chen, D.W., Cheng, X., Yang, Y.Y., Li, L.Y., Zhang, T., Zhou, B.S., Wu, X.Y., Xu, H.H., Fang, M.M., Gao, Y.Q., Chen, Q., Xu, Y., Fang, M.M. Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 80(--):23-33. >>> Angiotensin II; SC; Mice; 2004; Animal info (male, C57BL6, 8 weeks old); cardiovascular; peptides;.

15139 Weng, X.Y., Yu, L.M., Liang, P., Li, L.Y., Dai, X., Zhou, B.S., Wu, X.Y., Xu, H.H., Fang, M.M., Chen, Q., Xu, Y., Fang, M.M. A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 82(--):48-58. >>> Angiotensin II; SC; Mice; 2004; Animal info (male, 8 weeks old); cardiovascular; peptides;.

15120 Trachet, B., Fraga-Silva, R.A., Londono, F.J., Swillens, A., Stergiopulos, N., Segers, P., Trachet, B. Performance Comparison of Ultrasound-Based Methods to Assess Aortic Diameter and Stiffness in Normal and Aneurysmal Mice. PLoS One 2015; 10(--):U1707-U1726. >>> Angiotensin II; angiotensin (1-7); angiotensin (1-7), D-ala7-; Saline, sterile; SC; Mice; 2004; Controls received no mp; animal info (male, ApoE-/-, 20 weeks old); stress/adverse reaction: (see pg. 3); post op. care (buprenorphine 0.08 mg/kg SC); cardiovascular; peptides;.

15119 Toth, P., Tarantini, S., Springo, Z., Tucsek, Z., Gautam, T., Giles, C.B., Wren, J.D., Koller, A., Sonntag, W.E., Csiszar, A., Ungvari, Z., Ungvari, Z. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. AGING CELL 2015; 14(--):400-408. >>> Angiotensin II; Saline, sterile; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6, 3 or 24 months old); behavioral testing (gait analysis, spontaneous activity); cardiovascular; peptides;.

15116 Tokola, H., Rysae, J., Pikkarainen, S., Hautala, N., Leskinen, H., Kerkelae, R., Ilves, M., Aro, J., Vuolteenaho, O., Ritvos, O., Ruskoaho, H., Ruskoaho, H. Bone morphogenetic protein-2-A potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2015; 399(--):9-21. >>> Angiotensin II; Saline; Rat; Controls received mp w/ vehicle; animal info (Sprague Dawley, 2-4 days old); cardiovascular; peptides;.

15101 Tang, G.B., Tang, X.F., Li, K., Wang, D.H., Tang, G.B. Intracerebroventricular administration of leptin increase physical activity but has no effect on thermogenesis in cold-acclimated rats. SCIENTIFIC REPORTS 2015; 5(--):U1-U7. >>> Angiotensin II; CSF, artificial; CSF/CNS; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, adult); behavioral testing (physical activity); Cannula placement verified via drinking response;.

15098 Tajima, S., Ikeda, Y., Enomoto, H., Imao, M., Horinouchi, Y., Izawa-Ishizawa, Y., Kihira, Y., Miyamoto, L., Ishizawa, K., Tsuchiya, K., Tamaki, T., Ikeda, Y. Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice. EUROPEAN JOURNAL OF NUTRITION 2015; 54(--):709-719. >>> Angiotensin II; SC; Mice; 1004; Animal info (male, C57BL6J, 6 weeks old); cardiovascular; immunology; peptides;.

15093 Sun, W.L., Pang, Y.L., Liu, Z.Y., Sun, L.L., Liu, B., Xu, M.J., Dong, Y.Q., Feng, J., Jiang, C.T., Kong, W., Wang, X., Kong, W. Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 81(--):96-106. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (ApoE -/-); cardiovascular; immunology; peptides;.

15257 Sumida, T., Naito, A.T., Nomura, S., Nakagawa, A., Higo, T., Hashimoto, A., Okada, K., Sakai, T., Ito, M., Yamaguchi, T., Oka, T., Akazawa, H., Lee, J.K., Minamino, T., Offermanns, S., Noda, T., Botto, M., Kobayashi, Y., Morita, H., Manabe, I., Nagai, T., Shiojima, I., Komuro, I., Komuro, I. Complement C1q-induced activation of beta-catenin signalling causes hypertensive arterial remodelling. Nature Communications 2015; 6(--):U43-U54. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (male, C57BL/6, 8-10 weeks old); cardiovascular; peptides; bp measured using tail cuff; long-term study;.

15086 Song, J., Zhu, Y., Li, J.T., Liu, J.H., Gao, Y., Ha, T.Z., Que, L.L., Liu, L., Zhu, G.Q., Chen, Q., Xu, Y., Li, C.F., Li, Y.H., Li, Y.H. Pellino1-mediated TGF-beta1 synthesis contributes to mechanical stress induced cardiac fibroblast activation. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 79(--):145-156. >>> Angiotensin II; SC; Rat; 2004; Controls received mp w/ saline; animal info (male, Sprague Dawley, 180-220g); cardiovascular; peptides;.

15079 Shen, M.C., Lee, J., Basu, R., Sakamuri, S.S.V.P., Wang, X.H., Fan, D., Kassiri, Z., Kassiri, Z. Divergent Roles of Matrix Metalloproteinase 2 in Pathogenesis of Thoracic Aortic Aneurysm. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2015; 35(--):888-898. >>> Angiotensin II; Mice; Controls received mp w/ saline; animal info (WT or MMP2 -/-); cardiovascular; peptides; bp measured using tail cuff;.

15065 Prasad, A.M., Morgan, D.A., Nuno, D.W., Ketsawatsomkron, P., Bair, T.B., Venema, A.N., Dibbern, M.E., Kutschke, W.J., Weiss, R.M., Lamping, K.G., Chapleau, M.W., Sigmund, C.D., Rahmouni, K., Grumbach, I.M., Grumbach, I.M. Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II-Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2015; 4(--):U228-U243. >>> Angiotensin II; PBS; SC; Mice (transgenic); 1002; Controls received mp w/ vehicle; animal info (CaMKIIN, 10-12 weeks old); cardiovascular; peptides; bp measured by radiotelemetry (DSI);.

15063 Polichnowski, A.J., Griffin, K.A., Picken, M.M., Licea-Vargas, H., Long, J.R., Williamson, G.A., Bidani, A.K., Polichnowski, A.J. Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F252-F260. >>> Angiotensin II; SC; Rat; 2ML4; Animal info (male, Sprague Dawley, 250-350g); cardiovascular; peptides; bp measured using radiotelemetry (DSI);.

15058 Phillips, E.H., Yrineo, A.A., Schroeder, H.D., Wilson, K.E., Cheng, J.X., Goergen, C.J., Phillips, E.H. Morphological and Biomechanical Differences in the Elastase and AngII apoE(-/-) Rodent Models of Abdominal Aortic Aneurysms. BIOMED RESEARCH INTERNATIONAL 2015; ;(--):U1-U12. >>> Angiotensin II; NaCl; SC; Mice; 2004; Animal info (B6.129P2-Apoe tm1Unc/J, 20-36g, 17 +/-7.8 weeks old); cardiovascular; peptides; bp measured using tail cuff; pumps primed for 12 hours in saline;.

15043 Moilanen, A.M., Rysae, J., Kaikkonen, L., Karvonen, T., Mustonen, E., Serpi, R., Szabo, Z., Tenhunen, O., Bagyura, Z., Naepaenkangas, J., Ohukainen, P., Tavi, P., Kerkelae, R., Leosdottir, M., Wahlstrand, B., Hedner, T., Melander, O., Ruskoaho, H., Ruskoaho, H. WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function. PLoS One 2015; 10(--):U1259-U1290. >>> Angiotensin II; SC; Rat; Animal info (male, Sprague Dalwey, 250-300g); cardiovascular; peptides;.

15042 Mohammed-Ali, Z., Cruz, G.L., Lu, C., Carlisle, R.E., Werner, K.E., Ask, K., Dickhout, J.G., Dickhout, J.G. Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with Properties of Progressive Human CKD. BIOMED RESEARCH INTERNATIONAL 2015; ;(--):U1-U10. >>> Angiotensin II; Water, sterile; SC; Mice; 1004; Animal info (C57BL6, 10 weeks old); cardiovascular; peptides;.

15037 Matsuo, Y., Gleitsmann, K., Mangner, N., Werner, S., Fischer, T., Bowen, T.S., Kricke, A., Matsumoto, Y., Kurabayashi, M., Schuler, G., Linke, A., Adams, V., Adams, V. Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 2015; 6(--):62-72. >>> Angiotensin II; Saline, normal; SC; Mice; 2004; Animal info (ApoE -/-, 4 weeks old, 20g); cardiovascular; immunology; peptides;.

15036 Matsuo, K., Shibata, R., Ohashi, K., Kambara, T., Uemura, Y., Hiramatsu-Ito, M., Enomoto, T., Yuasa, D., Joki, Y., Ito, M., Hayakawa, S., Ogawa, H., Kihara, S., Murohara, T., Ouchi, N., Shibata, R. Omentin functions to attenuate cardiac hypertrophic response. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 79(--):195-202. >>> Angiotensin II; SC; Mice; Animal info (male, WT, 8-10 weeks old); cardiovascular; peptides;.

15033 Marques-Lopes, J., Lynch, M.K., Van Kempen, T.A., Waters, E.M., Wang, G., Iadecola, C., Pickel, V.M., Milner, T.A., Marques-Lopes, J. Female Protection From Slow-Pressor Effects of Angiotensin II Involves Prevention of ROS Production Independent of NMDA Receptor Trafficking in Hypothalamic Neurons Expressing Angiotensin 1A Receptors. SYNAPSE 2015; 69(--):148-165. >>> Angiotensin II; Saline; BSA; SC; Mice; Controls received mp w/ vehicle; animal info (AT1ar-EGFP); 0.01% BSA used; cardiovascular; peptides; bp measured using tail cuff;.

15025 Lu, H.Y., Huang, C.Y., Shih, C.M., Chang, W.H., Tsai, C.S., Lin, F.Y., Shih, C.C., Lin, F.Y. Dipeptidyl Peptidase-4 Inhibitor Decreases Abdominal Aortic Aneurysm Formation through GLP-1-Dependent Monocytic Activity in Mice. PLoS One 2015; 10(--):U134-U151. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (male, ApoE -/-, 12-14 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

15018 Domes, K., Patrucco, E., Loga, F., Dietrich, A., Birnbaumer, L., Wegener, J.W., Hofmann, F., Hofmann, F. Murine cardiac growth, TRPC channels, and cGMP kinase I. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2015; 467(--):2229-2234. >>> Angiotensin II; SC; Mice; 1007D; Controls received sham operation; animal info (male, TKObRM, 2-3 months old); cardiovascular; peptides;.

15014 Cantalupo, A., Zhang, Y., Kothiya, M., Galvani, S., Obinata, H., Bucci, M., Giordano, F.J., Jiang, X.C., Hla, T., Di Lorenzo, A., Di Lorenzo, A. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. NATURE MEDICINE 2015; 21(--):1028-+. >>> Angiotensin II; SC; Mice; 2004; Animal info (male, WT or Nogo-A/B-deficient, 10 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

15012 Liu, C.F., Zhang, J., Shen, K., Gao, P.J., Wang, H.Y., Jin, X., Meng, C., Fang, N.Y., Fang, N.Y. Adventitial gene transfer of catalase attenuates angiotensin II-induced vascular remodeling. Molecular Medicine Reports 2015; 11(--):2608-2614. >>> Angiotensin II; SC; Rat; 2002; Animal info (male, Sprague Dawley, 6-8 weeks old, 150-200g); cardiovascular; peptides; bp measured using tail cuff;.

15008 Li, N., Wang, H.X., Han, Q.Y., Li, W.J., Zhang, Y.L., Du, J., Xia, Y.L., Li, H.H., Xia, Y.L. Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 79(--):303-314. >>> Angiotensin II; Mice; Controls received mp w/ saline; animal info (male, C57BL6, 10-12 weeks old); cardiovascular; peptides;.

15001 Larson, R.A., Gui, L., Huber, M.J., Chapp, A.D., Zhu, J.H., LaGrange, L.P., Shan, Z.Y., Chen, Q.H., Chen, Q.H. Sympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H1547-H1555. >>> Angiotensin II; SC; Rat; 2ML2; Animal info (male, Sprague Dalwey, 200-200g); cardiovascular; peptides; bp measured using catheter;.

14988 Kecskes, M., Jacobs, G., Kerselaers, S., Syam, N., Menigoz, A., Vangheluwe, P., Freichel, M., Flockerzi, V., Voets, T., Vennekens, R., Vennekens, R. The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy. BASIC RESEARCH IN CARDIOLOGY 2015; 110(--):U156-U169. >>> Angiotensin II; SC; Mice; 1002; Controls received mp w/ saline; animal info (Cre -/+/+ or Cre +/+/+, 8-12 weeks old); cardiovascular; peptides;.

14987 Kawahata, H., Sotobayashi, D., Aoki, M., Shimizu, H., Nakagami, H., Ogihara, T., Morishita, R., Aoki, M. Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. HYPERTENSION RESEARCH 2015; 38(--):382-393. >>> Angiotensin II; olmesartan; hydralazine; Saline; sodium bicarbonate; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (female, C57BL/6NJ, 20-22g); dose-response (p. 385); cardiovascular; antihypertensive; peptides; bp measured using tail cuff;.

14991 Kato, H., Ishida, J., Matsusaka, T., Ishimaru, T., Tanimoto, K., Sugiyama, F., Yagami, K., Nangaku, M., Fukamizu, A., Fukamizu, A. Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. PLoS One 2015; 10(--):U1003-U1017. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, Agt KO, Ren KO, AT1a KO, 3 months old); cardiovascular; peptides; bp measured using tail cuff;.

14989 Jo, F., Jo, H., Hilzendeger, A.M., Thompson, A.P., Cassell, M.D., Rutkowski, D.T., Davisson, R.L., Grobe, J.L., Sigmund, C.D., Sigmund, C.D. Brain Endoplasmic Reticulum Stress Mechanistically Distinguishes the Saline-Intake and Hypertensive Response to Deoxycorticosterone Acetate-Salt. HYPERTENSION 2015; 65(--):1341-U330. >>> Tauroursodeoxycholic acid; angiotensin II; CSF, artifical; CSF/CNS; SC; Mice; Controls received mp w/ vehicle; animal info (CHOP-deficient or C57BL6J, 6 weeks old); cardiovascular; peptides; Tauroursodeoxycholic acid aka TUDCA; used Plastics One cannula;.

14979 Jennings, B.L., Moore, J.A., Pingili, A.K., Estes, A.M., Fang, X.R., Kanu, A., Gonzalez, F.J., Malik, K.U., Malik, K.U. Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F981-F992. >>> Angiotensin II; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (female, D57BL6 or Cyp1b1, 8 weeks old, 20-30g); cardiovascular; peptides; bp measured using tail cuff;.

14963 Hernanz, R., Martinez-Revelles, S., Palacios, R., Martin, A., Cachofeiro, V., Aguado, A., Garcia-Redondo, L., Barrus, M.T., de Batista, P.R., Briones, A.M., Salaices, M., Alonso, M.J., Alonso, M.J. Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):3159-3176. >>> Angiotensin II; SC; Mice; Animal info (male, C57BL6, 26.8g); cardiovascular; peptides; bp measured using tail cuff;.

14947 Gramlich, M., Pane, L.S., Zhou, Q.F., Chen, Z.F., Murgia, M., Schoetterl, S., Goedel, A., Metzger, K., Brade, T., Parrotta, E., Schaller, M., Gerull, B., Thierfelder, L., artsma-Rus, A., Labeit, S., Atherton, J.J., McGaughran, J., Harvey, R.P., Sinnecker, D., Mann, M., Laugwitz, K.L., Gawaz, M.P., Moretti, A., Gramlich, M. Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy. EMBO Molecular Medicine 2015; 7(--):562-576. >>> Angiotensin II; SC; Mice; Animal info (WT or HET); cardiovascular; peptides;.

14946 Govender, M.M., Nadar, A., Govender, M.M. A Subpressor Dose of Angiotensin II Elevates Blood Pressure in a Normotensive Rat Model by Oxidative Stress. PHYSIOLOGICAL RESEARCH 2015; 64(--):153-159. >>> Angiotensin II; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 150g); functionality of mp verified by plasma levels (subpressor dose); cardiovascular; peptides; bp measured using tail cuff;.

14943 Glenn, D.J., Cardema, M.C., Ni, W., Zhang, Y., Yeghiazarians, Y., Grapov, D., Fiehn, O., Gardner, D.G., Glenn, D.J. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H339-H350. >>> Angiotensin II; SC; Mice; 1002; Controls received mp w/ saline; animal info (DBA/2J, 12-14 weeks old); cardiovascular; peptides; bp measured by tail cuff;.

14944 Glass, M.J., Wang, G., Coleman, C.G., Chan, J., Ogorodnik, E., Van Kempen, T.A., Milner, T.A., Butler, S.D., Young, C.N., Davisson, R.L., Iadecola, C., Pickel, V.M., Glass, M.J. NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II. JOURNAL OF NEUROSCIENCE 2015; 35(--):9558-9567. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (male, WT or fGluN1, 4-5 months old); cardiovascular; peptides;.

14939 Garcia-Tejedor, A., Castello-Ruiz, M., Gimeno-Alcaniz, J.V., Manzanares, P., Salom, J.B., Salom, J.B. In vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I-and angiotensin II-induced hypertension in Wistar rats. JOURNAL OF FUNCTIONAL FOODS 2015; 15(--):294-300. >>> Angiotensin I; angiotensin II; Water, distilled; acetic acid; SC; Rat; 2ML4; Controls received mp w/ saline; animal info (male, Wistar, 200-225g); cardiovascular; peptides; bp measured using tail cuff; pumps removed after 28 days;.

14937 Gao, D.F., Hao, G.H., Meng, Z., Ning, N., Yang, G., Liu, Z.W., Dong, X., Niu, X.L., Gao, D.F. Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells. PLoS One 2015; 10(--):U640-U659. >>> Angiotensin II; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-220g); cardiovascular; peptides; bp measured using tail cuff;.

14933 Frenay, A.R.S., Yazdani, S., Boersema, M., van der Graaf, A.M., Waanders, F., van den Born, J., Navis, G.J., van Goor, H., van Goor, H. Incomplete Restoration of Angiotensin II - Induced Renal Extracellular Matrix Deposition and Inflammation Despite Complete Functional Recovery in Rats. PLoS One 2015; 10(--):U2782-U2800. >>> Angiotensin II; NaCl; IP; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 240-280g); post op. care (recovered at 37C in ventilated incubator, buprenorphine 50 ug/kg); cardiovascular; peptides; pumps removed after 3 weeks;.

14927 Escudero, P., Navarro, A., Ferrando, C., Furio, E., Gonzalez-Navarro, H., Juez, M., Sanz, M.J., Piqueras, L., Piqueras, L. Combined treatment with bexarotene and rosuvastatin reduces angiotensin-II-induced abdominal aortic aneurysm in apoE(-/-) mice and angiogenesis. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):2946-2960. >>> Angiotensin II; Saline; Mice; 2004; Controls received mp w/ vehicle; animal info (apoE -/-, 8 weeks old); cardiovascular; peptides;“Because the s.c. administration of the statin using an osmotic minipump allows 100% drug bioavailability and its p.o. administration results in 34.5% bioavailability in mice (Peng et al., 2009), we chose the former route to ensure a full dosage effect.” pg 2948;.

14919 Eberson, L.S., Sanchez, P.A., Majeed, B.A., Tawinwung, S., Secomb, T.W., Larson, D.F., Larson, D.F. Effect of Lysyl Oxidase Inhibition on Angiotensin II-Induced Arterial Hypertension, Remodeling, and Stiffness. PLoS One 2015; 10(--):U3755-U3770. >>> Angiotensin II, [Val5]; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 3 months old); cardiovascular; peptides; pumps removed after 14 days; bp measured using tail cuff;.

14925 Drenckhahn, J.D., Strasen, J., Heinecke, K., Langner, P., Yin, K.V., Skole, F., Hennig, M., Spallek, B., Fischer, R., Blaschke, F., Heuser, A., Cox, T.C., Black, M.J., Thierfelder, L., Drenckhahn, J.D. Impaired myocardial development resulting in neonatal cardiac hypoplasia alters postnatal growth and stress response in the heart. CARDIOVASCULAR RESEARCH 2015; 106(--):43-54. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 1002; 2002; Controls received mp w/ vehicle; animal info (Hccs KO, 10 weeks old); cardiovascular; peptides;.

14920 Dimke, H., Sparks, M.A., Thomson, B.R., Frische, S., Coffman, T.M., Quaggin, S.E., Quaggin, S.E. Tubulovascular Cross-Talk by Vascular Endothelial Growth Factor A Maintains Peritubular Microvasculature in Kidney. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1027-1038. >>> Angiotensin II; SC; Mice; Animal info (male, Vegfa tub, 8-12 weeks old); cardiovascular; peptides; bp measured using radiotelemetry;.

14900 Cunningham, MW Jr, West, C.A., Wen, X.R., Deng, A.H., Baylis, C., Cunningham, MW Jr  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 308(--):R945-R956. >>> Angiotensin II; tumor necrosis factor, alpha; SC; Rat (pregnant); 2ML2; Controls received mp w/ saline; animal info (female, Sprague Dawley, 15-21 weeks, day 6 of pregnancy); cardiovascular; peptides;.

14894 Choi, S.Y., Ryu, Y., Kee, H.J., Cho, S.N., Kim, G.R., Cho, J.Y., Kim, H.S., Kim, I.K., Jeong, M.H., Kee, H.J. Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes. VASCULAR PHARMACOLOGY 2015; 72(--):130-140. >>> Angiotensin II; Mice; Controls received mp w/ saline; animal info (male, ICR, 30g); cardiovascular; peptides;.

14880 Chen, G., Cao, Q., Cui, X.L., Pan, S.F., Shen, C., Liu, L.H., Liu, L.H. Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 2015; 18(--):235-248. >>> Angiotensin II; PBS; acetic acid; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6J, 19-21g); cardiovascular; peptides;.

14876 Cheang, W.S., Ngai, C.Y., Tam, Y.Y., Tian, X.Y., Wong, W.T., Zhang, Y., Lau, C.W., Chen, Z.Y., Bian, Z.X., Huang, Y., Leung, F.P., Huang, Y. Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress. SCIENTIFIC REPORTS 2015; 5(--):U1-U10. >>> Angiotensin II; Saline; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-260g); cardiovascular; peptides; bp measured using in tail cuff;.

14874 Chang, K.H., Nayak, R.C., Roy, S., Perumbeti, A., Wellendorf, A.M., Bezold, K.Y., Pirman, M., Hill, S.E., Starnes, J., Loberg, A., Zhou, X., Inagami, T., Zheng, Y., Malik, P., Cancelas, J.A., Malik, P. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT(2)R and cytoskeletal dysregulation. Nature Communications 2015; 6(--):U16-U26. >>> Angiotensin II; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (C57BL6 or AT1R KO, 6-20 weeks old); functionality of mp verified by plasma concentration; cardiovascular; peptides;.

14867 Carver, K.A., Smith, T.L., Gallagher, P.E., Tallant, E.A., Tallant, E.A. Angiotensin-(1-7) Prevents Angiotensin II-induced Fibrosis in Cremaster Microvessels. MICROCIRCULATION 2015; 22(--):19-27. >>> Angiotensin II; angiotensin (1-7); SC; Rat; 2ML4; Controls received sham surgery; animal info (male, Lewis, 4 weeks old); no stress (see pg. 21); cardiovascular; peptides; bp measured using tail cuff;.

14866 Carroll, M.A., Kang, Y., Chander, P.N., Stier, CT Jr, Carroll, M.A. Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels and Reduced Renovascular 20-HETE Levels. AMERICAN JOURNAL OF HYPERTENSION 2015; 28(--):664-671. >>> Angiotensin II; Acetic acid; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 175-200g, 6-7 weeks old); cardiovascular; peptides; bp measured using radiotelemetry (DSI);.

14856 Burillo, E., Lindholt, J.S., Molina-Sanchez, P., Jorge, I., Martinez-Pinna, R., Blanco-Colio, L.M., Tarin, C., Torres-Fonseca, M.M., Esteban, M., Laustsen, J., Ramos-Mozo, P., Calvo, E., Lopez, J.A., de Ceniga, M.V., Michel, J.B., Egido, J., Andres, V., Vazquez, J., Meilhac, O., Martin-Ventura, J.L., Martin-Ventura, J.L. ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression. THROMBOSIS AND HAEMOSTASIS 2015; 113(--):1335-1346. >>> Angiotensin II; SC; Mice; Animal info (ApoE -/-, 8 weeks old); cardiovascular; peptides;.

14842 Bihl, J.C., Zhang, C., Zhao, Y.H., Xiao, X., Ma, X.T., Chen, Y.S., Chen, S.Z., Zhao, B., Chen, Y.F., Bihl, J.C. Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the NFkappaB inflammatory pathway. VASCULAR PHARMACOLOGY 2015; 73(--):115-123. >>> Angiotensin II; angiotensin (1-7); A-779; IP; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6, 8-10 weeks old, 25-32g); ischemia (cerebral); behavioral testing (gait, circling/climbing behavior, body and front limb symmetry, compulsory circling); cardiovascular; peptides; bp measured using radiotelemetry (DSI); pumps primed for 48h at 37C sterile isotonic saline; used IP catheter;.

14846 Bhatta, A., Yao, L., Toque, H.A., Shatanawi, A., Xu, Z.M., Caldwell, R.B., Caldwell, R.W., Caldwell, R.W. Angiotensin II-Induced Arterial Thickening, Fibrosis and Stiffening Involves Elevated Arginase Function. PLoS One 2015; 10(--):U2637-U2656. >>> Angiotensin II; SC; Mice; 1004; Controls received mp w/ saline; animal info (ARG1 +/- or C57BL6J); cardiovascular; peptides;.

14812 Aguado, A., Rodriguez, C., Martinez-Revelles, S., Avendano, M.S., Zhenyukh, O., Orriols, M., Martinez-Gonzalez, J., Alonso, M.J., Briones, A.M., Dixon, D.A., Salaices, M., Salaices, M. HuR mediates the synergistic effects of angiotensin II and IL-1 on vascular COX-2 expression and cell migration. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):3028-3042. >>> Angiotensin II; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J); cardiovascular; peptides;.

14797 Ramseyer, V.D., Gonzalez-Vicente, A., Carretero, O.A., Garvin, J.L., Garvin, J.L. Angiotensin II-induced hypertension blunts thick ascending limb NO production by reducing NO synthase 3 expression and enhancing threonine 495 phosphorylation. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F149-F156. >>> Angiotensin II; Acetic acid; SC; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 90-120g); cardiovascular; peptides;.

14791 Qin, B., Zhou, J.L., Zhou, J.L. Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension. PLoS One 2015; 10(--):U2448-U2454. >>> Angiotensin II; PBS; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL, 8 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

14790 Qi, J., Yang, P., Yi, B., Huo, Y., Chen, M., Zhang, J., Sun, J.X., Sun, J.X. Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H841-H852. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (male, apoE -/-. 10 weeks old); cardiovascular; peptides;“Infusion of ANG II with subcutaneous osmotic minipumps in apolipoprotein E-null (apoE-/-) mice is a widely used mouse model of AAA, which exhibits multiple characteristics of human AAAs, including disruption of media, secretion of MMPs, rupture of elastic layer, macrophage infiltration, and neovascularization” pg H841; bp measured using tail cuff;.

14789 Zhao, N., Koenig, S.N., Trask, A.J., Lin, C.H., Hans, C.P., Garg, V., Lilly, B., Lilly, B. MicroRNA miR145 Regulates TGFBR2 Expression and Matrix Synthesis in Vascular Smooth Muscle Cells. CIRCULATION RESEARCH 2015; 116(--):23-U73. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (miR145 -/-, 20-24 weeks old); cardiovascular; peptides; pumps primed for 48 hours;.

14788 Zhao, Q.D., Viswanadhapalli, S., Williams, P., Shi, Q., Tan, C.Y., Yi, X.L., Bhandari, B., Abboud, H.E., Zhao, Q.D. NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFkappaB Signaling Pathways. CIRCULATION 2015; 131(--):643-U152. >>> Angiotensin II; Water; IP; Mice (transgenic); 1004; Controls received mp w/ vehicle; animal info (male, lox-stop-lox human Nox4 Tg, 16 weeks); no stress (see pg. 644); cardiovascular; peptides;.

14777 Zimmerman, M.A., Baban, B., Tipton, A.J., O'Connor, P.M., Sullivan, J.C., Sullivan, J.C. Chronic ANG II infusion induces sex-specific increases in renal T cells in Sprague-Dawley rats. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F706-F712. >>> Angiotensin II; A-779; SC; Rat; Controls received mp w/ vehicle; animal info (Sprague Dawley, 12 weeks old); cardiovascular; immunology; peptides; bp measured using radiotelemetry (DSI).

14770 Tan, R.J., Zhou, D., Xiao, L.X., Zhou, L.L., Li, Y.J., Bastacky, S.I., Oury, T.D., Liu, Y.H., Liu, Y.H. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):2447-2459. >>> Angiotensin II; SC; Mice; 2004; Animal info (nephrectomy, EC-SOD null); peptides.

14767 Van Kempen, T.A., Dodos, M., Woods, C., Marques-Lopes, J., Justice, N.J., Iadecola, C., Pickel, V.M., Glass, M.J., Milner, T.A., Glass, M.J. SEX DIFFERENCES IN NMDA GluN1 PLASTICITY IN ROSTRAL VENTROLATERAL MEDULLA NEURONS CONTAINING CORTICOTROPIN-RELEASING FACTOR TYPE 1 RECEPTOR FOLLOWING SLOW-PRESSOR ANGIOTENSIN II HYPERTENSION. NEUROSCIENCE 2015; 307(--):83-97. >>> Angiotensin II; Saline; albumin, bovine serum; SC; Mice; Control animals received mp w/vehicle; animal info (BAC transgenic, male, female, 2-3 mo old); peptides; systolic blood pressure measured via tail cuff.

14764 Wilson, P.C., Fitzgibbon, W.R., Garrett, S.M., Jaffa, A.A., Luttrell, L.M., Brands, M.W., El-Shewy, H.M., El-Shewy, H.M. Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. MOLECULAR ENDOCRINOLOGY 2015; 29(--):896-908. >>> Angiotensin II; Mice; 1002; animal info (10-12 wks old, male, SphK1 -/-, C57BL/6); peptides.

14761 Wang, T.N., Chen, X., Li, R.Z., Gao, B., Mohammed-Ali, Z., Lu, C., Yum, V., Dickhout, J.G., Krepinsky, J.C., Krepinsky, J.C. SREBP-1 Mediates Angiotensin II-Induced TGF-beta1 Upregulation and Glomerular Fibrosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1839-1854. >>> Angiotensin II; animal info (male, 129Sv/Ev, 7-8 wks old, nephrectomy); peptides; blood pressure measured via tail cuff.

14758 Accornero, F., van Berlo, J.H., Correll, R.N., Elrod, J.W., Sargent, M.A., York, A., Rabinowitz, J.E., Leask, A., Molkentin, J.D., Molkentin, J.D. Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor beta Signaling and Cardiac Remodeling. MOLECULAR AND CELLULAR BIOLOGY 2015; 35(--):2154-2164. >>> Angiotensin II; phenylephrine; Mice; Controls received mp w/ vehicle; animal info (Ctgf fl/fl); cardiovascular;.

14510 Yodoi, K., Yamashita, T., Sasaki, N., Kasahara, K., Emoto, T., Matsumoto, T., Kita, T., Sasaki, Y., Mizoguchi, T., Sparwasser, T., Hirata, K., Yamashita, T. Foxp3(+) Regulatory T Cells Play a Protective Role in Angiotensin II-Induced Aortic Aneurysm Formation in Mice. Hypertension 2015; 65(--):889-+. >>> Angiotensin II; Mice; Controls received mp w/ saline; animal info (male, ApoE -/-); cardiovascular; peptides;.

14503 Yao, Y., Norris, E.H., Strickland, S., Strickland, S. The cellular origin of laminin determines its role in blood pressure regulation. CELLULAR AND MOLECULAR LIFE SCIENCES 2015; 72(--):999-1008. >>> Angiotensin II; Mice; Controls received mp w/ saline; animal info (SKO, NKO or control, 2-4 months old); no stress (see pg. 1003); cardiovascular; peptides; bp measured using tail cuff;.

14498 Yan, M.W., Chen, C., Gong, W., Yin, Z.W., Zhou, L., Chaugai, S., Wang, D.W., Wang, D.W. miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8. Cardiovascular Research 2015; 105(--):340-352. >>> Angiotensin II; Saline; Mice; Controls received mp w/ vehicle; animal info (male C57BL6, 22-25g); cardiovascular; peptides; cardiac hypertrophy;.

14466 Wang, X., Berry, E., Hernandez-Anzaldo, S., Takawale, A., Kassiri, Z., Fernandez-Patron, C., Fernandez-Patron, C. Matrix Metalloproteinase-2 Mediates a Mechanism of Metabolic Cardioprotection Consisting of Negative Regulation of the Sterol Regulatory Element-Binding Protein-2/3-Hydroxy-3-Methylglutaryl-CoA Reductase Pathway in the Heart. Hypertension 2015; 65(--):882-+. >>> Angiotensin II; SC; Mice; Controls received mp w/ PBS; animal info (male, Mmp2 -/-, 11-14 weeks old); cardiovascular; peptides;.

14444 Trachet, B., Fraga-Silva, R.A., Piersigilli, A., Tedgui, A., Sordet-Dessimoz, J., Astolfo, A., Van der Donckt, C., Modregger, P., Stampanoni, M.F.M., Segers, P., Stergiopulos, N., Trachet, B. Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation. Cardiovascular Research 2015; 105(--):213-222. >>> Angiotensin II; Mice; 2004; Animal info (male C57BL6J, 12 weeks old); cardiovascular; peptides;.

14410 Song, J., Lu, Y., Lai, E.Y., Wei, J., Wang, L., Chandrashekar, K., Wang, S., Shen, C., Juncos, L.A., Liu, R., Liu, R. Oxidative status in the macula densa modulates tubuloglomerular feedback responsiveness in Angiotensin II-induced hypertension. ACTA PHYSIOLOGICA 2015; 213(--):249-258. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (C57BL6, 18-20g); cardiovascular; peptides; bp measured using radiotelemetry;.

14409 Snijder, P.M., Frenay, A.R., de Boer, R.A., Pasch, A., Hillebrands, J.L., Leuvenink, H.G.D., van Goor, H., van Goor, H. Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats. British Journal of Pharmacology 2015; 172(--):1494-1504. >>> Angiotensin II; SC; Rat; 2004; Controls received mp w/ NaCl; animal info (male, Sprague Dawley, 240-260g); post op. care (buprenorphine SC 50 ug/kg injection; 37C ventilated incubator); cardiovascular; peptides;.

14381 Saleh, M.A., McMaster, W.G., Wu, J., Norlander, A.E., Funt, S.A., Thabet, S.R., Kirabo, A., Xiao, L., Chen, W., Itani, H.A., Michell, D., Huan, T.X., Zhang, Y.H., Takaki, S., Titze, J., Levy, D., Harrison, D.G., Madhur, M.S., Madhur, M.S. Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. Journal of Clinical Investigation 2015; 125(--):1189-1202. >>> Angiotensin II; NaCl; acetic acid; SC; Mice; 2002; 2004; Controls received mp w/ vehicle; animal info (Lnk -/-, 10-12 weeks old); cardiovascular; immunology; peptides; bp measured using radiotelemetry or tail cuff;.

14368 Rivera-Torres, J., Guzman-Martinez, G., Villa-Bellosta, R., Orbe, J., Gonzalez-Gomez, C., Serrano, M., Diez, J., Andres, V., Maraver, A., Maraver, A. Targeting gamma-secretases protect against angiotensin II-induced cardiac hypertrophy. Journal of Hypertension 2015; 33(--):843-850. >>> Angiotensin II; SC; Mice (transgenic); 2004; Controls received mp w/ saline; animal info (male, Cre ERT2/ERT2, 8 weeks old); cardiovascular; peptides;.

14302 Meng, Y., Li, T., Zhou, G.S., Chen, Y., Yu, C.H., Pang, M.X., Li, W., Li, Y., Zhang, W.Y., Li, X., Li, X. The Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway. ANTIOXIDANTS&REDOX SIGNALING 2015; 22(--):241-258. >>> Angiotensin II; angiotensin (1-7); SC; Rat; 2004; 2ML4; Controls received mp w/ saline; animal info (male, Wisstar, 200-300g); cardiovascular; peptides;.

14263 Lee, S., Kim, I.K., Ahn, J.S., Woo, D.C., Kim, S.T., Song, S., Koh, G.Y., Kim, H.S., Jeon, B.H., Kim, I., Kim, I. Deficiency of Endothelium-Specific Transcription Factor Sox17 Induces Intracranial Aneurysm. Circulation 2015; 131(--):995-+. >>> Angiotensin II; SC; Mice; Animal info (Sox17 fl/fl);cardiovascular; peptides;.

14239 Khan, N.S., Song, C.Y., Jennings, B.L., Estes, A.M., Fang, X.R., Bonventre, J.V., Malik, K.U., Malik, K.U. Cytosolic Phospholipase A(2)alpha Is Critical for Angiotensin II-Induced Hypertension and Associated Cardiovascular Pathophysiology. Hypertension 2015; 65(--):784-+. >>> Angiotensin II; Saline; Mice; Controls received mp w/ vehicle; animal info (cPLA2a +/+); cardiovascular; peptides; bp measured using tail cuff and telemetry;.

14235 Kamat, N.V., Thabet, S.R., Xiao, L., Saleh, M.A., Kirabo, A., Madhur, M.S., Delpire, E., Harrison, D.G., McDonough, A.A., McDonough, A.A. Renal Transporter Activation During Angiotensin-II Hypertension is Blunted in Interferon-gamma(-/-) and Interleukin-17A(-/-) Mice. Hypertension 2015; 65(--):569-U169. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (C57BL6J or IFN-g -/-); cardiovascular; peptides; bp measured using radiotelemetry;.

14234 Kadoguchi, T., Kinugawa, S., Takada, S., Fukushima, A., Furihata, T., Homma, T., Masaki, Y., Mizushima, W., Nishikawa, M., Takahashi, M., Yokota, T., Matsushima, S., Okita, K., Tsutsui, H., Kinugawa, S. Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle. Experimental Physiology 2015; 100(--):312-322. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 10-12 wekks old); behavioral testing (treadmill testing); cardiovascular; peptides; bp measured using tail cuff;.

14220 Honjo, T., Chyu, K.Y., Dimayuga, P.C., Yano, J.L., Lio, W.M., Trinidad, P., Zhao, X.N., Zhou, J.C., Chen, S., Cercek, B., Arditi, M., Shah, P.K., Shah, P.K. ApoB-100-Related Peptide Vaccine Protects Against Angiotensin II-Induced Aortic Aneurysm Formation and Rupture. Journal of the American College of Cardiology 2015; 65(--):546-556. >>> Angiotensin II; SC; Mice; Animal info (male, ApoE -/-, 10 weeks old); cardiovascular; immunology; peptides;.

14214 He, Z.W., Zhang, X., Chen, C., Wen, Z., Hoopes, S.L., Zeldin, D.C., Wang, D.W., Wang, D.W. Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II. Cardiovascular Research 2015; 105(--):304-317. >>> Angiotensin II; Mice (transgenic); 1002; Controls received mp w/ saline; animal info (male, CYP2J2, 8 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

14750 Gonzalez, G.E., Rhaleb, N.E., D'Ambrosio, M.A., Nakagawa, P., Liu, Y.H., Leung, P., Dai, X.G., Yang, X.P., Peterson, E.L., Carretero, O.A., Carretero, O.A. Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension. Journal of Hypertension 2015; 33(--):144-152. >>> Angiotensin II; Saline; acetic acid; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J or IL-6 KO); long-term study; cardiovascular; peptides; bp measured using telemetry;.

14741 Gao, X., Yang, T., Liu, M., Peleli, M., Zollbrecht, C., Weitzberg, E., Lundberg, J.O., Persson, A.E.G., Carlstroem, M., Carlstroem, M. NADPH Oxidase in the Renal Microvasculature Is a Primary Target for Blood Pressure-Lowering Effects by Inorganic Nitrate and Nitrite. Hypertension 2015; 65(--):161-+. >>> Angiotensin II; SC; Rat; Animal info (male, Sprague Dawley); cardiovascular; peptides; bp measured using radiotelemetry;.

14732 Falkenham, A., de Antueno, R., Rosin, N., Betsch, D., Lee, T.D.G., Duncan, R., Legare, J.F., Legare, J.F. Nonclassical Resident Macrophages Are Important Determinants in the Development of Myocardial Fibrosis. American Journal of Pathology 2015; 185(--):927-942. >>> Angiotensin II; Saline; Mice; Controls received mp w/ vehicle; animal info (male, C57BL or Cx3crl -/-, 8-10 weeks old); cardiovascular; immunology; peptides; bp measured using tail cuff;.

14731 Escudero, P., de Maranon, A.M., Collado, A., Gonzalez-Navarro, H., Hermenegildo, C., Peiro, C., Piqueras, L., Sanz, M.J., Sanz, M.J. Combined Sub-Optimal Doses of Rosuvastatin and Bexarotene Impair Angiotensin II-Induced Arterial Mononuclear Cell Adhesion Through Inhibition of Nox5 Signaling Pathways and Increased RXR/PPARalpha and RXR/PPARgamma Interactions. ANTIOXIDANTS&REDOX SIGNALING 2015; 22(--):901-920. >>> Angiotensin II; rosu; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (C57BL6 or ApoE -/-, 23-30g); cardiovascular; peptides; antihypertensive;.

14725 Ehanire, T., Ren, L.C., Bond, J., Medina, M., Li, G., Bashirov, L., Chen, L., Kokosis, G., Ibrahim, M., Selim, A., Blobe, G.C., Levinson, H., Levinson, H. Angiotensin II stimulates canonical TGF-beta signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction. JOURNAL OF MOLECULAR MEDICINE-JMM 2015; 93(--):289-302. >>> Angiotensin II; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (AT1 KO or C57BL6J, 10-12 weeks old, 18-20g); cardiovascular; peptides;.

14723 Duerrschmid, C., Trial, J., Wang, Y.L., Entman, M.L., Haudek, S.B., Haudek, S.B. Tumor Necrosis Factor A Mechanistic Link Between Angiotensin-II-Induced Cardiac Inflammation and Fibrosis. Circulation-Heart Failure 2015; 8(--):352-+. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (TNFR1-KO, 8-10 weeks old); cardiovascular; peptides;.

14720 Dolinsky, V.W., Soltys, C.L.M., Rogan, K.J., Chan, A.Y.M., Nagendran, J., Wang, S., Dyck, J.R.B., Dyck, J.R.B. Resveratrol prevents pathological but not physiological cardiac hypertrophy. JOURNAL OF MOLECULAR MEDICINE-JMM 2015; 93(--):413-425. >>> Angiotensin II; SC; Mice; Animal info (C57BL6); cardiovascular; peptides;.

14719 Ding, Z.F., Liu, S.J., Wang, X.W., Khaidakov, M., Fan, Y.B., Deng, X.Y., Xiang, D., Mehta, J.L., Mehta, J.L. Lectin-like oxidized low-density lipoprotein receptor-1 regulates autophagy and Toll-like receptor 4 in the brain of hypertensive mice. Journal of Hypertension 2015; 33(--):525-533. >>> Angiotensin II; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (LOX-1 KO); cardiovascular; peptides; bp measured using radiotelemetry;.

14718 Dang, M.Q., Zhao, X.C., Lai, S., Wang, X., Wang, L., Zhang, Y.L., Liu, Y., Yu, X.H., Liu, Y., Li, H.H., Xia, Y.L., Xia, Y.L. Gene Expression Profile in the Early Stage of Angiotensin II-induced Cardiac Remodeling: a Time Series Microarray Study in a Mouse Model. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015; 35(--):467-476. >>> Angiotensin II; Ringer's solution; Mice; 1007D; Animal info (male, C57BL); cardiovascular; peptides; bp measured by tail cuff;.

14698 Cifuentes, D., Poittevin, M., Dere, E., Broqueres-You, D., Bonnin, P., Benessiano, J., Pocard, M., Mariani, J., Kubis, N., Merkulova-Rainon, T., Levy, B.I., Levy, B.I. Hypertension Accelerates the Progression of Alzheimer-Like Pathology in a Mouse Model of the Disease. Hypertension 2015; 65(--):218-+. >>> Angiotensin II; SC; Mice; 2006; Animal info (male, APPPS1 heterozygous, 7 weeks old); pumps replaced every 6 weeks; neurodegenerative (Alzheimer's disease); behavioral testing (memory test, locomotor activity; long-term study; cardiovascular; peptides; bp measured using tail cuff;.

14692 Chen, Z., Wen, L., Martin, M., Hsu, C.Y., Fang, L.H., Lin, F.M., Lin, T.Y., Geary, M.J., Geary, G.G., Zhao, Y.L., Johnson, D.A., Chen, J.W., Lin, S.J., Chien, S., Huang, H.D., Miller, Y.I., Huang, P.H., Shyy, J.Y.J., Shyy, J.Y.J. Oxidative Stress Activates Endothelial Innate Immunity via Sterol Regulatory Element Binding Protein 2 (SREBP2) Transactivation of MicroRNA-92a. Circulation 2015; 131(--):805-U125. >>> Angiotensin II; SC; Mice; 1004; Animal info (male, ApoE -/-); cardiovascular; peptides;.

14691 Chen, X.Q., Liu, X., Wang, Q.X., Zhang, M.J., Guo, M., Liu, F., Jiang, W.F., Zhou, L., Liu, X. Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-kappaB/TGF-beta1/TRIF/TRAF6 pathway. Experimental Cell Research 2015; 330(--):43-55. >>> Angiotensin II; SC; Mice; 1007D; Controls received mp w/ saline; animal info (male, C57BL6J, 6-8 weeks old); cardiovascular; peptides;.

14686 Chan, S.L., Umesalma, S., Baumbach, G.L., Baumbach, G.L. Epidermal Growth Factor Receptor Is Critical For Angiotensin II-Mediated Hypertrophy in Cerebral Arterioles. Hypertension 2015; 65(--):806-+. >>> Angiotensin II; Mice; 1004; Controls received mp w/ saline; animal info (Egfr wa2/J or WT); cardiovascular; peptides;.

14668 Berger, J.M., Vaillant, N., Le May, C., Calderon, C., Bregeon, J., Prieur, X., Hadchouel, J., Loirand, G., Cariou, B., Cariou, B. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. Atherosclerosis 2015; 239(--):252-259. >>> Angiotensin II; Saline; SC; Mice; 2004; Animal info (PCSK9 +/+ or PCSK9 -/-, male 10-11 or 30-32 weeks old, female 16-18 weeks old); cardiovascular; peptides; bp measured using radiotelemetry (DSI);.

14606 Dolber, P.C., Jin, H.X., Nassar, R., Coffman, T.M., Gurley, S.B., Fraser, M.O., Dolber, P.C. The Effects of Ins2(Akita) Diabetes and Chronic Angiotensin II Infusion on Cystometric Properties in Mice. NEUROUROLOGY AND URODYNAMICS 2015; 34(--):72-78. >>> Angiotensin II; Saline; SC; Mice; 2004; Control animals received mp w/ vehicle; animal infos (C57BL/6, STZ induced diabetes, 16 wks old); peptides; post op care (local anesthetic cream).

 

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“In order to investigate the in vivo role of MMPs, we established a rodent model of glioma progression... We chose continuous infusion using an osmotic pump as the method for delivering TIMP into the tumor. This paradigm allowed aggressive glioma development and circumvented the problem of the blood brain barrier disturbing reagent delivery following intravenous delivery.” Takahashi et al., Pharmacological Research 2002;46(2):155-163.