References on the Administration of Corticosterone Using ALZET® Osmotic Pumps

16302 Benlloch, M., Obrador, E., Valles, S. L., Rodriguez, M. L., Sirerol, J. A., Alcacer, J., Pellicer, J. A., Salvador, R., Cerda, C., Saez, G. T., Estrela, J. M. Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism. Antioxid Redox Signal 2016; 24(-17-):974-90. >>> Pterostilbene, Corticosterone; DMSO, Ethanol; PEG400; IV (jugular); mice; Controls received mp w/ vehicle; animal info Female nu/nu nude mice (6–8 weeks); functionality of mp verified by plasma levels, pg 979; functionality of mp verified by plasma levels, pg 979; Pterostilbene is a natural dimethoxylated analog of resveratrol; Mice xenograft models; Dose (50 mg/ml Pter; 0.3 ug/hr corticosterone); Resultant plasma level (pg. 979);.

15990 Maayan, R., Hirsh, L., Yadid, G., Weizman, A. Dehydroepiandrosterone Attenuates Cocaine-Seeking Behaviour Independently of Corticosterone Fluctuations. J Neuroendocrinol 2015; 27(-11-):819-26. >>> Corticosterone; DMSO; SC; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-350g); functionality of mp verified by plasma levels; behavioral testing (lever pressing); dependence; Dose (15 mg/kg);.

15205 Claflin, D.I., Greenfield, L.R., Hennessy, M.B. Modest elevation of corticosterone in preweanling rats impairs subsequent trace eyeblink conditioning during the juvenile period. BEHAVIOURAL BRAIN RESEARCH 2014; 258(-;-):19-26. >>> Corticosterone; PEG 400; SC; Rat; 1003D; Controls received mp w/ vehicle; animal info (Long-Evans, PND15); functionality of mp verified by plasma levels pg22; no stress"Animals recovered quickly..."(see pg.20); post op. care (antibiotic ointment on wound, buprenorphine (0.052 mg/kg, heating pad until responsive and then returned to dam);“The corticosterone pellet was designed to produce a low, constant release of hormoneover a 21-day period, but plasma assays showed otherwise. There was a large supraphysiological increase in circulating corticoste-rone levels (to ∼80 ug/dl) for about three days after implantationand a return tonormal levels by the time testing occurred...In the present study, we administered cor-ticosterone using an alternative, more reliable method that yielded the low level (within a normal physiological range) and constantrate of delivery we had originally expected. Furthermore, since the∼3-day period of elevation in the previous study was sufficient toproduce lasting effects on behavior, we chose to use an osmotic mini-pump that was designed to deliver corticosterone at a lowand constant rate over a 3-day period only. ” pg 20; pumps primed for 24 hours in sterile saline;.

15940 Morris, D. J., Latif, S. A., Brem, A. S. An alternative explanation of hypertension associated with 17alpha-hydroxylase deficiency syndrome. Steroids 2014; 79(--):44-8. >>> corticosterone; progesterone, hydroxy-; Propylene glycol; sc; rat; Controls received mp w/ vehicle; animal info: adrenally intact rats; functionality of mp verified by measuring systolic blood pressure pg 46; replacement therapy (the agents infused); Dose: 5 ug/hr of both agents.

14902 Cuffe, J.S.M., Steane, S., Moritz, K.M., Paravicini, T.M., Paravicini, T.M. Differential mRNA Expression and Glucocorticoid-Mediated Regulation of TRPM6 and TRPM7 in the Heart and Kidney throughout Murine Pregnancy and Development. PLoS One 2015; 10(--):U1394-U1410. >>> Dexamethasone sodium phosphate; corticosterone; Saline; SC; Mice (pregnant); 1003D; Controls received mp w/ saline; animal info (female, E12.5, C57Bl6J, 8-10 weeks old); teratology; cardiovascular;.

14319 Nelson, B.F., Daunt, F., Monaghan, P., Wanless, S., Butler, A., Heidinger, B.J., Newell, M., Dawson, A., Dawson, A. Protracted treatment with corticosterone reduces breeding success in a long-lived bird. General and Comparative Endocrinology 2015; 210(--):38-45. >>> Corticosterone; PEG 400; SC; Bird (kittiwake); 2002; Controls received mp w/ vehicle; animal info (late incubation, 380g); functionality of mp verified by serum levels; Multiple pumps per animal (2);.

14630 Callaghan, B.L., Richardson, R., Callaghan, B.L. Early Emergence of Adult-Like Fear Renewal in the Developing Rat After Chronic Corticosterone Treatment of the Dam or the Pups. Behavioral Neuroscience 2014; 128(--):594-602. >>> Corticosterone; Water, deionized; SC; Rat (neonate); 1007D; Control animals received mp w/ vehicle; animal info (naive, Sprague Dawley, P7). no stress pg 595-596."The entire surgery took less than 5 min and the rats recovered well. The dorsal placement of the micropump was chosen because it does not interfere with the feeding position of pups."pg 595."...dams in the current studies tolerated the pups well after both surgeries and there were no instances of cannibalism or obvious abuse (e.g., bite marks)"pg 596; pumps removed after 1 week;.

13996 Wosiski-Kuhn, M., Erion, J.R., Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., Stranahan, A.M., Stranahan, A.M. Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice. Psychoneuroendocrinology 2014; 42(--):165-177. >>> Corticosterone; Cyclodextrin, 2-hydroxypropyl-B;; CSF/CNS (hippocampus); Mice; Controls received mp w/ vehicle and aCSF; animal info (male, C57BL6J or db/db, 5 weeks old); functionality of mp verified by hippocampal corticosterone levels; Multiple pumps per animal (2); behavioral testing (y-maze apparatus); tissue perfusion (bilateral hippocampi); immunology; Cannula placement verified via histology; used Plastics One bilateral cannula; bilateral infusion;.

13873 Mueller, A.D., Parfyonov, M., Pavlovski, I., Marchant, E.G., Mistlberger, R.E. The inhibitory effect of sleep deprivation on cell proliferation in the hippocampus of adult mice is eliminated by corticosterone clamp combined with interleukin-1 receptor 1 knockout. BRAIN BEHAVIOR AND IMMUNITY 2014; 35(-;-):182-188. >>> Corticosterone; PEG 400; ethanol; SC; Mice; 1002; Animal info (male, homozygous IL1RI null, 7-8 weeks old); 5% ethanol used; post op. care (buprenorphine 0.1 mg/kg, metacam 1 mg/kg SQ, ADX rats given saline in water bottles); replacement therapy (adrenalectomy); immunology; sleep deprivation study;.

12631 Cuffe, J.S.M., O'Sullivan, L., Simmons, D.G., Anderson, S.T., Moritz, K.M. Maternal Corticosterone Exposure in the Mouse Has Sex-Specific Effects on Placental Growth and mRNA Expression. Endocrinology 2012; 153(-11-):5500-5511. >>> Corticosterone; SC; Mice; 1003D; Control animals were untreated; animal info (C57BL/6, E12.5).

12559 Hayashi, Y., Ushijima, K., Ando, H., Yanagihara, H., Ishikawa, E., Tsuruoka, S., Sugimoto, K., Fujimura, A. Influence of a Time-Restricted Feeding Schedule on the Daily Rhythm of abcb1a Gene Expression and Its Function in Rat Intestine. Journal of Pharmacology and Experimental Therapeutics 2010; 335(-2-):418-423. >>> Corticosterone; Rat; Animal info (Wistar, male, 6 wks old); replacement therapy (adrenalectomy).

11272 Brem, A.S., Morris, D.J., Ge, Y., Dworkin, L., Tolbert, E., Gong, R.J. Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11 beta-HSD activity. American Journal of Physiology-Renal Physiology 2010; 298(-5-):F1178-F1187. >>> Aldosterone; RU-318; dehydrocorticosterone, 11-; corticosterone; DMSO; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL/6, 20-25 g).

11093 Ackermann, D., Gresko, N., Carrel, M., Loffing-Cueni, D., Habermehl, D., Gomez-Sanchez, C., Rossier, B.C., Loffing, J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American Journal of Physiology-Renal Physiology 2010; 299(-6-):F1473-F1485. >>> Corticosterone; NaCl; SC; Rat; Controls received mp w/ vehicle; animal info (male, Wistar); replacement therapy (adrenalecomy).

10050 Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C.R., Zhou, H., Seibel, M.J. The challenge of continuous exogenous glucocorticoid administration in mice. Steroids 2009; 74(-2-):245-249. >>> Corticosterone; PEG 400; DMSO; SC; Mice; 2004; Controls received mp w/ vehicle; functionality of mp verified by residual volume; comparison of SC injections vs. pellet vs SC mp; animal info (Swiss White, male, CD1. 7-9 wks old).

9635 Byerly, M.S., Simon, J., Lebihan-Duval, E., Duclos, M.J., Cogburn, L.A., Porter, T.E. Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 296(-4-):R1180-R1189. >>> Corticosterone; triiodothyronine; DMSO; propylene glycol; SC; Bird (chicken); 2001; Controls received mp w/ vehicle; animal info (male, 29 days old); 50% DMSO used; 50% propylene glycol used.

9085 Mueller, A.D., Pollock, M.S., Lieblich, S.E., Epp, J.R., Galea, L.A.M., Mistlberger, R.E. Sleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormones. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-5-):R1693-R1703. >>> Corticosterone; PEG 400; SC; Rat; 2ML2; Replacement therapy (adrenalectomy); dose-response (Fig. 6); comparison of oral vs. mp; pumps replaced after 1 week; animal info (male, Long-Evans, 300-400g.; male, Sprague Dawley, 250-300g.);"the method of Cort replacement is crucial for detecting an effect of RSD on cell proliferation."(p. R1700), mp was successful at this.

8086 Maxwell, C.R., Ehrlichman, R.S., Liang, Y.L., Gettes, D.R., Evans, D.L., Kanes, S.J., Abel, T., Karp, J., Siegel, S.J. Corticosterone modulates auditory gating in mouse. Neuropsychopharmacology 2006; 31(-5-):897-903. >>> Corticosterone; PEG 400; SC; Mice; 1002; Controls received mp w/ vehicle; dose-response (fig. 3); comparison of SC pellets vs. mp; animal info (male, C57BL/6J, 10-11 wk. old).

8026 Liu, H.H., Payne, H.R., Wang, B., Brady, S.T. Gender differences in response of hippocampus to chronic glucocorticoid stress: Role of glutamate receptors. Journal of Neuroscience Research 2006; 83(-5-):775-786. >>> Corticosterone; PEG; SC; Mice; 2002; Controls received no treatment; functionality of mp verified by plasma corticosterone levels; animal info (male, female, C57BL/6J, 7 wk old);"Although daily injections do elevate plasma corticosterone chronically, animals experience spikes of corticosterone associated with both handling and injection"(pg. 776).

7642 Ellis, S., Mouihate, A., Pittman, Q.J. Early life immune challenge alters innate immune responses to lipopolysaccharide: implications for host defense as adults. FASEB Journal 2005; 19(-8-):U826-U842. >>> Corticosterone; PEG; IP; Rat; 2001; Replacement therapy (adrenalectomy); no stress (see pg. 4); immunology; post op. care (derapen);"the survival rate of this procedure (ADX + mp) was 100% with animals having normal body temperature within 24 hours after the surgery.".

7457 Nuber, U.A., Kriaucionis, S., Roloff, T.C., Guy, J., Selfridge, J., Steinhoff, C., Schulz, R., Lipkowitz, B., Ropers, H.H., Holmes, M.C., Bird, A. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Human Molecular Genetics 2005; 14(-15-):2247-2256. >>> Corticosterone; DMSO; polypropylene glycol; SC; Mice; Controls received mp w/ vehicle; functionality of mp verified by plasma corticosterone levels; comparison of silastic implants vs. mp; 50% DMSO used; 50% propylene glycol used.

6402 Watanobe, H., Habu, S. Adrenal glucocorticoids do not mediate impaired reproductive function induced by lipopolysaccharide in rats. Neuroendocrinology 2003; 78(-1-):23-28. >>> Corticosterone; PEG 400; SC; Rat; 2ML2; Controls received no mp and saline injection; functionality of mp verified by plasma drug concentrations; replacement therapy (orchidectomy; adrenalectomy); LPS given by injection.

5468 Man, M.S., Young, A.H., McAllister-Williams, R.H. Corticosterone modulation of somatodendritic 5-HT1A receptor function in mice. JOURNAL OF PSYCHOPHARMACOLOGY 2002; 16(-3-):245-252. >>> Corticosterone; PEG; SC; Mice; 2001; Corticosterone plasma levels checked; replacement therapy (adrenalectomy); comparison of SC injections vs mp.

5354 Wang, J., Charboneau, R., Balasubramanian, S., Barke, R.A., Loh, H.H., Roy, S. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. J Leukoc. Biol 2002; 71(-5-):782-790. >>> Corticosterone; PEG 400; SC; Mice; Controls received mp w/ vehicle; functionality of mp verified by corticosterone plasma levels; dose-response (p. 784); immunology;.

5091 Yau, J.L.W., Noble, J., Kenyon, C.J., Hibberd, C., Kotelevtsev, Y., Mullins, J.J., Seckl, J.R. Lack of tissue glucocorticoid reactivation in 11 beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2001; 98(--):4716-4721. >>> Corticosterone; Saline; Ethanol; Radio-isotopes; SC; mice; 2001; brain tissue distribution; Vehicle was 90% saline; 10% ethanol; aging; corticosterone brain distribution.

4600 Sacedón, R, Vicente, A, Varas, A, Jiménez, E, Munoz, J.J, Zapata, A.G  Blood 1999; 94(-8-):2819-2826. >>> Corticosterone; Propylene glycol; NaCl; SC; Rat (pregnant); 2ML4; Controls received sham surgery; functionality of mp verified by corticosterone levels in plasma; replacement therapy (adrenalectomy); teratology;.

15656 Souness, G.W., Morris, D.J. 11a- and 11b- hydroxyprogesterone, potent inhibitors of 11b-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension 1996; 27(-pt 1-):421-425. >>> Progesterone, 11a; Hydroxyprogesterone, 11b; RU-28318; Corticosterone; Propylene glycol; SC; rat; 2002; controls received mp w/vehicle; functionality of mp verified by residual volume; replacement therapy (adrenalectomy); agents infused singly and concomitantly in same pump; cardiovascular.

4245 Souness, G.W., Morris, D.J. 11a- and 11b- hydroxyprogesterone, potent inhibitors of 11b-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension 1996; 27(-pt 1-):421-425. >>> Progesterone, 11a; Hydroxyprogesterone, 11b; RU-28318; Corticosterone; Propylene glycol; SC; rat; 2002; controls received mp w/vehicle; functionality of mp verified by residual volume; replacement therapy (adrenalectomy); agents infused singly and concomitantly in same pump; cardiovascular.

3813 Sainio, E.-L. The role of adrenal hormones in the activation of tryptophan 2,3-dioxygenase by nicotinic acid in rat liver. Meth. Find Exp. Clin. Pharmacol 1997; 19(-7-):465-470. >>> Epinephrine; Corticosterone; Ethanol; NaCl; SC; rat; 2ML1; controls received mp w/vehicle; replacement therapy (adrenalectomy).

3347 Lobo, M.J., Remesar, X., Alemany, M. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Biochem. Molec. Biol. Intl 1993; 29(-2-):349-358. >>> Progesterone; Cortisol; Cortisone; Corticosterone; Dehydroepiandrosterone; Androstenedione, 4-; Androstendiol, 5-; Testosterone; Nortestosterone, 19-; Estradiol, B-; Estrone; Estriol; Deoxycorticosterone; PEG 400; IV (lower cava); rat; 2002; controls received mp with PEG; no stress (see pg. 351); pumps placed into peritoneal cavity and sutured to musculature; surgical wound sprinkled with sulphathiazol.

3276 Miller, A.H., Spencer, R.L., Hassett, J., Kim, C., Rhee, R., Ciurea, D., Dhabhar, F., McEwen, B., Stein, M. Effects of selective type I and II adrenal steroid agonists on immune cell distribution. Endocrinology 1994; 135(-5-):1934-1944. >>> Aldosterone; RU-28362; Corticosterone; Propylene glycol; SC; rat; replacement therapy (adrenalectomy).

3261 DeKrey, G.K., Kerkvliet, N.I. Effects of exogenous corticosterone treatment on alloantigen-specific cytotoxic T lymphocyte activity in mice. J. Pharmacol. Exp. Ther 1995; 273(-2-):823-829. >>> Corticosterone; Dexamethasone; PEG 400; mice; 2002; controls received mp with PEG; functionality of mp verified by plasma levels; immunology; agent infusion delayed 1 day after surgery (by using catheter tubing).

3007 Palmer, L.G., Antonian, L., Frindt, G. Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K. J. Gen. Physiol 1994; 104(--):693-710. >>> Aldosterone; Corticosterone; PEG 300; SC; rat; 2002; replacement therapy (adrenalectomy).

2502 Thordarson, G., Fielder, P., Lee, C., Hom, Y.K., Robleto, D., Ogren, L., Talamantes, F. Mammary gland differentiation in hypophysectomized, pregnant mice treated with corticosterone and thyroxine. Biol. Reprod 1992; 47(--):676-682. >>> Corticosterone; Cyclodextrin; SC; mice (pregnant); 2001; controls received mp w/ vehicle, sham operation or no treatment; vehicle was Molecusol.

2261 Fragman, S., Harnik, M., Peleg, E., Zamir, N., Rosenthal, T. The hypertensinogenic activity of 18,19-dihydroxycorticosterone in adrenalectomized rats. Am. J. Hypertens 1992; 5(--):399-401. >>> Aldosterone; Corticosterone, dihydroxy-; Propylene glycol; SC; rat; 2002; controls received mp w/vehicle; replacement therapy (adrenalectomy).

2028 Petitte, J.N., Etches, R.J. Daily infusion of corticosterone and reproductive function in the domestic hen (Gallus domesticus). Gen. Comp. Endocrinol 1991; 83(-3-):397-405. >>> Corticosterone; PEG 400; SC; bird (chicken); 2ML2; 2ML4; dose-response; pulsed delivery achieved by externalizing PE-60 catheter from pump. Catheter could be disconnected at will for intermittent delivery: 10 hr on/14 hr off, 4 hr on/20 hr off, 24 hr on/0 hr off (pg 398-399).

1845 Brown, G., Douglas, J. Effect of angiotensin II infusion in rats on Na, K-ATPase activity in renal cortical microsomal preparations. Arch. Biochem. Biophys 1989; 275(-1-):236-243. >>> Angiotensin II; Corticosterone; Acetic acid; PEG 400; IP; rat; replacement therapy (adrenalectomy); peptides; multiple pumps per animal (2) placed IP.

1646 Gomez-Sanchez, E.P., Venkataraman, M.T., Thwaites, D., Fort, C. ICV infusion of corticosterone antagonizes ICV-aldosterone hypertension. Am. J. Physiol 1990; 258(-21-):E649-E653. >>> Aldosterone; RU-26988; Corticosterone; CSF, artificial; Propylene glycol; CSF/CNS; rat; 2002; dose-response (graph); pump replaced at 2 weeks; propylene glycol at 2%.

1429 Rosenthal, T., Shani, M., Peleg, E., Harnik, M. The hypertensinogenic activity of 18-hydroxy-19-norcorticosterone in the adrenalectomized rat. Am. J. Hypertens 1988; 1(-3-):49S-51S. >>> Aldosterone, 18-; Hydroxy-19-norcorticosterone; Hydroxycortisone, 18-; Propylene glycol; SC; rat; 2002; hc and aldo administered concomitantly.

1265 Jones, R.B., Beuving, G., Blokhuis, H.J. Tonic immobility and Heterophil/lymphocyte responses of the domestic fowl to corticosterone infusion. Physiol. Behav 1988; 42(-3-):249-253. >>> Corticosterone; PEG 400; SC; bird (chicken); 2ML2; controls received mp w/vehicle; dose-response; functionality of mp verified by previous studies.

1202 Powell, P.C., Davison, T.F. Induction of Marek's disease in vaccinated chickens by treatment with betamethasone or corticosterone. Isr. J. Vet. Med 1986; 42(-2-):73-78. >>> Corticosterone; SC; bird (chicken); Pump model not stated; controls received saline injections; concomitant cyclophosphamide injections; immunology.

15395 John, T.M., Viswanathan, M., Etches, R.J., Pilo, B., George, J.C. Influence of corticosterone infusion on plasma levels of catecholamines, thyroid hormones, and certain metabolites in laying hens. Poult. Sci 1987; 66(-6-):1059-1063. >>> Corticosterone; PEG 400; SC; bird (chicken); Pump model not stated; controls received mp w/ vehicle.

1139 John, T.M., Viswanathan, M., Etches, R.J., Pilo, B., George, J.C. Influence of corticosterone infusion on plasma levels of catecholamines, thyroid hormones, and certain metabolites in laying hens. Poult. Sci 1987; 66(-6-):1059-1063. >>> Corticosterone; PEG 400; SC; bird (chicken); Pump model not stated; controls received mp w/ vehicle.

1003 Mann, D.R., Free, C., Nelson, C., Scott, C., Collins, D.C. Mutually independent effects of adrenocorticotropin on luteinizing hormone and testosterone secretion. Endocrinology 1987; 120(--):1542-1550. >>> ACTH(1-24); Corticosterone; Propylene glycol; Saline; SC; rat; 2001; 2ML1; controls received mp w/vehicle; peptides; replacement therapy (adrenalectomy).

850 McEwen, B.S., Lambdin, L.T., Rainbow, T.C., De Nicola, A.F. Aldosterone effects on salt appetite in adrenalectomized rats. Neuroendocrinology 1986; 43(--):38-43. >>> Aldosterone, d-; RU-28313; Corticosterone; Propylene glycol; SC; rat; 2001; controls received mp w/vehicle; hypertension; 3 doses of aldosterone infused; replacement therapy (adrenalectomy); RU-28313 is an antimineralcorticoid.

731 Devenport, L.D., Goodwin, K.G., Hopkins, P.M. Continuous infusion of aldosterone: correlates of body weight gain. Pharmacol. Biochem. Behav 1985; 22(--):707-709. >>> Corticosterone; PEG; SC; rat; 2002; replacement therapy (adrenalectomy); controls received sham pumps; varied doses of aldosterone administered in combination w/ mp infusion; mp delivery failure? (see pg. 707).

710 Mills, D.E., Woods, R.B. Interaction of prolactin with adrenal hormones in blood pressure regulation in rats. Am. J. Physiol 1985; 249(--):E614-E618. >>> Corticosterone; Epinephrine; Norepinephrine; Prolactin, ovine; Ethanol; Sodium chloride; Water; IP; rat; 2001; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents; multiple pumps per animal (2) for CORT; hypertension; controls received mp w/NaCl; peptides.

709 Fukushima, M., Lupien, J., Bray, G.A. Interaction of light and corticosterone on food intake and brown adipose tissue of the rat. Am. J. Physiol 1985; 249(--):R753-R757. >>> Corticosterone; Propylene glycol; Saline; rat; 2ML2; comparison of ip injection vs. mp infusion; replacement therapy (adrenalectomy); mp functionality (rates) verified in vitro prior to study.

656 van Zon, A.A.J.C., Eling, W.M.C., Schetters, T.P.M., Hermsen, C.C. ACTH-dependent modulation of malaria immunity in mice. Parasite Immunol 1985; 7(-2-):107-117. >>> Cosyntropin; Corticosterone; Dexamethasone; Hank's solution; HEPES solution; PEG; SC; mice; 2002; comparison of agents effects; replacement therapy (adrenalectomy); tetracosactrin (cosyntropin) is a synthetic ACTH analog; dose-response data; immunology.

612 Phillips, R., Crock, C., Funder, J. Effect of mineralocorticoids and glucocorticoids on compensatory adrenal growth in rats. Am. J. Physiol 1985; 248(-4-):E450-E456. >>> Aldosterone; Fluorocortisol acetate, 9a-; Corticosterone; Deoxycorticosterone; Dexamethasone; Ethanol; Propylene glycol; Water; SC; rat; replacement therapy (unilateral adrenalectomy); each mp used twice, 3 days in one animal, then 3 days in another; cannot tell if stability/concentration of ald. determined by RIA before or after exp.

566 Will, P.C., Cortright, R.N., DeLisle, R.C., Douglas, J.G., Hopfer, U. Regulation of amiloride-sensitive electrogenic sodium transport in the rat colon by steroid hormones. Am. J. Physiol 1985; 248(-1-):G124-G132. >>> Aldosterone; Corticosterone; Dexamethasone phosphate; Estradiol, 17B-; Progesterone; Testosterone; PEG 400; PEG 600; IP; rat; 1701; 2001; comparison of agents effects; replacement therapy (adrenalectomy&ovariectomy); controls received mp with solvent or glass rods of mp size; no stress implied G125, weight regained; functionality of mp verified.

61 Will, P.C., Cortright, R.N., Hopfer, U. Polyethylene glycols as solvents in implantable osmotic pumps. J. Pharm. Sci 1980; 69(-6-):747-749. >>> Aldosterone; Corticosterone; Deoxycorticosterone acetate; Dexamethasone acetate; Estradiol, 17B-; Hydrocortisone; Progesterone; Spironolactone; Testosterone; PEG; PEG 400; PEG 600; IP; rat; 1701; 3-7 days aldosterone, 6 days PEG only; replacement therapy (adrenalectomy).

 

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“Several approaches have been tested to improve the anti-tumor activity of cytotoxins and immunotoxins and to decrease toxicity and immunogenicity of these agents.”... “In our current study, we utilized a device for continuous infusion (ALZET pump) of drug as an alternate approach to increase the availability of drug. This approach resulted in improved anti-tumor effect and decreased toxic effects.” “Utilizing this device, IL-13 cytotoxin can be continuously administered systemically in body.” Kawakami et al., Molecular Medicine 2002;8(8):487-494.