References on the Administration of Aldosterone Using ALZET^® Osmotic Pumps

Q0759 Fukuda,S., Horimai,C., Harada,K., Wakamatsu,T., Fukasawa,H., Muto,S., Itai,A., Hayashi,M. Aldosterone-induced kidney injury is mediated by NFkappaB activation. Clinical and Experimental Nephrology 2011; 15(-1-):41-49. >>> Aldosterone, d-; Ethanol; water, dd-; SC; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; animal info (male, Wistar, 6-7 wks old); replacement therapy (nephrectomized); 3% ethanol used.

Q0864 Griol-Charhbili,V., Fassot,C., Messaoudi,S., Perret,C., Agrapart,V., Jaisser,F. Epidermal Growth Factor Receptor Mediates the Vascular Dysfunction But Not the Remodeling Induced by Aldosterone/Salt. Hypertension 2011; 57(-2-):238-U205. >>> Aldosterone; Ethanol; SC; Mice; 4 weeks; Controls received mp w/ vehicle; animal info (wa-2, wt, male); replacement therapy (nephrectomy); 10% ethanol used.

Q0320 Huang,B.S., Ahmadi,S., Ahmad,M., White,R.A., Leenen,F.H.H. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-2-):U207-U215. >>> Angiotensin II; FAD-286; aldosterone, d-; Saline; CSF, artificial; ethanol; SC; CSF/CNS; Rat; 2001D; 2001; 2002; 2004; 2 weeks; 1, 4 days; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250 g); peptides; dose-response; enzyme inhibitor (aldosterone synthase); multiple pumps per animal (2); telemetry probe (model TA11PA-C40, DSI) used to measure BP and HR; 1% ethanol used with aldosterone.

Q0018 Hunter,R.G., Bloss,E.B., McCarthy,K.J., McEwen,B.S. Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. Brain Research 2010; 1325(-;-):141-146. >>> Aldosterone; RU 28,362; SC; Rat; 7 days; Controls received mp w/vehicle; animal info (male, Sprague-Dawley, 70 days old); replacement therapy (adrenalectomy).

P9884 Kamalov,G., Ahokas,R.A., Zhao,W.Y., Shahbaz,A.U., Bhattacharya,S.K., Sun,Y., Gerling,I.C., Weber,K.T. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-2-):H385-H394. >>> Aldosterone; SC; Rat; ; Replacement therapy (uniphrectomy), animal info (8 wks old, Sprague Dawley, uniphrectomy).

Q0022 Matsubara,B.B., Franco,M., Janicki,J.S., Matsubara,L.S. Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. Brazilian Journal of Medical and Biological Research 2010; 43(-5-):506-514. >>> Aldosterone; SC; Rat; 2002; 6 weeks; Control animals received no treatment; cardiovascular; animal info (male, Wistar, 300 g, 12 weeks old); replacement therapy (nephrectomy); pumps replaced; long-term study.

Q0103 Sam,F., Duhaney,T.A.S., Sato,K., Wilson,R.M., Ohashi,K., Sono-Romanelli,S., Higuchi,A., De Silva,D.S., Qin,F.Z., Walsh,K., Ouchi,N. Adiponectin Deficiency, Diastolic Dysfunction, and Diastolic Heart Failure. Endocrinology 2010; 151(-1-):322-331. >>> Aldosterone, d-; Mice; 4 weeks; Controls received mp w/ saline; animal info (wt, C57BL6, apn KO, uniphrectomized).

Q0253 Wang,K., Long,B., Zhou,J., Li,P.F. miR-9 and NFATc3 Regulate Myocardin in Cardiac Hypertrophy. Journal of Biological Chemistry 2010; 285(-16-):11903-11912. >>> Isoproterenol; aldosterone; miR-9 mimic; Saline; ethanol; Mice; 2001; 1 week; Controls received mimic negative control; animal info (male, C57BL/6, 8 wks old); cardiovascular; ds RNA oligonucleotide.

P9368 Berka,J.L.W., Tan,G., Jaworski,K., Miller,A.G. Identification of a Retinal Aldosterone System and the Protective Effects of Mineralocorticoid Receptor Antagonism on Retinal Vascular Pathology. Circulation Research 2009; 104(-1-):124-U309. >>> Aldosterone; DMSO; saline; SC; Rat (neonate); 1007D; 7 days; Animal info (Sprague Dawley, OIR); 2% DMSO used.

P9403 De Silva,D.S., Wilson,R.M., Hutchinson,C., Ip,P.C., Garcia,A.G., Lancel,S., Ito,M., Pimentel,D.R., Sam,F. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-6-):H1983-H1993. >>> Aldosterone, D-; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (nephrectomy); cardiovascular; animal info (male, FVB).

Q0552 Fan,Y.Y., Kohno,M., Nakano,D., Hitomi,H., Nagai,Y., Fujisawa,Y., Lu,X.M., Fu,H., Du,J., Ohmori,K., Hosomi,N., Kimura,S., Kiyomoto,H., Nishiyama,A. Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. Journal of Hypertension 2009; 27(-9-):1855-1862. >>> Aldosterone; Ethanol; SC; Rat; 2004; 6 weeks; Controls received mp w/ vehicle; animal info (Sprague-Dawley, 162-184 g); pumps replaced every 3 weeks; long-term study; replacement therapy (nephrectomy); 2% ethanol used.

P9933 Frindt,G., Palmer,L.G. Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. American Journal of Physiology-Renal Physiology 2009; 297(-5-):F1249-F1255. >>> Aldosterone; PEG 300; SC; Rat; 2002; 6-7 days; Animal info (Sprague Dawley, 250-300 g).

Q0548 Gomez,A.M., Rueda,A., Sainte-Marie,Y., Pereira,L., Zissimopoulos,S., Zhu,X., Schaub,R., Perrier,E., Perrier,R., Latouche,C., Richard,S., Picot,M.C., Jaisser,F., Lai,F.A., Valdivia,H.H., Benitah,J.P. Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins. Circulation 2009; 119(-16-):2179-2U89. >>> Aldosterone, d-; Saline; SC; Mice; 3 weeks; Gender-matched WT used as controls; animal info (hMR Tg); incorrectly stated Model 2ML4 used.

P9913 Guagliardo,N.A., West,K.N., McCluskey,L.P., Hill,D.L. Attenuation of peripheral salt taste responses and local immune function contralateral to gustatory nerve injury: effects of aldosterone. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 297(-4-):R1103-R1110. >>> Aldosterone; Saline; PEG300; SC; Rat; ; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 40-60 days old).

Q0091 Hunter,R.G., Bellani,R., Bloss,E., Costa,A., McCarthy,K., McEwen,B.S. Regulation of Kainate Receptor Subunit mRNA by Stress and Corticosteroids in the Rat Hippocampus. PLoS One 2009; 4(-1-):U82-U88. >>> Aldosterone; RU 28,362; Polyethylene gylcol; SC; Rat; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult).

P9350 Luther,J.M., Wang,Z., Ma,J., Makhanova,N., Kim,H.S., Brown,N.J. Endogenous Aldosterone Contributes to Acute Angiotensin II-Stimulated Plasminogen Activator Inhibitor-1 and Preproendothelin-1 Expression in Heart But Not Aorta. Endocrinology 2009; 150(-5-):2229-2236. >>> Aldosterone; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; animal info (AS -/-, 8-14 wks old); dose (0.021 mg/ml).

Q0211 Nakamura,T., Kataoka,K., Fukuda,M., Nako,H., Tokutomi,Y., Dong,Y.F., Ichijo,H., Ogawa,H., Kim-Mitsuyama,S. Critical Role of Apoptosis Signal-Regulating Kinase 1 in Aldosterone/Salt-Induced Cardiac Inflammation and Fibrosis. Hypertension 2009; 54(-3-):544-U197. >>> Aldosterone; potassium chloride; Mice; 1002; 4 weeks; Controls received mp w/ saline; animal info (ASK1 -/-, wt).

Q0565 rias-Loza,P.A., Muehlfelder,M., Elmore,S.A., Maronpot,R., Hu,K., Blode,H., Hegele-Hartung,C., Fritzemeier,K.H., Ertl,G., Pelzer,T. Differential Effects of 17-beta-Estradiol and of Synthetic Progestins on Aldosterone-Salt-Induced Kidney Disease. Toxicologic Pathology 2009; 37(-7-):969-982. >>> Aldosterone; NaCl; Rat; ; Animal info (female, Wistar); replacement therapy (uniphrectomy).

P9440 Saito,T., Saito,T., Kasono,K., Otani,T., Tamemoto,H., Kawakami,M., Sasaki,S., Ishikawa,S. Vasopressin-dependent upregulation of aquaporin-2 gene expression in aged rats with glucocorticoid deficiency. ACTA PHYSIOLOGICA 2009; 196(-2-):239-247. >>> Aldosterone; dexamethasone; SC; Rat; 2ML4; 17 days; Controls received mp w/ both agents; replacement therapy (adrenalectomy); animal info (male, Sprague Dawley, 6 wks old, 200-250 g.; 52 wks old, 650-700 g.); nephrology.

Q0826 Tasatargil,A., Tekcan,M., Celik-Ozenci,C., Gungor,N.E., Dalkiran,B. Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 2009; 10(-3-):127-137. >>> Aldosterone; Saline; SC; Rat; 2004; 21 days; Controls received mp w/ vehicle; animal info (male, Wistar, 6-8 wks old, 250-300 g).

Q0210 Wilson,R.M., De Silva,D.S., Sato,K., Izumiya,Y., Sam,F. Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure. Hypertension 2009; 54(-3-):583-U265. >>> Aldosterone, d-; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (uniphrectomized); animal info (10 wks old, FVB, UNX, 25-27 g.).

P9467 Xue,B.J., Badaue-Passos,D.Jr, Guo,F., Gomez-Sanchez,C.E., Hay,M., Johnson,A.K. Sex differences and central protective effect of 17 beta-estradiol in the development of aldosterone/NaCl-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-5-):H1577-H1585. >>> Aldosterone; estradiol, 17b-; ICI 182,780; SC; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy, castration); cardiovascular; multiple pumps per animal (2); animal info (male, Sprague Dawley, 10-12 wks old); cannula placement verified histologically; estrogen receptor antagonist; endocrinology.

Q0667 Zhang,M.M., Chen,J., Liu,S.J., You,L., Lin,S.Y., Gu,Y. The Role of Na(+)-H(+) Exchanger Isoform 1 in Aldosterone-Induced Glomerulosclerosis in Vivo. RENAL FAILURE 2009; 31(-8-):726-735. >>> Aldosterone; Saline; SC; Rat; 2004; 12 weeks; Controls received mp w/ vehicle; animal info (5 wks old, male, Sprague-Dawley, 180-210 g, nephrectomized); pumps replaced every 4 weeks; replacement therapy (nephrectomy).

P9021 Chun,T.Y., Chander,P.N., Kim,J.W., Pratt,J.H., Stier,CT Jr  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 295(-2-):E305-E312. >>> Angiotensin II; aldosterone; Ethanol; SC; Rat; 2 weeks; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); animal info (male, SHRSP/A3N, 60 days old, adrenalectomy); peptides.

P8777 Fejes-Toth,G., Frindt,G., Naray-Fejes-Toth,A., Palmer,L.G. Epithelial Na+ channel activation and processing in mice lacking SGK1. American Journal of Physiology-Renal Physiology 2008; 294(-6-):F1298-F1305. >>> Aldosterone; PEG 300; SC; Mice; 2001; 6-7 days; Animal info (129/SvJ, wt, SGK1 -/-).

P8913 Mathew,J.T., Patni,H., Chaudhary,A.N., Liang,W., Gupta,A., Chander,P.N., Ding,G., Singhal,P.C. Aldosterone induces mesangial cell apoptosis both in vivo and in vitro. American Journal of Physiology-Renal Physiology 2008; 295(-1-):F73-F81. >>> Aldosterone; eplerenone; Saline; SC; Rat; 2002; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 180-220 g.); eplerenone is an aldosterone antagonist.

Q0749 Minnaard-Huiban,M., Hermans,J.J.R., van Essen,H., Bitsch,N., Smits,J.F.M. Comparison of the effects of intrapericardial and intravenous aldosterone infusions on left ventricular fibrosis in rats. EUROPEAN JOURNAL OF HEART FAILURE 2008; 10(-12-):1166-1171. >>> Aldosterone; Polyethylene glycol; water; IV; intrapericardial; Rat; 2004; 8 weeks; Controls received mp w/ vehicle; long-term study; animal info (male, Wistar, 280-320 g); pumps replaced after 4 weeks.

P9541 Park,Y.M., Lim,B.H., Touyz,R.M., Park,J.B. Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat. Journal of Korean Medical Science 2008; 23(-6-):1039-1045. >>> Aldosterone; Saline; SC; Rat; 2002; 6 weeks; Controls received mp w/vehicle, or sham operation; long-term study; pumps replaced every 2 weeks; animal info (male, Sprague Dawley, 8 wks old, 250g).

P8754 Picard,N., Eladari,D., El Moghrabi,S., Planes,C., Bourgeois,S., Houillier,P., Wang,Q., Burnier,M., Deschenes,G., Knepper,M.A., Meneton,P., Chambrey,R. Defective ENaC processing and function in tissue kallikrein-deficient mice. Journal of Biological Chemistry 2008; 283(-8-):4602-4611. >>> Aldosterone; Saline; Me2S0; Mice; 2004; 28 days; Controls received mp w/ vehicle; animal info (TK -/-, wt); nephrology.

P8802 Selektor,Y., Ahokas,R.A., Bhattacharya,S.K., Sun,Y., Gerling,I.C., Weber,K.T. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. American Journal of the Medical Sciences 2008; 335(-2-):105-110. >>> Aldosterone; Rat; 4 weeks; Controls received no treatment; replacement therapy (uninephrectomy); cardiovascular; animal info (male, Sprague Dawley).

P9146 Zhang,Z.H., Yu,Y., Kang,Y.M., Wei,S.G., Felder,R.B. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H1067-H1074. >>> Aldosterone; RU-28318; Tempol; losartan; CSF, artificial; CSF/CNS; Rat; 2002; 1 week; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, Sprague Dawley, 250-300 g.); silastic tubing used; dental cement used.

P8600 de Seigneux,S., Nielsen,J., Olesen,E.T.B., Dimke,H., Kwon,T.H., Frokiaer,J., Nielsen,S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; 6,7,8 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

P8551 Frindt,G., Ergonul,Z., Palmer,L.G. Na channel expression and activity in the medullary collecting duct of rat kidney. American Journal of Physiology-Renal Physiology 2007; 292(-4-):F1190-F1196. >>> Aldosterone; PEG 300; SC; Rat; 2002; 6-7 days; Animal info (male, female, Sprague-Dawley, 150-170 grams).

P8577 Grossmann,C., Krug,A.W., Freudinger,R., Mildenberger,S., Voelker,K., Gekle,M. Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am.J.Physiol Endocrinol.Metab 2007/6; 292(-6-):E1790-E1800. >>> Aldosterone; dexamethasone; DMSO; Rat; 2ML1; 6 days; Controls received mp w/ vehicle; functionality of mp verified by plasma concentrations; replacement therapy (adrenalectomy); animal info (male, Munich-Wistar, 200-250 grams); endocrinology.

P8151 Hirono,Y., Yoshimoto,T., Suzuki,N., Sugiyama,T., Sakurada,M., Takai,S., Kobayashi,N., Shichiri,M., Hirata,Y. Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: The possible role of local renin-angiotensin system. Endocrinology 2007; 148(-4-):1688-1696. >>> Aldosterone, D-; Water, distilled; propylene glycol; ethanol; SC; Rat; 2004; 3 weeks; Blood pressure taken; replacement therapy (uninephrectomy); cardiovascular; animal info (7 weeks old, male, Sprague-Dawley); 9% ethanol used.

P8517 Hunter,R.G., Bellani,R., Bloss,E., Costa,A., Romeo,R.D., McEwen,B.S. Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala. Brain Research 2007; 1152(--):234-240. >>> Aldosterone; RU28362; Propylene glycol; SC; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); animal info (male, Sprague-Dawley, 21 or 70 days old).

P8537 Kim,Y.H., Pech,V., Spencer,K.B., Beierwaltes,W.H., Everett,L.A., Green,E.D., Shin,W., Verlander,J.W., Sutliff,R.L., Wall,S.M. Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice. American Journal of Physiology-Renal Physiology 2007; 293(-4-):F1314-F1324. >>> Aldosterone; Saline; DMSO; SC; Mice; 7 days; Controls received mp w/ vehicle; functionality of mp verified by serum aldosterone levels; 2.4% DMSO used.

P8722 LeBrasseur,N.K., Duhaney,T.A.S., De Silva,D.S., Cui,L., Ip,P.C., Joseph,L., Sam,F. Effects of fenofibrate on cardiac remodeling in aldosterone-induced hypertension. Hypertension 2007; 50(-3-):489-496. >>> Aldosterone, d-; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (uninephrectomy); no stress (see pg. 490); cardiovascular; animal info (FVB, 12 wks old, 27-30g).

P8380 Leopold,J.A., Dam,A., Maron,B.A., Scribner,A.W., Liao,R., Handy,D.E., Stanton,R.C., Pitt,B., Loscalzo,J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nature Medicine 2007; 13(-2-):189-197. >>> Aldosterone; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels and systolic BP; cardiovascular; animal info (male, C3H wt; G6PD-deficient, 12-16 wks old).

P8248 Nielsen,J., Kwon,T.H., Frokiaer,J., Knepper,M.A., Nielsen,S. Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade. American Journal of Physiology-Renal Physiology 2007; 292(-1-):F382-F394. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7, 10 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; dose-response (pg F383); no stress (see pg F384); post op. care (bupivacaine); animal info (male, Sprague-Dawley, 190-210g); 25% DMSO.

P8398 Peng,H.M., Carretero,O.A., Liao,T.D., Peterson,E.L., Rhaleb,N.E. Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension 2007; 49(-3-):695-703. >>> Aldosterone; peptide, Ac-SDKP; SC; Rat; 2ML4; 6 weeks; Controls received sham treatment; replacement therapy (left kidney removed); pumps replaced; half-life (pg. 700) 4.5 minutes in the circulation (Ac-SDKP); cardiovascular; peptides; animal info (male, Sprague-Dawley, 10 wks old, 325-350g.).

P8440 Shibata,S., Nagase,M., Yoshida,S., Kawachi,H., Fujita,T. Podocyte as the target for aldosterone - Roles of oxidative stress and Sgk1. Hypertension 2007; 49(-2-):355-364. >>> Aldosterone; SC; Rat; 2004; 2,4,6 weeks; Controls received no treatment; replacement therapy (uninephrectomy); cardiovascular; animal info (Sprague-Dawley, 300-350 g); nephrology.

P7841 Buss,S.J., Backs,J., Kreusser,M.M., Hardt,S.E., Maser-Gluth,C., Katus,H.A., Haass,M. Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats. Endocrinology 2006; 147(-5-):2526-2534. >>> Aldosterone, D-; Rat; 2004; 28 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; cardiovascular; animal info (male, Wistar, 200g.).

P7777 Fan,Y.Y., Baba,R., Nagai,Y., Miyatake,A., Hosomi,N., Kimura,S., Sun,G.P., Kohno,M., Fujita,M., Abe,Y., Nishiyama,A. Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; Renoprotective effects of an ultrahigh dose of olmesartan. HYPERTENSION RESEARCH 2006; 29(-3-):169-178. >>> Aldosterone; Ethanol; SC; Rat; 2002; 3, 6 weeks; Controls received mp w/ vehicle; replacement therapy (uninephrectomy); long-term study; pumps replaced every 2 weeks; cardiovascular; animal info (male, Sprague-Dawley, 162-184g.); 2% ETOH.

P8122 Fukushima,K., Haneda,S., Takahashi,K.I., Gawa,H., Watanabe,K., Funayama,Y., Shibata,C., Sasaki,I. Molecular analysis of colonic transformation in the ileum after total colectomy in rats. Surgery 2006; 140(-1-):93-99. >>> Aldosterone, D-; PEG 400; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 8 wk old, 250-300g.); gene expression.

P7667 Geerling,J.C., Engeland,W.C., Kawata,M., Loewy,A.D. Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite. Journal of Neuroscience 2006; 26(-2-):411-417. >>> Aldosterone; Saline; ethanol; IP; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; replacement therapy (bilateral adrenalectomy); animal info (male, Sprague-Dawley, 275-325 g); 1 % ETOH.

P8449 Goodwin,K.D., Ahokas,R.A., Bhattacharya,S.K., Sun,Y., Gerling,I.C., Weber,K.T. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. American Journal of the Medical Sciences 2006; 332(-2-):73-78. >>> Aldosterone; calcitriol; SC; Rat; 2004; 2ML4; 4 weeks; Controls received no treatment; replacement therapy (uninephrectomy); cardiovascular; animal info (male, Sprague-Dawley, 8 wks old).

P8970 Johar,S., Cave,A.C., Narayanapanicker,A., Grieve,D.J., Shah,A.M. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB Journal 2006; 20(-9-):U291-U299. >>> Angiotensin II; aldosterone; SC; Mice; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; replacement therapy (nephrectomy); cardiovascular; peptides; animal info (male, C57BL6/J, wt, Nox2 -/-).

P8358 Klein,J.D., Kozlowski,S., Antoun,T.A., Sands,J.M. Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney. Journal of Membrane Biology 2006; 212(-2-):139-144. >>> Aldosterone; Rat; 14 days; Replacement therapy (adrenalectomy, STZ-induced diabetes mellitus); animal info (male, Sprague-Dawley, 100-150 grams); endocrinology.

P7809 Ma,J., Weisberg,A., Griffin,J.P., Vaughan,D.E., Fogo,A.B., Brown,N.J. Plasminogen activator inhibitor-1 deficiency protects against aldosterone- induced glomerular injury. Kidney International 2006; 69(-6-):1064-1072. >>> Aldosterone, D-; DMSO; SC; Mice; 2004; 12 weeks; Controls received mp w/ vehicle; replacement therapy (uninephrectomy); long-term study; pumps replaced every 4 weeks; cardiovascular; animal info (male, C57BL/6J wt or PAI-1(-/-), 8-10 wk old, 27g.); 3.6% DMSO; nephrology.

P8100 Nehme,J., Mercier,N., Labat,C., Benetos,A., Safar,M.E., Delcayre,C., Lacolley,P. Differences between cardiac and arterial fibrosis and stiffness in aldosterone-salt rats: Effect of eplerenone. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 2006; 7(-1-):31-39. >>> Aldosterone, D-; SC; Rat; 2004; 28 days; Controls received mp w/ physiological serum; replacement therapy (uninephrectomy); cardiovascular; animal info (male, Sprague-Dawley, 8 wk old, 300g.).

P7732 Nielsen,J., Kwon,T.H., Frokiaer,J., Knepper,M.A., Nielsen,S. Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD. American Journal of Physiology-Renal Physiology 2006; 290(-5-):F1222-F1233. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7 days; Controls received no treatment; animal info (male, wistar, 190-210g.); 25% DMSO.

P7466 Nielsen,J., Kwon,T.H., Praetorius,J., Frokiaer,J., Knepper,M.A., Nielsen,S. Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus. American Journal of Physiology-Renal Physiology 2006; 290(-2-):F438-F449. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7 days; Controls received no treatment; animal info (male, Wistar, 180 g); 25% DMSO.

P9003 O'Reilly,M., Marshall,E., MacGillivray,T., Mittal,M., Xue,W., Kenyon,C.J., Brown,R.W. Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. Journal of the American Society of Nephrology 2006; 17(-9-):2402-2413. >>> Aldosterone; SC; Mice; 6 days; Controls received mp w/ saline; replacement therapy (adrenalectomy); animal info (male, C57BL/6, 25-30 g.); nephrology.

P8376 Rahman,M., Nishiyama,A., Guo,P., Nagai,Y., Zhang,G.X., Fujisawa,Y., Fan,Y.Y., Kimura,S., Hosomi,N., Omori,K., Abe,Y., Kohno,M. Effects of adrenomedullin on cardiac oxidative stress and collagen accumulation in aldosterone-dependent malignant hypertensive rats. Journal of Pharmacology and Experimental Therapeutics 2006; 318(-3-):1323-1329. >>> Aldosterone; adrenomedullin; Ethanol; SC; Rat; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, SHR, Wistar-Kyoto, 10 wks old, 240-295g.); 0.5% EtOH.

P8355 rias-Loza,P.A., Hu,K., Schaefer,A., Bauersachs,J., Quaschning,T., Galle,J., Jazbutyte,V., Neyses,L., Ertl,G., Fritzemeier,K.H., Hegele-Hartung,C., Pelzer,T. Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats. Hypertension 2006; 48(-5-):994-1001. >>> Aldosterone; SC; Rat; ; Controls received sham treatment; replacement therapy (ovariectomy, uninephrectomy); cardiovascular; animal info (female, Wistar, 250-300 grams).

P9002 Sun,G.P., Kohno,M., Guo,P., Nagai,Y., Miyata,K., Fan,Y.Y., Kimura,S., Kiyomoto,H., Ohmori,K., Li,D.T., Abe,Y., Nishiyama,A. Involvements of rho-kinase and TGF-beta pathways in aldosterone-induced renal injury. Journal of the American Society of Nephrology 2006; 17(-8-):2193-2201. >>> Aldosterone; Ethanol; SC; Rat; 2002; 5 weeks; Controls received mp w/ vehicle; replacement therapy (uninephrectomy); pumps replaced every 2 weeks; cardiovascular; animal info (male, Sprague Dawley, 5 wks old, 182-206 g.); 2% ethanol used; nephrology.

P7927 Tiwari,S., Packer,R.K., Hu,X.Q., Sugimura,Y., Verbalis,J.G., Ecelbarger,C.A. Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. American Journal of Physiology-Renal Physiology 2006; 291(-1-):F49-F57. >>> Vasopressin, 1-desamino-8-D-arginine; aldosterone; SC; Rat; 2002; ; Blood pressure taken; replacement therapy (adrenalectomy); multiple pumps per animal (2); animal info (male, Sprague-Dawley, 275 grams, ADX); dDAVP; one pump for each drug.

P7513 Vidal,A., Sun,Y., Bhattacharya,S.K., Ahokas,R.A., Gerling,I.C., Weber,K.T. Calcium paradox of aldosteronism and the role of the parathyroid glands. American Journal of Physiology-Heart and Circulatory Physiology 2006; 290(-1-):H286-H294. >>> Aldosterone; Rat; 1, 2, 4, 6 weeks; Controls received no treatment; replacement therapy (uninephrectomy, parathyroidectomy); cardiovascular; animal info (male, Sprague-Dawley, 9 wk old).

P7743 Wang,W.D., Li,C.L., Summer,S.N., Falk,S., Cadnapaphornchai,M.A., Chen,Y.C., Schrier,R.W. Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiency. American Journal of Physiology-Renal Physiology 2006; 290(-5-):F1135-F1142. >>> Aldosterone; IP; Rat; 2ML4; 12 days; Replacement therapy (adrenalectomy); animal info (male, Wistar, 160-180g.).

P7225 Cassis,L.A., Helton,M.J., Howatt,D.A., King,V.L., Daugherty,A. Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. British Journal of Pharmacology 2005; 144(-3-):443-448. >>> Aldosterone; angiotensin II; Propylene glycol; saline; ethanol; water; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; replacement therapy (hyperlipidemic); no stress (see pg. 444); cardiovascular; 9% ethanol.

P8063 Chen,Y.C., Cadnapaphornchai,M.A., Summer,S.N., Falk,S., Li,C.L., Wang,W.D., Schrier,R.W. Molecular mechanisms of impaired urinary concentrating ability in glucocorticoid-deficient rats. Journal of the American Society of Nephrology 2005; 16(-10-):2864-2871. >>> Aldosterone; IP; Rat; 2ML4; 11 days; Controls received mp w/ agent plus SC injections of dexamethasone; replacement therapy (adrenalectomy); animal info (male, Sprague-Dawley, 175-200g.); nephrology.

P7224 Chhokar,V.S., Sun,Y., Bhattacharya,S.K., Ahokas,R.A., Myers,L.K., Xing,Z.Q., Smith,R.A., Gerling,I.C., Weber,K.T. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation 2005; 111(-7-):871-878. >>> Aldosterone; SC; Rat; 1,2,4,6 weeks; Controls received no treatment; replacement therapy (uninephrectomy); no stress (see pg. 873); cardiovascular.

P7177 Crowley,S.D., Gurley,S.B., Oliverio,M.I., Pazmino,A.K., Griffiths,R., Flannery,P.J., Spurney,R.F., Kim,H.S., Smithies,O., Le,T.H., Coffman,T.M. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. Journal of Clinical Investigation 2005; 115(-4-):1092-1099. >>> Aldosterone; dexamethasone; PEG 400; saline, normal; SC; Mice; 2004; ; Replacement therapy (adrenalectomy, nephrectomy).

P7445 Fukushima,K., Funayama,Y., Yonezawa,H., Takahashi,K., Haneda,S., Suzuki,T., Sasano,H., Naito,H., Shibata,C., Krozowski,Z.S., Sasaki,I. Aldosterone enhances 11beta-hydroxysteroid dehydrogenase type 2 expression in colonic epithelial cells in vivo. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2005; 40(-7-):850-857. >>> Aldosterone, D-; PEG 400; SC; Rat; 2ML4; 1,2,4 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone concentration; comparison of sodium-depleted diet vs.mp; animal info (male, Sprague-Dawley, 250-300 g).

P7072 Kademian,S.M.E., Bignante,A.E., Lardone,P., McEwen,B.S., Volosin,M. Biphasic effects of adrenal steroids on learned helplessness behavior induced by inescapable shock. Neuropsychopharmacology 2005; 30(-1-):58-66. >>> Aldosterone, D-; Propylene glycol; SC; Rat; 2001; 3 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy).

P7628 Perrier,R., Richard,S., Sainte-Marie,Y., Rossier,B.C., Jaisser,F., Hummler,E., Benitah,J.P. A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice. JOURNAL OF PHYSIOLOGY-LONDON 2005; 569(-1-):153-162. >>> RU-28318; aldosterone; Saline; SC; Mice (transgenic); 2004; 3 weeks; Controls received mp w/ serum.

P6737 Sato,S., Fukushima,K., Naito,H., Funayama,Y., Suzuki,T., Sasano,H., Krozowski,Z., Shibata,C., Sasaki,I. Induction of 11 beta-hydroxysteroid dehydrogenase type 2 and hyperaldosteronism are essential for enhanced sodium absorption after total colectomy in rats. Surgery 2005; 137(-1-):75-84. >>> Aldosterone; PEG 400; SC; Rat; 2ML4; 1,2,4 weeks; Aldo plasma levels taken; replacement therapy (colectomy); no stress (see pg. 76).

P6393 Bhargava,A., Wang,J., Pearce,D. Regulation of epithelial ion transport by aldosterone through changes in gene expression. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2004; 217(-1-2-):189-196. >>> Aldosterone; SC; Rat; 24 hours; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); half-life (p. 192), 20 minutes; pump model not listed.

P6544 Buffin-Meyer,B., Younes-Ibrahim,M., El Mernissi,G., Cheval,L., Marsy,S., Grima,M., Girolami,J.P., Doucet,A. Differential regulation of collecting duct Na+,K+-ATPase and K+ excretion by furosemide and piretanide: Role of bradykinin. Journal of the American Society of Nephrology 2004; 15(-4-):876-884. >>> Furosemide; dexmethasone; diretanide; aldosterone; Hoe 140; Saline; SC; IP; Rat; 6 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); solution was a pH 9.0; a third group was adrenalectomized and given dexamethasone and aldosterone by a SC ALZET pump; in a fifth set of experiments Hoe140 was infused SC.

P6505 Frindt,G., Palmer,L.G. Na channels in the rat connecting tubule. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F669-F674. >>> Aldosterone; PEG 300; SC; Rat; 2002; 1 week.

P7056 Fukushima,K., Naito,H., Funayama,Y., Yonezawa,H., Haneda,S., Shibata,C., Sasaki,I. In vivo induction of prostasin mRNA in colonic epithelial cells by dietary sodium depletion and aldosterone infusion in rats. Journal of Gastroenterology 2004; 39(-10-):940-947. >>> Aldosterone, D-; PEG 400; SC; Rat; 2ML4; 1,2,4 weeks; Controls received mp w/ vehicle, or sodium-depleted diet; no stress (see pg. 941).

P6605 Gertner,R.A., Klein,J.D., Bailey,J.L., Kim,D.U., Luo,X.H., Bagnasco,S.M., Sands,J.M. Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor. Journal of the American Society of Nephrology 2004; 15(-3-):558-565. >>> Aldosterone; spironolactone; dexamethasone; Saline; DMSO; SC; Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy);<10% DMSO used.

P6847 Gomez-Sanchez,E.P., Ahmad,N., Romero,D.G., Gomez-Sanchez,C.E. Origin of aldosterone in the rat heart. Endocrinology 2004; 145(-11-):4796-4802. >>> Aldosterone; Rat; 8 days; Replacement therapy (adrenalectomy); cardiovascular.

P7033 Iglarz,M., Touyz,R.M., Viel,E.C., Amiri,F., Schiffrin,E.L. Involvement of oxidative stress in the profibrotic action of aldosterone - Interaction with the renin-angiotensin system. American Journal of Hypertension 2004; 17(-7-):597-603. >>> Aldosterone, D-; SC; Rat; 2002; 6 weeks; Controls received no treatment; functionality of mp verified by systolic BP; pumps replaced every two weeks; no stress (pg. 599); cardiovascular.

P6529 Juknevicius,I., Segal,Y., Kren,S., Lee,R., Hostetter,T.H. Effect of aldosterone on renal transforming growth factor-beta. American Journal of Physiology-Renal Physiology 2004; 286(-6-):F1059-F1062. >>> Aldosterone; Saline; SC; Rat; 3 days; Controls received mp w/ vehicle; blood pressure and aldosterone plasma levels taken; pump model not listed.

P6649 Keidar,S., Kaplan,M., Pavlotzky,E., Coleman,R., Hayek,T., Hamoud,S., Aviram,M. Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development - A possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Circulation 2004; 109(-18-):2213-2220. >>> Aldosterone; Saline; ethanol; Mice; 1002; 1,2,4 weeks; Controls received mp w/ vehicle; dose-response (table 1); cardiovascular.

P7129 Liu,Y., Imai,H., Sadamatsu,M., Tsunashima,K., Kato,N. Cytokines participate in neuronal death induced by trimethyltin in the rat hippocampus via type II glucocorticoid receptors. NEUROSCIENCE RESEARCH 2004; 50(--):209-217. >>> Aldosterone; dexamethasone; SC; Rat; 11,21 days; Controls received sham operation; replacement therapy (adrenalectomy).

P6490 Michel,F., Ambroisine,M.L., Duriez,M., Delcayre,C., Levy,B.I., Silvestre,J.S. Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway. Circulation 2004; 109(-16-):1933-1937. >>> Aldosterone; SC; Mice; 2004; 21 days; Controls received no treatment; cardiovascular; ischemia (cardiac).

P6479 Nishiyama,A., Yao,L., Nagai,Y., Miyata,K., Yoshizumi,M., Kagami,S., Kondo,S., Kiyomoto,H., Shokoji,T., Kimura,S., Kohno,M., Abe,Y. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004; 43(-4-):841-848. >>> Aldosterone; Ethanol; SC; Rat; 2002; 6 weeks; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular.

P6692 Sam,F., Xie,Z.L., Ooi,H., Kerstetter,D.L., Colucci,W.S., Singh,M., Singh,K. Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion. American Journal of Hypertension 2004; 17(-2-):188-193. >>> Aldosterone; Saline; SC; Mice (knockout); 4 weeks; 7 days; Controls received mp w/ vehicle; blood pressure taken; pump model not listed.

P6122 Ahokas,R.A., Warrington,K.J., Gerling,I.C., Sun,Y., Wodi,L.A., Herring,P.A., Lu,L., Bhattacharya,S.K., Postlethwaite,A.E., Weber,K.T. Aldosteronism and peripheral blood mononuclear cell activation - A neuroendocrine-immune interface. Circulation Research 2003; 93(-10-):E124-E135. >>> Aldosterone; SC; Rat; 1-4 weeks; Pump model not stated.

P5934 Chander,P.N., Rocha,R., Ranaudo,J., Singh,G., Zuckerman,A., Stier,CT Jr  Journal of the American Society of Nephrology 2003; 14(-8-):1990-1997. >>> Angiotensin II; aldosterone; Ethanol; SC; Rat; 2 weeks; Replacement therapy (adrenalectomy); pump model not stated.

P5720 Jiang,G.R., Cobbs,S., Klein,J.D., O'Neill,W.C. Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle. Hypertension 2003; 41(-5-):1131-1135. >>> Aldosterone; DMSO; saline; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; serum aldosterone levels checked; replacement therapy (adrenalectomy); cardiovascular; 10% DMSO used.

P6034 Krug,A.W., Grossmann,C., Schuster,C., Freudinger,R., Mildenberger,S., Govindan,M.V., Gekle,M. Aldosterone stimulates epidermal growth factor receptor expression. Journal of Biological Chemistry 2003; 278(-44-):43060-43066. >>> Aldosterone; SC; Rat; 2ML1; 1 week; Controls received mp w/ vehicle; aldosterone plasma levels taken; replacement therapy (adrenalectomy).

P6120 Krug,A.W., Papavassiliou,F., Hopfer,U., Ullrich,K.J., Gekle,M. Aldosterone stimulates surface expression of NHE3 in renal proximal br ush borders. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2003; 446(-4-):492-496. >>> Aldosterone; dexamethasone; SC; Rat; 2ML1; 5 days; Functionality of mp verified by aldosterone plasma levels; replacement therapy (adrenalectomy).

P6032 Lim,W.C., Park,J.B., Lee,Y.J. Analysis of angiotensin II mediated COX-2 Downregulation in angiotensin II- or aldosterone-infused hypertensive rat. BIOLOGICAL&PHARMACEUTICAL BULLETIN 2003; 26(-8-):1086-1088. >>> Angiotensin II; aldosterone; Saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; peptides.

P6044 Ma,L.J., Yang,H.C., Gaspert,A., Carlesso,G., Barty,M.M., Davidson,J.M., Sheppard,D., Fogo,A.B. Transforming growth factor-b-dependent and -independent pathways of induction of tubulointerstitial fibrosis in b6-/- mice. American Journal of Pathology 2003; 163(-4-):1261-1273. >>> Angiotensin II; aldosterone; IP; Mice (knockout); 1002; 2 weeks; Comparison of aldo pellets vs. IP mp; peptides.

P5650 Neves,M.F., Virdis,A., Schiffrin,E.L. Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism. Journal of Hypertension 2003; 21(-1-):189-198. >>> Angiotensin II; Aldosterone, d-; Saline; SC; Rat; 2002; 2 weeks; Cardiovascular.

P6724 Park,Y.M., Park,M.Y., Suh,Y.L., Park,J.B. NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats. Biochemical and Biophysical Research Communications 2003; 313(-3-):812-817. >>> Aldosterone; Saline; SC; 2002; 6 weeks; Controls received mp w/ vehicle; blood pressure taken; pumps replaced every two weeks; cardiovascular.

P6111 Rubera,I., Loffing,J., Palmer,L.G., Frindt,G., Fowler-Jaeger,N., Sauter,D., Carroll,T., McMahon,A., Hummler,E., Rossier,B.C. Collecting duct-specific gene inactivation ofαENaC in the mouse kidney does not impair sodium and potassium balance. Journal of Clinical Investigation 2003; 112(-4-):554-565. >>> Aldosterone; PEG 300; SC; Mice; 1002; 6 days.

R0201 Sun,Y., Weber,K.T. RAS and connective tissue in the heart. INTERNATIONAL JOURNAL OF BIOCHEMISTRY&CELL BIOLOGY 2003; 35(-6-):919-931. >>> Angiotensin II; aldosterone; Rat; 3 weeks; Replacement therapy (uninephrectomy); cardiovascular.

P6083 Turban,S., Wang,X.Y., Knepper,M.A. Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO. American Journal of Physiology-Renal Physiology 2003; 285(-5-):F843-F851. >>> Angiotensin II; aldosterone; L-NAME; Acetic acid; DMSO; saline; water; SC; Rat; 2001; 2ML1; 7 days; Controls received mp w/ vehicle; peptides; angiotensin II dissolved in acetic acid; albo dissolved in 30% DMSO/saline; L-NAME dissolved in water.

P6117 Wang,H., Huang,B.S., Leenen,F.H.H. Brain sodium channels and ouabainlike compounds mediate central aldosterone-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2003; 285(-6-):H2516-H2523. >>> Aldosterone; benzamil; CSF, artificial; CSF/CNS; Rat; 2ML2; 14 days; Cardiovascular.

P5857 Wotus,C., Engeland,W.C. Differential regulation of adrenal corticosteroids after restriction-induced drinking in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-1-):R183-R191. >>> Aldosterone; Propylene glycol; SC; Rat; ; Controls received mp w/ vehicle; replacement therapy (adrenalectomy).

R0157 Burlew,B.S., Weber,K.T. Cardiac fibrosis as a cause of diastolic dysfunction. Herz 2002; 27(--):92-98. >>> Aldosterone; Saline; Ethanol; SC; Mice; 1007D; ; Controls received mp w/ vehicle; aldosterone plasma levels checked at the end of the experiment; replacement thrapy (adrenalectomy); dose-response (p.1192); comparison of sc injections vs. mp; pumps replaced every 7 days; 2% ethanol in vehicle used.

P5394 Kalman,B.A., Spencer,R.L. Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain. Endocrinology 2002; 143(-11-):4184-4195. >>> Aldosterone; RU-28362; Propylene glycol; SC; Rat; 2001; 5 days; Replacement therapy (adrenalectomy); agents infused together in the same pump or in separate pumps.

P5170 Knepper,Mark A., Beutler,Kathleen, Masilamani,Shyama, Nielsen,Jakob, Nielsen,Soren, Wang,Xiao Yan  American Journal of Physiology 2002/4; 282(-4 Part 2-):F577-F584. >>> Aldosterone; Candesartan; SC; Rat; 2ML2; 2 or 4 days; Controls received mp w/ vehicle; candesartan is an Angiotensin II type 1 receptor blocker; animals received aldosterone for 4 days or candesartan for 2 days.

P6144 Kwon,T.H., Nielsen,J., Masilamani,S., Hager,H., Knepper,M.A., Frokiaer,J., Nielsen,S. Regulation of collecting duct AQP3 expression: response to mineralocor ticoid. American Journal of Physiology-Renal Physiology 2002; 283(-6-):F1403-F1421. >>> Aldosterone; dexamethasone; DMSO; saline; SC; Rat; 2002; 10 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P6707 Lacolley,P., Labat,C., Pujol,A., Delcayre,C., Benetos,A., Safar,M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats. Circulation 2002; 106(-22-):2848-2853. >>> Aldosterone; Rat; 4 weeks; Replacement therapy (uninephrectomy); no stress (see pg.2849); cardiovascular.

P5429 Nielsen,J., Kwon,T.H., Masilamani,S., Beutler,K., Hager,H., Nielsen,S., Knepper,M.A. Sodium transporter abundance profiling in kidney: effect of spironolactone. American Journal of Physiology-Renal Physiology 2002; 283(-5-):F923-F933. >>> Dexamethasome; aldosterone, D-; DMSO; saline, sterile; SC; Rat; 2002; 10 days; Replacement therapy (adrenalectomy).

P5841 Ohara,M., Cadnapaphornchai,M.A., Summer,S.N., Falk,S., Yang,J.H., Togawa,T., Schrier,R.W. Effect of mineralocorticoid deficiency on ion and urea transporters and aquaporin water channels in the rat. Biochemical and Biophysical Research Communications 2002; 299(-2-):285-290. >>> Aldosterone; IP; Rat; 2ML4; 9 days; Functionality of mp verified by aldosterone plasma levels; replacement therapy (adrenalectomy).

P5096 Ornellas,D.S., Nascimento,D.S., Christoph,D.H., Guggino,W.B., Morales,M.M. Aldosterone and high-NaCl diet modulate ClC-2 chloride channel gene expression in rat kidney. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2002; 444(--):193-201. >>> Aldosterone; rat; 2001; 48 hours; controls received sham surgery; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy p. 194);.

P5216 Park,J.B., Schiffrin,E.L. Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused r ats: Role of endothelin-1. American Journal of Hypertension 2002; 15(--):164-169. >>> Aldosterone; Saline; SC; Rat; 2002; 6 weeks; Controls received mp w/ vehicle; pumps replaced every 2 weeks; cardiovascular.

P6590 Rocha,R., Martin-Berger,C.L., Yang,P.C., Scherrer,R., Delyani,J., McMahon,E. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 2002; 143(-12-):4828-4836. >>> Angiotensin II; aldosterone, D-; Saline; ethanol; SC; Rat; 2004; 3 weeks; Controls received mp w/ vehicle (saline); functionality of mp verified by plasma levels; replacement therapy (adrenalectomy); cardiovascular; peptides; 2% ethanol for d-aldo.

P5419 Rocha,R., Rudolph,A.E., Frierdich,G.E., Nachowiak,D.A., Kekec,B.K., Blomme,E.A.G., McMahon,E.G., Delyani,J.A. Aldosterone induces a vascular inflammatory phenotype in the rat heart. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-5-):H1802-H1810. >>> Aldosterone, D-; Propylene glycol; ethanol; water, distilled; SC; Rat; 2002; 1, 2, or 4 weeks; Controls received mp w/ vehicle; cardiovascular; vehicle consisted of 87% PG, 9% ethanol and 4% d H20.

P5475 Shade,R.E., Blair-West,J.R., Carey,K.D., Madden,L.J., Weisinger,R.S., Denton,D.A. Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1070-R1078. >>> Angiotensin II; aldosterone; Saline; ethanol; SC; CSF/CNS; Monkey (baboon); 49 days; Controls received mp w/ vehicle; long-term study, pumps replaced every 7 days (6 times); angiotensin II diluted in saline and infused ICV; aldosterone diluted in 10% ethanol in saline and infused SC; some animals implanted w/ 2 pumps.

P6719 Sun,Y., Zhang,J.K., Lu,L., Chen,S.S., Quinn,M.T., Weber,K.T. Aldosterone-induced inflammation in the rat heart - Role of oxidative stress. American Journal of Pathology 2002; 161(-5-):1773-1781. >>> Aldosterone; Rat; 3,4,5 weeks; Controls received no treatment/unoperated; replacement therapy (uninephrectomy); cardiovascular.

P5416 Tostes,R.C.A., Touyz,R.M., He,G., Chen,X., Schiffrin,E.L. Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clinical Science 2002; 103(-Suppl. 48-):25S-30S. >>> Aldosterone; Saline; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle.

P5211 van Acker,S.A., Oitzl,M.S., Fluttert,M.F., de Kloet,E.R. Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone. J Neuroendocrinol. 2002/1; 14(-1-):56-63. >>> Aldosterone; IP; Rat; 2002; 10 days; Functionality verified by aldosterone plasma levels; replacement therapy (adrenalectomy); cardiovascular; antihypertensive;.

P5617 Virdis,A., Neves,M.F., Amiri,F., Viel,E., Touyz,R.M., Schiffrin,E.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 2002; 40(-4-):504-510. >>> Angiotensin II; Aldosterone, d-; Saline; SC; Rat; 2 weeks; Antihypertensive; aldosterone plasma levels measured..

P4939 Bailey,M.A., Unwin,R.J., Shirley,D.G. In vivo inhibition of renal 11-beta-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption. Clinical Science 2001; 101(--):195-198. >>> Aldosterone; Dexamethasone; SC; rat; 2002; 8-12; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy p.195); "the plasma concentration of aldosterone achieved via osmotic minipump is just suficient to maintain the rats in good health without causing over-stimulation." p. 197; mineralocorticoids.

P4929 Imai,H., Nishimura,T., Sadamatsu,M., Liu,Y., Kabuto,M., Kato,N. Type II glucocorticoid receptors are involved in neuronal death and astrocyte activation induced by trimethyltin in the rat hippocampus. Experimental Neurology 2001; 171(--):22-28. >>> Dexamethasone; Aldosterone; SC; rat; 21 days; controls received sham surgery; replacement therapy (adrenalectomy); corticosterone pellets also used;.

P4952 Park,J.B., Schiffrin,E.L. ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension 2001; 37(--):1444-1449. >>> Aldosterone; Saline; SC; rat; 2002; 6 weeks; controls received mp w/ vehicle; functionality of mp verified by systolic BP measurement; dose response (graph p. 1446); long-term study, pumps replaced every 2 weeks; cardiovascular; mineralocorticoid hypertension;.

P4890 Planas,J.M., Garriga,C., Planas,J.M., Moreto,M. Aldosterone mediates the changes in hexose transport induced by low sodium intake in chicken distal intestine. JOURNAL OF PHYSIOLOGY-LONDON 2001; 535(-1-):197-205. >>> Aldosterone; Propylene glycol; SC; Bird (chicken); 2002; 14 days; functionality of mp verified by serum aldosterone, renin levels; dose-response (fig 1 col 7 p. 535.1).

P4867 Wickman,A., Andersson,I.J.L., Jia,J., Hedin,L., Bergstrom,G. Endothelial nitric oxide synthase protein is reduced in the renal medulla of two-kidney, one-clip hypertensive rats. Journal of Hypertension 2001; 19(--):1665-1673. >>> Angiotensin II; Aldosterone; Saline; IP; rat; 7 days; controls received mp w/ vehicle; functionality of mp verified by mean arterial pressure, plasma aldosterone assay; dose response (text p. 1669); peptides; Angiotensin II given in first experiment, aldosterone administered in the second;.

P4041 Saito,T., Ishikawa,S.-E., Ando,F, Higashiyama,M, Nagasaka,S, Sasaki,S., Saito,T. Vasopressin-dependent upregulation of aquaporin-2 gene expression in glucocorticoid-deficient rats.. Am.J.Physiological.Renal Physiol. 2000; 279(--):F502-F508. >>> Aldosterone; Dexamethasone;; SC;; rat;; 2ML4;; 7 days;; Controls received mp with Aldosterone or Dexamethasone; replacement therapy (adrenalectomy); glucocorticoid;.

P5260 Shigaev,A., Asher,C., Latter,H., Garty,H., Reuveny,E. Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. Am.J Physiol Renal Physiol 2000/4; 278(-4-):F613-F619. >>> Aldosterone; PEG 300; SC; Rat; 2001; ; Funtionality verified by aldosterone plasma levels.