References on the Administration of Antioxidants Using ALZET® Osmotic Pumps

1. AEOL 10150

8662 Rabbani, Z.N., Batinic-Haberle, I., Anscher, M.S., Huang, J., Day, B.J., Alexander, E., Dewhirst, M.W., Vujaskovic, Z. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2007; 67(-2-):573-580. >>> AEOL 10150; SC; Rat; 2002; Controls received mp w/ vehicle; functionality of mp verified by plasma AEOL 10150 concentrations; dose-response (fig. 4); long-term study; pumps replaced every 2 weeks; half-life (p. 574), short; cancer; animal info (female, Fisher-344, 150-170 grams);"Osmotic mini-pumps provided consistent and dose-dependent delivery of AEOL 10150,""a continuous availability of antioxidant via osmotic infusion pumps throughout the study."(p. 575).

5702 Bowler, R.P., Sheng, H.X., Enghild, J.J., Pearlstein, R.D., Warner, D.S., Crapo, J.D. A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free Radical Biology and Medicine 2002; 33(-8-):1141-1152. >>> AEOL 10150; PBS; IV (jugular); Mice; 1003D; Controls received mp w/ vehicle; AEOL 10150 is a catalytic antioxidant metalloporphyrin; ischemia (cerebral); MCAO.

5446 Sheng, H.X., Enghild, J.J., Bowler, R., Patel, M., Batinic-Haberle, I., Calvi, C.L., Day, B.J., Pearlstein, R.D., Crapo, J.D., Warner, D.S. Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free Radical Biology and Medicine 2002; 33(-7-):947-961. >>> AEOL 10150; PBS; IV (jugular); Mice; 1003D; Controls received mp w/ vehicle; plasma levels of AEOL 10150 determined by HPLC; ischemia (cerebral); MCAO.

top of page

2. Ascorbic Acid

8628 Maruyama, J., Yamagata, T., Ulfendahl, M., Bredberg, G., Altschuler, R.A., Miller, J.M. Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs. NEUROBIOLOGY OF DISEASE 2007; 25(-2-):309-318. >>> Trolox; neomycin; ascorbic acid; Perilymph, artificial; sodium bicarbonate; Ear (cochlea); Guinea-Pig; 2002; Controls received mp w/ vehicle; pumps replaced after 14 days; post op. care (doxycycline); animal info (male, pigmented, 250-400g., neomycin deafening); cannula primed with 10% neomycin solution followed by a small air bubble spacer to allow neomycin infusion for first 2 days; trolox, a vitamin F analogue, and ascorbic acid delivered together in 1 mp; tissue perfusion (cochlea).

2897 Keshet, G.I., Weinstock, M. Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal stress. Pharmacol. Biochem. Behav 1995; 50(-3-):413-419. >>> Ascorbic acid; Naltrexone; Saline; SC; rat (pregnant); rat; controls received mp w/ vehicle.

top of page

3. Bleomycin

Q2641 Stefanov,A.N., Fox,J., Haston,C.K. Positional Cloning Reveals Strain-Dependent Expression of Trim16 to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice. PLoS Genetics 2013; 9(-1-):U684-U691. >>> Bleomycin sulfate; Sodium chloride; SC; Mice; 2001; 7 days; Animal info (C57BL/6, C3H/HeJ, 8-10 wks old).

Q2444 Hamasaki,T., Suzuki,H., Shirohzu,H., Matsumoto,T., Alessandro-Gabazza,C.N., Gil-Bernabe,P., Boveda-Ruiz,D., Naito,M., Kobayashi,T., Toda,M., Mizutani,T., Taguchi,O., Morser,J., Eguchi,Y., Kuroda,M., Ochiya,T., Hayashi,H., Gabazza,E.C., Ohgi,T. Efficacy of a Novel Class of RNA Interference Therapeutic Agents. PLoS One 2012; 7(-8-):U207-U221. >>> Bleomycin; Saline, sterile; SC; Mice; 2001; ; Control animals received mp w/ saline; animal info (C57BL/6, male, 8 wks old, 20-22 g).

P9472 Zhou,Y., Koli,K., Hagood,J.S., Miao,M., Mavalli,M., Rifkin,D.B., Murphy-Ullrich,J.E. Latent Transforming Growth Factor-beta-Binding Protein-4 Regulates Transforming Growth Factor-beta 1 Bioavailability for Activation by Fibrogenic Lung Fibroblasts in Response to Bleomycin. American Journal of Pathology 2009; 174(-1-):21-33. >>> Bleomycin; SC; Mice; 2001; 8 days; Controls received mp w/ saline; animal info (female, C57BL/6, Thy-1 -/-, 8-10 wks old); lung fibrosis model.

P9040 Fujimoto,H., Alessandro-Gabazza,C.N., Palanki,M.S.S., Erdman,P.E., Takagi,T., Gabazza,E.C., Bruno,N.E., Yano,Y., Hayashi,T., Tamaki,S., Sumida,Y., Adachi,Y., Suzuki,K., Taguchi,O. Inhibition of nuclear factor-kappa B in T cells suppresses lung fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2007; 176(-12-):1251-1260. >>> Bleomycin; Saline; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; animal info (8-10 wks old, female, C57BL/6, 18-22 g.); bleomycin induced pulmonary fibrosis.

P9036 Azuma,M., Nishioka,Y., Aono,Y., Inayama,M., Makino,H., Kishi,J., Shono,M., Kinoshita,K., Uehara,H., Ogushi,F., Izumi,K., Sone,S. Role of alpha 1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2007; 176(-12-):1243-1250. >>> Bleomycin; Saline; SC; Mice; 2001; ; Controls received mp w/ vehicle; animal info (8 wks old, female, C57BL/6); bleomycin induced pulmonary fibrosis.

P8144 Gu,L., Zhu,Y.J., Yang,X., Guo,Z.J., Xu,W.B., Tian,X.L. Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacologica Sinica 2007; 28(-3-):382-391. >>> Bleomycin; Saline; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; functionality of mp verified by examination; no stress (see p.384); animal info (Smad 3 -/- or wt, 8-10 wks old, 17g. 27g.); lung fibrosis model.

P7882 Inayama,M., Nishioka,Y., Azuma,M., Muto,S., Aono,Y., Makino,H., Tani,K., Uehara,H., Izumi,K., Itai,A., Sone,S. A novel I kappa B kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006; 173(-9-):1016-1022. >>> Bleomycin; SC; Mice; 2001; ; Controls received mp w/ saline; animal info (female, C57BL/6, 8 wk old, 18g.).

P7713 Fujimoto,H., Gabazza,E.C., Taguchi,O., Nishii,Y., Nakahara,H., Bruno,N.E., Alessandro-Gabazza,C.N., Kasper,M., Yano,Y., Nagashima,M., Morser,J., Broze,G.J., Suzuki,K., Adachi,Y. Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced lung fibrosis. American Journal of Pathology 2006; 168(-4-):1086-1096. >>> Bleomycin; Saline; SC; Mice; 7 days; Controls received mp w/ vehicle; animal info (female, C57BL/6, 18-22 g); pulmonary.

P7407 Aono,Y., Nishioka,Y., Inayama,M., Ugai,M., Kishi,J., Uehara,H., Izumi,K., Sone,S. Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2005; 171(-11-):1279-1285. >>> Bleomycin; Saline; SC; Mice; 2001; 28 days; Controls received mp w/ vehicle; pumps replaced every 7 days; peptides; lung fibrosis induced by bleomycin.

P6658 Haston,C.K., Wang,M., Dejournett,R.E., Zhou,X.H., Ni,D., Gu,X.J., King,T.M., Weil,M.M., Newman,R.A., Amos,C.I., Travis,E.L. Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice. Human Molecular Genetics 2002; 11(-16-):1855-1863. >>> Bleomycin; SC; Mice; ; Minipump usage mentioned on p. 1860; pump model not listed.

P5586 Li,J., Ortiz,L.A., Hoyle,G.W. Lung pathology in platelet-derived growth factor transgenic mice: Effects of genetic background and fibrogenic agents. Experimental Lung Research 2002; 28(-6-):507-522. >>> Bleomycin; SC; mice; 7 days; controls received mp with saline.

P5168 Zhao,J.S., Shi,W., Wang,Y.L., Chen,H., Bringas,P.Jr, Datto,M.B., Frederick,J.P., Wang,X.F., Warburton,D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2002; 282(--):L585-L593. >>> Bleomycin sulfate; Saline; SC; Mice (knockout); 1007D; 7 days; Antibiotic; Controls received mp w/ vehicle; functionality of mp verified by residual volume.

P4668 Schwartz,D.R, Homanics,G.E, Hoyt,D.G., Klein,E, Abernethy,J, Lazo,J.S. The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance.. Proc.Natl.Acad.Sci. 1999; 96(--):4680-4685. >>> Bleomycin;; Saline;; SC;; rat;; 2001;; 7 days;; Antibiotic; Controls received mp w/ vehicle; cancer; peptides; bleomycin is a glycopeptide anticancer agent;.

P3397 Haston,C.K., Amos,C.I., King,T.M., Travis,E.L. Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse. Cancer Res. 1996; 56(--):2596-2601. >>> Bleomycin; Saline; SC; mice; 2001; no duration posted; Antibiotic; controls received mp w/saline; cancer; toxicology.

P2643 Bokemeyer,C., Ludwig,E., Reile,D., Harstrick,A., Poliwoda,H., Schmoll,H.J. Antitumor activity and toxicity of continuous infusion versus bolus administration of bleomycin in two heterotransplanted human testicular cancer cell lines. Oncology Reports 1995; 2(--):161-165. >>> Bleomycin; SC; mice (nude); 7 days; Antibiotic; comparison of bolus ip injections vs. mp; cancer; toxicology; ". . .bolus application of bleomycin is at least as active as continuous infusion. . .".

P2007 Rodgers,K.E., Girgis,W., diZerega,G.S. Effect of tolmetin sodium dihydrate on adhesion formation by intraperitoneal administration of antineoplastic agents. Cancer Chemother.Pharmacol. 1992; 29(--):248-251. >>> Doxorubicin HCl; Mitoxantrone; Tolmetin sodium; Bleomycin; Cisplatin; Methotrexate; PBS; IP; rat; 2ML1; 7 days; Antibiotic; cancer; no stress (see p249).

P1707 Kimler,B.F., Martin,D.F., Evans,R.G., Morantz,R.A., Vats,T.S. Combination of radiation therapy and intracranial bleomycin in the 9L rat brain tumor model. Int.J.Radiat.Oncol.Biol.Phys. 1990; 18(--):1115-1121. >>> Bleomycin; CSF/CNS (intratumoral); cattle; rat; 2001; 2002; 7, 14 days; Antibiotic; controls received pumps with saline only; tissue perfusion (tumor); dose-response (graph, p. 1117); comparison of ip injections vs. mp.

P1211 Vanuytsel,L., Feng,Y., Landuyt,W., Begg,A., Van der Schueren,E. Effect of simultaneous administration of bleomycin on the acute skin reactions of mice after single and fractionated doses of radiation. Int.J.Radiat.Oncol.Biol.Phys. 1988; 14(--):103-108. >>> Bleomycin; Saline; SC; mice; 7 days; Antibiotic; Pump model not stated; concomitant radiation treatment; antibiotic.

P1159 Harrison,J.H., Lazo,J.S. High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis. J.Pharmacol.Exp.Ther. 1987; 243(-3-):1185-1194. >>> Bleomycin; Saline; SC; mice; 2001; 1 week; Antibiotic; controls received mp w/ vehicle; C57BL/6, BALB/C mice used; author states mp superior for these experiments; comparison of bolus inject. vs. sc inject. vs. mp infusion; antibiotic.

P1037 Wahlberg,P., Wennerberg,J., Alm,P., Biorklund,A., Trope,C. The effect of continuous bleomycin infusion on the growth and cell kinetics of heterotransplanted squamous cell carcinoma of the head and neck. Anticancer Res. 1987; 7(--):55-58. >>> Bleomycin; Saline; SC; mice; 7 days; Antibiotic; controls received mp with vehicle; half-life data; mice implanted with SCC tumor; cancer therapy; comparison of ip injections vs. mp infusion.

P0493 Osieka,R., Glatte,P., Schmidt,C.-G. Continuous infusion versus intermittent bolus injection of bleomycin in a human embryonal testicular cancer xenograft. Cancer Treat.Rep. 1984; 68(-5-):799-801. >>> Bleomycin; Saline; IP; mice; 2001; 1 week; Antibiotic; comparison of daily intermittent ip injec vs. ip mp infusion; dose-response data; cancer chemotherapy.

P0458 Osieka,V.R. Continuous infusion vs. bolus injection of bleomycin in a human testicular cancer xenograft system. Arzneimittelforschung (German, English summary) 1984; 34(-4-):460-464. >>> Bleomycin; Saline; IP; mice; 2001; 1 week; Antibiotic; cancer therapy; dose range of 10.5-42 mg/kg bleomycin; comparison of daily injec vs. mp infusion; full text is printed in German.

P0383 Kato,T., Mizutani,M., Ota,K. Effect of peplomycin by continuous infusion on Ehrlich carcinoma. Jpn.J.Cancer Chemother. 1983; 10(-3-):763-767. >>> Peplomycin; Bleomycin; IP; mice; 2001; 1 week; Antibiotic; comparison of daily and intermittent injec. vs. mp infusion; cancer chemotherapy.

P0075 Peng,Y.-M., Alberts,D.S., Chen,H.S., Mason,N., Moon,T.E. Antitumour activity and plasma kinetics of bleomycin by continuous and intermittent administration. Br.J.Cancer 1980; 41(-4-):644-647. >>> Bleomycin; Saline; IP; mice; 6 days; Antibiotic; intermittent bolus injection ip vs. infusion; cancer.

P0017 Sikic,B.I., Collins,J.M., Mimnaugh,E.G., Gram,T.E. Improved therapeutic index of bleomycin when administered by continuous infusion in mice. Cancer Treat.Rep. 1978; 62(-12-):2011-2017. >>> Bleomycin; Saline; SC; Mice; 7,14 days; Comparison of bolus injections vs. SC minipump; study #1 infused for 7 days and study #2 infused for 14 days; cancer (lung carcinoma); peptides.

top of page

4. Catalase

13758 DiStasi, M.R., Unthank, J.L., Miller, S.J., Miller, S.J. Nox2 and p47(phox) modulate compensatory growth of primary collateral arteries. American Journal of Physiology-Heart and Circulatory Physiology 2014; 306(--):U56-U64. >>> Peptide, Nox2ds-tat; polyethylene glycol-conjugated catalase; SC; Rat; mice; 2ML1; 1002; Controls received mp w/ scramble ds-tat or vehicle; animal info (Rat male, Wister-Kyoto, 2-3 months; mice male, C57Bl6J and p47 phox -/-, 4.5-6 months old); cardiovascular; peptides; polyethylene glycol-conjugated catalase aka PEG-CAT; arterial ligation; NOX2 is NADPH oxidase;.

4310 Shimoda, K., Nomura, M., Kato, M. Effect of antioxidants, anti-inflammatory drugs, and histamine antagonists on Sparfloxacin-induced phototoxicity in mice. Fundam. Appl. Toxicol 1996; 31(--):133-140. >>> Catalase; Dimethyl sulfoxide; Dexamethasone; Indomethacin; Pyrilamine maleate; AA-861; Cimetidine; Phenidone; Ethanol; Saline; SC; mice; 1007D; all agents infused concomitantly in the same pump; preliminary study conducted to test solubility and toxicity for 5 days; enzyme inhibitors; toxicology.

3223 Truelove, D., Shuaib, A., Ijaz, S., Richardson, S., Kalra, J. Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults. Neurochem. Res 1994; 19(-6-):665-671. >>> Tempol; catalase; CSF/CNS; Gerbil; 1007D; Controls received mp with saline; agents given separately and together; ischemia (cerebral).

2608 Macdonald, R.L., Weir, B.K.A., Runzer, T.D., Grace, M.G.A., Poznansky, M.J. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 1992; 30(-4-):529-539. >>> Catalase; tempol; CSF/CNS (spinal cord, intrathecal); monkey; 2ML1; controls received inactivated SOD and BSA; functionality of mp verified by measuring enzyme levels in CSF during infusion and testing agent released from pump in vitro for 7 days; stability verified by measuring activity of enzymes released from pumps in vitro over 7 days; daily CSF sampling performed using a subcutaneous Ommaya reservoir; authors report no cases of catheter blockage or dislodgement.

1927 Hattori, T., Ito, M., Suzuki, Y. Changes in intra-renal scavenging enzymes activities of the reactive oxygen species in experimental glomerulo-nephritis and nephrosis in rats. Nippon Jinzo Gakkai Shi 1991; 33(-2-):191-199. >>> Glutathione peroxidase; Catalase; tempol; rat; Japanese with English abstract.

1738 Mossman, B.T., Marsh, J.P., Sesko, A., Hill, S., Shatos, M.A., Doherty, J., Petruska, J., Adler, K.B., Hemenway, D., Mickey, R., Vacek, P., Kagan, E. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am. Rev. Respir. Dis 1990; 141(--):1266-1271. >>> Catalase; tempol; PBS; SC; rat; 2ML4; functionality of mp verified by serum catalase; PEG-conjugated enzymes; antioxidants; stability of enzymes questioned beyond 20 days.

1099 Mossman, B.T., Marsh, J.P., Hardwick, D., Gilbert, R., Hill, S., Sesko, A., Shatos, M., Doherty, J., Weller, A., Bergeron, M. Approaches to prevention of asbestos-induced lung disease using polyethylene glycol (PEG) - congugated catalase. J. Free Radicals in Biology&Medicine 1986; 2(--):335-338. >>> Catalase, PEG-; Saline, balanced; rat; 2ML4; controls received surgery but no mp; dose response; 3 doses of agent infused.

top of page

5. Dimethylthiourea

4920 Wolf, G., Wenzel, U., Hannken, T., Stahl, R.A.K. Angiotensin II induces p27Kip1 expression in renal tubules in vivo: role of reactive oxygen species.. JOURNAL OF MOLECULAR MEDICINE 2001; 79(--):382-389. >>> Angiotensin II; Dimethylthiourea;; PBS;; IP;; rat;; 2002;; Controls received mp w/ vehicle; cardiovascular; peptides; Dimethylthiourea, also called DMTU, is an antioxidant; some animals received 2 pumps (IP): one pump for ANG II infusion and one for DMTU infusion;.

top of page

6. EUK-189

11864 Peng, J., Oo, M.L., Andersen, J.K. Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration. Journal of Neurochemistry 2010; 115(-6-):1363-1373. >>> EUK-189; Mannitol; SC; Mice (transgenic); 2004; Controls received mp w/ vehicle; animal info (alpha synuclein A53T Tg).

10400 Clausen, A., Doctrow, S., Baudry, M. Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice. NEUROBIOLOGY OF AGING 2010; 31(-3-):425-433. >>> EUK-189; EUK-207; Mannitol; SC; Mice; 2004; Controls received mp w/ vehicle; long-term study; pumps replaced every 28 days; animal info (C57BL/6N Sim, 27-36 g, 17 months old).

9872 Peng, J., Stevenson, F.F., Oo, M.L., Andersen, J.K. Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation. Free Radical Biology and Medicine 2009; 46(-2-):312-320. >>> EUK-189; Mannitol; SC; Mice; 2004; Controls received mp w/vehicle; animal info (C57BL/6, 2-12 months old); neurodegenerative (Parkinson's disease).

8273 Tocco, G., Illigens, B.M.W., Malfroy, B., Benichou, G. Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species. Cellular Immunology 2006; 241(-2-):59-65. >>> EUK-189; Mice; Animal info (female, 6-8 weeks old, BALB/C and C57BL/6).

8014 Zhang, H.J., Doctrow, S.R., Oberley, L.W., Kregel, K.C. Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging. Journal of Applied Physiology 2006; 100(-4-):1385-1391. >>> EUK-189; Water, distilled; SC; Rat; 2004; Controls received mp w/ vehicle; functionality of mp verified by residual volume; animal info (male, Fischer 344, 6 month old, 300-400g., 24 month old, 350-450g.).

7446 Peng, J., Stevenson, F.F., Doctrow, S.R., Andersen, J.K. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra - Implications for Parkinson disease. Journal of Biological Chemistry 2005; 280(-32-):29194-29198. >>> EUK-189; Mannitol; SC; Mice; 2004; Controls received mp w/ vehicle; neurodegenerative (Parkinson's disease).

6667 Browne, S.E., Roberts, LJ II, Dennery, P.A., Doctrow, S.R., Beal, M.F., Barlow, C., Levine, R.L. Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radical Biology and Medicine 2004; 36(-7-):938-942. >>> EUK-189; Mannitol; SC; Mice; 2004; Controls received mp w/ vehicle; long-term study; pumps replaced every 28 days; no stress (see pg.941); cancer (thymoma); EUK-189 is a synthetic catalytic antioxidant w/ both catalase&superoxide dismutase activities; neurodegenerative (ataxia telangiectasia).

6096 Liu, R.L., Liu, I.Y., Bi, X.N., Thompson, R.F., Doctrow, S.R., Malfroy, B., Baudry, M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O F AMERICA 2003; 100(-14-):8526-8531. >>> EUK-189; EUK-207; Mannitol; water; SC; Mice; 2004; Controls received mp w/ vehicle; long-term study; pumps replaced every 28 days in same location; pumps primed for>40 hours in 5% mannitol; eukarion is a synthetic catalytic scavenger of reactive oxygen species; stress/adverse reaction: in 10% of mice, the pumps were replaced on the other side of hip area due to skin damage of original site of implantation; behavioral study.

top of page

7. Ebselen

15801 Esteban A.Moya,, Paulina Arias,, Carlos Varela,, María P. Oyarce, Rodrigo Del Rio,, Rodrigo Iturriaga. Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. Oxidative Medicine and Cellular Longevity 2016; 2016(--):1-9. >>> Ebselen; DMSO; saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200g); 80% DMSO used; cardiovascular; bp measured with radiotelemetry; Dose (10 mg/kg/day);.

12552 Park, J.G., Yoo, J.Y., Jeong, S.J., Choi, J.H., Lee, M.R., Lee, M.N., Lee, J.H., Kim, H.C., Jo, H., Yu, D.Y., Kang, S.W., Rhee, S.G., Lee, M.H., Oh, G.T. Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice. Circulation Research 2011; 109(-7-):739-U80. >>> Ebselen; DMSO; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (8 wks old, Prdx -/-, ApoE -/-); 80% DMSO used.

11973 Willett, N.J., Kundu, K., Knight, S.F., Dikalov, S., Murthy, N., Taylor, W.R. Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress. ANTIOXIDANTS&REDOX SIGNALING 2011; 15(-5-):1369-1378. >>> Tempol; ebselen; DMSO; saline; SC; IV (jugular); Mice; 2ML1; 1007D; Animal info (male, 11-13 wks old, C57BL/6, P47 phox -/-); 50% DMSO used.

6820 Khatri, J.J., Johnson, C., Magid, R., Lessner, S.M., Laude, K.M., Dikalov, S.I., Harrison, D.G., Sung, H.J., Rong, Y., Galis, Z.S. Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma. Circulation 2004; 109(-4-):520-525. >>> Ebselen; DMSO; SC; Mice (transgenic); Controls received mp w/ vehicle; cardiovascular; 50% DMSO; ebselen is a glutathione peroxidase-mimetic antioxidant (a.k.a Harmokisane).

top of page

8. Genistein

13624 Shi, R.F., Wang, S.L., Qi, X., Chen, S., Chen, P.J., Zhang, Q.G. Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats. NEUROCHEMISTRY INTERNATIONAL 2014; 65(-;-):14-22. >>> Genistein; DMSO; water, distilled; SC; Rat; 1002; Controls received mp w/ vehicle; animal info (female, ovarectomized); 50% DMSO used; ischemia (cerebral); cardiovascular;.

13141 Cortina, B., Torregrosa, G., Castello-Ruiz, M., Burguete, M.C., Moscardo, A., Latorre, A., Salom, J.B., Valles, J., Santos, M.T., Alborch, E. Improvement of the circulatory function partially accounts for the neuroprotective action of the phytoestrogen genistein in experimental ischemic stroke. European Journal of Pharmacology 2013; 708(-1-3-):88-94. >>> Genistein; Cyclodextrin, hydroxypropyl beta; IP; Rat; 2ML1; Control animals received mp w/ vehicle; animal info (Wistar, male, 300-350 g).

top of page

9. Glutathione

10690 Colombani, A.L., Carneiro, L., Benani, A., Galinier, A., Jaillard, T., Duparc, T., Offer, G., Lorsignol, A., Magnan, C., Casteilla, L., Penicaud, L., Leloup, C. Enhanced Hypothalamic Glucose Sensing in Obesity: Alteration of Redox Signaling. Diabetes 2009; 58(-10-):2189-2197. >>> Glutathione; CSF/CNS (third ventricle); Rat; 1003D; Controls received mp w/PBS-HEPES; animal info (obese, lean, male, Zucker, 7 wks old); cannula placement verified by angiogensin II dipsogenic effect; Plastics One cannula used; no stress (see pg 2193)"Well being of the animals (weight gain and food intake) was preserved during the infusion"; good methods.

10061 Fernandez, A., Llacuna, L., Fernandez-Checa, J.C., Colell, A. Mitochondrial Cholesterol Loading Exacerbates Amyloid-beta Peptide-Induced Inflammation and Neurotoxicity. Journal of Neuroscience 2009; 29(-20-):6394-6405. >>> Amyloid protein, beta (1-42), human oligomeric; lipoprotein, high density; glutathione ethyl ester; HEPES; CSF/CNS; Mice (transgenic); 1004; Controls received mp w/ vehicle; animal info (Tg-SREBP-2, NPC1-/-, Tg-APP/PS1); neurodegenerative (Alzheimer's Disease).

9876 Irwin, D.C., McCord, J.M., Nozik-Grayck, E., Beckly, G., Foreman, B., Sullivan, T., White, M., Crossno, JT Jr, Bailey, D., Flores, S.C., Majka, S., Klemm, D., van Patot, M.C.T. A potential role for reactive oxygen species and the HIF-1-alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radical Biology and Medicine 2009; 47(-1-):55-61. >>> Ascorbate; glutathione; tocopherol, alpha-; SC; Mice; 1007D; Controls received mp w/saline; animal info (male, C57BL/6J, 25-30g, 10-12 weeks old); compounds were mixed and infused together as an antioxodant cocktail.

9041 Li, L.H., Qin, H.Z., Shi, W.Q., Gao, G.D. Local Nogo-66 administration reduces neuropathic pain after sciatic nerve transection in rat. Neuroscience Letters 2007; 424(-3-):145-148. >>> Glutathione S-transferase; glutathione S-transferase-Nogo-66; CSF/CNS (sciatic nerve); Rat; 2002; Controls received mp w/ GST or no treatment; peptides; animal info (male, Sprague Dawley, 240-260g., Sciatic nerve transection); pain; silicon tube used.

8860 Powell, JA Jr, Mousa, S.A. Neutrophil-Activating Protein-2- and Interieukin-8-Mediated Angiogenesis. Journal of Cellular Biochemistry 2007; 102(-2-):412-420. >>> Fibroblast growth factor-2, basic, human; penicillamine, S-nitroso N-acetyl; glutathione, S-nitroso N-acetyl; SC; Mice; Peptides; animal info (male, C57BL/6, 6-8 wks old); SNAP and SNAG are nitric oxide donors.

8632 Zeevalk, G.D., Manzino, L., Sonsalla, P.K., Bernard, L.P. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson's disease. Experimental Neurology 2007; 203(-2-):512-520. >>> Glutathione, monoethyl ester; MPP+; Saline; SC; CSF/CNS; Rat; 2ML4; Controls received mp w/ vehicle; dose-response (fig. 6); stability verified by incubation for 0-28 days at 37 celsius, assessed by HPLC; half-life (pg. 515) 10-14 hours in culture; brain tissue distribution; toxicology; animal info (Sprague-Dawley, 300g.); neurodegenerative (Parkinson's disease).

top of page

10. Magnolol

6275 Chen, J.H., Wu, C.C., Hsiao, G., Yen, M.H. Magnolol induces apoptosis in vascular smooth muscle. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2003; 368(-2-):127-133. >>> Magnolol; Alcohol; SC; Rat; 2001; Dose-response (p. 129); pumps replaced every 7 days; magnolol, an active component purified from magnolia officinalis, is a commonly used chinese medicinal herb, with reported anti-inflammatory and antioxidant effects.

top of page

11. Mannitol

6592 Barcia, J.A., Castillo, A., Gutierrez, R., Gallego, J.M., Ortiz, L., Hernandez, M.E. Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat. Epilepsy Research 2004; 58(-1-):19-26. >>> Aminobutyric acid, Y-; mannitol; Saline; CSF/CNS (amygdala); Rat; 2001; Controls received mp w/mannitol; functionality of mp verified by cutting open&visual inspection; dose-response (table 1); no stress (see pg. 25).

5821 Chelikh, L., Teixeira, M., Martin, C., Sterkers, O., Ferrary, E., Couloigner, V. High variability of perilymphatic entry of neutral molecules through the round window. Acta Oto-laryngologica 2003; 123(-2-):199-202. >>> Mannitol; Inulin;; Radio-isotopes; 3H tracer; saline; ethanol; Ear (round window); Guinea-pig; 1007D; Tissue perfusion (round window).

4802 Bittner, B, Thelly, Th, Isel, H, Mountfield, R.J. The impact of co-solvents and the composition of experimental formulations on the pump rate of the ALZET®osmotic pump.. International Journal of Pharmaceutics 2000; 205(--):195-198. >>> Mannitol; Radio-isotopes; Pyrrolidone, N-methyl-2-; Propylene glycol; PEG; 14C tracer; Water; Dimethylacetamide; in vitro; 2ML1; Functionality of mp verified by in vitro testing; ALZAID chemical compatibility kit used; various solvents employed to find compatibility with drug reservoir.

top of page

12. Melatonin

14726 Eifert, A.W., Wilson, M.E., Vonnahme, K.A., Camacho, L.E., Borowicz, P.P., Redmer, D.A., Romero, S., Dorsam, S., Haring, J., Lemley, C.O., Lemley, C.O. Effect of melatonin or maternal nutrient restriction on vascularity and cell proliferation in the ovine placenta. ANIMAL REPRODUCTION SCIENCE 2015; 153(--):13-21. >>> Melatonin; luzindole; DMSO; water; Intrauterine; Sheep (ewe; pregnant); 2ML4; Controls received mp w/ vehicle; animal info (female, Western white face, GD62); functionality of mp verified by serum levels; 45% DMSO used; good methods (pg 15); no stress (see pg. 15); post op. care (BID IM injection flunixin meglumine; QD IP injection Penicillin G Procaine); teratology; cardiovascular; used 20 cm of PE 60 tubing; pumps primed overnight 37C saline with catheters;.

13406 Lemley, C.O., Camacho, L.E., Vonnahme, K.A. Uterine Infusion of Melatonin or Melatonin Receptor Antagonist Alters Ovine Feto-Placental Hemodynamics During Midgestation. Biology of Reproduction 2013; 89(-2-):U24-U32. >>> Melatonin; Luzindole; DMSO; water; Intrauterine (uterine horn); Sheep (ewe); 2ML4; Controls received mp w/ vehicle; functionality of mp verified by serum levels of melatonin taken; 45% DMSO used; stress/adverse reaction: (see pg.2); post op. care (For two days: flunixin meglumine 50 mg/ml IM twice a day; Penicillin G procain 300,000 u/ml once per day); tissue perfusion (uterus mesometrium); cardiovascular;.

12350 Bas, E., Van de Water, T.R., Gupta, C., Dinh, J., Vu, L., Martinez-Soriano, F., Lainez, J.M., Marco, J. Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses. British Journal of Pharmacology 2012; 166(-6-):1888-1904. >>> Gentamicin; dexamethasone; melatonin; Ear (round window); Rat; 2001; Controls received mp w/ saline; animal info (Wistar, male, 220-250 g); stability verified after 7 days (data not shown).

10761 Prendergast, B.J. MT1 Melatonin Receptors Mediate Somatic, Behavioral, and Reproductive Neuroendocrine Responses to Photoperiod and Melatonin in Siberian Hamsters (Phodopus sungorus). Endocrinology 2010; 151(-2-):714-721. >>> Melatonin; ramelteon; Saline; ethanol; SC; Hamster; 2004; Controls received mp w/ vehicle; long-term study; pumps replaced after 4 weeks; animal info (Siberian, adult, male); 15% ethanol used; ramelteon is a specific MT1/MT2 agonist.

top of page

13. MitoTEMPO

16269 Vendrov, A. E., Vendrov, K. C., Smith, A., Yuan, J., Sumida, A., Robidoux, J., Runge, M. S., Madamanchi, N. R. NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease. Antioxid Redox Signal 2015; 23(-18-):1389-409. >>> MitoTEMPO; SC; mice; 1004; animal info (13mo Apoe-/ - mice); functionality of mp verified by ECG; pumps replaced every 4 weeks; cardiovascular; antihypertensive; isoflurane/O2 anesthesia; Dose (1500 ug/kg/d);.

16024 Hoshino, A., Okawa, Y., Ariyoshi, M., Kaimoto, S., Uchihashi, M., Fukai, K., Iwai-Kanai, E., Matoba, S. Oxidative post-translational modifications develop LONP1 dysfunction in pressure overload heart failure. Circ Heart Fail 2014; 7(-3-):500-9. >>> MitoTEMPO; MG132; Epoxomicin; IP; mice; 1002; Controls received sham operation; animal info (mice); cardiovascular; study of heart failure; enzyme inhibitors; MG132 is a cell-permeable protease and proteasome inhibitor (target, LONP1); epoxomicin a selective proteasome inhibitor; Dose: MitoTEMPO (700 ug/kg/day), MG132 (720 ug/kg/day), epoxomicin (500 ug/kg/day).

14230 Jaffer, O.A., Carter, A.B., Sanders, P.N., Dibbern, M.E., Winters, C.J., Murthy, S., Ryan, A.J., Rokita, A.G., Prasad, A.M., Zabner, J., Kline, J.N., Grumbach, I.M., Anderson, M.E., Anderson, M.E. Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-beta-Mediated Collagen Production in a Murine Asthma Model. American Journal of Respiratory Cell and Molecular Biology 2015; 52(--):106-115. >>> MitoTEMPO; Saline; Mice; Controls received mp w/ vehicle; animal info (B6D2, 6-8 weeks old);.

13750 Daehn, I., Casalena, G., Zhang, T.R., Shi, S.L., Fenninger, F., Barasch, N., Yu, L.P., D'Agati, V., Schlondorff, D., Kriz, W., Haraldsson, B., Bottinger, E.P., Bottinger, E.P. Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. Journal of Clinical Investigation 2014; 124(--):1608-1621. >>> MitoTEMPO; BQ-123; Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, BALB/c); BQ123 is EDN1/EDNRA-specific peptide antagonist; MitoTEMPO is a mitochondria-targeted antioxidant.

13376 Gentle, M.E., Shi, S.L., Daehn, I., Zhang, T.R., Qi, H.Y., Yu, L.P., D'Agati, V.D., Schlondorff, D.O., Bottinger, E.P. Epithelial Cell TGFbeta Signaling Induces Acute Tubular Injury and Interstitial Inflammation. Journal of the American Society of Nephrology 2013; 24(-5-):787-799. >>> MitoTEMPO; Saline; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (Pax8-rtTA/TetO-TBRI(ADD) hybrid); comparison of subcutaneous injection vs mp"Similar results were seen with mini-pumps and subcutaneous injection."pg 796; immunology;.

12760 Luo, M., Guan, X.Q., Luczak, E.D., Lang, D., Kutschke, W., Gao, Z., Yang, J.Y., Glynn, P., Sossalla, S., Swaminathan, P.D., Weiss, R.M., Yang, B.L., Rokita, A.G., Maier, L.S., Efimov, I.R., Hund, T.J., Anderson, M.A. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. Journal of Clinical Investigation 2013; 123(-3-):1262-1274. >>> MitoTEMPO; SC; Mice; 1004; Animal info (Ncf 1 -/-; 3-5 mo old); MitoTEMPO is a mitochondrial targeted antioxidant; diabetes.

top of page

14. N-acetylcysteine

15913 Karalija, A., Novikova, L. N., Kingham, P. J., Wiberg, M., Novikov, L. N. The effects of N-acetyl-cysteine and acetyl-L-carnitine on neural survival, neuroinflammation and regeneration following spinal cord injury. Neuroscience 2014; 269(--):143-51. >>> L- N-acetyl-cysteine; O-acetyl-L-canitine; saline; Intrathecal; rats; 2002; Controls received mp w/ vehicle; animal info (adult, 10-12 week female Sprague-Dawley rats); pumps replaced every 2 weeks; spinal cord injury; stab wound in dorsal root entry zone of C3 spinal cervical segment; post op. care (given analgesic Finadyne, normal saline, and benzylpenicillin; each animal housed alone); Peptides ALC, NAC; NAC aka N-Acetyl-cysteine; ALC aka acetyl-L-carnitine; Dose: 2.4 mg/day for NAC, 0.9 mg/day for ALC.

13829 Karalija, A., Novikova, L.N., Kingham, P.J., Wiberg, M., Novikov, L.N., Karalija, A. THE EFFECTS OF N-ACETYL-CYSTEINE AND ACETYL-L-CARNITINE ON NEURAL SURVIVAL, NEUROINFLAMMATION AND REGENERATION FOLLOWING SPINAL CORD INJURY. Neuroscience 2014; 269(--):143-151. >>> N-acetyl-cysteine ; acetyl-l-carnitine hydrochloride; Saline; CSF/CNS (intrathecal); Rat; 2002; Animal info (female, Sprague Dawley, 10-12 weeks); pumps replaced every 14 days; good methods (p144); spinal cord injury;.

13639 Gonzalez, G.E., Rhaleb, N.E., Nakagawa, P., Liao, T.D., Liu, Y.H., Leung, P., Dai, X.G., Yang, X.P., Carretero, O.A. N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats. Clinical Science 2014; 126(-1-2-):85-94. >>> Angiotensin II; peptide, N-acetyl-seryl-aspartyl-lysyl-proline;; Saline; acetic acid; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Lewis, 240-320g); cardiovascular; immunology; peptides; N-acetyl-seryl-aspartyl-lysyl-proline aka Ac-SDKP; bp measured using radiotelemetry (DSI);.

12480 Karalija, A., Novikova, L.N., Kingham, P.J., Wiberg, M., Novikov, L.N. Neuroprotective Effects of N-Acetyl-Cysteine and Acetyl-L-Carnitine after Spinal Cord Injury in Adult Rats. PLoS One 2012; 7(-7-):U674-U684. >>> Acetyl-cysteine, N-, stereoisomer; acetyl-L-carnitine hydrochloride, O-; CSF/CNS (intrathecal, subarachnoid space); Rat; 2002; Animal info (Sprague Dawley, female, 10-12 wks old);"(catheter) was fixed to the S1 vertebral bone by HistoacrylH glue, and secured to the back muscles by several sutures."pg e41086; PE-60 tubing used; spinal cord injury.

11931 Chang, J.L., Li, Y.M., Huang, Y., Lam, K.S.L., Hoo, R.L.C., Wong, W.T., Cheng, K.K.Y., Wang, Y.Q., Vanhoutte, P.M., Xu, A.M. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16(INK4A) Signaling Pathway. Diabetes 2010; 59(-11-):2949-2959. >>> Adiponectin, recomb.; acetylcysteine, N-; SC; Mice; Controls received mp w/ vehicle; animal info (20 wks old, 8 wks old, male, adiponectin KO, wt); N-acetylcysteine, also known as NAC, is an antioxidant.

top of page

15. Rapamycin

Q2380 Paliouras,G.N., Hamilton,L.K., Aumont,A., Joppe,S.E., Barnabe-Heider,F., Fernandes,K.J.L. Mammalian Target of Rapamycin Signaling Is a Key Regulator of the Transit-Amplifying Progenitor Pool in the Adult and Aging Forebrain. Journal of Neuroscience 2012; 32(-43-):15012-15026. >>> Rapamycin; epidermal growth factor; DMSO; CSF/CNS; Mice (pregnant); 1007D; 7 days; Control animals received mp w/ vehicle; animal info (C57BL/6, female, 2, 10, 18 mo old); ALZET brain infusion kit 3 used.

Q2046 Klucken,J., Poehler,A.M., Ebrahimi-Fakhari,D., Schneider,J., Nuber,S., Rockenstein,E., Schloetzer-Schrehardt,U., Hyman,B.T., McLean,P.J., Masliah,E., Winkler,J. Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway. Autophagy 2012; 8(-5-):754-766. >>> Bafilomycin, A1; rapamycin; CSF/CNS; Mice; 1007D; 2 weeks; Animal info (wt, alpha synuclein, 9 mo old); neurodegenerative (Parkinson's disease).

Q1974 Yang,S.B., Tien,A.C., Boddupalli,G., Xu,A.W., Jan,Y.N., Jan,L.Y. Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons. Neuron 2012; 75(-3-):425-436. >>> Rapamycin; PEG 400; DMSO; cremophor; CSF/CNS; Mice; 1004; ; Animal info (C57BL/6, 2, 12 mo old); ALZET brain infusion kit used; 10% DMSO used; 60% PEG 400 used; 30% cremophor used.

Q0824 Phornphutkul,C., Lee,M., Voigt,C., Wu,K.Y., Ehrlich,M.G., Gruppuso,P.A., Chen,Q. The Effect of Rapamycin on Bone Growth in Rabbits. Journal of Orthopaedic Research 2009; 27(-9-):1157-1161. >>> Rapamycin; DMSO; Bone (proximal tibial growth plates); Rabbit; 2004; 8 weeks; Controls received mp w/ vehicle; animal info (5 wks old, New Zealand White); long-term study; pumps replaced after 4 weeks; 5% DMSO used; good methods pg 1158.

Q0610 Chan,C.-C., Martin,D.F., Xu,D., Roberge,F.G. Side Effects of Rapamycin in the Rat. Journal of Ocular Pharmacology 1995; 11(-2-):177-181. >>> Rapamycin; PEG 400; Tween 80; dimethylacetamide, N, N; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Lewis, 8-12 wks old).

Q0508 Wang,C.Y., Kim,H.H., Hiroi,Y., Sawada,N., Salomone,S., Benjamin,L.E., Walsh,K., Moskowitz,M.A., Liao,J.K. Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR. Science Signaling 2009; 2(-62-):U8-U18. >>> Rapamycin; SC; Mice; 4 weeks; Controls received mp w/ vehicle; animal info (Akt1 null).

Q0461 Bridle,K.R., Popa,C., Morgan,M.L., Sobbe,A.L., Clouston,A.D., Fletcher,L.M., Crawford,D.H.G. Rapamycin Inhibits Hepatic Fibrosis in Rats by Attenuating Multiple Profibrogenic Pathways. LIVER TRANSPLANTATION 2009; 15(-10-):1315-1324. >>> Rapamycin; DMSO; PEG 400; SC; Rat; 21 days; Controls received mp w/ vehicle; animal info (normal, male, Wistar, 450-550 g, 214-320 g).

Q0422 Qi,S.H., Mizuno,M., Yonezawa,K., Nawa,H., Takei,N. Activation of mammalian target of rapamycin signaling in spatial learning. NEUROSCIENCE RESEARCH 2010; 68(-2-):88-93. >>> Rapamycin; DMSO; saline; CSF/CNS (third ventricle); Rat; ; Controls received mp w/ vehicle; animal info (male, Wistar, 2-3 months old); 0.5 ul/hr pump used; behavioral testing (Radial-arm maze task).

Q0084 Crews,L., Spencer,B., Desplats,P., Patrick,C., Paulino,A., Rockenstein,E., Hansen,L., Adame,A., Galasko,D., Masliah,E. Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of alpha-Synucleinopathy. PLoS One 2010; 5(-2-):U163-U178. >>> Rapamycin; CSF/CNS; Mice; 1007D; 2 weeks; Controls received mp w/ vehicle; cyanoacrylate adhesive; animal info (alpha-syn, Tg); neurodegenerative (dementia with Lewy bodies, Parkinson's Disease).

P9753 Buckmaster,P.S., Ingram,E.A., Wen,X.L. Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy. Journal of Neuroscience 2009; 29(-25-):8259-8269. >>> Rapamycin; DMSO; ethanol; fluorescein; CSF/CNS (dentate gyrus); Rat; 2004; 1-2 months; Controls received mp w/vehicle; functionality of mp verified by fluorescein labeling; long-term study; pumps replaced after 1 month; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley, 34 days old); 50% DMSO used; 15% ethanol used.

P8737 Addy,N.A., Fornasiero,E.F., Stevens,T.R., Taylor,J.R., Picciotto,M.R. Role of calcineurin in nicotine-mediated locomotor sensitization. Journal of Neuroscience 2007; 27(-32-):8571-8580. >>> Cyclosporin; FK-506; rapamycin; PBS; Tween 20; DMSO; ethanol; cremaphor; CSF/CNS (ventral tegmental area); CSF/CNS (nucleus accumbens); Rat; 2004; 3-4 weeks; Controls received mp w/ vehicle; no stress (see pg. 8573); animal info (male, Sprague-Dawley, 200-250g); 25% DMSO.

P7922 Segrelles,C., Moral,M., Lara,M.F., Ruiz,S., Santos,M., Leis,H., Garcia-Escudero,R., Martinez-Cruz,A.B., Martinez-Palacio,J., Hernandez,P., Ballestin,C., Paramio,J.M. Molecular determinants of Akt-induced keratinocyte transformation. ONCOGENE 2006; 25(-8-):1174-1185. >>> Rapamycin; PBS; BSA; SC; Mice (nude); 2002; 2 weeks; Cancer; animal info (nude, 5-6 weeks old, female).

P7354 Krahe,T.E., Medina,A.E., De Bittencourt-Navarrete,R.E., Colello,R.J., Ramoa,A.S. Protein synthesis-independent plasticity mediates rapid and precise recovery of deprived eye responses. Neuron 2005; 48(-2-):329-343. >>> Cycloheximide; rapamycin; tetrodotoxin; PBS; Ferret; 4 days; Controls received mp w/ vehicle; 0.25 ul model pump used.

P7287 Guba,M., Koehl,G.E., Neppl,E., Doenecke,A., Steinbauer,M., Schlitt,H.J., Jauch,K.W., Geissler,E.K. Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer. TRANSPLANT INTERNATIONAL 2005; 18(-1-):89-94. >>> Rapamycin; DMSO; IP; Mice; 2002; 7-35 days; Controls received mp w/ vehicle; comparison of IP injections vs. mp; cancer (colon adenocarcinoma); "The most effective inhibition of tumor growth occurred in rapamycin-treated mice on the continuous pumping system.;" "Survival data also show the most positive effect with continuous drug delivery." P. 91.

P4566 Luo,H., Chen,H., Qi,S, Loh,D., Daloze,P., Veillette,A, Xu,D., Wu,J. De novo-developed T cells have compromised response to existing alloantigens: Using Ld-specific transgenic 2C T cells as tracers in a mouse heart transplantation model. The Journal of Immunology 1998; 161(--):73-82. >>> Rapamycin; IP; Mice; 14 days;; Immunology; heart transplantation.

P3996 Thompson,P., Xu,D., Brunette,I., Chen,H. Combined effect of rapamycin and cyclosporine in the prevention of rat corneal allograft rejection. Transplant.Proc. 1998; 30(--):1033-1035. >>> Rapamycin; Tween 80; IV (lumbar); rat; 2002; 14 days; transplantation; dose-response (p. 1034); immunology.

P3363 Tu,Y., Stepkowski,S.M., Chou,T.-C., Kahan,B.D. The synergistic effects of cyclosporine, sirolimus, and brequinar on heart allograft survival in mice. Transplantation 1995; 59(-2-):177-183. >>> Cyclosporin A; Rapamycin; Cremophor; Dimethylacetamide, N, N-; Tween 80; PEG 400; IV (jugular); mice; 1007D; 7, 14 days; pumps replaced after 7 days; immunology; CSA and rapamycin given singly and via same pump.

P3156 Chen,H.F., Wu,J.P., Luo,H.Y., Daloze,P.M. Reversal of ongoing rejection of allografts by rapamycin. Transplant.Proc. 1991; 23(-4-):2241-2242. >>> Rapamycin; Tween; Dimethylacetamide, N-N-; PEG 400; IV (lumbar); rat; 14 days; immunology.

P3013 Di Joseph,J.F., Russo,R.J., Cochran,D.W. Osmotic pump delivery of rapamycin. Transplantation 1993; 55(-2-):450-452. >>> Rapamycin; Dimethylacetamide, N, N-; Tween 80; PEG 400; in vitro; 2002; 2 weeks; stability verified by in vitro testing and HPLC for 14 days; in vitro validation of functionality and rapamycin stability.

P2508 Ferraresso,M., Tian,L., Ghobrial,R., Stepkowski,R., Kahan,B.D. Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart allografts in rats. J.Immunol. 1994; 153(--):3307-3318. >>> Rapamycin; Dimethylacetamide, N, N-; PEG 400; Tween 80; IV (lumbar); rat; 2002; 14 days; immunology; serum from rats treated with RAPA via minipumps used to inoculate secondary recipients.

P2417 Roberge,F.G., Xu,D., Chan,C.-C., de Smet,M.D., Nussenblatt,R.B., Chen,H. Treatment of autoimmune uveoretinitis in the rat with rapamycin, an inhibitor of lymphocyte growth factor signal transduction. Curr.Eye Res. 1993; 12(-2-):197-203. >>> Rapamycin; PEG 400; Tween 80; Dimethylacetamide, N, N-; IV (lumbar); rat; 2002; 14 days; Immunology.

P2309 Hamashima,T., Yoshimura,N., Ohsaka,Y., Oka,T., Stepkowski,S.M., Kahan,B.D. In vivo use of rapamycin suppresses neither IL-2 production nor IL-2 receptor expression in rat transplant model. Transplant.Proc. 1993; 25(-1-):723-724. >>> Rapamycin; IV (lumbar); rat; 7 days; Immunology.

P2289 Chen,H.J., Xu,D., Luo,H., Daloze,P.M. Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by rapamycin. Transplantation 1993; 56(-3-):661-666. >>> Rapamycin; DMA; PEG 400; Tween 80; IV (lumbar); Rat; 2002; 14 days; Immunology.

P2264 Ferraresso,M., Ghobrial,R., Stepkowski,S.M., Kahan,B.D. The mechanism of unresponsiveness to allografts induced by rapamycin and rapamycin/cyclosporine treatment in rats. Transplantation 1993; 55(-4-):888-894. >>> Cyclosporin; Rapamycin; Cremophor; Dimethylacetamide; Ethanol; PEG 400; Tween 80; IV (lumbar); rat; 2002; 14 days; immunology.

P2246 DiJoseph,J.F., Mihatsch,M.J., Sehgal,S.N. Influence of rat strain on rapamycin's kidney effects. Transplant.Proc. 1993; 25(-1-):714-715. >>> Cyclosporin A; Rapamycin; Cremophor; Dimethylacetamide; Ethanol; PEG 400; Tween; IV (jugular); rat; 2002; 2 weeks; controls received mp w/vehicle; functionality of mp verified by HPLC analysis; immunology.

P2245 Daloze,P.J., Chen,H., Luo,H., Xu,D., Shan,X., Wu,J. Rapamycin's long-term effects on humoral and cellular immune responses in the rat. Transplant.Proc. 1993; 25(-1-):721-722. >>> Rapamycin; PEG; IV (lumbar); rat; 28 days; controls received mp w/PEG; pumps replaced at day 14; immunology.

P2229 Chen,H., Wu,J., Xu,D., Luo,H., Daloze,P. Rapamycin reverses acute heart, kidney, and pancreas allograft rejection and prevents accelerated heart allograft rejection in the rat. Transplant.Proc. 1993; 25(-1-):719-720. >>> Rapamycin; Dimethylacetamide, N, N-; PEG 400; Tween; IV; rat; 2002; 14,28 days; controls received mp w/vehicle; immunology.

P2228 Chen,H., Wu,J., Luo,H., Daloze,P. Synergistic effect of rapamycin and cyclosporine in pancreaticoduodenal transplantation in the rat. Transplant.Proc. 1992; 24(-3-):892-893. >>> Rapamycin; IV (lumbar); rat; 14 days; immunology.

P2048 Stepkowski,S.M., Tu,Y., Condon,T.P., Bennett,C.F. Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities. J.Immunol. 1994; 153(--):5336-5346. >>> Oligodeoxynucleotide, phosphorothioate antisense; Cyclosporin A; Rapamycin; Oligodeoxynucleotide, scrambled; Cremophor; Tween 80; Dimethylacetamide, N, N-; PEG 400; IV (jugular); mice; 7,14 days; oligo of interest was IP-3082; controls received no treatment, unrelated oligo IP-1082, or scrambled oligo IP-4189; immunology; "...this study reports the first example of pharmacologic activity of an antisense PS-oligo by i.v. systemic administration in a model of a complex inflammatory process".

P2016 Stepkowski,S.M., Chen,H.F., Wang,M.E., Daloze,P., Kahan,B.D. Inhibition of host-versus-graft and graft-versus-host responses after small bowel transplantation in rats by rapamycin. Transplantation 1992; 53(-2-):258-264. >>> Cyclosporin; Rapamycin; Dimethylacetamide; PEG 400; Tween; IV (lumbar); rat; 2002; 14 days; tissue perfusion (allograft); immunology.

P2015 Stepkowski,S.M., Chen,H., Daloze,P., Kahan,B.D. Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat. Transplantation 1991; 51(-1-):22-26. >>> Rapamycin; Dimethylacetamide; PEG 400; Tween 80; IA (innominate); IV (lumbar); rat; 2002; 14 days; tissue perfusion (allograft).

top of page

16. Resveratrol

16197 Lee, H. J., Lim, Y., Yang, S. J. Involvement of resveratrol in crosstalk between adipokine adiponectin and hepatokine fetuin-A in vivo and in vitro. J Nutr Biochem 2015; 26(-11-):1254-60. >>> Resveratrol; DMSO; SC; mice; 1004; Controls received mp w/ vehicle; animal info: Male, 6-week-old C57BL/6J mice; %50 of DMSO; dose-response (pg.1257-1259); Resveratrol aka RSV; Animals fed high-fat diets concurrently; Dose: 8 mg/kg/day.

14588 Kanavi, M.R., Darjatmoko, S., Wang, S.J., Azari, A.A., Farnoodian, M., Kenealey, J.D., van Ginkel, P.R., Albert, D.M., Sheibani, N., Polans, A.S., Polans, A.S. The Sustained Delivery of Resveratrol or a Defined Grape Powder Inhibits New Blood Vessel Formation in a Mouse Model of Choroidal Neovascularization. MOLECULES 2014; 19(--):17578-17603. >>> Resveratrol; DMSO; ethanol; SC; Mice; 2002; Control animals received mp w/ vehicle; animal info (6 wks old, female, C57BL/6J); 50% DMSO used; 15% ethanol used;"Owing to the limited compatibility of the osmotic pumps with DMSO and/or ethanol, as well as the limited solubility of resveratrol in aqueous solutions, it wasn't possible to achieve higher doses of resveratrol using osmotic pumps"pg 17585.

13951 Yang, S.J., Lim, Y., Yang, S.J. Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation. METABOLISM-CLINICAL AND EXPERIMENTAL 2014; 63(--):693-701. >>> Resveratrol; DMSO; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57BL6); 50% DMSO used; no stress (see pg. 697); diabetes;"Resveratrol was administered via an osmotic pump, which is a safe and standard delivery system for rodents""no side effects were observed by monitoring weight change, behavior and inflammatory response around the implantation area."pg 697;.

13450 Sheu, S.J., Liu, N.C., Ou, C.C., Bee, Y.S., Chen, S.C., Lin, H.C., Chan, J.Y.H. Resveratrol Stimulates Mitochondrial Bioenergetics to Protect Retinal Pigment Epithelial Cells From Oxidative Damage. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2013; 54(-9-):6426-6438. >>> Resveratrol; Coenzyme Q10; DMSO; IP; Rat; 2004; Controls received mp w/ vehicle or sham surgery; animal info (Female, Brown Norway, 200-265g); 0.8% DMSO used; post op. care (Procaine penicillin 1000 IU IM); Coenzyme Q10 aka ubiquinone;.

12805 Kanamori, H., Takemura, G., Goto, K., Tsujimoto, A., Ogino, A., Takeyama, T., Kawaguchi, T., Watanabe, T., Morishita, K., Kawasaki, M., Mikami, A., Fujiwara, T., Fujiwara, H., Seishima, M., Minatoguchi, S. Resveratrol Reverses Remodeling in Hearts with Large, Old Myocardial Infarctions through Enhanced Autophagy-Activating AMP Kinase Pathway. American Journal of Pathology 2013; 182(-3-):701-713. >>> Resveratrol; chloroquine; SC; Mice; Control animals received mp w/ vehicle; animal info (C57BL/6J, male, 8-10 wks old).

top of page

17. Retinoic Acid

7460 Liu, T., Bohlken, A., Kuljaca, S., Lee, M., Nguyen, T., Smith, S., Cheung, B., Norris, M.D., Haber, M., Holloway, A.J., Bowtell, D.D.L., Marshall, G.M. The retinoid anticancer signal: mechanisms of target gene regulation. British Journal of Cancer 2005; 93(-3-):310-318. >>> Retinoic acid, 13-cis-; Ethanol; SC; Mice (transgenic); 1007D; Controls received mp w/ vehicle; dose-response (fig. 1); no stress (see pg. 312-13); cancer (neuroblastoma).

7442 Karam, S.M., John, R., Alpers, D.H., Ponery, A.S. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23(-3-):433-441. >>> Retinoic acid; uridine, bromodeoxy-; SC; Mice; Controls received mp w/ vehicle; comparison of SC injections vs. mp; cancer (gastric); multiple pumps per animal (2).

4849 Kopke, R.D, Jackson, R.L, Li, G, Rasmussen, M.D, Hoffer, M.E, Frenz, D.A, Costello, M, Schultheiss, P, Van De Water, T.R. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function.. PNAS 2001; 98(-10-):5886-5891. >>> Transforming growth factor; insulin-like growth factor I; retinoic acid; brain-derived neurotrophic factor;; PBS; BSA;; Ear (vestibule); Guinea-pig; 2002; Controls received mp w/ vehicle; pumps replaced after 2 weeks; peptides; IntraEAR catheter used; GFI group pumps filled with TGF, IGF and Retinoic acid; GFII group pumps filled with TGF, IGF, BDNF and retinoic acid; tissue perfusion (vestibule).

15534 Rodgers, K.E., Girgis, W., Amand, K.St., Campeau, J.D., diZerega, G.S. Reduction of adhesion formation by intraperitoneal administration of various anti-inflammatory agents. J. Invest. Surgery 1998; 11(--):327-339. >>> Retinoic acid; Quinacrine; Dipyridamole; PBS; Ethanol; injury site; rabbit; 2ML1; controls received mp w/vehicle; tissue perfusion (surgical injury site); animals given morphine i.m. for post-operative pain; catheter stabilized in sidewall w/suture; in some studies, catheter tubing was disconnected to halt flow at specific times; immunology.

3599 Kaya, M., Chang, L., Truong, A., Brightman, M.W. Chemical induction of fenestrae in vessels of the blood-brain barrier. Exp. Neurol 1996; 142(--):6-13. >>> Retinoic acid; Phorbol myristate acetate; ETOH; Gibco BRL minimal essential medium; DMSO; Culture medium, serum-free; CSF/CNS (cortex); rat; 2ML1; controls received mp w/ vehicle; functionality of mp verified by residual volume; pumps replaced weekly.

top of page

18. Retinoic Acid

P7250 Liu,T., Bohlken,A., Kuljaca,S., Lee,M., Nguyen,T., Smith,S., Cheung,B., Norris,M.D., Haber,M., Holloway,A.J., Bowtell,D.D.L., Marshall,G.M. The retinoid anticancer signal: mechanisms of target gene regulation. British Journal of Cancer 2005; 93(-3-):310-318. >>> Retinoic acid, 13-cis-; Ethanol; SC; Mice (transgenic); 1007D; 5 weeks; Controls received mp w/ vehicle; dose-response (fig. 1); no stress (see pg. 312-13); cancer (neuroblastoma).

P7232 Karam,S.M., John,R., Alpers,D.H., Ponery,A.S. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23(-3-):433-441. >>> Retinoic acid; uridine, bromodeoxy-; SC; Mice; 1, 3, 6 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; cancer (gastric); multiple pumps per animal (2).

P4739 Kopke,R.D, Jackson,R.L, Li,G, Rasmussen,M.D, Hoffer,M.E, Frenz,D.A, Costello,M, Schultheiss,P, Van De Water,T.R. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function.. PNAS 2001; 98(-10-):5886-5891. >>> Transforming growth factor; insulin-like growth factor I; retinoic acid; brain-derived neurotrophic factor;; PBS; BSA;; Ear (vestibule); Guinea-pig; 2002; 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; peptides; IntraEAR catheter used; GFI group pumps filled with TGF, IGF and Retinoic acid; GFII group pumps filled with TGF, IGF, BDNF and retinoic acid; tissue perfusion (vestibule).

P4026 Rodgers,K.E., Girgis,W., Amand,K.St., Campeau,J.D., diZerega,G.S. Reduction of adhesion formation by intraperitoneal administration of various anti-inflammatory agents. J.Invest.Surgery 1998; 11(--):327-339. >>> Retinoic acid; Quinacrine; Dipyridamole; PBS; Ethanol; injury site; rabbit; 2ML1; 1, 2, 3, 7 days; controls received mp w/vehicle; tissue perfusion (surgical injury site); animals given morphine i.m. for post-operative pain; catheter stabilized in sidewall w/suture; in some studies, catheter tubing was disconnected to halt flow at specific times; immunology.

P3491 Kaya,M., Chang,L., Truong,A., Brightman,M.W. Chemical induction of fenestrae in vessels of the blood-brain barrier. Exp.Neurol. 1996; 142(--):6-13. >>> Retinoic acid; Phorbol myristate acetate; ETOH; Gibco BRL minimal essential medium; DMSO; Culture medium, serum-free; CSF/CNS (cortex); rat; 2ML1; 21, 28 days; controls received mp w/ vehicle; functionality of mp verified by residual volume; pumps replaced weekly.

top of page

19. Riboflavin

9651 Hasegawa, T., Iwanaga, K., Hultquist, D.E., Liao, H., Visovatti, S.H., Pinsky, D.J. Suppression of nitrosative and oxidative stress to reduce cardiac allograft vasculopathy. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-4-):H1007-H1016. >>> Riboflavin; Saline; IP; Mice; 1003D; Controls received mp w/ vehicle; functionality of mp verified by plasma riboflavin levels; dose-response (fig. 1); cardiovascular; immunology; animal info (male, CBA/J, B1OA, 8-12 wks old, cardiac transplantation); antioxidant.

top of page

20. SS-31

16256 Shi, J., Dai, W., Hale, S. L., Brown, D. A., Wang, M., Han, X., Kloner, R. A. Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. Life Sci 2015; 141(--):170-8. >>> SS-31; water; SC; rat; 2006; Controls received mp w/ vehicle, sham operation; animal info (female Sprague–Dawley rats); ischemia (myocardial infarction); cardiovascular; SS-31 aka Bendavia; Dose (3 mg/kg/day);.

15954 Liu, S., Soong, Y., Seshan, S. V., Szeto, H. H. Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis. Am J Physiol Renal Physiol 2014; 306(-9-):F970-80. >>> SS-31; saline; SC; rat; 2004; Controls: sham operated animals; animal info [Male Sprague-Dawley rats (250–300 g)]; ischemia (bilateral renal); peptides; cell-permeable peptide that targets inner mitochondrial membrane; SS-31 aka Bendavia;.

14705 Dai, W.D., Shi, J.R., Gupta, R.C., Sabbah, H.N., Hale, S.L., Kloner, R.A., Dai, W.D. Bendavia, a Mitochondria-targeting Peptide, Improves Postinfarction Cardiac Function, Prevents Adverse Left Ventricular Remodeling, and Restores Mitochondria-related Gene Expression in Rats. Journal of Cardiovascular Pharmacology 2014; 64(--):543-553. >>> SS-31; Water; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-300g); no stress (see pg. 545-546)"Sixty-four rats were randomized to receive Bendavia or water, and no rats died during the next 6-week treatment."; cardiovascular; peptides; myocardial infarction; bp measured using catheter; long-term study;.

13568 Toyama, S., Shimoyama, N., Ishida, Y., Koyasu, T., Szeto, H.H., Shimoyama, M. Characterization of Acute and Chronic Neuropathies Induced by Oxaliplatin in Mice and Differential Effects of a Novel Mitochondria-targeted Antioxidant on the Neuropathies. Anesthesiology 2014; 120(-2-):459-473. >>> SS-31; Saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, BALBC, 9 weeks); behavioral testing (cold hypersensitivity; mechanical allodynia, von Frey hair test); SS-31 is a mitochondria-target antioxidant.

11291 Dai, D.F., Chen, T., Szeto, H., Nieves-Cintron, M., Kutyavin, V., Santana, L.F., Rabinovitch, P.S. Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy. Journal of the American College of Cardiology 2011; 58(-1-):73-82. >>> Angiotensin II; SS-31; SC; Mice; 1004; Animal info (FVBxC57BL/6J F1 hybrid, wt, 12 wks old); SS-31 is a mitochondrial-targeted antioxidant peptide.

top of page

21. Superoxide Dismutase

Q4699 Awonuga,A.O., Fletcher,N.M., Saed,M.G., Nusrat,O., Abusamaan,M.S., Belotte,J., Diamond,M.P., Saed,G.M., Awonuga,A.O. THE IN-VIVO EFFECTS OF SUPEROXIDE DISMUTASE ON THE INCIDENCE AND SEVERITY OF POST-OPERATIVE ADHESION DEVELOPMENT 751. Fertility and Sterility 2014; 102(--):E73-E73. >>> Superoxide dismutase; Saline; IP; Rat; 3 weeks; Controls received mp w/ vehicle; animal info (female, Sprague Dawley);.

Q4451 Ho,Y.H., Lin,Y.T., Wu,C.W.J., Chao,Y.M., Chang,A.Y.W., Chan,J.Y.H., Chan,J.Y.H. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. JOURNAL OF BIOMEDICAL SCIENCE 2015; 22(--):U1-U14. >>> Endotoxin, LPS; NS398; tempol; Saline; DMSO; IP; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10 weeks old, 250-282g); ALZET brain infusion kit 2 used; 1% DMSO used; Multiple pumps per animal (2); post op. care (IM procaine penicillin 1000IU); immunology; used dental cement; NS398 is a COX-2 inhibitor and anti-inflammatory; tempol scavanges ROS;.

Q4343 Cao,W., Li,A.Q., Wang,L.L., Zhou,Z.M., Su,Z.X., Bin,W., Wilcox,C.S., Hou,F.F., Hou,F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. Journal of the American Society of Nephrology 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

Q4181 Wu,K.L.H., Chao,Y.M., Tsay,S.J., Chen,C.H., Chan,S.H.H., Dovinova,I., Chan,J.Y.H., Chan,J.Y.H. Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome. Hypertension 2014; 64(--):815-+. >>> Tempol; coenzyme Q10; CSF, artificial; CSF/CNS (cisterna magna); Rat; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley 8 weeks old, 235-296g); post op. care (1000 IU IM); tissue perfusion (cisterna magna); cardiovascular; diabetes; used PE-10 catheter;.

Q3661 Su,Q., Qin,D.N., Wang,F.X., Ren,J., Li,H.B., Zhang,M., Yang,Q., Miao,Y.W., Yu,X.J., Qi,J., Zhu,Z.M., Zhu,G.Q., Kang,Y.M., Qin,D.N. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 276(--):115-120. >>> Tempol; angiotensin II; CSF, artificial; saline, sterile; CSF/CNS (paraventricular nuclei); Rat; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 250-275g); functionality of mp verified by increase bp; tissue perfusion (paraventricular nucleus); immunology; "The success rate of bilateral microinjection and vein infusion is respectively 65% and 78%." pg 116; bp measured using tail-cuff;.

Q2183 Knight,S.F., Kundu,K., Joseph,G., Dikalov,S., Weiss,D., Murthy,N., Taylor,W.R. Folate Receptor-Targeted Antioxidant Therapy Ameliorates Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology 2012; 23(-5-):793-800. >>> Tempol; Saline; folate; IV (jugular); Mice; 48 hours; Controls received mp w/ vehicle; animal info (male, C57BL/6, 11 wks old); ischemia (renal); 7-day pump used; post op. care (buprenorphine in saline).

Q2125 Ozumi,K., Sudhahar,V., Kim,H.W., Chen,G.F., Kohno,T., Finney,L., Vogt,S., McKinney,R.D., Ushio-Fukai,M., Fukai,T. Role of Copper Transport Protein Antioxidant 1 in Angiotensin II-Induced Hypertension A Key Regulator of Extracellular Superoxide Dismutase. Hypertension 2012; 60(-2-):476-U487. >>> Angiotensin II; Tempol; Saline; SC; Mice; 2002; 7 days; Controls received mp w/ vehicle; animal info (Atox1 -/-, 3 mo old); blood pressure measured via tail cuff.

Q1904 Fujita,M., Ando,K., Kawarazaki,H., Kawarasaki,C., Muraoka,K., Ohtsu,H., Shimizu,H., Fujita,T. Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-Induced Chronic Kidney Disease. Hypertension 2012; 59(-1-):105-U259. >>> Tempol; CSF, artificial; CSF/CNS; IP; Rat; 2002; 4 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 3 wks old); pumps replaced after 2 week; cannula placement verified by ICV injection of Evans Blue dye after euthanization.

Q1866 Loinard,C., Zouggari,Y., Rueda,P., Ramkhelawon,B., Cochain,C., Vilar,J., Recalde,A., Richart,A., Charue,D., Duriez,M., Mori,M., renzana-Seisdedos,F., Levy,B.I., Heymes,C., Silvestre,J.S. C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression. Circulation 2012; 125(-8-):1014-U126. >>> Tempol; Mice; 2002; ; Controls received mp w/ saline; animal info (CHOP-10 deficient, wt, 28 g, 8 wks old); ischemia.

Q1702 Willett,N.J., Kundu,K., Knight,S.F., Dikalov,S., Murthy,N., Taylor,W.R. Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress. ANTIOXIDANTS&REDOX SIGNALING 2011; 15(-5-):1369-1378. >>> Tempol; ebselen; DMSO; saline; SC; IV (jugular); Mice; 2ML1; 1007D; 4 days; Animal info (male, 11-13 wks old, C57BL/6, P47 phox -/-); 50% DMSO used.

Q1156 Kappers,M.H.W., Smedts,F.M.M., Horn,T., van Esch,J.H.M., Sleijfer,S., Leijten,F., Wesseling,S., Strevens,H., Danser,A.H.J., van den Meiracker,A.H. The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System. Hypertension 2011; 58(-2-):295-U351. >>> Tempol; SC; Rat; 2ML2; 8 days; Animal info (male, Wistar, Kyoto, 280-300 g).

P9880 Wu,K.L.H., Hsu,C., Chan,J.Y.H. Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):965-977. >>> Methylisothiourea, S-; PTIO, carboxy-; Coenzyme Q10; tempol; FeTMPyP; furosemide; PJ-34; CSF, artificial; sesame oil; CSF/CNS (spinal cord); Rat; 1003D; 3 days; Controls received mp w/ vehicle; multiple pumps per animal (2); post op. care (procraine penicillin); adult, male, specific pathogen free, 200-250 g.); spinal cord injury; PE-10 catheter used; PTIO is a NO trapping agent; enzyme inhibitor PJ-34 is poly(ADP-ribose) polymerase PARP inhibitor.

P9759 Ge,N.N., Brodie,H.A., Tinling,S.P. Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase. OTOLOGY&NEUROTOLOGY 2008; 29(-8-):1061-1067. >>> Superoxide dismutase; CSF, artificial; CSF/CNS (intrathecal); Gerbil; 1002; 14 days; Controls received IM injections of SOD; half-life (p.1065) 40 hours; animal info (8 wks old, male, Mongolian); dental cement used to hold tubing in place; silastic tubing used; image of surgical placement of pumps fig.2., fig. 4.

P9640 Kang,Y.M., Ma,Y., Zheng,J.P., Elks,C., Sriramula,S., Yang,Z.M., Francis,J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research 2009; 82(-3-):503-512. >>> Angiotensin II; losartan; pyrrolidine dithiocarbamate; tempol; Saline; CSF, artificial; IV (femoral); CSF/CNS; Rat; 4 weeks; Controls received mp w/vehicle; peptides; multiple pumps per animal (2); animal info (adult, male, Sprague-Dawley, 275-300g); bilateral cannula used for multiple drug infusions; bilateral infusion;.

P9252 Qin,Z.Y., Gongora,M.C., Ozumi,K., Itoh,S., Akram,K., Ushio-Fukai,M., Harrison,D.G., Fukai,T. Role of Menkes ATPase in Angiotensin II-Induced Hypertension A Key Modulator for Extracellular Superoxide Dismutase Function. Hypertension 2008; 52(-5-):945-U556. >>> Angiotensin II; norepinephrine; tempol; Saline; SC; Mice; 2002; 14 days; Controls received sham surgery with no mp or empty mp; functionality of mp verified by blood pressure; cardiovascular; peptides; multiple pumps per animal (2); animal info (female, C57BL/6EJ blotchy MNK mut, 8-12 wks old).

P9217 Silva,G.B., Garvin,J.L. Angiotensin II-Dependent Hypertension Increases Na Transport-Related Oxygen Consumption by the Thick Ascending Limb. Hypertension 2008; 52(-6-):1091-1098. >>> Angiotensin II; dye, coomassie blue R250; G86976; tempol; SC; kidney (outer medulla); Rat; 1007D; 4, 7 days; Controls received mp w/ vehicle; tissue perfusion (kidney); functionality of mp verified by residual volume and dye infusion; enzyme inhibitor (PKC a/b); cardiovascular; antihypertensive; peptide; cyanoacrylate adhesive; animal info (Sprague Dawley, 7 wks old, 200-250 g.); catheter fenestrated in one side 10 mm from the tip.

P9146 Zhang,Z.H., Yu,Y., Kang,Y.M., Wei,S.G., Felder,R.B. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H1067-H1074. >>> Aldosterone; RU-28318; Tempol; losartan; CSF, artificial; CSF/CNS; Rat; 2002; 1 week; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, Sprague Dawley, 250-300 g.); silastic tubing used; dental cement used.

P9076 Liu,D.M., Gao,L., Roy,S.K., Cornish,K.G., Zucker,I.H. Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons. Circulation Research 2008; 103(-2-):186-193. >>> Tempol; CSF, artificial; CSF/CNS; Rabbit; 2001; 7 days; Controls received mp w/ vehicle; animal info (New Zealand, White, 3.5-4.3 kg.); 19 gauge cannula used.

P9074 Xue,B.J., Zhao,Y.Z., Johnson,A.K., Hay,M. Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-3-):H1025-H1032. >>> Tempol; estradiol, 17B-; ICI-182780; SC; CSF/CNS; Mice; 1002; 7, 14 days; ALZET brain infusion kit used; peptides; animal info (male, C57BL/6, 12-16 wks old); location of cannula was verified histologically post mortem.

P9053 Kang,Y.M., Ma,Y., Elks,C., Zheng,J.P., Yang,Z.M., Francis,J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappa B. Cardiovascular Research 2008; 79(-4-):671-678. >>> Losartan; SN50; tempol; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 250-275 g.); pumps were primed in 0.9% saline for 24 hours; SN50 is a synthetic protein.

P7696 Wu,D.C., Teismann,P., Tieu,K., Vila,M., Jackson-Lewis,V., Ischiropoulos,H., Przedborski,S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc.Natl.Acad.Sci.U.S.A 2003/5/13; 100(-10-):6145-6150. >>> Tempol; CSF/CNS (striatum); Mice; 7 days; Neurodegenerative (Parkinson's disease).

P7413 Welch,W.J., Mendonca,M., Blau,J., Karber,A., Dennehy,K., Patel,K., Lao,Y.S., Jose,P.A., Wilcox,C.S. Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat. Kidney International 2005; 68(-1-):179-187. >>> Tempol; NaCl; SC; Rat; 2002; ; Controls received mp w/ vehicle; cardiovascular; animal info (male, wistar-kyoto, 210-300 g).

P7123 Kimura,Y., Hirooka,Y., Sagara,Y., Ito,K., Kishi,T., Shimokawa,H., Takeshita,A., Sunagawa,K. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circulation Research 2005; 96(-2-):252-260. >>> Tempol; CSF, artificial; CSF/CNS (cisterna); Rat; 1002; 1 week; Controls received mp w/ vehicle; comparison of CSF/CNS microinjections vs. mp; cardiovascular.

P7099 Benn,S.C., Ay,I., Bastia,E., Chian,R.J., Celia,S.A., Pepinsky,R.B., Fishman,P.S., Brown,RH Jr, Francis,J.W. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. Journal of Neurochemistry 2005; 95(-4-):1118-1131. >>> Toxin, tetanus fragment C; tempol, toxin tetanus fragment C; CSF/CNS; Mice; 2001; 7 days; Stability verified by incubation at 37C for 7 days; brain tissue distribution; post op. care (bupivicaine and betadine in wound); animal info (C57BL/6, male, 25-30 g); dental cement used for cannula adhesion, agent also know as TTC; compounds were also distributed to further brain sites such as the hypothalamus and the thalamus.

P7013 Welch,W.J., Blau,J., Xie,H., Chabrashvili,T., Wilcox,C.S. Angiotensin-induced defects in renal oxygenation: role of oxidative stress. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-1-):H22-H28. >>> Angiotensin II; tempol; Sodium chloride; SC; Rat; 2002; 12-13 days; Controls received mp w/ vehicle; no stress (pg. H23); cardiovascular; antihypertensive; peptides; multiple pumps per animal (2).

P6143 Kawada,N., Imai,E., Karber,A., Welch,W.J., Wilcox,C.S. A mouse model of angiotensin II slow pressor response: Role of oxidati ve stress. Journal of the American Society of Nephrology 2002; 13(-12-):2860-2868. >>> Angiotensin II; tempol; Saline; SC; Mice; 1002; 14 days; Blood pressure taken; dose-response (p. 2862); cardiovascular; peptides.

P6059 Sedeek,M.H., Llinas,M.T., Drummond,H., Fortepiani,L., Abram,S.R., Alexander,B.T., Reckelhoff,J.F., Granger,J.P. Role of reactive oxygen species in endothelin-induced hypertension. Hypertension 2003; 42(-4-):806-810. >>> Endothelin-1; tempol; IV (jugular); Rat; 2002; 9 days; Peptides.

P5848 Gariboldi,M.B., Ravizza,R., Petterino,C., Castagnaro,M., Finocchiaro,G., Monti,E. Study of in vitro and in vivo effects of the piperidine nitroxide Tempol - a potential new therapeutic agent for gliomas. European Journal of Cancer 2003; 39(-6-):829-837. >>> Tempol; Saline, sterile; SC; Mice (nude); 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; comparison of IP injections vs. mp; adverse reaction: (see pg. 835) precipitation in pump; cancer (glioma); antioxidant; tempol (TPL) or (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxy) or superoxide dismutase, mimetic is a stable nitroxide free radical; "375 mg/ml concentration was highest achievable TPL concentration, when this limit was exceeded, TPL precipitation occurred, impairing drug flow from the pump...".

P5654 Welch,W.J., Mendonca,M., Aslam,S., Wilcox,C.S. Roles of oxidative stress and AT(1) receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney. Hypertension 2003; 41(-3-):692-696. >>> Tempol; Rat; 2 weeks; Antihypertensive; also refered as superoxide dismutase, mimetic.

P3263 Karran,E.H., Dodgson,K., Harris,S.J., Markwell,R.E., Harper,G.P. A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents. Inflamm.Res. 1995; 44(--):36-46. >>> Collagenase inhibitor A; Collagenase inhibitor B; Collagenase inhibitor C; tempol; Superoxide dismutase-PEG; Cytochalasin B; Pepstatin; APMSF; TLCK; SBTI; Leupeptin; E-64; Methylamine; SC; Rat; 2001; 2ML1; 7 days; controls received mp w/vehicle; no stress (see pg. 39); immunology; pumps connected with catheter tubing to 14C-collagen-gelled cotton buds.

P3115 Truelove,D., Shuaib,A., Ijaz,S., Richardson,S., Kalra,J. Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults. Neurochem.Res. 1994; 19(-6-):665-671. >>> Tempol; catalase; CSF/CNS; Gerbil; 1007D; 7 days; Controls received mp with saline; agents given separately and together; ischemia (cerebral).

P3114 Truelove,D., Shuaib,A., Ijaz,S., Ishaqzay,R., Kalra,J. Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils. Free Rad.Biol.Med. 1994; 17(-5-):445-450. >>> Superoxide dismutase-PEG; Saline; CSF/CNS; gerbil; 1007D; 6 days; controls received mp with vehicle; ischemia (cerebral).

P2520 Macdonald,R.L., Weir,B.K.A., Runzer,T.D., Grace,M.G.A., Poznansky,M.J. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 1992; 30(-4-):529-539. >>> Catalase; tempol; CSF/CNS (spinal cord, intrathecal); monkey; 2ML1; 7 days; controls received inactivated SOD and BSA; functionality of mp verified by measuring enzyme levels in CSF during infusion and testing agent released from pump in vitro for 7 days; stability verified by measuring activity of enzymes released from pumps in vitro over 7 days; daily CSF sampling performed using a subcutaneous Ommaya reservoir; authors report no cases of catheter blockage or dislodgement.

P2438 Suzuki,S., Kanashiro,M., Hayashi,R., Amemiya,H. Rescue therapy for acute rejection using 15-deoxyspergualin (DSG) in combination with superoxide dismutase (SOD) on cardiac allografts in rats. Transplant.Int. 1992; 5(-Sup.1-):S547-S551. >>> Sodium oxide dismutase, recomb. human (tempol); Saline; IV (vena cava); rat; 2001; 8 days; dose-response (graph p. S550).

P1931 Hattori,T., Ito,M., Suzuki,Y. Changes in intra-renal scavenging enzymes activities of the reactive oxygen species in experimental glomerulo-nephritis and nephrosis in rats. Nippon Jinzo Gakkai Shi 1991; 33(-2-):191-199. >>> Glutathione peroxidase; Catalase; tempol; rat; no duration posted; Japanese with English abstract.

P1741 Mossman,B.T., Marsh,J.P., Sesko,A., Hill,S., Shatos,M.A., Doherty,J., Petruska,J., Adler,K.B., Hemenway,D., Mickey,R., Vacek,P., Kagan,E. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am.Rev.Respir.Dis. 1990; 141(--):1266-1271. >>> Catalase; tempol; PBS; SC; rat; 2ML4; 10, 20 days; functionality of mp verified by serum catalase; PEG-conjugated enzymes; antioxidants; stability of enzymes questioned beyond 20 days.

P1476 Teixeira,A.A., Azevedo,I., Branco,D., Rodrigues-Pereira,E., Osswald,W. Sympathetic denervation caused by long-term noradrenaline infusions; prevention by desipramine and superoxide dismutase. Br.J.Pharmacol. 1989; 97(--):95-102. >>> Desipramine HCl; Norepinephrine; tempol; EDTA; Heparin; Saline; IV (saphenous); dog; 2ML1; 5 days; dose-response; implanted sc above the knee; functionality of mp verified by visual inspection of sectioned pump and by serum levels; tissue perfusion; animal info (m, 9-15 kg); 5000 Units of heparin.

P0153 Gold,G., Manning,M., Heldt,A., Nowlain,R., Pettit,J.R., Grodsky,G.M. Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of protection by exogenous superoxide dismutase. Diabetes 1981; 30(--):634-638. >>> Tempol; Saline; SC; mice; 7 days; comparison of iv injection vs. infusion.

top of page

22. Superoxide Dismutase (Tempol)

16316 Tsai, C. Y., Su, C. H., Chan, J. Y., Chan, S. H. Nitrosative Stress-Induced Disruption of Baroreflex Neural Circuits in a Rat Model of Hepatic Encephalopathy: A DTI Study. Sci Rep 2017; 7(--):40111. >>> FeTMPyP; Tempol; CSF, artificial; CSF/CNS (intracisternal); Rat; 2001; Controls received mp w/ vehicle; animal info (male adult Sprague-Dawley rats 278+/-28 g); FeTMPyP is an active peroxynitrite decomposition catalyst; tempol is an antioxidant; Dose: FeTMPyP (100 pmol/ul/hr); tempol (4 nmol/ul/hr).

15191 Awonuga, A.O., Fletcher, N.M., Saed, M.G., Nusrat, O., Abusamaan, M.S., Belotte, J., Diamond, M.P., Saed, G.M., Awonuga, A.O. THE IN-VIVO EFFECTS OF SUPEROXIDE DISMUTASE ON THE INCIDENCE AND SEVERITY OF POST-OPERATIVE ADHESION DEVELOPMENT751. FERTILITY AND STERILITY 2014; 102(--):E73-E73. >>> Superoxide dismutase; Saline; IP; Rat; Controls received mp w/ vehicle; animal info (female, Sprague Dawley);.

14960 Ho, Y.H., Lin, Y.T., Wu, C.W.J., Chao, Y.M., Chang, A.Y.W., Chan, J.Y.H., Chan, J.Y.H. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. JOURNAL OF BIOMEDICAL SCIENCE 2015; 22(--):U1-U14. >>> Endotoxin, LPS; NS398; tempol; Saline; DMSO; IP; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10 weeks old, 250-282g); ALZET brain infusion kit 2 used; 1% DMSO used; Multiple pumps per animal (2); post op. care (IM procaine penicillin 1000IU); immunology; used dental cement; NS398 is a COX-2 inhibitor and anti-inflammatory; tempol scavanges ROS;.

14861 Cao, W., Li, A.Q., Wang, L.L., Zhou, Z.M., Su, Z.X., Bin, W., Wilcox, C.S., Hou, F.F., Hou, F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

14482 Wu, K.L.H., Chao, Y.M., Tsay, S.J., Chen, C.H., Chan, S.H.H., Dovinova, I., Chan, J.Y.H., Chan, J.Y.H. Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome. Hypertension 2014; 64(--):815-+. >>> Tempol; coenzyme Q10; CSF, artificial; CSF/CNS (cisterna magna); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley 8 weeks old, 235-296g); post op. care (1000 IU IM); tissue perfusion (cisterna magna); cardiovascular; diabetes; used PE-10 catheter;.

13961 Su, Q., Qin, D.N., Wang, F.X., Ren, J., Li, H.B., Zhang, M., Yang, Q., Miao, Y.W., Yu, X.J., Qi, J., Zhu, Z.M., Zhu, G.Q., Kang, Y.M., Qin, D.N. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 276(--):115-120. >>> Tempol; angiotensin II; Cerebrospinal fluid, artificial; saline, sterile; CSF/CNS (paraventricular nuclei); Rat; 1004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 250-275g); functionality of mp verified by increase bp; tissue perfusion (paraventricular nucleus); immunology;"The success rate of bilateral microinjection and vein infusion is respectively 65% and 78%."pg 116; bp measured using tail-cuff;.

top of page

23. Tempol

Q4181 Wu,K.L.H., Chao,Y.M., Tsay,S.J., Chen,C.H., Chan,S.H.H., Dovinova,I., Chan,J.Y.H., Chan,J.Y.H. Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome. Hypertension 2014; 64(--):815-+. >>> Tempol; coenzyme Q10; CSF, artificial; CSF/CNS (cisterna magna); Rat; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley 8 weeks old, 235-296g); post op. care (1000 IU IM); tissue perfusion (cisterna magna); cardiovascular; diabetes; used PE-10 catheter;.

Q3661 Su,Q., Qin,D.N., Wang,F.X., Ren,J., Li,H.B., Zhang,M., Yang,Q., Miao,Y.W., Yu,X.J., Qi,J., Zhu,Z.M., Zhu,G.Q., Kang,Y.M., Qin,D.N. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 276(--):115-120. >>> Tempol; angiotensin II; Cerebrospinal fluid, artificial; saline, sterile; CSF/CNS (paraventricular nuclei); Rat; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 250-275g); functionality of mp verified by increase bp; tissue perfusion (paraventricular nucleus); immunology; "The success rate of bilateral microinjection and vein infusion is respectively 65% and 78%." pg 116; bp measured using tail-cuff;.

Q2183 Knight,S.F., Kundu,K., Joseph,G., Dikalov,S., Weiss,D., Murthy,N., Taylor,W.R. Folate Receptor-Targeted Antioxidant Therapy Ameliorates Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology 2012; 23(-5-):793-800. >>> Tempol; Saline; folate; IV (jugular); Mice; 48 hours; Controls received mp w/ vehicle; animal info (male, C57BL/6, 11 wks old); ischemia (renal); 7-day pump used; post op. care (buprenorphine in saline).

Q2125 Ozumi,K., Sudhahar,V., Kim,H.W., Chen,G.F., Kohno,T., Finney,L., Vogt,S., McKinney,R.D., Ushio-Fukai,M., Fukai,T. Role of Copper Transport Protein Antioxidant 1 in Angiotensin II-Induced Hypertension A Key Regulator of Extracellular Superoxide Dismutase. Hypertension 2012; 60(-2-):476-U487. >>> Angiotensin II; Tempol; Saline; SC; Mice; 2002; 7 days; Controls received mp w/ vehicle; animal info (Atox1 -/-, 3 mo old); blood pressure measured via tail cuff.

Q1904 Fujita,M., Ando,K., Kawarazaki,H., Kawarasaki,C., Muraoka,K., Ohtsu,H., Shimizu,H., Fujita,T. Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-Induced Chronic Kidney Disease. Hypertension 2012; 59(-1-):105-U259. >>> Tempol; CSF, artificial; CSF/CNS; IP; Rat; 2002; 4 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 3 wks old); pumps replaced after 2 week; cannula placement verified by ICV injection of Evans Blue dye after euthanization.

Q1866 Loinard,C., Zouggari,Y., Rueda,P., Ramkhelawon,B., Cochain,C., Vilar,J., Recalde,A., Richart,A., Charue,D., Duriez,M., Mori,M., renzana-Seisdedos,F., Levy,B.I., Heymes,C., Silvestre,J.S. C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression. Circulation 2012; 125(-8-):1014-U126. >>> Tempol; Mice; 2002; ; Controls received mp w/ saline; animal info (CHOP-10 deficient, wt, 28 g, 8 wks old); ischemia.

Q1702 Willett,N.J., Kundu,K., Knight,S.F., Dikalov,S., Murthy,N., Taylor,W.R. Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress. ANTIOXIDANTS&REDOX SIGNALING 2011; 15(-5-):1369-1378. >>> Tempol; ebselen; DMSO; saline; SC; IV (jugular); Mice; 2ML1; 1007D; 4 days; Animal info (male, 11-13 wks old, C57BL/6, P47 phox -/-); 50% DMSO used.

Q1156 Kappers,M.H.W., Smedts,F.M.M., Horn,T., van Esch,J.H.M., Sleijfer,S., Leijten,F., Wesseling,S., Strevens,H., Danser,A.H.J., van den Meiracker,A.H. The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System. Hypertension 2011; 58(-2-):295-U351. >>> Tempol; SC; Rat; 2ML2; 8 days; Animal info (male, Wistar, Kyoto, 280-300 g).

P9880 Wu,K.L.H., Hsu,C., Chan,J.Y.H. Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):965-977. >>> Methylisothiourea, S-; PTIO, carboxy-; Coenzyme Q10; tempol; FeTMPyP; furosemide; PJ-34; CSF, artificial; sesame oil; CSF/CNS (spinal cord); Rat; 1003D; 3 days; Controls received mp w/ vehicle; multiple pumps per animal (2); post op. care (procraine penicillin); adult, male, specific pathogen free, 200-250 g.); spinal cord injury; PE-10 catheter used; PTIO is a NO trapping agent; enzyme inhibitor PJ-34 is poly(ADP-ribose) polymerase PARP inhibitor.

P9640 Kang,Y.M., Ma,Y., Zheng,J.P., Elks,C., Sriramula,S., Yang,Z.M., Francis,J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research 2009; 82(-3-):503-512. >>> Angiotensin II; losartan; pyrrolidine dithiocarbamate; tempol; Saline; CSF, artificial; IV (femoral); CSF/CNS; Rat; 4 weeks; Controls received mp w/vehicle; peptides; multiple pumps per animal (2); animal info (adult, male, Sprague-Dawley, 275-300g); bilateral cannula used for multiple drug infusions; bilateral infusion;.

P9252 Qin,Z.Y., Gongora,M.C., Ozumi,K., Itoh,S., Akram,K., Ushio-Fukai,M., Harrison,D.G., Fukai,T. Role of Menkes ATPase in Angiotensin II-Induced Hypertension A Key Modulator for Extracellular Superoxide Dismutase Function. Hypertension 2008; 52(-5-):945-U556. >>> Angiotensin II; norepinephrine; tempol; Saline; SC; Mice; 2002; 14 days; Controls received sham surgery with no mp or empty mp; functionality of mp verified by blood pressure; cardiovascular; peptides; multiple pumps per animal (2); animal info (female, C57BL/6EJ blotchy MNK mut, 8-12 wks old).

P9217 Silva,G.B., Garvin,J.L. Angiotensin II-Dependent Hypertension Increases Na Transport-Related Oxygen Consumption by the Thick Ascending Limb. Hypertension 2008; 52(-6-):1091-1098. >>> Angiotensin II; dye, coomassie blue R250; G86976; tempol; SC; kidney (outer medulla); Rat; 1007D; 4, 7 days; Controls received mp w/ vehicle; tissue perfusion (kidney); functionality of mp verified by residual volume and dye infusion; enzyme inhibitor (PKC a/b); cardiovascular; antihypertensive; peptide; cyanoacrylate adhesive; animal info (Sprague Dawley, 7 wks old, 200-250 g.); catheter fenestrated in one side 10 mm from the tip.

P9146 Zhang,Z.H., Yu,Y., Kang,Y.M., Wei,S.G., Felder,R.B. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H1067-H1074. >>> Aldosterone; RU-28318; Tempol; losartan; CSF, artificial; CSF/CNS; Rat; 2002; 1 week; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, Sprague Dawley, 250-300 g.); silastic tubing used; dental cement used.

P9076 Liu,D.M., Gao,L., Roy,S.K., Cornish,K.G., Zucker,I.H. Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons. Circulation Research 2008; 103(-2-):186-193. >>> Tempol; CSF, artificial; CSF/CNS; Rabbit; 2001; 7 days; Controls received mp w/ vehicle; animal info (New Zealand, White, 3.5-4.3 kg.); 19 gauge cannula used.

P9074 Xue,B.J., Zhao,Y.Z., Johnson,A.K., Hay,M. Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-3-):H1025-H1032. >>> Tempol; estradiol, 17B-; ICI-182780; SC; CSF/CNS; Mice; 1002; 7, 14 days; ALZET brain infusion kit used; peptides; animal info (male, C57BL/6, 12-16 wks old); location of cannula was verified histologically post mortem.

P9053 Kang,Y.M., Ma,Y., Elks,C., Zheng,J.P., Yang,Z.M., Francis,J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappa B. Cardiovascular Research 2008; 79(-4-):671-678. >>> Losartan; SN50; tempol; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 250-275 g.); pumps were primed in 0.9% saline for 24 hours; SN50 is a synthetic protein.

P7696 Wu,D.C., Teismann,P., Tieu,K., Vila,M., Jackson-Lewis,V., Ischiropoulos,H., Przedborski,S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc.Natl.Acad.Sci.U.S.A 2003/5/13; 100(-10-):6145-6150. >>> Tempol; CSF/CNS (striatum); Mice; 7 days; Neurodegenerative (Parkinson's disease).

P7413 Welch,W.J., Mendonca,M., Blau,J., Karber,A., Dennehy,K., Patel,K., Lao,Y.S., Jose,P.A., Wilcox,C.S. Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat. Kidney International 2005; 68(-1-):179-187. >>> Tempol; NaCl; SC; Rat; 2002; ; Controls received mp w/ vehicle; cardiovascular; animal info (male, wistar-kyoto, 210-300 g).

P7123 Kimura,Y., Hirooka,Y., Sagara,Y., Ito,K., Kishi,T., Shimokawa,H., Takeshita,A., Sunagawa,K. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circulation Research 2005; 96(-2-):252-260. >>> Tempol; CSF, artificial; CSF/CNS (cisterna); Rat; 1002; 1 week; Controls received mp w/ vehicle; comparison of CSF/CNS microinjections vs. mp; cardiovascular.

P7099 Benn,S.C., Ay,I., Bastia,E., Chian,R.J., Celia,S.A., Pepinsky,R.B., Fishman,P.S., Brown,RH Jr, Francis,J.W. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. Journal of Neurochemistry 2005; 95(-4-):1118-1131. >>> Toxin, tetanus fragment C; tempol, toxin tetanus fragment C; CSF/CNS; Mice; 2001; 7 days; Stability verified by incubation at 37C for 7 days; brain tissue distribution; post op. care (bupivicaine and betadine in wound); animal info (C57BL/6, male, 25-30 g); dental cement used for cannula adhesion, agent also know as TTC; compounds were also distributed to further brain sites such as the hypothalamus and the thalamus.

P7013 Welch,W.J., Blau,J., Xie,H., Chabrashvili,T., Wilcox,C.S. Angiotensin-induced defects in renal oxygenation: role of oxidative stress. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-1-):H22-H28. >>> Angiotensin II; tempol; Sodium chloride; SC; Rat; 2002; 12-13 days; Controls received mp w/ vehicle; no stress (pg. H23); cardiovascular; antihypertensive; peptides; multiple pumps per animal (2).

P6143 Kawada,N., Imai,E., Karber,A., Welch,W.J., Wilcox,C.S. A mouse model of angiotensin II slow pressor response: Role of oxidati ve stress. Journal of the American Society of Nephrology 2002; 13(-12-):2860-2868. >>> Angiotensin II; tempol; Saline; SC; Mice; 1002; 14 days; Blood pressure taken; dose-response (p. 2862); cardiovascular; peptides.

P6059 Sedeek,M.H., Llinas,M.T., Drummond,H., Fortepiani,L., Abram,S.R., Alexander,B.T., Reckelhoff,J.F., Granger,J.P. Role of reactive oxygen species in endothelin-induced hypertension. Hypertension 2003; 42(-4-):806-810. >>> Endothelin-1; tempol; IV (jugular); Rat; 2002; 9 days; Peptides.

P5848 Gariboldi,M.B., Ravizza,R., Petterino,C., Castagnaro,M., Finocchiaro,G., Monti,E. Study of in vitro and in vivo effects of the piperidine nitroxide Tempol - a potential new therapeutic agent for gliomas. European Journal of Cancer 2003; 39(-6-):829-837. >>> Tempol; Saline, sterile; SC; Mice (nude); 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; comparison of IP injections vs. mp; adverse reaction: (see pg. 835) precipitation in pump; cancer (glioma); antioxidant; tempol (TPL) or (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxy) or superoxide dismutase, mimetic is a stable nitroxide free radical; "375 mg/ml concentration was highest achievable TPL concentration, when this limit was exceeded, TPL precipitation occurred, impairing drug flow from the pump...".

P5654 Welch,W.J., Mendonca,M., Aslam,S., Wilcox,C.S. Roles of oxidative stress and AT(1) receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney. Hypertension 2003; 41(-3-):692-696. >>> Tempol; Rat; 2 weeks; Antihypertensive; also refered as superoxide dismutase, mimetic.

P3263 Karran,E.H., Dodgson,K., Harris,S.J., Markwell,R.E., Harper,G.P. A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents. Inflamm.Res. 1995; 44(--):36-46. >>> Collagenase inhibitor A; Collagenase inhibitor B; Collagenase inhibitor C; tempol; Superoxide dismutase-PEG; Cytochalasin B; Pepstatin; APMSF; TLCK; SBTI; Leupeptin; E-64; Methylamine; SC; Rat; 2001; 2ML1; 7 days; controls received mp w/vehicle; no stress (see pg. 39); immunology; pumps connected with catheter tubing to 14C-collagen-gelled cotton buds.

P3115 Truelove,D., Shuaib,A., Ijaz,S., Richardson,S., Kalra,J. Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults. Neurochem.Res. 1994; 19(-6-):665-671. >>> Tempol; catalase; CSF/CNS; Gerbil; 1007D; 7 days; Controls received mp with saline; agents given separately and together; ischemia (cerebral).

P2520 Macdonald,R.L., Weir,B.K.A., Runzer,T.D., Grace,M.G.A., Poznansky,M.J. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 1992; 30(-4-):529-539. >>> Catalase; tempol; CSF/CNS (spinal cord, intrathecal); monkey; 2ML1; 7 days; controls received inactivated SOD and BSA; functionality of mp verified by measuring enzyme levels in CSF during infusion and testing agent released from pump in vitro for 7 days; stability verified by measuring activity of enzymes released from pumps in vitro over 7 days; daily CSF sampling performed using a subcutaneous Ommaya reservoir; authors report no cases of catheter blockage or dislodgement.

P2438 Suzuki,S., Kanashiro,M., Hayashi,R., Amemiya,H. Rescue therapy for acute rejection using 15-deoxyspergualin (DSG) in combination with superoxide dismutase (SOD) on cardiac allografts in rats. Transplant.Int. 1992; 5(-Sup.1-):S547-S551. >>> Sodium oxide dismutase, recomb. human (tempol); Saline; IV (vena cava); rat; 2001; 8 days; dose-response (graph p. S550).

P1931 Hattori,T., Ito,M., Suzuki,Y. Changes in intra-renal scavenging enzymes activities of the reactive oxygen species in experimental glomerulo-nephritis and nephrosis in rats. Nippon Jinzo Gakkai Shi 1991; 33(-2-):191-199. >>> Glutathione peroxidase; Catalase; tempol; rat; no duration posted; Japanese with English abstract.

P1741 Mossman,B.T., Marsh,J.P., Sesko,A., Hill,S., Shatos,M.A., Doherty,J., Petruska,J., Adler,K.B., Hemenway,D., Mickey,R., Vacek,P., Kagan,E. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am.Rev.Respir.Dis. 1990; 141(--):1266-1271. >>> Catalase; tempol; PBS; SC; rat; 2ML4; 10, 20 days; functionality of mp verified by serum catalase; PEG-conjugated enzymes; antioxidants; stability of enzymes questioned beyond 20 days.

P1476 Teixeira,A.A., Azevedo,I., Branco,D., Rodrigues-Pereira,E., Osswald,W. Sympathetic denervation caused by long-term noradrenaline infusions; prevention by desipramine and superoxide dismutase. Br.J.Pharmacol. 1989; 97(--):95-102. >>> Desipramine HCl; Norepinephrine; tempol; EDTA; Heparin; Saline; IV (saphenous); dog; 2ML1; 5 days; dose-response; implanted sc above the knee; functionality of mp verified by visual inspection of sectioned pump and by serum levels; tissue perfusion; animal info (m, 9-15 kg); 5000 Units of heparin.

P0153 Gold,G., Manning,M., Heldt,A., Nowlain,R., Pettit,J.R., Grodsky,G.M. Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of protection by exogenous superoxide dismutase. Diabetes 1981; 30(--):634-638. >>> Tempol; Saline; SC; mice; 7 days; comparison of iv injection vs. infusion.

top of page

24. Thioredoxin

15100 Tan, C.Y.R., Weier, Q., Zhang, Y., Cox, A.J., Kelly, D.J., Langham, R.G., Langham, R.G. Thioredoxin-Interacting Protein: A Potential Therapeutic Target for Treatment of Progressive Fibrosis in Diabetic Nephropathy. NEPHRON 2015; 129(--):109-127. >>> Thioredoxin-interacting protein DNAzyme; SC; Rat; 2006; Controls received mp w/ scrambled TXNIP DNAzyme; animal info (female, heterozygous (mRen-2)27, 6 weeks old); pumps replaced every 6 weeks; cardiovascular; diabetes; Thioredoxin-interacting protein aka TXNIP;.

8264 Ueda, S., Nakamura, T., Yamada, A., Teratani, A., Matsui, N., Furukawa, S., Hoshino, Y., Narita, M., Yodoi, J., Nakamura, H. Recombinant human thioredoxin suppresses lipopolysaccharide-induced bronchoalveolar neutrophil infiltration in rat. LIFE SCIENCES 2006; 79(-12-):1170-1177. >>> Thioredoxin, human recomb.; SC; Mice (nude); 2002; Controls received mp w/ PBS; plasma levels taken; cancer (colon, carcinoma); peptides; animal info (female, 6 weeks old, nude); xenograft.

3505 Hawkins, R.L., Mori, M., Inoue, M., Torii, K. Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in Long Evans Cinnamon rats. Pharmacol. Biochem. Behav 1995; 52(-3-):509-515. >>> Thioredoxin; IP; rat; 2002; controls received mp w/saline; pumps replaced after 2 weeks; immunology; peptides; thioredoxin is an endogenous antioxidant protein.

top of page

25. Vitamin B

Q2430 Lildballe,D.L., Mutti,E., Birn,H., Nexo,E. Maximal Load of the Vitamin B12 Transport System: A Study on Mice Treated for Four Weeks with High-Dose Vitamin B12 or Cobinamide. PLoS One 2012; 7(-10-):U386-U392. >>> Cobinamide; vitamin B12; Saline; SC; Mice; 2004; 27 days; Control animals received mp w/ vehicle; animal info (129.S6, 8 wks old, female); "To avoid wound biting between mice, the mice were housed in individual cages for 3 days after surgery."; post op. care (buprenorphine in the water); cobinamide is a vitamin B12 analogue.

P3776 Kiuchi,T., Sei,H., Seno,H., Sano,A., Morita,Y. Effect of vitamin B12 on the sleep-wake rhythm following an 8-hour advance of the light-dark cycle in the rat. Physiol.Behav. 1997; 61(-4-):551-554. >>> Vitamin B12; IP; rat; 2002; 15 days; controls received mp w/saline.

top of page

26. Vitamin E

11861 Hsieh, C.Y., Liu, C.L., Hsu, M.J., Jayakumar, T., Chou, D.S., Wang, Y.H., Hsiao, G., Sheu, J.R. Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLC-gamma-1 and JAK2 phosphorylation. Free Radical Biology and Medicine 2010; 49(-5-):881-893. >>> PMC; tocopherol, alpha; SC; Rat; Controls received mp w/ normal saline; animal info (Wistar, male, 350-400 g); PMC, also known as (2,2,5,7,8-pentamethyl-6-hydroxychromane, is a vitamin E derivative; tocopherol also known as vitamin E.

9876 Irwin, D.C., McCord, J.M., Nozik-Grayck, E., Beckly, G., Foreman, B., Sullivan, T., White, M., Crossno, JT Jr, Bailey, D., Flores, S.C., Majka, S., Klemm, D., van Patot, M.C.T. A potential role for reactive oxygen species and the HIF-1-alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radical Biology and Medicine 2009; 47(-1-):55-61. >>> Ascorbate; glutathione; tocopherol, alpha-; SC; Mice; 1007D; Controls received mp w/saline; animal info (male, C57BL/6J, 25-30g, 10-12 weeks old); compounds were mixed and infused together as an antioxodant cocktail.

3859 Udaka, T., Misao, T., Aoe, M., Date, H., Andou, A., Shimizu, N. The effect of combination therapy with EPC-K1 and low-dose cyclosporine to pulmonary allograft after rat lung transplantation. J. Heart Lung Transplant 1997; 16(--):839-845. >>> Vitamin E; IP; rat; 2001; functionality of mp verified by measuring EPC-K1 plasma levels; immunology; EPC-K1 is a diester of a-tocopherol and ascorbic acid; agent also called D-alpha-tocopherol.

2009 Stein, D.G., Halks-Miller, M., Hoffman, S.W. Intracerebral administration of alpha-tocopherol-containing liposomes facilitates behavioral recovery in rats with bilateral lesions of the frontal cortex. J. Neurotrauma 1991; 8(-4-):281-292. >>> Phosphatidylcholine; vitamin E; Liposomes; CSF/CNS (cortex); rat; 2001; Multiple pumps per animal (2); agent also called D-alpha-tocopherol.

top of page

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying ...

“Continuous release of albuterol subcutaneously with a miniosmotic pump resulted in a sustained high plasma albuterol concentration throughout the entire experimental period.” Sartori et al., J Appl Physiol 2002;93:1875-1880.