References on the Administration of Aldosterone Using ALZET® Osmotic Pumps

16336 Feldman, R. D., Ding, Q., Hussain, Y., Limbird, L. E., Pickering, J. G., Gros, R. Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER). FASEB J 2016; 30(-6-):2086-96. >>> Aldosterone; G protein-coupled estrogen receptor 15 antagonist; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (BALB/c male mice, 2 month old); cancer (Orthotopic renal cancer); dose-response (pg. 2093); Dose (200 ug/kg/day for both);.

16205 Lv, Y., Bai, S., Zhang, H., Zhang, H., Meng, J., Li, L., Xu, Y. Aldosterone down-regulates the slowly activated delayed rectifier potassium current in adult guinea pig cardiomyocytes. British Journal of Pharmacology 2015; 172(-23-):. >>> Aldosterone; PEG-400; SC; Guinea pig; 2004; Controls received mp w/ vehicle; animal info: Male adult guinea pigs weighing 200–250 g; functionality of mp verified by recording action potentials in papillary muscles and IKs in ventricular cardiomyocytes; cardiovascular; ECG used for electrophysiological recordings; Dose: 1 ug/hr.

16177 Shi, H., Zhang, A., He, Y., Yang, M., Gan, W. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Mol Med Rep 2016; 13(-6-):5102-8. >>> Aldosterone; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley,260-290g); cardiovascular; bp measured using tail cuff; Dose (0.75 ug/h);.

16176 Sheng, L., Yang, M., Ding, W., Zhang, M., Niu, J., Qiao, Z., Gu, Y. Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney. Exp Cell Res 2016; 346(-1-):99-110. >>> Aldosterone; Ethanol; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 18-200g); cardiovascular; Dose (0.75 ug/hr);.

16167 Sakamoto, T., Fujii, A., Saito, N., Kondo, H., Ohuchi, A. Alteration of amiloride-sensitive salt taste nerve responses in aldosterone/NaCl-induced hypertensive rats. Neurosci Res 2016; 108(--):60-6. >>> Aldosterone; Ethanol; propylene glycol; water; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 4 week old, 130-150g); 9% ethanol used; 87% propylene glycol; cardiovascular; bp measured using tail cuff; Dose (0.75 ug/h);.

16096 Bernardi, S., Toffoli, B., Zennaro, C., Bossi, F., Losurdo, P., Michelli, A., Carretta, R., Mulatero, P., Fallo, F., Veglio, F., Fabris, B. Aldosterone effects on glomerular structure and function. J Renin Angiotensin Aldosterone Syst 2015; 16(-4-):730-8. >>> Aldosterone; Eplerenone; NaCl; SC; rat; 2004; 2ML4; Controls received mp w/ vehicle, Harlan Teklad 18% Protein Global Diet; animal info: wild-type male Wistar rats, weighing 250 g; functionality of mp verified by: systolic blood pressure (SBP) via tail cuff plethysmography; post op. care (buprenorphine); injected SC 0.05 mg/kg day of; 0.025 mg/kg day after; cardiovascular; cardiovascular; Dose: aldosterone -- 72Ǩg/kg/day; eplerenone -- 100 mg/kg/day.

16055 Wang, B., Xu, X., He, X., Wang, Z., Yang, M. Berberine Improved Aldo-Induced Podocyte Injury via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress Pathways both In Vivo and In Vitro. Cell Physiol Biochem 2016; 39(-1-):217-28. >>> Aldosterone; SC; Rat; 2004; Controls received no mp; animal info (male, Sprague Dawley, 5-6 weeks old, 260-290g); functionality of mp verified by measuring urinary aldosterone levels (pg 220); cardiovascular; bp measured using tail cuff; Dose (0.75 ug/hr);.

15836 H.-W. WANG,y B. S. HUANG, y A. CHEN, M. AHMAD,, R. A. WHITE AND F. H. H. LEENEN  Neuroscience 2016; 314(--):90-105. >>> Aldosterone; eplerenone; FAD286; CSF, artificial; acetonitrile; SC; CSF/CNS; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250g); 4% acetonitrile used; Multiple pumps per animal; cardiovascular; bp measured using radiotelemetry; bp measured using radiotelemetry; dose (1.5 and 7.5 ug/kg/hr Aldosterone, 5ug/day Eplerenone, 25 ug/day FAD286).

15833 María Valero-Muñoz, PhD; Shanpeng Li, BS; Richard M. Wilson, BS; Maarten Hulsmans, PhD;, Tamar Aprahamian, PhD; JoséJ. Fuster, PhD; Matthias Nahrendorf, MD, PhD;, Philipp E. Scherer, PhD; Flora Sam, MD  Circ Heart Fail 2016; 9(--):1-10. >>> Aldosterone, D-; Saline; SC; Mice; Controls received mp w/ saline; animal info (C57BL6, 8 weeks old, 20-25g, uninephrectomy); replacement therapy (uninephrectomy); cardiovascular; bp measured using tail cuff; Dose (0.3 ug/h);.

15826 Andrew S. Terker, Chong Zhang, Kayla J. Erspamer, Gerardo Gamba, Chao-Ling Yang, David H. Ellison  Kidney Int 2016; 89(--):127-134. >>> Aldosterone; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (C57BL6 WT or BALB/c, 12-24 weeks old); 240 ug/kr/day.

15220 Koneru, B., Bathina, C.S., Cherry, B.H., Mifflin, S.W. Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2014; 306(-1-):R61-R66. >>> Aldosterone; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Animal info (Wistar-Kyoto, 275g); tissue perfusion (fourth ventricle); cardiovascular;.

15206 Clayton, S.C., Zhang, Z.M., Beltz, T., Xue, B.J., Johnson, A.K., Johnson, A.K. CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone1523. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2014; 306(--):R908-R917. >>> Angiotensin II; aldosterone; CSF, artificial; SC; CSF/CNS; Rat; 2001; .

15174 Zhang, Y., Robson, S.C., Morris, K.L., Heiney, K.M., Dwyer, K.M., Kishore, B.K., Ecelbarger, C.M., Kishore, B.K. Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F1398-F1408. >>> Aldosterone; SC; Mice; 1002; Animal info (hCD39, 2-4 months old);.

15114 Thunhorst, R.L., Xue, B.J., Beltz, T.G., Johnson, A.K., Thunhorst, R.L. Age-related changes in thirst, salt appetite, and arterial blood pressure in response to aldosterone-dexamethasone combination in rats. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 308(--):R807-R815. >>> Aldosterone; dexamethasome; SC; Rat; 2002; Animal info (male, Brown Norway, 3 or 11 or 28-29 months old); cardiovascular; for combined treatment, drugs delivered in same minipump; bp measured using radiotelemetry (DSI);.

15070 Sawada, H., Naito, Y., Oboshi, M., Iwasaku, T., Okuhara, Y., Morisawa, D., Eguchi, A., Hirotani, S., Masuyama, T., Naito, Y. Iron restriction inhibits renal injury in aldosterone/salt-induced hypertensive mice. HYPERTENSION RESEARCH 2015; 38(--):317-322. >>> Aldosterone; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8 weeks old, 20-23g); replacement therapy (uninephrectomy); cardiovascular; bp measured using tail cuff;.

15035 Martinez-Martinez, E., Cachofeiro, V., Rousseau, E., Alvarez, V., Calvier, L., Fernandez-Celis, A., Leroy, C., Miana, M., Jurado-Lopez, R., Briones, A.M., Jaisser, F., Zannad, F., Rossignol, P., Lopez-Andres, N., Lopez-Andres, N. Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2015; 411(--):20-27. >>> Aldosterone; NaCl; ethanol; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6, adult); 5% ethanol used; functionality of mp verified by plasma levels; cardiovascular; bp measured by tail cuff; 1 mg/kg/day.

15017 Ding, W., Xu, C.Y., Wang, B., Zhang, M.M., Zhang, M.M. Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. MEDICAL SCIENCE MONITOR 2015; 21(--):U1-U8. >>> Aldosterone; Ethanol; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 220-250g); 0.5% ethanol used; replacement therapy (uninephrectomy); cardiovascular; immunology;.

14973 Ichikawa, D., Kamijo-Ikemori, A., Sugaya, T., Shibagaki, Y., Yasuda, T., Hoshino, S., Katayama, K., Igarashi-Migitaka, J., Hirata, K., Kimura, K., Kamijo-Ikemori, A. Human liver-type fatty acid-binding protein protects against tubulointerstitial injury in aldosterone-induced renal injury. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F114-F121. >>> Aldosterone; PEG 300; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, hL-FABP Tg-Aldo, 8-10 weeks old, 27.5g); cardiovascular; bp measured using tail-cuff; dose: 0.125 ug/kg/min.

14502 Yang, M., Wang, B., Li, M., Jiang, B., Yang, M. Connexin 43 is Involved in Aldosterone-Induced Podocyte Injury. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2014; 34(--):1652-1662. >>> Aldosterone; SC; Rat; 2004; Controls received no mp; animal info (male, Sprague Dawley, 260-290g); cardiovascular; bp measured using tail cuff;.

14460 Wang, B., Ding, W., Zhang, M.M., Li, H.M., Gu, Y., Gu, Y. Rapamycin Attenuates Aldosterone-Induced Tubulointerstitial Inflammation and Fibrosis. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015; 35(--):116-125. >>> Aldosterone; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (Sprague Dawley); replacement therapy (uninephrectomized); cardiovascular;.

14431 Tanaka, K., Wilson, R.M., Essick, E.E., Duffen, J.L., Scherer, P.E., Ouchi, N., Sam, F., Sam, F. Effects of Adiponectin on Calcium-Handling Proteins in Heart Failure With Preserved Ejection Fraction. Circulation-Heart Failure 2014; 7(--):976-U166. >>> Aldosterone, D-; IP; Mice; Controls received mp w/ saline; animal info (APNTG, 12 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

14357 Queisser, N., Oteiza, P.I., Link, S., Hey, V., Stopper, H., Schupp, N., Queisser, N. Aldosterone Activates Transcription Factor Nrf2 in Kidney Cells Both In Vitro and In Vivo. ANTIOXIDANTS&REDOX SIGNALING 2014; 21(--):2126-2142. >>> Aldosterone; Rat; 2ML4; Controls received mp w/ PBS; animal info (male, Sprague Dawley, 5-6 weeks); cardiovascular;.

14356 Queisser, N., Happ, K., Link, S., Jahn, D., Zimnol, A., Geier, A., Schupp, N., Schupp, N. Aldosterone induces fibrosis, oxidative stress and DNA damage in livers of male rats independent of blood pressure changes. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 280(--):399-407. >>> Aldosterone; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley RjHan:SD, 5-6 weeks old); toxicology; cardiovascular; bp measured using tail cuff;.

14211 Gravez, B., Tarjus, A., Pelloux, V., Ouvrard-Pascaud, A., Delcayre, C., Samuel, J., Clement, K., Farman, N., Jaisser, F., Messaoudi, S., Messaoudi, S. Aldosterone Promotes Cardiac Endothelial Cell Proliferation In Vivo. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2015; 4(--):U351-U365. >>> Aldosterone; Ethanol; saline; Mice; Controls received mp w/ vehicle; animal info (male, B6D2, 4 months old); functionality of mp verified by plasma levels; 10% ethanol used; cardiovascular; bp measured using tail cuff;.

14695 Chrissobolis, S., Drummond, G.R., Faraci, F.M., Sobey, C.G., Chrissobolis, S. Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. Journal of Hypertension 2014; 32(--):1815-1821. >>> Aldosterone; Propylene glycol; ethanol; water; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, Nox2-/y or WT, 25 weeks or 70 weeks); functionality of mp verified by plasma levels; 9% ethanol used; 87% propylene glycol used; cardiovascular; bp measured using tail cuff;.

14581 Zhang, X.L., Liu, J., Pang, X.M., Zhao, J.J., Wang, S.Y., Wu, D., Liu, J. Aldosterone induces C-reactive protein expression via MR-ROS-MAPK-NF-kappaB signal pathway in rat vascular smooth muscle cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2014; 395(--):61-68. >>> Aldosterone; PEG400; SC; Rat; 2004; Control animals received mp w/ vehicle; animal info (male, Sprague Dawley, 180-220 g).

14574 Ohsawa, M., Tamura, K., Wakui, H., Maeda, A., Dejima, T., Kanaoka, T., Azushima, K., Uneda, K., Tsurumi-Ikeya, Y., Kobayashi, R., Matsuda, M., Uchida, S., Toya, Y., Kobori, H., Nishiyama, A., Yamashita, A., Ishikawa, Y., Umemura, S., Tamura, K. Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension. Kidney International 2014; 86(--):570-581. >>> Angiotensin II; aldosterone; SC; Mice; 2002; animal info (male, 11 wks old, ATRAP-KO, wt); peptides; blood pressure measured via radiotelemetry.

13869 Rock, M.L., Karas, A.Z., Rodriguez, K.B.G., Gallo, M.S., Pritchett-Corning, K., Karas, R.H., Aronovitz, M., Gaskill, B.N. The Time-to-Integrate-to-Nest Test as an Indicator of Wellbeing in Laboratory Mice. Journal of the American Association for Laboratory Animal Science 2014; 53(-1-):24-28. >>> Aldosterone; uridine, bromodeoxy-; Ethanol; saline; SC; Mice; Controls received mp w/ vehicle; animal info (10 mouse strains; BALB/cAnNCrl, 129S2/ SvPasCrl, FVB/NCrl, C57BL/6NCrl, C3H/HeNCrl, CB17/ Icr-Prkdcscid/IcrIcoCrl, NOD.CB17-Prkdcscid/NCrCrl, CB17.Cg/ Prkdcscid Lystbg/Crl, C57BL/6NTac, and C57BL/6NJ, carotid artery injury); 11% ethanol used; Multiple pumps per animal (2); post op. care (buprenorphine 0.05 mg/kg SC); behavioral testing (nesting behavoir); cardiovascular;.

13759 Doi, T., Doi, S., Nakashima, A., Ueno, T., Yokoyama, Y., Kohno, N., Masaki, T., Masaki, T. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats. PLoS One 2014; 9(--):U875-U881. >>> Aldosterone; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 220-250g, 6 weeks old); functionality of mp verified by increased bp; replacement therapy (uninephrectomy); immunology; bp measured using tail cuff; long-term study;.

13735 Cheema, M.U., Damkier, H.H., Nielsen, J., Poulsen, E.T., Enghild, J.J., Fenton, R.A., Praetorius, J., Praetorius, J. Distal Renal Tubules Are Deficient in Aggresome Formation and Autophagy upon Aldosterone Administration. PLoS One 2014; 9(--):U303-U315. >>> Aldosterone; SC; Rat; Animal info (male, Wistar); functionality of mp verified by blood plasma levels; immunology;.

13698 Kreusser, M.M., Lehmann, L.H., Riffel, J.H., Haass, M., Maser-Gluth, C., Backs, J., Katus, H.A., Buss, S.J., Kreusser, M.M. Aldosterone augments Na(+)-induced reduction of cardiac norepinephrine reuptake. American Journal of Physiology-Heart and Circulatory Physiology 2014; 307(--):H1169-H1177. >>> Aldosterone; Saline; SC; Rat; 2004; Control animals received mp w/ vehicle; animal info (male, Wistar).

13518 Zeniya, M., Sohara, E., Kita, S., Iwamoto, T., Susa, K., Mori, T., Oi, K., Chiga, M., Takahashi, D., Yang, S.S., Lin, S.H., Rai, T., Sasaki, S., Uchida, S. Dietary Salt Intake Regulates WNK3-SPAK-NKCC1 Phosphorylation Cascade in Mouse Aorta Through Angiotensin II. Hypertension 2013; 62(-5-):872-878. >>> Valsartan; angiotensin II; aldosterone; IP; Mice; Animal info (C57BL/6J. male); peptides.

13514 Hattori, T., Murase, T., Sugiura, Y., Nagasawa, K., Takahashi, K., Ohtake, M., Ohtake, M., Miyachi, M., Murohara, T., Nagata, K. Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury. HYPERTENSION RESEARCH 2014; 37(-2-):125-133. >>> Aldosterone, d-; Saline; ethanol; SC; Rat; 2004; Animal info (Sprague Dawley, uninephrectomized, 6 wks old, male, inbred); replacement therapy (uninephrectomy); 0.5% ethanol used.

13459 Salyer, S.A., Parks, J., Barati, M.T., Lederer, E.D., Clark, B.J., Klein, J.D., Khundmiri, S.J. Aldosterone regulates Na+, K+ ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2013; 1833(-10-):2143-2152. >>> Aldosterone; Rat; Controls received mp with vehicle or sham operated; animal info (male, Sprague Dawley, 100-150g); replacement therapy (adrenalectomy); immunology;.

13304 Xue, B.J., Zhang, Z.M., Beltz, T.G., Johnson, R.F., Guo, F., Hay, M., Johnson, A.K. Estrogen Receptor-beta in the Paraventricular Nucleus and Rostroventrolateral Medulla Plays an Essential Protective Role in Aldosterone/Salt-Induced Hypertension in Female Rats. Hypertension 2013; 61(-6-):1255-U261. >>> Propyl pyrazole triol; diarylpropionitrile; aldosterone; DMSO; saline; CSF/CNS; Rat; 2004; Cardiovascular; animal info (Sprague-Dawley, female, 10-12 wks old); DPN - selective ERb agonist, diaryl propionitrile, PPT- selective ERa agonist propyl-pyrazole-triol; 10% DMSO used.

13152 Jin, H.M., Zhou, D.C., Gu, H.F., Qiao, Q.Y., Fu, S.K., Liu, X.L., Pan, Y. Antioxidant N-Acetylcysteine Protects Pancreatic beta-Cells Against Aldosterone-Induced Oxidative Stress and Apoptosis in Female db/db Mice and Insulin-Producing MIN6 Cells. Endocrinology 2013; 154(-11-):4068-4077. >>> Aldosterone; SC; Mice; 2ML4; Animal info (C57BLKS/J, db/db, female, 8 wks old); long-term study; diabetes;.

13145 Nitta, E., Hirooka, K., Tenkumo, K., Fujita, T., Nishiyama, A., Nakamura, T., Itano, T., Shiraga, F. Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma. Cell Death&Disease 2013; 4(-;-):U109-U114. >>> Aldosterone; DMSO; SC; Rat; 2006; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 200-250 g); up to 5% DMSO used; long-term study;.

13121 Xue, B.J., Zhang, Z.M., Roncari, C.F., Guo, F., Johnson, A.K. Aldosterone Acting Through the Central Nervous System Sensitizes Angiotensin II-Induced Hypertension. Hypertension 2012; 60(-4-):1023-U482. >>> Angiotensin II; aldosterone; SC; CSF/CNS; Rat; 2001; 2002; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 10-12 wks old); peptides; multiple pumps used (2).

13119 van der Lubbe, N., Jansen, P.M., Salih, M., Fenton, R.A., van den Meiracker, A.H., Danser, A.H.J., Zietse, R., Hoorn, E.J. The Phosphorylated Sodium Chloride Cotransporter in Urinary Exosomes Is Superior to Prostasin as a Marker for Aldosteronism. Hypertension 2012; 60(-3-):741-U315. >>> Aldosterone; SC; Rat; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 15 wks old); replacement therapy (adrenalectomy).

13111 Ko, B., Mistry, A.C., Hanson, L., Mallick, R., Wynne, B.M., Thai, T.L., Bailey, J.L., Klein, J.D., Hoover, R.S. Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway. American Journal of Physiology-Renal Physiology 2013; 305(-5-):F645-F652. >>> Aldosterone; DMSO; SC; Rat; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 235-270 g); 25% DMSO used.

13085 Kusunoki, H., Taniyama, Y., Rakugi, H., Morishita, R. Cardiac and Renal Protective Effects of Irbesartan via Peroxisome Proliferator-Activated Receptorgamma-Hepatocyte Growth Factor Pathway Independent of Angiotensin II Type 1a Receptor Blockade in Mouse Model of Salt-Sensitive Hypertension. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2013; 2(-2-):U262-U273. >>> Aldosterone; SC; Mice; 1002; Animal info (8 wks old, AT1aRKO).

13080 McGraw, A.P., Bagley, J., Chen, W.S., Galayda, C., Nickerson, H., Armani, A., Caprio, M., Carmeliet, P., Jaffe, I.Z. Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor-Dependent Mechanism. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2013; 2(-1-):U658-U670. >>> Aldosterone; Saline; ethanol; Mice; 1004; Control animals received mp w/ vehicle; animal info (ApoE -/-, PIGF +/-, ApoE -/-, PIGF -/-, 9 wks old); post op care (buprenorphine); pumps replaced after 4 weeks; long-term study.

13030 Nishioka, T., Suzuki, M., Onishi, K., Takakura, N., inada, h, Yoshida, T., Hiroe, M., imanaka-yishida, k  J Cardiovasc. Pharmacol 2007; 49(-;-):261-268. >>> Angiotensin II; aldosterone; NaCl; acetic acid; SC; Mice; 1002; Control animals received mp w/ vehicle; animal info (BALB/c, female, 7 wks old); pumps replaced every 2 weeks.

13021 Bay-Richter, C., Hallberg, L., Ventorp, F., Janelidze, S., Brundin, L. Aldosterone synergizes with peripheral inflammation to induce brain IL-1beta expression and depressive-like effects. Cytokine 2012; 60(-3-):749-754. >>> Aldosterone; Ethanol; saline; SC; Rat; 2002; Control animals received mp w/ vehicle; animal info (Wistar, male, 200-250 g); post op. care (xylocain); 1% ethanol used.

12895 Messaoudi, S., Gravez, B., Tarjus, A., Pelloux, V., Ouvrard-Pascaud, A., Delcayre, C., Samuel, J., Launay, J.M., Sierra-Ramos, C., de la Rosa, D.A., Clement, K., Farman, N., Jaisser, F. Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo. Hypertension 2013; 61(-2-):361-U305. >>> Aldosterone; Mice; Animal info (MR Cardio, 4 mo old, males).

12886 Queisser, N., Amann, K., Hey, V., Habib, S.L., Schupp, N. Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo. Free Radical Biology and Medicine 2013; 54(-;-):17-25. >>> Aldosterone; NaCl; Rat; 2ML4; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 5-6 wks old).

12816 Calvier, L., Miana, M., Reboul, P., Cachofeiro, V., Martinez-Martinez, E., de Boer, R.A., Poirier, F., Lacolley, P., Zannad, F., Rossignol, P., Lopez-Andres, N. Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2013; 33(-1-):67-U221. >>> Aldosterone; NaCl; ethanol; Mice; Control animals received mp w/ vehicle; animal info (wt, Gal-3 KO); 5% ethanol used.

12800 Formenti, S., Bassi, M., Nakamura, N.B., Schoorlemmer, G.H.M., Menani, J.V., Colombari, E. Hindbrain mineralocorticoid mechanisms on sodium appetite. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2013; 304(-3-):R252-R259. >>> Aldosterone; Saline; ethanol; CSF/CNS; CSF/CNS (fourth ventricle); Rat; 2001; Control animals received mp w/ vehicle; animal info (Wistar Hannover, male, 280-350 g); guide cannula used; infusion rate incorrectly listed as 2 ul/hr; 1% ethanol used; dose response (table 1);.

12794 Patel, A.B., Frindt, G., Palmer, L.G. Feedback inhibition of ENaC during acute sodium loading in vivo. American Journal of Physiology-Renal Physiology 2013; 304(-2-):F222-F232. >>> Aldosterone; amiloride; PEG 300; SC; Rat; 2002; Animal info (Sprague Dawley, female, wks old, 200-300 g).

12759 Ronzaud, C., Loffing-Cueni, D., Hausel, P., Debonneville, A., Malsure, S.R., Fowler-Jaeger, N., Boase, N.A., Perrier, R., Maillard, M., Yang, B.L., Stokes, J.B., Koesters, R., Kumar, S., Hummler, E., Loffing, J., Staub, O. Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. Journal of Clinical Investigation 2013; 123(-2-):657-665. >>> Aldosterone; SC; Mice; 1003D; Control animals received mp w/ vehicle; animal info (Nedd4L Pax8/LC1 KO).

12696 McCurley, A., Pires, P.W., Bender, S.B., Aronovitz, M., Zhao, M.J., Metzger, D., Chambon, P., Hill, M.A., Dorrance, A.M., Mendelsohn, M.E., Jaffe, I.Z. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nature Medicine 2012; 18(-9-):1429-U182. >>> Aldosterone; angiotensin II; Mice; Animal info (MR KO); peptides.

12679 Yuan, Y.G., Huang, S.M., Wang, W.Y., Wang, Y.Y., Zhang, P., Zhu, C.H., Ding, G.X., Liu, B.C., Yang, T.X., Zhang, A.H. Activation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Kidney International 2012; 82(-7-):771-789. >>> Aldosterone; SC; Mice; Animal info (C57BL/6, 25-30 g, 8 wks old); functionality of mp verified via plasma drug levels.

12658 Veitenheimer, B.J., Engeland, W.C., Guzman, P.A., Fink, G.D., Osborn, J.W. Effect of global and regional sympathetic blockade on arterial pressure during water deprivation in conscious rats. American Journal of Physiology-Heart and Circulatory Physiology 2012; 303(-8-):H1022-H1034. >>> Aldosterone; Propylene glycol; SC; Rat; 2002; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male); replacement therapy (adrenolectomy).

12592 Uchimura, K., Kakizoe, Y., Onoue, T., Hayata, M., Morinaga, J., Yamazoe, R., Ueda, M., Mizumoto, T., Adachi, M., Miyoshi, T., Shiraishi, N., Sakai, Y., Tomita, K., Kitamura, K. In vivo contribution of serine proteases to the proteolytic activation of gammaENaC in aldosterone-infused rats. American Journal of Physiology-Renal Physiology 2012; 303(-7-):F939-F943. >>> Aldosterone; DMSO; saline, isotonic; SC; Rat; 2002; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, wks old, 160-170 g).

12591 Garcia, A.G., Wilson, R.M., Heo, J., Murthy, N.R., Baid, S., Ouchi, N., Sam, F. Interferon-gamma ablation exacerbates myocardial hypertrophy in diastolic heart failure. American Journal of Physiology-Heart and Circulatory Physiology 2012; 303(-5-):H587-H596. >>> Aldosterone, d-; Mice; Control animals received mp w/ saline; animal info (IFN-gamma KO, 12 wks old, male, 25-27 g); replacement therapy (uniphrectomy); 4-week pump used.

12530 Huang, B.S., Zheng, H., Tan, J.H., Patel, K.P., Leenen, F.H.H. Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Experimental Physiology 2011; 96(-10-):1028-1038. >>> Aldosterone; benzamil; Digibind; Propylene glycol; CSF, artificial; CSF/CNS; Rat; 2ML2; Controls received mp w/ vehicle; animal info (Wistar, male, 200 g).

12520 Deshmukh, P.A., Bellary, S.R., Schwender, F.T., Kamalov, G., Magotra, M., Curry, A.L.D., Sun, Y., Weber, K.T. Spironolactone Prevents the Inducibility of Ventricular Tachyarrhythmia in Rats With Aldosteronism. Journal of Cardiovascular Pharmacology 2011; 58(-5-):487-491. >>> Aldosterone; SC; Rat; Animal info (Sprague Dawley, male, 8 wks old); replacement therapy (uniphrectomy);.

12471 Ogawa, Y., Mukoyama, M., Yokoi, H., Kasahara, M., Mori, K., Kato, Y., Kuwabara, T., Imamaki, H., Kawanishi, T., Koga, K., Ishii, A., Tokudome, T., Kishimoto, I., Sugawara, A., Nakao, K. Natriuretic Peptide Receptor Guanylyl Cyclase-A Protects Podocytes from Aldosterone-Induced Glomerular Injury. Journal of the American Society of Nephrology 2012; 23(-7-):1198-1209. >>> Aldosterone; Ethanol; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, GC-A KO, 28 g); replacement therapy (uniphrectomized); 2% ethanol used.

12440 Andres, N.L., Tesse, A., Regnault, V., Louis, H., Cattan, V., Thornton, S.N., Labat, C., Kakou, A., Tual-Chalot, S., Faure, S., Challande, P., Osborne-Pellegrin, M., Martinez, M.C., Lacolley, P., Andriantsitohaina, R. Increased Microparticle Production and Impaired Microvascular Endothelial Function in Aldosterone-Salt-Treated Rats: Protective Effects of Polyphenols. PLoS One 2012; 7(-7-):U69-U82. >>> Aldosterone; SC; Rat; 2004; Animal info (Sprague Dawley, male, ); replacement therapy (uniphrectomy).

12366 Waeckel, L., Potier, L., Chollet, C., Taveau, C., Bruneval, P., Roussel, R., henc-Gelas, F., Bouby, N. Antihypertensive Role of Tissue Kallikrein in Hyperaldosteronism in the Mouse. Endocrinology 2012; 153(-8-):3886-3896. >>> Aldosterone; Saline, isotonic; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (TK -/-, wt).

12354 Lammers, C., Dartsch, T., Brandt, M.C., Rottlaender, D., Halbach, M., Peinkofer, G., Ockenpoehler, S., Weiergraeber, M., Schneider, T., Reuter, H., Mueller-Ehmsen, J., Hescheler, J., Hoppe, U.C., Zobel, C. Spironolactone Prevents Aldosterone Induced Increased Duration of Atrial Fibrillation in Rat. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2012; 29(-5-6-):833-840. >>> Aldosterone; PEG 400; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (Wistar, male, 233 g).

12292 van der Lubbe, N., Lim, C.H., Meima, M.E., van Veghel, R., Rosenbaek, L.L., Mutig, K., Danser, A.H.J., Fenton, R.A., Zietse, R., Hoorn, E.J. Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2012; 463(-6-):853-863. >>> Aldosterone; Rat; Controls received mp w/ vehicle; animal info (Sprague Dawley, 15 wks old, 370 g); replacement therapy (adrenalectomy).

12266 Ding, W., Yang, L., Zhang, M.M., Gu, Y. Chronic inhibition of nuclear factor kappa B attenuates aldosterone/salt-induced renal injury. LIFE SCIENCES 2012; 90(-15-16-):600-606. >>> Aldosterone; Ethanol; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 5 wks old, 180-208 g); 0.5% ethanol used; replacement therapy (nephrectomy).

12243 Sekizawa, N., Yoshimoto, T., Hayakawa, E., Suzuki, N., Sugiyama, T., Hirata, Y. Transcriptome analysis of aldosterone-regulated genes in human vascular endothelial cell lines stably expressing mineralocorticoid receptor. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2011; 341(-1-2-):78-88. >>> Aldosterone; SC; Rat; 2004; Animal info (Sprague Dawley, male, 8 wks old); replacement therapy (uniphrectomy).

12165 Kasal, D.A., Barhoumi, T., Li, M.W., Yamamoto, N., Zdanovich, E., Rehman, A., Neves, M.F., Laurant, P., Paradis, P., Schiffrin, E.L. T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury. Hypertension 2012; 59(-2-):324-U414. >>> Aldosterone; Mice; Animal info (male, C57BL6, 13-15 wks old, male).

12157 Liu, Y., Hirooka, K., Nishiyama, A., Lei, B., Nakamura, T., Itano, T., Fujita, T., Zhang, J.S., Shiraga, F. Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. Experimental Eye Research 2012; 96(-1-):116-123. >>> Aldosterone; DMSO; SC; Rat; 1007D; Animal info (Sprague Dawley, male, 200-250 g); 5% DMSO used; ischemia.

12141 Terada, Y., Ueda, S., Hamada, K., Shimamura, Y., Ogata, K., Inoue, K., Taniguchi, Y., Kagawa, T., Horino, T., Takao, T. Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1. Clinical and Experimental Nephrology 2012; 16(-1-):81-88. >>> Aldosterone; Ethanol; SC; Rat; 2002; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 150-200 g, uniphrectomized); replacement therapy (nephrectomy); 0.5% ethanol used.

12031 Ladage, D., Schuetzeberg, N., Dartsch, T., Krausgrill, B., Halbach, M., Zobel, C., Mueller-Ehmsen, J. Hyperaldosteronism is associated with a decrease in number and altered growth factor expression of endothelial progenitor cells in rats. International Journal of Cardiology 2011; 149(-2-):152-156. >>> Aldosterone; PEG 400; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (Wistar, male, adult, 300 g).

11964 Kawarazaki, H., Ando, K., Fujita, M., Matsui, H., Nagae, A., Muraoka, K., Kawarasaki, C., Fujita, T. Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats. American Journal of Physiology-Renal Physiology 2011; 300(-6-):F1402-F1409. >>> Aldosterone; SC; Rat; 2002; Animal info (Sprague Dawley, male, 3 wks old); functionality of mp verified via plasma aldosterone levels.

11918 Yan, Y.J., Ouyang, J., Wang, C., Wu, Z., Ma, X., Li, H.Z., Xu, H., Hu, Z., Li, J., Wang, B.J., Shi, T.P., Gong, D.J., Ni, D., Zhang, X. Aortic Cell Apoptosis in Rat Primary Aldosteronism Model. Journal of Huazhong University of Science and Technology-Medical Sciences 2010; 30(-3-):385-390. >>> Aldosterone; Propylene glycol; ethanol; water,; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 7 wks old, 230-250 g); pumps replaced after 4 weeks; long-term study; functionality of mp verified by plasma aldosterone levels.

11831 Pech, V., Pham, T.D., Hong, S., Weinstein, A.M., Spencer, K.B., Duke, B.J., Walp, E., Kim, Y.H., Sutliff, R.L., Bao, H.F., Eaton, D.C., Wall, S.M. Pendrin Modulates ENaC Function by Changing Luminal HCO(3)(-). Journal of the American Society of Nephrology 2010; 21(-11-):1928-1941. >>> Aldosterone; acetazolamide; Mice; Animal info (Pendrin-null, age, sex matched).

11647 van der Lubbe, N., Lim, C.H., Fenton, R.A., Meima, M.E., Danser, A.H.J., Zietse, R., Hoorn, E.J. Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone. Kidney International 2011; 79(-1-):66-76. >>> Dexamethasone; aldosterone; angiotensin II; Rat; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 15 wks old, 300 g); replacement therapy (adrenalectomy); blood pressure measured via tail-cuff (Kent Scientific).

11628 Thum, T., Schmitter, K., Fleissner, F., Wiebking, V., Dietrich, B., Widder, J.D., Jazbutyte, V., Hahner, S., Ertl, G., Bauersachs, J. Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans. European Heart Journal 2011; 32(-10-):1275-1286. >>> Aldosterone; Mice; 1002; Controls received mp w/ vehicle; animal info (male, 8 wks old).

11612 Shibata, S., Mu, S.Y., Kawarazaki, H., Muraoka, K., Ishizawa, K., Yoshida, S., Kawarazaki, W., Takeuchi, M., Ayuzawa, N., Miyoshi, J., Takai, Y., Ishikawa, A., Shimosawa, T., Ando, K., Nagase, M., Fujita, T. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. Journal of Clinical Investigation 2011; 121(-8-):3233-3243. >>> Aldosterone; SC; Rat; Controls were sham operated; animal info (Sprpague Dawley, 250-270 g).

11388 He, B.J., Joiner, M.L.A., Singh, M.V., Luczak, E.D., Swaminathan, P.D., Koval, O.M., Kutschke, W., Allamargot, C., Yang, J.Y., Guan, X.Q., Zimmerman, K., Grumbach, I.M., Weiss, R.M., Spitz, D.R., Sigmund, C.D., Blankesteijn, W.M., Heymans, S., Mohler, P.J., Anderson, M.E. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine 2011; 17(-12-):1610-U125. >>> Aldosterone; Ethanol; saline; Mice; Controls received mp w/ vehicle; animal info (Mmp9-/-, Ncf1-/-, 8-20 wks old); 5% ethanol used.

11272 Brem, A.S., Morris, D.J., Ge, Y., Dworkin, L., Tolbert, E., Gong, R.J. Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11 beta-HSD activity. American Journal of Physiology-Renal Physiology 2010; 298(-5-):F1178-F1187. >>> Aldosterone; RU-318; dehydrocorticosterone, 11-; corticosterone; DMSO; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL/6, 20-25 g).

11115 Griol-Charhbili, V., Fassot, C., Messaoudi, S., Perret, C., Agrapart, V., Jaisser, F. Epidermal Growth Factor Receptor Mediates the Vascular Dysfunction But Not the Remodeling Induced by Aldosterone/Salt. Hypertension 2011; 57(-2-):238-U205. >>> Aldosterone; Ethanol; SC; Mice; Controls received mp w/ vehicle; animal info (wa-2, wt, male); replacement therapy (nephrectomy); 10% ethanol used.

11010 Fukuda, S., Horimai, C., Harada, K., Wakamatsu, T., Fukasawa, H., Muto, S., Itai, A., Hayashi, M. Aldosterone-induced kidney injury is mediated by NFkappaB activation. Clinical and Experimental Nephrology 2011; 15(-1-):41-49. >>> Aldosterone, d-; Ethanol; water, dd-; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 6-7 wks old); replacement therapy (nephrectomized); 3% ethanol used.

10569 Huang, B.S., Ahmadi, S., Ahmad, M., White, R.A., Leenen, F.H.H. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain"pathway. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-2-):U207-U215. >>> Angiotensin II; FAD-286; aldosterone, d-; Saline; CSF, artificial; ethanol; SC; CSF/CNS; Rat; 2001D; 2001; 2002; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250 g); peptides; dose-response; enzyme inhibitor (aldosterone synthase); multiple pumps per animal (2); telemetry probe (model TA11PA-C40, DSI) used to measure BP and HR; 1% ethanol used with aldosterone.

10502 Wang, K., Long, B., Zhou, J., Li, P.F. miR-9 and NFATc3 Regulate Myocardin in Cardiac Hypertrophy. Journal of Biological Chemistry 2010; 285(-16-):11903-11912. >>> Isoproterenol; aldosterone; miR-9 mimic; Saline; ethanol; Mice; 2001; Controls received mimic negative control; animal info (male, C57BL/6, 8 wks old); cardiovascular; ds RNA oligonucleotide.

10351 Sam, F., Duhaney, T.A.S., Sato, K., Wilson, R.M., Ohashi, K., Sono-Romanelli, S., Higuchi, A., De Silva, D.S., Qin, F.Z., Walsh, K., Ouchi, N. Adiponectin Deficiency, Diastolic Dysfunction, and Diastolic Heart Failure. Endocrinology 2010; 151(-1-):322-331. >>> Aldosterone, d-; Mice; Controls received mp w/ saline; animal info (wt, C57BL6, apn KO, uniphrectomized).

10214 Matsubara, B.B., Franco, M., Janicki, J.S., Matsubara, L.S. Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. Brazilian Journal of Medical and Biological Research 2010; 43(-5-):506-514. >>> Aldosterone; SC; Rat; 2002; Control animals received no treatment; cardiovascular; animal info (male, Wistar, 300 g, 12 weeks old); replacement therapy (nephrectomy); pumps replaced; long-term study.

10210 Hunter, R.G., Bloss, E.B., McCarthy, K.J., McEwen, B.S. Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. Brain Research 2010; 1325(-;-):141-146. >>> Aldosterone; RU 28,362; SC; Rat; Controls received mp w/vehicle; animal info (male, Sprague-Dawley, 70 days old); replacement therapy (adrenalectomy).

10127 Kamalov, G., Ahokas, R.A., Zhao, W.Y., Shahbaz, A.U., Bhattacharya, S.K., Sun, Y., Gerling, I.C., Weber, K.T. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-2-):H385-H394. >>> Aldosterone; SC; Rat; Replacement therapy (uniphrectomy), animal info (8 wks old, Sprague Dawley, uniphrectomy).

 

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"Utilizing continuous minipump administration enhances the knockdown to 63% of control." (p. 619) This compared with 40% by twice daily administration. "The results of the present study confirm the utility of osmotic minipump administration of antisense oligonucleotides." (p. 621) Falk et al., Pharmacol Biochem Behav 2002;72:617-622.