References on the Administration of Agents to the Solid Tissue of the Brain Using ALZET^® Osmotic Pumps

Q0720 Aumann,T.D., Egan,K., Lim,J., Boon,W.C., Bye,C.R., Chua,H.K., Baban,N., Parish,C.L., Bobrovskaya,L., Dickson,P., Horne,M.K. Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons. Journal of Neurochemistry 2011; 116(-4-):646-658. >>> Apamin; muscimol; quinpirole; riluzole; FPL64176; nimodipine; picrotoxin; benzimidazolinone; CSF/CNS (midbrain); CSF/CNS (dorsal striatum); Mice; 1002; 2 weeks; Animal info (eight-week-old, C57BL6/J, male); ALZET brain infusion kit 1 used; neurodegenerative (Parkinson's disease).

Q0888 Cheong,E., Kim,C., Choi,B.J., Sun,M., Shin,H.S. Thalamic Ryanodine Receptors Are Involved in Controlling the Tonic Firing of Thalamocortical Neurons and Inflammatory Pain Signal Processing. Journal of Neuroscience 2011; 31(-4-):1213-1218. >>> Caffeine; ryanodine; CSF/CNS (thalamus); Mice; ; Controls received mp w/ vehicle; animal info (F1 hybrid, male); cannula placement verified postmortem via histology.

Q0773 Cuevas,P., Carceller,F., Angulo,J., Gonzalez-Corrochano,R., Cuevas-Bourdier,A., Gimenez-Gallego,G. Antiglioma effects of a new, low molecular mass, inhibitor of fibroblast growth factor. Neuroscience Letters 2011; 491(-1-):1-7. >>> Dobesilate; PBS; CSF/CNS (intratumoral); Rat; 2004; 27 days; Controls received mp w/ vehicle; cancer (glioma); Compound, also known as (2,5-dihydroxyphenyl-sulfonate or 2,5DHPS) is an FGF inhibitor; chemotherapeutic.

Q0854 da Silva,A.Q.G., Fontes,M.A.P., Kanagy,N.L. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. Brain Research 2011; 1368(-;-):231-238. >>> A-779; losartan; ZD7155; PD123319; muscimol); CSF/CNS (paraventricular nucleus); Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 250-300 g); bilateral guide cannula used.

Q0881 Hosp,J.A., Pekanovic,A., Rioult-Pedotti,M.S., Luft,A.R. Dopaminergic Projections from Midbrain to Primary Motor Cortex Mediate Motor Skill Learning. Journal of Neuroscience 2011; 31(-7-):2481-2487. >>> Levodopa; Saline; ascorbic acid; CSF/CNS (primary motor cortex); Rat; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (adult, male, Long-Evans, 8-10 wks old, 250-350 g).

Q0792 Johnson,J.L., Devel,L., Czarny,B., George,S.J., Jackson,C.L., Rogakos,V., Beau,F., Yiotakis,A., Newby,A.C., Dive,V. A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apolipoprotein E-Knockout Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011; 31(-3-):528-U127. >>> Glycine, L-allyl; glycine, D-allyl; CSF/CNS (hypothalamus, dorsomedial-perifornical); Rat; 5 days; Animal info (adult, male, Sprague Dawley, 300-350 g); enzyme inhibitor (glutamic acid decarboxylase); Plastics One cannula used.

Q0865 Lee,S., Ueno,M., Yamashita,T. Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of gamma-aminobutyric acid signaling. Cell Death&Disease 2011; 2(-;-):U102-U109. >>> Muscimol; CSF/CNS (left motor cortex); Mice; 1004; 7 days; Controls received mp w/ saline; animal info (C57BL/6J, 8 wks old); ALZET brain infusion kit 3 used; "No apparent damage to the cortical cells by saline or muscimol infusion in the contralesional cortex. " Supplementary pg 1; Supplementary Figure 1 illustrates the experimental procedures for the muscimol treatment.

Q0878 Ortuzar,N., Argandona,E.G., Bengoetxea,H., Lafuente,J.V. Combination of intracortically administered VEGF and environmental enrichment enhances brain protection in developing rats. Journal of Neural Transmission 2011; 118(-1-):135-144. >>> Vascular endothelial growth factor; CSF/CNS (cortex); Rat; 1007D; 7 days; Controls received mp w/ PBS or no implantation; animal info (Long-Evans, P18); cyanoacrylate adhesive; ALZET brain infusion kit 3 used; "Total operating time was approximately 25 min." pg 137.

Q0716 Pabon,M.M., Bachstetter,A.D., Hudson,C.E., Gemma,C., Bickford,P.C. CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of Neuroinflammation 2011; 8(-;-):U1-U7. >>> CX3CL1; fractaline, heat inactivated; CSF/CNS (striatum); Rat; 2004; 28 days; Controls received mp w/ fractaline; animal info (Fisher 344, 3 mo old, male); neurodegenerative (Parkinson disease, Alzheimer disease).

Q0737 Pineda,E.A., Hensler,J.G., Sankar,R., Shin,D., Burke,T.F., Mazarati,A.M. Plasticity of Presynaptic and Postsynaptic Serotonin 1A Receptors in an Animal Model of Epilepsy-Associated Depression. Neuropsychopharmacology 2011; 36(-6-):1305-1316. >>> Mifepristone; DMSO; CSF/CNS (dorsal raphe); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 50 days old); functionality of mp verified by residual volume; 10% DMSO used.

Q0736 Sanchez,M.G., Estrada-Camarena,E., Belanger,N., Morissette,M., Di Paolo,T. Estradiol modulation of cortical, striatal and raphe nucleus 5-HT(1A) and 5-HT(2A) receptors of female hemiparkinsonian monkeys after long-term ovariectomy. Neuropharmacology 2011; 60(-4-):642-652. >>> MPTP; CSF/CNS (substantia nigra); Monkey (macaque); 1-2 weeks; Animal info (hemiparkinsonian, OVX, female, Macaca fascicularis); neurodegenerative (Parkinson's disease).

Q0779 Sarkis,R., Saade,N., Atweh,S., Jabbur,S., Al-Amin,H. Chronic dizocilpine or apomorphine and development of neuropathy in two rat models I: Behavioral effects and role of nucleus accumbens. Experimental Neurology 2011; 228(-1-):19-29. >>> MK-801; apomorphine HCL hemihydrate; Saline; ascorbic acid; CSF/CNS (nucleus accumbens); Rat; 2002; ; Controls received mp w/ vehicle; animal info (adult, female, Sprague Dawley, 200-300 g); post op. care (dexamethasone injections to prevent brain edema); behavioral testing (mechanical allodynia, Paw withdrawal latency, cold allodynia, hotplate test, spontaneous motor activity); cannula placement verified by picomicrograph of brain section; CCI, chronic constriction injury; SNI, spared nerve injury.

Q0781 Schulte,A., Guenther,H.S., Phillips,H.S., Kemming,D., Martens,T., Kharbanda,S., Soriano,R.H., Modrusan,Z., Zapf,S., Westphal,M., Lamszus,K. A Distinct Subset of Glioma Cell Lines with Stem Cell-like Properties Reflects the Transcriptional Phenotype of Glioblastomas and Overexpresses CXCR4 as Therapeutic Target. Glia 2011; 59(-4-):590-602. >>> AMD3100; CSF/CNS (intratumoral); Mice; 2004; ; Controls received mp w/ PBS; animal info (6-8 wks old, NMRI-nu/nu); ALZET brain infusion kit 2 used; cancer (glioma).

Q0653 Syed,Y.A., Hand,E., Moebius,W., Zhao,C., Hofer,M., Nave,K.A., Kotter,M.R. Inhibition of CNS Remyelination by the Presence of Semaphorin 3A. Journal of Neuroscience 2011; 31(-10-):3719-3728. >>> Sema3A; PBS; CSF/CNS (caudal cerebellar peduncle); Rat; 2002; 10 days; Controls received mp w/ PBS; animal info (female, Sprague Dawley, 180-200 g); peptides; cyanoacrylate adhesive; Plastics One cannula used; pumps implanted after 10-day delay; tissue perfusion (caudal cerebellar peduncle).

Q0778 Voutilainen,M.H., Baeck,S., Peraenen,J., Lindholm,P., Raasmaja,A., Maennistoe,P.T., Saarma,M., Tuominen,R.K. Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease. Experimental Neurology 2011; 228(-1-):99-108. >>> Central dopmaine neurotrophic factor; mesencephalic astrocyte-derived neurotrophic factor; glial-derived neurotrophic factor; PBS; CSF/CNS (striatum); Rat; 2002; 3, 14 days; Controls received mp w/ vehicle; animal info (male, Wistar, 250-280 g); neuroprotection.

Q0828 Wu,S.Y., Wang,T.F., Yu,L., Jen,C.J., Chuang,J.I., Wu,F.S., Wu,C.W., Kuo,Y.M. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. BRAIN BEHAVIOR AND IMMUNITY 2011; 25(-1-):135-146. >>> Brain-derived neurotrophic factor, recomb. human; CSF, artificial; CSF/CNS (striatum); Mice; 1002; 14 days; Controls received sham surgery; animal info (C57BL/6J, 8 wks old, 20-25 g).

Q0783 Zhai,H.Y., Heppner,F.L., Tsirka,S.E. Microglia/Macrophages Promote Glioma Progression. Glia 2011; 59(-3-):472-485. >>> Ganciclovir; macrophage/microglia inhibitory factor; tuftsin; CSF/CNS (intratumoral); Mice; 14, 28 days; Negative controls received mp w/ saline; animal info (12-16 wks old, male, CD11b-HSVTK +/-, 25-30 g, C57BL/6); cancer (glioma); Plastics One guide cannula used; macrophage/microglia inhibitory factor also known as MIF/TKP is a tripeptide; tuftsin also known as threonine-lysine-proline-arginin or TKPR.

Q0397 Aguirre,A., Rubio,M.E., Gallo,V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature 2010; 467(-7313-):323-U101. >>> Ara-C; epidermal growth factor; Saline; CSF/CNS (surface); CSF/CNS; Mice; 5, 6 days; Controls received mp w/vehicle; animal info (Cnp-hEGFR); incorrectly stated model 1007.

Q0863 Broadbent,N.J., Squire,L.R., Clark,R.E. Sustained Dorsal Hippocampal Activity is Not Obligatory for Either the Maintenance or Retrieval of Long-Term Spatial Memory. Hippocampus 2010; 20(-12-):1366-1375. >>> Lidocaine; CSF/CNS (hippocampus); Rat; 2ML2; 2ML1; 7 days; Controls received mp w/ aCSF; animal info (Long-Evans, naive, male, 300-350 g); good methods "Seven days after minipump implantation, rats were anesthetized with isoflurane gas, the tubing attached to the internal cannula sealed" pg 3; multiple pumps per animal (2); post op. care (Baytril antibiotic); multiple Plastics One cannulae used.

Q0108 Chakrabarty,S., Martin,J.H. Postnatal Development of a Segmental Switch Enables Corticospinal Tract Transmission to Spinal Forelimb Motor Circuits. Journal of Neuroscience 2010; 30(-6-):2277-2288. >>> Muscimol; Saline, sterile; CSF/CNS (motor cortex); Cat; 2002; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit used; post op. care (cephalozine, buprenorphine); GABA-A agonist.

Q0148 Chen,J.J., Lue,J.H., Lin,L.H., Huang,C.T., Chiang,R.P.Y., Chen,C.L., Tsai,Y.J. Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury. Pain 2010; 148(--):158-166. >>> Fluorocitrate; CSF/CNS (cuneate nucleus); Rat; 2004; ; Controls received mp w/ vehicle; functionality of mp verified by residual volume; animal info (male, Sprague Dawley, 180-250 g.); 5 day surgical recovery period.

Q0609 Chen,Q.M., Butler,D., Querbes,W., Pandey,R.K., Ge,P., Maier,M.A., Zhang,L.G., Rajeev,K.G., Nechev,L., Kotelianski,V., Manoharan,M., Sah,D.W.Y. Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery. JOURNAL OF CONTROLLED RELEASE 2010; 144(-2-):227-232. >>> RNA, small interfering; cholesterol-conjugate siRNA; PBS; CSF/CNS (corpus callosum); Rat; 2ML1; 7 days; Controls received mp w/ vehicle; gene therapy; animal info (Male Sprague-Dawley); tissue perfusion (parenchyma); Agents are CNPase siRNA, Cholesterol-CNPas siRNA, Cholesterol-Luciferase siRNA.

Q0426 Cho,K.J., Kim,H.J., Park,S.C., Kim,H.W., Kim,G.W. Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death. MOLECULAR AND CELLULAR NEUROSCIENCE 2010; 45(-3-):267-276. >>> Antibody, anti-APE/Ref-1, rabbit; RNA, small interfering; Saline; CSF/CNS (hippocampus); Mice; 1003D; 3 days; Controls received mp w/ vehicle; animal info (3 months old, male, ICR, 35-40 g); siRNA against APE/Ref-1.

Q0113 Ding,D., Kanaly,C.W., Bigner,D.D., Cummings,T.J., Herndon,JE II, Pastan,I., Raghavan,R., Sampson,J.H. Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. Journal of Neuro-oncology 2010; 98(-1-):1-7. >>> MR1-1; Gadolinium-DTPA; Saline; albumin, human serum; CSF/CNS (parenchyma); Rat; 2ML2; 5 days; Toxicology; cancer (glioblastoma); no stress (see pg. 4); animal info (male, Fisher 344, 3 months old); dose-response (Fig.1); skin wounds closed with wound clips; behavioral testing (stepping and placing reflex and incline ramp climbing ability); CED (Convection-enhanced delivery) infusion; "All rats survived the entirety of the study without clinical or histological toxicity attributable to the study drugs." (p. 1); MR1-1 is a recomb. immunotoxin of a mAb-endotoxin frag; Plastics One cannula used; MRI; brain tissue distribution.

Q0338 Gabriele,N., Pontoriero,G.F., Thomas,N., Shethwala,S.K., Pristupa,Z.B., Gabriele,J.P. Knockdown of Mortalin Within the Medial Prefrontal Cortex Impairs Normal Sensorimotor Gating. Synapse 2010; 64(-11-):808-813. >>> Oligodeoxynucleotide; CSF/CNS (medial prefrontal cortex); Rat; 3 weeks; Controls received mp w/ control sense; animal info (naive, male, Sprague-Dawley); antisense (mortalin); guide cannula used; 0.5 ul/hr pump used; behavioral testing (prepulse inhibition, social interaction).

Q0013 Goldshmit,Y., Munro,K., Leong,S.Y., Pebay,A., Turnley,A.M. LPA receptor expression in the central nervous system in health and following injury. Cell and Tissue Research 2010; 341(-1-):23-32. >>> ; CSF/CNS (cortex); Mice; 3 days; Cyanoacrylate adhesive; ALZET brain infusion kit used; cancer; animal info (C57BL/6, 3 months old); post op. care (metacam); no pump used.

Q0119 Harauzov,A., Spolidoro,M., DiCristo,G., De Pasquale,R., Cancedda,L., Pizzorusso,T., Viegi,A., Berardi,N., Maffei,L. Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity. Journal of Neuroscience 2010; 30(-1-):361-371. >>> Picrotoxin; Mercaptopropionic acid, 3-; CSF/CNS (visual cortex); Rat; 1007D; 1 week; 2, 4-6 days; Controls received mp w/ saline; no stress (see pg. 362); animal info (Long-Evans, 85 days, monocular deprivation).

Q0058 Hughes,E.G., Peng,X.Y., Gleichman,A.J., Lai,M.Z., Zhou,L., Tsou,R., Parsons,T.D., Lynch,D.R., Dalmau,J., Balice-Gordon,R.J. Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis. Journal of Neuroscience 2010; 30(-17-):5866-5875. >>> Antibody, NR1; CSF/CNS (hippocampus); Rat; 2002; 2 weeks; Controls received mp w/ control CSF; ALZET brain infusion kit 3 used; animal info (female, Lewis, 7-8 wks old).

Q0542 Jablonska,B., Aguirre,A., Raymond,M., Szabo,G., Kitabatake,Y., Sailor,K.A., Ming,G.L., Song,H.J., Gallo,V. Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination. Nature Neuroscience 2010; 13(-5-):541-U43. >>> Chordin; antibody, anti-chordin; Saline; CSF/CNS (subventricular zone); Mice; 1007D; 5 days; Controls received mp w/ vehicle; animal info (Dcx-BAC-CreERT2 Tg); ALZET brain infusion kit used; incorrectly stated Model 1007 pumps used; incorrectly listed rate of infusion for Model 1007D pumps as 0.25 ul/hr; chordin is a BMP antagonist.

Q0949 Johnson,P.L., Truitt,W., Fitz,S.D., Minick,P.E., Dietrich,A., Sanghani,S., Traeskman-Bendz,L., Goddard,A.W., Brundin,L., Shekhar,A. A key role for orexin in panic anxiety. Nature Medicine 2010; 16(-1-):111-U149. >>> Allylglycine, L-; allylglycine, D-; sodium lactate; CSF/CNS (hypothalamus); IV; Rat; 5 days; 48 hours; Controls received mp w/ isotonic saline; animal info (adult, male, Sprague-Dawley, 300-350 g); enzyme inhibitor (glutamic acid decarboxylase); Plastics One cannula used.

Q0738 Lagraize,S.C., Guo,W., Yang,K., Wei,F., Ren,K., Dubner,R. SPINAL CORD MECHANISMS MEDIATING BEHAVIORAL HYPERALGESIA INDUCED BY NEUROKININ-1 TACHYKININ RECEPTOR ACTIVATION IN THE ROSTRAL VENTROMEDIAL MEDULLA. Neuroscience 2010; 171(-4-):1341-1356. >>> Substance P; PBS; CSF/CNS (rostral ventromedial medulla); Rat; 1003D; 24 hours; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 80-300 g); pain.

Q0502 Lebel,M., Chagniel,L., Bureau,G., Cyr,M. Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat. NEUROBIOLOGY OF DISEASE 2010; 38(-1-):59-67. >>> L-DOPA; CSF/CNS (striatum); Rat; 2004; 2ML1; 2ML4; 21 days; Controls received mp w/ vehicle; pumps replaced every week; cyanoacrylate adhesive; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley).

Q0098 Leblois,A., Wendel,B.J., Perkel,D.J. Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors. Journal of Neuroscience 2010; 30(-16-):5730-5743. >>> Dopamine; SCH23390; Saline; CSF/CNS (area X); Bird (zebra finch); 1002; ; Controls received mp w/ vehicle; good methods (pg 5731); ALZET brain infusion kit used; animal info (adult, male); Y connector used; pump externalized with a backpack; pump placed inside microcentrifuge tube; cannula placement verified by histological examination.

Q0427 Li,W.D., Wu,Y., Min,F.G., Li,Z., Huang,J.Y., Huang,R. A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-beta42 and thiorphan. METABOLIC BRAIN DISEASE 2010; 25(-3-):277-284. >>> Thiorphan; Saline; ascorbic acid; CSF/CNS (basal ganglia); Monkey; 2ML4; 28 days; Controls received mp w/saline; animal info (middle aged, rhesus, male, 16-17 years old); neurodegenerative (Alzheimer's disease).

Q0498 Mazarati,A.M., Pineda,E., Shin,D., Tio,D., Taylor,A.N., Sankar,R. Comorbidity between epilepsy and depression: Role of hippocampal interleukin-1beta. NEUROBIOLOGY OF DISEASE 2010; 37(-2-):461-467. >>> Interleukin-1, receptor antagonist, human, recomb.; Saline, sterile; CSF/CNS (hippocampus); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit 1 used; multiple pumps per animal (2); animal info (male, Wistar, 50 days old); bilateral hippocampal infusion.

Q0357 McCormack,A.L., Mak,S.K., Henderson,J.M., Bumcrot,D., Farrer,M.J., Di Monte,D.A. alpha-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra. PLoS One 2010; 5(-8-):U312-U319. >>> RNA, small interferring; PBS; CSF/CNS (substantia nigra); Monkey (squirrel monkey); 2004; 4 weeks; Controls received mp w/ control siRNA; animal info (feral, adult); alpha synuclein siRNA.

P9890 Mehanna,A., Jakovcevski,I., Acar,A., Xiao,M.F., Loers,G., Rougon,G., Irintchev,A., Schachner,M. Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice. MOLECULAR THERAPY 2010; 18(-1-):34-43. >>> Polysialic acid, mimetic; human natural killer cell-1, mimetic, cyclic; PBS; CSF/CNS (subdural); Mice; 1002; 2 weeks; Control received mp w/ control peptide; peptides; no stress (see pg. 40); animal info (3-4 month old, female, C57BL/6J); spinal cord injury; catheter position confirmed by macrosopic examination; "no adverse effects of the pump implantation, such as infections, paralyses, or aberrant behavior, were observed." pg 40.

Q0507 Mirrione,M.M., Konomos,D.K., Gravanis,I., Dewey,S.L., Aguzzi,A., Heppner,F.L., Tsirka,S.E. Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice. NEUROBIOLOGY OF DISEASE 2010; 39(-1-):85-97. >>> Ganciclovir; Saline; PBS; CSF/CNS (hippocampus); Mice; 1002; 7 days; Controls received mp w/ vehicle; post op. care (buprenorphine HCl); animal info (CD1 1b-, HSVTk +/-, wt, male, female, adult, 20-25 g); Plastics One guide cannula used.

P9909 Morris,M.J., Na,E.S., Johnson,A.K. Mineralocorticoid Receptor Antagonism Prevents Hedonic Deficits Induced by a Chronic Sodium Appetite. Behavioral Neuroscience 2010; 124(-2-):211-224. >>> RU 28318; RU 486; CSF/CNS (intracranial); Rat; 2004; ; Animal info (male, Sprague Dawley, 250-375 g); silastic tubing used; "A better strategy may have been to chronically infuse CAP via osmotic pumps." pg 220; functionality of mp verified by residual volume.

Q0712 Nicoletti,J.N., Lenzer,J., Salerni,E.A., Shah,S.K., Elkady,A., Khalid,S., Quinteros,D., Rotella,F., Betancourth,D., Croll,S.D. Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats. EPILEPSY&BEHAVIOR 2010; 19(-3-):272-277. >>> Vascular endothelial growth factor, 165, recomb. human; vascular endothelial growth factor, inactivated; PBS, sterile; CSF/CNS (hippocampus); Rat; 2002; 2 weeks; Controls received no surgical manipulations or protein infusions; animal info (male Sprague-Dawley, 250-350 g); behavioral testing (Morris water maze, Grid locomotor activity, Light-dark exploration).

Q0794 O'Leary,JC III, Li,Q.Y., Marinec,P., Blair,L.J., Congdon,E.E., Johnson,A.G., Jinwal,U.K., Koren,J.III, Jones,J.R., Kraft,C., Peters,M., Abisambra,J.F., Duff,K.E., Weeber,E.J., Gestwicki,J.E., Dickey,C.A. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular Neurodegeneration 2010; 5(-;-):U1-U11. >>> Methylene blue; Saline; CSF/CNS (hippocampus); Mice; 1004; 1 month; Animal info (7 mo old, rTg4510); cyanoacrylate adhesive; ALZET brain infusion kit 3 used.

Q0132 Sanders,D., Simkiss,D., Braddy,D., Baccus,S., Morton,T., Cannady,R., Weaver,N., Rose,J.E., Levin,E.D. NICOTINIC RECEPTORS IN THE HABENULA: IMPORTANCE FOR MEMORY. Neuroscience 2010; 166(-2-):386-390. >>> Mecamylamine; CSF, artificial; CSF/CNS (lateral habenula nucleus); Rat; 2004; 4 weeks; Controls received mp w/ vehicle; multiple pumps per animal (2); animal info (female, Sprague Dawley, 3 months old, 200-225 g.); two 28-gauge cannulae used; PE tubing used.

Q0095 Schmidt,N.O., Ziu,M., Cargioli,T., Westphal,M., Giese,A., Black,P.M., Carroll,R.S. Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy. Translational Oncology 2010; 3(-1-):43-49. >>> Furegrelate; PBS; CSF/CNS (intratumoral); Mice (nude); 2004; 4 weeks; Controls received mp w/ vehicle; tissue perfusion (tumor); functionality of mp verified by residual volume; stress/adverse reaction: (see pg. 46) "hemosiderin deposits"; cancer (glioma); ALZET brain infusion kit used; animal info (Swiss, 4-6 wks old).

Q0086 Silvestre,D.C., Gil,G.A., Tomasini,N., Bussolino,D.F., Caputto,B.L. Growth of Peripheral and Central Nervous System Tumors Is Supported by Cytoplasmic c-Fos in Humans and Mice. PLoS One 2010; 5(-3-):U234-U243. >>> Oligonucleotide, antisense; oligonucleotide, scrambled; CSF/CNS (caudate putamen); Mice; 2004; 28 days; Controls received mp w/ vehicle; antisense (C-Fos mRNA morpholino); animal info (4 months old, NPcis).

Q0769 Tsiperson,V., Li,X.S., Schwartz,G.J., Raine,C.S., Shafit-Zagardo,B. GAS6 Enhances Repair Following Cuprizone-Induced Demyelination. PLoS One 2010; 5(-12-):U394-U402. >>> Growth arrest-specfic protein 6, recomb. human; PBS; CSF/CNS (corpus callosum); Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (C57Bl6J, male 8 wks old); peptides; cyanoacrylate adhesive; ALZET brain infusion kit 3 used.

Q0198 Zhang,J., Huang,X.Y., Ye,M.L., Luo,C.X., Wu,H.Y., Hu,Y., Zhou,Q.G., Wu,D.L., Zhu,L.J., Zhu,D.Y. Neuronal Nitric Oxide Synthase Alteration Accounts for the Role of 5-HT1A Receptor in Modulating Anxiety-Related Behaviors. Journal of Neuroscience 2010; 30(-7-):2433-2441. >>> 8-OH-DPAT; CSF/CNS (hippocampus); Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6, B6129SF2 wt, nNOS KO, 6-7 weeks old); comparison of CSF/CNS micro injections vs. mp; behavioral testing (novelty suppressed feeding procedure, open-field test, elevated plus maze test).

Q0810 Zhang,Z., Simpkins,J.W. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Research 2010; 1359(-;-):233-246. >>> Okadaic acid; DMSO; CSF, artificial; CSF/CNS (right dorsal hippocampus); Rat; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (adult, Sprague Dawley, ovariectomized); ALZET brain infusion kit used; neurodegenerative (Alzheimer's disease); 1% DMSO used.

P9491 Adachi,M., Autry,A.E., Covington,HE III, Monteggia,L.M. MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome. Journal of Neuroscience 2009; 29(-13-):4218-4227. >>> Hydroxamic acid, suberoylanilide; Cyclodextrin; PBS; CSF/CNS (basolateral amygdala); Mice; 14 days; Controls received mp w/ vehicle; functionality of mp verified by examining the levels of acetylated histone H3 and H4; enzyme inhibitor (histone deacetylase); animal info (male, C57BL/6, 8 wks old); 5% cyclodextrin used; Plastics One bilateral cannula used; suberoylanilide hydroxamic acid also known as SAHA; behavioral testing (rotarod and locomotor activity, open-field test, elevated-plus maze, social interaction test; fear conditioning, pain sensitivity).

P9944 Agrawal,A., Min,D.H., Singh,N., Zhu,H.H., Birjiniuk,A., von Maltzahn,G., Harris,T.J., Xing,D.Y., Woolfenden,S.D., Sharp,P.A., Charest,A., Bhatia,S. Functional Delivery of siRNA in Mice Using Dendriworms. ACS Nano 2009; 3(-9-):2495-2504. >>> RNA, small interfering; epidermal growth factor receptor; dendriworm, dye-labeled; RNA, small interfering, GFP, dendriworm, dye-labeled; CSF/CNS (intratumoral); Mice; 3, 7 days; Tissue perfusion (tumor); cancer (glioblastoma); incorrectly stated pump model 2007; Plastics One cannula used; animial info (Swiss Webster).

Q0562 Bennett,S.P., Boyd,T.D., Norden,M., Padmanabhan,J., Neame,P., Wefes,I., Potter,H. A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease. Journal of Neuroscience Methods 2009; 184(-2-):320-326. >>> Antichymotrypsin, alpha-1; CSF, artificial; CSF/CNS; CSF/CNS (hippocampal parenchyma); Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (PS/APP, PS/APP/ACT, 10 mo old); functionality of mp verified by residual volume; cyanoacrylate adhesive; multiple pumps per animal (2); stability verified ("minimal degradation" after 28 days); custom catheter solution for simultaneous bilateral brain infusions; nitrile cap used to affix custom catheters to the skull; pump plus custom catheter assembly Fig 3e; "entire catheters and pumps we used can be completely removed without terminating the life of the animal" pg 326.

P9840 Blouet,C., Jo,Y.H., Li,X.S., Schwartz,G.J. Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit. Journal of Neuroscience 2009; 29(-26-):8302-8311. >>> Chloroisocaprioc acid; CSF/CNS (mediobasal hypothalamus); Mice; 1002; 2 weeks; Controls received mp w/ aCSF; animal info (male, C57BL/6, 10 wks old); Plastics One Cannula used; guide cannula used; correct cannula placement verified post mortem by India ink injections; pump connected to bifurcation connector.

Q0491 Bodnar,I., Banky,Z., Zelena,D., Halasz,B. Glutamate receptor antagonist infused into the hypothalamic suprachiasmatic nuclei interferes with the diurnal fluctuations in plasma prolactin and corticosterone levels and injected into the mesencephalic dorsal raphe nucleus attenuates the suckling stimulus-induced release of prolactin of the rat. Brain Research Bulletin 2009; 80(-1-2-):9-16. >>> CNQX; Saline; CSF/CNS; CSF/CNS (suprachiasmatic nucleus); Rat; 2001; 3 days; Controls received mp w/ vehicle; animal info (male, primiparous lactating female, Wistar, 300-350 g); guide cannula used.

P9753 Buckmaster,P.S., Ingram,E.A., Wen,X.L. Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy. Journal of Neuroscience 2009; 29(-25-):8259-8269. >>> Rapamycin; DMSO; ethanol; fluorescein; CSF/CNS (dentate gyrus); Rat; 2004; 1-2 months; Controls received mp w/vehicle; functionality of mp verified by fluorescein labeling; long-term study; pumps replaced after 1 month; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley, 34 days old); 50% DMSO used; 15% ethanol used.

Q0807 Cannady,R., Weir,R., Wee,B., Gotschlich,E., Kolia,N., Lau,E., Brotherton,J., Levin,E.D. Nicotinic antagonist effects in the mediodorsal thalamic nucleus: Regional heterogeneity of nicotinic receptor involvement in cognitive function. Biochemical Pharmacology 2009; 78(-7-):788-794. >>> Nicotine; methyllyaconitine; erythroidine, dihydro-beta-; Saline; CSF, artificial; SC; CSF/CNS (mediodorsal thalamic nucleus); Rat; 2004; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (young adult, female, Sprague Dawley); multiple pumps per animal (2); behavioral testing (radial maze); Polypro suturing used to secure the minipumps and tubing; memory.

P9563 Chakrabarty,S., Shulman,B., Martin,J.H. Activity-Dependent Codevelopment of the Corticospinal System and Target Interneurons in the Cervical Spinal Cord. Journal of Neuroscience 2009; 29(-27-):8816-8827. >>> Muscimol; CSF/CNS (motor cortex); Cat (kitten); 2002; 2 weeks; Controls received mp w/saline; ALZET brain infusion kit used; post op. care (cefazolin, buprenorphine); tissue perfusion (motor cortex).

P9557 Chakrabarty,S., Friel,K.M., Martin,J.H. Activity-Dependent Plasticity Improves M1 Motor Representation and Corticospinal Tract Connectivity. Journal of Neurophysiology 2009; 101(-3-):1283-1293. >>> Muscimol; Saline; CSF/CNS (motor cortex); Cat (kitten); 2002; 28 days; Controls received mp w/vehicle; Long-term study; pumps replaced after 2 weeks; ALZET brain infusion kit used; tissue perfusion (motor cortex).

Q0814 Cho,K.J., Lee,B.I., Cheon,S.Y., Kim,H.W., Kim,H.J., Kim,G.W. INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 REDUCES ENDOPLASMIC RETICULUM STRESS AND NUCLEAR HUNTINGTIN FRAGMENTS IN A MOUSE MODEL OF HUNTINGTON DISEASE. Neuroscience 2009; 163(-4-):1128-1134. >>> Antibody, anti-Ask1; CSF/CNs (striatum, intra-); Mice (transgenic); 4 weeks; Controls received mp w/ rabbit IgG or pre-immune Ask1 antibody); animal info (8-12 wks old, R6/2 HD male tg); neurodegenerative (Huntington's disease); behavioral testing (rotarod test); pump infused at a rate of 1 ul/hr.

Q0468 Conner,J.M., Franks,K.M., Titterness,A.K., Russell,K., Merrill,D.A., Christie,B.R., Sejnowski,T.J., Tuszynski,M.H. NGF Is Essential for Hippocampal Plasticity and Learning. Journal of Neuroscience 2009; 29(-35-):10883-10889. >>> Nerve growth factor, recomb. human; CSF, artificial; albumin, rat; CSF/CNS (septum); Rat; 2002; ; Controls received mp w/ vehicle; animal info (adult, female F344, 175-200 g, 3-4 months old); behavioral testing (Morris water maze test).

Q0469 Covington,HE III, Maze,I., LaPlant,Q.C., Vialou,V.F., Ohnishi,Y.N., Berton,O., Fass,D.M., Renthal,W., Rush,AJ III, Wu,E.Y., Ghose,S., Krishnan,V., Russo,S.J., Tamminga,C., Haggarty,S.J., Nestler,E.J. Antidepressant Actions of Histone Deacetylase Inhibitors. Journal of Neuroscience 2009; 29(-37-):11451-11460. >>> MS-275; hydroxamic acid; Cyclodextrin, beta hydroxypropyl; CSF/CNS (nucleus accumbens); Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (9-11 wks old, C57BL/6J, male); enzyme inhibitor (histone deacetylase); multiple pumps per animal (2); Plastics One bilateral cannula used; behavioral testing (social interaction, sucrose preference, forced-swim task, light/dark box); 5% cyclodextrin used; wound clips used; antidepressant.

P9599 Creson,T.K., Hao,Y.L., Engel,S., Shen,Y., Hamidi,A., Zhuo,M., Manji,H.K., Chen,G. The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity. BIPOLAR DISORDERS 2009; 11(-4-):339-350. >>> PD98059; CSF/CNS (anterior cingulate, cortex); Rat; 1002; ; Enzyme inhibitor (ERK); ALZET brain infusion kit 1 used; animal info (male, Sprague Dawley, 250-200g); behavioral testing (open-field, elevated-plus-maze, forced-swim, saccharin preference, amphetamine induced hyperactivity); brain tissue distribution; tissue perfusion (cortex).

P9370 De Bittencourt-Navarrete,R.E., do Nascimento,I.C., Santiago,M.F., Mendez-Otero,R. NMDA receptor blockade alters the intracellular distribution of neuronal nitric oxide synthase in the superficial layers of the rat superior colliculus. Brazilian Journal of Medical and Biological Research 2009; 42(-2-):189-196. >>> MK-801; Saline; CSF/CNS (superior collicus); Rat; 2002; 10-12 days; Controls received mp w/ vehicle; animal info (adult, male Lister); cyanoacrylate adhesive.

Q0585 Elsas,S.M., Hazany,S., Gregory,W.L., Mody,I. Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. Epilepsia 2009; 50(-4-):870-879. >>> Zinc chloride; Saline; CSF/CNS (hippocampal hilus); Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (adult, Wistar, male, 275-325 g); Plastics One cannula used.

Q0603 Gallego,J.M., Ortiz,L., Gutierrez,R., Barcia,J.A. Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 2009; 18(-7-):537-540. >>> Aminobutyric acid, gamma; Saline; CSF/CNS (dorsomedian nuclei of the thalamus); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Wistar); functionality of mp verified by residual volume; multiple pumps per animal (2); bilateral infusion.

P9826 Genud,R., Merenlender,A., Gispan-Herman,I., Maayan,R., Weizman,A., Yadid,G. DHEA Lessens Depressive-Like Behavior via GABA-ergic Modulation of the Mesolimbic System. Neuropsychopharmacology 2009; 34(-3-):577-584. >>> Dehydroepiandrosterone sulfate; PBS; CSF/CNS (ventral tegmental area); CSF/CNS (nucleus accumbens); Rat; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, FSL, 230-260 g.); cannula placement verified by microscopy; brain tissue distribution.

P9942 Gerrikagoitia,I., Martinez-Vullan,L. Guanosine-Induced Synaptogenesis in the Adult Brain In Vivo. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 2009; 292(-12-):1968-1975. >>> Guanosine; PBS; CSF/CNS (left visual cortex); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (3 mo old, Sprague Dawley); fig.1, schematic drawing of brain with ALZET pump and cannula.

Q0549 Giachino,C., Taylor,V. Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulb. European Journal of Neuroscience 2009; 30(-1-):9-24. >>> Ara-C; Saline; CSF/CNS (subventricular zone); Mice; 1007D; 6 days; Controls received mp w/ vehicle; animal info (nestin::CreERT2 Tg, adult, 3 mo old); ALZET brain infusion kit 2 used.

P9863 Gisabella,B., Cunningham,M.G., Bolshakov,V.Y., Benes,F.M. Amygdala-Dependent Regulation of Electrical Properties of Hippocampal Interneurons in a Model of Schizophrenia. Biological Psychiatry 2009; 65(-6-):464-472. >>> Picrotoxin; Saline; CSF/CNS (basolateral amygdala); Rat; 1002; 15 days; Animal info (P30, male, Sprague Dawley); picrotoxin is a noncompetitive GABAA receptor antagonist; infusion rate was reduced by coating 50% of the pump with parafin.

P9673 Haenggi,D., Eicker,S., Beseoglu,K., Rapp,M., Perrin,J., Nawatny,J., Turowski,B., Sommer,C., Steiger,H.J. DOSE-RELATED EFFICACY OF A CONTINUOUS INTRACISTERNAL NIMODIPINE TREATMENT ON CEREBRAL VASOSPASM IN THE RAT DOUBLE SUBARACHNOID HEMORRHAGE MODEL. Neurosurgery 2009; 64(-6-):1155-1159. >>> Nimodipine; CSF/CNS (subarchanoid space); Rat; 2ML1; 2ML2; 5 days; Animal info (male, Wistar, 250-350 g.).

Q0590 Ingram,E.A., Toyoda,I., Wen,X.L., Buckmaster,P.S. Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy. Epilepsia 2009; 50(-1-):56-64. >>> Nicardipine; FK-506; cyclosporin A; DMSO; ethanol; fluorescein; CSF/CNS (dorsal left dentate gyrus); Rat; 2004; 28 days; Controls were treated identically without status epilepticus; animal info (34-52 day old, male, Sprague-Dawley, status epilepticus); functionality of mp verified by fluorescein labeling; ALZET brain infusion kit 2 used; 50% DMSO used; 15% ethanol used.

P9696 Itoh,T., Satou,T., Nishida,S., Tsubaki,M., Hashimoto,S., Ito,H. Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats. MOLECULAR AND CELLULAR BIOCHEMISTRY 2009; 324(-1-2-):191-199. >>> Antibody, anti-amyloid peptide beta; PBS; CSF/CNS (cortex); Rat; 2001; 7 days; Controls received sham operation w/ pump and no cannula; ALZET brain infusion kit 3 used; brain tissue distribution; animal info (male, Wistar, 8-9 wks old, 200-250 g.); traumatic brain injury; Evans blue used to investigate the extent of antibody distribution; behavioral testing (Morris water maze); tissue perfusion (cortex).

Q0613 Kawasaki,M., Ponzio,T.A., Yue,C.M., Fields,R.L., Gainer,H. Neurotransmitter regulation of c-fos and vasopressin gene expression in the rat supraoptic nucleus. Experimental Neurology 2009; 219(-1-):212-222. >>> TTX; CNQX; APV; Saline; CSF/CNS (supraoptic nucleus); Rat; 2001D; 3.5 hours; Controls received mp w/ vehicle; animal info (adult, male, Spraque-Dawley, 250-350 g); functionality of mp verified by measuring Fluorogold in the brain; multiple pumps per animal (2); multiple cannulae (2, 28 gauge) used; pumps not implanted but activated by immersion in 0.9% saline at 37°C.; PE-60 tubing used.

Q0790 Leker,R.R., Toth,Z.E., Shahar,T., Cassiani-Ingoni,R., Szalayova,I., Key,S., Bratincsak,A., Mezey,E. TRANSFORMING GROWTH FACTOR alpha INDUCES ANGIOGENESIS AND NEUROGENESIS FOLLOWING STROKE. Neuroscience 2009; 163(-1-):233-243. >>> Transforming growth factor, alpha; CSF, artificial; CSF/CNS (infarct border); Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (C57B, male, 4-6 wks old).

P9649 Levin,E.D., Perkins,A., Brotherton,T., Qazi,M., Berez,C., Montalvo-Ortiz,J., Davis,K., Williams,P., Christopher,N.C. Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2009; 33(-2-):296-302. >>> Nicotine; methllycaconitine; erithrodine, dihydro-beta; Saline; CSF, artificial; SC; CSF/CNS (medial frontal cortex); Rat; 2004; 2ML4; 4 weeks; Controls received mp w/vehicle; animal info (adult female, SD); multiple pumps per animal (2); bilateral infusion; behavioral testing (radial-Arm-maze).

P9857 Magge,S.N., Malik,S.Z., Royo,N.C., Chen,H.I., Yu,L., Snyder,E.Y., O'Rourke,D.M., Watson,D.J. Role of Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) in Migration of Neural Progenitor Cells Toward Glial Tumors. Journal of Neuroscience Research 2009; 87(-7-):1547-1555. >>> MCP-1, recomb. rat; PBS; BSA; CSF/CNS (corpus callosum); Rat; 1007D; 7 days; Controls received MCP-1 w/o transplant or transplant w/o MCP-1; functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; animal info (adult, Fischer, female, 150-200 g.); brain tissue distribution.

P9816 McAlpine,F.E., Lee,J.K., Harms,A.S., Ruhn,K.A., Blurton-Jones,M., Hong,J., Das,P., Golde,T.E., LaFerla,F.M., Oddo,S., Blesch,A., Tansey,M.G. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. NEUROBIOLOGY OF DISEASE 2009; 34(-1-):163-177. >>> XENP345; PBS, sterile; glycerol; CSF/CNS (hippocampus); Mice; 2004; 28 days; Controls received mp/ vehicle; animal info (young, adult, 4.5 months old, 3xTgAD); Plastics One Cannula used; XENP 345 is a dominant negative TNF inhibitor; neurodegenerative (Alzheimer's Disease); brain tissue distribution.

P9876 Mercado,C., az-Munoz,M., Alamilla,J., Valderrama,K., Morales-Tlalpan,V., guilar-Roblero,R. Ryanodine-Sensitive Intracellular Ca2+ Channels in Rat Suprachiasmatic Nuclei Are Required for Circadian Clock Control of Behavior. Journal of Biological Rhythms 2009; 24(-3-):203-210. >>> Ryanodine; tetrodotoxin; potassium chloride; anisomycin; CSF, artificial; CSF/CNS (suprachiasmatic nucleus); Rat; 14 days; Controls received mp w/ TTX, KCl, anisomycin, or vehicle; animal info (male, Wistar, 250-300 g.); Plastics One cannula used.

P9661 Miyake,J.A., Benadiba,M., Colquhoun,A. Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. Lipids in Health and Disease 2009; 8(-;-):U1-U10. >>> Gamma linolenic acid; CSF, artificial; CSF/CNS (intratumoral); Rat; 2002; 14 days; Controls received mp w/vehicle; cancer (glioma); ALZET brain infusion kit used; animal info (adult, female, Wistar, 250-350).

Q0687 Molina-Luna,K., Pekanovic,A., Roehrich,S., Hertler,B., Schubring-Giese,M., Rioult-Pedotti,M.S., Luft,A.R. Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity. PLoS One 2009; 4(-9-):U127-U136. >>> Levodopa; NaCl; CSF/CNS (primary motor cortex); Rat; ; Controls received mp w/ vehicle; animal info (adult, male, Long-Evans, 332.1 g, ); functionality of mp verified by Nissl staining histology; tissue perfusion (motor cortex).

P9518 Morissette,M., Di Paolo,T. Effect of Estradiol on Striatal Dopamine Activity of Female Hemiparkinsonian Monkeys. Journal of Neuroscience Research 2009; 87(-7-):1634-1644. >>> MPTP; CSF/CNS (substantia nigra); Monkey; 1-2 weeks; Animal info (macaque, 2.8-6.5 kg, 2 years old); MPTP induced hemiparkinsons.

Q0701 Mouret,A., Lepousez,G., Gras,J., Gabellec,M.M., Lledo,P.M. Turnover of Newborn Olfactory Bulb Neurons Optimizes Olfaction. Journal of Neuroscience 2009; 29(-39-):12302-12314. >>> zVAD; Saline; DMSO; CSF/CNS (olfactory bulb); Mice; 1002; 15 days; Controls received mp w/ vehicle; animal info (2 mo old, male, C57BL/6J); peptides; functionality of mp verified by pump weight; ALZET brain infusion kit 3 used; 1.5% DMSO used; Chicago blue dye used to verify cannula placement.

P9766 Mueller,M.C., Osswald,M., Tinnes,S., Haeussler,U., Jacobi,A., Foerster,E., Frotscher,M., Haas,C.A. Exogenous reelin prevents granule cell dispersion in experimental epilepsy. Experimental Neurology 2009; 216(-2-):390-397. >>> Reelin, recomb.; CSF/CNS (hippocampus); Mice; 2002; 2 weeks; Negative controls received mp w/saline; stability verified by western blot analysis (2 wks); brain tissue distribution; ALZET brain infusion kit 3 used; animal info (C57BL/6NCrI, male, 8-10 wks old); reelin is an extracellular matrix protein important for neuronal positioning.

P9764 Nagahara,A.H., Merrill,D.A., Coppola,G., Tsukada,S., Schroeder,B.E., Shaked,G.M., Wang,L., Blesch,A., Kim,A., Conner,J.M., Rockenstein,E., Chao,M.V., Koo,E.H., Geschwind,D., Masliah,E., Chiba,A.A., Tuszynski,M.H. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature Medicine 2009; 15(-3-):331-337. >>> Brain-derived neurotrophic factor, recomb. human; CSF, artificial; CSF/CNS (entorhinal cortex); Rat; 2004; 4 weeks; Controls received mp w/vehicle; animal info (cognitively impaired, Fischer); neurodegenerative (Alzheimer's disease); behavioral testing (morris water maze test); bilateral cannula used; brain tissue distribution.

P9744 Opatz,J., Kuery,P., Schiwy,N., Jaerve,A., Estrada,V., Brazda,N., Bosse,F., Mueller,H.W. SDF-1 stimulates neurite growth on inhibitory CNS myelin. MOLECULAR AND CELLULAR NEUROSCIENCE 2009; 40(-2-):293-300. >>> Stromal Cell-derived factor 1a; PBS; BSA; CSF/CNS (subarchanoid space); Rat; 2001; 1 week; Controls received mp w/vehicle; animal info (female, Wistar, 200-250 g, Spinal cord injury).

Q0383 Querbes,W., Ge,P., Zhang,W.J., Fan,Y.P., Costigan,J., Charisse,K., Maier,M., Nechev,L., Manoharan,M., Kotelianski,V., Sah,D.W.Y. Direct CNS Delivery of siRNA Mediates Robust Silencing in Oligodendrocytes. OLIGONUCLEOTIDES 2009; 19(-1-):23-29. >>> RNA, small interferring; CSF/CNS (sorpus callosum); Rat; 2ML1; 2ML2; 3-7 days; Controls received mp w/PBS; animal info (male, Sprague Dawley); Plastics One cannula used.

Q0493 Restani,L., Cerri,C., Pietrasanta,M., Gianfranceschi,L., Maffei,L., Caleo,M. Functional Masking of Deprived Eye Responses by Callosal Input during Ocular Dominance Plasticity. Neuron 2009; 64(-5-):707-718. >>> Muscimol; CSF/CNS (visual cortex); Rat; 1007D; ; Controls received mp w/ saline; animal info (Long-Evans, naive, p15-p30).

Q0693 Rohe,M., Synowitz,M., Glass,R., Paul,S.M., Nykjaer,A., Willnow,T.E. Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression. Journal of Neuroscience 2009; 29(-49-):15472-15478. >>> Brain-derived neurotrophic factor; CSF, artificial; CSF/CNS (hippocampus); Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (BNDF -/-); ALZET brain infusion kit 2 used; neurodegenerative (Alzheimer's disease, Huntington's disease).

P9618 Rousseau,J., Barth,R.F., Moeschberger,M.L., Elleaume,H. EFFICACY OF INTRACEREBRAL DELIVERY OF CARBOPLATIN IN COMBINATION WITH PHOTON IRRADIATION FOR TREATMENT OF F98 GLIOMA-BEARING RATS. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2009; 73(-2-):530-536. >>> Carboplatin; Dextrose; CSF/CNS (intratumoral); Rat; 2001; 6 days; Controls received mp w/vehicle; no stress (see pg. 532); cancer (glioma); ALZET brain infusion kit 2 used; animal info (male, Fisher, 230-260g); "Surgery for pump implantation was well tolerated." pg. 532; "It is noteworthy that the brainstem was not damaged by direct infusion of 200 ul of carboplatin (0.5 mg/mL) at a flow rate of 1uL/h." pg. 535; tissue perfusion (tumor).

P9478 Schauff,A.K., Kim,E.L., Leppert,J., Nadrowitz,R., Wuestenberg,R., Brockmann,M.A., Giese,A. Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation. Journal of Neuro-oncology 2009; 91(-3-):241-249. >>> Furegrelate; CSF/CNS (intratumoral); Mice (nude); 1002; 14 days; Controls were untreated; enzyme inhibitor (thromboxane synthase TXSA); cancer (glioma); tissue perfusion (tumor); ALZET brain infusion kit 3 used; animal info (NMRI).

P9708 Schmidt,N.O., Koeder,D., Messing,M., Mueller,F.J., Aboody,K.S., Kim,S.U., Black,P.M., Carroll,R.S., Westphal,M., Lamszus,K. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Research 2009; 1268(-;-):24-37. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS (parenchyma); Mice (nude); 2004; ; Controls received mp w/PBS; animal info (6 wks old).

P9656 Snapyan,M., Lemasson,M., Brill,M.S., Blais,M., Massouh,M., Ninkovic,J., Gravel,C., Berthod,F., Goetz,M., Barker,P.A., Parent,A., Saghatelyan,A. Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling. Journal of Neuroscience 2009; 29(-13-):4172-4188. >>> Brain-derived neurotrophic factor; immunoglobulin-G-Fe; RNA, small interfering; TrkB-Fr; NaCI; IA (carotid); CSF/CNS (rostral migratory, system); Mice; 1007D; 7 days; Controls received mp w/control siRNA; animal info (2-3 mo old C57BL/J6); brain tissue distribution; ALZET mouse jugular catheter used; heparin added to BDNF.

Q0707 Tange,Y., Miyazaki,M., Iwata,J., Aiko,Y., Sakamoto,S., Mori,K. Novel Antitumor Effect of Carboplatin Delivered by Intracerebral Microinfusion in a Rat Malignant Glioma Model. NEUROLOGIA MEDICO-CHIRURGICA 2009; 49(-12-):572-579. >>> Carboplatin; Glucose, D-; Evans blue; CSF/CNS (intratumoral); Rat; 2001; 3, 7 days; Animal info (male, F344/N Slc, Fischer 220-260 g); brain tissue distribution; ALZET brain infusion kit used; stability verified (4 weeks) pg 573; cancer (glioma); MRI; brain tissue distribution; "... continuous intracerebral microinfusion using the osmotic mini-pump can provide broader distribution of agents than growth of the brain tumor."; "intracerebral microinfusion can attain clinically favorable drug distribution from a single infusion point." pg 576.

P9497 Tange,Y., Kondo,A., Egorin,M.J., Mania-Farnell,B., Daneriallis,G.M., Nakazaki,H., Sredni,S.T., Rajaram,V., Goldman,S., Soares,M.B., Tomita,T. Interstitial continuous infusion therapy in a malignant glioma model in rats. Childs Nervous System 2009; 25(-6-):655-662. >>> Carboplatin; oxaliplatin; Dextrose; IP; CSF/CNS (striatum); Rat; 2001; 5, 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, Fischer 344, 180-220 g.); "By taking advantage of continuous infusion as an administration protocol, CED has the potential to be a powerful modality for brain tumor treatment, as prolonged infusion could increase the amount of time a tumor is exposed to a drug." (pg. 656); "The method uses low-volume... continuous infusion and is not expected to increase intracranial pressure." (pg. 656).

P9086 Thomale,U., Tyler,B., Renard,V., Dorfman,B., Guarnieri,M., Haberl,H., Jallo,G. Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study. Childs Nervous System 2009; 25(-1-):21-28. >>> Carboplatin; Dextrose; CSF/CNS (parenchyma); Rat; 2001; 7 days; Controls received mp w/ vehicle; multiple pumps per animal (2, 3); animal info (male, Fisher); polyethylene tubing (PE) used; x-ray of skull showing cannulae position; pg. 22 illustration of pump and implanted cannulae.

P9808 Thompson,C.K., Brenowitz,E.A. Neurogenesis in an Adult Avian Song Nucleus Is Reduced by Decreasing Caspase-Mediated Apoptosis. Journal of Neuroscience 2009; 29(-14-):4586-4591. >>> Z-VAD-FMK; Z-DEVD-FMK; Z-LEHD-FMK; DMSO; CSF/CNS (telencephalon); Bird (sparrow); 1002; ; Negative controls received mp w/ Z-FA-FMK; enzyme inhibitor (caspase); animal info (10 months old, male, Gambels white crowned); 1% DMSO used; pumps externalized, used "custom-made backpacks", pg 4587; pumps replaced after 11 days; brain tissue distribution.

P9827 Uebele,V.N., Nuss,C.E., Santarelli,V.R., Garson,S.L., Barrow,J.C., Stauffer,S.R., Koblan,K.S., Renger,J.J., Aton,S., Seibt,J., Dumoulin,M., Jha,S.K., Coleman,T., Frank,M.G. T-type calcium channels regulate cortical plasticity in-vivo NR-D-08-7049. NeuroReport 2009; 20(-3-):257-262. >>> TTA-I1; DMSO; CSF, artificial; CSF/CNS (visual cotex); Cat; 2ML2; ; Controls received mp w/ vehicle; ALZET brain infusion kit used; post op. care (antibiotics, analgesics); animal info (36 days); 50% DMSO used; TTA-I1 is a T-typed calcium channel antagonist.

P9792 Uekita,T., Okaichi,H. Pretraining Does Not Ameliorate Spatial Learning Deficits Induced by Intrahippocampal Infusion of AP5. Behavioral Neuroscience 2009; 123(-3-):520-526. >>> AP5; CSF, artificial; CSF/CNS (hippocampus); Rat; 1002; 14 days; Controls received mp w/ vehicle; multiple pumps per animal (2); animal info (male, albino, Wistar, 2 months old); Plastics One cannula used; silicon rubber used.

P9639 van Groen,T., Kadish,I., Wiesehan,K., Funke,S.A., Willbold,D. In vitro and in vivo Staining Characteristics of Small, Fluorescent, A-beta-42-Binding D-Enantiomeric Peptides in Transgenic AD Mouse Models. ChemMedChem 2009; 4(-2-):276-282. >>> FITC-D1; FITC-D3; CSF/CNS (hippocampus); Mice (transgenic); 2004; 4 weeks; Controls received mp w/saline; ALZET brain infusion kit 3 used; peptides; animal info (8 mo old, AP/PS-delta; neurdegenerative (Alzheimer's disease); D1 and D3 are D-amino acid peptides developed specifically to bind to amyloid -beta (1-42); brain tissue distribution.

Q0615 Wang,Y., Zaveri,H.P., Lee,T.S.W., Eid,T. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats A video-intracranial electroencephalographic study. Experimental Neurology 2009; 220(-2-):293-302. >>> Methionine sulfoximine; NaCl; CSF/CNS (hippocampus); Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (Male, Sprague Dawley, 200-250 g); cyanoacrylate adhesive; Plastics One cannula used; "the model of continuous infusion of MSO into the hippocampus in rats reliably and efficiently results in clusters of recurrent, mainly partial seizures that progress over time." pg 301.

P9516 Wissman,A.M., Brenowitz,E.A. The Role of Neurotrophins in the Seasonal-Like Growth of the Avian Song Control System. Journal of Neuroscience 2009; 29(-20-):6461-6471. >>> TrkB-Fc; TrkC-Fc; brain-derived neurotrophic factor; nerve growth factor; PBS; CSF/CNS (robust nucleus of the arcopallium); Bird; 1002; ; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; animal info (sparrow, adult, male, Gambel's white crowned).

Q0488 Yan,Y.P., Lang,B.T., Vemuganti,R., Dempsey,R.J. Galectin-3 mediates post-ischemic tissue remodeling. Brain Research 2009; 1288(-;-):116-124. >>> Antibody, anti Gal-3, normal, mouse; CSF, artificial; CSF/CNS (ipsilateral striatum); Rat; 1007D; 7 days; Controls received mp w/vehicle and sham surgery; animal info (adult, male, SHR, 270-320 g, MCAO); ischemia (cerebral); artificial CSF recipe, pg 122.

Q0760 Yan,Y.P., Lang,B.T., Vemuganti,R., Dempsey,R.J. Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia. NEUROCHEMISTRY INTERNATIONAL 2009; 55(-8-):826-832. >>> Antibody, anti-OPN, mouse; Antibody, normal, mouse; CSF, artificial; CSF/CNS (striatum); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (adult, male, SHR, focal ischemia, MCAO, 270-320 g); aCSF recipe.

P9833 Yoshida,M., Satoh,T., Nakamura,K.C., Kaneko,T., Hata,Y. Cortical activity regulates corticothalamic synapses in dorsal lateral geniculate nucleus of rats. NEUROSCIENCE RESEARCH 2009; 64(-1-):118-127. >>> Muscimol; Ringer's solution; CSF/CNS (visual cortex); Rat; 1007D; 1002; 2004; 2, 7, 15, 18 days; Controls received mp w/ vehicle; animal info (Long Evans, P21-P49, adult); brain tissue distribution; tissue perfusion (visual cortex).

P9338 Bell,H., Chenoweth,B., Wilson,D.A. Neurobehavioral consequences of cortical adaptation disruption during ontogeny. Neuroscience Letters 2008; 445(-1-):47-52. >>> CPPG; CSF/CNS (forebrain); Rat; 14 days; Controls received mp w/ artificial CSF; animal info (male, Long-Evans); CPPG also known as (RS)-a-cyclopropyl-4-phosphono-phenylglycine; mGlur group III antagonist; behavioral testing (rearing, walking, grooming self, scratching, digging, smelling the odor jar, quiet time).

P9392 Bosch,O.J., Neumann,I.D. Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-44-):17139-17144. >>> Vasopressin, arginine; oxytocin; oligonucleotide, antisense; oligonucleotide, missense; Ringer's solution; CSF/CNS; CSF/CNS (medial preoptic area); Rat (pregnant); 1007D; 5-7 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; antisense (AVP-R); peptides; multiple pumps per animal (2); post op. care (Enrofloxacin, Baytril); animal info (female, Wistar, HAB, LAB, 14 wks old); behavioral testing (maternal care, pup retrieval test, elevated plus maze); cannula placement and infusion sites verified with blue ink.

P9732 Chen,Z.L., Yu,H.X., Yu,W.M., Pawlak,R., Strickland,S. Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. Journal of Cell Biology 2008; 183(-7-):1299-1313. >>> Laminin-1, mouse purified; Immunoglobulin G, rabbit; Laminin-1, plasmin digested; Antibody, anti-KA1; CSF/CNS (hippocampus); Mice; 1007D; ; Controls received mp w/vehicle, or PBS; peptides; animal info (adult, male, Lam-gamma-1KO); brain tissue distribution.

P9380 Cheong,E.J., Lee,S.C., Choi,B.J., Sun,M.J., Lee,C.J., Shin,H.S. Tuning Thalamic Firing Modes via Simultaneous Modulation of T- and L-Type Ca2+ Channels Controls Pain Sensory Gating in the Thalamus. Journal of Neuroscience 2008; 28(-49-):13331-13340. >>> Phorbol 12, 13-didecanoate; chelerythrine; apamin; iberiotoxin; CSF/CNS (thalamus); Mice; ; Controls received mp w/ vehicle; animal info (male, C57BL/6, 129S4/SvJac, wt, PLCB4 -/-); cannula position confirmed by post mortem histology; behavioral testing (visceral pain test).

P9402 de Chevigny,A., Cooper,O., Vinuela,A., Reske-Nielsen,C., Lagace,D.C., Eisch,A.J., Isacson,O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells 2008; 26(-9-):2349-2360. >>> Transforming growth factor-a; noggin; PBS; CSF/CNS (striatum); Rat; 1002; 2004; 14, 28, 41 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; brain tissue distribution; peptides; animal info (female, Sprague Dawley, 250-300 g.); behavioral testing (rotation behavior); noggin is a bone morphogenetic protein antagonist; neurodegenerative (Parkinson's Disease).

P9320 De Toni,A., Zbinden,M., Epstein,J.A., Altaba,A.R.I., Prochiantz,A., Caille,I. Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP. Neural Development 2008; 3(-;-):U2-U13. >>> Epidermal growth factor; fibroblast growth factor, basic; RNA, small interfering; Saline, physiological; CSF/CNS; CSF/CNS (dentate gyrus); Rat; 1003D; 3 days; Controls received mp w/ control siRNA; cancer (glioblastoma); peptides; animal info (Swiss, HOP -/-, wt, adult); HOP or control siRNA was coupled to the cell permeant peptide, penetratin.

P9156 Du,Y.L., Li,X.P., Yang,D.H., Zhang,X.J., Chen,S., Huang,K.X., Le,W.D. Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. EXPERIMENTAL BIOLOGY AND MEDICINE 2008; 233(-7-):881-890. >>> Glial-derived neurotrophic factor, recomb.; CSF, artificial; CSF/CNS (striatum); Mice; 1002; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, C57BL/6, 8 wks old); neurodegenerative (Parkinson's disease).

P9315 Gleason,D., Fallon,J.H., Guerra,M., Liu,J.C., Bryant,P.J. Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury. Neuroscience 2008; 156(-1-):81-88. >>> Transforming growth factor-a; PBS; CSF/CNS (caudate putamen); Rat; 1, 3, 5, 7, 28 days; Peptides, animal info (male, 10 wks old); neurodegenerative (Parkinson's Disease); neural stem cell research.

P9330 Hobbs,C.E., Murphy,M.P., Smith,R.A.J., Oorschot,D.E. Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. PEDIATRICS INTERNATIONAL 2008; 50(-4-):481-488. >>> Mitoquinone; NaCl; ethanol; CSF/CNS (striatum); Rat (pregnant); 1003D; 3 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; post op. care (naloxone); animal info (albino, Sprague Dawley); 10% ethanol used; pumps were primed in 37 degrees Celsius Saline.

P9875 Johnson,P.L., Lowry,C.A., Truitt,W., Shekhar,A. Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic. JOURNAL OF PSYCHOPHARMACOLOGY 2008; 22(-6-):642-652. >>> Allylglycine, d-; allylglycine, l-; CSF/CNS (dorsal medial hypothalamus); Rat; 1002; ; Animal info (male, Sprague Dawley, 300-350 g.); Plastics One cannula used; cannula placement verified by binocular microscope; brain tissue distribution.

P9282 Johnson,P.L., Truitt,W.A., Fitz,S.D., Lowry,C.A., Shekhar,A. Neural pathways underlying lactate-induced panic. Neuropsychopharmacology 2008; 33(-9-):2093-2107. >>> Allylglycine, L-; allylglycine, D-; CSF/CNS (dorsomedial hypothalamus); Rat; 2002; 5 days; Controls received mp w/ D-AG; stress/adverse reaction : (see pg. 2097) "some tissue damage at the site of implantation was noted to to the 26-gauge cannula."; enzyme inhibitor (glutamic acid decarboxylase); animal info (male, Sprague Dawley, 300-350 g.); behavioral testing (social interaction test).

P9062 Kaeaeriaeinen,T.M., Garcia-Horsman,J.A., Piltonen,M., Huotari,M., Maennistoe,P.T. Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral Nigral lesions. BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 2008; 102(-3-):300-307. >>> L-DOPA; NaCl, isotonic; ascorbic acid; CSF/CNS (striatum); Rat; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig.2, pg. 302); animal info (male, Wistar, 190-230 g.); pumps incubated at 37 degree Celsius overnight in isotonic saline; behavioral (rotational behavioral); neurodegenerative (Parkinson's Disease).

Q0538 Kaneko,M., Hanover,J.L., England,P.M., Stryker,M.P. TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nature Neuroscience 2008; 11(-4-):497-504. >>> 1NM-PP1; antibody, anti-TrkB; K252a; DMSO; Tween 20; saline; PBS; CSF, artificial; SC; CSF/CNS (cortex); Mice; 6 days; Controls received mp w/ vehicle; animal info (TrkBF616A, wt); enzyme inhibitor (TrkB kinase); 4% DMSO used; 2% Tween 20 used.

P9768 Kang,G.S., Di Wang,X., Mohler,M.L., Kirichenko,O.V., Patil,R., Orr,W.E., Miller,D.D., Geisert,E.E. Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma. Anti-cancer Drugs 2008; 19(-9-):859-870. >>> EDL-155; HBSS; CSF/CNS (intratumoral); Rat; 2001; 7 days; Tissue perfusion (tumor); comparison of IP injections vs. mp; cancer (glioma); animal info (male, Sprague Dawley, 250-350 g); EDL-155 also known as 1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol.

P9529 Kim,M.L., Zhang,B. Effects of TACE inhibition on Amyloid-beta production and APP processing in vitro and in vivo. J Neurosci 2008; 28(-46-):12052-12061. >>> BMS-561392; Citric acid; CSF/CNS (hippocampus); Mice (transgenic); 2004; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (TACE); animal info (6-8 months, wt); "direct infusion was necessary since BMS-561392 does not penetrate the blood brain barrier"; neurodegenerative (Alzheimer's Disease).

P9667 Krum,J.M., Mani,N., Rosenstein,J.M. Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Experimental Neurology 2008; 212(-1-):108-117. >>> Antibody, goat, antimouse, flt-1, neutralising; antibody, goat, antimouse, flk-1, neutralizing; immunoglobulin G, goat, normal; CSF, artificial; CSF/CNS (striatum); Rat; 2001; 3, 7 days; Controls received mp w/ goat IgG; animal info (young adult, Wistar); tissue perfusion (striatum).

P9309 Lane,E.L., Soulet,D., Vercammen,L., Cenci,M.A., Brundin,P. Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease. NEUROBIOLOGY OF DISEASE 2008; 32(-2-):220-228. >>> Interleukin-2; Saline; CSF/CNS (striatum); Rat; 2002; 12 days; Controls received mp w/ vehicle; animal info (female, Sprague Dawley); neurodegenerative (Parkinson's Disease); behavioral testing (rotational behavior and locomotor; axial, limb, and orolingual movements).

P9665 Lewis,J., Melrose,H., Bumcrot,D., Hope,A., Zehr,C., Lincoln,S., Braithwaite,A., He,Z., Ogholikhan,S., Hinkle,K., Kent,C., Toudjarska,I., Charisse,K., Braich,R., Pandey,R.K., Heckman,M., Maraganore,D.M., Crook,J., Farrer,M.J. In vivo silencing of alpha-synuclein using naked siRNA. Molecular Neurodegeneration 2008; 3(-;-):U1-U10. >>> RNA; small interfering; Luciferase; CSF/CNS (hippocampus); Mice; 1002; 15 days; Controls received mp w/PBS; ALZET brain infusion kit 3 used; cyanoacrylate adhesive; animal info (2 mo old, C57 BL/6 female).

P9132 Liu,S., Xu,G.Y., Johnson,K.M., Echetebu,C., Ye,Z.M., Hulsebosch,C.E., McAdoo,D.J. Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: Endogenous neuroprotection. Brain Research 2008; 1231(-;-):63-74. >>> Interleukin-1, beta-, recomb.; interleukin-1, receptor antagonist; CSF, artificial; CSF/CNS (subarachnoid space); Rat; 1003D; 3 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250 g.); spinal cord injury.

P9064 Liu,X.M., Wang,Y.W., Li,D., Ju,X.L. Transplantation of rat neural stem cells reduces stereotypic behaviors in rats after intrastriatal microinfusion of Tourette syndrome sera. Behavioural Brain Research 2008; 186(-1-):84-90. >>> Serum, human; PBS; CSF/CNS (striatum); Rat; 72 hours; Controls received mp with control serum; animal info (male, female, Wistar, 7 wks old, 260-275 g.); pumps filled with PBS, PE tube filled with 50 ul Tourette syndrome sera; pumps implanted following 1 week recovery period from guide cannula implantation; rats were allowed 1 week recovery period prior to pump implantation.

P9680 Martens,T., Laabs,Y., Guenther,H.S., Kemming,D., Zhu,Z.P., Witte,L., Hagel,C., Westphal,M., Lamszus,K. Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2. Clinical Cancer Research 2008; 14(-17-):5447-5458. >>> Cetuximab; CSF/CNS (intratumoral); Mice (nude); 2004; ; Controls received mp w/ vehicle; tissue perfusion (tumor); cancer (glioblastoma); ALZET brain infusion kit 2 used; animal info (NMRI- nu/nu, 6-8 wks old); cetuximab is a monoclonal antibody against EGFR.

P9433 Nephew,B.C., Bridges,R.S. Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats. PHYSIOLOGY&BEHAVIOR 2008; 95(-1-2-):182-186. >>> Vasopressin, d(CH2)5Tyr(Me) Arginine; Saline; CSF/CNS; CSF/CNS (medial amygdala); Rat (pregnant); 2002; 4-6 days; Controls received mp w/ vehicle; dose-response (fig 3); animal info (female, Sprague Dawley, GD18); V1a receptor antagonist; behavioral testing (maternal behavior, social recognition test, maternal memory test); cannula placement confirmed.

P9139 Nicoletti,J.N., Shah,S.K., McCloskey,D.P., Goodman,J.H., Elkady,A., Atassi,H., Hylton,D., Rudge,J.S., Scharfman,H.E., Croll,S.D. Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience 2008; 151(-1-):232-241. >>> Vascular endothelial growth factor, recomb. human; BowAng1; Flt-Fc; CSF/CNS (dorsal hippocampus); Rat; 5 days; Controls received mp w/ PBS; animal info (male, Sprague Dawley, adult, 250-350 g.); cannula, polyvinyl catheter from Plastics One used; BowAng1 is a fusion of four molecules of angiopoietin-1 with two molecules of hFC; Flt-Fc is an immunoadhesin.

P8879 Robinson,L., Killop-Smith,S., Ross,N.L., Pertwee,R.G., Hampson,R.E., Platt,B., Riedel,G. Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats. Psychopharmacology 2008; 198(-4-):551-563. >>> SR141716A; Ethanol; Tween 80; SC; CSF/CNS (hippocampus); Rat; 2002; ; Controls received mp w/ tween 80; animal info (male, Lister Hooded, 250-300g.); SR141716A is a CB1 receptor antagonist; cannulae position verified post mortem; bilateral infusion cannula; memory; learning.

P9441 Sakai,A., Asada,M., Seno,N., Suzuki,H. Involvement of neural cell adhesion molecule signaling in glial cell line-derived neurotrophic factor-induced analgesia in a rat model of neuropathic pain. Pain 2008; 137(-2-):378-388. >>> Oligodeoxynucleotide, phosphorothioate antisense; glial-derived neurotrophic factor, recomb. human; neural cell adhesion molecule, mimetic peptide C3d; oligodeoxynucleotide, phosphorothioate missense; CSF/CNS (subarachnoid space); Rat; 4, 6, 7, 9 days; Controls received mp w/ saline; antisense (NCAM); peptides; multiple pumps per animal (2); animal info (male, Sprague Dawley, 5 wks old, 140-160 g., sciatic nerve injury); behavioral testing (mechanical allodynia, thermal hypersensitivity, paw withdrawal, plantar test).

P9247 Salimi,I., Friel,K.M., Martin,J.H. Pyramidal tract stimulation restores normal corticospinal tract connections and visuomotor skill after early postnatal motor cortex activity blockade. Journal of Neuroscience 2008; 28(-29-):7426-7434. >>> Muscimol; Saline, sterile; CSF/CNS (motor cortex); Cat (kitten); 2002; 2 weeks; Controls received mp w/ vehicle or no treatment; post op. care (Cefazolin, Buprenorphine); animal info (5 weeks old); behavioral testing (horizontal ladder task); cerebral palsy.

P9242 Shabat-Simon,M., Levy,D., Amir,A., Rehavi,M., Zangen,A. Dissociation between rewarding and psychomotor effects of opiates: Differential roles for glutamate receptors within anterior and posterior portions of the ventral tegmental area. Journal of Neuroscience 2008; 28(-34-):8406-8416. >>> CNQX; CSF, artificial; CSF/CNS (ventral tegmental area); Rat; 1002; 10 days; Controls received mp w/ vehicle; comparison of CSF/CNS micro injections vs. mp; animal info (male, Sprague Dawley, 280-340 g.); behavioral testing (place preference conditioning, locomotor activity); compound also known as 6-cyano-7-nitroquinoxaline-2, 3-dione; opiate addiction.

P9299 Stirling,D.P., Liu,J., Plunet,W., Steeves,J.D., Tetzlaff,W. SB203580, a p38 mitogen-activated protein kinase inhibitor, fails to improve functional outcome following a moderate spinal cord injury in rat. Neuroscience 2008; 155(-1-):128-137. >>> SB203580; DMSO; streptomycin; penicillin; CSF/CNS (subarachnoid space); Rat; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig 5); enzyme inhibitor (p38 MAP Kinase); animal info (male, Wistar, adult, SCI); behavioral testing (locomotor activity).

P9150 Sugiyama,S., Di Nardo,A.A., Aizawa,S., Matsuo,I., Volovitch,M., Prochiantz,A., Hensch,T.K. Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity. Cell 2008; 134(-3-):508-520. >>> Otx2, protein; antibody, inhibitory otx2; RNA, small interfering, penetratin coupled; CSF/CNS (visual cortex); Mice (transgenic); 1007D; 7 days; Controls received mp w/ vehicle; animal info (Otx2 KO); Otx2 is a homeoprotein.

P9690 Thompson,C.K., Brenowitz,E.A. Caspase inhibitor infusion protects an avian song control circuit from seasonal-like neurodegeneration. Journal of Neuroscience 2008; 28(-28-):7130-7136. >>> Z-VAD; Z-DEVD-FMK; Z-LEHD; Z-FA-FMK; DMSO; CSF/CNS (telencephalon); Bird (sparrow); 1, 3, 7 days; Negative controls received mp w/ Z-FA-FMK; good methods (pg 3); animal info (white-crowned, male); 1% DMSO used; pumps externalized via backpack; brain tissue distribution.

P9721 van Groen,T., Wiesehann,K., Funke,S.A., Kadish,I., Nagel-Steger,L., Willbold,D. Reduction of Alzheimer's Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display. ChemMedChem 2008; 3(-12-):1848-1852. >>> FITC-D3; FITC-D1; CSF/CNS (hippocampus); Mice (transgenic); 31 days; Controls received mp w/D1, or saline; peptides; animal info (APPswe/PS1) E9; neurodegenerative (Alzheimer's disease); D-3 is a novel D-enantiomeric amino acid peptide.

P8690 Vetencourt,J.F.M., Sale,A., Viegi,A., Baroncelli,L., De Pasquale,R., O'Leary,O.F., Castren,E., Maffei,L. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 2008; 320(-5874-):385-388. >>> Brain-derived neurotrophic factor; CSF/CNS (intracortical); Rat; 1 week.

P9175 Yoshimura,Y., Inaba,M., Yamada,K., Kurotani,T., Begum,T., Reza,F., Maruyama,T., Komatsu,Y. Involvement of T-type Ca2+ channels in the potentiation of synaptic and visual responses during the critical period in rat visual cortex. European Journal of Neuroscience 2008; 28(-4-):730-743. >>> Mibefradil; Saline; CSF/CNS (visual cortex); Rat; 2001; ; Animal info (Long Evans, PD 25-30); 30 gauge cannula used; mibefradil is a voltage gated calcium channel (VGCC) blocker.

P9206 Zagorac,D., Jakovcevic,D., Gebremedhin,D., Harder,D.R. Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme. Journal of Cerebral Blood Flow and Metabolism 2008; 28(-8-):1431-1439. >>> Miconazole; octadecynoic acid, 17-; Ethanol; CSF, artificial; CSF/CNS (intratumoral); Rat; 1002; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (CYP epoxygenase); tissue perfusion (tumor); ALZET brain infusion kit used; animal info (male, Fisher, 8-10 wks old); 10% ethanol used; antiangiogenesis.