References on Cancer Research Using ALZET® Osmotic Pumps

16349 Muller, F, Stookey, S, Cunningham, T, Pastan, I. Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies. ONCOTARGET 2017; (--):1-12. >>> HA22- PE24 recombinant immunotoxin; Citrate buffer; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (6-8-week-old NSG mice); JeKo-1 xenograft model; Citrate buffer: 32 mM citrate, 0.65% Tween80, 5 mM EDTA; comparison of 3 times IV bolus injections vs mp; cancer (Mantle Cell Lymphoma); half-life: 15 minutes in mice (p. 4); To enable continuous drug delivery in vivo, the rIT-formulation buffer was optimized to ensure protein stability. Stability for 7-days with citrate buffer verified using WST-8 cell proliferation assay;“Continuous infusion substantially increased efficacy of LR compared to bolus dose administration.” pg 4; “a well-tolerated total amount of 84Ǩg LR given by continuous infusion is substantially more active than the 120Ǩg LR given as three bolus doses QOD.” (P. 5); Because rITs have a short plasma half-life in mice and men, blood levels fall quickly after a bolus dose; Dose (1 mg/ml); Immunotoxin plasma concentration was on average 45 ng/ml, correlating with an AUC of 350 ng x day/mlPlasma. This steady state plasma concentration was higher than theIC50 of any of the MCL cell lines tested..

16336 Feldman, R. D., Ding, Q., Hussain, Y., Limbird, L. E., Pickering, J. G., Gros, R. Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER). FASEB J 2016; 30(-6-):2086-96. >>> Aldosterone; G protein-coupled estrogen receptor 15 antagonist; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (BALB/c male mice, 2 month old); cancer (Orthotopic renal cancer); dose-response (pg. 2093); Dose (200 ug/kg/day for both);.

16333 Eskiocak, U., Ramesh, V., Gill, J. G., Zhao, Z., Yuan, S. W., Wang, M., Vandergriff, T., Shackleton, M., Quintana, E., Johnson, T. M., DeBerardinis, R. J., Morrison, S. J. Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nat Commun 2016; 7(--):12336. >>> Digoxin; Promethylcellulose, Tween80, DMSO; SC; mice; Controls received mp w/ vehicle; animal info (NSG mice); 0.5% used Promethylcellulose, 0.2% Tween80 used, 5% DMSO; cancer (xenograft models); dose-response (pg. 14); Dose (10 mg/kg/day);.

16310 Futamura, G., Kawabata, S., Nonoguchi, N., Hiramatsu, R., Toho, T., Tanaka, H., Masunaga, S. I., Hattori, Y., Kirihata, M., Ono, K., Kuroiwa, T., Miyatake, S. I. Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma. Radiat Oncol 2017; 12(-1-):26. >>> ACBC-BSH (Boron-10 derivative); CSF/CNS; Rat; 2001D; ALZET brain infusion kit used; comparison of IV injections vs mp; cancer (F98 glioma); brain tissue distribution;“we succeeded in achieving a high accumulation of boron in the tumors of rats in which ACBC-BSH was administered by CED, compared with ACBC-BSH administered intravenously” pg. 9 ; ACBC-BSH is a boron-10 containing sodium borocaptate derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid; Dose(1.2 mg/kg);.

16303 Beauvais, D. M., Jung, O., Yang, Y., Sanderson, R. D., Rapraeger, A. C. Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Cancer Res 2016; 76(-17-):4981-93. >>> Synstatin(IGF1R), Synstatin(IGF1R-T); PBS; SC; Mice (NUDE); 2004; Controls received mp w/ vehicle; animal info (6- to 8-week-old female, athymic Foxn1nu outbred nude mice); functionality of mp verified by tumor volume measurements; cancer (Multiple Myeloma); dose-response (pg. 4989-4990); Xenograft model; Dose (3.6 mg/kg/d); Resultant plasma level (30 umol/L); Interesting (Evidence of tumor elimination);.

16300 Bigley, A. L., Klein, S. K., Davies, B., Williams, L., Rudmann, D. G. Using Automated Image Analysis Algorithms to Distinguish Normal, Aberrant, and Degenerate Mitotic Figures Induced by Eg5 Inhibition. Toxicol Pathol 2016; 44(-5-):663-72. >>> Eg5 inhibitor; DMSO, captisol; SC; Rat (Nude); Controls received mp w/ vehicle; animal info (human transitional cell carcinoma (TCC) cell line MGHU3 in nude rats); 50% DMSO, 60% captisol used; cancer (bladder); dose-response (pg 667-669); enzyme inhibitor (kinesin-5 inhibitor); human transitional cell carcinoma (TCC) cell line MGHU3; xenograft model; Dose (1.375 mg/kg/d, 2.75 mg/kg/d, 4.6 mg/kg/d);.

16299 Borcherding, D. C., Tong, W., Hugo, E. R., Barnard, D. F., Fox, S., LaSance, K., Shaughnessy, E., Ben-Jonathan, N. Expression and therapeutic targeting of dopamine receptor-1 (D1R) in breast cancer. Oncogene 2016; 35(-24-):3103-13. >>> Fenoldopam; PBS; SC; mice; 1004; Controls received mp w/ vehicle; animal info (Eight-week-old female athymic nu/nu mice; inoculated with MDA-MB-231 cells or SUM159 cells); functionality of mp verified by measurement of tumor volumes; cancer (breast cancer); dose-response (pg. 3109); Xenograft models; Dose (400 ng/kg/min or 133 ng/kg/min);.

16295 Cadamuro, M., Spagnuolo, G., Sambado, L., Indraccolo, S., Nardo, G., Rosato, A., Brivio, S., Caslini, C., Stecca, T., Massani, M., Bassi, N., Novelli, E., Spirli, C., Fabris, L., Strazzabosco, M. Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cancer Res 2016; 76(-16-):4775-84. >>> Paclitaxel; Cremophor EL, Ethanol; IP; Mice (SCID); 1004; Controls received mp w/ vehicle; animal info (SCID mice 6–8 weeks old); functionality of mp verified by bioluminescence imaging to check metastatic spread; 50% Cremophor, 50% ethanol used; cancer (Cholangiocarcinoma); Xenograft model; Dose (2.6 mg/kg/d);.

16265 Tso, J. L., Yang, S., Menjivar, J. C., Yamada, K., Zhang, Y., Hong, I., Bui, Y., Stream, A., McBride, W. H., Liau, L. M., Nelson, S. F., Cloughesy, T. F., Yong, W. H., Lai, A., Tso, C. L. Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. Mol Cancer 2015; 14(--):189. >>> Bone morphogenic protein-7, Temozolomide; Water; DMSO; CSF/CNS; mice; 1007D; Controls received mp w/ vehicle; animal info (NOD (CB17-Prkdcscid/J) mice (5 weeks old; 15–16 g)); functionality of mp verified by observation of neurological signs; 0.01% DMSO used; cancer (intracranial tumor); Dose (100Ǩl of 35ǨM TMZ, 10 ng BPM7).

16225 Parrish, K. E., Cen, L., Murray, J., Calligaris, D., Kizilbash, S., Mittapalli, R. K., Carlson, B. L., Schroeder, M. A., Sludden, J., Boddy, A. V., Agar, N. Y., Curtin, N. J., Elmquist, W. F., Sarkaria, J. N. Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System. Mol Cancer Ther 2015; 14(-12-):2735-43. >>> rucaparib; DMSO; IP; mice; 1003D; animal info (triple knockout (TKO: Mdr1a/1b-/-;Bcrp1-/-) mice); functionality of mp verified by Steady-state concentrations in brain and plasma; cancer (glioblastoma); brain tissue distribution; Resultant brain and plasma level (pg 2738); Dose (5 ug/hour);.

16224 Parrish, K. E., Pokorny, J., Mittapalli, R. K., Bakken, K., Sarkaria, J. N., Elmquist, W. F. Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model. J Pharmacol Exp Ther 2015; 355(-2-):264-71. >>> Palbociclib; DMSO, saline; IP; Mice; 1003D; Controls received mp w/ vehicle; animal info (wild-type, Mdr1a/b2/2, Bcrp12/2, and Mdr1a/b2/2Bcrp12/2 mice); functionality of mp verified by brain and plasma level; cancer (brain tumor); good methods (pg 265); Wound clips used; Resultant brain-to-plasma ratios (pg 268); Dose (10 mg/ml);.

16213 Mohammad-Djafari, Ali, Dumitru, Mircea  Digital Signal Processing 2015; 47(--):128-156. >>> D-luciferin; SC; mice; animal info (KI/KI Per2::luc mouse, aged 10 weeks); functionality of mp verified by measurement of locomotor activity; cancer; Circadian period; circadian rhythm; Dose (90mg/ml);.

16207 Mao, A. W., Jiang, T. H., Sun, X. J., Peng, J. Application of chemokine receptor antagonist with stents reduces local inflammation and suppresses cancer growth. Tumour Biol 2015; 36(-11-):8637-43. >>> AMD3100; PBS; SC; Mice (NOD/SCID); Controls received mp w/ saline; animal info (NOD/SCID); cancer (pancreatic); dose-response (pg 8640); enzyme inhibitor (SDF-1); AMD3100 is a specific inhibitor binding of SDF-1 and its receptor C-X-C chemokine receptor 4 (CXCR4); 3 % isoflurane used; dose: 2 mg.

16202 Liu, Y., Li, B., Wang, X., Li, G., Shang, R., Yang, J., Wang, J., Zhang, M., Chen, Y., Zhang, Y., Zhang, C., Hao, P. Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor. Mol Med 2015; 21(--):626-36. >>> Angiotensin (1-7), A779, PD123319; saline; SC; mice; Controls received mp w/ vehicle; animal info: Male BALB/c mice (6–8 wks old); functionality of mp verified by measurement of tumor volumes; cancer (Hepatocellular Carcinoma); peptides; Dose: (200 ng/kg/min) Ang-(1–7), (800 ng/kg/min) Ang-(1–7), (800 ng/kg/min) A779, (10 mg/kg/day) PD123319.

16188 Tamagawa, T., Shinoda, M., Honda, K., Furukawa, A., Kaji, K., Nagashima, H., Akasaka, R., Chen, J., Sessle, B. J., Yonehara, Y., Iwata, K. Involvement of Microglial P2Y12 Signaling in Tongue Cancer Pain. J Dent Res 2016; 95(-10-):1176-82. >>> MRS2395; DMSO; PBS; CSF/CNS (cisterna magna); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Fischer, 100-200g); 25% DMSO used; cancer (tongue squamous cell carcinoma SCC-158, JCRB0231; JCRB); behavioral testing (head-withdrawal); tissue perfusion (cisterna magna); used PE tubing 0.8mm diameter; MRS2395 is an P2Y12R antagonist;.

16136 Hesketh, A. J., Maloney, C., Behr, C. A., Edelman, M. C., Glick, R. D., Al-Abed, Y., Symons, M., Soffer, S. Z., Steinberg, B. M. The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation. PLoS One 2015; 10(-12-):e0145197. >>> Semapimod; IP; mice; Controls received mp w/ vehicle; animal info: Six week-old female nude NCr mice; cancer (sarcoma); dose-response (pg. 12); Semapimod aka CNI-1493; Dose: 5 mg/kg/day.

16132 Hamilton, L. K., Dufresne, M., Joppe, S. E., Petryszyn, S., Aumont, A., Calon, F., Barnabe-Heider, F., Furtos, A., Parent, M., Chaurand, P., Fernandes, K. J. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease. Cell Stem Cell 2015; 17(-4-):397-411. >>> Ara-C; Oleic Acid; AB142089; Ara-C; Oleic Acid; AB142089; CSF/CNS (cerebroventricular); mice; 1007D; 1004; Controls received mp w/ vehicle; animal info: 2-month-old WT or 3xTg-AD mice; functionality of mp verified by Analysis of brain sections by IMS; cancer; dose-response (pg 407); neurodegenerative (NSC impairment); enzyme inhibitor (SCD-1 inhibitor– AB142089); Dose: 500 mM Oleic Acid; 10mM C12 Oleic Acid conjugated to vehicle; 10mM C13 Oleic Acid conjugated to vehicle; 2% AraC; 40 mM SCD-1 inhibitor.

16131 Gujrati, M., Vaidya, A., Lu, Z. R. Multifunctional pH-Sensitive Amino Lipids for siRNA Delivery. Bioconjug Chem 2016; 27(-1-):19-35. >>> RNA, small interfering/EHCO; PEGylated EHCO; Mice (nude); Controls received treated with nonspecific PEGylated EHCO/siGFP nanoparticles (PEGGFP) and non-PEGylated EHCO/HIF-1ǝ; cancer; gene therapy, RNA nanoparticle infusion; peptides;“These results indicate that PEGylation can significantly improve the stability of EHCO/siRNA nanoparticles during storage in solution, possibly by preventing the aggregation of the nanoparticles and providing better protection to the siRNA cargo from degradation” (pg 31);.

16128 Giachino, C., Boulay, J. L., Ivanek, R., Alvarado, A., Tostado, C., Lugert, S., Tchorz, J., Coban, M., Mariani, L., Bettler, B., Lathia, J., Frank, S., Pfister, S., Kool, M., Taylor, V. A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. Cancer Cell 2015; 28(-6-):730-42. >>> Platelet-derived growth factor - A, human recombinant; CSF/CNS (forebrain lateral ventricle); mice; animal info: adult Hes5::GFP Notch-reporter mice; cancer (gliomas); brain tissue distribution;“increased PDGF signaling induces glioma-like growths from the subventricular zone (SVZ) in mice” (pg 731);.

16094 Barth, R. F., Yang, W., Nakkula, R. J., Byun, Y., Tjarks, W., Wu, L. C., Binns, P. J., Riley, K. J. Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors. Appl Radiat Isot 2015; 106(--):251-5. >>> N5-2OH; DMSO; CSF/CNS (intracerebral); IV; rat; 2001D; Controls received mp w/ vehicle, untreated controls; %35 of DMSO; cancer (brain tumor; F98 glioma model); tissue perfusion (brain tissue); brain tissue distribution; Animals were irradiated for 5 min at the MITR-II reactor;“intracerebral. administration of BPA did not increase the tumor boron uptake compared to that obtained following i.v. administration” (pg. 252); Dose: 500 ug.

16087 Zhao, Y., Detering, L., Sultan, D., Cooper, M. L., You, M., Cho, S., Meier, S. L., Luehmann, H., Sun, G., Rettig, M., Dehdashti, F., Wooley, K. L., DiPersio, J. F., Liu, Y. Gold Nanoclusters Doped with (64)Cu for CXCR4 Positron Emission Tomography Imaging of Breast Cancer and Metastasis. ACS Nano 2016; 10(-6-):5959-70. >>> AMD3100; PBS; SC; Mice; 2001; animal info (female, BALB/cve); cancer (breast 4T1); Dose (1 mg/day);.

16086 Zhao, Y., Masiello, D., McMillian, M., Nguyen, C., Wu, Y., Melendez, E., Smbatyan, G., Kida, A., He, Y., Teo, J. L., Kahn, M. CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells. Oncogene 2016; 35(-28-):3705-17. >>> ICG-001; Saline; Mice (NSG); 1004; Controls received mp w/ vehicle; animal info (female, NSG, 8-10 weeks old); cancer (chronic myelogenous leukemia K562); Dose (50 mg/kg/day);.

16082 Zhang, W., Liu, Y., Li, Y. F., Yue, Y., Yang, X., Peng, L. Targeting of Survivin Pathways by YM155 Inhibits Cell Death and Invasion in Oral Squamous Cell Carcinoma Cells. Cell Physiol Biochem 2016; 38(-6-):2426-37. >>> YM155; SC; Mice (nude); 1007D; Controls received mp w/ vehicle; animal info (female, nude, 5 weeks old); cancer (Oral squamous cell carcinoma SCC9); Dose (5 mg/kg/day); xenograph model;.

16078 Zenitani, M., Nojiri, T., Uehara, S., Miura, K., Hosoda, H., Kimura, T., Nakahata, K., Miyazato, M., Okuyama, H., Kangawa, K. C-type natriuretic peptide in combination with sildenafil attenuates proliferation of rhabdomyosarcoma cells. Cancer Med 2016; 5(-5-):795-805. >>> C-type natriuretic peptide; SC; Mice (nude); 1003D; Controls received mp w/ vehicle; animal info (male, C57BL6 or BALB/c nu/ny, 5 weeks old); functionality of mp verified by plasma levels (figure 4B); cancer (rhabdomyosarcoma RD-GC-B); xenograft model; Dose (2.5 ug/kg/min); Resultant plasma level (~600 pmol/L; see figure 4B);.

16062 Wang, X., Shi, C., Zhang, L., Bodman, A., Guo, D., Wang, L., Hall, W. A., Wilkens, S., Luo, J. Affinity-controlled protein encapsulation into sub-30 nm telodendrimer nanocarriers by multivalent and synergistic interactions. Biomaterials 2016; 101(--):258-71. >>> Telodendrimer nanoparticles, peptide-incorporated; Intratumoral; Mice (nude); Controls received mp w/ free peptide; animal info (female, athymic nude NCRU-Sp/Sp, 8 weeks old); cancer (glioblastoma U87); tissue perfusion (intratumoral); pumps primed overnight at 37C; Dose (0.5 ug/h); Brain coordinates (0.5 mm anterior to bregma and 2.5 mm lateral of midline);.

16049 Uchi, Y., Takeuchi, H., Matsuda, S., Saikawa, Y., Kawakubo, H., Wada, N., Takahashi, T., Nakamura, R., Fukuda, K., Omori, T., Kitagawa, Y. CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis. BMC Cancer 2016; 16(--):514. >>> AMD3100; SC; Mice (nude); 2001; Controls received mp w/ 0.1% BSA; animal info (female, BALB/c nude, 6 weeks old); pumps replaced every week; cancer (Esophageal squamous cell carcinoma TE4); xenograft model;.

15999 Hongu, T., Funakoshi, Y., Fukuhara, S., Suzuki, T., Sakimoto, S., Takakura, N., Ema, M., Takahashi, S., Itoh, S., Kato, M., Hasegawa, H., Mochizuki, N., Kanaho, Y. Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial beta1 integrin recycling. Nat Commun 2015; 6(--):7925. >>> SecinH3; DMSO; glycerol; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (male, Arf6 flox/flox, 8 weeks old); pumps replaced every 4 days; 50% DMSO used; 50% glycerol; cancer (B16 melanoma or LLC); xenograft model;.

15843 Jeffrey S. Willey, PhD, Daniel N. Bracey, MD, Patricia E. Gallagher, PhD,, E. Ann Tallant, PhD,, Walter F. Wiggins, MD, PhD,, Michael F. Callahan, PhD,, Thomas L. Smith, PhD,, Cynthia L. Emory, MD  JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 2016; 98(--):48-55. >>> Angiotensin (1-7); SC; Mice; 2004; animal info (male, CD-1, 25g); cancer (sarcoma); cardiovascular; peptides; Dose (24 ug/kg/hr);.

15829 Traci R. Tuttle, Michelle L. Mierzwa, Susanne I.Wells, Sejal R. Fox, Nira Ben-Jonathan  Cancer Letters 2016; 370(--):279-285. >>> Tadalafil; PEG 400; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (female, nu/nu athymic, 8 weeks old); cancer (head and neck; CAL 27); stress/adverse reaction: (see pg. 283)"There were no observed changes in weight or behavior of the treated mice"; xenograph study; Dose (1 mg/kg/day);.

15820 Shinya Sento, Eri Sasabe, Tetsuya Yamamoto  PLoS One 2016; 11(-2-):. >>> Heparin; SC; Mice; 2004; Controls received mp w/ saline; animal info (BALB/c nude, 5 weeks old); cancer (oral squamous carcinoma OSC-4);.

15790 Rui Lia, Yi Zhang, Mohamed Abdulkadir Mohameda, Xiang Weia, Cai Chenga  The International Journal of Biochemistry and Cell Biology 2016; 71(--):55-61. >>> AMD3100; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, A/HE, 12 weeks old); cancer (lung); immunology;.

15782 Andriana G Kotini, Elisa de Stanchina, Maria Themeli, Michel Sadelain, Eirini P Papapetrou  MOLECULAR THERAPY 2016; 5(--):. >>> Ganciclovir; PBS; SC; Mice (NSG); 1007D; animal info (female, NSG, 8 weeks old); pumps replaced every week; cancer (teratoma); Dose (5 mg/kg/day);.

15778 Ai Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Takuji Kawamura, Noriyuki Kashiyama, Emiko Ito, Tadashi Watabe, Shigeo Masuda, Koichi Toda, Jun Hatazawa, Eiichi Morii, Yoshiki Sawa  SCIENTIFIC REPORTS 2016; 6(--):1-13. >>> Tacrolimus; SC; Mice; 1002; cancer (teratocarcinoma); immunology; animal info (BALB/c); functionality of mp verified by plasma levels; pumps replaced after 14 days; BLI; Dose (1.5 mg/kg);.

15777 Zongming Jiang, Shaoyong Wu, Xiujuan Wu, Junfeng Zhong, Anqing Lv, Jing Jiao, Zhonghua Chen  International Journal of Cancer 2016; 138(--):2013-2020. >>> Rapamycin; CTOP; LY297002; DMSO; saline; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (Wistar, 200-250g); 50% DMSO used; cancer (breast; bone); dose-response (pg 2015); behavioral testing (hindpaw withdrawal latency); Rapamycin is an mTOR antagonist; CTOP is an MOR antagonist; LY297002 an a PI3K inhibitor;.

15723 Chani M. Becker,, Rajneet K. Oberoi,, Stephan J. McFarren,, Daniel M. Muldoon,, Deanna H. Pafundi,, Jenny L. Pokorny,, Debra H. Brinkmann,, John R. Ohlfest,, Jann N. Sarkaria,, David A. Largaespada,, and William F. Elmquist  NEURO-ONCOLOGY 2015; 17(-9-):1210-1219. >>> GNE-317; GDC-0980; DMSO; IP; Mice; 1003D; animal info (WT or TKO); functionality of mp verified by plasma levels; cancer (glioblastoma); Dose (GNE-317 5 ug/hour; GDC-0980 10 ug/hr);.

15252 Owens, P., Pickup, M.W., Novitskiy, S.V., Giltnane, J.M., Gorska, A.E., Hopkins, C.R., Hong, C.C., Moses, H.L., Owens, P. Inhibition of BMP signaling suppresses metastasis in mammary cancer. ONCOGENE 2015; 34(--):2437-2449. >>> DMH1; DMSO; Saline; Mice; 2006; Controls received mp w/ vehicle; animal info (female, MMTV.PyVMT, 7 weeks old); cancer (breast); DMH1 is a BMP (bone morphogenic protein) antagonist; long-term study;.

15188 Zhao, L., Xu, J.H., Liang, F., Li, A., Zhang, Y., Sun, J., Xu, J.H. Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. PLoS One 2015; 10(--):U1894-U1908. >>> Propranolol hydrochloride; ICI118,551; SC; Mice (nude); 1004; Animal info (male, BALB/C nu/nu, 4 weeks old); cancer (colon, HT-29);.

15171 Zhang, L.X., Ngo, J.A., Wetzel, M.D., Marchetti, D., Marchetti, D. Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer. NEOPLASIA 2015; 17(--):101-113. >>> Roneparstat; lapatinib; PBS; Mice (nude); Controls received mp w/ vehicle; animal info (athymic, nu/nu, 5-6 weeks old); cancer (brain metastatic breast cancer);.

15263 Zamykal, M., Martens, T., Matschke, J., Guenther, H.S., Kathagen, A., Schulte, A., Peters, R., Westphal, M., Lamszus, K., Lamszus, K. Inhibition of intracerebral glioblastoma growth by targeting the insulin-like growth factor 1 receptor involves different context-dependent mechanisms. NEURO-ONCOLOGY 2015; 17(--):1076-1085. >>> IMC-A12; Saline; CSF/CNS (intratumoral); Mice; 2004; Controls received mp w/ vehicle; animal info (Foxn1nu, 6-8 weeks old); cancer (glioblastoma); tissue perfusion (glioblastoma); IMC-A12 aka cixutumumab;.

15162 Yu, P., Petrus, M.N., Ju, W., Zhang, M., Conlon, K.C., Nakagawa, M., Maeda, M., Bamford, R.N., Waldmann, T.A., Waldmann, T.A. Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model. LEUKEMIA 2015; 29(--):556-566. >>> Compound E; PEG 300; SC; Mice (NOG); Controls received mp w/ PBS; animal info (NOG); cancer (leukemia, adult T-cell);.

15157 Yonezawa, T., Chen, K.H., Ghosh, M.K., Rivera, L., Dill, R., Ma, L.S., Villa, P.A., Kawaminami, M., Walker, A.M., Walker, A.M. Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer. CANCER LETTERS 2015; 366(--):84-92. >>> Prolactin, recombinant human; oligomer, splice-modulating; SC; Mice (NOD/SCID); Controls received mp w/ vehicle; animal info (female, BALB/cJ or NOD SCID, 8-9 weeks old); functionality of mp verified by plasma levels; pumps replaced every 28 days; cancer (breast); dose-response (pg 87);.

15156 Yassine, H., Caires, N.D., Depontieu, F., Scherpereel, A., Awad, A., Tsicopoulos, A., Leboeuf, C., Janin, A., Duez, C., Grigoriu, B., Lassalle, P., Lassalle, P. The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction. ONCOTARGET 2015; 6(--):2725-2735. >>> Endocan/S137A, recombinant human; PBS; SC; Mice (SCID); 2004; Controls received mp w/ vehicle; animal info (male, CB-17 scid/scid homozygous, 5-6 weeks old); functionality of mp verified by blood levels; cancer (colon adenocarcima HT-29); immunology;.

15148 Yamazaki, H., Takagi, S., Hosoya, K., Okumura, M., Takagi, S. Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. RESEARCH IN VETERINARY SCIENCE 2015; 99(--):137-144. >>> YM155; lomustine; Saline; SC; IP; Mice (nude); 1003D; 1007D; Controls received mp w/ vehicle; animal info (female, nude, 4 weeks old); pumps replaced every week; cancer (canine histiocytic sarcoma); 3 days of continuous infusion per week for 3 weeks; lomustine aka CCNU;.

15143 Wilson, C.L., Jurk, D., Fullard, N., Banks, P., Page, A., Luli, S., Elsharkawy, A.M., Gieling, R.G., Chakraborty, J.B., Fox, C., Richardson, C., Callaghan, K., Blair, G.E., Fox, N., Lagnado, A., Passos, J.F., Moore, A.J., Smith, G.R., Tiniakos, D.G., Mann, J., Oakley, F., Mann, D.A., Oakley, F. NFkappaB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nature Communications 2015; 6(--):U1-U13. >>> Antibody, Ly6G; immunoglobulin G2a, rat; SC; Mice; 2004; Animal info (male, DEN-injured nfkb1 -/- or WT, 22 weeks old); cancer (hepatocellular carcinoma);.

15141 Wermke, M., Camgoz, A., Paszkowski-Rogacz, M., Thieme, S., von Bonin, M., Dahl, A., Platzbecker, U., Theis, M., Ehninger, G., Brenner, S., Bornhaeuser, M., Buchholz, F., Wermke, M. RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug. BLOOD 2015; 125(--):3760-3768. >>> Fasudil; SC; Mice (NSG); Animal info (female, NSG, 4-6 weeks old); cancer (acute myeloid leukemia); immunology;.

15133 Wang, W.J., Sivakumar, W., Torres, S., Jhaveri, N., Vaikari, V.P., Gong, A., Howard, A., Golden, E.B., Louie, S.G., Schoenthal, A.H., Hofman, F.M., Chen, T.C., Chen, T.C. Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. Neurosurgical Focus 2015; 38(--):U112-U119. >>> Bevacizumab; Saline; CSF/CNS (intratumoral); Mice (nude); 1004; Controls received mp w/ vehicle; animal info (athymic, nu/nu); ALZET brain infusion kit used; cancer (glioma); immunology;"Bevacizumab was delivered into the tumor using chronic pump-mediated delivery, defined as“convection-enhanced delivery” or CED. This CED method was used because it has the advantage of achieving the desirable drug concentration in the microenvironment of the glioma while avoiding the use of high initial doses."pg 2;.

15077 Shakushiro, K., Kawano, H., Nakata, M., Kita, A., Maeda, A., Watanabe, S., Sako, K., Oku, N., Shakushiro, K. Formulation Design and Evaluation of Liposomal Sepantronium Bromide (YM155), a Small-Molecule Survivin Suppressant, Based on Pharmacokinetic Modeling and Simulation. PHARMACEUTICAL RESEARCH 2015; 32(--):238-247. >>> YM155; Saline; Mice (nude); 1007D; Controls received mp w/ vehicle; animal info (male, BALB/c nu/nu, 5 weeks old); cancer (prostate; malignant melanoma; lung);.

15066 Prasad, S., Gaedicke, S., Machein, M., Mittler, G., Braun, F., Hettich, M., Firat, E., Klingner, K., Schueler, J., Wider, D., Waesch, R.M., Herold-Mende, C., Elsaesser-Beile, U., Niedermann, G., Niedermann, G. Effective Eradication of Glioblastoma Stem Cells by Local Application of an AC133/CD133-Specific T-cell-Engaging Antibody and CD8 T Cells. CANCER RESEARCH 2015; 75(--):2166-2176. >>> Antibody, AC133xCD3 bispecific; PBS; CSF/CNS; Mice (nude); 1007D; Controls received mp w/ control antibody; animal info (NMR I nude, 6-8 weeks old); ALZET brain infusion kit 3 used; cancer (glioblastoma multiforme); immunology; cyanoacrylate adhesive;.

15060 Pitt, L.A., Tikhonova, A.N., Hu, H., Trimarchi, T., King, B., Gong, Y.X., Sanchez-Martin, M., Tsirigos, A., Littman, D.R., Ferrando, A.A., Morrison, S.J., Fooksman, D.R., Aifantis, I., Schwab, S.R., Aifantis, I. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. CANCER CELL 2015; 27(--):755-768. >>> AMD3465; PBS; SC; Mice (NOD/SCID); 2002; Controls received mp w/ vehicle; animal info (female, C57BL6, 6-8 weeks old); cancer (leukemia); immunology;.

15055 Nojiri, T., Hosoda, H., Tokudome, T., Miura, K., Ishikane, S., Otani, K., Kishimoto, I., Shintani, Y., Inoue, M., Kimura, T., Sawabata, N., Minami, M., Nakagiri, T., Funaki, S., Takeuchi, Y., Maeda, H., Kidoya, H., Kiyonari, H., Shioi, G., Arai, Y., Hasegawa, T., Takakura, N., Hori, M., Ohno, Y., Miyazato, M., Mochizuki, N., Okumura, M., Kangawa, K., Kangawa, K. Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):4086-4091. >>> Atrial natriuretic peptide; Saline; IV (jugular); Mice (nude); 1002; 2004; Controls received mp w/ vehicle; animal info (BALB/c nu/nu, 6 weeks old); cancer (lung); cardiovascular; immunology; used mouse jugular catheter (#7702); bp measured using tail cuff;.

15941 Monterrubio, C., Paco, S., Vila-Ubach, M., Rodriguez, E., Glisoni, R., Lavarino, C., Schaiquevich, P., Sosnik, A., Mora, J., Carcaboso, A. M. Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts. Pharm Res 2015; 32(-9-):2889-900. >>> Irinotecan; SC; Mice (nude); 2001D; animal info (athymic, nude)); functionality of mp verified by plasma levels; cancer (neuroblastoma; HSJD-NB-003 or HSJD-NB-004); xenograft model; Dose (130 ug/h);.

15011 Liu, J., Deng, G.H., Zhang, J., Wang, Y., Xia, X.Y., Luo, X.M., Deng, Y.T., He, S.S., Mao, Y.Y., Peng, X.C., Weil, Y.Q., Jiang, Y., Jiang, Y. The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models. PSYCHONEUROENDOCRINOLOGY 2015; 52(--):130-142. >>> Norepinephrine bitartrate hydrate; propranolol; Ascorbic acid; PBS; SC; Mice; 1004; Animal info (female, BALB/c, 5-7 weeks old); cancer (colorectal carcinoma, human);.

15006 Li, H., Jiang, X., Yu, Y., Huang, W., Xing, H., Agar, N.Y., Yang, H.W., Yang, B., Carroll, R.S., Johnson, M.D., Johnson, M.D. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. ONCOGENE 2015; 34(--):1432-1441. >>> Purvalanol A; Saline; CSF/CNS; Mice (nude); Controls received mp w/ vehicle; animal info (male, nude, 6 weeks old); cancer (glioblastoma);.

14997 Kogo, R., How, C., Chaudary, N., Bruce, J., Shi, W., Hill, R.P., Zahedi, P., Yip, K.W., Liu, F.F., Liu, F.F. The microRNA-218similar toSurvivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. ONCOTARGET 2015; 6(--):1090-1100. >>> YM155; SC; Mice (SCID); 1003D; Controls received mp w/ saline; animal info (female, SCID, 6-8 weeks old); pumps replaced every week - YM155 administered 3 days per week for 2 weeks; cancer (cervical); YM155 is a small molecule survivin inhibitor;.

14970 Hurst, R.E., Hauser, P.J., You, Y., Bailey-Downs, L.C., Bastian, A., Matthews, S.M., Thorpe, J., Earle, C., Bourguignon, L.Y.W., Ihnat, M.A., Hurst, R.E. Identification of novel drugs to target dormant micrometastases. BMC CANCER 2015; 15(--):U1-U12. >>> DT310; DT320; SC; Mice; 2004; Animal info (female, BALB/c, 8 weeks old); cancer (metastatic tumor);.

14928 Garofalo, S., D'Alessandro, G., Chece, G., Brau, F., Maggi, L., Rosa, A., Porzia, A., Mainiero, F., Esposito, V., Lauro, C., Benigni, G., Bernardini, G., Santoni, A., Limatola, C., Limatola, C. Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice. Nature Communications 2015; 6(--):U26-U38. >>> Interleukin-15; brain-derived neurotrophic factor; PBS; CSF/CNS (striatum); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6, 3 weeks or 2 months old); ALZET brain infusion kit 3 used; cancer (glioma, U87MG human); tissue perfusion (right striatum); immunology; pumps primed in 37C saline overnight;.

14940 Gardner, J.K., Mamotte, C.D.S., Patel, P., Yeoh, T.L., Jackaman, C., Nelson, D.J., Nelson, D.J. Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function. PLoS One 2015; 10(--):U1192-U1220. >>> TOFA; DMSO; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (female, C57BL6J, 6-8 weeks old); cancer (mesothelioma); immunology; TOFA aka 5-tetradecycloxy-2-furoic acid;.

14905 Daft, P.G., Yang, Y., Napierala, D., Zayzafoon, M., Zayzafoon, M. The Growth and Aggressive Behavior of Human Osteosarcoma Is Regulated by a CaMKII-Controlled Autocrine VEGF Signaling Mechanism. PLoS One 2015; 10(--):U431-U450. >>> KN-93; CBO-P11; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, Foxn1 nu, 6 weeks old); cancer (osteosarcoma);.

14889 Choi, M.J., Cho, K.H., Lee, S., Bae, Y.J., Jeong, K.J., Rha, S.Y., Choi, E.J., Park, J.H., Kim, J.M., Lee, J.S., Mills, G.B., Lee, H.Y., Lee, H.Y. hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. ONCOGENE 2015; 34(--):3402-3412. >>> Norepinephrine; Saline; ascorbic acid; SC; Mice (nude); 1004; Controls received mp w/ vehicle; animal info (female, nude, 4 weeks old); cancer (ovarian);.

14869 Chan, K.C., Chan, L.S., Ip, J.C.Y., Lo, C., Yip, T.T.C., Ngan, R.K.C., Wong, R.N.S., Lo, K.W., Ng, W.T., Lee, A.W.M., Tsao, G.S.W., Kahn, M., Lung, M.L., Mak, N.K., Mak, N.K. Therapeutic targeting of CBP/beta-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin. SCIENTIFIC REPORTS 2015; 5(--):U18-U29. >>> ICG-001; PBS; SC; Mice (nude); 1004; Controls received mp w/ vehicle; animal info (female, athymic BALB/c, nu/nu, 6-8 weeks old); cancer (nasopharyngeal carcinoma);.

14910 Carew, J.S., Espitia, C.M., Zhao, W.G., Mita, M.M., Mita, A.C., Nawrocki, S.T., Nawrocki, S.T. Targeting Survivin Inhibits Renal Cell Carcinoma Progression and Enhances the Activity of Temsirolimus. MOLECULAR CANCER THERAPEUTICS 2015; 14(--):1404-1413. >>> YM155; Mice (nude); Animal info (female, nude BALB/c); cancer (renal);.

14859 Cardinale, V., Renzi, A., Carpino, G., Torrice, A., Bragazzi, M.C., Giuliante, F., DeRose, A.M., Fraveto, A., Onori, P., Napoletano, C., Franchitto, A., Cantafora, A., Grazi, G., Caporaso, N., D'Argenio, G., Alpini, G., Reid, L.M., Gaudio, E., Alvaro, D., Alvaro, D. Profiles of Cancer Stem Cell Subpopulations in Cholangiocarcinomas. AMERICAN JOURNAL OF PATHOLOGY 2015; 185(--):1724-1739. >>> Cyclosporine; IP; Mice; 1004; Animal info (male, BALB/c, 13 weeks old); cancer (cholangiocarcinoma);.

14853 Brun, S.N., Markant, S.L., Esparza, L.A., Garcia, G., Terry, D., Huang, J.M., Pavlyukov, M.S., Li, X.N., Grant, G.A., Crawford, J.R., Levy, M.L., Conway, E.M., Smith, L.H., Nakano, I., Berezov, A., Greene, M.I., Wang, Q., Wechsler-Reya, R.J., Wechsler-Reya, R.J. Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. ONCOGENE 2015; 34(--):3770-3779. >>> YM155; Saline; SC; Mice (nude); 2004; Controls received mp w/ vehicle; animal info (CD-1 nu/nu, 5-8 weeks old); cancer (medulloblastoma);“...since YM155 has a short half-life, we used osmotic pumps for delivery.” pg 3773-3774;.

14837 Bao, Y.J., Gao, Y.B., Hou, W., Yang, L.P., Kong, X.Y., Zheng, H.G., Li, C.H., Hua, B.J., Hua, B.J. Engagement of signaling pathways of protease-activated receptor 2 and -opioid receptor in bone cancer pain and morphine tolerance. INTERNATIONAL JOURNAL OF CANCER 2015; 137(--):1475-1483. >>> FSLLRY-NH2; Saline; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (Wistar 200-250g); cancer (bone); no stress (see pg. 1476); behavioral testing (mechanical paw withdrawal, thermal hyperalgesia); peptides;.

14811 Ager, E.I., Kozin, S.V., Kirkpatrick, N.D., Seano, G., Kodack, D.P., Askoxylakis, V., Huang, Y.H., Goel, S., Snuderl, M., Muzikansky, A., Finkelstein, D.M., Dransfield, D.T., Devy, L., Boucher, Y., Fukumura, D., Jain, R.K., Jain, R.K. Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy. JOURNAL OF THE NATIONAL CANCER INSTITUTE 2015; 107(--):U137-U148. >>> 1400W dihydrochloride; SC; Mice (nude); 1002; Animal info (female, nu/nu, 6-8 weeks old); cancer (breast); enzyme inhibitor (nitric oxide synthase); immunology;.

14807 Rolon-Reyes, K., Kucheryavykh, Y.V., Cubano, L.A., Inyushin, M., Skatchkov, S.N., Eaton, M.J., Harrison, J.K., Kucheryavykh, L.Y., Kucheryavykh, L.Y. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS One 2015; 10(--):U2306-U2323. >>> Ganciclovir; CSF/CNS (intratumoral); Mice (transgenic); 2004; Controls received mp w/ saline, normal; animal info (male, CD11b-HSVTK trangenic); ALZET brain infusion kit used; cancer (glioma GL261);.

14766 Tsutsumi, Y., Nomiyama, T., Kawanami, T., Hamaguchi, Y., Terawaki, Y., Tanaka, T., Murase, K., Motonaga, R., Tanabe, M., Yanase, T., Nomiyama, T. Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. PLoS One 2015; 10(--):U743-U759. >>> Exendin-4; metformic; SC; Mice; 1004; Control animsl received mp w/ saline; animal info (athymic CAcN.Cg-Foxn1nu/CrlCrlj, non-diabetic, male); one group received mixture of exendin-4 and metformin; cancer (prostate); long-term study;.

14759 Agarwal, H.K., Khalil, A., Ishita, K., Yang, W.L., Nakkula, R.J., Wu, L.C., Ali, T., Tiwari, R., Byun, Y., Barth, R.F., Tjarks, W., Tjarks, W. Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015; 100(--):197-209. >>> Boron; DMSO; CSF/CNS; Rat; 2001D; Animal info (Fischer); functionality of mp verified by distributon of agent in brain; 35% DMSO used; cancer (glioma);brain tissue distribution;.

14554 Minami, Y., Sasaki, T., Bochimoto, H., Kawabe, J., Endo, S., Hira, Y., Watanabe, T., Okumura, S., Hasebe, N., Ohsaki, Y., Sasaki, T. Prostaglandin 12 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis. INTERNATIONAL JOURNAL OF ONCOLOGY 2015; 46(--):548-554. >>> Betaprost sodium; SC; Mice; Controls received mp w/ water, distilled; animal info (female, C57BL6, 8-10 weeks old, 20-25g); cancer (lung); Betaprost sodium aka BPS; Betaprost sodium is a stable PGI2 analog;.

14496 Yamazaki, S., Lam, J.L., Zou, H.Y., Wang, H., Smeal, T., Vicini, P., Yamazaki, S. Mechanistic Understanding of Translational Pharmacokinetic-Pharmacodynamic Relationships in Nonclinical Tumor Models: A Case Study of Orally Available Novel Inhibitors of Anaplastic Lymphoma Kinase. Drug Metabolism and Disposition 2015; 43(--):54-62. >>> PF06463922; PF06471402; DMSO; PEG 400; cremophor; SC; Mice (nude); Controls received mp w/ vehicle; animal info (female, nu/nu, athymic); functionality of mp verified by blood samples; 45% DMSO used; 40% PEG400 used; 15% cremophor used; comparison of gavage vs mp; cancer (lung); dose-response (pg 57); PF06463922 and PF06471402 are novel small molecules, second-generation anaplastic lymphoma kinase inhibitors;.

14394 Seib, F.P., Berry, J.E., Shiozawa, Y., Taichman, R.S., Kaplan, D.L., Kaplan, D.L. Tissue engineering a surrogate niche for metastatic cancer cells. Biomaterials 2015; 51(--):313-319. >>> Stromal cell-derived factor 1; receptor activator of nuclear factor kappa-B ligand; Bone; Mice (NOD/SCID; nude); 1004; Controls received mp w/ PBS; animal info (female, NOD/SCID, 6-10 weeks old; male, athymic nude, 6-10 weeks old); cancer (breast; prostate); receptor activator of nuclear factor kappa-B ligand aka RANKL; Stromal cell-derived factor 1 aka SDF-1;.

14374 Rossdeutscher, L., Li, J., Luco, A.L., Fadhil, I., Ochietti, B., Camirand, A., Huang, D.C., Reinhardt, T.A., Muller, W., Kremer, R., Kremer, R. Chemoprevention Activity of 25-Hydroxyvitamin D in the MMTV-PyMT Mouse Model of Breast Cancer. Cancer Prevention Research 2015; 8(--):120-128. >>> Dihydroxycholecalciferol, 1,25-; hydroxycholecalciferol, 25-,; Ethanol; saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (female, MMTV-PyMT, 4 weeks old); functionality of mp verified by blood levels; pumps replaced every 4 weeks; 20% ethanol used; cancer (breast); long-term study;.

14733 Faria, C.C., Golbourn, B.J., Dubuc, A.M., Remke, M., Diaz, R.J., Agnihotri, S., Luck, A., Sabha, N., Olsen, S., Wu, X.C., Garzia, L., Ramaswamy, V., Mack, S.C., Wang, X., Leadley, M., Reynaud, D., Ermini, L., Post, M., Northcott, P.A., Pfister, S.M., Croul, S.E., Kool, M., Korshunov, A., Smith, C.A., Taylor, M., Rutka, J.T., Rutka, J.T. Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma. Cancer Research 2015; 75(--):134-146. >>> Foretinib; Cremophor; CSF/CNS; Mice; 2004; Controls received mp w/ vehicle; animal info (Ptch +/- Sleeping Beauty transposition, PD30-PD35); functionality of mp verified by MALDI-TOF imagining; 10% cremophor used; cancer (medulloblastoma);"To explore the potential use of foretinib for intrathecal therapy in neuro-oncology, we used osmotic pumps to deliver the drug into the lateral ventricles of mice... these studies demonstrate for the first time, to our knowledge, that foretinib crosses the blood–brain barrier and can be safely administered as intrathecal therapy."pg 139;.

14683 Carry, J.C., Clerc, F., Minoux, H., Schio, L., Mauger, J., Nair, A., Parmantier, E., Le Moigne, R., Delorme, C., Nicolas, J.P., Krick, A., Abecassis, P.Y., Crocq-Stuerga, V., Pouzieux, S., Delarbre, L., Maignan, S., Bertrand, T., Bjergarde, K., Ma, N.N., Lachaud, S., Guizani, H., Lebel, R., Doerflinger, G., Monget, S., Perron, S., Gasse, F., ngouillant-Boniface, O., Filoche-Romme, B., Murer, M., Gontier, S., Prevost, C., Monteiro, M.L., Combeau, C., Carry, J.C. SARI 56497, an Exquisitely Selective Inhibitor of Aurora Kinases. Journal of Medicinal Chemistry 2015; 58(--):362-375. >>> Compound 47; SC; Mice (SCID); 2001D; Animal info (female, SCID); cancer (human acute meyloid leukemia EOL-1, human colon adenocarcinoma HCT116); dose-response (pg 369); Compound 47 aka SAR156497; SAR156497 is an aurora kinase inhibitor;.

14636 Hiramatsu, R., Kawabata, S., Tanaka, H., Sakurai, Y., Suzuki, M., Ono, K., Miyatake, S.I., Kuroiwa, T., Hao, E., Vicente, M.G.H., Kawabata, S. Tetrakis(p-Carboranylthio-Tetrafluorophenyl)Chlorin (TPFC): Application for Photodynamic Therapy and Boron Neutron Capture Therapy. Journal of Pharmaceutical Sciences 2015; 104(--):962-970. >>> TPFC; CSF/CNS; Rat; 2001D; Animal info (male, 200-250 g, F344 Fischer); ALZET brain infusion kit 2 used; TPFC, also known as Tetrakis(p-Carboranylthio-Tetrafluorophenyl)Chlorin, is a carboranyl-containing chlorin of high boron content; cancer (glioma); tissue perfusion; convection-enhanced delivery.


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What researchers are saying...

“In the majority of studies examining nicotine withdrawal, nicotine was delivered y an osmotic pump... The osmotic pump allows for the continuous delivery of nicotine at a controlled rate for a specified amount of time. An advantage of this delivery protocol is that nicotine levels in the bloodstream remain fairly constant, much like those of human chronic smokers. Discontinuing the delivery of nicotine by removal of the pump or interfering with nicotine’s effect on the central nervous system induces a withdrawal reaction... Accordingly, this experiment sought to replicate previous work using a rodent model of nicotine withdrawal developed by Malin et al. (1992) that has become widely used..., and which implements the osmotic pump as the nicotine delivery mechanism.” Besheer et al., Behavioral Neuroscience 2003;117(2):327-340.