References on the Administration of Peptides to the CNS Using ALZET^® Osmotic Pumps

R0247 Fernstrom,J.D., Choi,S. The development of tolerance to drugs that suppress food intake. PHARMACOLOGY&THERAPEUTICS 2008; 117(-1-):105-122. >>> Fenfluramine; leptin; melanotan II; CSF, artificial; PBS; SC; CSF/CNS; Rat; 8 weeks; 7, 28 days; Controls received mp w/ vehicle; dose-response (fig. 5); pumps replaced; tolerance; peptides; animal info (male, obese); endocrinology; review, see p. 108-110.

P9124 Cao,Y., Shumsky,J.S., Sabol,M.A., Kushner,R.A., Strittmatter,S., Hamers,F.P.T., Lee,D.H.S., Rabacchi,S.A., Murray,M. Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat. NEUROREHABILITATION AND NEURAL REPAIR 2008; 22(-3-):262-278. >>> NEP1-40; DMSO; PBS; CSF/CNS (intrathecal); Rat; 2004; ; Controls received mp w/ vehicle; peptides, animal info (female, Sprague Dawley); 2.5% DMSO used; compound is a Nogo-66 receptor antagonist peptide.

P9074 Xue,B.J., Zhao,Y.Z., Johnson,A.K., Hay,M. Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-3-):H1025-H1032. >>> Tempol; estradiol, 17B-; ICI-182780; SC; CSF/CNS; Mice; 1002; ; ALZET brain infusion kit used; peptides; animal info (male, C57BL/6, 12-16 wks old); location of cannula was verified histologically post mortem.

P9053 Kang,Y.M., Ma,Y., Elks,C., Zheng,J.P., Yang,Z.M., Francis,J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappa B. Cardiovascular Research 2008; 79(-4-):671-678. >>> Losartan; SN50; tempol; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 250-275 g.); pumps were primed in 0.9% saline for 24 hours; SN50 is a synthetic protein.

P9013 Ruggieri,MR Sr, Braverman,A.S., D'Andrea,L., Simpkiss,B., Kozin,S.H., Pontari,M.A., Betz,R., Barbe,M.F. Functional reinnervation of the canine bladder after spinal root transection and immediate end-on-end repair. Journal of Neurotrauma 2006; 23(-7-):1125-1136. >>> Brain-derived neurotrophic factor; CSF/CNS (spinal cord, intrathecal); Dog; 2002; 14 days; Controls received mp w/ saline; dose-response; peptides; post io. care (ketoprofen); animal info (female, mongrel hound, 6-12 months old, 18-22 kg., bladder denervation); mp connected to silicone cuff surrounding spinal cord root bundles (2).

P9007 Hillebrand,J.J.G., Kas,M.J.H., Scheurink,A.J.W., van Dijk,G., Adan,R.A.H. AgRP(83-132) and SHU9119 differently affect activity-based anorexia. European Neuropsychopharmacology 2006; 16(-6-):403-412. >>> SHU 9119; agouti-related protein (83-132), human; Saline, sterile, isotonic; CSF/CNS; Rat; 1007D; 4, 6 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; peptides; post op. care (Buprenorphine, temagesic); animal info (female, Wistar wu); melanocortin antagonist.

P9004 Clark,R.S.B., Nathaniel,P.D., Zhang,X.P., Dixon,C.E., Alber,S.M., Watkins,S.C., Melick,J.A., Kochanek,P.M., Graham,S.H. boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. Journal of Cerebral Blood Flow and Metabolism 2007; 27(-2-):316-326. >>> Nerve growth factor; CSF, artificial; albumin, mouse; CSF/CNS (parietal cortex); Rat; 2002; 14 days; Controls received mp w/ vehicle; no stress (see pg. 321); peptides; cardiovascular; animal info (male, Sprague Dawley, 280-400 g., CCI brain injury); behavioral testing (beam balance, beam walking, Morris water maze).

P8999 Sagara,Y., Hirooka,Y., Nozoe,M., Ito,K., Kimura,Y., Sunagawa,K. Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors. Journal of Hypertension 2007; 25(-2-):399-406. >>> Angiotensin II; phenylephrine; Y-27632; valsartan; CSF, artificial; SC; CSF/CNS; Rat; 1002; 2001; 7 days; Controls received mp w/ vehicle; enzyme inhibitor (Rho-kinase); antihypertensive; peptides; animal info (male, Wistar-Kyoto, SHR, 280-340 g.); catheter tip placement and connection confirmed.

P8988 Wachs,F.P., Winner,B., Couillard-Despres,S., Schiller,T., Aigner,R., Winkler,J., Bogdahn,U., Aigner,L. Transforming growth factor-beta 1 is a negative modulator of adult neurogenesis. Journal of Neuropathology and Experimental Neurology 2006; 65(-4-):358-370. >>> Transforming growth factor-B1, recomb.; CSF, artificial; CSF/CNS; Rat; 2002; 7 days; Controls received mp w/ vehicle; peptides; animal info (female, Fischer-344, 2-3 months old, 180 g.).

P8976 Park,S.W., Yan,Y.P., Satriotomo,I., Vemuganti,R., Dempsey,R.J. Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. Journal of Neurosurgery 2007; 107(-3-):593-599. >>> Substance P; L703,606; CSF, artificial; CSF/CNS; Rat; 2001; 5 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; peptides; ischemia (cerebral); animal info (male, SHR, MCAO, 250-350 g.); NK1R antagonist.

P8968 Zeinoaldin,S., Swarts,J.J.M., Van de Heijning,B.J.M. Central application of IGF-1 postpones time of vaginal opening in normally fed, but not in food-restricted rats. Hormone Research 2006; 66(-4-):169-174. >>> Insulin-like growth factor-1, recomb. human; Acetic acid; BSA; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ saline; peptides; animal info (Wistar, female, 23 days old, 45 g.); cannula position confirmed with Evans blue dye post mortem; endocrinology.

P8967 Knight,W.D., Swoap,S.J., Parsons,A.D., Overton,J.M. Central thyrotropin-releasing hormone infusion opposes cardiovascular and metabolic suppression during caloric restriction. Neuroendocrinology 2006; 83(-2-):69-76. >>> Thyrotropin-releasing hormone; PBS; CSF/CNS; Rat; 1002; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 350 g.); behavioral testing (locomotor activity).

P8941 Komatsu,T., Chiba,T., Yamaza,H., To,K., Toyama,H., Higami,Y., Shimokawa,I. Effect of leptin on hypothalamic gene expression in calorie-restricted rats. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2006; 61(-9-):890-898. >>> Leptin, recomb.; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; peptides; animal info (male, Fischer 344, 34 wks old).

P8934 Lu,J., Zhang,Y.D., Shi,J.P. Effects of intracerebroventricular infusion of angiotensin-(1-7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia-reperfusion in rats. Brain Research 2008; 1219(-;-):127-135. >>> Angiotensin (1-7); CSF, artificial; CSF/CNS; Rat; 1007D; ; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; peptide; ischemia (cerebral); animal info (male, Sprague Dawley, 280-300 g.).

P8917 Bartolomucci,A., Rigamonti,A.E., Bulgarelli,I., Torsello,A., Locatelli,V., Pavone,F., Levi,A., Possenti,R., Muller,E.E., Moles,A. Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice. GROWTH HORMONE&IGF RESEARCH 2007; 17(-4-):342-345. >>> TLQP-21, synthetic; CSF, artificial; CSF/CNS; Mice; 1002; 14 days; ALZET brain infusion kit 1 used; peptides; animal info (male, Swiss CD1, 30-35 g.); behavioral testing (grip strength).

P8915 Lujan,M.E., Krzemien,A.A., Reid,R.L., Van Vugt,D.A. Effect of leptin administration on ovulation in food-restricted rhesus monkeys. Neuroendocrinology 2006; 84(-2-):103-114. >>> Leptin, recomb. human; Water, sterile; CSF/CNS; Monkey; 2002; 32 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 2 wks; stress/adverse reaction: (see pg. 104) 1 animal removed from study due to CNS infection at 28 weeks; peptides; animal info (female, Rhesus, 6-10 yrs. old, 5-12 kg.); endocrinology.

P8911 Sibilia,V., Bresciani,E., Lattuada,N., Rapetti,D., Locatelli,V., De Luca,V., Dona,F., Netti,C., Torsello,A., Guidobono,F. Intracerebroventricular acute and chronic administration of oblestatin minimally affect food intake but not weight gain in the rat. Journal of Endocrinological Investigation 2006; 29(-11-):RC31-RC34. >>> Obestatin; Water, distilled; saline, sterile; CSF/CNS; Rat; 2004; 28 days; Half life (p. RC-33) "rapid"; ALZET brain infusion kit used; animal info (male, Sprague Dawley, 7 wks old, 175-200 g.); peptides; obestatin is a 23 amino-acid peptides; Evans blue was injected through the cannula to confirm its position in the ventricle.

P8910 do Carmo,J.M., Hall,J.E., da Silva,A.A. Chronic central leptin infusion restores cardiac sympathetic-vagal balance and baroreflex sensitivity in diabetic rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-5-):H1974-H1981. >>> Leptin; CSF/CNS; Rat; 1007D; 7 days; Peptides; animal info (male, Sprague Dawley, 340-360 g.); tygon tubing used; diabetes.

P8908 Ishigaki,A., Aoki,M., Nagai,M., Warita,H., Kato,S., Kato,M., Nakamura,T., Funakoshi,H., Itoyama,Y. Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model. Journal of Neuropathology and Experimental Neurology 2007; 66(-11-):1037-1044. >>> Hepatocyte growth factor, recomb. human; PBS, sulfoxide; CSF/CNS (intrathecal, subarachnoid space); Rat (transgenic); 2002; 2004; 2, 4 weeks; Controls received mp w/ vehicle; dose-response (fig. 2); peptides; animal info (G93A Tg, 100 and 115 days old); neurodegenerative (ALS); "we examined the effects of continuous intrathecal delivery of human recombinant HGF (hrHGF) into Tg rats using implanted infusion pumps for selective and less invasive supply of HGF to the spinal cord." (p.1038).

P8906 Todd,B.J., Fraley,G.S., Peck,A.C., Schwartz,G.J., Etgen,A.M. Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. Biology of Reproduction 2007; 77(-3-):492-503. >>> JB-1; insulin-like growth factor-1, human; CSF, artificial; CSF/CNS; Rat; 1007D; 2002; 5, 7, 14 days; Controls received mp w/ vehicle; stress/adverse reaction: (see pg. 494) surgery led to a 10-15% loss of presurgical body weight, temporary disruption of estrous cycles; peptides; animal info (female, Sprague Dawley, 170-190 g.); IGF-1 receptor antagonist; cannula placement verified by dye injection at end of experiment; endocrinology.

P8894 Davies,J.E., Tang,X.F., Bournat,J.C., Davies,S.J.A. Decorin promotes plasminogen/plasmin expression within acute spinal cord injuries and by adult microglia in vitro. Journal of Neurotrauma 2006; 23(-3-4-):397-408. >>> Decorin, recomb. human; PBS; CSF/CNS (lesion); Rat; 2001; 8 days; Controls received mp w/ cannula only; peptides; animal info (female, Sprague Dawley, 200-225 g.; SCI); cannula placement confirmed post mortem.

P8882 Rich,N., Reyes,P., Reap,L., Goswami,R., Fraley,G.S. Sex differences in the effect of prepubertal GALP infusion on growth, metabolism and LH secretion. PHYSIOLOGY&BEHAVIOR 2007; 92(-5-):814-823. >>> Galanin-like peptide; Saline; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle; good methods pg. 815; ALZET brain infusion kit used; peptides; animal info (prepubescent, male, female, Long Evans, 45-60g.); 26-gauge cannula used.

P8853 Hook,V.Y.H., Kindy,M., Hook,G. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant beta-secretase site of the amyloid precursor protein. Journal of Biological Chemistry 2008; 283(-12-):7745-7753. >>> CAO74Me; E64d; Saline; Me2SO; CSF/CNS; Mice (transgenic); 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 7747); enzyme inhibitor (cysteine protease); ALZET brain infusion kit 3 used; peptides; animal info (male, London APP, Swedish/London APP; 6, 12 months old); neurodegenerative (Alzheimer's disease); "Animals remained healthy and were observed to have normal eating, body weight, grooming + general appearance during the inhibitor treatment period. Of the 96 animals used in this study, none showed postoperative complications, such as infections; also, none died." (p. 7747).

P8839 Augustine,R.A., Grattan,D.R. Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology 2008; 149(-3-):1049-1055. >>> Prolactin, ovine; CSF, artificial; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (female, Sprague Dawley, 10 wks old, 200-300g., pseudopregnant); endocrinology.

P8829 Zaheer,A., Zaheer,S., Thangavel,R., Wu,Y.H., Sahu,S.K., Yang,B.L. Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage. Brain Research 2008; 1208(-;-):192-203. >>> Amyloid protein, beta (1-42), human; Saline; CSF/CNS; Mice; 2004; 28 days; Controls received mp w/ vehicle; peptides; animal info (C57BL/6, wt, GMF-KO, 5-6 months old); neurodegenerative (Alzheimer's disease).

P8810 Li,L.H., Qin,H.Z., Shi,W.Q., Gao,G.D. Local Nogo-66 administration reduces neuropathic pain after sciatic nerve transection in rat. Neuroscience Letters 2007; 424(-3-):145-148. >>> Glutathione S-transferase; glutathione S-transferase-Nogo-66; CSF/CNS (sciatic nerve); Rat; 2002; 14 days; Controls received mp w/ GST or no treatment; peptides; animal info (male, Sprague Dawley, 240-260g., Sciatic nerve transection); pain; silicon tube used.

P8809 Naef,L., Woodside,B. Prolactin/Leptin interactions in the control of food intake in rats. Endocrinology 2007; 148(-12-):5977-5983. >>> Prolactin, ovine; NaHCO3; HCl; CSF/CNS; Rat; 2001; 2002; 7, 10 days; Controls received mp w/ vehicle; dose-response (Fig. 1); peptides; animal info (female, Wistar, 220-240g.).

P8807 Sato,S., Hanada,R., Kimura,A., Abe,T., Matsumoto,T., Iwasaki,M., Inose,H., Ida,T., Mieda,M., Takeuchi,Y., Fukumoto,S., Fujita,T., Kato,S., Kangawa,K., Kojima,M., Shinomiya,K., Takeda,S. Central control of bone remodeling by neuromedin U. Nature Medicine 2007; 13(-10-):1234-1240. >>> Neuromedin U-23, rat; leptin, human; CSF/CNS; Mice; 28 days; Controls received mp w/ PBS; peptides; animal info (C57BL/6J, wt, LepOb, Nmu -/-, Adrb2 -/-, male, female, 3 months old).

P8803 Pinnock,S.B., Herbert,J. Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone. European Journal of Neuroscience 2008; 27(-10-):2493-2500. >>> Brain-derived neurotrophic factor, recomb. human; PBS; albumin, rat serum; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; stress/adverse reaction: (see pg. 2496) 1 animal died (cause unknown); peptides; animal info (male, Lister-Hooded, 200-250g.); cannula position confirmed post mortem with cresyl violet.

P8800 Park,S., Hong,S.M., Sung,S.R., Jung,H.K. Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling. Endocrinology 2008; 149(-2-):445-454. >>> Leptin, recomb. rat; resistin, recomb. murine; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; replacement therapy (pancreatectomy, 90%); peptides; animal info (male, Sprague Dawley, 220g).

P8797 Lee,M., Kim,A., Conwell,I.M., Hruby,V., Mayorou,A., Cai,M.M., Wardlaw,S.L. Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression. Peptides 2008; 29(-3-):440-447. >>> PG-932; [D-Trp8]-gamma-MSH; Saline; CSF/CNS; Rat; 2001; 1003D; 3, 7 days; 84, 66 hours; Controls received mp w/ vehicle; dose-response (fig 4, pg 445); pumps replaced after 7 days; peptides; animal info (male, Sprague-Dawley, 250-275 grams); agents are melanocortin-3-receptor agonists and antagonists ([D-Trp8]-gamma-MSH and PG-932 respectively).

P8783 Guo,Z.H., Jiang,H.Y., Xu,X.R., Duan,W.Z., Mattson,M.P. Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. Journal of Biological Chemistry 2008; 283(-3-):1754-1763. >>> Leptin; PBS; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; ALZET brain infusion kit 3 used; peptides; animal info (male, C57BL/6, 3 months old); neurodegenerative.

P8775 Roa,J., Vigo,E., Garcia-Galiano,D., Castellano,J.M., Navarro,V.M., Pineda,R., Dieguez,C., Aguilar,E., Pinilla,L., Tena-Sempere,M. Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 294(-6-):E1088-E1096. >>> Kisspeptin-10; Leptin; Saline, physiological; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by response duration and examination; stability verified by persistent FSH response; peptide; animal info (female, Wistar, 205-275 g., adult, 110-120g., 30 days old).

P8760 Yao,F.R., Sumners,C., O'Rourke,S.T., Sun,C.W. Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-6-):H2712-H2720. >>> Angiotensin II; CSF/CNS; Rat; 1002; 2 weeks; Controls received mp w/ physiological saline; cardiovascular; peptides; animal info (male, Sprague Dawley 270-320g).

P8753 Koch,L., Wunderlich,F.T., Seibler,J., Konner,A.C., Hampel,B., Irlenbusch,S., Brabant,G., Kahn,C.R., Schwenk,F., Bruening,J.C. Central insulin action regulates peripheral glucose and fat metabolism in mice. Journal of Clinical Investigation 2008; 118(-6-):2132-2147. >>> Leptin; insulin; SC; CSF/CNS; Mice; 1002; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by serum leptin levels; ALZET brain infusion kit 3 used; peptides; cyanoacrylate adhesive; animal info (C57BL/6, wt, IR-d-wb, 10-14 wks old); cannula position confirmed post mortem with methylene blue.

P8717 Brooks,D.E., Komaromy,A.M., Kallberg,M.E., Miyabashi,T., Ollivier,F.J., Lambrou,G.N. Blood flow velocity response of the ophthalmic artery and anterior optic nerve head capillaries to carbogen gas in the rhesus monkey model of optic nerve head ischemia. VETERINARY OPHTHALMOLOGY 2007; 10(-;-):20-27. >>> Endothelin-1; CSF/CNS (optic nerve); Monkey (Rhesus); 2004; 8 months; Controls received mp w/ vehicle; long-term study; pumps replaced every 4 weeks; peptides; animal info (young, male, Rhesus); glaucoma.

P8705 Mizuno,M., Sotoyama,H., Narita,E., Kawamura,H., Namba,H., Zheng,Y.J., Eda,T., Nawa,H. A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor. Journal of Neuroscience 2007; 27(-38-):10116-10127. >>> Epidermal growth factor, recomb. human; Saline; CSF/CNS (striatum); CSF/CNS (nucleus accumbens); Rat; 2002; 8-14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 1); peptides; multiple pumps per animal (2); post op. care (cefmetazon); animal info (male, Sprague-Dawley, 7-8 wks old, 300-380g); cannula position confirmed after completion of tests.

P8684 Fuezesi,T., Wittmann,G., Liposits,Z., Lechan,R.M., Fekete,C. Contribution of noradrenergic and adrenergic cell groups of the Brainstem and agouti-related protein-synthesizing neurons of the arcuate nucleus to neuropeptide-y innervation of corticotropin-releasing hormone neurons in hypothalamic Paraventricular nucleus of the rat. Endocrinology 2007; 148(-11-):5442-5450. >>> Neuropeptide Y; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; peptides; post op. care (bacitracin ointment over skull); animal info (Sprague-Dawley, male, 280-320g); 22-gauge stainless steel guide cannula, Plastics One.

P8683 Garcia-San Frutos,M., Fernandez-Agullo,T., De Solis,A.J., Andres,A., Arribas,C., Carrascosa,J.M., Ros,M. Impaired central insulin response in aged Wistar rats: Role of adiposity. Endocrinology 2007; 148(-11-):5238-5247. >>> Insulin, human; PBS; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; dose-response (fig. 1, p. 5241); peptides; animal info (Wistar, 3, 8, 24 month, male); endocrinology.

P8681 Grattan,D.R., Jasoni,C.L., Liu,X.H., Anderson,G.M., Herbison,A.E. Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology 2007; 148(-9-):4344-4351. >>> Prolactin, ovine; CSF/CNS; Mice; 1002; 7 days; Serum levels taken, peptides, animal info (adult, female, C57BL6/J, 6-8 weeks, 24-28g, OVX).

P8678 Gallardo,N., Bonzon-Kulichenko,E., Fernandez-Agullo,T., Molto,E., Gomez-Alonso,S., Blanco,P., Carrascosa,J.M., Ros,M., Andres,A. Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology 2007; 148(-12-):5604-5610. >>> Leptin; PBS; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; peptides; animal info (3 months old, Wistar, male); endocrinology.

P8675 Olsson,M., Herrington,M.K., Reidelberger,R.D., Permert,J., Arnelo,U. Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat. Peptides 2007; 28(-7-):1416-1423. >>> Amylin; NaCl; SC; CSF/CNS; CSF/CNS (third ventricle); 2001; 7 days; Dose-response (p. 1418); comparison of ICV infusion vs. mp; peptides; animal info (male, Sprague-Dawley, 310-370g); "Doses in central administration experiments were 10-fold lower than those in the peripheral experiment..." (p. 1417); obesity.

P8672 Popp,E., Schneider,A., Vogel,P., Teschendorf,P., Boettiger,B.W. Time course of the hypothermic response to continuously administered neurotensin. Neuropeptides 2007; 41(-5-):349-354. >>> Neurotensin; Saline; CSF/CNS; Rat; 1003D; ; Controls received mp w/ vehicle; dose-response (pg 351, fig. 1); comparison of SC injections vs. mp; ALZET brain infusion kit 2 used; tolerance; peptides; animal info (Wistar-Han, male, 300-350g); "Diffusion of neurotensin into the pump was avoided by a drop of sesame oil" p. 350; "Complete surgery took about 20 min" p. 350; neurotensin is a tridecapeptide.

P8652 Griffin,R.S., Costigan,M., Brenner,G.J., Ma,C.H.E., Scholz,J., Moss,A., Allchorne,A.J., Stahl,G.L., Woolf,C.J. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. Journal of Neuroscience 2007; 27(-32-):8699-8708. >>> Peptide, C5a receptor antagonist; PBS; CSF/CNS (intrathecal); Rat; 2002; 10 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, C6-deficient, SNI); synthetic, cyclic AcF-[OPdChaWR] peptide.

P8633 Chan,S.H.H., Wang,L.L., Tseng,H.L., Chan,J.Y.H. Upregulation of AT1 receptor gene on activation of protein kinase C beta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla. Journal of Hypertension 2007; 25(-9-):1845-1861. >>> Angiotensin II; CSF, artificial; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; comparison of ICV microinjections vs. mp; cardiovascular; peptides; post op. care (procaine penicillin); animal info (male, Sprague-Dawley, 200-280g).

P8632 Han,G.P., Li,L., Kosugi,I., Kawasaki,H., Tsuchida,T., Miura,K., Tsutsui,Y. Enhancement of susceptibility of adult mouse brain to cytomegalovirus infection by infusion of epidermal growth factor. Journal of Neuroscience Research 2007; 85(-13-):2981-2990. >>> Epidermal growth factor, mouse; PBS; CSF/CNS; Mice; 1003D; 3 days; Controls received mp w/ vehicle; peptides; animal info (female, BALB/c; 10, 25, and 70 wks old).

P8606 Hagg,T., Baker,K.A., Emsley,J.G., Tetzlaff,W. Prolonged local neurotrophin-3 infusion reduces ipsilateral collateral sprouting of spared corticospinal axons in adult rats. Neuroscience 2005; 130(-4-):875-887. >>> Neurotrophin-3, recomb. human; PBS; gentamicin; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 4); stability verified by activity assay of residual mp content after 14 days in vivo; ALZET brain infusion kit used; peptides; post op. care (Penicillin G, buprenorphine); animal info (Sprague-Dawley, 3 months old, 200-220 grams, partial resection of corticospinal tract); schematic of mp p. 877 fig 2.

P8586 Scarpace,P.J., Matheny,M., Zhang,Y., Cheng,K.Y., Tumer,N. Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance. J Pharmacol.Exp.Ther. 2007/2; 320(-2-):706-712. >>> Leptin antagonist; NaHCO3; CSF/CNS; 14 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; peptides; animal info (male, F344xBN, 3 months old, 275-375 grams).

P8560 Plum,L., Rother,E., Muenzberg,H., Wunderlich,F.T., Morgan,D.A., Hampel,B., Shanabrough,M., Janoschek,R., Koenner,A.C., Alber,J., Suzuki,A., Krone,W., Horvath,T.L., Rahmouni,K., Bruening,J.C. Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metabolism 2007; 6(-6-):431-445. >>> Leptin; CSF, artificial; CSF/CNS; Mice; 1002; 2 weeks; Peptides; animal info (male).

P8526 Randolph,C.L., Bierl,M.A., Isaacson,L.G. Regulation of NGF and NT-3 protein expression in peripheral targets by sympathetic input. Brain Research 2007; 1144(--):59-69. >>> Nerve growth factor, mouse; Bisbenzimide; CSF/CNS; Rat; 2002; 2 weeks; Controls received no treatment; peptides; animal info (female, Sprague-Dawley, 3 months old); bisbenzimide (fluorescent marker) added to infusate to monitor cannula placement.

P8505 Yurovsky,V.V., Gerzanich,V., Ivanova,S., Dong,Y., Tsymbalyuk,O., Simard,J.M. Autocrine TGF-beta1 mediates angiotensin II-Induced proliferative response of cerebral vessels in vivo. American Journal of Hypertension 2007; 20(-9-):950-956. >>> Angiotensin II; oligodeoxynucleotide, antisense; Saline; SC; CSF/CNS (intrathecal, cisterna magna); Rat; 2001; 2004; 4-28 days; Controls received mp w/ vehicle; blood pressure taken; antisense (TGF, beta); cardiovascular; peptides; second pump placed IT to deliver ODN.

P8500 Xue,B.J., Pamidimukkala,J., Lubahn,D.B., Hay,M. Estrogen receptor-alpha mediates estrogen protection from angiotensin II- induced hypertension in conscious female. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-4-):H1770-H1776. >>> Angiotensin II; Estradiol, 17B-; ICI-182,780; CSF/CNS; SC; Mice; 1002; ; Blood pressure measured; cardiovascular; ALZET brain infusion kit used; peptides; animal info (OVX, WT, and ER knockout); CNS group delivered E2 + ICI.

P8447 Sheehan,J.J., Zhou,C., Gravanis,I., Rogove,A.D., Wu,Y.P., Bogenhagen,D.F., Tsirka,S.E. Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. Journal of Neuroscience 2007; 27(-7-):1738-1745. >>> Antibody, anti-MCP-1; serum, goat; immunoglobilin G1, mouse; monocyte chemoattractant protein-1 recomb.; antiplasmin, alpha2-; PBS; CSF/CNS (hippocampus); Mice; 1007D; 7 days; Peptides; animal info (C57BL/6, wt, MCP-1 -/-, tPA -/-, plg -/-, 20-25g); neurodegenerative.

P8432 Sonnier,L., Le Pen,G., Hartmann,A., Bizot,J.C., Trovero,F., Krebs,M.O., Prochiantz,A. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. Journal of Neuroscience 2007; 27(-5-):1063-1071. >>> Engrailed2, recomb. chick; Saline; CSF/CNS (substantia nigra); Mice; 1002; 14 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; neurodegenerative (Parkinson's Disease); animal info (Swiss wt, 6-8 weeks old, male).

P8431 Pan,Y.X., Gao,L., Wang,W.Z., Zheng,H., Liu,D.M., Patel,K.P., Zucker,I.H., Wang,W. Exercise training prevents arterial baroreflex dysfunction in rats treated with central angiotensin II. Hypertension 2007; 49(-3-):519-527. >>> Angiotensin II; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ aCSF; cardiovascular; ALZET brain infusion kit II used; peptides; animal info (male, Sprague-Dawley, 300-310g.); cannula placement confirmed with chicago blue dye.

P8331 Joppa,M.A., Gogas,K.R., Foster,A.C., Markison,S. Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice. Peptides 2007; 28(-3-):636-642. >>> Agouti-related peptide (83-132); Saline, sterile; CSF/CNS; Mice; 1003D; 72 hours; Controls received mp w/ vehicle; cancer (colon adenocarcinoma); peptides; animal info (male, BALB/C, 6 weeks old, 22 grams); Research Diets D12689B.

P8322 Sakaguchi,M., Shingo,T., Shimazaki,T., Okano,H.J., Shiwa,M., Ishibashi,S., Oguro,H., Ninomiya,M., Kadoya,T., Horie,H., Shibuya,A., Mizusawa,H., Poirier,F., Nakauchi,H., Sawamoto,K., Okano,H. A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-18-):7112-7117. >>> Antibody, anti-galectin-1; immunoglobulin G, rabbit; Saline; albumin, mouse serum; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle or rabbit IgG; peptides; animal info (male, 1295J wt or galectin-1 -/-, 8 weeks old).

P8319 Burgos-Ramos,E., Hervas-Aguilar,A., Puebla-Jimenez,L., Boyano-Adanez,M.C., rilla-Ferreiro,E. Chronic but not acute intracerebroventricular administration of amyloid beta-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus. Journal of Neuroscience Research 2007; 85(-2-):433-442. >>> Amyloid protein, beta (25-35); amyloid protein, beta (35-25); Acetic acid; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp peptides; animal info (male, Wistar, 200-250 grams); neurodegenerative (Alzheimer's disease).

P8316 Ohta,S., Gregg,C., Weiss,S. Pituitary adenylate cyclase-activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo. Journal of Neuroscience Research 2006; 84(-6-):1177-1186. >>> Pituitary adenylate cyclase-activating polypeptide; Saline; albumin, mouse serum; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; peptides; animal info (CD1, 6-7 wks old).

P8300 Messina,M.M., Overton,J.M. Cardiovascular effects of melanin-concentrating hormone. REGULATORY PEPTIDES 2007; 139(-1-3-):23-30. >>> Melanin-concentrating hormone; PBS; BSA; CSF/CNS; Rat; 1002; 10 days; Controls received mp w/ vehicle; dose-response (fig. 1); comparison of acute icv infusion vs. mp; peptides; post op. care (Bupivacaine); animal info (male, Long-Evans, 330g.).

P8276 Rustamzadeh,E., Hall,W.A., Todhunter,D.A., Vallera,V.D., Low,W.C., Liu,H.Y., Panoskaltsis-Mortari,A., Vallera,D.A. Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice. International Journal of Cancer 2006; 120(-2-):411-419. >>> DTAT; Saline; CSF/CNS; Mice; 1007D; ; Controls received mp w/ vehicle; dose-response (table 1); comparison of bolus ICV injections vs. mp; cancer (glioblastoma); toxicology; peptides; animal info (C57BL/6, female, 12 weeks old); diptheria toxin; "delivery of DTAT resulted in about a 16 fold increase in maximum tolerated dose." (p. 411); "The results of this experiment indicate that the toxicity of uPAR can be reduced by CED (mp) delivery." (p. 416).

P8267 Warner-Schmidt,J.L., Duman,R.S. VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-11-):4647-4652. >>> Vascular endothelial growth Factor 164, recomb. rat; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, 175-200g.).

P8262 Nogueiras,R., Tovar,S., Mitchell,S.E., Barrett,P., Rayner,D.V., Dieguez,C., Williams,L.M. Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis. Journal of Endocrinology 2006; 190(-2-):545-553. >>> Leptin, recomb. human; Saline; CSF/CNS; Rat; 2ML2; 7 days; 24, 48 hours; Controls received mp w/ vehicle; dose-response (fig. 6); peptides; animal info (male, Sprague-Dawley, 8-10 wks old, 300g.); cannula placement confirmed by methylene blue staining; endocrinology.

P8246 Sud,R., Ignatowski,T.A., Lo,C.P.K., Spengler,R.N. Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain. BRAIN BEHAVIOR AND IMMUNITY 2007; 21(-1-):112-124. >>> Tumor necrosis Factor-a, recomb. rat: tumor necrosis factor-a, recomb. rat, heat-inactivated; amitriptyline; CSF, artificial; CSF/CNS; Rat; 8 days; Controls received mp w/ vehicle, or heat-inactivated rr-TNFa; comparison of ip injections vs. mp; peptides; animal info (male, Sprague-Dawley, 300-350g); chronic constriction injury to the right sciatic nerve.

P8217 Castellano,J.M., Navarro,V.M., Fernandez-Fernandez,R., Roa,J., Vigo,E., Pineda,R., Dieguez,C., Aguilar,E., Pinilla,L., Tena-Sempere,M. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006; 55(-9-):2602-2610. >>> Insulin; leptin; Saline; HCI; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle, or nondiabetic; replacement therapy (STZ-induced Diabetes); peptides; animal info (male, Wistar, adult).

P8183 Hill-Pryor,C., Dunbar,J.C. The effect of high fat-induced obesity on cardiovascular and physical activity and opioid responsiveness in conscious rats. Clinical and Experimental Hypertension 2006; 28(-2-):133-145. >>> Funaltrexamine, B-; DAMGO; CSF/CNS; Rat; 2ML4; 2 weeks; Controls received mp w/ aCSF; cardiovascular; peptides; animal info (male, Wistar, 275-300 grams); mu opioid agonist, antagonist.

P8153 Bauer,S., Patterson,P.H. Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. Journal of Neuroscience 2006; 26(-46-):12089-12099. >>> Ara-C; leukemia inhibitory factor, recomb. mouse; epidermal growth factor, recomb. human; Saline; PBS; BSA; CSF/CNS; Mice; 1003D; 1007D; 1, 3, 6, 7, days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 or 3 used; peptides; animal info (adult, male, C57BL/6J, 2-6 months old).

P8149 Kovacs,P., Morales,J.C., Karkanias,G.B. The effect of diabetes and centrally administered insulin on anterior hypothalamic estrogen receptor alpha immunoreactivity. ACTA DIABETOLOGICA 2007; 44(-1-):38-44. >>> Insulin, human; Saline; CSF/CNS (third ventricle); Rat; 2002; 14 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced Diabetes, ovariectomy); peptides; animal info (female, Sprague-Dawley, 175-200g.); tissue perfusion (ventricle).

P8142 Iores-Marcal,L.M., Viel,T.A., Buck,H.S., Nunes,V.A., Gozzo,A.J., Cruz-Silva,I., Miranda,A., Shimamoto,K., Ura,N., Araujo,M.S. Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease. Peptides 2006; 27(-12-):3363-3369. >>> Amyloid protein, beta (1-40), human; E-64; HEPES; E-64; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; animal info (male, Wistar, 3 mo. old); neurodegenerative (Alzheimer's disease); cathepsin B inhibitor.

P8141 Huang,Q.L., Timofeeva,E., Richard,D. Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress. Journal of Endocrinology 2006; 191(-1-):179-188. >>> Leptin, recomb. murine; CSF/CNS (third ventricle); Rat; 2001; 5 days; Controls received mp w/ PBS; peptides; animal info (male, Wistar, 270-290g.); tissue perfusion (ventricle).

P8112 Ji,B., Li,M., Wu,W.T., Yick,L.W., Lee,X., Shao,Z., Wang,J., So,K.F., Mccoy,J.M., Pepinsky,R.B., Mi,S., Relton,J.K. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. MOLECULAR AND CELLULAR NEUROSCIENCE 2006; 33(-3-):311-320. >>> Immunoglobulin G1, human; LINGO-1-Fc, recomb. human; PBS; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle, or IgG1; replacement therapy (dorsal hemisection); peptides; post op. care (Buprenorphine/Buprenex, Ampicillin); animal info (female, Long Evans, 7 wk old).

P8111 Jackson,E.L., Garcia-Verdugo,J.M., Gil-Perotin,S., Roy,M., Quinones-Hinojosa,A., VandenBerg,S., varez-Buylla,A. PDGFR-alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 2006; 51(-2-):187-199. >>> Platelet-derived growth factor-AA; Saline; BSA; CSF/CNS; Mice; 6, 14 days; Controls received mp w/ vehicle; comparison of icv injections vs. mp; peptides; animal info (CD-1, GFAP-Tva, 2-4 months old).

P8106 Liu,D.M., Gao,L., Roy,S.K., Cornish,K.G., Zucker,I.H. Neuronal angiotensin II type 1 receptor upregulation in heart failure - Activation of activator protein 1 and jun N-terminal kinase. Circulation Research 2006; 99(-9-):1004-1011. >>> Angiotensin II; losartan; CSF, artificial; CSF/CNS; Rabbit; 2001; 6 days; Controls received no treatment; cardiovascular; peptides; animal info (male, New Zealand White, 3.2-4.1 kg., CHF).

P8085 Date,I., Takagi,N., Takagi,K., Tanonaka,K., Funakoshi,H., Matsumoto,K., Nakamura,T., Takeo,S. Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels. Neuroscience Letters 2006; 407(-2-):141-145. >>> Hepatocyte growth factor, recomb. human; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ physiological saline; peptides; ischemia (cerebral); animal info (male, Wistar, 180-220g, microsphere-induced cerebral embolism).

P8078 Hoe,H.S., Pociuausek,A., Dai,H.N., Chakraborty,G., Harris,D.C., Rebeck,G.W. Effects of apoE on neuronal signaling and APP processing in rodent brain. Brain Research 2006; 1112(-;-):70-79. >>> Apolipoprotein E; apolipoprotein E3, recomb human; apolipoprotein E4, recomb human; Saline; CSF/CNS (dorsal hippocampus); Rat; 2001; 1 week; Controls received mp w/ vehicle; comparison of icv injections vs. mp; peptides; animal info (Sprague-Dawley, 230-250g.); correct infusion sites confirmed post mortem; tissue perfusion (hippocampus).

P8054 Cifani,C., Guerrini,R., Massi,M., Polidori,C. Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats. Peptides 2006; 27(-11-):2803-2810. >>> Nociceptin/orphanin FQ; Saline; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig.1); peptides; post op.care (benzyl penicillin, dihydrostreptomycin); animal info(Marchigian-Sardinian alcohol-preferring (msp), male, 250-300g.); cannula placement verified with india ink injection at experiment end.

P8040 Zhang,J., Matheny,M.K., Tuemer,N., Mitchell,M.K., Scarpace,P.J. Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2007; 292(-2-):R868-R874. >>> Leptin; leptin antagonist; Sodium bicarbonate; CSF/CNS; 2001; 7 days; Controls received mp w/ vehicle; leptin plasma levels taken; ALZET brain infusion kit used; peptides; animal info (male, Fischer, Brown Norway); dental cement used to secure cannula.

P7974 Bennett,D.L.H., Boucher,T.J., Michael,G.J., Popat,R.J., Malcangio,M., Averill,S.A., Poulsen,K.T., Priestley,J.V., Shelton,D.L., McMahon,S.B. Artemin has potent neurotrophic actions on injured C-fibres. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 2006; 11(-4-):330-345. >>> Artmenin, recomb. human; HEPES-mannitol buffer; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (adult, male, spinal nerve ligation and axotoma); GDNF family factor.

P7973 Bartolomucci,A., La Corte,G., Possenti,R., Locatelli,V., Rigamonti,A.E., Torsello,A., Bresciani,E., Bulgarelli,I., Rizzi,R., Pavone,F., D'Amato,F.R., Severini,C., Mignogna,G., Giorgi,A., Schinina,M.E., Elia,G., Brancia,C., Ferri,G.L., Conti,R., Ciani,B., Pascucci,T., Dell'Omo,G., Muller,E.E., Levi,A., Moles,A. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-39-):14584-14589. >>> TLQP-21, synthetic; CSF, artificial; CSF/CNS; Mice; 1002; 14 days; Controls received mp w/ vehicle; stability verified by HPLC after 14 days at 37 C; ALZET brain infusion kit 1 used; peptides; animal info (male, CD1); obesity.

P7955 Nakagawa,Y., Yuzuriha,T., Iwaki,T. Active clearance of human amyloid beta 1-42 peptide aggregates from the rat ventricular system. NEUROPATHOLOGY 2004; 24(-3-):194-200. >>> Amyloid protein, beta (1-42), human synthetic; PBS; CSF/CNS; Rat; ; Controls received mp w/ vehicle; ALZET brain infusion kit used; brain tissue distribution; toxicology; peptides; neurodegenerative (Alzheimer's disease); animal info (male, Wistar, 200-250 grams); 60 minute infusion by syringe; no ALZET pump used, only brain infusion kit.

P7932 Zeinoaldini,S., Swarts,H.J.M., Van de Heijning,B.J.M. Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat. REGULATORY PEPTIDES 2006; 134(-2-3-):158-163. >>> Growth hormone, recomb. human; immunoglobulin G, goat; growth hormone, anti-rat; Saline, sterile; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; post op. care (analgesia, ibuprofen); animal info (female, Wistar, 45 grams).

P7929 Tuereyen,K., Vemuganti,R., Bowen,K.K., Sailor,K.A., Dempsey,R.J. EGF and FGF-2 infusion increases post-ischemic neural progenitor cell proliferation in the adult rat brain. Neurosurgery 2005; 57(-6-):1254-1262. >>> Endothelial growth factor; fibroblast growth factor-2; CSF, artificial; BSA; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; peptides; ischemia (cerebral); animal info (adult, male, SHR, 250-275 grams); MCAO; 0.1% BSA added.

P7928 Toth,C., Brussee,V., Martinez,J.A., McDonald,D., Zochodne,D.W. Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin. Neuroscience 2006; 139(-2-):429-449. >>> Insulin; Saline; CSF/CNS (intrathecal, lumbar, peroneal nerve); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (adult male, Sprague-Dawley, 250-300 grams); silicone catheters (0.012" x 0.025") used between L6-S1 vertebrae; nerve perfusion chamber used for nerve infusion; nerve injury; India Ink in pumps to verify delivery; behavioral testing.

P7914 Chen,L., Yamada,K., Nabeshima,T., Sokabe,M. Alpha 7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal UP induction in beta-amyloid infused rats. Neuropharmacology 2006; 50(-2-):254-268. >>> Amyloid protein, beta (1-40); amyloid protein, beta (40-1); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 11,14 days; Controls received mp w/ vehicle or reverse AB (40-1); no stress (see pg. 255); peptides; neurodegenerative (Alzheimer's disease); animal info (male, KBL Wistar, 280-300 g., 7 weeks old); 35% acetonitrile used.

P7912 Beraud,E., Viola,A., Regaya,I., Confort-Gouny,S., Siaud,P., Ibarrola,D., Le Fur,Y., Barbaria,J., Pellissier,J.F., Sabatier,J.M., Medina,I., Cozzone,P.J. Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy. Annals of Neurology 2006; 60(-5-):586-596. >>> BgK-F6A; CSF/CNS; Rat; 2001; 2002; 3-5 days; 14-18 days; Controls received mp w/ saline; rats with highest doses of drug had jumping seizures (2 rats), pg. 588; ALZET brain infusion kit 2 used; peptides; animal info (female, Lewis, 6 and 12 wk old).

P7890 Boyadjieva,N., Advis,J.P., Sarkar,D.K. Role of beta-endorphin, corticotropin-releasing hormone, and autonomic nervous system in mediation of the effect of chronic ethanol on natural killer cell cytolytic activity. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 2006; 30(-10-):1761-1767. >>> Endorphin, B; corticotropin releasing hormone; CSF, artificial; CSF/CNS (paraventricular nucleus of hypothalamus); Rat; 2002; 16 hours; Controls received mp w/ vehicle; peptides; animal info (male, Fischer, 160-175g.).

P7888 da Silva,A.A., Tallam,L.S., Liu,J.K., Hall,J.E. Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2006; 291(-5-):R1275-R1282. >>> Leptin; Saline; CSF/CNS; Rat; 2002; 10 days; Controls received IV saline; functionality of mp verified by plasma leptin concentrations; comparison of IV infusion vs. mp; cardiovascular; peptides; animal info (male, Sprague-Dawley, 275-325g.).

P7874 Naert,G., Ixart,G., Tapia-Arancibia,L., Givalois,L. Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats. Neuroscience 2006; 139(-2-):779-789. >>> Brain-derived neurotrophic factor; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle, or no treatment; comparison of acute icv injections vs. mp; no stress (see pg. 782); peptides; animal info (male, Sprague-Dawley, 375g.); mp + tubing primed overnight in 37 celsius saline; telemetric transmitter IP.

P7870 Nakai,S., Matsunaga,W., Ishida,Y., Isobe,K., Shirokawa,T. Effects of BDNF infusion on the axon terminals of locus coeruleus neurons of aging rats. NEUROSCIENCE RESEARCH 2006; 54(-3-):213-219. >>> Brain-derived neurotrophic factor; antibody, anti-BDNF; brain-derived neurotrophic factor, biotin-labeled; immunoglobulin G; PBS; BSA; CSF/CNS (frontal cortex); Rat; 2002; 14 days; Controls received mp w/ vehicle, or IgG; dose-response (fig. 3); ALZET brain infusion kit used; brain tissue distribution; peptides; post op. care (enrofloxacin); animal info (male, F344/N, 13 month old, 19 month old); mp primed 3-6 hours in 37 celsius saline.

P7869 Nagao,M., Wen,T.C., Okamoto,M., Irie,K., Takaku,T., Sakanaka,M. In vivo neuroprotective activity of epopeptide AB against ischemic damage. CYTOTECHNOLOGY 2005; 47(-1-3-):139-144. >>> Epopeptide AB; PBS; BSA; CSF/CNS; Gerbil; 7 days; Controls received mp w/ vehicle; dose-response (fig. 1); peptides; ischemia (cerebral); animal info (male, Mongolian, 70-80g., 12 wk. old); common carotid arteries occluded.

P7861 Ramirez-Castillejo,C., Sanchez-Sanchez,F., ndreu-Agullo,C., Ferron,S.R., roca-Aguilar,J.D., Sanchez,P., Mira,H., Escribano,J., Farinas,I. Pigment epithelium-derived factor is a niche signal for neural stem cell renewal. Nature Neuroscience 2006; 9(-3-):331-339. >>> Pigment epithelium-derived factor; pigment epithelium-derived factor, c-terminal; Saline; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle; peptides; animal info (CD1, adult).

P7846 Niimura,M., Takagi,N., Takagi,K., Funakoshi,H., Nakamura,T., Takeo,S. Effects of hepatocyte growth factor on phosphorylation of extracellular signal-regulated kinase and hippocampal cell death in rats with transient forebrain ischemia. European Journal of Pharmacology 2006; 535(-1-3-):114-124. >>> Hepatocyte growth factor, recomb. human; Saline, physiological; CSF/CNS (hippocampus); Rat; 1003D; 1, 2, 3 days; 0.5, 1, 6 hours; Controls received mp w/ vehicle; dose-response (fig. 2); peptides; ischemia (cerebral); animal info (male, Wistar, 200-250g., transient forebrain ischemia by carotid artery occlusion); mp primed in 37 celsius saline.

P7844 Royo,N.C., Conte,V., Saatman,K.E., Shimizu,S., Belfield,C.M., Soltesz,K.M., Davis,J.E., Fujimoto,S.T., McIntosh,T.K. Hippocampal vulnerability following traumatic brain injury: a potential role for neurotrophin-4/5 in pyramidal cell neuroprotection. European Journal of Neuroscience 2006; 23(-5-):1089-1102. >>> Neurotrophin-4/5; PBS; BSA; CSF/CNS (somatosensory cortex); Rat; 1007D; 1 week; Controls received mp w/ vehicle; no stress (see pg. 1095); stability verified by activity after 14 days in mp at 37 celsius; ALZET brain infusion kit II used; peptides; animal info (male, Sprague-Dawley, 350-400g., traumatic brain injury by lateral fluid percussion); mp primed 18 hours at 37 celsius.

P7831 Windle,R.J., Gamble,L.E., Kershaw,Y.M., Wood,S.A., Lightman,S.L., Ingram,C.D. Gonadal steroid modulation of stress-induced hypothalamo-pituitary-adrenal activity and anxiety behavior: Role of central oxytocin. Endocrinology 2006; 147(-5-):2423-2431. >>> Oxytocin antagonist; oxytocin antagonist, desGly-; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ saline; replacement therapy (ovariectomy); ALZET brain infusion kit used; peptides; animal info (female, Sprague-Dawley, 225-250g.); mp primed overnight in isotonic saline.

P7829 Toth,C., Brussee,V., Zochodne,D.W. Remote neurotrophic support of epidermal nerve fibres in experimental diabetes. Diabetologia 2006; 49(-5-):1081-1088. >>> Insulin; insulin-like growth factor-1; Saline; SC; CSF/CNS (intrathecal, lumbar); Rat; 2002; 1 month; Controls received mp w/ vehicle; replacement therapy (stz-induced diabetes); pumps replaced after 2 weeks; peptides; animal info (male, Sprague-Dawley, 300-350g.); comparison of SC mp vs. IT mp.

P7824 Moriya,R., Sano,H., Umeda,T., Ito,M., Takahashi,Y., Matsuda,M., Ishihara,A., Kanatani,A., Iwaasa,H. RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology 2006; 147(-6-):2916-2922. >>> Peptide, RFamide QREFP43; PBS; BSA; CSF/CNS; Mice; 2004; 4 weeks; 24 days; Controls received mp w/ vehicle; dose-response (fig. 3); pumps replaced after 2 weeks of vehicle alone; ALZET brain infusion kit used; peptides; post op. care (cefamedin alpha); animal info (male, C57BL/6J, 27-30g., 15-wk old); endocrinology.

P7821 Cao,Z.X., Gao,Y., Bryson,J.B., Hou,J.W., Chaudhry,N., Siddiq,M., Martinez,J., Spencer,T., Carmel,J., Hart,R.B., Filbin,M.T. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. Journal of Neuroscience 2006; 26(-20-):5565-5573. >>> Interleukin-6, recomb. rat; Saline; CSF/CNS (intrathecal); Rat; 1002; 2 weeks; 24 hours; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 7); no stress (see pg. 5571); peptides; animal info (female, Long-Evans, pg. 21-pg. 23; bilateral dorsal column lesion, 8wk old); mp primed at least 4 hours at 37 celsius.

P7816 Givalois,L., Naert,G., Tapia-Arancibia,L., Arancibia,S. Involvement of brain-derived neurotrophic factor in the regulation of hypothalamic somatostatin in vivo. Journal of Endocrinology 2006; 188(-3-):425-433. >>> Brain-derived neurotrophic factor, recomb. human; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle, or no treatment; comparison of icv injections vs. mp; peptides; animal info (male, Sprague-Dawley, 260-280g.); mp primed overnight in 37 celsius saline.

P7808 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Morshead,C.M., Fehlings,M.G. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. Journal of Neuroscience 2006; 26(-13-):3377-3389. >>> Fibroblast growth factor, basic; epidermal growth factor; platelet-derived growth factor-AA; CSF, artificial; gentamycin; BSA; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Peptides; animal info (female, Wistar, 250g., spinal cord injury, neural precursor cells transplantation).

P7799 Reimers,D., Herranz,A.S., az-Gil,J.J., Lobo,M.V.T., Paino,C.L., Alonso,R., Asensio,M.J., Gonzalo-Gobernado,R., Bazan,E. Intrastriatal infusion of liver growth factor stimulates dopamine terminal sprouting and partially restores motor function in 6-hydroxydopamine-lesioned rats. JOURNAL OF HISTOCHEMISTRY&CYTOCHEMISTRY 2006; 54(-4-):457-465. >>> Liver growth factor, rat; fibroblast growth factor, rat basic; Saline, physiological; albumin, rat; CSF/CNS (striatum); CSF/CNS; Rat; 2002; ; Controls received mp w/ vehicle, or no treatment; ALZET brain infusion kit used; peptides; neurodegenerative (Parkinson's disease); animal info (female, Sprague-Dawley, 220-250g., 6-OHDA induced lesions).

P7797 Zhuang,Z.Y., Wen,Y.R., Zhang,D.R., Borsello,T., Bonny,C., Strichartz,G.R., Decosterd,I., Ji,R.R. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. Journal of Neuroscience 2006; 26(-13-):3551-3560. >>> Peptide, D-JNK inhibitor 1; CSF/CNS (intrathecal); CSF/CNS (dorsal root ganglion); Rat; 2 weeks; 3 days; Controls received mp w/ vehicle, or control peptide; comparison of IT injections vs. mp; enzyme inhibitor (c-Jun-N-terminal kinase); peptides; animal info (male, Sprague-Dawley, 220-260g., spinal nerve ligation); mp primed 3hrs in saline.

P7781 Grimaldi,P., Rossi,F. Lack of neurogenesis in the adult rat cerebellum after Purkinje cell degeneration and growth factor infusion. European Journal of Neuroscience 2006; 23(-10-):2657-2668. >>> Epidermal growth factor, recomb. human; fibroblast growth factor, basic; fibroblast growth factor 8b, recomb. mouse; Phosphate buffer; CSF/CNS; Rat; 2002; 1, 7, 14 days; Controls received mp w/ vehicle; peptides; animal info (Wistar albino, 200-250g, 2-3 months old).

P7779 Craft,J.M., Watterson,D.M., Van Eldik,L.J. Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia 2006; 53(-5-):484-490. >>> Amyloid protein, beta (1-42), human; HEPES; lipoprotein, human high density; CSF/CNS; Mice; 1002; 2 weeks; 28 days; Controls received mp w/ vehicle; peptides; neurodegenerative (Alzheimer's disease); animal info (C57BL/6, 2-3 months old); mp partially coated with paraffin; HDL reduces AB aggregation.

P7776 Stoyanovitch,A.G., Johnson,M.A., Clifton,D.K., Steiner,R.A., Fraley,G.S. Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes 2005; 54(-8-):2471-2476. >>> Galanin-like peptide; antibody, anti-GALP; immunoglobulin G, goat; CSF, artificaial; CSF/CNS; Rat; 2002; 11 days; Controls received mp w/ vehicle, or IgG; functionality of mp verified; AlZET brain infusion kit 2 used; peptides; animal info (adult, male, Sprague-Dawley, 280-320g.); catheter filled with vehicle to allow 6.5 days delay treatment before agent; cannula placement confirmed.

P7762 Jung,K.H., Chu,K., Lee,S.T., Kim,S.J., Sinn,D.I., Kim,S.U., Kim,M., Roh,J.K. Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Research 2006; 1073(--):190-201. >>> Granulocyte colony-stimulating factor, recomb.; Saline; CSF/CNS; Rat; 2002; 7 days; Controls received mp w/ vehicle; no stress (see pg. 199); peptides; animal info (male, Sprague-Dawley, 220-240g).

P7741 Hoe,H.S., Pocivavsek,A., Chakraborty,G., Fu,Z.Y., Vicini,S., Ehlers,M.D., Rebeck,G.W. Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. Journal of Biological Chemistry 2006; 281(-6-):3425-3431. >>> Peptide, Apo E; CSF/CNS (dorsal hippocampus); Rat; 2001; 1 week; Controls received mp w/ saline; peptides; cannula placement confirmed at dissection.

P7728 Frielingsdorf,H., Thal,L.J., Pizzo,D.P. The septohippocampal cholinergic system and spatial working memory in the Morris water maze. Behavioural Brain Research 2006; 168(-1-):37-46. >>> Nerve growth factor, recomb. human; CSF, artificial; gentamicin; albumin, rat serum; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by residual volume; cannula placement confirmed by cresyl violet staining; peptides; animal info (male, Fisher 344, 13-14 wk. old, medial septum lesion, 400g); mp primed 2 days in 37 Celsius saline.

P7717 Suzuki,R., Tobe,K., Aoyama,M., Sakamoto,K., Ohsugi,M., Kamei,N., Nemoto,S., Inoue,A., Ito,Y., Uchida,S., Hara,K., Yamauchi,T., Kubota,N., Terauchi,Y., Kadowaki,T. Expression of DGAT2 in white adipose tissue is regulated by central leptin action. Journal of Biological Chemistry 2005; 280(-5-):3331-3337. >>> Leptin; Saline; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, C57BL/6, 16-18 wk old).

P7706 Mashiko,S., Ishihara,A., Iwaasa,H., Sano,H., Oda,Z., Ito,J., Yumoto,M., Okawa,M., Suzuki,J., Fukuroda,T., Jitsuoka,M., Morin,N.R., MacNeil,D.J., Van der Ploeg,L.H., Ihara,M., Fukami,T., Kanatani,A. Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp34NPY. Endocrinology 2003/5; 144(-5-):1793-1801. >>> Neuropeptide Y, D-Trp34; PBS; BSA; CSF/CNS; Mice; 2001; 2002; 13-21 days; Controls received mp w/ vehicle; dose-response (fig. 1); pumps replaced after 7-14 days; ALZET Brain Infusion kit used; peptides; post op. care (cefamedin); animal info (C57BL/6J, 9-12 weeks old, male); cannula placement confirmed by Evans blue dye injection.

P7677 Ivanov,A., Gerzanich,V., Ivanova,S., DenHaese,R., Tsymbalyuk,O., Simard,J.M. Adenylate cyclase 5 and Kca1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 570(-1-):73-84. >>> Epidermal growth factor; AG-1478; angiotensin II; iberiotoxin; CSF, artificial; saline; CSF/CNS (intrathecal, cisterna magna); SC; Rat; 2001; 2004; 1,3 days; 4 weeks; Controls received mp w/ aCSF; cardiovascular; peptides; animal info (female, wistar, 275-325 g); angiotensin II disolved in saline and was subcutaneously delivered for 4 weeks using the 2004 model pump; AG-1478 is an EGFR inhibitor.

P7642 Sahu,A., Metlakunta,A.S. Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion. Journal of Neuroendocrinology 2005; 17(-11-):720-726. >>> Leptin, recomb. murine; CSF, artificial; CSF/CNS; Rat; 2002; 9, 23 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; pumps replaced after 7 days; peptides; animal info (male, Sprague-Dawley 250-300 g, adult); all animals received aCSF for 7 days, then agent or vehicle for 2 or 16 days.

P7640 Zhao,L.X., Ma,Q.L., Calon,F., Harris-White,M.E., Yang,F.S., Lim,G.P., Morihara,T., Ubeda,O.J., Ambegaokar,S., Hansen,J.E., Weisbart,R.H., Teter,B., Frautschy,S.A., Cole,G.M. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nature Neuroscience 2006; 9(-2-):234-242. >>> Peptide, PAK18; peptide, PAK18-R192A; CSF, artificial; CSF/CNS; Mice; 1002; 1 month; 2, 15 days; Controls received mp w/ vehicle or control peptide PAK18-R192A; peptides; neurodegenerative (Alzheimer's disease); animal info (B6D2F1, 11 month old, male); p21-activated kinase (PAK) peptide 18 contains PAK inhibitory domain with cell permeant TAT sequence.

P7614 Malhotra,S., Savitz,S.I., Ocava,L., Rosenbaum,D.M. Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack. Journal of Neuroscience Research 2006; 83(-1-):19-27. >>> Erythropoietin receptor, soluble; PBS; BSA; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (male, Wistar, 200-225 g, MCA occlusion).

P7607 Fernandez,A.M., Carro,E.M., Lopez-Lopez,C., Torres-Aleman,I. Insulin-like growth factor I treatment for cerebellar ataxia: Addressing a common pathway in the pathological cascade?. BRAIN RESEARCH REVIEWS 2005; 50(-1-):134-141. >>> Insulin-like growth factor I; SC; CSF/CNS; Rat; mice; 1 month; 2 weeks; Peptides; neurodegenerative (cerebellar ataxia); Review, pg. 138, ref #21; "This long-term delivery system increases therapeutically available IGF-1 at least 30-fold as compared to single subcutaneous injections" (p. 138).

P7606 Kadoya,T., Oyanagi,K., Kawakami,E., Hasegawa,M., Inagaki,Y., Sohma,Y., Horie,H. Oxidized galectin-1 advances the functional recovery after peripheral nerve injury. Neuroscience Letters 2005; 380(-3-):284-288. >>> Galectin-1, recomb. human oxidized; CSF/CNS (sciatic nerve); Rat; 2ML4; 12 weeks; Controls received mp w/ PBS; dose-response (fig. 1); long-term study; no stress (see pg. 285); peptides; animal info (male, adult, Sprague-Dawley); "No rats showed any toxic effects or reaction to the administration of rh GAL-1/Ox." (p. 285).

P7604 Bernier,N.J., Craig,P.M. CRF-related peptides contribute to stress response and regulation of appetite in hypoxic rainbow trout. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2005; 289(-4-):R982-R990. >>> Corticotropin-rel. factor, a helical (9-41); Saline, physiological; NaOH; CSF/CNS; Fish (rainbow trout); 1003D; 8 days; Controls received mp w/ vehicle; no stress (see pg. R984); peptides; animal info (male, female, hypoxia); CRF receptor antagonist; x-ray radiography; mp encased in a layer of dialysis tubing; cannula placement confirm; mp at 14C.

P7592 Imamura,K., Morii,H., Nakadate,K., Yamada,T., Mataga,N., Watanabe,Y., Mori,N. Brain-derived neurotrophic factor enhances expression of superior cervical ganglia clone 10 in lateral geniculate nucleus and visual cortex of developing kittens. European Journal of Neuroscience 2006; 23(-3-):637-648. >>> Brain-derived neurotrophic factor, recomb. human; PBS; BSA; CSF/CNS (visual cortex); Cat (kitten); cat; 2002; 14 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; multiple pumps per animal (2); post op. care (ampicillin sodium).

P7587 Hervas-Aguilar,A., Puebla-Jimenez,L., Burgos-Ramos,E., guado-Llera,D., rilla-Ferreiro,E. Effects of single and continuous administration of amyloid beta-peptide (25-35) on adenylyl cyclase activity and the somatostatinergic system in the rat frontal and parietal cortex. Neuroscience 2005; 135(-1-):181-190. >>> Amyloid protein, beta (25-35); amyloid protein, beta scrambled (35-25); Water, distilled; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle or scrambled AB; comparison of ICV injections vs. mp; peptides; neurodegenerative (Alzheimer's disease) animal info (male, Wistar 200-250 g).

P7560 Lu,X.C.M., Williams,A.J., Wagstaff,J.D., Tortella,F.C., Hartings,J.A. Effects of delayed intrathecal infusion of an NMDA receptor antagonist on ischemic injury and peri-infarct depolarizations. Brain Research 2005; 1056(-2-):200-208. >>> CGX-1007; Saline; CSF/CNS (intrathecal, cisterna magna); Rat; 2001D; 16 hours; Controls received mp w/ vehicle; dose-response (fig. 1); no stress (see pg. 203); dose-dependent paralysis and mortality; peptides; ischemia (cerebral); animal info (male, Sprague-Dawley, 275-350 g); agent also known as Conantokin-G; NMDA receptor antagonist; middle cerebral artery occlusion; stretched PE-10 tubing to a PE-60 connection piece.

P7558 Kelleher,M.O., Myles,L.M., Al-Abri,R.K., Glasby,M.A. The use of ciliary neurotrophic factor to promote recovery after peripheral nerve injury by delivering it at the site of the cell body. Acta Neurochirurgica 2006; 148(-1-):55-61. >>> Ciliary neurotrophic factor; CSF/CNS (intrathecal, subarachnoid space); Sheep; 2ML4; 28 days; Controls received mp w/ physiological saline; no stress (see pg. 57); half-life (pg. 59) 3 minutes in serum; peptides; post op. care (cefuroxime); median nerve transected and repaired; "The adverse cytokine-like side-effects associated with systemic administration of CNTF, namely cough, asthenia, nausea, anorexia and weight loss, aphthous stomatitis and fever were not observed in any of our animals". (pg. 57).

P7518 Wilsey,J., Matheny,M.K., Scarpace,P.J. Oral vanadium enhances the catabolic effects of central leptin in young adult rats. Endocrinology 2006; 147(-1-):493-501. >>> Leptin; CSF, artificial; CSF/CNS; Rat; 2004; 21, 28 days; Controls received mp w/ vehicle; dose-response (fig. 7); ALZET brain infusion kit used; peptides; animal info (F344, brown Norway, male, 3 months old, 357-370 g); mp primed 36 hours in 37 C sterile saline.

P7494 Bariohay,B., Lebrun,B., Moyse,E., Jean,A. Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology 2005; 146(-12-):5612-5620. >>> Brain-derived neurotrophic factor, recomb. human; CSF, artificial; CSF/CNS (dorsal vagal complex); Rat; 1002; 15 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 2); brain tissue distribution; peptides; animal info (male, Wistar, 290 g); cannula placement verified with pontamine blue dye.

P7482 Gao,L., Wang,W., Li,Y.L., Schultz,H.D., Liu,D.M., Cornish,K.G., Zucker,I.H. Simvastatin therapy normalizes sympathetic neural control in experimental heart failure roles of angiotensin II type 1 receptors and NAD(P)H oxidase. Circulation 2005; 112(-12-):1763-1770. >>> Angiotensin II; CSF, artificial; CSF/CNS; Rabbit; 2001; 7 days; Cardiovascular; peptides; animal info (male, New Zealand White, 3.2-4.1 kg); chronic heart failure.

P7480 Craft,J.M., Watterson,D.M., Marks,A., Van Eldik,L.J. Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid. Glia 2005; 51(-3-):209-216. >>> Amyloid protein, beta (1-42), human oligomeric; HEPES buffer; lipoprotein, high density; CSF/CNS; Mice (transgenic); 1002; 28 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; brain tissue distribution; peptides; neurodegenerative (Alzheimer's disease); mp partially coated with paraffin to reduce infusion rate and extend duration.

P7472 Nakagawa,Y., Kawashima,T., Yamada,T., Harano,M., Monji,A., Yuzuriha,T., Iwaki,T. Aluminum chloride does not facilitate deposition of human synthetic amyloid beta1-42 peptide in the rat ventricular system of a short-term infusion model. NEUROPATHOLOGY 2005; 25(-3-):195-200. >>> Amyloid protein, beta (1-42), human; PBS; CSF/CNS; Rat; 1 hour; Controls received vehicle, or Tris; no stress (see pg. 197); ALZET brain infusion kit used; toxicology; peptides; neurodegenerative (Alzheimer's disease); animal info (male, Wistar); no mp used, 60 minute infusion of 100ul by pumping a disposable syringe; co-infused with Alcl3.

P7470 Plantman,S., Novikova,L., Novikov,L., Hammarberg,H., Wallquist,W., Kellerth,J.O., Cullheim,S. Integrin messenger RNAs in the red nucleus after axotomy and neurotrophic administration. NeuroReport 2005; 16(-7-):709-713. >>> Brain-derived neurotrophic factor, recomb human; NT-3; CSF/CNS (intrathecal, subarachnoid space); Rat; 1, 3 weeks; Controls recieved no treatment; peptides; animal info (female, Sprague-Dawley); spinal hemisection (peripheral axotomy).

P7451 Fekete,C., Singru,P.S., Sanchez,E., Sarkar,S., Christoffolete,M.A., Riberio,R.S., Rand,W.M., Emerson,C.H., Bianco,A.C., Lechan,R.M. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 2006; 147(-1-):520-529. >>> Leptin, recomb. mouse; insulin; glucose; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; functionality of mp verified by agent levels in CSF+ serum; peptides; post op. care (bacitracin ointment); animal info (male Sprague-Dawley, 200-250 g); cannula placement confirmed by light microscope.

P7449 Li,S.L., Saragovi,H.U., Nedev,H., Zhao,C.N., Racine,R.J., Fahnestock,M. Differential actions of nerve growth factor receptors TrkA and p75(NTR) in a rat model of epileptogenesis. MOLECULAR AND CELLULAR NEUROSCIENCE 2005; 29(-2-):162-172. >>> Peptides, NGF mimics; antibody, anti-NGF monoclonal, NGF30; immunoglobulin G; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or control peptide or IgG; peptides; post op. care (penicillin, apo-sulfatrim); animal info (male Long-Evans, hooded); cannula placement verified with cresyl violet staining; peptides: c25-35, c30-35, c92-92, ss51 (control).

P7316 Dokur,M., Chen,C.P., Advis,J.P., Sarkar,D.K. Beta-endorphin modulation of interferon-gamma, perforin and granzyme B levels in splenic NK cells: Effects of ethanol. Journal of Neuroimmunology 2005; 166(-1-2-):29-38. >>> Endorphin, B-; CSF/CNS (paraventricular nucleus); Rat; 2002; 18 hours; Controls received mp w/ aCSF; immunology; peptides.

P7308 Xie,Z., Harris-White,M.E., Wals,P.A., Frautschy,S.A., Finch,C.E., Morgan,T.E. Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. Journal of Neurochemistry 2005; 93(-4-):1038-1046. >>> Apolipoprotein J, human; Liposome, DMPC; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; peptides; Agent also known as clusterin and SGP-2; neurodegenerative (alzheimer's disease).

P7289 Pereira,P.A., Cardoso,A., Paula-Barbosa,M.M. Nerve growth factor restores the expression of vasopressin and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of aged rats. Brain Research 2005; 1048(-1-2-):123-130. >>> Nerve growth factor; dye, methylene blue; CSF/CNS; Rat; 2002; 14 days; Functionality of mp verified by pretesting delivery rate; ALZET brain infusion kit used; peptides; post op. care (SC saline, local antiseptic); mp filled with Methylene blue, air-oil spacer at tubing connection, tubing filled with NGF; Lynch coil; "Because there is evidence that the surgical procedure does not interfere with the structure of SCN, vehicle - treated rats were not included in this study." (p. 124).

P7288 Scholz,J., Broom,D.C., Youn,D.H., Mills,C.D., Kohno,T., Suter,M.R., Moore,K.A., Decosterd,I., Coggeshall,R.E., Woolf,C.J. Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. Journal of Neuroscience 2005; 25(-32-):7317-7323. >>> zVAD; MK-801; CSF/CNS (intrathecal); Rat; 4 weeks; 7, 14 days; Controls received mp w/ vehicle; comparison of intrathecal injections vs. mp; enzyme inhibitor (caspase); peptides; MK-801also known as dizocilpine; catheter tip location confirmed at end of infusion.

P7285 Dai,Y., Wang,H., Ogawa,A., Yamanaka,H., Obata,K., Tokunaga,A., Noguchi,K. Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy. European Journal of Neuroscience 2005; 21(-9-):2467-2474. >>> KN93; KN92; MK-801; DMSO; saline; CSF/CNS (intrathecal); Rat; 1003D; 2001; 2002; 3,7,14 days; Controls received mp w/ vehicle, or KN92 control peptide; no stress (see pg. 2472); enzyme inhibitor (Ca/Calmodulin - dependent protein Kinase II); peptides; 10% DMSO; cannula tip location verified by dissection; NMDA receptor antagonist.

P7257 Koyama,Y., Tsujikawa,K., Matsuda,T., Baba,A. Endothelin increases expression of exon III-and exon IV-containing brain-derived neurotrophic factor transcripts in cultured astrocytes and rat brain. Journal of Neuroscience Research 2005; 80(-6-):809-816. >>> Endothelin-1; Ala-1, 3, 5, 15-; CSF, artificial; CSF/CNS; Rat; 2002; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; peptides; endothelin B receptor agonist.

P7245 Mashiko,S., Ishihara,A., Gomori,A., Moriya,R., Ito,M., Iwaasa,H., Matsuda,M., Feng,Y., Shen,Z., Marsh,D.J., Bednarek,M.A., MacNeil,D.J., Kanatani,A. Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. Endocrinology 2005; 146(-7-):3080-3086. >>> Melanin-concentrating hormone 1 receptor antagonist; Propylene glycol; CSF, artificial; CSF/CNS; CSF/CNS (third ventricle); Mice; 1007D; 2002; 2004; 3, 8 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced after 1 or 4 weeks of vehicle; ALZET brain infusion kit used; peptides; cyanoacrylate adhesive; post op. care (cefamedin); DEXA; cannula placement confirmed by Evans blue dye injection; animal info (C57BL/6); pumps used in lateral ventricle for one group of animals, and third ventricle for others. Third ventricle group used Plastics One cannulae.

P7229 Gao,L., Wang,W., Li,Y.L., Schultz,H.D., Liu,D.M., Cornish,K.G., Zucker,I.H. Sympathoexcitation by central ANG II: Roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-5-):H2271-H2279. >>> Angiotensin II; losartan; Saline, isotonic; CSF/CNS; Rabbit; 2001; 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; cyanoacrylate adhesive; cannula position verified by Evans blue dye.

P7222 Kim,Y.W., Choi,D.W., Park,Y.H., Huh,J.Y., Won,K.C., Choi,K.H., Park,S.Y., Kim,J.Y., Lee,S.K. Leptin-like effects of MTII are augmented in MSG-obese rats. REGULATORY PEPTIDES 2005; 127(-1-3-):63-70. >>> MT II; CSF/CNS; Rat; 2001; 1 week; Controls received mp w/ aCSF; ALZET brain infusion kit used; peptides; melanocortin receptor 3/4 agonist.

P7215 Michalkiewicz,M., Zhao,G.Q., Jia,Z., Michalkiewicz,T., Racadio,M.J. Central neuropeptide Y signaling ameliorates N omega-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism. Hypertension 2005; 45(-4-):780-785. >>> Neuropeptide Y, synthetic rat; BIBP3226; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; cardiovascular; antihypertensive; peptides; cannula placement confirmed by methylene blue staining; "This approach (mp) allowed us to assess the role of endogenous NPY in long-term control of BP under experimental conditions that excluded complications associated with anesthesia, restraint, and short-term drug administration." (p. 782); neuropeptide Y, Y1 receptor antagonist.

P7214 Nakajima,T., Takauchi,S., Ohara,K., Kokai,M., Nishii,R., Maeda,S., Takanaga,A., Tanaka,T., Takeda,M., Seki,M., Morita,Y. Alpha-Synuclein-positive structures induced in leupeptin-infused rats. Brain Research 2005; 1040(-1-2-):73-80. >>> Leupeptin; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (protease); peptides; "The leupeptin infusion rat model is thought to be a useful material for studying several neuronal changes resembling the aging or degeneration of the central nervous tissue." (p. 79).

P7212 Radecki,D.T., Brown,L.M., Martinez,J., Teyler,T.J. BDNF protects against stress-induced impairments in spatial learning and memory and LTP. Hippocampus 2005; 15(-2-):246-253. >>> Brain-derived neurotrophic factor, recomb. human; CSF/CNS (hippocampus); Rat; 2002; 14 days; Controls received mp w/ vehicle, or PBS or no treatment; functionality of mp verified by residual volume; no stress (see pg. 248); brain tissue distribution; peptides; cyanoacrylate adhesive; "Direct hippocampal infusion was used in our studies to maximize the targeting of BDNF within the hippocampus." (p. 251) Memory study.

P7196 Ogawa,A., Dai,Y., Yamanaka,H., Iwata,K., Niwa,H., Noguchi,K. Ca2+/calmodulin-protein kinase II alpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection. Experimental Neurology 2005; 192(-2-):310-319. >>> KN-93; KN-92; DMSO; CSF/CNS (medulla); Rat; 2001; 7 days; Controls received mp w/ KN-92; enzyme inhibitor (calcium-calmodulin protein kinase II); peptides; cannula placement confirmed by dissection.

P7190 Holmberg,J., Armulik,A., Senti,K.A., Edoff,K., Spalding,K., Momma,S., Cassidy,R., Flanagan,J.G., Frisen,J. Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. GENES&DEVELOPMENT 2005; 19(-4-):462-471. >>> Ephrin-A2-Fc; Ephrin-B2-Fc; EphA7-Fc; Immunoglobulin G, goat anti-human; Ephrin-B1-Fc; PBS; CSF/CNS; Mice; 1007D; 3 days; Controls received mp w/ Fc; peptides; animal info (adult,male, C57BL/6).

P7140 Canudas,A.M., Pezzi,S., Canals,J.M., Pallas,M., Alberich,J. Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury. MOLECULAR BRAIN RESEARCH 2005; 134(-1-):147-154. >>> TrKB-IgG; immunoglobulin G, human; CSF/CNS (substantia nigra); Rat; 1002; 2-72 hours; Controls received mp w/ human IgG; peptides; mp filled with PBS connected to 10 cm of tubing filled with agent; mp primed 4 hours at 37 degrees celsius.

P7102 Nogueiras,R., Barreiro,M.L., Caminos,J.E., Gaytan,F., Suominen,J.S., Navarro,V.M., Casanueva,F.F., Aguilar,E., Toppar,J., Dieguez,C., Tena-Sempere,M. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. Journal of Cell Science 2004; 117(-15-):3247-3257. >>> Leptin, recomb. human; CSF/CNS; Rat; 7 days; Controls received mp w/ vehicle; peptides.

P7071 Hao,J., de Vaca,S.C., Carr,K.D. Effects of chronic ICV leptin infusion on motor-activating effects of D-amphetamine in food-restricted and ad libitum fed rats. PHYSIOLOGY&BEHAVIOR 2004; 83(-3-):377-381. >>> Leptin, recomb. mouse; Saline, sterile; BSA; CSF/CNS; Rat; 2002; 12,14 days; Controls received mp w/ vehicle; peptides.

P7068 Harris-White,M.E., Balverde,Z., Lim,G.P., Kim,P., Miller,S.A., Hammer,H. Role of LRP in TGFbeta2-mediated neuronal uptake of A beta and effects on memory. Journal of Neuroscience Research 2004; 77(-2-):217-228. >>> Amyloid protein, beta; transforming growth factor-B2; receptor-associated protein; HEPES buffer; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; stability verified by incubation at 37 degree Celsius for 2,4 weeks; peptides; RAP is a LRP (lipoprotein receptor-related protein) antagonist; memory.

P7017 Choi,Y.H., la-Fera,M.A., Li,C.L., Hartzell,D.L., Little,D.E., Kuhar,M.J., Balle,C.A. CART peptide: central mediator of leptin-induced adipose tissue apoptosis?. REGULATORY PEPTIDES 2004; 121(-1-3-):155-162. >>> CART (55-102); leptin, recomb. rat; CSF, artificial; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; dose-response; peptides; mp primed overnight; catheter connecting mp to cannula filled with 12 ul aCSF to give 24 hours lag time before agent delivery.

P6996 Bruno,M.A., Clarke,P.B.S., Seltzer,A., Quirion,R.M., Burgess,K., Cuello,A.C., Saragovi,H.U. Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA. Journal of Neuroscience 2004; 24(-37-):8009-8018. >>> Nerve growth factor; D3; dye, methylene blue; CSF, artificial, buffered; saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by infusion volume (pg. 8011); no stress (see pg. 8012); ALZET brain infusion kit used; peptides; used air-oil spacer in PE tubing at pump end, PE tubing used in coil for D3 mp filled with dye; D3 is a peptidomimetic which binds TrKA.

P6989 Enwere,E., Shingo,T., Gregg,C., Fujikawa,H., Ohta,S., Weiss,S. Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. Journal of Neuroscience 2004; 24(-38-):8354-8365. >>> Epidermal growth factor, human recomb.; Ara-C; Saline; albumin, mouse serum; CSF/CNS; Mice; 1003D; 3 days; Controls received mp w/ vehicle; peptides.

P6966 Hashimoto,M., Tanabe,Y., Fujii,Y., Kikuta,T., Shibata,H., Shido,O. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. Journal of Nutrition 2005; 135(-3-):549-555. >>> Amyloid protein, beta (1-40); CSF/CNS; Rat; 2002; ; Peptides; neurodegenerative (Alzheimer's disease); memory; behavioral study.

P6960 McAlister,E.D., Van Vugt,D.A. Effect of leptin administration versus re-feeding on hypothalamic neuropeptide gene expression in fasted male rats. Canadian Journal of Physiology and Pharmacology 2004; 82(-12-):1128-1134. >>> Leptin, recomb. murine; CSF, artificial; SC; CSF/CNS; Rat; 2001; ; Peptides; ICV cannulation performed one week prior to pump implantation.

P6952 Henry,M., Ghibaudi,L., Gao,J., Hwa,J.J. Energy metabolic profile of mice after chronic activation of central NPY Y1, Y2, or Y5 receptors. Obesity Research 2005; 13(-1-):36-47. >>> Neuropeptide Y; Y1 agonist; Y5 agonist; Saline; water; ascorbic acid; CSF/CNS; Mice; 2001; 6 days; Controls received mp w/ vehicle; peptides; mice received a two week recovery period; guide cannula used and secured with tissue adhesive; animal info (6 week old, C57BL/6, 25-30 grams).

P6948 Kim,M.S., Namkoong,C., Kim,H.S., Jang,P.G., Pak,Y.M.K., Katakami,H., Park,J.Y., Lee,K.U. Chronic central administration of ghrelin reverses the effects of leptin. International Journal of Obesity 2004; 28(-10-):1264-1271. >>> Leptin; ghrelin; Saline; CSF/CNS (third ventricle); Rat; 7 days; Controls received mp w/ vehicle; plasma levels; peptides; Plastics One cannula used; 7 day recovery from cannulation prior to pump implant; cannulation verified by dipsogenic response to ICV administration of angiotensin II (150 ng/rat), positive response was defined as the consumption of 5 ml of water within 1 hr of injection.

P6903 Nyberg,J., Anderson,M.F., Meister,B., Alborn,A.M., Stroem,A.K., Brederlau,A., Illerskog,A.C., Nilsson,O., Kieffer,T.J., Hietala,M.A., Ricksten,A., Eriksson,P.S. Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation. Journal of Neuroscience 2005; 25(-7-):1816-1825. >>> Glucose-dependent insulinotropic polypeptide; PBS; CSF/CNS (third ventricle); Rat; 2001; 5 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2; peptides; GIP.

P6890 Liu,I.Y.C., Lyons,W.E., Mamounas,L.A., Thompson,R.F. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. Journal of Neuroscience 2004; 24(-36-):7958-7963. >>> Brain-derived neurotrophic factor, recomb. human; CSF, artificial; CSF/CNS (hippocampus); Mice; 1007D; 2 weeks; Controls received mp w/ vehicle; replacement therapy (BDNF knockout mice); dose-response (fig. 7); pumps replaced at the end of the 1st week; no stress (see pg. 7960); brain tissue distribution; peptides; multiple pumps per animal (2); "all mice appeared well groomed and healthy and exhibited no abnormal behaviors in their home cage." (p. 7960).

P6887 Porter,J.P., Potratz,K.R. Effect of intracerebroventricular angiotensin II on body weight and food intake in adult rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2004; 287(-2-):R422-R428. >>> Angiotensin II; CSF/CNS; Rat; 2002; 2,5,11 days; Controls received mp w/ sterile saline; ALZET brain infusion kit 2 used; peptides; cyanoacrylate adhesive; ICV infusion of ANG II was delayed 2 days after surgery by prefilling the catheter between the mp and the cannula with saline instead of ANG II.

P6882 Craft,J.M., Watterson,D.M., Frautschy,S.A., Van Eldik,L.J. Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. NEUROBIOLOGY OF AGING 2004; 25(-10-):1283-1292. >>> Amyloid protein, beta (1-42), human; HEPES buffer; lipoprotein, high density; CSF/CNS; Mice; 1002; 28 days; Controls received mp w/ vehicle; peptides; mp partially coated with paraffin wax to reduce infusion rate; HDL used to reduce amyloid-beta aggregation; Plastics One cannula used; neurodegenerative disease (Alzheimer's).

P6843 Zimmerman,M.C., Lazartigues,E., Sharma,R.V., Davisson,R.L. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circulation Research 2004; 95(-2-):210-216. >>> Angiotensin II; losartan; SC; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/ saline; cardiovascular; peptides; multiple pumps per animal (2); AT1 receptor antagonists.

P6822 Lee,J.K., Kim,J.E., Sivula,M., Strittmatter,S.M. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. Journal of Neuroscience 2004; 24(-27-):6209-6217. >>> Antibody, NgR (310) Ecto-Fc; Immunoglobulin G, rat; PBS; CSF/CNS; Rat; 2ML4; 9 weeks; Controls received mp w/ rat IgG; long-term study; pumps replaced after 28 days; good methods (p. 6210); ALZET brain infusion kit 2 used; peptides; cyanoacrylate adhesive; ischemia (cerebral); Nogo-Nogo receptor (NgR); NgR (310) Ecto-Fc is an IgG fusion protein with a soluble ectodomain fragment of NgG; behavioral study.

P6821 Li,S.X., Liu,B.P., Budel,S., Li,M.W., Ji,B.X., Walus,L., Li,W.W., Jirik,A., Rabacchi,S., Choi,E., Worley,D., Sah,D.W.Y., Pepinsky,B., Lee,D., Relton,J., Strittmatter,S.M. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. Journal of Neuroscience 2004; 24(-46-):10511-10520. >>> NgR (310) Ecto-Fc; immunoglobulin G, rat; PBS; CSF/CNS (intrathecal); Rat; 2ML4; 4 weeks; Controls received mp w/ rat IgG; peptides.

P6788 Wiksten,M., Vaeaenaenen,A.J., Liebkind,R., Liesi,P. Regeneration of adult rat spinal cord is promoted by the soluble KDI domain of gamma 1 laminin. Journal of Neuroscience Research 2004; 78(-3-):403-410. >>> Laminin, gamma 1-KDI domain; Saline; serum, human; CSF/CNS (intrathecal, spinal cord); Rat; 2ML4; 28 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; post op. care (morphine, ketoprofen).

P6770 Canals,J.M., Pineda,J.R., Torres-Peraza,J.F., Bosch,M., Martin-Ibanez,R., Munoz,M.T., Mengod,G., Ernfors,P., Alberch,J. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. Journal of Neuroscience 2004; 24(-35-):7727-7739. >>> Brain-derived neurotrophic factor; PBS; CSF/CNS (striatum); Mice (transgenic); 2001; 1 week; Controls received mp w/ vehicle; peptides; neurodegenerative (Huntington's disease).

P6768 Tanaka,H., Yamashita,T., Yachi,K., Fujiwara,T., Yoshikawa,H., Tohyama,M. Cytoplasmic p21Cip1/WAF1 enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 2004; 127(-1-):155-164. >>> p21-Cip1/WAF-1, TAT fusion protein, cytoplasmic-; Y-27632; HA-1077; PBS; CSF/CNS (spinal cord, intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle or control protein; functionality of mp verified by BDA-labeled fibers; dose-response (Fig.2); enzyme inhibitor (Rho kinase); peptides.

P6761 McCallister,W.V., McCallister,E.L., Dubois,B., Trumble,T.E. Regeneration along intact nerves using nerve growth factor and ciliary neurotrophic factor. Journal of Reconstructive Microsurgery 2004; 20(-6-):473-481. >>> Nerve growth factor; ciliary neurotrophic factor; CSF/CNS (peroneal nerve); Rat; 2ML4; 28 days; Controls received mp w/ isotonic saline; peptides; mp primed 24 hours in 37 degrees Celsius saline.

P6697 Maher,C.O., Anderson,R.E., Martin,H.S., McClelland,R.L., Meyer,F.B. Interleukin-1beta; and adverse effects on cerebral blood flow during long-term global hypoperfusion. Journal of Neurosurgery 2003; 99(-5-):907-912. >>> Interleukin-1, beta; interleukin-1, receptor antagonist; Saline; CSF/CNS; Rat; 2004; 2,4 weeks; Controls received mp w/ vehicle; no stress (see pg. 909); ALZET brain infusion kit used; peptides; "The use of an osmotic minipump allows for a theoretically continuous infusion over the 2 or 4 week interval and allows agent to acheive a steady state concentration in the CSF." (p. 909).

P6678 Figlewicz,D.P., Bennett,J., Evans,S.B., Kaiyala,K., Sipols,A.J., Benoit,S.C. Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. Behavioral Neuroscience 2004; 118(-3-):479-487. >>> Leptin; insulin; CSF; CSF/CNS (third ventricle); Rat; 7,14 days; Controls received mp w/ vehicle; peptides; behavioral study; one week and two week pump used; models not listed.

P6643 Reyes,A.E., Chacon,M.A., Dinamarca,M.C., Cerpa,W., Morgan,C., Inestrosa,N.C. Acetylcholinesterase-A beta complexes are more toxic than A beta fibrils in rat hippocampus - Effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. American Journal of Pathology 2004; 164(-6-):2163-2174. >>> Amyloid protein, beta (1-40); acetylcholinesterase; PBS; CSF/CNS (dorsal hippocampus); Rat; 2002; 4 weeks; 14 days; Comparison of acute injections vs. mp; brain tissue distribution; peptides.

P6641 Figlewicz,D.P., Zavosh,A., Sexton,T., Neumaier,J.F. Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous "tub" expression. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004; 286(-6-):E1004-E1010. >>> Insulin; CSF, artificial; CSF/CNS (arcuate nucleus); Rat; 1007D; 6 days; Controls received mp w/ vehicle; dose-response (fig. 4); peptides; multiple pumps per animal (2).

P6635 Barton,M.E., White,H.S. The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression. Epilepsy Research 2004; 59(-1-):1-12. >>> CGX-1007; CSF, artificial; CSF/CNS (amygdala); Rat; 9 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; peptides; CGX-1007 is a polypeptide NMDA receptor antagonist.

P6634 Croll,S.D., Ransohoff,R.M., Cai,N., Zhang,Q., Martin,F.J., Wei,T., Kasselman,L.J., Kintner,J., Murphy,A.J., Yancopoulos,G.D., Wiegand,S.J. VEGF-mediated inflammation precedes angiogenesis in adult brain. Experimental Neurology 2004; 187(-2-):388-402. >>> Vascular endothelial growth factor 164, mouse; Flt-Fc; angiopoietin I, human; angiopoietin II, human; PBS; CSF/CNS (frontoparietal cortex); Rat; 2002; 1,2,3,4,5,7 days; Controls received mp w/ vehicle or hFc; dose-response (fig. 1); brain tissue distribution; peptides; cyanoacrylate adhesive (Loctite 495).

P6592 Dempsey,R.J., Sailor,K.A., Bowen,K.K., Tuereyen,K., Vemuganti,R. Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF. Journal of Neurochemistry 2003; 87(-3-):586-597. >>> Insulin-like growth factor I; glial-derived neurotrophic factor; CSF, artificial; CSF/CNS; Rat; 1 week; Controls received mp w/ vehicle; ALZET brain infusion kit used; peptides; ischemia (cerebral).

P6583 Suzuki,R., Tobe,K., Aoyama,M., Inoue,A., Sakamoto,K., Yamauchi,T., Kamon,J., Kubota,N., Terauchi,Y., Yoshimatsu,H., Matsuhisa,M., Nagasaka,S., Ogata,H., Tokuyama,K., Nagai,R., Kadowaki,T. Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2-/- mice. Journal of Biological Chemistry 2004; 279(-24-):25039-25049. >>> Leptin; CSF/CNS; Mice; 1003D; ; Controls received mp w/ saline; peptides.

P6559 Skuladottir,G.V., Olason,P.I., Jonsson,L., Skarphedinsson,J.O., Eriksdottir,V.H., Atlason,P.T., Franzson,L., Schioeth,H.B. Hyperphagia modifies FA profiles of plasma phospholipids, plasma FFA, and adipose tissue TAG. Lipids 2003; 38(-11-):1127-1132. >>> HS024; CSF, artificial; CSF/CNS; Rat; 2004; 8,28 days; Controls received mp w/ vehicle; stability verified by HPLC&MS weekly; ALZET brain infusion kit; peptides; Melanocortin receptor antagonist.

P6546 Asensio,C., Cettour-Rose,P., Theander-Carrillo,C., Rohner-Jeanrenaud,F., Muzzin,P. Changes in glycemia by leptin administration or high-fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis. Endocrinology 2004; 145(-5-):2206-2213. >>> Leptin, human; Saline, isotonic; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides.

P6541 Brooks,D.E., Kaellberg,M.E., Cannon,R.L., Komaromy,A.M., Ollivier,F.J., Malakhova,O.E., Dawson,W.W., Sherwood,M.B., Kuekuerichkina,E.E., Lambrou,G.X. Functional and structural analysis of the visual system in the rhesus monkey model of optic nerve head ischemia. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2004; 45(-6-):1830-1840. >>> Endothelin; Saline; acetic acid; CSF/CNS (optic nerve); Monkey; 18 months; Controls received mp w/ vehicle; long-term study; pumps replaced every 6 weeks; no stress (see pg. 1833); peptides; "The osmotic minipumps were well tolerated by the monkeys for the length (1.5 years) of the experiment." The long exposure time was used to "mimic more closely the prolonged human glaucomatous condition." p. 1838; pump model not listed; ischemia.

P6495 Raposinho,P.D., Pedrazzini,T., White,R.B., Palmiter,R.D., Aubert,M.L. Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 2004; 145(-1-):304-310. >>> Neuropeptide Y, porcine; Phosphate buffer; sodium chloride; ascorbic acid; BSA; CSF/CNS; Mice; 2001; 7 days; Controls received mp w/ vehicle; stress/adverse reaction: (see pg.305) initial weight loss from surgery/anesthesia; ALZET brain infusion kit 2 used; peptides; cyanoacrylate adhesive (Loctite 454).

P6489 Asilmaz,E., Cohen,P., Miyazaki,M., Dobrzyn,P., Ueki,K., Fayzikhodjaeva,G., Soukas,A.A., Kahn,C.R., Ntambi,J.M., Socci,N.D., Friedman,J.M. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. Journal of Clinical Investigation 2004; 113(-3-):414-424. >>> Leptin, recomb. mouse; SC; CSF/CNS (third ventricle); Mice; 12 days; Controls received mp w/ PBS; dose-response (fig.6); peptides.

P6453 Cui,Y.X., Huang,L., Elefteriou,F., Yang,G.Q., Shelton,J.M., Giles,J.E., Oz,O.K., Pourbahrami,T., Lu,C.Y.H., Richardson,J.A., Karsenty,G., Li,C. Essential role of STAT3 in body weight and glucose homeostasis. MOLECULAR AND CELLULAR BIOLOGY 2004; 24(-1-):258-269. >>> Leptin, recomb. human; Saline; CSF/CNS (third ventricle); Mice (knockout, transgenic); 2004; 28 days; ALZET brain infusion kit 2; peptides; obesity; diabetes.

P6442 Xu,B., Li,S., Brown,A., Gerlai,R., Fahnestock,M., Racine,R.J. EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats. MOLECULAR AND CELLULAR NEUROSCIENCE 2003; 24(-4-):984-999. >>> EphB2; EphA5; ephrin-A5; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; immunology; peptides; 7 day post surgical recovery; fusion proteins consisted of an IgG domain; immunoadhesins.

P6360 Windle,R.J., Kershaw,Y.M., Shanks,N., Wood,S.A., Lightman,S.L., Ingram,C.D. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. Journal of Neuroscience 2004; 24(-12-):2974-2982. >>> Oxytocin; vasopressin; Saline; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit; peptides; dental cement used.

P6342 Li,S., Saragovi,H.U., Racine,J.R., Fahnestock,M. A ligand of the p65/p95 receptor suppresses perforant path kindling, kindling-induced mossy fiber sprouting, and hilar area changes in adult rats. Neuroscience 2003; 119(-4-):1147-1156. >>> Reo 3Y; ReoL; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; no stress (see pg. 1149); peptides; post op. care (Penicllin, Apo-sulfatrim).

P6286 Pignataro,G., Tortiglione,A., Scorziello,A., Giaccio,L., Secondo,A., Severino,B., Santagada,V., Caliendo,G., Amoroso,S., Di Renzo,G., Annunziato,L. Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats. Neuropharmacology 2004; 46(-3-):439-448. >>> Glu-xip; Xip; CB-DMB; KB-R7943; FeCl3; Saline; DMSO; water; CSF/CNS; Rat; 1003D; 24 hours; Controls received mp w/ vehicle; dose-response (p. 444); peptides; ischemia (cerebral); cannula secured by cyanoacrylate adhesive&dental cement; KB-R7943 dissolved in 10% DMSO in water; all other agents dissolved in saline; agents are NCX (Na/Ca) inhibitors.

P6284 Elefteriou,F., Takeda,S., Ebihara,K., Magre,J., Patano,N., Kim,C.A., Ogawa,Y., Liu,X., Ware,S.M., Craigen,W.J., Robert,J.J., Vinson,C., Nakao,K., Capeau,J., Karsenty,G. Serum leptin level is a regulator of bone mass. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-9-):3258-3263. >>> Leptin; CSF/CNS; Mice (transgenic); ; ALZET brain infusion kit 2 used; peptides; recomb. human leptin used; no pump listed.

P6233 Shearman,L.P., Camacho,R.E., Stribling,D.S., Zhou,D., Bednarek,M.A., Hreniuk,D.L., Feighner,S.D., Tan,C.P., Howard,A.D., Van der Ploeg,L.H.T., MacIntyre,D.E., Hickey,G.J., Strack,A.M. Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. European Journal of Pharmacology 2003; 475(-1-3-):37-47. >>> Neuropeptide Y, rat; melanin-concentrating hormone-1, receptor agonist; melanin-concentrating hormone-1, receptor antagonist; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig. 5); peptides; post op. care (antisedan); pump model incorrectly given as 2001 (p. 39); based on flow rate (.5 ul/hr) and duration (14 days) is actually model 2002 (p. 39).

P6232 Hohmann,J.G., Krasnow,S.M., Teklemichael,D.N., Clifton,D.K., Wynick,D., Steiner,R.A. Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology 2003; 77(-6-):354-366. >>> Galanin; CSF, artificial; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume in pump; comparison of ICV injections vs. mp; ALZET brain infusion kit used; peptides; cyanoacrylate adhesive.

P6225 Brault,S., Martinez-Bermudez,A.K., Marrache,A.M., Gobeil,F.Jr, Hou,X., Beauchamp,M., Quiniou,C., Almazan,G., Lachance,C., Roberts,J.II, Varma,D.R., Chemtob,S. Selective neuromicrovascular endothelial cell death by 8-iso-prostaglandin F-2 alpha - Possible role in ischemic brain injury. Stroke 2003; 34(-3-):776-782. >>> Hydrogen Peroxide; Prostaglandin F2 alpha, 8-Iso-; CGS12970; U-46619; Urotensin II; CSF, artificial; CSF/CNS; Rat; 1 week; Controls received mp w/ vehicle; enzyme inhibitor (thromboxane A2 synthase); cardiovascular; peptides; U46619 is a thromboxane A2 synthase inhibitor; ischemia (cerebral).

P6219 Suo,Z.M., Wu,M., Citron,B.A., Gao,C.H., Festoff,B.W. Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation. Journal of Biological Chemistry 2003; 278(-33-):31177-31183. >>> Thrombin, alpha -; protease-activated receptor 1 agonist peptide; protease-activated receptor 4 agonist peptide; Saline; CSF/CNS (cortex); Rat; 1003D; 3 days; Peptides; recomb. human thrombin, alpha -, PAR1AP&PAR4AP used.

P6182 Li,L., Xu,Q., Wu,Y., Hu,W., Gu,P., Fu,Z. Combined therapy of methylprednisolone and brain-derived neurotrophic factor promotes axonal regeneration and functional recovery after spinal cord injury in rats. Chin Med.J.(Engl.) 2003; 116(-3-):414-418. >>> Brain-derived neurotrophic factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2ML2; 1, 3, 7 days; 6 weeks; Controls received mp w/ vehicle; peptides; 6ul/hr pump used.

P6156 Mondal,M.S., Yamaguchi,H., Date,Y., Shimbara,T., Toshinai,K., Shimomura,Y., Mori,M., Nakazato,M. A role for neuropeptide W in the regulation of feeding behavior. Endocrinology 2003; 144(-11-):4729-4733. >>> Neuropeptide W; Saline; CSF/CNS; Rat; 2001; 5 days; Controls received mp w/ vehicle; peptides; cannula placement verified by dye; obesity; NPW is a novel hypothalamic peptide.

P6115 Wang,H., White,R., Leenen,F.H.H. Stimulation of brain Na(+) channels by FMRFamide in Dahl SS and SR rats. American Journal of Physiology-Heart and Circulatory Physiology 2003; 285(-5-):H2013-H2018. >>> FMRFamide; CSF, artificial; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; blood pressure taken; stability verified by keeping solution at room temp. for 1 wk; cardiovascular; peptides; CSF production rate mentioned (p. H2014); FMRFamide dissolved in aCSF with a pH of 7.4 and stored at -20 celsius was found to be stable for 1 yr of storage.

P6110 Takahashi,K., Mizuarai,S., Araki,H., Mashiko,S., Ishihara,A., Kanatani,A., Itadani,H., Kotani,H. Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. Journal of Biological Chemistry 2003; 278(-47-):46654-46660. >>> Neuropeptide Y; monocyte chemoattractant protein-1; PBS; BSA; CSF/CNS; Mice; 2002; 2 weeks; Controls received mp w/ vehicle; mcp-1 plasma levels taken; ALZET brain infusion kit used; peptides; obesity; 7-14 day recovery period after surgery; pumps filled with PBS during recovery; monocyte chemoattractant protein-1 is also known as MCP-1.

P6101 Lupien,S.B., Bluhm,E.J., Ishii,D.N. Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. Journal of Neuroscience Research 2003; 74(-4-):512-523. >>> Insulin-like growth factor; antiserum, human IGF II; serum, preimmune; Acetic acid; CSF, artificial; SC; CSF/CNS; Rat; 7.5 weeks; Pumps replaced every 19 days; ALZET brain infusion kit used; peptides; diabetes; IGF delivered SC and separate study for ICV infusion of anti-IGF-II antiserum or preimmune serum; (PIS) dissolved in aCSF; cannulae placement verified post experiment by bromophenol blue.

P6086 Pal,R., Sahu,A. Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 2003; 144(-9-):3789-3798. >>> Leptin; CSF; artificial; CSF/CNS; Rat; 2002; 16 days; Controls received mp w/ vehicle; leptin plasma levels taken; peptides; plastics one cannula used; first pump filled with aCSF served as a recovery.

P6053 Chen,Z.L., Indyk,J.A., Strickland,S. The hippocampal laminin matrix is dynamic and critical for neuronal su rvival. MOLECULAR BIOLOGY OF THE CELL 2003; 14(-7-):2665-2676. >>> Laminin-1; PBS; CSF/CNS (hippocampus); Mice (knockout); 1007D; 5 days; Peptides.

P5996 Emsley,J.G., Hagg,T. Alpha6beta1 integrin directs migration of neuronal precursors in adult mouse forebrain. Experimental Neurology 2003; 183(-2-):273-285. >>> Laminin polypeptide; Acetic acid; rat serum albumin; gentamicin; CSF/CNS (neostriatum); Mice; 1002; 14 days; Controls received mp w/ vehicle; peptides; cannula affixed to the skull with cyanoacrylate adhesive (loctite 454); 3.0 mm long cannula; laminin is an A6B1 integrin ligand; schematic diagram of cannula placement (fig. 3; p. 278).

P5993 Lukoyanov,N.V., Pereira,P.A., Paula-Barbosa,M.M., Cadete-Leite,A. Nerve growth factor improves spatial learning and restores hippocampal cholinergic fibers in rats withdrawn from chronic treatment with ethanol. Experimental Brain Research 2003; 148(-1-):88-94. >>> Nerve growth factor; CSF, artificial; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; peptides; behavioral study.

P5968 Melchior,B., Nerriere-Daguin,V., Laplaud,D.A., Remy,S., Wiertlewski,S., Neveu,I., Naveilhan,P., Meakin,S.O., Brachet,P. Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. Experimental Neurology 2003; 183(-2-):367-378. >>> Nerve growth factor; Saline; Sodium bicarbonate; potassium chloride; KH2; P04; calcium chloride; magnesium chloride; sodium sulfate; glucose; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; neurodegenerative (Alzheimer's disease, Parkinson's disease); NGF was recomb. human.

P5965 Cadete-Leite,A., Pereira,P.A., Madeira,M.D., Paula-Barbosa,M.M. Nerve growth factor prevents cell death and induces hypertrophy of basil forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intake. Neuroscience 2003; 119(-4-):1055-1069. >>> Nerve growth factor; dye, methylene blue; CSF; BSA; CSF/CNS; Rat; 2004; 28 days; good methods p. 1057; ALZET brain infusion kit 1 used; peptides; post op. care (sc injection of saline and cortrimoxazol); lynch coil used; air bubble used to separate vehicle and agent/vehicle; pump contained dye.

P5948 Prass,K., Scharff,A., Ruscher,K., Loewl,D., Muselmann,C., Victorov,I., Kapinya,K., Dirnagl,U., Meisel,A. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003; 34(-8-):1981-1986. >>> Erythropoietin, soluble receptor; PBS; BSA; CSF/CNS; Mice; 1003D; 64 hours; Controls received mp w/ vehicle; peptides; ischemia (cerebral); human EPO used; 0.1%BSA used in vehicle.

P5915 Calza,L., Giuliani,A., Fernandez,M., Pirondi,S., D'Intino,G., Aloe,L., Giardino,L. Neural stem cells and cholinergic neurons: Regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O F AMERICA 2003; 100(-12-):7325-7330. >>> Epidermal growth factor; fibroblast growth factor, basic; Nerve growth factor; PBS, sterile; CSF/CNS; Rat; 2002; 28; Controls received mp w/ aCSF; pumps replaced every 14 days for 28 days; ALZET brain infusion kit used; peptides; behavioral study; NGF dissolved in PBS; EGF&FGF were infused for 14 days, followed by a 14 day infusion of NGF; stem cell related study.

P5904 Tropea,D., Caleo,M., Maffei,L. Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats. Journal of Neuroscience 2003; 23(-18-):7034-7044. >>> Brain-derived neurotrophic factor; CSF/CNS (superior collicus); Rat; 1007D; 1 week; Controls received mp w/ cyctochrome c; peptides.

P5865 Vonhof,S., Gudka,B.D., Siren,A.L. Tolerance and dependence following chronic intracerebroventricular infusions of Tyr-D-Arg(2)-Phe-Sar(4) (TAPS). European Journal of Pharmacology 2003; 459(-1-):41-48. >>> Morphine sulfate; Enkephalin analog DAMGO; Dermorphin-derived tetrapeptide (TAPS); CSF, artifical; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle; comparison of bolus injections vs. chronic mp; pumps replaced on day 4 to achieve 6 days due to dead space in catheter; ALZET brain infusion kit used; tolerance; dependence; peptides; second hole with guide cannula&stylet used for bolus injections; (ALZET) cannula placement confimed by fast green dye&the guide cannula confirmed by methylene blue; TAPS is a potent mu-opioid receptor agonist.

P5852 Raposinho,P.D., White,R.B., Aubert,M.L. The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Journal of Neuroendocrinology 2003; 15(-2-):173-181. >>> Melanotan-II; Neuropeptide Y; PBS; Ascorbic Acid; BSA; CSF/CNS; Rat; 7 days; Peptides; Melanotan II or MTII (a melanocortin receptor agonist)&neuropeptide were dissolved in PBS, 0.01% ascorbic acid, 0.1% bovine serum albumin adjusted to ph 7.4; pump model not listed.

P5842 Porter,J.P., Anderson,J.M., Robison,R.J., Phillips,A.C. Effect of central angiotensin II on body weight gain in young rats. Brain Research 2003; 959(-1-):20-28. >>> Angiotensin II; Saline, sterile; SC; CSF/CNS; Rat; 2002; 1 week; Controls received mp w/ vehicle; dose-response (p.24); comparison of SC infusion vs I.C.U. infusion; ALZET brain infusion kit used; peptides; "fast green dye was infused to verify potency of infusion system of the end of the experiment" p.21.

P5830 Dobbins,R.L., Szczepaniak,L.S., Zhang,W.G., McGarry,J.D. Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2003; 284(-4-):E778-E787. >>> Leptin; PBS; BSA; CSF/CNS (third ventricle); Rat; 2002; 10 days; Controls received mp w/ vehicle; peptides; leptin dissolved in PBS&0.2% bovine srum albumin; plastics one cannula used.

P5828 Tschop,M., Smiley,D.L., Heiman,M.L. Ghrelin induces adiposity in rodents. Nature 2003; 407(-6806-):908-913. >>> Ghrelin; Water; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig 4a; pg 911); peptides; 1 ul/hr pump model for 7 days; obesity research.

P5827 Kas,M.J.H., van Dijk,G., Scheurink,A.J.W., Adan,R.A.H. Agouti-related protein prevents self-starvation. Molecular Psychiatry 2003; 8(-2-):235-240. >>> Agouti-related protein; Saline; CSF/CNS; Rat; 1007D; 4-5 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; peptides; catheter tubing filled w/ saline to allow 2-3 day delayed infusion; Agouti-related protein is a suppressor of melanocortin receptor activity.

P5823 Liberatore,G.T., Samson,A., Bladin,C., Schleuning,W.D., Medcalf,R.L. Vampire bat salivary plasminogen activator (desmoteplase) - A unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke 2003; 34(-2-):537-543. >>> Tissue-type plasminogen activator; Desmoteplase; PBS; CSF/CNS; Mice (knockout); 1007D; 7 days; Controls received mp w/ vehicle; peptides; Desmoteplase is a vampire bat salivary plasminogen activator (a fibrinolytic enzyme); neurodegeneration; tissue plasminogen activator is also known as alteplase.

P5712 Fukaya,K., Hasegawa,M., Mashitani,T., Kadoya,T., Horie,H., Hayashi,Y., Fujisawa,H., Tachibana,O., Kida,S., Yamashita,J. Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury. Journal of Neuropathology and Experimental Neurology 2003; 62(-2-):162-172. >>> Amyloid protein, beta (1-40); Amyloid protein, beta (40-1); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle and reverse peptide 40-1; peptides; 35% acetonitrile and 0.1% trifluoroacetic acid vehicle; neurodegenerative (Alzheimer's disease).

P5632 Wahle,P., Di Cristo,G., Schwerdtfeger,G., Engelhardt,M., Berardi,N., Maffei,L. Differential effects of cortical neurotrophic factors on development of lateral geniculate nucleus and superior colliculus neurons: anterograde and retrograde actions. Development 2003; 130(-3-):611-622. >>> Nerve growth factor; NT-4/5; brainderived neurotrophic factor; leukemia inhibitory factor; CSF/CNS (visual cortex); Rat; 1007D; 7 days; Controls received mp w/ cytochrome C; peptides..

P5606 Harrigan,M.R., Ennis,S.R., Sullivan,S.E., Keep,R.F. Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume. Acta Neurochirurgica 2003; 145(-1-):49-53. >>> Vascular endothelial growth factor 165; PBS; BSA; CSF/CNS; Rat; 2001; 7 days; Controls received mp/ w vehicle; cardiovascular; peptides; ALZET brain infusion kit used; VEGF was recomb. human; ischemia (cerebral).

P5605 Gomori,A., Ishihara,A., Ito,M., Mashiko,S., Matsushita,H., Yumoto,M., Ito,M., Tanaka,T., Tokita,S., Moriya,M., Iwaasa,H., Kanatani,A. Chronic intracerebroventricular infusion of MCH causes obesity in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2003; 284(-3-):E583-E588. >>> Melanin-concentrating hormone; Propylene glycol; CSF/CNS; Mice; 2001; 14 days; Controls received mp/ w vehicle; peptides; ALZET brain infusion kit used; 1st pump with vehicle only to allow for recovery (7-14 days), then the pump was replaced for MCH infusion; obesity.

P5597 Fournier,A.E., Takizawa,B.T., Strittmatter,S.M. Rho kinase inhibition enhances axonal regeneration in the injured CNS. Journal of Neuroscience 2003; 23(-4-):1416-1423. >>> C3 Transferase; Glutathione S-transferase; Y-27632; PBS; CSF/CNS (intrathecal); Rat; 2002; 2-3 weeks; Enzyme inhibitor (protein kinase); peptides; spinal cord injury; Y-27632 is a Rho-associated kinase (ROCK) inhibitor.