References on the Administration of BrdU Using ALZET® Osmotic Pumps

16329 Douvaras, P., Dora, N. J., Mort, R. L., Lodge, E. J., Hill, R. E., West, J. D. Abnormal corneal epithelial maintenance in mice heterozygous for the micropinna microphthalmia mutation Mp. Exp Eye Res 2016; 149(--):26-39. >>> Uridine, Bromodeoxy-; Saline; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (15-week old Mp/+ mice); functionality of mp verified by corneal imaging; Dose (50 mg/ml);.

16285 Di Siena, S., Gimmelli, R., Nori, S. L., Barbagallo, F., Campolo, F., Dolci, S., Rossi, P., Venneri, M. A., Giannetta, E., Gianfrilli, D., Feigenbaum, L., Lenzi, A., Naro, F., Cianflone, E., Mancuso, T., Torella, D., Isidori, A. M., Pellegrini, M. Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury. Cell Death Dis 2016; 7(-7-):e2317. >>> Uridine, Bromodeoxy; SC; mice; post op. care (500Ǩl glucose solution (5% glucose/physiologic solution), analgesic Atradol (3 mg/kg); Dose (0.6 M);.

16237 Roche, K. C., Gracz, A. D., Liu, X. F., Newton, V., Akiyama, H., Magness, S. T. SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine. Gastroenterology 2015; 149(-6-):1553-1563 e10. >>> Uridine, 5-ethynyl-2’-deoxy; DMSO, PEG 300; SC; mice; Controls received mp w/ vehicle; animal info (SOX9 knockout mice); functionality of mp verified by Click-it EdU flow cytometry kit; 50% DMSO used, 50% PEG 300; cell proliferation assays; Dose (1.15 mg/ul);.

16236 Robins, S. C., Trudel, E., Rotondi, O., Liu, X., Djogo, T., Kryzskaya, D., Bourque, C. W., Kokoeva, M. V. Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One 2013; 8(-10-):e78236. >>> Uridine, bromodeoxy; uridine, ethynyldeoxy; CSF, artificial; CSF/CNS (right lateral ventricle); mice; 1007D; animal info: NG2-CreER:tdTomato mice; functionality of mp verified post brain removal; Plastics One infusion kit used; brain tissue distribution; delayed delivery (2 days); delayed delivery (2 days); Dose: 30 ug/day (BrdU and EdU); Brain coordinates; 0.3 mm (anteroposterior), 1.0 mm (lateral), and 2.5 mm (dorsoventral, below skull).

16125 Gautier, H. O., Evans, K. A., Volbracht, K., James, R., Sitnikov, S., Lundgaard, I., James, F., Lao-Peregrin, C., Reynolds, R., Franklin, R. J., Karadottir, R. T. Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors. Nat Commun 2015; 6(--):8518. >>> Tetrodotoxin; Conotoxin, MVIIC w-; NBQX; Uridine, ethyldeoxy-; Saline; CSF/CNS; rat; 1004; Controls received mp w/ vehicle; animal info: Female Sprague–Dawley rats aged 10–14 weeks of age (190–250 g); Plastics One brain infusion kit used; good methods; neurodegenerative (demyelination); post op. care (buprenorphine); cyanoacrylate adhesive (pg 12); delayed delivery (3 dpl and 10 dpl), using corn oil to separate drug from saline in a catheter; “The onset of drug delivery into the lesion was controlled by varying the length of the tube that connects the minipump to the cannula and by inserting a sterile corn oil drop (Sigma) to prevent diffusion of the drug solution into the initial saline solution” (pg 12); Dose: 11 mM conotoxin; 50nM tetrodotoxin; 250 uM NBQX; 5 ug/ul EdU.

16115 Dusabineza, A. C., Najimi, M., van Hul, N., Legry, V., Khuu, D. N., van Grunsven, L. A., Sokal, E., Leclercq, I. A. Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model. Cell Transplant 2015; 24(-12-):2557-71. >>> Uridine, bromodeoxy-; IP; mice; 1004; animal info: SCID mice, females, 20–24 g; GFP+ transgenic mice, males, 35–44 g; gene therapy;.

16067 Williams, H., Mill, C. A., Monk, B. A., Hulin-Curtis, S., Johnson, J. L., George, S. J. Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration. Arterioscler Thromb Vasc Biol 2016; 36(-7-):1417-24. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2004; animal info (Wnt2 +/-); cardiovascular;.

16032 Krautz, C., Wolk, S., Steffen, A., Knoch, K. P., Ceglarek, U., Thiery, J., Bornstein, S., Saeger, H. D., Solimena, M., Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 2013; 56(-7-):1596-604. >>> uridine, bromodeoxy- ; tacrolimus; sirolimus; everolimus; mycophenolate mofetil; DMSO; IP; mice; 1004; controls received mp w/ BrdU; animal info: C57BL/6, diabetic mice, transplanted with syngeneic islets in the liver, 10-12 wk old; functionality of mp verified by monitoring drug plasma levels; HPLC-MS/MS; mp were used to infuse immunosuppressant MMF (Mycophenolate Mofetil). Study concluded that MMFneither impaired pancreatic beta cell proliferation, nor adversely affected the fractional beta cell area. Pump mentions 2 mice that had very high Everolimus levels due to malfunction of the pump, and died 7, and 9 days respectively after transplantation; dose: Everolimus (1 mg/kg/d), Tacrolimus (1mg/kg/d); Mycophenolate Mofetil (20mg/kg/d), Sirolimus 90.2 mg/kg/d); BrdU (100 ug/ul);.

16011 Geter, D. R., Bhat, V. S., Gollapudi, B. B., Sura, R., Hester, S. D. Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway. Toxicol Sci 2014; 138(-2-):425-45. >>> uridine, bromodeoxy; saline; mice; 2001; animal info (6 week old male and female CD-1 mice; nulliparous and nonpregnant); cancer (rodent liver tumors); dose-response (dietary test prep section pg 426); PB aka Phenobarbital; BrdU aka Bromodeoxyuridine; Dose: 20 mg/ml BrdU.

15975 LeBaron, M. J., Geter, D. R., Rasoulpour, R. J., Gollapudi, B. B., Thomas, J., Murray, J., Kan, H. L., Wood, A. J., Elcombe, C., Vardy, A., McEwan, J., Terry, C., Billington, R. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects. Toxicol Appl Pharmacol 2013; 270(-2-):164-73. >>> uridine, bromodeoxy-; PBS; SC; mice; 2001; toxicology; animal info: (C57BL/6J; wildtype, knock-out, and humanized); functionality of mp verified by BrdU immunohistochemistry ; cancer (hepatic); MoA; liver tumors; toxicity of agricultural molecule; sulfoxaflor; short-term rodent carcinogenicity study; 15 mg/mL; Industry authored (The Dow Chemical Company, Midland, MI, 48674, USA);.

15743 Su-Ping Chang,, Hamish D. Morrison,, Frida Nilsson,, Christopher J. Kenyon,, John D. West,, Steven D. Morley  PLoS One 2013; 8(-12-):1-15. >>> uridine, bromodeoxy; saline; SC; mice; 1007D; 2002; C57BL/6, 12 weeks old; mp wer used to investigate cell proliferation, movement, and differentiation in mice adrenal cortex via BrdU infusion; 50 mg/ml.

15207 Cordoba-Chacon, J., Gahete, M.D., Pokala, N.K., Geldermann, D., Alba, M., Salvatori, R., Luque, R.M., Kineman, R.D. Long-But Not Short-Term Adult-Onset, Isolated GH Deficiency in Male Mice Leads to Deterioration of beta-Cell Function, Which Cannot Be Accounted for by Changes in beta-Cell Mass. ENDOCRINOLOGY 2014; 155(-3-):726-735. >>> Uridine, bromodeoxy; Mice; Animal info (male, AOiGHD, 12 weeks old);.

15080 Sherstnev, V.V., Gruden', M.A., Golubeva, O.N., Aleksandrov, Y.I., Solov'eva, O.A., Sherstnev, V.V. Long-lived newly formed neurons in the mature brain are involved in the support of learning and memory processes. Neurochemical Journal 2015; 9(--):13-19. >>> Uridine, 5-bromo-2-deoxy-; Saline, sterile; CSF/CNS; Rat; 2002; Animal info (male, Wistar, 12 weeks old, 220-250g); behavioral testing (morris water maze); pumps removed after 14 days;.

15949 Masunaga, S., Sakurai, Y., Tanaka, H., Tano, K., Suzuki, M., Kondo, N., Narabayashi, M., Nakagawa, Y., Watanabe, T., Maruhashi, A., Ono, K. The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy. Springerplus 2014; 3(--):128. >>> Uridine, bromodeoxy-; Saline; SC; Mice; animal info (female, C3H/He, 8-11 weeks old); cancer (SCC VII squamous cell carcinoma);.

15948 Masunaga, S. I., Sakurai, Y., Tano, K., Tanaka, H., Suzuki, M., Kondo, N., Narabayashi, M., Watanabe, T., Nakagawa, Y., Maruhashi, A., Ono, K. Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis. Exp Ther Med 2014; 8(-1-):291-301. >>> uridine, bromodeoxy-; saline; SC; mice; Controls received mp w/ vehicle; animal info (B16-BL6 melanoma tumor-bearing C57BL/6 mice); functionality of mp verified by collecting tissue samples to check for BrdU presence; cancer (local tumor response and lung metastasis); BrdU aka Bromodeoxyuridine; Nucleoside (synthetic analog of thymidine); Dose: 250 mg/mL BrdU in saline; Industry authored (Department of Radiation Life and Medical Science, Japan);.

15942 Miyazaki, Y., Shimizu, A., Ichikawa, I., Hosoya, T., Pastan, I., Matsusaka, T. Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury. Nephrol Dial Transplant 2014; 29(-5-):1005-12. >>> Uridine, bromodeoxy; saline; SC; mice; 2002, 2004; Controls received injection of saline; animal info: NEP25 mice; Dose: 1.25 ng/h/g body weight of BrdU; Industry authored (Nephrol Dial Transplant);.

15003 Lee, Y.H., Petkova, A.P., Konkar, A.A., Granneman, J.G., Granneman, J.G. Cellular origins of cold-induced brown adipocytes in adult mice. FASEB JOURNAL 2015; 29(--):286-299. >>> Norepinephrine; uridine, 5-bromo-2'-deoxyuridine; Ascorbic acid; Mice; Controls received mp w/ vehicle; animal info (C57BL6J or tdTomato);.

14995 Klaunig, J.E., Gehen, S.C., Wang, Z.M., Klein, P.J., Billington, R., Klaunig, J.E. Mechanism of 1,3-Dichloropropene-Induced Rat Liver Carcinogenesis. TOXICOLOGICAL SCIENCES 2015; 143(--):6-15. >>> Uridine, 5-bromo-2-deoxy-; Rat; Animal info (male, F344 rat, 6-4 weeks old);.

14980 Hunter, R.W., Ivy, J.R., Flatman, P.W., Kenyon, C.J., Craigie, E., Mullins, L.J., Bailey, M.A., Mullins, J.J., Hunter, R.W. Hypertrophy in the Distal Convoluted Tubule of an 11-Hydroxysteroid Dehydrogenase Type 2 Knockout Model. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1537-1548. >>> Uridine, bromodeoxy-; furosemide; DMSO; SC; Mice; 1007D; 2001; Animal info (WT or Hsd1 1b2 -/-); 50% DMSO used; pumps primed overnight in 37C saline;.

14899 Cruzan, G., Harkema, J.R., Hosako, H., Wasil, J.M., Murray, F.J., Cruzan, G. Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole. REGULATORY TOXICOLOGY AND PHARMACOLOGY 2015; 73(--):501-508. >>> Uridine, bromodeoxy; SC; Mice; Animal info (C57BL6 or CYP2F2, 8-11 weeks old);.

14882 Chen, H.J., Chen, C.H., Chang, M.Y., Tsai, D.C., Baum, E.Z., Hariri, R., Herzberg, U., Hsteh, P.C.H., Hsteh, P.C.H. Human Placenta-Derived Adherent Cells Improve Cardiac Performance in Mice With Chronic Heart Failure. STEM CELLS TRANSLATIONAL MEDICINE 2015; 4(--):269-275. >>> Uridine, bromodeoxy; SC; Mice; 1007D; Animal info (female, C57BL6, 25g); cardiovascular;.

14803 Reuter, S., Soonpaa, M.H., Firulli, A.B., Chang, A.N., Field, L.J., Field, L.J. Recombinant Neuregulin 1 Does Not Activate Cardiomyocyte DNA Synthesis in Normal or Infarcted Adult Mice. PLoS One 2014; 9(--):U1401-U1415. >>> Uridine, bromodeoxy-; Saline; Mice (transgenic); 1002; Animal info (MHC-nLAC tf, 12 weeks old); cardiovascular;.

14798 Rasoulpour, R.J., Andrus, A.K., Marty, M.S., Zhang, F., Thomas, J., LeBaron, M.J., Papineni, S., Pottenger, L.H., Eisenbrandt, D.L., Andrus, A.K. Pronamide: Human relevance of liver-mediated rat leydig cell tumors. REGULATORY TOXICOLOGY AND PHARMACOLOGY 2015; 72(--):394-404. >>> Uridine, bromo-2-deoxy-; PBS; SC; Rat; 2ML2; Animal info (male, Crl:CD(SC), 14-16 months old);“This implantation method insured a constant, uniform, systemic delivery of BrdU during the two week exposure period.” pg 396;.

14504 Yaqoob, N., Evans, A., Foster, J.R., Lock, E.A., Lock, E.A. Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure. Toxicology 2014; 323(--):70-77. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; Animal info (male, F-344, 13-14 weeks old, 236-312g); functionality of mp verified by BrdU imaging; toxicology;.

14494 Yamada, T., Okuda, Y., Kushida, M., Sumida, K., Takeuchi, H., Nagahori, H., Fukuda, T., Lake, B.G., Cohen, S.M., Kawamura, S., Yamada, T. Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver. TOXICOLOGICAL SCIENCES 2014; 142(--):137-157. >>> Growth hormone, recombinant human; uridine, bromodeoxy; SC; Mice(transgenic; SCID); rat; 1002; 2ML1; Animal info (mice male, CD-1 or ICR or SCID, 10 weeks old; rat male, Wistar, 10 weeks old); toxicology;.

14391 Schweikart, K.M., Eldridge, S.R., Safgren, S.L., Parman, T., Reid, J.M., Ames, M.M., Goetz, M.P., Davis, M.A., Schweikart, K.M. Comparative Uterotrophic Effects of Endoxifen and Tamoxifen in Ovariectomized Sprague-Dawley Rats. Toxicologic Pathology 2014; 42(--):1188-1196. >>> Uridine, bromodeoxy-; Sodium chloride; Rat; 2ML1; Animal info (female, Sprague Dawley, ovariectomized, 11-12 weeks old);.

14354 Pruthi, D., Khankin, E.V., Blanton, R.M., Aronovitz, M., Burke, S.D., McCurley, A., Karumanchi, S.A., Jaffe, I.Z., Jaffe, I.Z. Exposure to Experimental Preeclampsia in Mice Enhances the Vascular Response to Future Injury. Hypertension 2015; 65(--):863-+. >>> Uridine, bromodeoxy-; SC; Mice; Animal info (female, CD1, 2 months postpartum); cardiovascular; bp measured using tail cuff;.

14336 Owumi, S.E., Corthals, S.M., Uwaifo, A.O., Kamendulis, L.M., Klaunig, J.E., Owumi, S.E. Depletion of Kupffer Cells Modulates Ethanol-Induced Hepatocyte DNA Synthesis in C57BL/6 Mice. ENVIRONMENTAL TOXICOLOGY 2014; 29(--):867-875. >>> Uridine, bromodeoxy-; SC; Mice; Animal info (C57BL6, 27 weeks old); pumps primed;.

14306 Miyazaki, Y., Shimizu, A., Ichikawa, I., Hosoya, T., Pastan, I., Matsusaka, T., Miyazaki, Y. Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury. NEPHROLOGY DIALYSIS TRANSPLANTATION 2014; 29(--):1005-1012. >>> Uridine, bromodeoxy-; SC; Mice; 2002; 2004; Animal info (NEP25);.

14295 Masunaga, S.I., Sakurai, Y., Tano, K., Tanaka, H., Suzuki, M., Kondo, N., Narabayashi, M., Watanabe, T., Nakagawa, Y., Maruhashi, A., Ono, K., Masunaga, S.I. Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis. EXPERIMENTAL AND THERAPEUTIC MEDICINE 2014; 8(--):291-301. >>> Uridine, bromodeoxy-; Saline; SC; Mice; Animal info (female, C57Bl6, 8 weeks old); cancer (melanoma);.

14288 Mamidi, R.N.V.S., Proctor, J., De Jonghe, S., Feyen, B., Moesen, E., Vinken, P., Ma, J.Y., Bryant, S., Snook, S., Louden, C., Lammens, G., Ways, K., Kelley, M.F., Johnson, M.D., Johnson, M.D. Carbohydrate malabsorption mechanism for tumor formation in rats treated with the SGLT2 inhibitor canagliflozin. Chemico-Biological Interactions 2014; 221(--):109-118. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; Animal info (male, SPF Sprague Dawley, 8-9 weeks old); cancer (renal tubular tumors); diabetes;"The loaded minipumps were stored under aseptic conditions at approximately 30–37C (in an oven) to avoid crystallization.".

14259 LeBaron, M.J., Rasoulpour, R.J., Gollapudi, B.B., Sura, R., Kan, H.L., Schisler, M.R., Pottenger, L.H., Papineni, S., Eisenbrandt, D.L., LeBaron, M.J. Characterization of Nuclear Receptor-Mediated Murine Hepatocarcinogenesis of the Herbicide Pronamide and Its Human Relevance. TOXICOLOGICAL SCIENCES 2014; 142(--):74-92. >>> Uridine, bromodeoxy-; PBS; Mice; 2001; Animal info (male, CD-1, 8 weeks old); functionality of mp verified by staining; cancer (liver);.

14675 Braunger, B.M., Ademoglu, B., Koschade, S.E., Fuchshofer, R., Gabelt, B.T., Kiland, J.A., Hennes-Beann, E.A., Brunner, K.G., Kaufman, P.L., Tamm, E.R., Tamm, E.R. Identification of Adult Stem Cells in Schwalbe's Line Region of the Primate Eye. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2014; 55(--):7499-7507. >>> Uridine, bromodeoxy-; SC; Monkey (macaque); 2ML4; Animal info (Macaca fascicularis); pumps removed after 4 weeks;.

14669 Bless, E.P., Reddy, T., Acharya, K.D., Beltz, B.S., Tetel, M.J., Bless, E.P. Oestradiol and Diet Modulate Energy Homeostasis and Hypothalamic Neurogenesis in the Adult Female Mouse. Journal of Neuroendocrinology 2014; 26(--):805-816. >>> Uridine, bromodeoxy-; CSF, artificial; mouse serum albumin; CSF/CNS; Mice; 1007D; Animal info (famale, C57BL6J, 10-12 weeks old, bilateral overiectomy); pumps removed after 9 days;.

14576 Payton, M., Jun, T., Wayne, W., Yu, D., Manoukian, R., Chung, G., Zhang, N., Sun, J.R., Kaplan-Lefko, P., Scully, S., Van, G., Radinsky, R., Kendall, R., Oliner, J., Coxon, A., Payton, M. Antagonism of Ang-Tie2 and DII4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry method. LABORATORY INVESTIGATION 2014; 94(--):1296-1308. >>> Uridine, bromodeoxy; SC; Mice; 2001D; "BrdUrd was delivered for 18 h by implanted osmotic minipump, as a single-bolus injection of BrdUrd showed minimal BrdUrd uptake in TAECs compared with other more highly proliferative tissues..."pg 1299; labeling of tumor-associated endothelial cells (TAEC).

13869 Rock, M.L., Karas, A.Z., Rodriguez, K.B.G., Gallo, M.S., Pritchett-Corning, K., Karas, R.H., Aronovitz, M., Gaskill, B.N. The Time-to-Integrate-to-Nest Test as an Indicator of Wellbeing in Laboratory Mice. Journal of the American Association for Laboratory Animal Science 2014; 53(-1-):24-28. >>> Aldosterone; uridine, bromodeoxy-; Ethanol; saline; SC; Mice; Controls received mp w/ vehicle; animal info (10 mouse strains; BALB/cAnNCrl, 129S2/ SvPasCrl, FVB/NCrl, C57BL/6NCrl, C3H/HeNCrl, CB17/ Icr-Prkdcscid/IcrIcoCrl, NOD.CB17-Prkdcscid/NCrCrl, CB17.Cg/ Prkdcscid Lystbg/Crl, C57BL/6NTac, and C57BL/6NJ, carotid artery injury); 11% ethanol used; Multiple pumps per animal (2); post op. care (buprenorphine 0.05 mg/kg SC); behavioral testing (nesting behavoir); cardiovascular;.

13842 Landsiedel, R., Ma-Hock, L., Hofmann, T., Wiemann, M., Strauss, V., Treumann, S., Wohlleben, W., Groeters, S., Wiench, K., van Ravenzwaay, B., Landsiedel, R. Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials. Particle and Fibre Toxicology 2014; 11(--):U1-U26. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; Animal info (male, Wistar, Crl:WI, 7 weeks old); toxicology;.

13839 Krautz, C., Wolk, S., Steffen, A., Knoch, K.P., Ceglarek, U., Thiery, J., Bornstein, S., Saeger, H.D., Solimena, M., Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 2013; 56(-7-):1596-1604. >>> Uridine, bromodeoxy-; everolimus; tacrolimus; mycophenolate mofetil; sirolimus; DMSO; IP; Mice; 1004; Controls received mp w/ BrdU only; animal info (C57BL6, 10-12 weeks old, STZ); functionality of mp verified by blood levels; 100% DMSO used; stress/adverse reaction: (see pg.1598); toxicology; diabetes;.

13742 Christie, K.J., Turbic, A., Turnley, A.M. ADULT HIPPOCAMPAL NEUROGENESIS, RHO KINASE INHIBITION AND ENHANCEMENT OF NEURONAL SURVIVAL. Neuroscience 2013; 247(-;-):75-83. >>> Uridine, 5-ethynyl-2'-deoxy; Y27632; CSF/CNS; Mice; 1007D; Animal info (male, C57BL6, 8-9 weeks old); ALZET brain infusion kit used; behavioral testing (elevated plus maze; object recognition; y maze); ethynyldeoxyuridine aka EDU; Y27632 is a ROCK inhibitor;.

13659 Robins, S.C., Villemain, A., Liu, X.H., Djogo, T., Kryzskaya, D., Storch, K.F., Kokoeva, M.V. Extensive regenerative plasticity among adult NG2-glia populations is exclusively based on self-renewal. Glia 2013; 61(-10-):1735-1747. >>> Uridine, bromodioxy; Ara-C; Cerebrospinal fluid, artificial; CSF/CNS; Mice (transgenic); Animal info (male, NG2-CreER:tomato, 8-12 weeks old); pulsatile delivery (delayed delivery 2 days with vehicle in catheter); brain tissue distribution; cyanoacrylate adhesive used to close catheter tubing; Plastics 1 cannula and catheter.

13605 Lindau, N.T., Baenninger, B.J., Gullo, M., Good, N.A., Bachmann, L.C., Starkey, M.L., Schwab, M.E. Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy. Brain 2014; 137(-;-):739-756. >>> Antibody, mouse monocolonal anti-Nogo-A 11C7; uridine, anti-bromodeoxy; CSF/CNS (intrathecal); Rat; 2ML2; Controls received mp w/control antibody; animal info (female, Long Evans, 3-7 months, 230-400g); ischemia (photothrombic); post op. care (Rimadyl 2.5mg/kg, Baytril 5mg/kg for 3 days; mannitol 20% injection 17 mg/kg; heating pad for 24h); behavioral testing (pellet grasping); pump and catheter removed after 2 weeks; used 32 gauge intrathecal catheter;.

13546 Morimoto, Y., Oyabu, T., Horie, M., Kambara, T., Izumi, H., Kuroda, E., Creutzenberg, O., Bellmann, B., Pohlmann, G., Schuchardt, S., Hansen, T., Ernst, H. Pulmonary toxicity of printer toner following inhalation and intratracheal instillation. INHALATION TOXICOLOGY 2013; 25(-12-):679-690Uridine, bromodeoxy;. >>> Uridine, bromodeoxy;; Rat; 2ML1; Animal info (Female, Wistar, 8 weeks old); functionality of mp verified by BrdU imaging; toxicology; immunology; pumps used to deliver BrdU for imaging purposes only.

13533 Khuu, D.N., Nyabi, O., Maerckx, C., Sokal, E., Najimi, M. Adult Human Liver Mesenchymal Stem/Progenitor Cells Participate in Mouse Liver Regeneration After Hepatectomy. CELL TRANSPLANTATION 2013; 22(-8-):1369-1380. >>> Uridine, bromodeoxy;; IP; Mice (SCID); .

13218 Gouaze, A., Brenachot, X., Rigault, C., Krezymon, A., Rauch, C., Nedelec, E., Lemoine, A., Gascuel, J., Bauer, S., Penicaud, L., Benani, A. Cerebral Cell Renewal in Adult Mice Controls the Onset of Obesity. PLoS One 2013; 8(-8-):U971-U981. >>> Uridine, bromodeoxy-;; NaCl; SC; Mice; 1007D; Brain infusion kit (3) used; antisense (Arac); 65 mm tubing connected to mp allowed for delayed delivery of vehicle for 2 days after surgery; animal info. (seven week-old male, C57BL/6);.

13157 Douvaras, P., Mort, R.L., Edwards, D., Ramaesh, K., Dhillon, B., Morley, S.D., Hill, R.E., West, J.D. Increased Corneal Epithelial Turnover Contributes to Abnormal Homeostasis in the Pax6(+/-) Mouse Model of Aniridia. PLoS One 2013; 8(-8-):U372-U389. >>> Uridine, bromodeoxy; SC; Mice; 1007D; Animal info (15 or 30 wks old); label of the adult cornea.

13063 Robins, S.C., Trudel, E., Rotondi, O., Liu, X.H., Djogo, T., Kryzskaya, D., Bourque, C.W., Kokoeva, M.V. Evidence for NG2-glia Derived, Adult-Born Functional Neurons in the Hypothalamus. PLoS One 2013; 8(-10-):U880-U890. >>> Uridine, bromodeoxy; uridine, ethynyldeoxy; CSF, artificial; CSF/CNS; Mice; Animal info (NG2-CreER:tdTomato); Plastics One cannula used; labeling of NG2 derived neurons.

12986 Yu, Z., Ricciotti, E., Miwa, T., Liu, S.L., Ihida-Stansbury, K., Landersberg, G., Jones, P.L., Scalia, R., Song, W.C., Assoian, R.K., FitzGerald, G.A. Myeloid Cell 5-Lipoxygenase Activating Protein Modulates the Response to Vascular Injury. Circulation Research 2013; 112(-3-):432-U71. >>> Uridine, bromodeoxy; SC; Mice; Animal info (C57BL/6, FLAP KO, male, 12 wks old).

12898 Isobe, K., Ito, T., Komatsu, S., Asanuma, K., Fujii, E., Kato, C., Adachi, K., Kato, A., Sugimoto, T., Suzuki, M. Stimulation of Adrenal Chromaffin Cell Proliferation by Hypercalcemia Induced by Intravenous Infusion of Calcium Gluconate in Rats. Journal of Toxicologic Pathology 2012; 25(-4-):281-285. >>> Uridine, bromodeoxy; IP; Rat; Animal info (Sprague Dawley, male, 8 wks old); labeling of chromaffin cells in the adrenal glands.

12842 Masunaga, S., Sakurai, Y., Tanaka, H., Hirayama, R., Matsumoto, Y., Uzawa, A., Suzuki, M., Kondo, N., Narabayashi, M., Maruhashi, A., Ono, K. Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction. British Journal of Radiology 2013; 86(-1021-):U173-U182. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; Animal info (C57BL/6, female, syngenic, 9 wks old).

12829 Masunaga, S., Sakurai, Y., Tanaka, H., Suzuki, M., Kondo, N., Narabayashi, M., Maruhashi, A., Ono, K. Wortmannin efficiently suppresses the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population. Journal of Radiation Research 2013; 54(-2-):221-229. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; Animal info (C57BL/6J , female, 9 wks old, syngenic).

12803 Mishima, K., Maeshima, A., Miya, M., Sakurai, N., Ikeuchi, H., Hiromura, K., Nojima, Y. Involvement of N-type Ca(2+) channels in the fibrotic process of the kidney in rats. American Journal of Physiology-Renal Physiology 2013; 304(-6-):F665-F673. >>> Uridine, bromodeoxy; IP; Rat; Animal info (Wistar, male, 200 g); labeling of label-retaining cells (LRCs).

12731 Wang, X.Y., Keefe, K.M., Jensen-Taubman, S.M., Yang, D.L., Yan, K., Linnoila, R.I. Novel Method for Isolation of Murine Clara Cell Secretory Protein-Expressing Cells with Traces of Stemness. PLoS One 2012; 7(-8-):U218-U227. >>> Uridine, bromodeoxy; SC; Mice; 2001; Animal info (FVB, 2 mo old).

12668 Zachrisson, O., Zhao, M., Andersson, A., Dannaeus, K., Haeggblad, J.H., Isacson, R., Nielsen, E., Patrone, C., Roennholm, H., Wikstrom, L., Delfani, K., McCormack, A.L., Palmer, T., Di Monte, D.A., Hill, M.P., Lang, A.M.J., Haegerstrand, A. Restorative Effects of Platelet Derived Growth Factor-BB in Rodent Models of Parkinson's Disease. JOURNAL OF PARKINSONS DISEASE 2011; 1(-1-):49-63. >>> Ara-C; platelet-derived growth factor; uridine, bromodeoxy; CSF/CNS; Mice; rat; 2002; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 280-350 g, C57BL/6, 10 wks old); neurodegenerative (Parkinson's disease).

12646 Bermudez, E., Willson, G., Parkinson, H., Dodd, D. Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar Rats for 13?weeks or one year via drinking water. Journal of Applied Toxicology 2012; 32(-9-):687-706. >>> Uridine, bromodeoxy; PBS; SC; Rat; 2ML1; Animal info (Wistar, male, female, 4-6 wks old).

12526 Kadar, T., Horwitz, V., Sahar, R., Cohen, M., Cohen, L., Gez, R., Tveria, L., Gutman, H., Buch, H., Fishbine, E., Brandeis, R., Dachir, S., Amir, A. Delayed Loss of Corneal Epithelial Stem Cells in a Chemical Injury Model Associated with Limbal Stem Cell Deficiency in Rabbits. Current Eye Research 2011; 36(-12-):1098-1107. >>> Uridine, bromodeoxy; DMSO; water; SC; Rabbit; Animal info (New Zealand, White, female, 2-3 kg); labeling of slow cycling cells.

12458 Criswell, K.A., Cook, J.C., Morse, D., Lawton, M., Somps, C., Obert, L., Roy, M., Sokolowski, S., Koza-Taylor, P., Colangelo, J., Navetta, K., Brady, J., Pegg, D., Wojcinski, Z., Rahbari, R., Duddy, S., Anderson, T. Pregabalin Induces Hepatic Hypoxia and Increases EndothelialCell Proliferation in Mice, a Process Inhibited by DietaryVitamin E Supplementation. TOXICOLOGICAL SCIENCES 2012; 128(-1-):42-56. >>> Uridine, bromodeoxy; uridine, 5-ethynyl-2'-deoxy; Sodium carbonate; saline; SC; Mice; rat; 2001; 2ML1; Animal info (B6C3F1, 9-11 wks old, 18.5-22 g, Wistar, 6-8 wks old, 151-250 g); labeling of endothelial cells.

12454 Germann, M., Wetterwald, A., Guzman-Ramirez, N., van der Pluijm, G., Culig, Z., Cecchini, M.G., Williams, E.D., Thalmann, G.N. Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer. Stem Cells 2012; 30(-6-):1076-1086. >>> Uridine, bromodeoxy; NaCl; SC; Mice (SCID); Animal info (male, SCID); 14-day pump used; labeling of CR BM18 cancer cells; cancer (prostate).

12306 Adams, A.C., Coskun, T., Rovira, A.R.I., Schneider, M.A., Raches, D.W., Micanovic, R., Bina, H.A., Dunbar, J.D., Kharitonenkov, A. Fundamentals of FGF19&FGF21 Action In Vitro and In Vivo. PLoS One 2012; 7(-5-):U1479-U1489. >>> Fibroblast growth factor 19; fibroblast growth factor 21; uridine, bromodeoxy; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL/6J, ob/ob, 9 wks old); labeling of hepatocytes.

12144 Futamura, M., Yao, J., Li, X., Bergeron, R., Tran, J.L., Zycband, E., Woods, J., Zhu, Y., Shao, Q., Maruki-Uchida, H., Goto-Shimazaki, H., Langdon, R.B., Erion, M.D., Eiki, J., Zhou, Y.P. Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat. Diabetologia 2012; 55(-4-):1071-1080. >>> Uridine, bromodeoxy; SC; Rat; 2ML1; animal info (5 wks old, Zucker); labeling of beta cells.

12140 Oikonomopoulos, A., Sereti, K.I., Conyers, F., Bauer, M., Liao, A., Guan, J., Crapps, D., Han, J.K., Dong, H.H., Bayomy, A.F., Fine, G.C., Westerman, K., Biechele, T.L., Moon, R.T., Force, T., Liao, R.L. Wnt Signaling Exerts an Antiproliferative Effect on Adult Cardiac Progenitor Cells Through IGFBP3. Circulation Research 2011; 109(-12-):1363-1374. >>> Uridine, bromodeoxy; Mice; Animal info (male, female, C57BL/6J, 8-12 wks old); labeling of cardiac side population cells.

12110 Cruzan, G., Bus, J., Hotchkiss, J., Harkema, J., Banton, M., Sarang, S. CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors. Regulatory Toxicology and Pharmacology 2012; 62(-1-):214-220. >>> Uridine, 5-bromo 2'-deoxy; Saline; SC; Mice; 2001; Animal info (CYP2F2 -/-, male); labeling of S-phase cells.

12013 Speit, G., Schuetz, P., Weber, I., Ma-Hock, L., Kaufmann, W., Gelbke, H.P., Durrer, S. Analysis of micronuclei, histopathological changes and cell proliferation in nasal epithelium cells of rats after exposure to formaldehyde by inhalation. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2011; 721(-2-):127-135. >>> Uridine, 5-bromo 2'-deoxy; SC; Rat; 2ML1; Animal info (male, Fischer 344).

11997 Loffredo, F.S., Steinhauser, M.L., Gannon, J., Lee, R.T. Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair. Cell Stem Cell 2011; 8(-4-):389-398. >>> Uridine, bromodeoxy; SC; Mice (transgenic); Animal info (double Tg MerCreMer-Zeg); labeling of cardiomyocytes.

11917 Li, Q.H., Guo, Y., Ou, Q.H., Chen, N., Wu, W.J., Yuan, F.P., O'Brien, E., Wang, T., Luo, L., Hunt, G.N., Zhu, X.P., Bolli, R. Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models. Basic Research In Cardiology 2011; 106(-5-):849-864. >>> Uridine, bromodeoxy; Mice; Animal info (female, C57BL/6); labeling of cardiac stem cells (CSC's).

11900 McNay, D.E.G., Briancon, N., Kokoeva, M.V., Maratos-Flier, E., Flier, J.S. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. Journal of Clinical Investigation 2012; 122(-1-):142-152. >>> Leptin; uridine, bromodeoxy; CSF, artificial; albumin, mouse serum; CSF/CNS; Mice; 1007D; animal info (C57BL/6, DIO, male, 8 wks old); Plastics One guide cannula used.

11828 Suzuki, M., Isobe, K., Fujii, E., Yamazaki, M., Takai, Y., Soshin, T., Akai, S., Watanabe, T., Kato, A. Cell proliferative activity in the kidney of young growing rat analyzed using flash and cumulative labeling with bromodeoxyuridine. JOURNAL OF TOXICOLOGICAL SCIENCES 2010; 35(-5-):631-637. >>> Uridine, bromodeoxy; DMSO; water, distilled; IP; Rat; 2002; Animal info (Sprague Dawley, female); 50% DMSO used; multiple pumps (2) used; pumps replaced after 2 weeks; no stress"No abnormal clinical signs were observed in any animal"pg 633; labeling of kidney cells.

11721 Hirabayashi, Y., Inoue, T. Benzene-induced bone-marrow toxicity: A hematopoietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect. Chemico-Biological Interactions 2010; 184(-1-2-):252-258. >>> Uridine, bromodeoxy; Mice; Animal info (AhR-KO); labeling of hematopoietic progenitor cells.

11703 Ford, J., Hajibeigi, A., Long, M., Hahner, L., Gore, C., Hsieh, J.T., Clegg, D., Zerwekh, J., Oez, O.K. GPR30 Deficiency Causes Increased Bone Mass, Mineralization, and Growth Plate Proliferative Activity in Male Mice. Journal of Bone and Mineral Research 2011; 26(-2-):298-307. >>> Uridine, bromodeoxy; IP; Mice; 1003D; Animal info (C57Bl6/J x 129SvEvTac, GPR30 null).

11577 Sakaguchi, M., Imaizumi, Y., Shingo, T., Tada, H., Hayama, K., Yamada, O., Morishita, T., Kadoya, T., Uchiyama, N., Shimazaki, T., Kuno, A., Poirier, F., Hirabayashi, J., Sawamoto, K., Okano, H. Regulation of adult neural progenitor cells by Galectin-1/beta 1 Integrin interaction. Journal of Neurochemistry 2010; 113(-6-):1516-1524. >>> Antibody, monoclonal anti-beta 1, integrin neutralizing; galectin-1; antibody, anti-galectin-1; uridine, bromodeoxy; Saline; albumin, mouse serum; CSF/CNS; Mice; Controls received mp w/ hamster control antibody; animal info (adult, 8 wks old).

11499 Masunaga, S., Hirayama, R., Uzawa, A., Kashino, G., Takata, T., Tanaka, H., Suzuki, M., Kinashi, Y., Liu, Y., Koike, S., Ando, K., Ono, K. Influence of manipulating hypoxia in solid tumors on the radiation dose-rate effect in vivo, with reference to that in the quiescent cell population. Japanese Journal of Radiology 2010; 28(-2-):132-142. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; Animal info (C3H/He, 9 wks old, syngenic, female).

11468 Lee, C., Agoston, D.V. Vascular Endothelial Growth Factor Is Involved in Mediating Increased De Novo Hippocampal Neurogenesis in Response to Traumatic Brain Injury. Journal of Neurotrauma 2010; 27(-3-):541-553. >>> Vascular endothelial growth factor 164; SU5416; uridine, bromodeoxy; CSF, artificial; DMSO; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (young, Sprague Dawley, male, 270-300 g); 1% DMSO used.

11457 Kumar, S., Matheny, C.J., Hoffman, S.J., Marquis, R.W., Schultz, M., Liang, X.G., Vasko, J.A., Stroup, G.B., Vaden, V.R., Haley, H., Fox, J., DelMar, E.G., Nemeth, E.F., Lago, A.M., Callahan, J.F., Bhatnagar, P., Huffman, W.F., Gowen, M., Yi, B.M., Danoff, T.M., Fitzpatrick, L.A. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation. Bone 2010; 46(-2-):534-542. >>> Uridine, 5-bromodeoxy-2'-; SC; Rat; Animal info (6 mo old, Sprague Dawley, female).

11405 Imanishi, Y., Kawata, T., Kenko, T., Wada, M., Nagano, N., Miki, T., Arnold, A., Inaba, M. Cinacalcet HCl Suppresses Cyclin D1 Oncogene-Derived Parathyroid Cell Proliferation in a Murine Model for Primary Hyperparathyroidism. Calcified Tissue International 2011; 89(-1-):29-35. >>> Uridine, bromodeoxy-; SC; Mice; 2001; Animal info (PC2, wt, 7-84 wks old).

11359 Glinghammar, B., Berg, A.L., Bjurstroem, S., Stockling, K., Blomgren, B., Westerberg, R., Skaanberg, I., Hellmold, H., Andersson, U. Proliferative and Molecular Effects of the Dual PPAR alpha/gamma Agonist Tesaglitazar in Rat Adipose Tissues: Relevance for Induction of Fibrosarcoma. Toxicologic Pathology 2011; 39(-2-):325-336. >>> Uridine, bromodeoxy; SC; Rat; Animal info (male, Wistar, Hannover, Galas).

11254 Boverhof, D.R., Chamberlain, M.P., Elcombe, C.R., Gonzalez, F.J., Heflich, R.H., Hernandez, L.G., Jacobs, A.C., Jacobson-Kram, D., Luijten, M., Maggi, A., Manjanatha, M.G., van Benthem, J., Gollapudi, B.B. Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook. TOXICOLOGICAL SCIENCES 2011; 121(-2-):207-233. >>> Uridine, bromodeoxy; SC; Mice; 2001; Animal info (male, sexually mature, huPXR/huCAR, PXRKO/CARKO, wt).

11230 Angert, D., Berretta, R.M., Kubo, H., Zhang, H.Y., Chen, X.W., Wang, W., Ogorek, B., Barbe, M., Houser, S.R. Repair of the Injured Adult Heart Involves New Myocytes Potentially Derived From Resident Cardiac Stem Cells. Circulation Research 2011; 108(-10-):1226-U230. >>> Isoproterenol; uridine, bromodeoxy; DMSO; water, deionized; SC; Cat; 2ML1; Animal info (adulit, feline, 5-6 mo old); post op. care (Bupivicane); 50% DMSO used.

11148 Yoshida, Y., Fukuda, N., Maeshima, A., Yamamoto, C., Matsumoto, T., Ueno, T., Nojima, Y., Matsumoto, K., Soma, M. Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats. Journal of Hypertension 2011; 29(-1-):91-101. >>> Angiotensin II; uridine, bromodeoxy; SC; IP; Rat; Animal info (Wistar Kyoto); peptides; systolic blood pressure was measured by tail-cuff (BO-98A; Softron Co).

11117 Wang, M.A., Ihida-Stansbury, K., Kothapalli, D., Tamby, M.C., Yu, Z., Chen, L.H., Grant, G., Cheng, Y., Lawson, J.A., Assoian, R.K., Jones, P.L., FitzGerald, G.A. Microsomal Prostaglandin E(2) Synthase-1 Modulates the Response to Vascular Injury. Circulation 2011; 126(-6-):631-U181. >>> Uridine, bromodeoxy; SC; Mice; 2002; Animal info (mPGES-1 KO, wt).

11111 Masunaga, S.I., Tano, K., Nakamura, J., Watanabe, M., Kashino, G., Suzuki, M., Kinashi, Y., Ono, K. Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine compared to its effect combined with tirapazamine in the treatment of solid tumors. EXPERIMENTAL AND THERAPEUTIC MEDICINE 2010; 1(-1-):169-174. >>> Uridine, 2-bromodeoxy 5-; tirapazamine; hexamethylenetetramine; Saline, physiological; SC; IP; Mice; Animal info (syngeneic female C3H/He, 8-11 wks old); comparison of IP injections vs mp; cancer;"Continuous administration of HMTA and TPZ resulted in higher radio- and cisplatin-sensitizing effects than intraperitoneal single administration."pg 169.

11092 Masunaga, S., Matsumoto, Y., Kashino, G., Hirayama, R., Liu, Y., Tanaka, H., Sakurai, Y., Suzuki, M., Kinashi, Y., Maruhashi, A., Ono, K. Significance of manipulating tumour hypoxia and radiation dose rate in terms of local tumour response and lung metastatic potential, referring to the response of quiescent cell populations. British Journal of Radiology 2010; 83(-993-):776-784. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; Animal info (8 wks old, syngenic, female, C57BL/6).

11042 Verdeguer, F., Le Corre, S., Fischer, E., Callens, C., Garbay, S., Doyen, A., Igarashi, P., Terzi, F., Pontoglio, M. A mitotic transcriptional switch in polycystic kidney disease. Nature Medicine 2010; 16(-1-):106-U143. >>> Uridine, bromodeoxy; Mice; Animal info (Hnf1bflox/flox, wt).

10929 Guo, N., Parry, E.M., Li, L.S., Kembou, F., Lauder, N., Hussain, M.A., Berggren, P.O., Armanios, M. Short Telomeres Compromise beta-Cell Signaling and Survival. PLoS One 2011; 6(-3-):U429-U438. >>> Uridine, 5-ethynyl-2-deoxy; SC; Mice; Animal info (mTR +/-); 5-ethynyl-2-deoxyuridine also known as EdU.

10907 Schupp, N., Kolkhof, P., Queisser, N., Gaertner, S., Schmid, U., Kretschmer, A., Hartmann, E., Oli, R.G., Schaefer, S., Stopper, H. Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats. FASEB Journal 2011; 25(-3-):968-978. >>> Uridine, bromodeoxy; Rat; Animal info (male, Crl:CD, Sprague-Dawley); 2ml pump used.

10894 Leong, S.Y., Faux, C.H., Turbic, A., Dixon, K.J., Turnley, A.M. The Rho Kinase Pathway Regulates Mouse Adult Neural Precursor Cell Migration. Stem Cells 2011; 29(-2-):332-343. >>> Uridine, bromodeoxy; Y27632; CSF/CNS; Mice; 1007D; Controls received mp w/ BrdU only; animal info (6-8 wks old, male, C57BL/6).

10596 Cunningham, M.L., Collins, B.J., Hejtmancik, M.R., Herbert, R.A., Travlos, G.S., Vallant, M.K., Stout, M.D. Effects of the PPAR-alpha Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism. PPAR Research 2010; ;(-;-):U1-U14. >>> Uridine, bromodeoxy; Sodium hydroxide; SC; Rat; mice; hamster; 2001; Labeling of hepatocytes.

10586 Andersen, M.E., Clewell, HJ III, Bermudez, E., Dodd, D.E., Willson, G.A., Campbell, J.L., Thomas, R.S. Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound. TOXICOLOGICAL SCIENCES 2010; 118(-2-):716-731. >>> Uridine, bromodeoxy; Rat; 2ML1; Animal info (male, (F344)/CrlBR, 6-7 wks old); labelling of the duodenum.

10554 Elcombe, C.R., Elcombe, B.M., Foster, J.R., Farrar, D.G., Jung, R., Chang, S.C., Kennedy, G.L., Butenhoff, J.L. Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR-alpha; and CAR/PXR. Archives of Toxicology 2010; 84(-10-):787-798. >>> Uridine, bromodeoxy; PBS; Rat; 2ML1; Animal info (male, 7-8 wks old Sprague Dawley); labeling of hepatic S-phase.

10454 Masunaga, S., Tano, K., Nakamura, J., Watanabe, M., Kashino, G., Takahashi, A., Tanaka, H., Suzuki, M., Ohnishi, K., Kinashi, Y., Liu, Y., Ohnishi, T., Ono, K. Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status. Journal of Radiation Research 2010; 51(-1-):27-35. >>> Uridine, bromodeoxy; hexamethylenetetramine; Saline, physiological; SC; Mice (nude); 2001D; 2001; Cancer; toxicology; animal info (6-7 weeks old, female, syngenic, Balb/Ca).

10444 Wu, X.L., Ge, H.F., Lemon, B., Vonderfecht, S., Weiszmann, J., Hecht, R., Gupte, J., Hager, T., Wang, Z.L., Lindberg, R., Li, Y. FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation. Journal of Biological Chemistry 2010; 285(-8-):5165-5170. >>> Uridine, 5-bromo-2'-deoxy-; SC; Mice; 1007D; Animal info (female, FVB, 8 weeks old).

10428 Pierce, A.A., Xu, A.W. De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance. Journal of Neuroscience 2010; 30(-2-):723-730. >>> Ara-C; uridine, 5'bromodeoxy; CSF, artificial; BSA; CSF/CNS; Mice (transgenic); 2006; Controls received mp w/ vehicle; ALZET brain infusion kit; animal info (male, wt, AgRP-Tfam, 12 weeks old); functionality of mp verified by residual volume; cannula placement confirmed histologically.

10389 Oki, K., Kaneko, N., Kanki, H., Imai, T., Suzuki, N., Sawamoto, K., Okano, H. Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia. NEUROSCIENCE RESEARCH 2010; 66(-4-):390-395. >>> Uridine, bromodeoxy; SC; Mice; 1003D; Animal info (adult, 8-9 weeks old, B6, 23-27 g); labeling of MSI-1 positive cells; MCAO.


Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!


Order the ALZET SurgicalImplantation Video

What researchers are saying...

“In order to investigate the in vivo role of MMPs, we established a rodent model of glioma progression... We chose continuous infusion using an osmotic pump as the method for delivering TIMP into the tumor. This paradigm allowed aggressive glioma development and circumvented the problem of the blood brain barrier disturbing reagent delivery following intravenous delivery.” Takahashi et al., Pharmacological Research 2002;46(2):155-163.