References on Angiogenesis Research Using ALZET® Osmotic Pumps

16293 Chen, L., Joseph, G., Zhang, F. F., Nguyen, H., Jiang, H., Gotlinger, K. H., Falck, J. R., Yang, J., Schwartzman, M. L., Guo, A. M. 20-HETE contributes to ischemia-induced angiogenesis. Vascul Pharmacol 2016; 83(--):57-65. >>> DDMS; 6,15-20-HEDGE; IM (hindlimb gracilis); Mice; 2002, 2004; Controls received mp w/ vehicle; animal info (Balb/c mice, 12 wk old); functionality of mp verified by blood pressure and blood perfusion scans; dose-response (pg. 61); good methods (pg. 58); ischemia (peripheral); tissue perfusion (intramuscular); Polyethylene catheter tubing used (inner ID 0.8 mm); Dose (5 mg/kg/day);.

16202 Liu, Y., Li, B., Wang, X., Li, G., Shang, R., Yang, J., Wang, J., Zhang, M., Chen, Y., Zhang, Y., Zhang, C., Hao, P. Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor. Mol Med 2015; 21(--):626-36. >>> Angiotensin (1-7), A779, PD123319; saline; SC; mice; Controls received mp w/ vehicle; animal info: Male BALB/c mice (6–8 wks old); functionality of mp verified by measurement of tumor volumes; cancer (Hepatocellular Carcinoma); peptides; Dose: (200 ng/kg/min) Ang-(1–7), (800 ng/kg/min) Ang-(1–7), (800 ng/kg/min) A779, (10 mg/kg/day) PD123319.

15999 Hongu, T., Funakoshi, Y., Fukuhara, S., Suzuki, T., Sakimoto, S., Takakura, N., Ema, M., Takahashi, S., Itoh, S., Kato, M., Hasegawa, H., Mochizuki, N., Kanaho, Y. Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial beta1 integrin recycling. Nat Commun 2015; 6(--):7925. >>> SecinH3; DMSO; glycerol; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (male, Arf6 flox/flox, 8 weeks old); pumps replaced every 4 days; 50% DMSO used; 50% glycerol; cancer (B16 melanoma or LLC); xenograft model;.

15823 Yi Shu&Bo Xiao&Qian Wu&Tiantian Liu&Yang Du&, Haiyun Tang&Si Chen&Li Feng&Lili Long&Yi Li  MOLECULAR NEUROBIOLOGY 2016; 53(--):561-576. >>> Ephrin-A5-Fc; immunoglobulin G2A; CSF, artificial; CSF/CNS (hippocampus); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6, 18-21g, 5-6 weeks old); ALZET brain infusion kit used; no stress (see pg. 563) All mice survived the operation, remained active, ate well, and appeared to be well groomed."; behavioral testing (seizure frequency); Cannula placement verified via histological analysis; pumps primed in 37C PBS overnight; used dentyl acrylic;.

15046 Morita, S., Furube, E., Mannari, T., Okuda, H., Tatsumi, K., Wanaka, A., Miyata, S., Miyata, S. Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain. CELL AND TISSUE RESEARCH 2015; 359(--):865-884. >>> AraC; Saline; CSF/CNS; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6J, adult, P70-P84); comparison of IP injection vs mp; cardiovascular;“This infusion method is effective for suppressing cell proliferation in the subventricular zone and minimizes surgery damage to brain tissues” pg 867;.

15011 Liu, J., Deng, G.H., Zhang, J., Wang, Y., Xia, X.Y., Luo, X.M., Deng, Y.T., He, S.S., Mao, Y.Y., Peng, X.C., Weil, Y.Q., Jiang, Y., Jiang, Y. The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models. PSYCHONEUROENDOCRINOLOGY 2015; 52(--):130-142. >>> Norepinephrine bitartrate hydrate; propranolol; Ascorbic acid; PBS; SC; Mice; 1004; Animal info (female, BALB/c, 5-7 weeks old); cancer (colorectal carcinoma, human);.

14969 Hu, J.Z., Zeng, L., Huang, J.H., Wang, G., Lu, H.B., Lu, H.B. miR-126 promotes angiogenesis and attenuates inflammation after contusion spinal cord injury in rats. BRAIN RESEARCH 2015; 1608(--):191-202. >>> miR-126; Saline; CSF/CNS (intrathecal); Rat; 1003D; Controls received mp w/ control agomir; animal info (male, Sprague Dawley, 180-220g); spinal cord injury; post op. care (Ringer's solution administered IP 5 ml, penicillin G 40000 U IM QD for 3 days, bladders manually expressed BID); behavioral testing (locomotor testing, open field); immunology; pumps primed overnight at 37C.

14953 Gutierrez, L.S., Ling, J., Nye, D., Papathomas, K., Dickinson, C., Gutierrez, L.S. Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model. WORLD JOURNAL OF GASTROENTEROLOGY 2015; 21(--):6157-6166. >>> ABG-898; Glucose, sterile; SC; Mice; Controls received mp w/ vehicle; animal info (WT or TSP-1 -/-); 5% glucose used; cardiovascular; immunology; peptides;.

14927 Escudero, P., Navarro, A., Ferrando, C., Furio, E., Gonzalez-Navarro, H., Juez, M., Sanz, M.J., Piqueras, L., Piqueras, L. Combined treatment with bexarotene and rosuvastatin reduces angiotensin-II-induced abdominal aortic aneurysm in apoE(-/-) mice and angiogenesis. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):2946-2960. >>> Angiotensin II; Saline; Mice; 2004; Controls received mp w/ vehicle; animal info (apoE -/-, 8 weeks old); cardiovascular; peptides;“Because the s.c. administration of the statin using an osmotic minipump allows 100% drug bioavailability and its p.o. administration results in 34.5% bioavailability in mice (Peng et al., 2009), we chose the former route to ensure a full dosage effect.” pg 2948;.

14926 Duan, Q.L., Yang, L., Gong, W., Chaugai, S., Wang, F., Chen, C., Wang, P.H., Zou, M.H., Wang, D.W., Wang, D.W. MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis. JOURNAL OF CELLULAR PHYSIOLOGY 2015; 230(--):1964-1973. >>> Isoproterenol hydrochloride; Mice; 1002; 1004; Controls received mp w/ saline; animal info (C57BL6); cardiovascular;.

14883 Chen, W.H., Mao, C.Q., Zhuo, L.L., Ong, J.L., Chen, W.H. Beta-nerve growth factor promotes neurogenesis and angiogenesis during the repair of bone defects. Neural Regeneration Research 2015; 10(--):1159-1165. >>> Nerve growth factor, b-; PBS; Evans blue dye; Bone (parietal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 250-300g); 1% Evans blue used; good methods (picture of dual cannula impmlantation pg 1161); Multiple pumps per animal (2); pump with agent inserted into right pocket, pump with PBS inserted into left pocket; bilateral infusion;.

14554 Minami, Y., Sasaki, T., Bochimoto, H., Kawabe, J., Endo, S., Hira, Y., Watanabe, T., Okumura, S., Hasebe, N., Ohsaki, Y., Sasaki, T. Prostaglandin 12 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis. INTERNATIONAL JOURNAL OF ONCOLOGY 2015; 46(--):548-554. >>> Betaprost sodium; SC; Mice; Controls received mp w/ water, distilled; animal info (female, C57BL6, 8-10 weeks old, 20-25g); cancer (lung); Betaprost sodium aka BPS; Betaprost sodium is a stable PGI2 analog;.

14528 Zhang, J.L., Yang, W.L., Hu, B.Q., Wu, W., Fallon, M.B., Fallon, M.B. Endothelin-1 Activation of the Endothelin B Receptor Modulates Pulmonary Endothelial CX3CL1 and Contributes to Pulmonary Angiogenesis in Experimental Hepatopulmonary Syndrome. American Journal of Pathology 2014; 184(--):1706-1714. >>> BQ788; Saline; IV (femoral); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); cardiovascular; BQ788 is a selective ETb receptor antagonist; common bile duct ligation;.

14473 Wang, X.W., Khaidakov, M., Guo, Z.K., Ding, Z.F., He, Q.Z., Mehta, J.L., Wang, X.W. LOX-1 Deletion Limits Cardiac Angiogenesis in Mice Given Angiotensin II. Cardiovascular Drugs and Therapy 2014; 28(--):441-446. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (LOX-1 KO or WT); cardiovascular; peptides; bp measured using tail cuff;.

14467 Wang, Y., Zhu, Y.D., Gui, Q., Wang, X.D., Zhu, Y.X., Wang, Y. Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice. GENETICS AND MOLECULAR RESEARCH 2014; 13(--):7173-7183. >>> Glucagon; Cetrimid solution; IP; Mice (nude); 1007D; Animal info (female, BALB/C nu/nu, 7 weeks old); functionality of mp verified by glycemia; cancer (lung); dose-response (pg 7179); cardiovascular;.

14346 Peshavariya, H.M., Liu, G.S., Chang, C.W.T., Jiang, F., Chan, E.C., Dusting, G.J., Peshavariya, H.M. Prostacyclin Signaling Boosts NADPH Oxidase 4 in the Endothelium Promoting Cytoprotection and Angiogenesis. ANTIOXIDANTS&REDOX SIGNALING 2014; 20(--):2710-2725. >>> Cicaprost; Saline; DMSO; tris; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6 6-8 weeks old); 25% DMSO used;.

14278 Lim, Y.C., Bhatt, M.P., Kwon, M.H., Park, D., Na, S., Kim, Y.M., Ha, K.S., Ha, K.S. Proinsulin C-Peptide Prevents Impaired Wound Healing by Activating Angiogenesis in Diabetes. Journal of Investigative Dermatology 2015; 135(--):269-278. >>> C-peptide; PBS; SC; Mice; 2004; Controls received sham surgery; animal info (male, C57BL6J, 6 weeks old, streptozotocin induced diabetes); cardiovascular; peptides; diabetes;.

14254 Lankhorst, S., Kappers, M.H.W., van Esch, J.H.M., Smedts, F.M.M., Sleijfer, S., Mathijssen, R.H.J., Baelde, H.J., Danser, A.H.J., van den Meiracker, A.H., van den Meiracker, A.H. Treatment of Hypertension and Renal Injury Induced by the Angiogenesis Inhibitor Sunitinib Preclinical Study. Hypertension 2014; 64(--):1282-U260. >>> Captopril; SC; Rat; 2ML2; Animal info (male, Wistar Kyoto, 280-300g); cardiovascular; antihypertensive; bp measured using radiotelemetry (DSI);.

13851 Loh, K.P., Ng, G., Yu, C.Y., Fhu, C., Yu, D.J., Vennekens, R., Nilius, B., Soong, T.W., Liao, P. TRPM4 inhibition promotes angiogenesis after ischemic stroke. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2014; 466(-3-):563-576. >>> RNA, small interfering TRPM inhibiting; IV (jugular); Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 300g); ischemia (cerebral); behavioral testing (rotarod apparatus); gene therapy; cardiovascular; TRPM4 aka transient receptor potential melastatin 4;.

13530 Hoh, B.L., Hosaka, K., Downes, D.P., Nowicki, K.W., Wilmer, E.N., Velat, G.J., Scott, E.W. Stromal cell derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls. Journal of Neurosurgery 2014; 120(-1-):73-86. >>> Angiotensin II; PBS; SC; Mice; Animal info (female, C57BL6, 6-8 weeks old, 20-25g); cardiovascular; immunology; petides.

13212 Seo, J.H., Yu, J.H., Suh, H., Kim, M.S., Cho, S.R. Fibroblast Growth Factor-2 Induced by Enriched Environment Enhances Angiogenesis and Motor Function in Chronic Hypoxic-Ischemic Brain Injury. PLoS One 2013; 8(-9-):U184-U194. >>> Antibody, fibroblast growth factor-2;; CSF/CNS; Mice; 1002; Animal Info. (Hypoxic-ischemic mice, 6 weeks old, CD-1); Pumps replaced (every 2 weeks); Ischemia (hypoxic ischemic brain injury); Behavior testing (Rotarod performance, forelimb-use asymmetry test, grip strength test).

13166 Zhang, G.D., Panigrahy, D., Mahakian, L.M., Yang, J., Liu, J.Y., Lee, K.S.S., Wettersten, H.I., Ulu, A., Hu, X.W., Tam, S., Hwang, S.H., Ingham, E.S., Kieran, M.W., Weiss, R.H., Ferrara, K.W., Hammock, B.D. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2013; 110(-16-):6530-6535. >>> Epoxy Decosapentaenoic acid; epoxide hydrolase, soluble;; PEG 400; DMSO; SC; Mice; 1002; Dose-response (Fig. 1A); 50% DMSO used; 50% PEG 400 used; Epoxy Decosapentaenoic acid (19, 20-DEP); epoxide hydrolase inhibitor (EHi);.

13065 Guan, A.L., Gong, H., Ye, Y., Jia, J.G., Zhang, G.P., Li, B.Y., Yang, C.J., Qian, S.L., Sun, A.J., Chen, R.Z., Ge, J.B., Zou, Y.Z. Regulation of p53 by Jagged1 Contributes to Angiotensin II-Induced Impairment of Myocardial Angiogenesis. PLoS One 2013; 8(-10-):U644-U656. >>> Angiotensin II; SC; Mice; Animal info (C57BL/6, male, 8 wks old); peptides.

12996 Talasila, K.M., Soentgerath, A., Euskirchen, P., Rosland, G.V., Wang, J., Huszthy, P.C., Prestegarden, L., Skaftnesmo, K.O., Sakariassen, P.O., Eskilsson, E., Stieber, D., Keunen, O., Brekka, N., Moen, I., Nigro, J.M., Vintermyr, O.K., Lund-Johansen, M., Niclou, S., Mork, S.J., Enger, P.O., Bjerkvig, R., Miletic, H. EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica 2013; 125(-5-):683-698. >>> Cetuximab; CSF/CNS (intratumoral); Rat (nude); 2ML4; Control animals received mp w/ PBS; animal info (rnu/rnu Rowett); ALZET brain infusion kit 2 used; convection enhanced delivery (CED); tissue perfusion (intratumoral).

12720 Menon, J., Doebele, R.C., Gomes, S., Bevilacqua, E., Reindl, K.M., Rosner, M.R. A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer. PLoS One 2012; 7(-11-):U770-U779. >>> 8CPT; H-89; SC; Mice; 2004; Control animals received mp w/ PBS; animal info (male, athymic, 15-20 g, 4-6 wks old); 8CPT also known as 8-pCPT-2'-O-Me-cAMP; enzyme inhibitor (PKA); cancer (prostate).

12693 Yoshioka, K., Yoshida, K., Cui, H., Wakayama, T., Takuwa, N., Okamoto, Y., Du, W., Qi, X., Asanuma, K., Sugihara, K., Aki, S., Miyazawa, H., Biswas, K., Nagakura, C., Ueno, M., Iseki, S., Schwartz, R.J., Okamoto, H., Sasaki, T., Matsui, O., Asano, M., Adams, R.H., Takakura, N., Takuwa, Y. Endothelial PI3K-C2alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nature Medicine 2012; 18(-10-):1560-U170. >>> Angiotensin II; SC; Mice; 1002; Animal info (Pik3c2a -/-, 12 wks old, male); peptides.

12691 Muramatsu, R., Takahashi, C., Miyake, S., Fujimura, H., Mochizuki, H., Yamashita, T. Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin. Nature Medicine 2012; 18(-11-):1658-1U93. >>> CAY10441; iloprost; Saline; CSF/CNS (intrathecal); Mice; 1002; 1004; Control animals received mp w/ vehicle; animal info (SLJ/L, female).

12418 Jing, X.F., Miwa, H., Sawada, T., Nakanishi, I., Kondo, T., Miyajima, M., Sakaguchi, K. Ephrin-A1-Mediated Dopaminergic Neurogenesis and Angiogenesis in a Rat Model of Parkinson's Disease. PLoS One 2012; 7(-2-):U1066-U1079. >>> Ephrin-A1-fc; CSF/CNS; Rat; 1007D; Controls received mp w/ clustered IgG-Fc; animal info (Sprague Dawley, 7-9 wks old).

12362 Miyazaki, R., Ichiki, T., Hashimoto, T., Ikeda, J., Kamiharaguchi, A., Narabayashi, E., Matsuura, H., Takeda, K., Sunagawa, K. Acetyleholinesterase inhibitors attenuate angiogenesis. Clinical Science 2012; 123(-3-4-):241-249. >>> Physostigmine; Mice; Animal info (C57BL/6, 9 wks old); enzyme inhibitor (acetylcholinesterase); hindlimb ischemia.

12090 Thau-Zuchman, O., Shohami, E., Alexandrovich, A.G., Leker, R.R. SUBACUTE TREATMENT WITH VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER TRAUMATIC BRAIN INJURY INCREASES ANGIOGENESIS AND GLIOGENESIS. Neuroscience 2012; 202(-;-):334-341. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; Controls received mp w/ vehicle; animal info (adult, Sabra, 40 g).

12056 Albertsson, P., Lennernaes, B., Norrby, K. Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis. APMIS 2012; 120(-2-):147-156. >>> Irinotecan; mitoxantrone; Saline; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (Sprague Dawley, adult); chemotherapeutic;.

12012 Frontini, M.J., Nong, Z.X., Gros, R., Drangova, M., O'Neil, C., Rahman, M.N., Akawi, O., Yin, H., Ellis, C.G., Pickering, J.G. Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells. NATURE BIOTECHNOLOGY 2011; 29(-5-):421-U232. >>> Fibroblast growth factor-9; PBS; IA (femoral); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 9-10 mo old); polyethylene tubing used; ischemia (hind limb).

11993 Malla, R.R., Gopinath, S., Gondi, C.S., Alapati, K., Dinh, D.H., Gujrati, M., Rao, J.S. Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma. Cancer Gene Therapy 2011; 18(-6-):419-434. >>> Cathepsin B; vector, scrambled; Mice (nude); 1002; Animal info (athymic, nu/nu, 5-7 wks old).

11930 Khan, A.A., Dace, D.S., Ryazanov, A.G., Kelly, J., Apte, R.S. Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase-Regulated Pathway. American Journal of Pathology 2010; 177(-1-):481-492. >>> Resveratrol; Sirt1 inhibitor III; NH125; Ethanol; SC; Mice; Controls received mp w/ vehicle; animal info (C57BL/6, eFK2 -/-); 25% ethanol used.

11926 Thau-Zuchman, O., Shohami, E., Alexandrovich, A.G., Leker, R.R. Combination of Vascular Endothelial and Fibroblast Growth Factor 2 for Induction of Neurogenesis and Angiogenesis after Traumatic Brain Injury. Journal of Molecular Neuroscience 2012; 47(-1-):166-172. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, Sabra, adult, 40 g).

11875 Passam, F.H., Qi, J.C., Tanaka, K., Matthaei, K.I., Krilis, S.A. In vivo modulation of angiogenesis by beta 2 glycoprotein I. Journal of Autoimmunity 2010; 35(-3-):232-240. >>> Glycoprotein I, beta 2; SC; Mice; Controls received mp w/ saline; animal info (129/Sv/C57BL/6, beta 2GP1 -/-, wt, 10 wks old); 200 ul sized pump used; cancer.

11728 Li, J.Y., Su, C.H., Wu, Y.J., Tien, T.Y., Hsieh, C.L., Chen, C.H., Tseng, Y.M., Shi, G.Y., Wu, H.L., Tsai, C.H., Lin, F.Y., Yeh, H.I. Therapeutic Angiogenesis of Human Early Endothelial Progenitor Cells Is Enhanced by Thrombomodulin. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-11-):2518-U403. >>> TMD23; IV; Mice (nude); 2ML4; Controls received mp w/ PBS; animal info (BALB/c, female, athymic, nude, 18-22 g, 8 wks old); incorrectly listed Model 2ML4 for use in mice; TMD23 also known as thrombomodulin domains 2 and 3.

11603 Soleimani, R., Heytens, E., Oktay, K. Enhancement of Neoangiogenesis and Follicle Survival by Sphingosine-1-Phosphate in Human Ovarian Tissue Xenotransplants. PLoS One 2011; 6(-4-):U2019-U2026. >>> Sphingosine-1-Phosphate; Saline; SC; Mice (SCID); 2001D; Controls received mp w/ vehicle; animal info (SCID).

11479 Liang, G., Butterfield, C., Liang, J.W., Birsner, A., Folkman, J., Shing, Y. Beta-35 is a transferrin-derived inhibitor of angiogenesis and tumor growth. Biochemical and Biophysical Research Communications 2011; 409(-3-):562-566. >>> Beta-35; IP; Mice (SCID); Controls received mp w/ vehicle; animal info (male, 24-27 g); pumps replaced every 7 days; cancer (pancreatic, melanoma); Beta-35 is an angiogenesis inhibitor.

11439 Kioi, M., Vogel, H., Schultz, G., Hoffman, R.M., Harsh, G.R., Brown, J.M. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. Journal of Clinical Investigation 2010; 120(-3-):694-705. >>> AMD 3100; Mice (nude); Animal info (athymic, nu/nu); cancer;"An important feature of our data is that although we completed the drug infusion before the tumors were eradicated, the tumors continued to shrink and did not recur even long after the end of the infusion."pg 702.

11437 Kim, J., Koyanagi, T., Mochly-Rosen, D. PKC delta Activation Mediates Angiogenesis via NADPH Oxidase Activity in PC-3 Prostate Cancer Cells. PROSTATE 2011; 71(-9-):946-954. >>> V1-1, delta; RACK, delta omega; Saline; Mice (nude); 2001; Controls received mp w/ TAT carrier peptide; animal info (6 wks old, male, nu/nu); peptides; pumps replaced after 2 weeks; cancer (prostate); half-life, 2 weeks in the pump (p. 947); deltaV1-1 is a PKC delta-selective inhibitor; delta gamma RACK is a PKC delta selective activator.

11379 Gupta, R., Nalla, A.K., Gogineni, V.R., Chetty, C., Bhoopathi, P., Klopfenstein, J.D., Tsung, A.J., Mohanam, S., Rao, J.S. uPAR/Cathepsin B Overexpression Reverse Angiogenesis by Rescuing FAK Phosphorylation in uPAR/Cathepsin B Down Regulated Meningioma. PLoS One 2011; 6(-2-):U298-U308. >>> Plasmid, pCU, pU2, FluPAR/Cathepsin B; Mice (nude); Controls received mp w/ control plasmid pSV; animal info (athymic, nu/nu, female, 5-7 wks old); cancer (meningioma).

11314 Durando, M., Kass, L., Perdomo, V., Bosquiazzo, V.L., Luque, E.H., Munoz-de-Toro, M. Prenatal exposure to bisphenol A promotes angiogenesis and alters steroid-mediated responses in the mammary glands of cycling rats. Journal of Steroid Biochemistry and Molecular Biology 2011; 127(-1-2-):35-43. >>> Bisphenol A; DMSO; SC; Rat; 1002; Controls received mp w/ vehicle; animal info (female, 3 mo old, Wistar); 50% DMSO used.

11041 Leker, R.R., Toth, Z.E., Shahar, T., Cassiani-Ingoni, R., Szalayova, I., Key, S., Bratincsak, A., Mezey, E. TRANSFORMING GROWTH FACTOR alpha INDUCES ANGIOGENESIS AND NEUROGENESIS FOLLOWING STROKE. Neuroscience 2009; 163(-1-):233-243. >>> Transforming growth factor, alpha; CSF, artificial; CSF/CNS (infarct border); Mice; 1002; Controls received mp w/ vehicle; animal info (C57B, male, 4-6 wks old).

11008 Leksa, V., Loewe, R., Binder, B., Schiller, H.B., Eckerstorfer, P., Forster, F., Soler-Cardona, A., Ondrovicova, G., Kutejova, E., Steinhuber, E., Breuss, J., Drach, J., Petzelbauer, P., Binder, B.R., Stockinger, H. Soluble M6P/IGF2R Released by TACE Controls Angiogenesis via Blocking Plasminogen Activation. Circulation Research 2011; 108(-6-):676-U323. >>> Peptide (18-36); scrambled peptide; SC; Mice (SCID); 1002; Animal info (pathogen-free, 6 wks old, female, CB17, scid/scid); peptides; cancer; angiogenesis.


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What researchers are saying...

“The infusion treatment using implanted ALZET-type osmotic mini-pumps proved to be superior to both S.C. and I.V. infusion applied twice a day for 2 weeks.” (p. 586) Szende et al., Anti-Cancer Drugs 2003;14:585-588.