References on the Administration of Cortisol Using ALZET® Osmotic Pumps

13371 Feng, X.D., Reini, S.A., Richards, E., Wood, C.E., Keller-Wood, M. Cortisol stimulates proliferation and apoptosis in the late gestation fetal heart: differential effects of mineralocorticoid and glucocorticoid receptors. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2013; 305(-4-):R343-R350. >>> Cortisol; potassium canrenoate; mifepristone; Saline; SC; Sheep (ewe); 2ML2; Controls received mp w/ vehicle; animal info (female, singleton pregnancies); teratology; cardiovascular; impact of maternal stress during late gestation.

13264 Kleppe, L., Karlsen, O., Edvardsen, R.B., Norberg, B., Andersson, E., Taranger, G.L., Wargelius, A. Cortisol treatment of prespawning female cod affects cytogenesis related factors in eggs and embryos. General and Comparative Endocrinology 2013; 189(-;-):84-95. >>> Cortisol; propranediol; Hydrocortisone; IP; Fish; Controls received mp w/ 80% 1.2-propanediol; animal info (cod, 1.8kg, female); 2ML pump used.

12869 Dorniak, P., Welsh, TH Jr, Bazer, F.W., Spencer, T.E. Cortisol and Interferon Tau Regulation of Endometrial Function and Conceptus Development in Female Sheep. Endocrinology 2013; 154(-2-):931-941. >>> Cortisol; PF915275; meloxicam; interferon, tau, recomb. ovine; Ethanol; Intrauterine (uterine horn); Sheep (ewe); 2ML1; Control animals received mp w/ vehicle; animal info (mature, rambouillet, female, ewe); 2% ethanol used; vinyl catheter used (0007760);"Our previous studies found that infusion of that amount of IFNT in the uterine lumen each day mimics effects of the conceptus on endometrial expression of hormone receptors and IFNT-stimulated genes during early pregnancy in ewes"pg 932.

7336 Martinez, A.S., Cutler, C.P., Wilson, G.D., Phillips, C., Hazon, N., Cramb, G. Regulation of expression of two aquaporin homologs in the intestine of the European eel: effects of seawater acclimation and cortisol treatment. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2005; 288(-6-):R1733-R1743. >>> Cortisol; Cyclodextrin, beta; IP; Fish (eel); 1003D; Controls received mp w/ vehicle; cortisol plasma levels; yellow/silver eels with an ambient temp. of 5-14 degrees celsius, 30 degrees celsius Cyclodextrin used; pumps implanted IP; per contact with author; 30% cyclodextrin used.

7339 Martinez, A.S., Cutler, C.P., Wilson, G.D., Phillips, C., Hazon, N., Cramb, G. Cloning and expression of three aquaporin homologues from the European eel (Anguilla anguilla): effects of seawater acclimation and cortisol treatment on renal expression. Biology of the Cell 2005; 97(-8-):615-627. >>> Cortisol; Cyclodextrin, beta; IP; Fish (eel); 1003D; Controls received mp w/ vehicle; functionality of mp verified by cortisol plasma levels; pumps implanted IP per contact with author; 30% cyclodextrin used.

6269 Metz, J.R., van den Burg, E.H., Bonga, S.E.W., Flik, G. Regulation of branchial Na+/K+-ATPase in common carp Cyptinus carpio L . acclimated to different temperatures. Journal of Experimental Biology 2003; 206(-13-):2273-2280. >>> Cortisol; Cyclodextrin, beta; IP; Fish (carp); 1007D; Controls received mp w/ vehicle; functionality of mp verified by cortisol plasma levels taken;"this approach was used instead of cortisol injection, which evokes stress responses due to repetitive handling..."(p. 2275); 30% cyclodextrin used.

5462 Pacak, K., Tjurmina, O., Palkovits, M., Goldstein, D.S., Koch, C.A., Hoff, T., Chrousos, G.P. Chronic hypercortisolemia inhibits dopamine synthesis and turnover in the nucleus accumbens: An in vivo microdialysis study. Neuroendocrinology 2002; 76(-3-):148-157. >>> Cortisol; SC; Rat; 2001; Controls received mp w/ saline.

3455 Wolfovitz, E., Pacak, K., Abassi, Z., Kopin, I.J., Goldstein, D.S. Effects of hypercortisolemia or hyperinsulinemia on neurochemical indices of catecholamine release and synthesis in conscious rats. J. Auton. Nerv. Syst 1995; 54(--):104-112. >>> Cortisol; Saline; SC; rat; controls received mp w/saline.

3434 Pacak, K., Palkovits, M., Kvetnansky, R., Matern, P., Hart, C., Kopin, I.J., Goldstein, D.S. Cathecholaminergic inhibition by hypercortisolemia in the paraventricular nucleus of conscious rats. Endocrinology 1995; 136(-11-):4814-4819. >>> Cortisol; SC; rat; 2001; controls received mp w/saline.

3347 Lobo, M.J., Remesar, X., Alemany, M. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Biochem. Molec. Biol. Intl 1993; 29(-2-):349-358. >>> Progesterone; Cortisol; Cortisone; Corticosterone; Dehydroepiandrosterone; Androstenedione, 4-; Androstendiol, 5-; Testosterone; Nortestosterone, 19-; Estradiol, B-; Estrone; Estriol; Deoxycorticosterone; PEG 400; IV (lower cava); rat; 2002; controls received mp with PEG; no stress (see pg. 351); pumps placed into peritoneal cavity and sutured to musculature; surgical wound sprinkled with sulphathiazol.

3325 Kvetnansky, R., Fukuhara, K., Pacak, K., Cizza, G., Goldstein, D.S., Kopin, I.J. Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats. Endocrinology 1993; 133(-3-):1411-1419. >>> Cortisol; Saline; SC; rat; 2001; no comment posted.

3105 Shrimpton, J.M., Randall, D.J. Downregulation of corticosteroid receptors in gills of coho salmon due to stress and cortisol treatment. Am. J. Physiol 1994; 267(-36-):R432-R438. >>> Cortisol, 21-hemisuccinate; Saline; Cyclodextrin; IP; fish; controls received mp w/ vehicle or no surgery; functionality of mp verified by plasma levels; comparison of ip injections and daily handling vs. mp; no stress (see pg. R433); stability verified for 18 days at 7.5 degrees C; only chronic infusion resulted in reduction of corticosteroid receptor number and affinity; cyclodextrin was Molecusol HBP.

3060 Sangild, P.T., Hilsted, L., Nexo, E., Fowden, A.L., Silver, M. Secretion of acid, gastrin, and cobalamin-binding proteins by the fetal pig stomach: developmental regulation by cortisol. Exp. Physiology 1994; 79(--):135-146. >>> Cortisol; SC; pig (fetus); 2001; controls received mp with saline or no operation; mp implanted just behind ribs; ampicillin given via amniotic fluid.

3059 Sangild, P.T., Silver, M., Fowden, A.L., Turvey, A., Foltmann, B. Adrenocortical stimulation of stomach development in the prenatal pig. Biol. Neonate 1994; 65(--):378-389. >>> Cortisol; ACTH(1-24); Saline; SC; pig (fetus); 2001; controls received mp with saline; peptides.

3058 Sangild, P.T., Westrom, B.R., Fowden, A.L., Silver, M. Developmental regulation of the porcine exocrine pancreas by glucocorticoids. J. Pediatr. Gastroenterology and Nutrition 1994; 19(--):204-212. >>> Cortisol; ACTH; Saline; SC; pig (fetus); 2001; controls received mp with saline; peptides; no stress: mp was generally well tolerated; the cortisol used was hydrocortisone hemisuccinate.

3005 Pacak, K., Kvetnansky, R., Palkovits, M., Fukuhara, K., Yadid, G., Kopin, I.J., Goldstein, D.S. Adrenalectomy augments in vivo release of norepinephrine in the paraventricular nucleus during immobilization stress. Endocrinology 1993; 133(--):1404-1410. >>> Cortisol; Saline; SC; rat; 2002; controls received mp with vehicle or sham operation; replacement therapy (adrenalectomy).

2952 Sangild, P.T., Sjostrom, H., Noren, O., Fowden, A.L., Silver, M. The prenatal development and glucocorticoid control of brush-border hydrolases in the pig small intestine. Pediatr. Res 1995; 37(-2-):207-212. >>> Cortisol; Saline; SC; pig (fetus); 2001; controls received mp with saline; after surgery fetuses received 50 mg of ampicillin into the amniotic cavity; sows maintained on antibiotics 3-4 days after surgery.

2924 Popnikolov, N.K., Yang, J., Guzman, R.C., Swanson, S.M., Thordarson, G., Collins, G., Talamantes, F., Nandi, S. In vivo growth stimulation of collagen gel embedded normal human and mouse primary mammary epithelial cells. J. Cell. Physiology 1995; 163(--):51-60. >>> Epidermal growth factor; Cortisol; Toxin, cholera; Uridine, bromodeoxy-;; Medium 199;; SC; gel;; Mice (nude);; 1003D;; peptides;"tissue perfusion"-- gel containing human mammary epithelial cells was infused; estradiol, progesterone, and cholesterol combinations administered via silastic capsules EGF cholera toxin and hydrocortisone stimulated DNA synthesis substantially with the greatest response seen in the gel proximal to the pump: local delivery appears to be superior to injection;.

2768 Chatterton, R.T., Kazer, R.R., Rebar, R.W. Depletion of luteal phase serum progesterone during constant infusion of cortisol phosphate in the cynomolgus monkey. Fertil. Steril 1991; 56(-3-):547-554. >>> Cortisol 21-phosphate; Saline; SC; monkey; 2001; 2ML2; controls received mp w/ saline; functionality of mp verified by plasma level assay; pumps replaced every 7 or 14 days; long-term study.

2682 Andersen, D.E., Reid, S.D., Moon, T.W., Perry, S.F. Metabolic effects associated with chronically elevated cortisol in rainbow trout (Oncorhynchus mykiss). Can. J. Fish. Aquat. Sci 1991; 48(-9-):1811-1817. >>> Cortisol; Cyclodextrin, B-; IA (dorsal aorta); fish (rainbow trout); 2001; controls received mp w/ vehicle or sham operation; functionality of mp verified by RIA of plasma levels; stress from surgery caused hyperglycemia (p.816) for 22 hours;"Mini-osmotic pumps. . .were an effective method for chronically elevating cortisol titers in trout."; Molecusol HBP is a beta-cyclodextrin.

2466 Pacak, K., Armando, I., Komoly, S., Fukuhara, K., Weise, V.K., Holmes, C., Kopin, I.J., Goldstein, D.S. Hypercortisolemia inhibits yohimbine-induced release of norepinephrine in the posterolateral hypothalamus of conscious rats. Endocrinology 1992; 131(-3-):1369-1376. >>> Cortisol; Saline; SC; rat; 2001; controls received mp w/ vehicle; microdialysis.

2021 Teicher, B.A., Sotomayor, E.A., Huang, Z.D. Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease. Cancer Res 1992; 52(--):6702-6704. >>> Cyclodextrin-beta tetradecasulfate; Cortisol, tetrahydro-; SC; mice; 2002; cancer.

1545 Szemeredi, K., Zukowska-Groject, Z., Bagdy, G., Fekete, M.I., Kopin, J. Opposite effects of chronic cortisol treatment on pre- and postsynaptic actions of clonidine in pithed rats. J. Auton. Pharmac 1989; 9(--):35-43. >>> Cortisol; Saline; SC; rat; 2001; dose-response; functionality of mp verified by plasma levels.

1303 Szemeredi, K., Bagdy, G., Stull, R., Calogero, A.E., Kopin, I.J., Goldstein, D.S. Sympathoadrenomedullary inhibition by chronic glucocorticoid treatment in conscious rats. Endocrinology 1988; 123(-5-):2585-2590. >>> Cortisol; Saline; SC; rat; 2001; dose-response; functionality of mp verified by plasma levels.

1269 Elam, M.B., Simkevich, C.P., Solomon, S.S., Wilcox, H.G., Heimberg, M. Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo. Endocrinology 1988; 122(-4-):1397-1402. >>> Cortisol; Growth hormone, human; Triiodothyronine; Sodium hydroxide; Saline; SC; rat; pump model not stated; male rats infused for 7 days, females for 14; agents infused separately; replacement therapy (hypophysectomy); peptides.

612 Phillips, R., Crock, C., Funder, J. Effect of mineralocorticoids and glucocorticoids on compensatory adrenal growth in rats. Am. J. Physiol 1985; 248(-4-):E450-E456. >>> Aldosterone; Fluorocortisol acetate, 9a-; Corticosterone; Deoxycorticosterone; Dexamethasone; Ethanol; Propylene glycol; Water; SC; rat; replacement therapy (unilateral adrenalectomy); each mp used twice, 3 days in one animal, then 3 days in another; cannot tell if stability/concentration of ald. determined by RIA before or after exp.


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What researchers are saying...

"Utilizing continuous minipump administration enhances the knockdown to 63% of control." (p. 619) This compared with 40% by twice daily administration. "The results of the present study confirm the utility of osmotic minipump administration of antisense oligonucleotides." (p. 621) Falk et al., Pharmacol Biochem Behav 2002;72:617-622.