References on the Administration of BrdU Using ALZET^® Osmotic Pumps

Q0645 Leong,S.Y., Faux,C.H., Turbic,A., Dixon,K.J., Turnley,A.M. The Rho Kinase Pathway Regulates Mouse Adult Neural Precursor Cell Migration. Stem Cells 2011; 29(-2-):332-343. >>> Uridine, bromodeoxy; Y27632; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ BrdU only; animal info (6-8 wks old, male, C57BL/6).

Q0658 Schupp,N., Kolkhof,P., Queisser,N., Gaertner,S., Schmid,U., Kretschmer,A., Hartmann,E., Oli,R.G., Schaefer,S., Stopper,H. Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats. FASEB Journal 2011; 25(-3-):968-978. >>> Uridine, bromodeoxy; Rat; 1 week; Animal info (male, Crl:CD, Sprague-Dawley); 2ml pump used.

Q0866 Wang,M.A., Ihida-Stansbury,K., Kothapalli,D., Tamby,M.C., Yu,Z., Chen,L.H., Grant,G., Cheng,Y., Lawson,J.A., Assoian,R.K., Jones,P.L., FitzGerald,G.A. Microsomal Prostaglandin E(2) Synthase-1 Modulates the Response to Vascular Injury. Circulation 2011; 126(-6-):631-U181. >>> Uridine, bromodeoxy; SC; Mice; 2002; ; Animal info (mPGES-1 KO, wt).

Q0897 Yoshida,Y., Fukuda,N., Maeshima,A., Yamamoto,C., Matsumoto,T., Ueno,T., Nojima,Y., Matsumoto,K., Soma,M. Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats. Journal of Hypertension 2011; 29(-1-):91-101. >>> Angiotensin II; uridine, bromodeoxy; SC; IP; Rat; 1, 2 weeks; Animal info (Wistar Kyoto); peptides; systolic blood pressure was measured by tail-cuff (BO-98A; Softron Co).

Q0337 Andersen,M.E., Clewell,HJ III, Bermudez,E., Dodd,D.E., Willson,G.A., Campbell,J.L., Thomas,R.S. Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound. TOXICOLOGICAL SCIENCES 2010; 118(-2-):716-731. >>> Uridine, bromodeoxy; Rat; 2ML1; 3 days; Animal info (male, (F344)/CrlBR, 6-7 wks old); labelling of the duodenum.

Q0347 Cunningham,M.L., Collins,B.J., Hejtmancik,M.R., Herbert,R.A., Travlos,G.S., Vallant,M.K., Stout,M.D. Effects of the PPAR-alpha Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism. PPAR Research 2010; ;(-;-):U1-U14. >>> Uridine, bromodeoxy; Sodium hydroxide; SC; Rat; mice; hamster; 2001; 5 days; Labeling of hepatocytes.

Q0305 Elcombe,C.R., Elcombe,B.M., Foster,J.R., Farrar,D.G., Jung,R., Chang,S.C., Kennedy,G.L., Butenhoff,J.L. Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR-alpha; and CAR/PXR. Archives of Toxicology 2010; 84(-10-):787-798. >>> Uridine, bromodeoxy; PBS; Rat; 2ML1; 5 days; Animal info (male, 7-8 wks old Sprague Dawley); labeling of hepatic S-phase.

Q0841 Masunaga,S., Matsumoto,Y., Kashino,G., Hirayama,R., Liu,Y., Tanaka,H., Sakurai,Y., Suzuki,M., Kinashi,Y., Maruhashi,A., Ono,K. Significance of manipulating tumour hypoxia and radiation dose rate in terms of local tumour response and lung metastatic potential, referring to the response of quiescent cell populations. British Journal of Radiology 2010; 83(-993-):776-784. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; 6 days; Animal info (8 wks old, syngenic, female, C57BL/6); labeling of P cells.

Q0206 Masunaga,S., Tano,K., Nakamura,J., Watanabe,M., Kashino,G., Takahashi,A., Tanaka,H., Suzuki,M., Ohnishi,K., Kinashi,Y., Liu,Y., Ohnishi,T., Ono,K. Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status. Journal of Radiation Research 2010; 51(-1-):27-35. >>> Uridine, bromodeoxy; hexamethylenetetramine; Saline, physiological; SC; Mice (nude); 2001D; 2001; 7 days; 24 hours; Cancer; toxicology; animal info (6-7 weeks old, female, syngenic, Balb/Ca); labeling of P cells.

Q0860 Masunaga,S.I., Tano,K., Nakamura,J., Watanabe,M., Kashino,G., Suzuki,M., Kinashi,Y., Ono,K. Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine compared to its effect combined with tirapazamine in the treatment of solid tumors. EXPERIMENTAL AND THERAPEUTIC MEDICINE 2010; 1(-1-):169-174. >>> Uridine, 2-bromodeoxy 5-; tirapazamine; hexamethylenetetramine; Saline, physiological; SC; IP; Mice; 5 days; 24 hours; Animal info (syngeneic female C3H/He, 8-11 wks old); comparison of IP injections vs mp; cancer; labelling of P cells; "Continuous administration of HMTA and TPZ resulted in higher radio- and cisplatin-sensitizing effects than intraperitoneal single administration." pg 169.

Q0141 Oki,K., Kaneko,N., Kanki,H., Imai,T., Suzuki,N., Sawamoto,K., Okano,H. Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia. NEUROSCIENCE RESEARCH 2010; 66(-4-):390-395. >>> Uridine, bromodeoxy; SC; Mice; 1003D; 48 hours; Animal info (adult, 8-9 weeks old, B6, 23-27 g); labeling of MSI-1 positive cells; MCAO.

Q0180 Pierce,A.A., Xu,A.W. De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance. Journal of Neuroscience 2010; 30(-2-):723-730. >>> Ara-C; uridine, 5' bromodeoxy; CSF, artificial; BSA; CSF/CNS; Mice (transgenic); 2006; 4, 6 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit; animal info (male, wt, AgRP-Tfam, 12 weeks old); functionality of mp verified by residual volume; cannula placement confirmed histologically.

P9912 Rozenberg,I., Sluka,S.H.M., Rohrer,L., Hofmann,J., Becher,B., Akhmedov,A., Soliz,J., Mocharla,P., Boren,J., Johansen,P., Steffel,J., Watanabe,T., Luescher,T.F., Tanner,F.C. Histamine H1 Receptor Promotes Atherosclerotic Lesion Formation by Increasing Vascular Permeability for Low-Density Lipoproteins. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010; 30(-5-):923-U92. >>> Uridine, bromodeoxy; SC; Mice; 1007D; 7 days; Animal info (6 weeks old, ApoE -/-).

Q0094 Sun,Y., Fujigaki,Y., Sakakima,M., Hishida,A. Acquired resistance to rechallenge injury in rats recovered from subclinical renal damage with uranyl acetate-Importance of proliferative activity of tubular cells. TOXICOLOGY AND APPLIED PHARMACOLOGY 2010; 243(-1-):104-110. >>> Uridine, bromodeoxy; Saline; SC; Rat; 2ML1; 1, 2 weeks; Pumps replaced after 1 week; animal info (male, Sprague Dawley, 230-280 g.); labeling of PT cells.

Q0791 Verdeguer,F., Le Corre,S., Fischer,E., Callens,C., Garbay,S., Doyen,A., Igarashi,P., Terzi,F., Pontoglio,M. A mitotic transcriptional switch in polycystic kidney disease. Nature Medicine 2010; 16(-1-):106-U143. >>> Uridine, bromodeoxy; Mice; 2 weeks; Animal info (Hnf1bflox/flox, wt).

Q0196 Wu,X.L., Ge,H.F., Lemon,B., Vonderfecht,S., Weiszmann,J., Hecht,R., Gupte,J., Hager,T., Wang,Z.L., Lindberg,R., Li,Y. FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation. Journal of Biological Chemistry 2010; 285(-8-):5165-5170. >>> Uridine, 5-bromo-2'-deoxy-; SC; Mice; 1007D; 6 days; Animal info (female, FVB, 8 weeks old).

Q0555 Coronella,J., Li,L.N., Johnson,K., Pirie-Shepherd,S., Roxas,G., Levin,N. Selective Activity Against Proliferating Tumor Endothelial Cells by CVX-22, A Thrombospondin-1 Mimetic CovX-BodyTM. Anticancer Research 2009; 29(-6-):2243-2252. >>> Uridine, bromodeoxy; SC; Mice; 2001D; 24 hours; Animal info (male, Swiss Webster); labeling of endothelial cells.

P9645 Deguchi,Y., Yamada,T., Hirose,Y., Nagahori,H., Kushida,M., Sumida,K., Sukata,T., Tomigahara,Y., Nishioka,K., Uwagawa,S., Kawamura,S., Okuno,Y. Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation. TOXICOLOGICAL SCIENCES 2009; 108(-1-):69-80. >>> Uridine, bromodeoxy-; SC; Rat; 7 days; Animal info (male, female, 9 wks old).

R0261 Hirabayashi,Y., Inoue,T. Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells. Biochemical Pharmacology 2009; 77(-4-):521-535. >>> Uridine, 5-bromo-2'-deoxy-; Mice; 3, 7 days; Animal info (AhR+/+, AhR -/-); Review, see pg. 529 (Ref.#32, 80)BUUV Method.

P9576 Jeong,J.O., Kim,M.O., Kim,H., Lee,M.Y., Kim,S.W., Ii,M., Lee,J.U., Lee,J., Choi,Y.J., Cho,H.J., Lee,N., Silver,M., Wecker,A., Kim,D.W., Yoon,Y.S. Dual Angiogenic and Neurotrophic Effects of Bone Marrow-Derived Endothelial Progenitor Cells on Diabetic Neuropathy. Circulation 2009; 119(-5-):699-U93. >>> Uridine, bromodeoxy-; SC; Mice; 4 weeks; Animal info (C57BL/6J, 6 wks old, male).

P9591 Khan,M.D.H., Klein,D., Mossbrugger,I., Oesterle,D., Csanady,G.A., Quintanilla-Martinez,L., Filser,J.G. Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol?. TOXICOLOGY LETTERS 2009; 185(-3-):203-210. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; ; Animal Info (male, Fischer, 238g).

Q0719 Liu,M.T., Kuan,Y.H., Wang,J.W., Hen,R., Gershon,M.D. 5-HT(4) Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. Journal of Neuroscience 2009; 29(-31-):9683-9699. >>> Uridine, bromodeoxy; Saline, alkaline; IP; Mice; 1007D; 7 days; animal info (6-8 wks old, adult, male, 5-HT4 +/-, KO).

P9349 Luque,R.M., Soares,B.S., Peng,X.D., Krishnan,S., Cordoba-Chacon,J., Frohman,L.A., Kineman,R.D. Use of the Metallothionein Promoter-Human Growth Hormone-Releasing Hormone (GHRH) Mouse to Identify Regulatory Pathways that Suppress Pituitary Somatotrope Hyperplasia and Adenoma Formation due to GHRH-Receptor Hyperactivation. Endocrinology 2009; 150(-7-):3177-3185. >>> Uridine, bromodeoxy; SC; Mice (transgenic); 72 hours; Animal info (Tg, 4 months old).

Q0534 Ma-Hock,L., Burkhardt,S., Strauss,V., Gamer,A.O., Wiench,K., van Ravenzwaay,B., Landsiedel,R. Development of a Short-Term Inhalation Test in the Rat Using Nano-Titanium Dioxide as a Model Substance. INHALATION TOXICOLOGY 2009; 21(-2-):102-118. >>> Uridine, bromodeoxy; SC; Rat; 2ML1; 5 days; Animal info (male, Wistar, 7 wks old); labeling of lung cells.

P9832 Martins,K.J.B., Murdoch,G.K., Shu,Y., Harris,R.L.W., Gallo,M., Dixon,W.T., Foxcroft,G.R., Gordon,T., Putman,C.T. Satellite cell ablation attenuates short-term fast-to-slow fibre type transformations in rat fast-twitch skeletal muscle. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2009; 458(-2-):325-335. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 10 days; Pumps replaced after 1 week; animal info (adult, male, Wistar, 320 g.).

P9534 Masunaga,S., Tano,K., Watanabe,M., Kashino,G., Suzuki,M., Kinashi,Y., Ono,K., Nakamura,J. Evaluation of the potential of hexamethylenetetramine, compared with tirapazamine, as a combined agent with gamma-irradiation and cisplatin treatment in vivo. British Journal of Radiology 2009; 82(-977-):392-400. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; ; Animal info (female, syngenic, 22g).

P9692 Masunaga,S., Hirayama,R., Uzawa,A., Kashino,G., Suzuki,M., Kinashi,Y., Liu,Y., Koike,S., Ando,K., Ono,K. The effect of post-irradiation tumor oxygenation status on recovery from radiation-induced damage in vivo: with reference to that in quiescent cell populations. Journal of Cancer Research and Clinical Oncology 2009; 135(-8-):1109-1116. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 5 days; Cancer; animal info (9 wks old, female, syngenic, C3H/He).

Q0533 Masunaga,S.I., Kono,K., Nakamura,J., Tano,K., Yoshida,H., Watanabe,M., Kashino,G., Suzuki,M., Kinashi,Y., Liu,Y., Ono,K. Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells. Oncology Reports 2009; 21(-5-):1307-1312. >>> Uridine, bromodeoxy; HMTA; Saline, physiological; SC; IP; Mice; 5 days; 24 hours; Animal info (8-11 wks old, syngeneic, female, C3H/He, 22.1 g); labelling of P cells; HMTA also known as hexamethylenetetramine.

P9657 Olabisi,R., Chamberlain,C.S., Petr,S., Steiner,S., Consigny,D., Best,T.M., Vanderby,R.Jr, Schultz,E., Noonan,K.J. The Effects of Botulinum Toxin A on Muscle Histology during Distraction Osteogenesis. Journal of Orthopaedic Research 2009; 27(-3-):310-317. >>> Uridine, bromodeoxy-; DMSO; water; SC; Rabbit; 2ML4; 8 weeks; Pumps replaced after 4 wks; animal info (New England, Sheletalby, mature, 3.3-3.9).

Q0364 Oslund,K.L., Hyde,D.M., Putney,L.F., Alfaro,M.F., Walby,W.F., Tyler,N.K., Schelegle,E.S. Activation of Calcitonin Gene-Related Peptide Receptor during Ozone Inhalation Contributes to Airway Epithelial Injury and Repair. Toxicologic Pathology 2009; 37(-6-):805-813. >>> Uridine, bromodeoxy; C-2806 8-37; NaOH; IV (jugular); SC; Rat; 2001D; ; Controls received mp w/ sterile saline; animal info (male, Wistar, 200-250 g); peptide; multiple pumps per animal (2); C-2806 8-37 is a CGRP receptor antagonist; wound clips used; labeling of airway epithelium.

P9938 Stemmer,K., Ellinger-Ziegelbauer,H., Ahr,H.J., Dietrich,D.R. Molecular Characterization of Preneoplastic Lesions Provides Insight on the Development of Renal Tumors. American Journal of Pathology 2009; 175(-4-):1686-1698. >>> Uridine, bromodeoxy; Saline, sterile; SC; Rat; 2ML1; ; Animal info (eker, 10-12 wks).

P9925 Zemke,A.C., Teisanu,R.M., Giangreco,A., Drake,J.A., Brockway,B.L., Reynolds,S.D., Stripp,B.R. beta-Catenin Is Not Necessary for Maintenance or Repair of the Bronchiolar Epithelium. American Journal of Respiratory Cell and Molecular Biology 2009; 41(-5-):535-543. >>> Uridine, bromodeoxy; Saline; SC; Mice; 2002; ; Animal info; (topgal (b6)-congenic, 8-12 wks old, 25-35 g).

Q0381 Zhao,M., Lang,A.M.J. Bromodeoxyuridine infused into the cerebral ventricle of adult mice labels nigral neurons under physiological conditions-A method to detect newborn nerve cells in regions with a low rate of neurogenesis. Journal of Neuroscience Methods 2009; 184(-2-):327-331. >>> Uridine, bromodeoxy; thymidine, 3H; PBS; NaOH; CSF/CNS; IP; Mice; 2004; 1003D; ; Animal info (adult, male, C57BL/6, 10 wks old); labeling of neurons; ALZET brain infusion kit used.

P9387 Andersen,M.E., Clewell,HJ III, Bermudez,E., Willson,G.A., Thomas,R.S. Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat. TOXICOLOGICAL SCIENCES 2008; 105(-2-):368-383. >>> Uridine, bromodeoxy; Rat; 2ML1; 3 days; Toxicology; animal info (male, F344/CrlBR, 8-10 wks old, 200 g.).

P9319 DeAngelo,A.B., Daniel,F.B., Wong,D.M., George,M.H. The induction of hepatocellular neoplasia by trichloroacetic acid administered in the drinking water of the male B6C3F1 mouse. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 2008; 71(-16-):1056-1068. >>> Uridine, bromodeoxy-; thymidine, 3H-; SC; Mice; 2001; 5 days; Cancer (hepatic); toxicology; animal info (B6C3F1, male, 7-107 wks old).

P9650 Hayashi,S., Fujii,E., Kato,A., Kimura,K., Mizoguchi,K., Suzuki,M., Sugimoto,T., Takanashi,H., Itoh,Z., Omura,S., Wanibuchi,H. Characterization of Multinuclear Hepatocytes Induced in Rats by Mitemcinal (GM-611), an Erythromycin Derivative. Toxicologic Pathology 2008; 36(-6-):858-865. >>> Uridine, bromodeoxy-; DMSO; water, distilled; IP; Rat; 2002; 28 days; Pumps replaced after 14 days; animal info (Sprague Dawley, female); multiple pumps per animal (2); 50% DMSO used.

P8813 Kubota,Y., Takubo,K., Suda,T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochemical and Biophysical Research Communications 2008; 366(-2-):335-339. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2004; 2 months; Long-term study; pumps replaced after 28 days; multiple pumps per animal (2); animal info (C57BL/6, 1 month old); labeling of bone marrow LRC's.

P8763 Lassmann,J., Sliwoski,J., Chang,A., Canning,D.A., Zderic,S.A. Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-1-):R58-R65. >>> Uridine, bromodeoxy-; Carbonate solution; SC; Mice; 2004; 4 weeks; Animal info (male, SERCA2, partial bladder outlet obstruction, 8 wks old).

Q0049 Lu,Y., Lohitnavy,M., Reddy,M., Lohitnavy,O., Eickman,E., Ashley,A., Gerjevic,L., Xu,Y., Conolly,R.B., Yang,R.S.H. Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics. Archives of Toxicology 2008; 82(-2-):103-116. >>> Uridine, 5-bromo-2'-deoxy-; SC; Rat; 3 days; Animal info (male, F344, 30 days old, partial hepatectomy).

P9243 Lutgens,E., Tjwa,M., de Frutos,P.G., Wijnands,E., Beckers,L., Dahlbaeck,B., Daemen,M.J.A.P., Carmeliet,P., Moons,L. Genetic loss of Gas6 induces plaque stability in expeximental atherosclerosis. Journal of Pathology 2008; 216(-1-):55-63. >>> Uridine, bromodeoxy-; Mice; 2001; 2 weeks; Cardivascular; animal info (C57/BL6 x 129/sv x Swiss Gas6 -/-: ApoE -/-, Gas6 +/+: ApoE -/-; 23 wks old).

P9793 Makino,T., Ishikawa,K., Igarashi,I., Yamoto,T., Manabe,S., Nakayama,H. Relationship between GST Yp Induction and Hepatocyte Proliferation in Rats Treated with Phase II Drug Metabolizing Enzyme Inducers. Toxicologic Pathology 2008; 36(-3-):420-427. >>> Uridine, bromodeoxy-; DMSO; SC; Rat; 2001; 3, 7 days; Animal info (male, F344/DuCrj); 40% DMSO used.

P9781 Masunaga,S.I., Ando,K., Uzawa,A., Hirayama,R., Furusawa,Y., Koike,S., Ono,K. The radiosensitivity of total and quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo. Acta Oncologica 2008; 47(-6-):1087-1093. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 5 days; Animal info (8-11 wks old, syngenic, female, C3H/He); labelling of P cells.

P9429 Masunaga,S.I., Ando,K., Uzawa,A., Hirayama,R., Furusawa,Y., Koike,S., Ono,K. Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo. Radiation Medicine 2008; 26(-5-):270-277. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old).

P8868 Mziaut,H., Kersting,S., Knoch,K.P., Fan,W.H., Trajkovski,M., Erdmann,K., Bergert,H., Ehehalt,F., Saeger,H.D., Solimena,M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-2-):674-679. >>> Uridine, bromodeoxy-; DMSO; IP; Mice; 1007D; 7 days; Animal info (ICA 512 -/-); 50% DMSO used; diabetes.

P9214 Newberry,E.P., Kennedy,S.M., Xie,Y., Luo,J., Stanley,S.E., Semenkovich,C.F., Crooke,R.M., Graham,M.J., Davidson,N.O. Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology 2008; 48(-4-):1097-1105. >>> Uridine, bromodeoxy-; uridine, fluorodeoxy-; Mice; 1003D; 48, 72 hours; Partial hepatectomy; animal info (10-20 wks old, C57BL/6, PLDKO, PPARa -/-, FAS-KOL, L-Fabp -/-, MTP-IKO).

P9047 Oslund,K.L., Hyde,D.M., Putney,L.F., Alfaro,M.F., Walby,W.F., Tyler,N.K., Schelegle,E.S. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. American Journal of Respiratory Cell and Molecular Biology 2008; 39(-3-):279-288. >>> SR140333; Uridine, bromodeoxy-; Saline, sterile; SC; IV (jugular); Rat; 2001D; 2ML2; ; Controls received mp w/ vehicle; good methods (pg. 280); animal info (male, Wistar); pumps were primed for 3 hours; polyethylene tubing used; incisions were closed with 7.5 mm steel wound clips.

P8788 Ray,J.B., Arab,S., Deng,Y., Liu,P., Penn,L., Courtman,D.W., Ward,M.E. Oxygen regulation of arterial smooth muscle cell proliferation and survival. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H839-H852. >>> Uridine, bromodeoxy-; DMSO; SC; Rat; 2ML2; 48 hours; Animal info (male, Sprague Dawley, 175-200 g.); 0.4% DMSO used.

P9303 Rivers,L.E., Young,K.M., Rizzi,M., Jamen,F., Psachoulia,K., Wade,A., Kessaris,N., Richardson,W.D. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nature Neuroscience 2008; 11(-12-):1392-1401. >>> Uridine, bromodeoxy-; Ammonium solution; SC; Mice (transgenic); 17 days; Controls received mp w/ vehicle; comparison of oral vs. mp; pumps replaced after 9 days; animal info (BAC Tg/Pdfra-cre ER-T2/Rosa 26-YFP, 60 days old).

P9128 Schmiedl,A., Lempa,T., Hoymann,H.G., Rittinghausen,S., Popa,D., Tschernig,T., Fehrenbach,H., Pabst,R., Hoeper,M.M., Hohlfeld,J.M. Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally. VIRCHOWS ARCHIV 2008; 452(-6-):675-688. >>> Uridine, bromodeoxy; SC; Rat; ; Animal info (male, Lewis, 195-230 g.); 2 ml pump used.

P8885 Tharappel,J.C., Spear,B.T., Glauert,H.P. Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-kappaB. TOXICOLOGY AND APPLIED PHARMACOLOGY 2008; 226(-3-):338-344. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 3 days; Animal info (7-8 wks old, B6129, p50 -/-).

P9678 Tharappel,J.C., Lehmler,H.J., Srinivasan,C., Robertson,L.W., Spear,B.T., Glauert,H.P. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food and Chemical Toxicology 2008; 46(-11-):3467-3474. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 3 days; Animal info (female, weanling, Sprague Dawley); labeling of hepatocyte.

P9546 Zhang,W., Zhao,J., Chen,L., Urbanowicz,M.M., Nagasaki,T. Abnormal epithelial homeostasis in the cornea of mice with a destrin deletion. MOLECULAR VISION 2008; 14(-228-):1929-1939. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 2002; 2 weeks; 24 hours; Animal info (GFP-Dstn Corn1, 13-20 wks old).

P8716 Bunaciu,R.P., Tharappel,J.C., Lehmler,H.J., Kania-Korwel,I., Robertson,L.W., Srinivasan,C., Spear,B.T., Glauert,H.P. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 2007; 239(-3-):147-155. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; ; Toxicology; animal info (female, Sprague-Dawley, 100-125g); labeling of hepatocytes.

P8068 Cafaro,J., Lee,G.S., Stone,J.S. Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration. Developmental Dynamics 2007; 236(-1-):156-170. >>> Uridine, bromodeoxy-; PBS; Ear (perilymphatic fluid); Bird (chicken); 2002; 8 days; No stress (see p.167); Alzet brain infusion kit used; animal info (White Legorn, 5-10 days old).

P8535 Gordon,S.E., Westerkamp,C.M., Savage,K.J., Hickner,R.C., George,S.C., Fick,C.A., McCormick,K.M. Basal, but not overload-induced, myonuclear addition is attenuated by NG-initro-L-arginine methyl ester (L-NAME) administration. Canadian Journal of Physiology and Pharmacology 2007; 85(-6-):646-651. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Animal info (female, Sprague-Dawley, 220 g).

P8727 Hsieh,P.C.H., Segers,V.F.M., Davis,M.E., MacGillivray,C., Gannon,J., Molkentin,J.D., Robbins,J., Lee,R.T. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Medicine 2007; 13(-8-):970-974. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 7 days; Animal info (adult, transgenic, MerCreMer-ZEG); labeling of cardiomyocytes.

P8522 Kim,I., Morimura,K., Shah,Y., Yang,Q., Ward,J.M., Gonzalez,F.J. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007; 28(-5-):940-946. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 1 week; Animal info (C57NL/6N, wt, Fxr-null; 3,12 months old).

P8691 Martin,C.D., Jimenez-Andrade,J.M., Ghilardi,J.R., Mantyh,P.W. Organization of a unique net-like meshwork of CGIZP+ sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain. Neuroscience Letters 2007; 427(-3-):148-152. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 24 hours; Animal info (C57BL/6J, 18-25g, male); bone; pain; labeling at the periosteum.

P8203 Masunaga,S., Nagasawa,H., Nagata,K., Suzuki,M., Uto,Y., Hori,H., Kinashi,Y., Ono,K. Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells. Journal of Cancer Research and Clinical Oncology 2007; 133(-1-):47-55. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5, 8 days; Cancer (carcinoma); animal info (female, 8-11 wks old).

P8729 Masunaga,S., Takahashi,A., Ohnishi,K., Nagata,K., Suzuki,M., Kashino,G., Kinashi,Y., Ohnishi,T., Ono,K. Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population. Oncology Reports 2007; 18(-6-):1589-1596. >>> Uridine, bromodeoxy-; Saline; SC; Mice (nude); 2001; 7 days; Tissue perfusion (tumor); cancer; animal info (Balb/cA, nude); labeling of tumor cells.

P8308 Price,R.J., Walters,D.G., Finch,J.M., Gabriel,K.L., Capen,C.C., Osimitz,T.G., Lake,B.G. A mode of action for induction of liver tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2007; 218(-2-):186-195. >>> Uridine, bromodeoxy-; Rat; 2ML1; 7 days; Cancer (liver); toxicology; animal info (male, female, Sprague-Dawley CD, 10-11 wks old); labeling of hepatocytes.

P8963 Sadeu,J.C., Adriaens,I., Cortvrindt,R., Smitz,J. Study of folliculogenesis in vivo in guinea pig. Theriogenology 2007; 68(-9-):1228-1239. >>> Uridine, bromodeoxy; Saline; SC; Guinea-pig; 2ML1; 1, 2 weeks; Animal info (female, Dunkin-Hartley, 560-750); wound clips used.

P8566 Virag,J.A.I., Rolle,M.L., Reece,J., Hardouin,S., Feigl,E.O., Murry,C.E. Fibroblast growth factor-2 regulates myocardial infarct repair - Effects on cell proliferation, scar contraction, and ventricular function. American Journal of Pathology 2007; 171(-5-):1431-1440. >>> Uridine, bromodeoxy-; DMSO; water; SC; Mice (knockout); 1007D; 4 days; Cardiovascular; animal info (FGF2 knockout mice, 6-8 weeks old, 20-30 grams); 50% DMSO 50% water; labeling of endothelial cells.

P7991 Vogetseder,A., Palan,T., Bacic,D., Kaissling,B., Le Hir,M. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2007; 292(-2-):C807-C813. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 1, 2 weeks; Pumps replaced every 7 days for two week studies; animal info (male, Wistar, 4-5 weeks old, 110-140 grams); labeling of kidney.

P8502 Yang,Q., Ito,S., Gonzalez,F.J. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis 2007/6; 28(-6-):1171-1177. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2001; 1 week; labeling of hepatocytes; animal info (transgenic).

P8099 Bernstein,D.M., Rogers,R., Smith,P., Chevalier,J. The toxicological response of Brazilian chrysotile asbestos: A multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response. INHALATION TOXICOLOGY 2006; 18(-5-):313-332. >>> Uridine, bromodeoxy-; SC; Rat; 2001; 3 days; Toxicology; animal info (male, Wistar Han-Ibm, 9 wk old).

P7671 Campbell,J.S., Riehle,K.J., Brooling,J.T., Bauer,R.L., Mitchell,C., Fausto,N. Proinflammatory cytokine production in. liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. Journal of Immunology 2006; 176(-4-):2522-2528. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 48 hours; Comparison of IP injection vs. mp; animal info (C57BL/6, KO, heterozygous, male, 11 wk old); labeling of hepatocytes.

P7887 Dedkov,E.I., Zheng,W., Tomanek,R.J. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. American Journal of Physiology-Heart and Circulatory Physiology 2006; 291(-4-):H1686-H1693. >>> Uridine, bromodeoxy-; Rat; 72 hours; Cardiovascular; animal info (male, Sprague-Dawley, 12 month old); left coronary artery ligation to induce MI; labeling of coronary arterioles (endothelial cells of the coronary arterioles).

P8135 Finch,J.M., Osimitz,T.G., Gabriel,K.L., Martin,T., Henderson,W.J., Capen,C.C., Butler,W.H., Lake,B.G. A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2006; 214(-3-):253-262. >>> Uridine, bromodeoxy-; 2ML1; 7, 14 days; Pumps replaced after 7 days; animal info (male, female, Sprague-Dawley CD, 10-11 wks old, 450-500g., 250-300g.).

P7738 Hyatt,J.P.K., Roy,R.R., Baldwin,K.M., Wernig,A., Edgerton,V.R. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle&Nerve 2006; 33(-1-):49-60. >>> Uridine, bromodeoxy-; SC; Rat; 2ML2; 14 days; Animal info (female, Sprague-Dawley, 200-235g.; denervation or spinal cord isolation); labeling of satellite cells.

P8898 Maeshima,A., Sakurai,H., Nigam,S.K. Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. Journal of the American Society of Nephrology 2006; 17(-1-):188-198. >>> Uridine, bromodeoxy-; IP; Rat; 1 week; Animal info (male, Sprague Dawley, 7 wks old, 240 g.); ischemia (kidney); nephrology.

P7796 Martins,K.J.B., Gordon,T., Pette,D., Dixon,W.T., Foxcroft,G.R., MacLean,I.M., Putman,C.T. Effect of satellite cell ablation on low-frequency-stimulated fast-to-slow fibre-type transitions in rat skeletal muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 572(-1-):281-294. >>> Uridine, bromodeoxy-; SC; Rat; 2004; 21 days; Animal info (male, Wistar, 296g.); labeling of satellite cells.

P9057 Masunaga,S., Sakurai,Y., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Nagasawa,H., Uto,Y., Hori,H., Ono,K. The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons. British Journal of Radiology 2006; 79(-948-):991-998. >>> Uridine, bromodeoxy-; tirapazamine; Saline; SC; Mice; 2001D; 5 days; 24 hours; Tissue perfusion (tumor); comparison of IP injections vs. mp; cancer; animal info (8-11 wks old, female, syngenic C3H, He); tirapazamine, also known as TP2, is a lead compound as a bioreactive hypoxic cytotoxin; labing of P cells; cancer.

P8169 Masunaga,S.I., Uto,Y., Nagasawa,H., Hori,H., Nagata,K., Suzuki,M., Kinashi,Y., Ono,K. Evaluation of hypoxic cell radio-sensitizers in terms of radio-sensitizing and repair-inhibiting potential. dependency on p53 status of tumor cells and the effects on intratumor quiescent cells. Anticancer Research 2006; 26(-2A-):1261-1270. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice (nude); 5, 7 days; Cancer (squamous cell carcinoma); animal info (BALB/cA, C3H/He, 6-7 weeks old, 22 grams); labeling of tumor 'P' cells.

P8209 Masunaga,S.I., Kasaoka,S., Maruyama,K., Nigg,D., Sakurai,Y., Nagata,K., Suzuki,M., Kinashi,Y., Maruhashi,A., Ono,K. The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2006; 66(-5-):1515-1522. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old, 20-25g.).

P8982 Masunaga,S.I., Nagasawa,H., Sakurai,Y., Uto,Y., Hori,H., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Ono,K. The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy. International Journal of Hyperthermia 2006; 22(-4-):287-299. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old).

P7623 Ohyama,M., Terunuma,A., Tock,C.L., Radonovich,M.F., Pise-Masison,C.A., Hopping,S.B., Brady,J.N., Udey,M.C., Vogel,J.C. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. Journal of Clinical Investigation 2006; 116(-1-):249-260. >>> Uridine, bromodeoxy-; SC; Mice (nude); 1002; 4-6 weeks; Pumps replaced every 2 weeks; multiple pumps per animal (2).

P8983 Ott,T., Jokwitz,M., Lenhard,D., Romualdi,A., Dombrowski,F., Ittrich,C., Schwarz,M., Willecke,K. Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis. European Journal of Cell Biology 2006; 85(-8-):717-728. >>> Uridine, bromodeoxy-; Mice; 1003D; 3 days; Cancer (breast, liver); animal info (male, C57BL/6-129sv, wt, Cx32 -/-, Cx26, FL/FL, Cx26 FL/FL:AlfpCre); "BrdU was applied by osmotic pumps over a period of 3 days to avoid diurnal variation in proliferation." (p. 720).

P7801 Overstreet-Wadiche,L.S., Bromberg,D.A., Bensen,A.L., Westbrook,G.L. Seizures accelerate functional integration of adult-generated granule cells. Journal of Neuroscience 2006; 26(-15-):4095-4103. >>> Uridine, bromodeoxy-; Saline; NaOH; SC; Mice (transgenic); 2001D; 1 day; Animal info (adult, -13/+8POMC-EGFP Tg.); labeling of granule cells.

P7786 Pauluhn,J., Mohr,U. Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose-only inhalation study in rats. Journal of Applied Toxicology 2006; 26(-3-):279-292. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 7 days; Animal info (male, Wistar, 5 months old); labeling of lung cells (alveolar, epithelial).

P8348 Rudnick,D.A., Shikapwashya,O., Blomenkamp,K., Teckman,J.H. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology 2006; 44(-4-):976-982. >>> Uridine, bromodeoxy-; IP; Mice; 72 hours; Animal info (male, C57BL/6J-piz, 6-12 months old).

P7794 Schrier,L., Ferns,S.P., Barnes,K.M., Emons,J.A.M., Newman,E.I., Nilsson,O., Baron,J. Depletion of resting zone chondrocytes during growth plate senescence. Journal of Endocrinology 2006; 189(-1-):27-36. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Rabbit; rabbit (pregnant); 2ML1; 1 week; Controls did not receive BrdU; animal info (New Zealand White, male; 5, 9&17 wk. old, female, pregnant); endocrinology; labeling of chondocytes.

P7930 Voss,K.A., Riley,R., Dunn,C., Corton,J.C. The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. Toxicology 2006; 222(-3-):165-174. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; animal info (male, 1.5 weeks old); labeling of hepatocytes.

P7510 Voss,K.A., Liu,J., Anderson,S.P., Dunn,C., Miller,J.D., Owen,J.R., Riley,R.T., Bacon,C.W., Corton,J.C. Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. TOXICOLOGICAL SCIENCES 2006; 89(-1-):108-119. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; No stress (see pg. 111); animal info (female, SV129, 20-22 g); labeling of hepatocytes.

P7630 Bauer,S., Patterson,P.H. The cell cycle-apoptosis connection revisited in the adult brain. Journal of Cell Biology 2005; 171(-4-):641-650. >>> Uridine, bromodeoxy-; Saline; CSF/CNS; Mice; 1003D; 24 hours; ALZET Brain Infusion Kit 2 used; animal info (2-4 month old, C57BL/6).

P7296 Budak,M.T., Alpdogan,O.S., Zhou,M.Y., Lavker,R.M., Akinci,M.A.M., Wolosin,J.M. Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. Journal of Cell Science 2005; 118(-8-):1715-1724. >>> Uridine, bromodeoxy-; SC; Rabbit; 2ML2; 14-16 days; Labeling of the ocular surface.

P7126 Bursch,W., Wastl,U., Hufnagl,K., Schulte-Hermann,R. No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction. TOXICOLOGICAL SCIENCES 2005; 85(-1-):507-514. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 1003D; 2001; ; Labeling of hepatocytes.

P7384 Currie,R.A., Bombail,V., Oliver,J.D., Moore,D.J., Lim,F.L., Gwilliam,V., Kimber,I., Chipman,K., Moggs,J.G., Orphanides,G. Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: Application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate. TOXICOLOGICAL SCIENCES 2005; 86(-2-):453-469. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 48,72 hours; Animal info (B6C3F1, male, 7-10 wks); labeling of hepatocytes.

P7452 Elder,A., Gelein,R., Finkelstein,J.N., Driscoll,K.E., Harkema,J., Oberdoerster,G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. TOXICOLOGICAL SCIENCES 2005; 88(-2-):614-629. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 5 days; Animal info (female f-344 rat; female b6c3f1 mice; female 276f1b syrian golden hamster); labeling of lung cells.

P7239 Farah,M.H., Easter,SS Jr  Journal of Comparative Neurology 2005; 489(-1-):120-134. >>> Uridine, bromodeoxy-; SC; Mice (pregnant); 2001; 1-7 days; Teratology.

P7444 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Noakes,J. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 1: Mode of action studies in the mouse. TOXICOLOGICAL SCIENCES 2005; 86(-1-):36-47. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Mice; 1003D; 3 days; Cancer (hepatic); toxicology; animal info (male, 30-43 g); labeling of hepatocytes.

P7441 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Peffer,R., Noakes,J., Robinson,M. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 2: Species differences in response. TOXICOLOGICAL SCIENCES 2005; 86(-1-):48-55. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 3 days; Cancer (hepatic); toxicology; animal info (female, 140-160 g).

P7240 Hayashi,S., Asahara,T., Masuda,H., Isner,J.M., Losordo,D.W. Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization. Circulation 2005; 111(-17-):2210-2218. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; cardiovascular; ischemia (hindlimb).

P7269 Huss,W.J., Gray,D.R., Greenberg,N.M., Mohler,J.L., Smith,G.J. Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells. Cancer Research 2005; 65(-15-):6640-6650. >>> Uridine, bromodeoxy-; Mice (transgenic); 2002; 2 weeks; Cancer (prostate); labeling of the prostate.

P8093 Kai,K., Yoshida,M., Sugawara,T., Kato,M., Uchida,K., Yamaguchi,R., Tateyama,S., Furuhuma,K. Investigation of initial changes in the mouse olfactory epithelium following a single intravenous injection of vincristine sulphate. Toxicologic Pathology 2005; 33(-7-):750-759. >>> Uridine, bromodeoxy-; SC; Mice; 2001D; 6, 24 hours; Animal Info (male, BALB/c, 8 wks. old); vincristine or unilateral bubectomy.

P7232 Karam,S.M., John,R., Alpers,D.H., Ponery,A.S. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23(-3-):433-441. >>> Retinoic acid; uridine, bromodeoxy-; SC; Mice; 1, 3, 6 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; cancer (gastric); multiple pumps per animal (2).

P7593 Kaufmann,W., Mellert,W., van Ravenzwaay,B., Landsiedel,R., Poole,A. Effects of styrene and its metabolites on different lung compartments of the mouse - cell proliferation and histomorphology. Regulatory Toxicology and Pharmacology 2005; 42(-1-):24-36. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 2001; ; Cancer; toxicology; animal info (female, CD1, 49 days old); labeling of lung cells.

P8234 Keenan,K.P., Hoe,C.M., Mixson,L., McCoy,C.L., Coleman,J.B., Mattson,B.A., Ballam,G.A., Gumprecht,L.A., Soper,K.A. Diabesity: A polygenic model of dietary-induced obesity from ad libitum overfeeding of Sprague-Dawley rats and its modulation by moderate and marked dietary restriction. Toxicologic Pathology 2005; 33(-6-):650-674. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 7 days; Toxicology; animal info (male, female, Sprague-Dawley, 12, 25, or 52 weeks old).

P7326 Kishore,R., Qin,G.J., Luedemann,C., Bord,E., Hanley,A., Silver,M., Gavin,M., Goukassain,D., Losordo,D.W. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. Journal of Clinical Investigation 2005; 115(-7-):1785-1796. >>> Uridine, bromodeoxy-; Mice (nude); 7 days; Cardiovascular; ischemia (hindlimb); labeling of ischemic hind limb muscle.

P8065 Kronenberg,G., Wang,L.P., Synowitz,M., Gertz,K., Katchanov,J., Glass,R., Harms,C., Kempermann,G., Kettenmann,H., Endres,M. Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia. Journal of Cerebral Blood Flow and Metabolism 2005; 25(-12-):1613-1624. >>> Uridine, bromodeoxy-; SC; Mice; mice (transgenic); 4 days; Ischemia (cerebral); animal info (C57BL/6 nestin-GFP tg, 10-12 wk old, 20-25g, MCAO); "this dose is nontoxic and labels approximately 4 times more cells after cerebral ischemia than twice daily intraperitoneal injections" (p.1614).

P6968 Matsusaka,T., Xin,J., Niwa,S., Kobayashi,K., Akatsuka,A., Hashizume,H., Wang,Q.C., Pastan,I., Fogo,A.B., Ichikawa,I. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. Journal of the American Society of Nephrology 2005; 16(-4-):1013-1023. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2002; 14 days; Labeling of interstitial cells.

P7368 Mohapel,P., Frielingsdorf,H., Haeggblad,J., Zachrisson,O., Brundin,P. Platelet-derived growth factor (PDGF-BB) and brainderived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience 2005; 132(-3-):767-776. >>> Platelet-derived growth factor-BB; brain-derived neurotrophic factor; uridine, bromodeoxy-; PBS; CSF/CNS; Rat; 2002; 10 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit used; neurodegenerative (parkinson's disease); labeling of striatum.

P8095 Ohashi,K., Kay,M.A., Yokoyama,T., Kuge,H., Kanehiro,H., Hisanaga,M., Ko,S., Nakajima,Y. Stability and repeat regeneration potential of the engineered liver tissues under the kidney capsule in mice. CELL TRANSPLANTATION 2005; 14(-9-):621-627. >>> Uridine, bromodeoxy-; Mice; 2001; 2 weeks; Animal info (FVB/N, partial hepatectomy, hepatocyte transplantation); labeling of hepatocytes.

P7580 Poluektova,L., Meyer,V., Walters,L., Paez,X., Gendelman,H.E. Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis. Glia 2005; 52(-4-):344-353. >>> Uridine, bromodeoxy-; Saline, physiological; CSF/CNS; Mice (SCID); 2004; 7, 28 days; Animal info (SCID, 4 wk old, male).

P7408 Rissler,P., Soederdahl,G., Nordman,T., Xia,L., Torndal,U.B., Bjoernstedt,M., Ericzon,B.G., Olsson,J.M., Eriksson,L.C. Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation. TRANSPLANT INTERNATIONAL 2005; 18(-8-):992-1000. >>> Uridine, bromodeoxy-; NaOH; SC; Rat; ; Labeling of hepatocytes; animal info (male, wistar-kyoto, 4-5 weeks old, 110 g).

P7409 Roy,S.K., Thilagar,A.K., Eastmond,D.A. Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2005; 586(-1-):28-37. >>> Uridine, bromodeoxy-; SC; Mice; 5 days; Labeling of hepatocytes; animal info (21 days old, CD-1, male).

P7459 Sales,V.L., Sukhova,G.K., Lopez-Ilasaca,Ma, Libby,P., Dzau,V.J., Pratt,R.E. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 2005; 112(-21-):3328-3336. >>> Uridine, bromodeoxy-; SC; IP; Mice; 2001; 7 days; Cardiovascular; animal info (male, C57 BL/6J, high cholesterol diet).

P7355 Smith,G.H. Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development 2005; 132(-4-):681-687. >>> Uridine, bromodeoxy-; Mice; 14 days; Labeling of mammary cells.

P7311 Yang,P., Baker,K.A., Hagg,T. A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS. Journal of Comparative Neurology 2005; 490(-2-):163-179. >>> Uridine, bromodeoxy-; IP; Rat; 2ML2; 14 days; Labeling of subventricular zone (SVZ).

P7337 Yoon,Y.S., Wecker,A., Heyd,L., Park,J.S., Tkebuchava,T., Kusano,K., Hanley,A., Scadova,H., Qin,G.J., Cha,D.H., Johnson,K.L., Aikawa,R., Asahara,T., Losordo,D.W. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. Journal of Clinical Investigation 2005; 115(-2-):326-338. >>> Uridine, bromodeoxy-; DMSO; NaCl; SC; Rat (nude); 2ML4; 4 weeks; Ischemia (cardiac); Labeling of myocardial cells; 50% DMSO used.