References on the Administration of Cannabinoids Using ALZET® Osmotic Pumps

P7108 Paria,B.C., Ma,W., Andrenyak,D.M., Schmid,P.C., Schmid,H.H.O., Moody,D.E., Deng,H., Makriyannis,A., Dey,S.K. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors1. Biology of Reproduction 1998; 58(--):1490-1495. >>> Cannabinol, delta-9-tetrahydro-; SR141716A; Propylene glycol; ethanol; SC; Mice; 1007D; 3-4 days; Controls received mp w/ the less active (+)THC stereoisomer; functionality of mp verified by plasma THC levels.

P5754 Galve-Roperh,I., Sanchez,C., Cortes,M.L., Gomez Del Pulgar,T., Izquierdo,M., Guzman,M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000; 6(-3-):313-319. >>> WIN-55,212-2; Cannabinol, delta-9-tetrahydro-; PBS; BSA; CSF/CNS (intratumoral); Rat; 2001; 7 days; Tissue perfusion (tumor); cancer; WIN-55,212-2 is a potent synthetic cannabinol agonist.

P2491 Colasanti,B.K. A comparison of the ocular and central effects of delta-9 tetrahydrocannabinol and cannabigerol. J.Ocular Pharmacol. 1990; 6(-4-):259-269. >>> Cannabinol, delta-9-tetrahydro-; Cannabigerol; PEG 400; Eye (cornea); cat; 9 days; controls received mp w/ vehicle; dose-response (p.262); unilateral delivery.

P1511 Colasanti,B.K. Intraocular pressure, ocular toxicity and neurotoxicity in response to 11-hydroxy-delta9-tetrahydrocannabinol and 1-nantradol. J.Ocular Pharmacol. 1985; 1(-2-):123-135. >>> Cannabinol, tetrahydro-; Nantradol, 1-; PEG 400; Eye; cat; 2001; 9 days; topical application; tissue perfusion.

P0652 Colasanti,B.K., Brown,R.E., Craig,C.R. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. Gen.Pharmacol. 1984; 15(-6-):479-484. >>> Cannabidiol; Marihuana extract; Cannabinol, delta-9-tetrahydro-; PEG; Eye (cornea); cat; 9 days; mp model not stated; comparison of acute topical admin/ injec vs. mp infusion; comparison of agents effects; agents admin. topically to cat corneas; tissue perfusion.

P0577 Colasanti,B.K., Craig,C.R., Allara,R.D. Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol. Exp.Eye Res. 1984; 39(-3-):251-259. >>> Cannabigerol; Cannabinol; PEG 400; Eye; cat; 9 days; mp model not stated; comparison of agents effects; intermittent eye drop admin. vs. mp infusion; tissue perfusion.

P0466 Colasanti,B.K., Powell,S.R., Craig,C.R. Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta9-tetrahydrocannabinol or cannabichromene. Exp.Eye Res. 1984; 38(--):63-71. >>> Cannabichromene; Cannabinol, delta-9-tetrahydro-; PEG 400; Eye (cornea); cat; 2001; 9 days; comparison of agents effects; pump implanted sc and connected via sc tubing to cornea; tissue perfusion.


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“In order to investigate the in vivo role of MMPs, we established a rodent model of glioma progression... We chose continuous infusion using an osmotic pump as the method for delivering TIMP into the tumor. This paradigm allowed aggressive glioma development and circumvented the problem of the blood brain barrier disturbing reagent delivery following intravenous delivery.” Takahashi et al., Pharmacological Research 2002;46(2):155-163.