References on the Administration of Cannabinoids Using ALZET® Osmotic Pumps

P7108 Paria,B.C., Ma,W., Andrenyak,D.M., Schmid,P.C., Schmid,H.H.O., Moody,D.E., Deng,H., Makriyannis,A., Dey,S.K. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors1. Biology of Reproduction 1998; 58(--):1490-1495. >>> Cannabinol, delta-9-tetrahydro-; SR141716A; Propylene glycol; ethanol; SC; Mice; 1007D; 3-4 days; Controls received mp w/ the less active (+)THC stereoisomer; functionality of mp verified by plasma THC levels.

P5754 Galve-Roperh,I., Sanchez,C., Cortes,M.L., Gomez Del Pulgar,T., Izquierdo,M., Guzman,M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000; 6(-3-):313-319. >>> WIN-55,212-2; Cannabinol, delta-9-tetrahydro-; PBS; BSA; CSF/CNS (intratumoral); Rat; 2001; 7 days; Tissue perfusion (tumor); cancer; WIN-55,212-2 is a potent synthetic cannabinol agonist.

P2491 Colasanti,B.K. A comparison of the ocular and central effects of delta-9 tetrahydrocannabinol and cannabigerol. J.Ocular Pharmacol. 1990; 6(-4-):259-269. >>> Cannabinol, delta-9-tetrahydro-; Cannabigerol; PEG 400; Eye (cornea); cat; 9 days; controls received mp w/ vehicle; dose-response (p.262); unilateral delivery.

P1511 Colasanti,B.K. Intraocular pressure, ocular toxicity and neurotoxicity in response to 11-hydroxy-delta9-tetrahydrocannabinol and 1-nantradol. J.Ocular Pharmacol. 1985; 1(-2-):123-135. >>> Cannabinol, tetrahydro-; Nantradol, 1-; PEG 400; Eye; cat; 2001; 9 days; topical application; tissue perfusion.

P0652 Colasanti,B.K., Brown,R.E., Craig,C.R. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. Gen.Pharmacol. 1984; 15(-6-):479-484. >>> Cannabidiol; Marihuana extract; Cannabinol, delta-9-tetrahydro-; PEG; Eye (cornea); cat; 9 days; mp model not stated; comparison of acute topical admin/ injec vs. mp infusion; comparison of agents effects; agents admin. topically to cat corneas; tissue perfusion.

P0577 Colasanti,B.K., Craig,C.R., Allara,R.D. Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol. Exp.Eye Res. 1984; 39(-3-):251-259. >>> Cannabigerol; Cannabinol; PEG 400; Eye; cat; 9 days; mp model not stated; comparison of agents effects; intermittent eye drop admin. vs. mp infusion; tissue perfusion.

P0466 Colasanti,B.K., Powell,S.R., Craig,C.R. Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta9-tetrahydrocannabinol or cannabichromene. Exp.Eye Res. 1984; 38(--):63-71. >>> Cannabichromene; Cannabinol, delta-9-tetrahydro-; PEG 400; Eye (cornea); cat; 2001; 9 days; comparison of agents effects; pump implanted sc and connected via sc tubing to cornea; tissue perfusion.


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“This study demonstrates the value of osmotic pumps as effective delivery vehicles for drugs in wild demersal fish.” (p.1024). “We conclude that the administration of T3 by osmotic pumps is an effective means of creating experimental hyperthyroidism in wild Atlantic cod.Similarly, the administration of methimazole, thiourea, or testosterone with osmotic pumps was effective in rendering cod hypothyroid.” (p.1025) Comeau et al., Transactions of the American Fisheries Society 2003;132:1021-1026.