References on the Administration of Cannabinoids Using ALZET® Osmotic Pumps

P7108 Paria,B.C., Ma,W., Andrenyak,D.M., Schmid,P.C., Schmid,H.H.O., Moody,D.E., Deng,H., Makriyannis,A., Dey,S.K. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors1. Biology of Reproduction 1998; 58(--):1490-1495. >>> Cannabinol, delta-9-tetrahydro-; SR141716A; Propylene glycol; ethanol; SC; Mice; 1007D; 3-4 days; Controls received mp w/ the less active (+)THC stereoisomer; functionality of mp verified by plasma THC levels.

P5754 Galve-Roperh,I., Sanchez,C., Cortes,M.L., Gomez Del Pulgar,T., Izquierdo,M., Guzman,M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000; 6(-3-):313-319. >>> WIN-55,212-2; Cannabinol, delta-9-tetrahydro-; PBS; BSA; CSF/CNS (intratumoral); Rat; 2001; 7 days; Tissue perfusion (tumor); cancer; WIN-55,212-2 is a potent synthetic cannabinol agonist.

P2491 Colasanti,B.K. A comparison of the ocular and central effects of delta-9 tetrahydrocannabinol and cannabigerol. J.Ocular Pharmacol. 1990; 6(-4-):259-269. >>> Cannabinol, delta-9-tetrahydro-; Cannabigerol; PEG 400; Eye (cornea); cat; 9 days; controls received mp w/ vehicle; dose-response (p.262); unilateral delivery.

P1511 Colasanti,B.K. Intraocular pressure, ocular toxicity and neurotoxicity in response to 11-hydroxy-delta9-tetrahydrocannabinol and 1-nantradol. J.Ocular Pharmacol. 1985; 1(-2-):123-135. >>> Cannabinol, tetrahydro-; Nantradol, 1-; PEG 400; Eye; cat; 2001; 9 days; topical application; tissue perfusion.

P0652 Colasanti,B.K., Brown,R.E., Craig,C.R. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. Gen.Pharmacol. 1984; 15(-6-):479-484. >>> Cannabidiol; Marihuana extract; Cannabinol, delta-9-tetrahydro-; PEG; Eye (cornea); cat; 9 days; mp model not stated; comparison of acute topical admin/ injec vs. mp infusion; comparison of agents effects; agents admin. topically to cat corneas; tissue perfusion.

P0577 Colasanti,B.K., Craig,C.R., Allara,R.D. Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol. Exp.Eye Res. 1984; 39(-3-):251-259. >>> Cannabigerol; Cannabinol; PEG 400; Eye; cat; 9 days; mp model not stated; comparison of agents effects; intermittent eye drop admin. vs. mp infusion; tissue perfusion.

P0466 Colasanti,B.K., Powell,S.R., Craig,C.R. Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta9-tetrahydrocannabinol or cannabichromene. Exp.Eye Res. 1984; 38(--):63-71. >>> Cannabichromene; Cannabinol, delta-9-tetrahydro-; PEG 400; Eye (cornea); cat; 2001; 9 days; comparison of agents effects; pump implanted sc and connected via sc tubing to cornea; tissue perfusion.


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“We administered nicotine to achieve a steady-state concentration, using subcutaneously implanted minipumps, a technique that avoids the episodic hypoxic-ischemic episodes that accompany nicotine injections, and that also sidesteps the inherent problems of repeated handling stress and episodic withdrawal between injections” Slotkin et al., Neurotoxicology and Teratology 2002; 24:369-384.