References on the Administration of Cytokines Using ALZET® Osmotic Pumps

1. Colony-Stimulating Factor, G

16294 Caviness, K., Bughio, F., Crawford, L. B., Streblow, D. N., Nelson, J. A., Caposio, P., Goodrum, F. Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency. MBio 2016; 7(-2-):e01986. >>> Colony-stimulating factor, G; AMD3100; IP; Mice (NOD/SCID); 1007D; animal info (NOD-scid humanized (huNSG) mice); gene therapy; immunology; Engraftment of human CD45+ cells; viral persistence; Dose (300mg/ml Colony-stim; 125 ug AMD3100);.

12101 Dittgen, T., Pitzer, C., Plaas, C., Kirsch, F., Vogt, G., Laage, R., Schneider, A. Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury. PLoS One 2012; 7(-1-):U282-U286. >>> Colony-stimulating factor, G; Tween 80; sorbitol; acetic acid; sodium acetate; SC; Rat; Controls received mp w/ vehicle; animal info (Wistar, female, 300 g); half-life (~4 hours) pg e29881;"This treatment scheme was chosen because of the limited plasma half-life of G-CSF."pg e29881.

11554 Pitzer, C., Klussmann, S., Krueger, C., Letellier, E., Plaas, C., Dittgen, T., Kirsch, F., Stieltjes, B., Weber, D., Laage, R., Martin-Villalba, A., Schneider, A. The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury. Journal of Neurochemistry 2010; 113(-4-):930-942. >>> Colony-stimulating factor, G; Sorbitol; Tween 80; sodium acetate buffer; SC; Mice; Controls received mp w/ vehicle; animal info (female, 2 mo old, C57BL/6); half-life ~ 4 hours (p. 934); no stress (see pg. 931);"We did not observe signs of local irritation or signs of infection over the time period of 5 weeks";"Continuous delivery via osmotic pump was chosen to maintain constant plasma levels of the protein despite its rather short plasma half-life"pg 934; spinal cord injury.

10848 Smith, M.S., Goldman, D.C., Bailey, A.S., Pfaffle, D.L., Kreklywich, C.N., Spencer, D.B., Othieno, F.A., Streblow, D.N., Garcia, J.V., Fleming, W.H., Nelson, J.A. Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model. Cell Host&Microbe 2010; 8(-3-):284-291. >>> Colony-stimulating factor, G; AMD 3100; SC; Mice (NOG); 1007D; Controls received mp w/ PBS; animal info (7-10 wks old, NOD-scid, IL2Rgc null); immunology.

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2. Colony-Stimulating Factor, GM

13934 Zhu, F., Liu, Y., Zhao, J., Zheng, Y., Zhao, J. MINOCYCLINE ALLEVIATES BEHAVIORAL DEFICITS AND INHIBITS MICROGLIAL ACTIVATION INDUCED BY INTRAHIPPOCAMPAL ADMINISTRATION OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN ADULT RATS. Neuroscience 2014; 266(--):275-281. >>> Colony stimulating factor, GM, recombinant rat; Saline; CSF/CNS (hippocampus); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 280-320g); ALZET brain infusion kit 3 used; Multiple pumps per animal (2); behavioral testing (locomotor activity; social interaction test; PPI); used dental acrylic resin; schizophrenia;.

11004 Driessens, G., Nuttin, L., Gras, A., Maetens, J., Mievis, S., Schoore, M., Velu, T., Tenenbaum, L., Preat, V., Bruyns, C. Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery. CANCER IMMUNOLOGY IMMUNOTHERAPY 2011; 60(-2-):273-281. >>> Colony-stimulating factor, GM; SC; Rat; 2004; Animal info (male, inbred, Fischer 344, 10-12 wks old); comparison of"all in-vivo therapy"vs mp; cancer.

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3. Colony-Stimulating Factor, M

13923 Sawada, H., Saito, T., Nickel, N.P., Alastalo, T.P., Glotzbach, J.P., Chan, R., Haghighat, L., Fuchs, G., Januszyk, M., Cao, A.Q., Lai, Y.J., Perez, V.D., Kim, Y.M., Wang, L.L., Chen, P.I., Spiekerkoetter, E., Mitani, Y., Gurtner, G.C., Sarnow, P., Rabinovitch, M. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. Journal of Experimental Medicine 2013; 211(-2-):263-280. >>> Antibody, rat anti-mouse IgG macrophage colony-stimulating factor; SC; Mice; 1002; Controls received mp w/ control antibody IgG2a; animal info (C57BL6, 8 weeks old); cardiovascular; immunology;.

10872 Lloyd, S.A., Yuan, Y.Y., Simske, S.J., Riffle, S.E., Ferguson, V.L., Bateman, T.A. Administration of high-dose macrophage colony-stimulating factor increases bone turnover and trabecular volume fraction. JOURNAL OF BONE AND MINERAL METABOLISM 2009; 27(-5-):546-554. >>> Colony-stimulating factor, M; SC; Mice; Animal info (male, C57BL/6 J, 7 wks old); comparison of SC injections vs mp; lack of cortical response in both daily injection and pump studies, pg 550.

3211 Vallera, D.A., Taylor, P.A., Aukerman, S.L., Blazar, B.R. Antitumor protection from the murine T-cell leukemia/lymphoma EL4 by the continuous subcutaneous coadministration of recombinant macrophage-colony stimulating factor and interleukin-2. Cancer Res 1993; 53(--):4273-4280. >>> Colony-stimulating factor, M; Interleukin-2; Colony-stimulating factor, G; SC; mice; controls received mp with PBS; cancer; immunology; peptides; M-CSF + IL-2 given concomitantly provided best antitumor protection; recomb. IL-2 used; human G-CSF used.

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4. Colony-stimulating Factor, G

Q1830 Dittgen,T., Pitzer,C., Plaas,C., Kirsch,F., Vogt,G., Laage,R., Schneider,A. Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury. PLoS One 2012; 7(-1-):U282-U286. >>> Colony-stimulating factor, G; Tween 80; sorbitol; acetic acid; sodium acetate; SC; Rat; 14 days; Controls received mp w/ vehicle; animal info (Wistar, female, 300 g); half-life (~4 hours) pg e29881; "This treatment scheme was chosen because of the limited plasma half-life of G-CSF." pg e29881.

Q1283 Pitzer,C., Klussmann,S., Krueger,C., Letellier,E., Plaas,C., Dittgen,T., Kirsch,F., Stieltjes,B., Weber,D., Laage,R., Martin-Villalba,A., Schneider,A. The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury. Journal of Neurochemistry 2010; 113(-4-):930-942. >>> Colony-stimulating factor, G; Sorbitol; Tween 80; sodium acetate buffer; SC; Mice; 2 weeks; Controls received mp w/ vehicle; animal info (female, 2 mo old, C57BL/6); half-life ~ 4 hours (p. 934); no stress (see pg. 931); "We did not observe signs of local irritation or signs of infection over the time period of 5 weeks"; "Continuous delivery via osmotic pump was chosen to maintain constant plasma levels of the protein despite its rather short plasma half-life" pg 934; spinal cord injury.

Q0599 Smith,M.S., Goldman,D.C., Bailey,A.S., Pfaffle,D.L., Kreklywich,C.N., Spencer,D.B., Othieno,F.A., Streblow,D.N., Garcia,J.V., Fleming,W.H., Nelson,J.A. Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model. Cell Host&Microbe 2010; 8(-3-):284-291. >>> Colony-stimulating factor, G; AMD 3100; SC; Mice (NOG); 1007D; 7 days; Controls received mp w/ PBS; animal info (7-10 wks old, NOD-scid, IL2Rgc null); immunology.

Q0560 Bonig,H., Chudziak,D., Priestley,G., Papayannopoulou,T. Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100. Experimental Hematology 2009; 37(-3-):402-415. >>> AMD 3100; colony-stimulating factor, G, recomb. human; PBS; BSA; SC; Mice; 2001; 9 days; Controls received sham mp; animal info (B6x129, C57Bl/6 wt); comparison of SC injections vs mp; "as a single-agent HSPC-mobilizing strategy, single-bolus injection of AMD3100 is relatively inefficient..." pg 410; "... the data presented here for continuous infusion of AMD3100 demonstrate superb HSPC mobilizing potency." pg 411.

Q0293 Jobst,B.J., Riegger,G.A.J., Griese,D.P. Endothelial Cell Seeding Fails to Prevent Intimal Hyperplasia Following Arterial Injury in the Rat Carotid Model. Cardiovascular Drugs and Therapy 2009; 23(-5-):343-353. >>> Colony-stimulating factor, G, human, recomb.; erythropoietin, human, recomb.; IP; Rat; 2ML1; 48 hours; Controls received mp w/ saline; animal info (male, CD, 250 g, splenectomy).

P9435 Pitzer,C., Krueger,C., Plaas,C., Kirsch,F., Dittgen,T., Mueller,R., Laage,R., Kastner,S., Suess,S., Spoelgen,R., Henriques,A., Ehrenreich,H., Schaebitz,W.R., Bach,A., Schneider,A. Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain 2008; 131(--):3335-3347. >>> Colony-stimulating factor, G; Sorbitol; sodium acetate buffer; tween 80; SC; Mice (transgenic); 2004; 4, 8 weeks; 4 days; Controls received mp w/ vehicle; functionality of mp verified by G-CSF serum concentration; replacement therapy (sciatic nerve axotomy); long-term study; pumps replaced after 4 weeks; half-life (p. 5) 4 hours in humans and rodents; brain tissue distribution; peptide; animal info (female, C57BL/6, wt, SOD1(G93A)Tg, 11 wks old); neurodegenerative (ALS); behavioral testing (rotarod test, motor performance); 0.004% Tween 80 used.

P9049 Hack,M., Mascha,F.G., Jobst,B.J., Riegger,G.A.J., Griese,D.P. A systemic combination therapy with granulocyte-colony stimulating factor plus erythropoietin aggravates the healing process of balloon-injured rat carotid arteries. Cardiovascular Drugs and Therapy 2008; 22(-5-):351-362. >>> Colony-stimulating factor, G-, recomb. human; erythropoietin; IP; Rat; 2ML1; 7 days; Controls received mp w/ saline; peptides; animal info (male, Sprague Dawley, 300-350 g., splenectomy); "We used implantable osmotic minipumps to guarantee continuous systemic delivery of the tested cytokines over the first even days upon intraperitoneal deposition." pg. 353.

P8372 Bonig,H., Priestley,G.V., Oehler,V., Papayannopoulou,T. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Experimental Hematology 2007; 35(-2-):326-334. >>> Colony-stimulating factor, G, recomb. human; SC; Mice (NOD/SCID); 2001; 5 days; Peptides; hematology.

P8288 Capoccia,B.J., Shepherd,R.M., Link,D.C. G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood 2006; 108(-7-):2438-2445. >>> Colony-stimulating factor, G, recomb. human; PBS; SC; Mice; mice (transgenic); 5, 7 days; Controls received mp w/ vehicle; cardiovascular; peptides; ischemia (hind limb); animal info (C57BL/6, 8-10 weeks old); ischemia; acute vascular injury.

P7762 Jung,K.H., Chu,K., Lee,S.T., Kim,S.J., Sinn,D.I., Kim,S.U., Kim,M., Roh,J.K. Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Research 2006; 1073(--):190-201. >>> Colony-stimulating factor, G, recomb.; Saline; CSF/CNS; Rat; 2002; 7 days; Controls received mp w/ vehicle; no stress (see pg. 199); peptides; animal info (male, Sprague-Dawley, 220-240g).

P7304 Ulyanova,T., Scott,L.M., Priestley,G.V., Jiang,Y., Nakamoto,B., Koni,P.A., Papayannopoulou,T. VCAM-1 expression in adult hematopoietic and nonhernatopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 2005; 106(-1-):86-94. >>> Colony-stimulating Factor, G; Flt-3 ligand; Mice (transgenic); mice; 2001; 5, 7 days; comparison of IP injections vs. mp; VCAM-1 ablated mice.

P6857 Doyonnas,R., LaBarge,M.A., Sacco,A., Charlton,C., Blau,H.M. Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-37-):13507-13512. >>> Colony-stimulating factor, G, recomb. mouse; SC; Mice (transgenic); 5 days.

P4380 Molineux,G., McCrea,C., Yan,X.Q., Kerzic,P., McNiece,I. Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential.. Blood 1997/6/1; 89(-11-):3998-4004. >>> Colony-stimulating factor, G; Flt-3 ligand;; PBS; BSA;; SC;; mice;; 1007D;; 7 days;; controls received mp with vehicle; comparison of injections vs. mp; peptides; recomb. human flt-3 ligand and G-CSF used;.

P4291 Roeder,I., de Haan,G., Engel,C., Nijhof,W., Dontje,B., Loeffler,M. Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 1998/5/1; 91(-9-):3222-3229. >>> Interleukin-11; Stem cell factor; Colony-stimulating factor, G; Erythropoietin;; SC;; mice;; 2002; 1007D;; 7 days;; controls received mp w/ saline; functionality of mp verified by pilot studies; no stress (see pg. 3223); peptides; recomb. human interleukin-11, EPO,&G-CSF used; recomb. rat stem cell factor used (pegylated);agents were given in every combination;.

P4121 Van Put,D.J.M., Van Osselaer,N., De Meyer,G.R.Y., Andries,L.J., Kockx,M.M., De Clerck,L.S., Bult,H. Role of polymorphonuclear leukocytes in collar-induced intimal thickening in the rabbit carotid artery. Arterioscler.Thromb.Vasc.Biol. 1998; 18(--):915-921. >>> Colony-stimulating factor, G; SC; rabbit; 2ML2; 14 days; controls received mp w/5% glucose; immunology; peptides; cardiovascular.

P4080 Kokai,Y., Kaneko,H., Izuka,K., Matsuura,A., Fujimoto,J. Inhibition of resistance to hemopoietic allografts in granulocyte colony-stimulating factor transgenic mice. Eur.J.Immunol. 1996; 26(--):115-119. >>> Colony-stimulating factor, G; mice; 2002; 2 weeks; comparison of sc injections vs mp; immunology; peptides; transplantation; recomb. human G-CSF used.

P3598 Iizuka,K., Kaneko,H., Yamada,T., Kimura,H., Kokai,Y., Fujimoto,J. Host F1 mice pretreated with granulocyte colony-stimulating factor accept parental bone marrow grafts in hybrid resistance system. Blood 1997; 89(-4-):1446-1451. >>> Colony-stimulating factor, G; SC; mice; 2002; 14 days; immunology; peptides.

P3103 Vallera,D.A., Taylor,P.A., Aukerman,S.L., Blazar,B.R. Antitumor protection from the murine T-cell leukemia/lymphoma EL4 by the continuous subcutaneous coadministration of recombinant macrophage-colony stimulating factor and interleukin-2. Cancer Res. 1993; 53(--):4273-4280. >>> Colony-stimulating factor, M; Interleukin-2; Colony-stimulating factor, G; SC; mice; no duration posted; controls received mp with PBS; cancer; immunology; peptides; M-CSF + IL-2 given concomitantly provided best antitumor protection; recomb. IL-2 used; human G-CSF used.

P2546 de Haan,G., Engel,C., Dontje,B., Loeffler,M., Nijhof,W. Hemotoxicity by prolonged etoposide administration to mice can be prevented by simultaneous growth factor therapy. Cancer Res. 1995; 55(--):324-329. >>> Erythropoietin; Colony-stimulating factor, G; Etoposide; SC; mice; 7 days; dose-response curves (pg. 326-328); cancer; peptides; etoposide is VP-16-213; EPO and VP-16-213 given in same pump initially, but this inactived the G-CSF; multiple pumps per animal (1-2) for G-CSF/VP-16 mice.

P1155 Monroy,R.L., Skelly,R.R., MacVittie,T.J., Davis,T.A., Sauber,J.J., Clark,S.C., Donahue,R.E. The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow. Blood 1987; 70(-5-):1696-1699. >>> Colony-stimulating factor, G.; Saline; SC; monkey; 2ML1; 7 days; controls received mp w/ saline; interesting study; peptides.

P0993 Cohen,A.M., Zsebo,K.M., Inoue,H., Hines,D., Boone,T.C., Chazin,V.R., Tsai,L., Ritch,T., Souza,L.M. In vivo stimulation of granulopoiesis by recombinant human granulocyte colony-stimulating factor. Proc.Natl.Acad.Sci. 1987; 84(-8-):2484-2488. >>> Colony-stimulating factor, G; NaOAc; Saline; IV (jugular); hamster; 2001; no duration posted; controls received mp w/vehicle; mp connected to catheter in jugular; half-life data; peptides; comparison of iv injections vs. mp infusion; immunology.

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5. Colony-stimulating Factor, GM

Q0753 Driessens,G., Nuttin,L., Gras,A., Maetens,J., Mievis,S., Schoore,M., Velu,T., Tenenbaum,L., Preat,V., Bruyns,C. Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery. CANCER IMMUNOLOGY IMMUNOTHERAPY 2011; 60(-2-):273-281. >>> Colony-stimulating factor, GM; SC; Rat; 2004; 28 days; Animal info (male, inbred, Fischer 344, 10-12 wks old); comparison of "all in-vivo therapy" vs mp; cancer.

P9201 Driessens,G., Hamdane,M., Cool,V., Velu,T., Bruyns,C. Highly Successful Therapeutic Vaccinations Combining Dendritic Cells and Tumor Cells Secreting Granulocyte Macrophage Colony-stimulating Factor. Cancer Research 2004; 64(--):8435-8442. >>> Colony-stimulating factor, GM, recomb. mouse; SC; Rat; 2004; 4 weeks; Cancer; animal info (male, Fischer 344, 10-12 wks old).

P9099 Grabbe,S., Gallo,R.L., Lindgren,A., Granstein,R.D. Deficient antigen presentation by Langerhans cells from athymic (nu/nu) mice. Restoration with thymic transplantation or administration of cytokines. J.Immunol. 1993/10/1; 151(-7-):3430-3439. >>> Colony-stimulating factor, GM, murine; tumor necrosis factor-a, recomb. mouse; interleukin-1a, recomb. human; PBS; IP; Mice (nude); 2002; 10 days; Controls received mp w/ normal saline; immunology; peptides; animal info (BALB/c, athymic, nu/nu, euthymic, 2-4 wks old).

P8510 Djalilian,H.R., Caicedo,E., Lessan,K., Grami,V., Le,C.T., Spellman,S.R., Pambuccian,S., Hall,W.A., Low,W.C., Ondrey,F.G. Efficacy of an osmotic pump delivered, GM-CSF-based tumor vaccine in the treatment of upper aerodigestive squamous cell carcinoma in rats. CANCER IMMUNOLOGY IMMUNOTHERAPY 2007; 56(-8-):1207-1214. >>> Colony-stimulating factor, GM, murine; interleukin-12; PBS; SC; Rat; 28 days; Controls received mp w/ vehicle; dose-response (fig 1); no stress (see pg. 1209); cancer (upper aerodigestive tract carcinoma); peptides; animal info (Fisher 344, 125-150 g); good methods; "This latter method (mp) has several advantages. First, the use of minipumps obviates the cumbersome need to transfect tumor cells and completely characterize their cytokine repertoires. Second, it allows for independent and rigorous control over the kinetics of administration of cytokine and antigen dosages. Third, it may generate les controversy than those techniques requiring "gene therapy" IRB approval." (p. 1213)..

P7959 Kamel-Reid,S, Dick,J.E. Engraftment of Immune-Defficient Mice with Human Hematopoietic Stem Cells. Science 1988; 242(-4886-):1706-1709. >>> Interleukin-3, human; colony-stimulating factor, GM, human; SC; Mice; mice (SCID); 4-5 weeks; 15 days; Controls received mp w/ saline; peptides; immunology.

P7935 Chen,J.C., Chen,Y., Wu,J.M., Su,Y.H., Tai,K.F., Tseng,S.H. Effects of irradiated tumor vaccine and infusion of granulocyte-macrophage colony-stimulating factor and interleukin-12 on established gliomas in rats. CANCER IMMUNOLOGY IMMUNOTHERAPY 2006; 55(-7-):873-883. >>> Colony-stimulating factor, GM, recomb. mouse; interleukin-12, recomb. mouse; BSA; PBS; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle or no treatment; cancer (RT-2 glioma); peptides; animal info (Fischer, 200-350 grams, SC and ICV tumors); "continuously infused cytokine using an osmotic mini pump to...avoid the side effects of a single large dose of cytokine and one with a concept similar to that of gene-therapy." (p. 874).

P6717 Molineux,G., Hartley,C., McElroy,P., McCrea,C., Kerzic,P., McNiece,I. An analysis of the Effects of Combined Treatment with rmGM-CSF and PEG-rHuMGDF in Murine Bone Marrow Transplant Recipients. Stem Cells 1997; 15(--):43-49. >>> MegaKaryocyte growth development factor, PEG-recomb. human; colony-stimulating factor, GM, recomb. murine; PBS; BSA; SC; Mice; 2002; 18 days; Controls received mp w/ vehicle; dose-response (fig.1); immunology; "To avoid potential scheduling problems in these experiments we have delivered rmGM-CSF by continuous s.c. infusion" (p.44).

P6450 Jean,W.C., Spellman,S.R., Wallenfriedman,M.A., Flores,C.T., Kurtz,B.P., Hall,W.A., Low,W.C. Effects of combined granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2, and interleukin-12 based immunotherapy against intracranial glioma in the rat. Journal of Neuro-oncology 2004; 66(-1-2-):39-49. >>> Colony-stimulating factor, GM; interleukin-2; interleukin-12; SC; Rat; 2004; 4 weeks; Cancer (gliosarcoma); GM-CSF was infused alone or with cytokines.

P5531 Chen,Y., Lin,S.M., Lai,H.S., Tseng,S.H., Chen,W.J. Effects of irradiated tumor vaccine and continuous localized infusion of granulocyte-macrophage colony-stimulating factor on neuroblastomas in mice. Journal of Pediatric Surgery 2002; 37(-9-):1298-1304. >>> Colony-stimulating factor, GM; PBS; BSA; SC (tumor vaccine injection site); Mice; 1002; 14 days; Controls received mp w/ PBS; immunology; GM-CSF is recombinant murine; tissue perfusion.

P5093 Basak,Saroj K., Dubinett,Steven M., Harui,Airi, Mitani,Kohnosuke, Roth,Michael D., Sharma,Sherven, Stolina,Marina. Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4. Blood 2002; 99(-8-):2869-2879. >>> Interleukin-4; Colony-stimulating factor, GM; Saline; SC; mice; 1007D; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum levels via ELISA; immunology; peptides; recombinant cytokines; agents administered singly or concomitantly.

P4649 Wallenfriedman,M.A., Conrad,J.A, DelaBarre,L, Graupman,P.C, Lee,G, Garwood,M, Gregerson,D.S, Jean,W.C., Hall,W.A., Low,W.C. Effects of continuous localized infusion of granulocyte-macrophage colony-stimulating factor and inoculations of irradiated glioma cells on tumor regression.. J.Neurosurg. 1999; 90(--):1064-1071. >>> Colony-stimulating factor, GM;; Saline; BSA; PBS;; SC;; rat;; 2004;; 28 days;; Controls received mp w/ saline; does-response; cancer; immunology; peptides; recomb. murine colony-stimulating factor, GM used..

P4525 Iversen,P.O, Lewis,I.D, Turczynowicz,S, Hasle,H., Niemeyer,C, Schmiegelow,K, Bastiras,S, Biondi,A, Hughes,T.P, Lopez,A.F. Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice.. Blood 1997/12/15; 90(-12-):4910-4917. >>> Colony-stimulating factor, GM; Antibody, monoclonal anti-TNFa;; Saline, isotonic;; IP;; Mice (nude);; 4 weeks;; controls received mp w/vehicle; functionality of mp verified by plasma levels; immunology; peptides;.

P4130 Roelofs,M., Faggian,L., Pampinella,F., Paulon,T., Franch,R., Chiavegato,A., Sartore,S. Transforming growth factor b1 involvement in the conversion of fibroblasts to smooth muscle cells in the rabbit bladder serosa. Histochemical J. 1998; 30(--):393-404. >>> Transforming growth factor-B1; Epidermal growth factor; Fibroblast growth factor, basic; Colony-stimulating factor, G; Platelet-derived growth factor; Colony-stimulating factor, GM; PBS; bladder wall; rabbit; 2ML2; 2ML4; no duration posted; controls received mp w/PBS; no stress (see pg. 395); "a minipump filled with Evans Blue solution was used to determine area of growth factor delivery"; peptides; tissue perfusion (bladder wall).

P3890 Blazar,B.R., Widmer,M.B., Taylor,P.A., Vallera,D.A. Promotion of murine marrow alloengraftment and hematopoietic recovery across the major histocompatibility barrier by administration of recombinant human interleukin-1a. Blood 1992; 80(-6-):1614-1622. >>> Interleukin-1, alpha; Colony-stimulating factor, GM; PBS; SC; mice; 2002; 14 days; controls received mp w/PBS; immunology; peptides; agents given singly, together, or sequentially; "...for a 14-day administration schedule, continuous subcutaneous administration is favorable." (pg. 1618).

P3434 Alisauskas,R.M., Goldenberg,D.M., Sharkey,R.M., Blumenthal,R.D. Reduction in the duration of myelotoxicity associated with radioimmunotherapy with infusions of the hemoregulatory peptide, HP5b in mice. Int.J.Cancer 1997; 70(--):323-329. >>> HP5b; Interleukin-1; Colony-stimulating factor, GM; PBS; Mercaptoethanol, 2-; NaN3; SC; mice; 1007D; 3, 7, 14 days; cancer; immunology; peptides; HP5b is a hemoregulatory peptide.

P2970 Shibata,T., Kindler,V., Chicheportiche,Y., Vassalli,P., Izui,S. Interleukin 3 perfusion prevents death due to acute anemia induced by monoclonal antierythrocyte autoantibody. J.Exp.Med. 1990; 171(--):1809-1814. >>> Interleukin-3; Colony-stimulating factor, GM; Erythropoietin; PBS; Glycerol; LPS, e. coli; SC; mice; 2002; no duration posted; controls received mp with vehicles +/- LPS; immunology; peptides; recomb. mouse GM-CSF&IL-3 used; recomb. human EPO used.

P2523 Berney,T., Shibata,T., Merino,R., Chicheportiche,Y., Kindler,V., Vassalli,P., Izui,S. Murine autoimmune hemolytic anemia resulting from Fc-gamma receptor-mediated erythrophagocytosis: protection by erythropoietin but not by interleukin-3, and aggravation by granulocyte-macrophage colony-stimulating factor. Blood 1992; 79(-11-):2960-2964. >>> Erythropoietin; Interleukin-3; Colony-stimulating factor, GM; PBS; Glycerol; SC; mice; 2002; 14 days; immunology; peptides.

P2507 Blumenthal,R.D., Sharkey,R.M., Forman,D., Wong,G., Goldenberg,D.M. Cytokine intervention permits dose escalation of radioantibody: an analysis of myelostimulation by bolus versus continuous infusion of IL-1/GM-CSF. Cancer Suppl. 1994; 73(-3-):1083-1092. >>> Colony-stimulating factor, GM; Interleukin-1, alpha; PBS; SC; mice; no duration posted; comparison of injections vs. mp; cancer; immunology.

P2449 Vyalov,S., Desmouliere,A., Gabbiani,G. GM-CSF-induced granulation tissue formation: relationships between macrophage and myofibroblast accumulation. Virchows Archiv B Cell Pathol. 1993; 63(--):231-239. >>> Colony-stimulating factor, GM; Tumor necrosis factor; Platelet-derived growth factor; Saline; SC; rat; 2001; 2-7 days; controls received mp w/ TNF, PDGF or carrier solution; functionality of mp verified upon removal; pump infused GM-CSF to study formation of granulation tissue at infusion site; recomb. murine TNF used.

P1326 Monroy,R.L., Skelly,R.R., Taylor,P., Dubois,A., Donahue,R.E., MacVittie,T.J. Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony-stimulating factor. Exp.Hematol. 1988; 16(--):344-348. >>> Colony-stimulating factor, GM; SC; monkey; 2001; 7 days; dose-response; cancer/immunology; no stress; peptides.

P1250 Sakai,N., Ishii,Y., Shikita,M. Increase in macrophage progenitor cell number in femoral marrow of mice after continuous infusion or repeated injections of a macrophage colony-stimulating factor. J.Pharmaco.Biodyn. 1987; 10(-8-):404-407. >>> Colony-stimulating factor, GM; Endotoxin, E. coli; Saline; IP; mice; 2001; 6 days; controls received mp w/ LPS free isotonic saline; 2 exp.; comparison of ip injections vs. mp infusion; functionality of mp verified.

P0853 Donahue,R.E., Wang,E.A., Stone,D.K., Kamen,R., Wong,G.G., Sehgal,P.K., Nathan,D.G., Clark,S.C. Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature 1986; 321(--):872-875. >>> Colony-stimulating factor, GM; Dextrose; SC; monkey; 2ML1; 1 week; half-life; 1 of 3 experiments using mp.

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6. Colony-stimulating Factor, M

Q0623 Lloyd,S.A., Yuan,Y.Y., Simske,S.J., Riffle,S.E., Ferguson,V.L., Bateman,T.A. Administration of high-dose macrophage colony-stimulating factor increases bone turnover and trabecular volume fraction. JOURNAL OF BONE AND MINERAL METABOLISM 2009; 27(-5-):546-554. >>> Colony-stimulating factor, M; SC; Mice; 28 days; Animal info (male, C57BL/6 J, 7 wks old); comparison of SC injections vs mp; lack of cortical response in both daily injection and pump studies, pg 550.

P3103 Vallera,D.A., Taylor,P.A., Aukerman,S.L., Blazar,B.R. Antitumor protection from the murine T-cell leukemia/lymphoma EL4 by the continuous subcutaneous coadministration of recombinant macrophage-colony stimulating factor and interleukin-2. Cancer Res. 1993; 53(--):4273-4280. >>> Colony-stimulating factor, M; Interleukin-2; Colony-stimulating factor, G; SC; mice; no duration posted; controls received mp with PBS; cancer; immunology; peptides; M-CSF + IL-2 given concomitantly provided best antitumor protection; recomb. IL-2 used; human G-CSF used.

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7. Erythropoetin

Q3518 Jeffers,M.S., Hoyles,A., Morshead,C., Corbett,D., Corbett,D. Epidermal Growth Factor and Erythropoietin Infusion Accelerate Functional Recovery in Combination With Rehabilitation. Stroke 2014; 45(--):185-+. >>> Epidermal Growth Factor; erythropoietin; CSF, artificial; CSF/CNS; Rat; 2001; 14 days; Animal info (male, Sprague Dawley); pumps replaced every 7 days; ischemia (cerebral); behavioral testing (staircase test); pumps removed 7 days after serial implantation;.

Q3269 Wang,Y.F., Cooke,M.J., Sachewsky,N., Morshead,C.M., Shoichet,M.S. Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. JOURNAL OF CONTROLLED RELEASE 2013; 172(-1-):1-11. >>> Epidermal growth factor; erythropoietin; CSF, artificial; CSF/CNS; Mice; 1007D; 14 days; Animal info (male, C57BL6, 9-11 weeks old); EGF-PGF pumps replaced after 7 days with pump filled with ETO; ALZET brain infusion kit 3 used; comparison of epicortical composite vs mp; stress/adverse reaction: "Unlike the ICV catheter/minipump,which causes significant tissue damage, the epicortical composite provides a minimal invasiveness and no tissue damage."(see pg.9); immunology; Pumps implanted 4 days after stroke; BIK implanted same day as stroke;.

Q3130 Wang,G.B., Ni,Y.L., Zhou,X.P., Zhang,W.F. The AKT/mTOR pathway mediates neuronal protective effects of erythropoietin in sepsis. MOLECULAR AND CELLULAR BIOCHEMISTRY 2014; 385(-1-2-):125-132. >>> Erythropoietin, human recombinant; PBS; BSA; SC; Rat; 1 week; Controls received mp w/ vehicle or sham surgery; animal info (Sprague Dawley, 120 days old, 240-280g); behavioral testing (open field exploration, inhibitory avoidance, Morris water maze);.

Q2677 Yamaleyeva,L.M., Guimaraes-Souza,N.K., Krane,L.S., Agcaoili,S., Gyabaah,K., Atala,A., Aboushwareb,T., Yoo,J.J. Cell Therapy with Human Renal Cell Cultures Containing Erythropoietin-Positive Cells Improves Chronic Kidney Injury. STEM CELLS TRANSLATIONAL MEDICINE 2012; 1(-5-):373-383Erythropoietin. >>> Erythropoietin, recomb. human; Saline; IP; Rat (nude); 2ML4; ; Animal info (athymic, male, 10-15 wks old); pump functionality measured via residual volume.

Q2546 Unden,J., Sjoelund,C., Laensberg,J.K., Wieloch,T., Ruscher,K., Romner,B. Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat. BMC NEUROSCIENCE 2013; 14(-;-):U1-U8. >>> Erythropoietin; Saline; IV (jugular); Rat; 2001D; 1003D; 72 hours; Control animals received mp w/ vehicle; animal info (Wistar, male, 300-350 g); silastic tubing used.

Q1294 Reitmeir,R., Kilic,E., Kilic,U., Bacigaluppi,M., ElAli,A., Salani,G., Pluchino,S., Gassmann,M., Hermann,D.M. Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain 2011; 134(-;-):84-99. >>> Erythropoietin; NaCl; CSF/CNS; Mice; 4 weeks; Controls received mp w/ vehicle; animal info (C57Bl6/j, male, 23-25 g, 8-10 wks); ALZET brain infusion kit 3 used; ischemia (focal cerebral).

Q1286 Price,C.D., Yang,Z.J., Karlnoski,R., Kumar,D., Chaparro,R., Camporesi,E.M. Effect of continuous infusion of asialoerythropoietin on short-term changes in infarct volume, penumbra apoptosis and behaviour following middle cerebral artery occlusion in rats. Clinical and Experimental Pharmacology and Physiology 2010; 37(-2-):185-192. >>> Erythropoietin, asialo-; Saline, sterile; SC; Rat; 2001; 4 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-275 g).

Q1055 Erlandsson,A., Lin,C.H.A., Yu,F.G., Morshead,C.M. Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury. Experimental Neurology 2011; 230(-1-):48-57. >>> Epidermal growth factor, recomb. human; erythropoietin; cyclosporine A; CSF/CNS; SC; Mice (NOD/SCID); 1007D; ; Animal info (male, C57/BL6, 8-10 wks old); pumps replaced after 7 days; ALZET brain infusion kit 3 used.

Q0577 Kondo,A., Shingo,T., Yasuhara,T., Kuramoto,S., Kameda,M., Kikuchi,Y., Matsui,T., Miyoshi,Y., Agari,T., Borlongan,C.V., Date,I. Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Brain Research 2009; 1296(-;-):127-136. >>> Erythropoietin, human, recomb.; antibody, anti-EPO; Saline; CSF/CNS; Rat; 6 days; 24 hours; Controls received mp w/ rat serum albumin, or control mouse IgG; animal info (male, Fischer 344, 10-12 wks old, 200-250 g, SLC).

Q0293 Jobst,B.J., Riegger,G.A.J., Griese,D.P. Endothelial Cell Seeding Fails to Prevent Intimal Hyperplasia Following Arterial Injury in the Rat Carotid Model. Cardiovascular Drugs and Therapy 2009; 23(-5-):343-353. >>> Colony-stimulating factor, G, human, recomb.; erythropoietin, human, recomb.; IP; Rat; 2ML1; 48 hours; Controls received mp w/ saline; animal info (male, CD, 250 g, splenectomy).

Q0263 Jing,M., Shingo,T., Yasuhara,T., Kondo,A., Morimoto,T., Wang,F.F., Baba,T., Yuan,W.J., Tajiri,N., Uozumi,T., Murakami,M., Tanabe,M., Miyoshi,Y., Zhao,S.G., Date,I. The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting. Brain Research 2009; 1295(-;-):203-217. >>> Erythropoietin, human, recomb.; Saline; albumin, rat serum; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, 190-210 g).

Q0248 Kolb,B, Morshead,C., Gonzalez,C., Kim,M., Gregg,C., Shingo,T., Weiss,S. Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats. Journal of Cerebral Blood Flow and Metabolism 2007; 27(--):983-997. >>> Erythropoietin; epidermal growth factor; CSF, artificial; CSF/CNS; Rat; 2001; 7, 14 days; Controls received mp w/ vehicle; peptides; animal info (male, Long-Evans, 90-110 days old); ischemia (cerebral); behavioral testing (forelimb assymetry, forelimb inhibition (swimming), reaching); some animals received 7 days EGF.

P9496 Kadota,T., Shingo,T., Yasuhara,T., Tajiri,N., Kondo,A., Morimoto,T., Yuan,W.J., Wang,F.F., Baba,T., Tokunaga,K., Miyoshi,Y., Date,I. Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis. Brain Research 2009; 1254(-;-):120-127. >>> Erythropoietin; Albumin, rat serum; saline; CSF/CNS; Rat; 2001; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 220-250 g.).

P9369 Belayev,L., Khoutorova,L., Zhao,K.L., Davidoff,A.W., Moore,A.F., Cramer,S.C. A novel neurotrophic therapeutic strategy for experimental stroke. Brain Research 2009; 1280(-;-):117-123. >>> Erythropoietin; Saline; IV (femoral); Rat; 2ML1; 3 days; Controls received mp w/ vehicle; animal info (male, Long-Evans, 280-330 g., MCAO).

P9049 Hack,M., Mascha,F.G., Jobst,B.J., Riegger,G.A.J., Griese,D.P. A systemic combination therapy with granulocyte-colony stimulating factor plus erythropoietin aggravates the healing process of balloon-injured rat carotid arteries. Cardiovascular Drugs and Therapy 2008; 22(-5-):351-362. >>> Colony-stimulating factor, G-, recomb. human; erythropoietin; IP; Rat; 2ML1; 7 days; Controls received mp w/ saline; peptides; animal info (male, Sprague Dawley, 300-350 g., splenectomy); "We used implantable osmotic minipumps to guarantee continuous systemic delivery of the tested cytokines over the first even days upon intraperitoneal deposition." pg. 353.

P8932 Oya,S., Yoshikawa,G., Takai,K., Tanaka,J.I., Higashiyama,S., Saito,N., Kirino,T., Kawahara,N. Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia. NeuroReport 2008; 19(-8-):805-810. >>> Epidermal growth factor, recomb. human; fibroblast growth factor-2, recomb. human; insulin-like growth factor I, recomb. human; erythropoietin, recomb. rat; brain-derived neurotrophic factor, recomb. human; DDL4, recomb. mouse; CSF/CNS; Rat; 1003D; 3 days; Ischemia; animal info (male, Wistar, 8wks old, 280-300 g.); bilateral infusion.

P8660 Soliz,J., Gassmann,M., Joseph,V. Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia. JOURNAL OF PHYSIOLOGY-LONDON 2007; 583(-1-):329-336. >>> Erythropoietin receptor, soluble; Phosphate buffer; CSF/CNS; Mice; 1003D; 3 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male C57/BL6, 3 months old, hypoxia).

P8429 Frederiksen,B.L., Caye-Thomasen,P., Lund,S.P., Wagner,N., Asal,K., Olsen,N.V., Thomsen,J. Does erythropoietin augment noise induced hearing loss?. Hearing Research 2007; 223(-1-2-):129-137. >>> Erythropoietin; Ear (round window); Guinea-Pig; 1007D; 1 week; Controls received mp w/ saline; replacement therapy (noise-induced hearing impairment); comparison of acute admin. vs. mp; peptides; animal info (male, Dunkin-Hartley); tissue perfusion (round window); mp primed 6 hours in 37 Celsius saline; correct catheter placement confirmed.

P7614 Malhotra,S., Savitz,S.I., Ocava,L., Rosenbaum,D.M. Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack. Journal of Neuroscience Research 2006; 83(-1-):19-27. >>> Erythropoietin receptor, soluble; PBS; BSA; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (male, Wistar, 200-225 g); MCAO.

P5948 Prass,K., Scharff,A., Ruscher,K., Loewl,D., Muselmann,C., Victorov,I., Kapinya,K., Dirnagl,U., Meisel,A. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003; 34(-8-):1981-1986. >>> Erythropoietin, soluble receptor; PBS; BSA; CSF/CNS; Mice; 1003D; 64 hours; Controls received mp w/ vehicle; peptides; ischemia (cerebral); human EPO used; 0.1%BSA used in vehicle.

P5801 Shingo,T., Sorokan,S.T., Shimazaki,T., Weiss,S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 2001; 21(-24-):9733-9743. >>> Erythropoietin; antibody, rabbit anti-EPO neutralizing; rabbit IgG; Saline; albumin, mouse serum; rat serum; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; peptides; Erythropoietin (EPO) Recomb. Human, antibody&IgG were dissolved in 0.9% saline with 1 mg/ml mouse serum albumin; pump/cannula schematic (p. 9739 fig A).

P4619 Walker,B.R., Resta,T.C, Nelin,L.D. Nitric oxide-dependent pulmonary vasodilation in polycythemic rats. Am.J.Physiol.(Heart Circ.Physiol.) 2000; 279(--):H2382-H2389. >>> Erythropoietin; Saline; rat; 2 weeks; controls received mp w/vehicle; peptides; cardiovascular.

P4291 Roeder,I., de Haan,G., Engel,C., Nijhof,W., Dontje,B., Loeffler,M. Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 1998/5/1; 91(-9-):3222-3229. >>> Interleukin-11; Stem cell factor; Colony-stimulating factor, G; Erythropoietin;; SC;; mice;; 2002; 1007D;; 7 days;; controls received mp w/ saline; functionality of mp verified by pilot studies; no stress (see pg. 3223); peptides; recomb. human interleukin-11, EPO,&G-CSF used; recomb. rat stem cell factor used (pegylated);agents were given in every combination;.

P2970 Shibata,T., Kindler,V., Chicheportiche,Y., Vassalli,P., Izui,S. Interleukin 3 perfusion prevents death due to acute anemia induced by monoclonal antierythrocyte autoantibody. J.Exp.Med. 1990; 171(--):1809-1814. >>> Interleukin-3; Colony-stimulating factor, GM; Erythropoietin; PBS; Glycerol; LPS, e. coli; SC; mice; 2002; no duration posted; controls received mp with vehicles +/- LPS; immunology; peptides; recomb. mouse GM-CSF&IL-3 used; recomb. human EPO used.

P2737 Hoffman,A., Nyska,A., Avramoff,A., Golomb,G. Continuous versus pulsatile administration of erythropoietin (EPO) via the uterus in anemic rats. Int.J.Pharmaceutics 1994; 111(--):197-202. >>> Erythropoietin; intrauterine; rat; 2002; 5 days; controls received intrauterine bolus of saline; replacement therapy (gentamicin-induced anemia); comparison of iv bolus and intrauterine bolus vs. mp; peptides; mp implanted subdermally in abdomen; "administration of drug at a constant rate produces considerably greater biological effect than that observed in the pulsatile mode." (pg. 200); tissue perfusion (uterus); recomb. human EPO used.

P2546 de Haan,G., Engel,C., Dontje,B., Loeffler,M., Nijhof,W. Hemotoxicity by prolonged etoposide administration to mice can be prevented by simultaneous growth factor therapy. Cancer Res. 1995; 55(--):324-329. >>> Erythropoietin; Colony-stimulating factor, G; Etoposide; SC; mice; 7 days; dose-response curves (pg. 326-328); cancer; peptides; etoposide is VP-16-213; EPO and VP-16-213 given in same pump initially, but this inactived the G-CSF; multiple pumps per animal (1-2) for G-CSF/VP-16 mice.

P2523 Berney,T., Shibata,T., Merino,R., Chicheportiche,Y., Kindler,V., Vassalli,P., Izui,S. Murine autoimmune hemolytic anemia resulting from Fc-gamma receptor-mediated erythrophagocytosis: protection by erythropoietin but not by interleukin-3, and aggravation by granulocyte-macrophage colony-stimulating factor. Blood 1992; 79(-11-):2960-2964. >>> Erythropoietin; Interleukin-3; Colony-stimulating factor, GM; PBS; Glycerol; SC; mice; 2002; 14 days; immunology; peptides.

P0016 McGarry,M.P., Styles,B.D. Application of continuous flow osmotic minipumps in the study of hemopoietic regulators. Exp.Hematol. 1978; 6(-10-):809-811. >>> Erythropoietin; SC; Mice; 1701; 7 days; comparison of injections vs. mp infusion; peptides.

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8. Erythropoietin

15817 Eduardo H. Sanchez-Mendoza, Jeismar Carballo, Marines Longart, Dirk M. Hermann, Thorsten R. Doeppner. Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to StudyBrain Reorganization in Pathophysiological Conditions. Journal of Visualized Experiments 2016; 107(--):1-9. >>> Erythropoietin, recombinant human; CSF/CNS; Mice; Controls received mp w/ vehicle; animal info (C57BL6); good methods (Jove Video; picture of pump and implantation pg. 4); ischemia (cerebral); post op. care (Carprofen 4 mg/kg); behavioral testing (rotarod test; hand grip strength); cyanoacrylate adhesive;“In this work we have shown the method of implantation of minipumps with a cannula connected to the skull in order to deliver the plasticity promoting protein rhEpo directly into the ventricle, thus circumventing the BBB.” pg 8; Cannula placement verified via histologic analysis"The are no evident severe tissue alterations based on Nissl staining as compared to the corresponding contralateral area";.

13818 Jeffers, M.S., Hoyles, A., Morshead, C., Corbett, D., Corbett, D. Epidermal Growth Factor and Erythropoietin Infusion Accelerate Functional Recovery in Combination With Rehabilitation. Stroke 2014; 45(--):185-+. >>> Epidermal Growth Factor; erythropoietin; Cerebrospinal fluid, artificial; CSF/CNS; Rat; 2001; Animal info (male, Sprague Dawley); pumps replaced every 7 days; ischemia (cerebral); behavioral testing (staircase test); pumps removed 7 days after serial implantation;.

13569 Wang, Y.F., Cooke, M.J., Sachewsky, N., Morshead, C.M., Shoichet, M.S. Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. JOURNAL OF CONTROLLED RELEASE 2013; 172(-1-):1-11. >>> Epidermal growth factor; erythropoietin; Cerebrospinal fluid, artificial; CSF/CNS; Mice; 1007D; Animal info (male, C57BL6, 9-11 weeks old); EGF-PGF pumps replaced after 7 days with pump filled with ETO; ALZET brain infusion kit 3 used; comparison of epicortical composite vs mp; stress/adverse reaction:"Unlike the ICV catheter/minipump,which causes significant tissue damage, the epicortical composite provides a minimal invasiveness and no tissue damage."(see pg.9); immunology; Pumps implanted 4 days after stroke; BIK implanted same day as stroke;.

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9. Interferon

Q4560 Pereira,L., Medina,R., Baena,M., Planas,A.M., Pozas,E., Pozas,E. IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche. Frontiers in Cellular Neuroscience 2015; 9(--):U1-U10. >>> Interferon, gamma; Saline; CSF/CNS (third ventricle); Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, STAT2 KO or 129S6/SvEv); immunology;.

Q3963 Lee,J., Stanley,J.A., McCracken,J.A., Banu,S.K., Arosh,J.A., Arosh,J.A. Intrauterine Coadministration of ERK1/2 Inhibitor U0126 Inhibits Interferon TAU Action in the Endometrium and Restores Luteolytic PGF(2alpha) Pulses in Sheep. Biology of Reproduction 2014; 91(--):U177-U185. >>> U0126; serum protein, ovine; interferon tau, recombinant ovine; DMSO; Intrauterine (uterine horn); Sheep (ewe); 2ML1; 6 days; Controls received mp w/ vehicle; animal info (female, Suffolk Ovis aries); 3% DMSO used; tissue perfusion (uterine horn); cyanoacrylate adhesive; used cyanoacrylate glue to anchor pump; interferon tau aka IFNT;.

Q3523 Johnson,T.S., Terrell,C.E., Millen,S.H., Katz,J.D., Hildeman,D.A., Jordan,M.B. Etoposide Selectively Ablates Activated T Cells To Control the Immunoregulatory Disorder Hemophagocytic Lymphohistiocytosis. Journal of Immunology 2014; 192(-1-):84-91. >>> Interferon, gamma; Saline; SC; Mice; 7 days; Controls received mp w/ vehicle; animal info (prf -/- or WT, lymphocytic choriomeningitis virus infected); functionality of mp verified by serum levels; immunology; murine model of hemophagocytic lymphohistiocytosis;.

Q2583 Dorniak,P., Welsh,TH Jr, Bazer,F.W., Spencer,T.E. Cortisol and Interferon Tau Regulation of Endometrial Function and Conceptus Development in Female Sheep. Endocrinology 2013; 154(-2-):931-941. >>> Cortisol; PF915275; meloxicam; interferon, tau, recomb. ovine; Ethanol; Intrauterine (uterine horn); Sheep (ewe); 2ML1; ; Control animals received mp w/ vehicle; animal info (mature, rambouillet, female, ewe); 2% ethanol used; vinyl catheter used (0007760); "Our previous studies found that infusion of that amount of IFNT in the uterine lumen each day mimics effects of the conceptus on endometrial expression of hormone receptors and IFNT-stimulated genes during early pregnancy in ewes" pg 932.

Q2394 Kimura,A., Ishida,Y., Inagaki,M., Nakamura,Y., Sanke,T., Mukaida,N., Kondo,T. Interferon-gamma is protective in cisplatin-induced renal injury by enhancing autophagic flux. Kidney International 2012; 82(-10-):1093-1104. >>> Interferon, gamma, recomb. mouse; SC; Mice; 1007D; 7 days; Animal info (BALB/c, male, 8-10 wks old).

Q2057 Dorniak,P., Bazer,F.W., Wu,G.Y., Spencer,T.E. Conceptus-Derived Prostaglandins Regulate Endometrial Function in Sheep. Biology of Reproduction 2012; 87(-1-):U80-U86. >>> Interferon, tau, recomb. ovine; meloxicam; PGE2, ovine serum; PGF2a, ovine serum; PGI2, ovine serum; Ethanol; saline; Intrauterine (uterine horn); Sheep (ewe); 2ML1; 5 days; Controls received mp w/ vehicle; animal info (Mature Rambouillet); tissue perfusion (intrauterine); multiple pumps used (2); enzyme inhibitor (prostaglandin synthase two).

Q2056 Dorniak,P., Welsh,TH Jr, Bazer,F.W., Spencer,T.E. Endometrial HSD11B1 and Cortisol Regeneration in the Ovine Uterus: Effects of Pregnancy, Interferon Tau, and Prostaglandins. Biology of Reproduction 2012; 86(-4-):U106-U115. >>> Interferon, tau, recomb. ovine; meloxicam; PGE2, ovine serum; PGF2a, ovine serum; PGI2, ovine serum; Ethanol; saline; Intrauterine (uterine horn); Sheep (ewe); 2ML1; 7 days; Controls received mp w/ vehicle; animal info (Mature Rambouillet); good methods (pg 2); vinyl tubing used (0007760); 2% ethanol used; enzyme inhibitor (prostaglandin synthase two); tissue perfusion (intrauterine).

Q2040 Li,T.X., Shi,Z.D., Rockey,D.C. Preproendothelin-1 expression is negatively regulated by IFNgamma during hepatic stellate cell activation. American Journal of Physiology-Gastrointestinal and Liver Physiology 2012; 302(-9-):G948-G957. >>> Interferon, gamma; PBS; BSA; Rat; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley).

Q1983 Yuan,Y., Kasar,S., Underbayev,C., Vollenweider,D., Salerno,E., Kotenko,S.V., Raveche,E. Role of microRNA-15a in autoantibody production in interferon-augmented murine model of lupus. MOLECULAR IMMUNOLOGY 2012; 52(-2-):61-70. >>> Interferon, alpha; interferon, gamma; PBS; BSA; SC; Mice; 2006; 16 weeks; Animal info (13 wks old, female, B/W); pumps replaced after 8 weeks; long-term study; stability verified after 8 weeks; "residue IFNs from the pumps at the end of treatment were tested on IFN and IFN responsive cell lines and demonstrated that the in vivo conditions in the pump did not affect bioactivity of both IFNs (data not shown)" pg 63.

Q1724 Tu,S.P., Quante,M., Bhagat,G., Takaishi,S., Cui,G.L., Yang,X.D., Muthuplani,S., Shibata,W., Fox,J.G., Pritchard,D.M., Wang,T.C. IFN-gamma Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis. Cancer Research 2011; 71(-12-):4247-4259. >>> Interferon-gamma; PBS; BSA; Mice (transgenic); 4 weeks; Controls received mp w/ vehicle; animal info (wt B6, IFN-gamma transgenic, 2 mo old).

Q1352 Tang,Y., Desierto,M.J., Chen,J.C., Young,N.S. The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure. Blood 2010; 115(-3-):541-548. >>> Interferon, gamma; SC; Mice; 12 days; Animal info (F1, Tbet -/-).

Q1327 Strickertsson,J.A.B., Dossing,K.B.V., Aabakke,A.J.M., Nilsson,H.O., Hansen,T.V.O., Knigge,U., Kjaer,A., Wadstroem,T., Friis-Hansen,L. Interferon-gamma inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism. WORLD JOURNAL OF GASTROENTEROLOGY 2011; 17(-26-):3117-3125. >>> Interferon, gamma; SC; Mice; 2001; 7 days; Animal info (C57BL6/J).

Q1040 Dorniak,P., Bazer,F.W., Spencer,T.E. Prostaglandins Regulate Conceptus Elongation and Mediate Effects of Interferon Tau on the Ovine Uterine Endometrium. Biology of Reproduction 2011; 84(-6-):1119-1127. >>> Meloxicam; interferon, recomb. ovina, tau; Ethanol; saline; Intrauterine (uterine horn); Sheep (ewe); 2ML1; 7 days; Controls received mp w/ vehicle; animal info (ewe, mature, Rambouillet); cyanoacrylate adhesive; enzyme inhibitor (prostaglandin synthase (PTGS)); vinyl catheter used (0007760); "The Alzet pump was then affixed to the mesometrial ligament between the uterine horn and oviduct by using cyanoacrylate glue... and then secured by sewing the oviduct to the perimetrium of the uterine horn, using 0 coated polyglactin suture." pg 1120; 2% ethanol used; photo of pump and catheter placement, fig. 1; "Intrauterine infusion of that amount of IFNT mimics effects of the conceptus on endometrial expression of hormone receptors and IFNT-stimulated genes during early pregnancy in ewes." pg 1120.

Q0408 Ryu,H.J., Kim,J.E., Kim,M.J., Kwon,H.J., Suh,S.W., Song,H.K., Kang,T.C. THE PROTECTIVE EFFECTS OF INTERLEUKIN-18 AND INTERFERON-gamma ON NEURONAL DAMAGES IN THE RAT HIPPOCAMPUS FOLLOWING STATUS EPILEPTICUS. Neuroscience 2010; 170(-3-):711-721. >>> Antibody, anti IL-18; IL-18, recomb. rat; interferon, gamma, recomb. rat; antibody, anti interferon, gamma; IL-18 receptor antagonist; interferon, gamma, receptor antagonist; Saline; CSF/CNS; Rat; 1007D; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 7 wks old); ALZET brain infusion kit 1 used.

P9920 Bott,R.C., Ashley,R.L., Henkes,L.E., Antoniazzi,A.Q., Bruemmer,J.E., Niswender,G.D., Bazer,F.W., Spencer,T.E., Smirnova,N.P., Anthony,R.V., Hansen,T.R. Uterine Vein Infusion of Interferon Tau (IFNT) Extends Luteal Life Span in Ewes. Biology of Reproduction 2010; 82(-4-):725-735. >>> Interferon-tau, recomb, ovine; IV (uterine vein); Sheep (ewe); 2001D; 2ML1; 7 days; 24 hours; Controls received mp w/BSA or sham surgeries; animal info (white-faced, western range ewe); cyanoacrylate adhesive.

P9580 Tzima,S., Victoratos,P., Kranidioti,K., Alexiou,M., Kollias,G. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. Journal of Experimental Medicine 2009; 206(-5-):1167-1179. >>> Interferon-beta, recomb. human; Mice; 2002; 14 days; Animal info (Hmox1 KO).

P9300 Shinohara,A., Koyanagi,S., Hamdan,A.M., Matsunaga,N., Aramaki,H., Ohdo,S. Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function. LIFE SCIENCES 2008; 83(-15-16-):574-580. >>> Interferon-alpha, recomb. human; Saline; SC; Mice; 2001; 6 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; half-life (p. 579) "relatively short"; peptides; animal info (male, ICR, 5 wks old); behavioral testing (locomotor activity).

P8835 Rogers,A.B., Theve,E.J., Feng,Y., Fry,R.C., Taghizadeh,K., Clapp,K.M., Boussahmain,C., Cormier,K.S., Fox,J.G. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Research 2007; 67(-24-):11536-11546. >>> Interferon-gamma, recomb. murine; SC; Mice; 7 days; Controls received mp w/ vehicle; cancer (tumorigenic hepatitis, liver); peptides; animal info (male, female, A/JCr).

P8739 Qiao,X.T., Ziel,J.W., Mckimpson,W., Madison,B.B., Todisco,A., Merchant,J.L., Samuelson,L.C., Gumucio,D.L. Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology 2007; 133(-6-):1989-1998. >>> Interferon-gamma; PBS; BSA; IP; Mice (transgenic); 2, 8, 12 weeks; Controls received mp w/ vehicle; comparison of IP injections vs. mp; peptides; animal info (12.4 KVil-EGFP tg; C57BL/6J; 4 months old); long-term study.

P8261 Si,Y., Ciccone,S., Yang,F.C., Yuan,J., Zeng,D., Chen,S., van de Vrugt,H.J., Critser,J., Arwert,F., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice. Blood 2006; 108(-13-):4283-4287. >>> Interferon-gamma, mouse; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; no stress (see pg. 4286); immunology; peptides; animal info (C57BL/6).

P7725 Birk,R.Z., Rubinstein,M. IFN-alpha induces apoptosis of adipose tissue cells. Biochemical and Biophysical Research Communications 2006; 345(-2-):669-674. >>> Interferon-a A/D, recomb. human; Saline; SC; Mice; 8 days; Controls received mp w/ vehicle; animal info (C57BL/6, diet-induced obese).

P7447 Kang,W.Q., Rathinavelu,S., Samuelson,L.C., Merchant,J.L. Interferon gamma induction of gastric mucous neck cell hypertrophy. LABORATORY INVESTIGATION 2005; 85(-5-):702-715. >>> Interferon-gamma, recomb. mouse; IP; Mice; 1002; 14 days; Controls received PBS; animal info (c57BL/6).

P7184 Mathian,A., Weinberg,A., Gallegos,M., Banchereau,J., Koutouzov,S. IFN-alpha induces early lethal lupus in preautoimmune (New Zealand black x New Zealand White)F1 but not in BALB/c mice1. Journal of Immunology 2005; 174(-5-):2499-2506. >>> Interferon, mouse; PBS; BSA; SC; Mice; 1002; 8-10 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 2 weeks; immunology.

P7132 Brooling,J.T., Campbell,J.S., Mitchell,C., Yeoh,G.C., Fausto,N. Differential regulation of rodent hepatocyte and oval cell proliferation by interferon gamma. Hepatology 2005; 41(-4-):906-915. >>> Interferon-gamma, recomb. mouse; SC; Mice; 4-6 days; Controls received mp w/ saline; replacement therapy (hepatectomy).

P7042 Li,X.X., Yang,Y.Z., Yuan,J., Hong,P., Freie,B., Orazi,A., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc(-/-) mice. Blood 2004; 104(-4-):1204-1209. >>> Interferon-gamma, murine; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; dose-response (fig. 7); no stress (pg. 1209); stress/adverse reaction: (see pg. 1205) "modest though not significant rise in peripheral white blood cell count" (pg. 1205); "IFN-gamma was overall well tolerated by both WT and Fancc -/- mice." (pg. 1208); hematology.

P6764 Frewert,S., Stockhammer,F., Warschewske,G., Zenclussen,A.C., Rupprecht,S., Volk,H.D., Woiciechowsky,C. Intratumoral infusion of interleukin-1 beta and interferon-gamma; induces tumor invasion with macrophages and lymphocytes in a rat glioma model. Neuroscience Letters 2004; 364(-3-):145-148. >>> Interleukin-1, beta recomb. rat; Interferon-gamma, recomb. rat; Saline, physiological; albumin, human serum; CSF/CNS (intratumoral); Rat; 1003D; 48 hours; Controls received mp w/ vehicle; tissue perfusion (tumor); cancer (glioma).

P6142 Koyanagi,S., Ohdo,S. Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism. MOLECULAR PHARMACOLOGY 2002; 62(-6-):1393-1399. >>> Interferon-alpha; Saline, sterile; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; immunology; peptides.

P6048 Zavros,Y., Rathinavelu,S., Kao,J.Y., Todisco,A., Del Valle,J., Weinstock,J.V., Low,M.J., Merchant,J.L. Treatment of Helicobacter gastritis with IL-4 requires somatostatin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003; 100(-22-):12944-12949. >>> Interleukin-4; interferon-gamma; PBS; IP; Mice; 1007D; 7 days; Controls received mp w/ vehicle; comparison of IP injections vs. IP mp.

P5102 Skovseth,D.K., Yamanaka,T., Brandtzaeg,P., Butcher,E.C., Haraldsen,G. Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice. American Journal of Pathology 2002; 160(-5-):1629-1637. >>> Interferon-gamma; Abdominal wall; mice; 2004; ; tissue perfusion (abdominal wall); immunology; peptides; pump implanted SC, catheter tube perfused matrigel plug in abdominal wall..

P4675 Jander,S, Schroetter,M, Fischer,J, Stoll,G. Differential regulation of microglial keratan sulfate immunoreactivity by proinflammatory cytokines and colony-stimulating factors.. Glia 2000; 30(--):401-410. >>> Interferon-gamma; Tumor necrosis factor-a;; PBS, sterile;; CSF/CNS;; rat;; 1007D;; 6 days;; Controls received mp w/ vehicle; immunology; peptides; ALZET brain infusion kit used; proinflammatory cytokines;.

P4551 Nedelec,B, Dodd,C.M, Scott,P.G, Ghahary,A., Tredget,E.E. Effect of interferon-alpha 2b on guinea pig wound closure and the expression of cytoskeletal proteins in vivo.. Wound Repair and Regeneration 1998/6/1; 6(--):202-212. >>> Interferon-a2b; Saline, sterile; IP; Guinea-pig; 2ML4; 7, 14, 21 days; Controls received mp w/vehicle; wound healing study.

P4477 Voest,E.E, Kenyon,B.M, O'Reilly,M.S, Truitt,G, D'Amato,R.J, Folkman,J. Inhibition of angiogenesis in vivo by interleukin 12.. Journal of the National Cancer Institute 1995; 87(-8-):581-586. >>> Interferon-gamma; Saline; IM; Mice (scid); 2002; ; Controls received mp w/ saline; functionality of mp verified by checking residual volume; comparison of bolus invections vs. mp; cancer; immunology; angiogenesis inhibitor; recomb. murine interferon-gamma used; "... in comparison with bolus injections, continuous intraperitoneal infusion of IFN gamma achieved enhanced inhibition of angiogenesis ..." (p. 585).

P3986 Henke,P.K., Bergamini,T.M., Watson,A.L., Brittian,K.R., Powell,D.W., Peyton,J.C. Bacterial products primarily mediate fibroblast inhibition in biomaterial infection. J.Surg.Res. 1998; 74(--):17-22. >>> Antibody, anti-interferon gamma; Antibody, indomethacin; Antibody, anti-TNFa; Antibody, interleukin 1 alpha; PBS, sterile; ETOH; Indomethacin; SC; mice; 1007D; 7 days; immunology; pump implanted next to Dacron graft; peptides.

P3731 Galbiati,F., Rogge,L., Guery,J.-C., Smiroldo,S., Adorini,L. Regulation of the IL-12 receptor B2 subunit by soluble antigen and IL-12 in vivo. Eur.J.Immunol. 1998; 28(--):209-220. >>> Interleukin-12; Interleukin-2; Lysozyme, hen egg white; Ovalbumin; Interferon-gamma; PBS; Albumin, mouse serum; SC; mice; 2001; 9 days; controls received mp w/ PBS; comparison of ip injections vs. mp; immunology; peptides; agents infused singly or in combination in the same pump; recomb. human IL-2 used; recomb. mouse IFN-gamma used.

P3567 Tsuji-Takayama,K., Harashima,A., Tahata,H., Izumi,N., Nishida,Y., Namba,M., Okuda,Y., Ohta,T., Kurimoto,M. IFN-gamma in combination with IL-3 accelerates platelet recovery in mice with 5-fluorouracil-induced marrow aplasia. J.Interferon and Cytokine Res. 1996; 16(--):447-451. >>> Interferon-gamma; Interleukin-3; Albumin, mouse serum; PBS; SC; mice; 1007D; 7 days; controls received mp w/ vehicle; stability verified after 7 day storage; immunology; peptides; cytokines given singly and together.

P3501 Siesjo,P., Visse,E., Sjogren,H.O. Cure of established, intracerebral rat gliomas induced by therapeutic immunizations with tumor cells and purified APC or adjuvant IFN-gamma treatment. J.Immunol. 1996; 19(-5-):334-345. >>> Interferon-gamma; SC; CSF/CNS; rat; 14 days; cancer; immunology; peptides; ALZET brain infusion kit used.

P3104 Unemori,E.N., Beck,L.S., Lee,W.P., Xu,Y., Siegel,M., Keller,G., Liggitt,H.D., Bauer,E.A., Amento,E.P. Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis. J.Invest.Dermatol. 1993; 101(--):280-285. >>> Relaxin; Interferon-gamma; PBS; SC; rat; mice; 2002; no duration posted; controls received mp with vehicle; immunology; multiple pumps per animal (1-2) for relaxin delivery; polyvinyl alcohol sponges implanted subcutaneously in rats for fibrotic infiltration; intentional capsule formation in mice analyzed.

P3004 Flynn,J.L., Chan,J., Triebold,K.J., Dalton,D.K., Stewart,T.A., Bloom,B.R. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J.Exp.Med. 1993; 178(--):2249-2254. >>> Interferon-gamma; PBS; SC; mice; no duration posted; controls received mp w/ PBS or could endogenously produce IFN; replacement therapy (genetic inability to produce IFN-gamma); comparison of im injections vs. mp; circulating half-life of IFN-gamma in mice is about 1 hour; continuous delivery of IFN-gamma prolonged survival longer than did IFN injections (12 vs. 4 days longer than controls); mouse IFN-gamma used.

P2948 Curfs,J.H.A.J., van der Meide,P.H., Billiau,A., Meuwissen,J.H.E.Th., Eling,W.M.C. Plasmodium berghei: recombinant interferon-y and the development of parasitemia and cerebral lesions in malaria-infected mice. Exp.Parasitology 1993; 77(--):212-223. >>> Interferon-gamma; Saline, isotonic; IP; Mice; mice (nude); 2002; no duration posted; controls were untreated, or treated but uninfected; ". . .daily injection of a bolus of 105 units of IFN-gamma is not lethal, whereas even a lower daily total dose of 2.5 x 104 units of IFN-gamma administered by continuous release is lethally toxic."; only continuous delivery was able to prevent development of cerebral malaria; comparison of ip injections vs. mp; recomb. rat IFN-gamma.

P2935 Rapp,J., Dallah,C.N., Schulz-Key,H. Parenteral administration of cytokines and drugs in rodent filariasis via osmotic pumps. Parasite 1994; 1(-1S-):35-37. >>> Interferon-gamma; SC; mice; 2002; 14 days; controls received mp with PBS or were untreated; no stress (see pg. 37); immunology; "implantation of osmotic pumps is a suitable method for the application of short lived substances like IFN-gamma or other cytokines."; incision heals within three days and animals show no signs of discomfort, making pumps a useful alternative to repeated injections especially for rodents..."; recomb. mouse IFN-gamma used.

P2677 Drath,D.B., Do,C., Burd,T., Hong,L.L. Activation of a distinct subpopulation of pulmonary macrophages following exposure to biological response modifiers. Immunol.Invest. 1994; 23(-2-):115-127. >>> Interferon-gamma; S-MDP, free; S-MDP, liposome-encapsulated; SC; rat; 7 days; comparison of bolus tracheal injections, iv administration and mp; immunology; peptides; IFN-gamma and S-MDP were most effective when delivered either intravenously or via osmotic minipump infusion; S-MDP is lipophilic N-acetylmuramyl-6-0-stearoyl-alanyl-D-isoglutamine; recomb. mouse IFN-gamma used.

P2625 Wiranowska,M., Prockop,L.D., Naidu,A.K., Saporta,S., Kori,S., Kulkarni,A.P. Interferon entry through the blood-brain barrier in glioma and its effect on lipoxygenase activity. Anticancer Res. 1994; 14(--):1121-1126. >>> Interferon-a/B, mouse; Interferon-gamma; SC; mice; 3 days; cancer; peptides; recomb. mouse IFN-gamma used.

P2533 Rockey,D.C., Chung,J.J. Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: implications for treatment of hepatic fibrosis. J.Invest.Med. 1994; 42(-4-):660-670. >>> Interferon-gamma; PBS; Albumin, bovine serum; IP; rat; 2ML4; no duration posted; controls received mp w/ vehicle; immunology; peptides; rat IFN-gamma used.

P2494 Rosiello,R.A., Merrill,W.W., Rockwell,S., Carter,D., Cooper Jr,J.A.D., Care,S., Amento,E.P. Radiation pneumonitis: bronchoalveolar lavage assessment and modulation by a recombinant cytokine. Am.Rev.Respir.Dis. 1993; 148(--):1671-1676. >>> Interferon-gamma; SC; rat; 26 days; peptides; oncology.

P2301 Kuhn,J.A., Wong,J.Y.C., Beatty,B.G., Esteban,J.M., Williams,L.E., Beatty,J.D. Gamma-interferon enhancement of carcinoembryonic antigen expression in human colon carcinoma xenografts. J.Immunother. 1992; 11(--):257-266. >>> Interferon-gamma; Albumin, bovine serum; PBS; SC; mice; 1007D; 3-7 days; functionality of mp verified by residual amounts; dose-response (text p. 259, graph p. 260); comparison of ip injections vs. infusion; cancer; immunology; peptides; biological activity of residual in pump diminished 15% by day 4, 25% by day 6 (p. 262); recomb. human IFN-gamma used.

P2121 Wiranowska,M., Gonzalvo,A.A., Saporta,S., Gonzalez,O.R., Prockop,L.D. Evaluation of blood-brain barrier permeability and the effect of interferon in mouse glioma model. J.Neurooncology 1992; 14(--):225-236. >>> Interferon-a/B, mouse; SC; mice; 1003D; 3 days; cancer; homologous mouse IFN-a/B used.

P1999 Denis,M. Involvement of cytokines in determining resistance and acquired immunity in murine tuberculosis. J.Leukoc.Biol. 1991; 50(--):495-501. >>> Interferon-gamma, inactivated; Tumor necrosis factor-a; Interferon-gamma; Interleukin-2; Interleukin-2, inactivated; Tumor necrosis factor-a, inactivated; IP; mice; 2002; no duration posted; peptides.

P1947 Newton,G.R., Martinod,S., Hansen,P.J., Thatcher,W.W., Siegenthaler,B., Gerber,C., Voirol,M.-J. Effect of bovine interferon on acute changes in body temperature and serum progesterone concentration in heifers. J.Dairy Sci. 1990; 73(--):3439-3448. >>> Interferon-a1; cattle; 2ML1; 5 days; peptides; serum IFN-a levels (p. 3445).

P1918 Granstein,R.D., Deak,M.R., Jacques,S.L., Margolis,R.J., Flotte,T.J., Whitaker,D., Long,F.H., Amento,E.P. The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wound model. J.Invest.Dermatol. 1989; 93(-1-):18-27. >>> Interferon-gamma; PBS; Serum, mouse; IP; SC; mice; 2002; 14 days; peptides; wound healing.

P1845 Denis,M. Recombinant murine beta interferon enhances resistance of mice to systemic mycobacterium avium infection. Infect.Immun. 1991; 59(-5-):1857-1859. >>> Interferon-beta; mice; 2002; no duration posted; controls received pumps with heat-inactivated cytokines; peptides.

P1718 Murray,H.W. Effect of continuous administration of interferon-y in experimental visceral leishmaniasis. J.Infect.Dis. 1990; 161(--):992-994. >>> Stibogluconate, sodium; Interferon-gamma; Albumin, bovine serum; Saline; SC; mice; 2002; 1 week; comparison of ip injections vs. mp; immunology; some mice received 2 pumps.

P1293 Guadagni,F., Schlom,J., Pothen,S., Pestka,S., Greiner,J.W. Parameters involved in the enhancement of monoclonal antibody targeting in vivo with recombinant interferon. Cancer Immunol.Immunother. 1988; 26(--):222-230. >>> Interferon-a, recomb. human; Saline; SC; Mice (nude); 2001; 5-13 days; dose-response (graph); half-life; comparison of i.m. injections vs. mp infusion; functionality of mp verified by plasma levels; cancer/immunology; peptides.

P0987 Granstein,R.D., Murphy,G.F., Margolis,R.J., Byrne,M.H., Amento,E.P. Gamma-interferon inhibits collagen synthesis in vivo in the mouse. J.Clin.Invest. 1987; 79(-4-):1254-1258. >>> Interferon-gamma; PBS; Serum, mouse; SC; mice; 2002; 7-14 days; 2002, 7-14 days; controls received mp w/vehicle; peptides; immunology; stress/adverse reaction (fibrous tissue formation which was used to study effects of gamma-interferon).

P0957 Drath,D.B. Modulation of pulmonary macrophage superoxide release and tumoricidal activity following activation by biological response modifiers. Immunopharmacology 1986; 12(-2-):117-126. >>> Interferon-gamma; Liposomes; SC; rat; 2001; 7 days; controls received mp w/empty liposomes; liposome encapsulated agent and free agent; comparison of iv injections vs. mp infusion; cancer/immunology; peptides.

P0504 Heston,W.D.W., Fleischmann,J., Tackett,R.E., Ratliff,T.L. Effects of a-difluoromethylornithine and recombinant interferon-a2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. Cancer Res. 1984; 44(--):3220-3225. >>> Interferon-a2, recomb. human; SC; Mice (nude); 2002; 4 weeks; pump replaced after 2 weeks; immunotherapy; controls received unidentified vehicle in mp; peptides; cancer; recomb. human IF-a2 used.

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10. Interferons

15995 Hoyo-Becerra, C., Liu, Z., Yao, J., Kaltwasser, B., Gerken, G., Hermann, D. M., Schlaak, J. F. Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-alpha-Related Depression in Hepatitis C Virus Infection. Mol Neurobiol 2015; 52(-1-):318-29. >>> Interferon-a, murine; polyinosinic/polycytidylic acid; PBS; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; animal info (C57BL6J); behavioral testing (open field test; tail suspension test; forced swimming test); polyinosinic/polycytidylic acid is a toll-like receptor-3 agonist; Dose (mIFN-a 250 IU/day; poly(I:C) 1 ug/day);.

15056 Pereira, L., Medina, R., Baena, M., Planas, A.M., Pozas, E., Pozas, E. IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche. Frontiers in Cellular Neuroscience 2015; 9(--):U1-U10. >>> Interferon, gamma; Saline; CSF/CNS (third ventricle); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, STAT2 KO or 129S6/SvEv); immunology;.

14264 Lee, J., Stanley, J.A., McCracken, J.A., Banu, S.K., Arosh, J.A., Arosh, J.A. Intrauterine Coadministration of ERK1/2 Inhibitor U0126 Inhibits Interferon TAU Action in the Endometrium and Restores Luteolytic PGF(2alpha) Pulses in Sheep. Biology of Reproduction 2014; 91(--):U177-U185. >>> U0126; serum protein, ovine; interferon tau, recombinant ovine; DMSO; Intrauterine (uterine horn); Sheep (ewe); 2ML1; Controls received mp w/ vehicle; animal info (female, Suffolk Ovis aries); 3% DMSO used; tissue perfusion (uterine horn); cyanoacrylate adhesive; used cyanoacrylate glue to anchor pump; interferon tau aka IFNT;.

13823 Johnson, T.S., Terrell, C.E., Millen, S.H., Katz, J.D., Hildeman, D.A., Jordan, M.B. Etoposide Selectively Ablates Activated T Cells To Control the Immunoregulatory Disorder Hemophagocytic Lymphohistiocytosis. Journal of Immunology 2014; 192(-1-):84-91. >>> Interferon, gamma; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (prf -/- or WT, lymphocytic choriomeningitis virus infected); functionality of mp verified by serum levels; immunology; murine model of hemophagocytic lymphohistiocytosis;.

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11. Interleukin-1

16146 Okizaki, S., Ito, Y., Hosono, K., Oba, K., Ohkubo, H., Kojo, K., Nishizawa, N., Shibuya, M., Shichiri, M., Majima, M. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1beta by Recruited Macrophages. Am J Pathol 2016; 186(-6-):1481-98. >>> Placenta growth factor, recombinant human; antibody, interleukin-1B; PBS; SC; Mice; 1007D; Controls received mp w/ vehicle or control antibody; animal info (male, C57BL6, 8 weeks old, STZ); immunology; diabetes; Dose (PlGF 10 ug/mouse; anti-IL-1B 1 ug/day);.

16068 Wu, K. L., Wu, C. W., Chao, Y. M., Hung, C. Y., Chan, J. Y. Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation. Free Radic Biol Med 2016; 97(--):58-74. >>> Endotoxin, LPS; coenzyme Q10; temple; Interleukin-1, receptor antagonist; butylhydroquinone, tert-; Saline; CSF, artificial; IP; CSF/CNS (cisterna magna); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 8 weeks old, 250-280g); ALZET brain infusion kit 2 used; post op. care (IM procaine Penicillin 1000 IU); tissue perfusion (cisterna magna); cardiovascular; bp measured using tail cuff; Dose (LPS 1.2 mg/kg/day; coenzyme Q10 3.25 ug/ul/hr; tempol 5 ug/ul/hr; IL-1Ra 0.5 ug/ul/h);.

15955 Liu, Q., Wang, T., Yu, H., Liu, B., Jia, R. Interaction between interleukin-1 beta and angiotensin II receptor 1 in hypothalamic paraventricular nucleus contributes to progression of heart failure. J Interferon Cytokine Res 2014; 34(-11-):870-5. >>> Losartan; interleukin-1, beta; CSF, articifial; CSF, artificial; CSF/CNS; rats; 2004; Controls: sham rats w/ no treatment; rats given artificial CSF; animal info (Male Sprague–Dawley rats, 200–250 g); functionality of mp verified by echocardiography and plasma levels; bilateral cannula used; Plastics One double cannula; cardiovascular; heart failure; brain tissue distribution; Cannula placement verified via brain coordinates; LOS aka losartan; IL-1B aka interleukin-1B; Dose: LOS 200ug/day, IL-1B 1ug/day; Resultant plasma level (pg 872-874); Brain coordinates; pg. 871 (2.0mm posterior to the bregma and 8.5mm ventral from the skull surface).

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12. Interleukin-2

14441 Tilahun, A.Y., Chowdhary, V.R., David, C.S., Rajagopalan, G., Rajagopalan, G. Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome. Journal of Immunology 2014; 193(--):2919-2930. >>> Interleukin-2, murine; antibody, anti-interleukin-2; PBS; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (HLA-DR3); comparison of injection vs mp; immunology;.

12899 Katz, S.C., Burga, R.A., Naheed, S., Licata, L.A., Thorn, M., Osgood, D., Nguyen, C.T., Espat, N.J., Fletcher, J.A., Junghans, R.P. Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor. Journal of Translational Medicine 2013; 11(-;-):U1-U10. >>> Interleukin-2, human; SC; Mice (nude); Animal info (6 wks old, male, Nu/J); 7-day pumps used.

11560 Quiel, J., Caucheteux, S., Laurence, A., Singh, N.J., Bocharov, G., Ben-Sasson, S.Z., Grossman, Z., Paul, W.E. Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011; 108(-8-):3312-3317. >>> Interleukin-2; interleukin-7; interleukin-15; SC; Mice; 2001; Controls received mp w/ PBS; animal info (6-12 wks old, gender, age matched); immunology.

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13. Interleukin-3

13285 Rao, K.N., Smuda, C., Gregory, G.D., Min, B., Brown, M.A. Ikaros limits basophil development by suppressing C/EBP-alpha expression. Blood 2013; 122(-15-):2572-2581. >>> Interleukin-3; SC; Mice; Animal info (C57BL/6:SV129 IK-/-).

11060 Kim, S., Shen, T., Min, B. Basophils Can Directly Present or Cross-Present Antigen to CD8 Lymphocytes and Alter CD8 T Cell Differentiation into IL-10-Producing Phenotypes. Journal of Immunology 2009; 183(-5-):3033-3039. >>> Interleukin-3; Mice (transgenic); Animal info (C57BL/6, OT-I TCR-transgenic, IL-4KO B6); immunology.

10003 Yoshimoto, T., Yasuda, K., Tanaka, H., Nakahira, M., Imai, Y., Fujimori, Y., Nakanishi, K. Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. NATURE IMMUNOLOGY 2009; 10(-7-):706-U54. >>> Interleukin-3; PBS; SC; Mice; Animal info (DO11.10, IL-4 deficient).

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14. Interleukin-4

16169 Sato, T., Pajarinen, J., Behn, A., Jiang, X., Lin, T. H., Loi, F., Yao, Z., Egashira, K., Yang, F., Goodman, S. B. The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis. J Biomed Mater Res A 2016; 104(-9-):2255-62. >>> Ultra-high molecular weight polyethylene particles; interleukin-4, mouse recombinant; BSA; PBS; Bone (femur); Mice; 2006; Controls received mp w/ vehicle; animal info (male, BALB/cByJ, 10-12 weeks old); 1% BSA used; post op. care (buprenorphine injection SC); used vinyl tubing to connect pumps to titanium rods;.

14338 Pajarinen, J., Tamaki, Y., Antonios, J.K., Lin, T.H., Sato, T., Yao, Z.Y., Takagi, M., Konttinen, Y.T., Goodman, S.B., Goodman, S.B. Modulation of mouse macrophage polarization in vitro using IL-4 delivery by osmotic pumps. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2015; 103(--):1339-1345. >>> Interleukin-4, mouse recombinant; BSA; PBS; In vitro; 2006; 1% BSA used; immunology;"Osmotic pumps delivered IL-4 at a rate that closely followed the expected delivery rate."pg 1343; used vinyl tubing; pumps lead into mouse bone marrow macrophage augmented media; incubated at 37C.

10832 Milner, J.D., Orekov, T., Ward, J.M., Cheng, L., Torres-Velez, F., Junttila, I., Sun, G.P., Buller, M., Morris, S.C., Finkelman, F.D., Paul, W.E. Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation. Blood 2010; 116(-14-):2476-2483. >>> Interleukin-4, recomb. mouse; interleukin-13 recomb. mouse; SC; Mice; Controls received mp w/ PBS; animal info (C57BL6, b6 Rag2 -/-, b6 Stat6 -/-); 100 ul sized pump used; immunology.

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15. Interleukin-5

14659 Amaral, L.M., Kiprono, L., Cornelius, D.C., Shoemaker, C., Wallace, K., Moseley, J., Wallukat, G., Martin, JN Jr, Dechend, R., LaMarca, B., LaMarca, B. Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy. American Journal of Obstetrics and Gynecology 2014; 211(--):U377-U382. >>> Interleukin-5, recombinant rat; Rat (pregnant); 2002; Controls received mp w/ vehicle; animal info (pregnant, 14-19 days gestation); cardiovascular; bp measured using catheter; preeclampsia;.

5411 Mishra, A., Hogan, S.P., Brandt, E.B., Rothenberg, M.E. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol 2002; 168(-5-):2464-2469. >>> Interleukin-5; PBS; BSA; IP; Mice (transgenic); 2001; Controls received mp w/ vehicle; Immunology; peptides; human IL-5 used.

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16. Interleukin-6

16061 Wang, S., Wang, L., Dou, L., Guo, J., Fang, W., Li, M., Meng, X., Man, Y., Shen, T., Huang, X., Li, J. MicroRNA 152 regulates hepatic glycogenesis by targeting PTEN. FEBS J 2016; 283(-10-):1935-46. >>> Interleukin-6; Mice; animal info (male, C57Bl6J, 12 weeks old); diabetes;.

15982 Iwayanagi, Y., Igawa, T., Maeda, A., Haraya, K., Wada, N. A., Shibahara, N., Ohmine, K., Nambu, T., Nakamura, G., Mimoto, F., Katada, H., Ito, S., Tachibana, T., Jishage, K., Hattori, K. Inhibitory FcgammaRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering. J Immunol 2015; 195(-7-):3198-205. >>> Interleukin-6R, human soluble; SC; Mice (transgenic); animal info (WT or hFcRn Tg); functionality of mp verified by plasma levels;.

15765 Nardhy Gomez-Lopez, David M Olson, Sarah A Robertson. Interleukin-6 controls uterine Th9 cells and CD8+ T regulatory cells to accelerate parturition in mice. immunology and Cell Biology 2016; 94(--):79-89. >>> Interleukin-6, recombinant human;; PBS; BSA; SC; Mice (pregnant); 1007D; Controls received mp w/ vehicle; animal info (female, pregnant, Il6 +/+ or Il6 -/-, 11.5 dpc, 8-12 weeks old); 0.1% BSA used; immunology; Dose (5 ng/h);.

14924 Dou, L., Meng, X.Y., Sui, X.F., Wang, S.Y., Shen, T., Huang, X.Q., Guo, J., Fang, W.W., Man, Y., Xi, J.Z., Li, J., Li, J. MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes. SCIENTIFIC REPORTS 2015; 5(--):U1-U11. >>> Interleukin-6; NaCl; BSA; SC; Mice; 2001; Animal info (male, C57BL6J, 12 weeks old); 0.1% BSA used; immunology;.

1657 Takatsuki, F., Okano, A., Suzuki, C., Miyasaka, Y., Hirano, T., Kishimoto, T., Ejima, D., Akiyama, Y. Interleukin 6 perfusion stimulates reconstitution of the immune and hematopoietic systems after 5-fluorouracil treatment. Cancer Res 1990; 50(--):2885-2890. >>> Interleukin-6; PBS; SC; mice; 2001; comparison of sc injections vs. mp; pumps employed due to short in vivo half-life of IL-6:'Slowly released IL-6 using a mini-osmotic pump succeeded in maintaining a constant serum-level of IL-6, and this administration was more effective than a daily s.c; cancer.

1565 Suzuki, C., Okano, A., Takatsuki, F., Miyasaka, Y., Hirano, T., Kishimoto, T., Ejima, D., Akiyama, Y. Continuous infusion with interleukin 6 (IL-6) enhances production of hematopoietic stem cells (CFU-S). Biochem. Biophys. Res. Commun 1989; 159(-3-):933-938. >>> Interleukin-6; PBS; Serum, mouse; mice; 2001; controls received pumps filled with mouse serum containing human serum albumen; functionality of mp verified by monitoring IL-6 levels in serum;dose-response (graph); 1% v/v mouse serum in drug solution, paper states'using osmotic pump, succeeded in main.

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17. Interleukin-7

12029 Palmer, M.J., Mahajan, V.S., Chen, J.Z., Irvine, D.J., Lauffenburger, D.A. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naive CD8(+) T cells. Immunology and Cell Biology 2011; 89(-5-):581-594. >>> Interleukin-7; SC; Mice; 1007D; Controls received mp w/ PBS; animal info (C57BL/6, 6-16 wks old); wound clips used; post op. care (betadine).

11560 Quiel, J., Caucheteux, S., Laurence, A., Singh, N.J., Bocharov, G., Ben-Sasson, S.Z., Grossman, Z., Paul, W.E. Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011; 108(-8-):3312-3317. >>> Interleukin-2; interleukin-7; interleukin-15; SC; Mice; 2001; Controls received mp w/ PBS; animal info (6-12 wks old, gender, age matched); immunology.

10175 Park, J.H., Adoro, S., Guinter, T., Erman, B., Alag, A.S., Catalfamo, M., Kimura, M.Y., Cui, Y.Z., Lucas, P.J., Gress, R.E., Kubo, M., Hennighausen, L., Feigenbaum, L., Singer, A. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. NATURE IMMUNOLOGY 2010; 11(-3-):257-U10. >>> Interleukin-7, recomb, mouse; SC; Mice; Animal info (79Z); immunology.

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18. Interleukin-8

15610 Plata-Salaman, C.R., Sonti, G., Borkoski, J.P., Wilson, C.D., ffrench-Mullen, J.M.H. Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol. Behav 1996; 60(-3-):867-875. >>> Interleukin-1 receptor antagonist; Interleukin-6; Interleukin-1, beta heat inactivated; Interleukin-8; Interleukin-1, beta; Tumor necrosis factor-a; Saline, sterile physiological; BSA; CSF/CNS; rat; 2001; controls received mp w/vehicle; guide cannula was used, and a sterile 29 g stainless steel obturator was used to ensure cannula patency during at least a 10 day recovery period after surgery; BSA added as stabilizing agent and carrier protein for cytokines; recomb. human IL-6&8 used.

4199 Plata-Salaman, C.R., Sonti, G., Borkoski, J.P., Wilson, C.D., ffrench-Mullen, J.M.H. Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol. Behav 1996; 60(-3-):867-875. >>> Interleukin-1 receptor antagonist; Interleukin-6; Interleukin-1, beta heat inactivated; Interleukin-8; Interleukin-1, beta; Tumor necrosis factor-a; Saline, sterile physiological; BSA; CSF/CNS; rat; 2001; controls received mp w/vehicle; guide cannula was used, and a sterile 29 g stainless steel obturator was used to ensure cannula patency during at least a 10 day recovery period after surgery; BSA added as stabilizing agent and carrier protein for cytokines; recomb. human IL-6&8 used.

3829 Garin, E.H., West, L., Zheng, W. Effect of interleukin-8 on glomerular sulfated compounds and albuminuria. Pediatric Nephrology 1997; 11(--):274-279. >>> Interleukin-8; BSA; IA (renal); rat; 2ML1; controls received mp w/BSA; good methods (pg. 275); peptides; used PE-10 catheter stretched to further reduce its diameter.

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19. Interleukin-10

15791 Victor V. Lima, Saiprasad M. Zemse, Chin-Wei Chiaoc,, Gisele F. Bomfimd,, Rita C. Tostes, R. Clinton Webb, Fernanda R. Giachini. Interleukin-10 limits increased blood pressure and vascular RhoA/Rho-kinase signaling in angiotensin II-infused mice. Life Sci 2016; 145(--):137-143. >>> Angiotensin II; interleukin-10, recombinant mouse;; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, IL-10 -/- or WT, 10-12 weeks old); functionality of mp verified by plasma levels; immunology; bp measured using catheter; Dose (Ang II 90 ng/min; IL-10 0.5 ng/min);.

13657 Perez-Asensio, F.J., Perpina, U., Planas, A.M., Pozas, E. Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain. Journal of Cell Science 2013; 126(-18-):4208-4219. >>> Interleukin-10; U0126; Saline; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (IL-10 KO); immunology;.

11928 Gotoh, K., Inoue, M., Masaki, T., Chiba, S., Shimasaki, T., Ando, H., Fujiwara, K., Katsuragi, I., Kakuma, T., Seike, M., Sakata, T., Yoshimatsu, H. A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced hypothalamic inflammation. Journal of Neurochemistry 2012; 120(-5-):752-764. >>> Interleukin-10, recomb.; SC; Rat; mice; Controls received mp w/ mouse serum albumin; animal info (C57Bl/6J, IL-10KO; Sprague Dawley, male).

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20. Interleukin-11

14857 Buzzelli, J.N., Pavlic, D.I., Chalinor, H.V., O'Connor, L., Menheniott, T.R., Giraud, A.S., Judd, L.M., Judd, L.M. IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment. ONCOTARGET 2015; 6(--):679-695. >>> Interleukin-11, recombinant human; SC; Mice; 1007D; Controls received mp w/ saline; animal info (WT or IL-1RT1, 12-14 weeks old); immunology;.

6060 Kuenzler, K.A., Pearson, P.Y., Schwartz, M.Z. IL-11 pretreatment reduces cell death after intestinal ischemia-reperfusion. Journal of Surgical Research 2002; 108(-2-):268-272. >>> Interleukin-11; Saline; IV (jugular); Rat; 1003D; Controls received mp w/ vehicle; peptides; IL-11 was human recomb; ischemia (intestinal).

5277 Kuenzler, K.A., Pearson, P.Y., Schwartz, M.Z. Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury. Journal of Pediatric Surgery 2002; 37(--):457-459. >>> Interleukin-11; Saline; IV (jugular); rat; 1003D; controls received mp w/ vehicle; peptides; ischemia (bowel).

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21. Interleukin-12

13984 Berg, J.V., Vrohlings, M., Haller, S., Haimovici, A., Kulig, P., Sledzinska, A., Weller, M., Becher, B. Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection. Journal of Experimental Medicine 2013; 210(-13-):2803-2811. >>> Interleukin-12, murine; PBS; CSF/CNS (intratumoral); Mice; 1004; 2004; Controls received mp w/ vehicle; animal info (C57BL6); cancer (glioma); tissue perfusion (tumor; glioma); immunology; pumps primed at 37C; pumps explanted after 28 days;.

13401 Krejsa, C.M., Holly, R.D., Heipel, M., Bannink, K.M., Johnson, R., Roque, R., Heffernan, J., Hill, J., Chin, L., Wagener, F., Shiota, F., Henderson, K., Sivakumar, P.V., Ren, H.P., Barahmand-pour, F., Foster, D., Clegg, C., Kindsvogel, W., Ponce, R., Hughes, S.D., Waggie, K. Interleukin-21 Enhances Rituximab Activity in a Cynomolgus Monkey Model of B Cell Depletion and in Mouse B Cell Lymphoma Models. PLoS One 2013; 8(-6-):U875-U888. >>> Interleukin-12, recomb. human; Saline; SC; Mice (SCID; NOD/SCID); 2004; Animal info (female, SCID and NOD/SCID, 8-10 weeks old); cancer (Lymphoma);.

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22. Interleukin-13

11613 Shimamura, T., Fujisawa, T., Husain, S.R., Joshi, B., Puri, R.K. Interleukin 13 Mediates Signal Transduction through Interleukin 13 Receptor alpha 2 in Pancreatic Ductal Adenocarcinoma: Role of IL-13 Pseudomonas Exotoxin in Pancreatic Cancer Therapy. Clinical Cancer Research 2010; 16(-2-):577-586. >>> Interleukin-13; PBS; albumin, human serum; IP; Mice (SCID); 1007D; Controls received vehicle injections; animal info (5-6 wks old, male, SCID); comparison of ip injections vs ip mp; cancer (pancreatic);"Compared with (bolus IP) administration of 50 ug/kg IL-13 cytotoxin daily for 7 consecutive days, (ALZET pumps) (infused over 7 days) significantly suppressed tumor growth (P = 0.022) from the beginning of the treatment until the end of the experiment... Compared with the (bolus IP) 50 ug/kg group, a significant prolonged survival time was observed in the (ALZET pump) 50 ug/kg group", pg 581.

11052 Fujisawa, T., Nakashima, H., Nakajima, A., Joshi, B.H., Puri, R.K. Targeting IL-13Ralpha2 in human pancreatic ductal adenocarcinoma with combination therapy of IL-13-PE and gemcitabine. International Journal of Cancer 2011; 128(-5-):1221-1231. >>> Interleukin-13-Pseudomonas exotoxin, recomb.; IP; Mice (nude); Animal info (nu/nu, 5-6 wks old); comparison of IP injections vs IP mp; IL-13-PE is a recombinant immunotoxin;"Mice receiving continuous IL-13-PE exhibited better tumor response compared to bolus administration"pg 1224.

10832 Milner, J.D., Orekov, T., Ward, J.M., Cheng, L., Torres-Velez, F., Junttila, I., Sun, G.P., Buller, M., Morris, S.C., Finkelman, F.D., Paul, W.E. Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation. Blood 2010; 116(-14-):2476-2483. >>> Interleukin-4, recomb. mouse; interleukin-13 recomb. mouse; SC; Mice; Controls received mp w/ PBS; animal info (C57BL6, b6 Rag2 -/-, b6 Stat6 -/-); 100 ul sized pump used; immunology.

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23. Interleukin-15

14928 Garofalo, S., D'Alessandro, G., Chece, G., Brau, F., Maggi, L., Rosa, A., Porzia, A., Mainiero, F., Esposito, V., Lauro, C., Benigni, G., Bernardini, G., Santoni, A., Limatola, C., Limatola, C. Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice. Nature Communications 2015; 6(--):U26-U38. >>> Interleukin-15; brain-derived neurotrophic factor; PBS; CSF/CNS (striatum); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6, 3 weeks or 2 months old); ALZET brain infusion kit 3 used; cancer (glioma, U87MG human); tissue perfusion (right striatum); immunology; pumps primed in 37C saline overnight;.

11560 Quiel, J., Caucheteux, S., Laurence, A., Singh, N.J., Bocharov, G., Ben-Sasson, S.Z., Grossman, Z., Paul, W.E. Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011; 108(-8-):3312-3317. >>> Interleukin-2; interleukin-7; interleukin-15; SC; Mice; 2001; Controls received mp w/ PBS; animal info (6-12 wks old, gender, age matched); immunology.

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24. Interleukin-18

16228 Pazos, P., Lima, L., Tovar, S., Gonzalez-Touceda, D., Dieguez, C., Garcia, M. C. Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Sci Rep 2015; 5(--):17977. >>> Interleukin-18; Saline; CSF/CNS (lateral ventricle); mice; 1007D; Controls received mp w/ vehicle; animal info (10–11 weeks old Il18r1-KO, WT mice); brain infusion kit used; behavioral testing (cold-challenge); brain tissue distribution; effects of interleukin-18 on food intake, body composition and iWAT morphology; Dose (20Ǩg/mouse/7 days,);.

12347 Jung, H.K., Ryu, H.J., Kim, M.J., Kim, W.I., Choi, H.K., Choi, H.C., Song, H.K., Jo, S.M., Kang, T.C. Interleukin-18 attenuates disruption of brain-blood barrier induced by status epilepticus within the rat piriform cortex in interferon-gamma independent pathway. Brain Research 2012; 1447(-;-):126-134. >>> Interleukin-18; antibody, anti-rat, IFN gamma; Saline; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 7 wks old); ALZET brain infusion kit 1 used.

10508 Yaguchi, T., Nagata, T., Yang, D.Q., Nishizaki, T. Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity. Behavioural Brain Research 2010; 206(-1-):47-51. >>> Interleukin-18; CSF/CNS; Mice; 1007D; Controls received mp w/ serum; animal info (wt, IL-18 KO); behavioral testing (water maze test).

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25. Interleukin-31

16334 Feld, M., Garcia, R., Buddenkotte, J., Katayama, S., Lewis, K., Muirhead, G., Hevezi, P., Plesser, K., Schrumpf, H., Krjutskov, K., Sergeeva, O., Muller, H. W., Tsoka, S., Kere, J., Dillon, S. R., Steinhoff, M., Homey, B. The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves. J Allergy Clin Immunol 2016; 138(-2-):500-508 e24. >>> Interleukin-31, recombinant mouse; SC; Mice; animal info (6– 8 week old, C57BL/6 and Trpv1 knockout mice); functionality of mp verified by observation of skin phenotype; dose-response (pg. 508.e5); Dose (20 mg/day);.

7218 Dillon, S.R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S.R., Haugen, H.S., Maurer, M., Harder, B., Johnston, J., Bort, S., Mudri, S., Kuijper, J.L., Bukowski, T., Shea, P., Dong, D.L., Dasovich, M., Grant, F.J., Lockwood, L., Levin, S.D., LeCiel, C., Waggie, K., Day, H., Topouzis, S., Kramer, J., Kuestner, R., Chen, Z., Foster, D., Parrish-Novak, J., Gross, J.A. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. NATURE IMMUNOLOGY 2004; 5(-7-):752-760. >>> Interleukin-31, mouse; PBS; BSA; SC; Mice; Controls received mp w/ vehicle; immunology.

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26. Leukemia Inhibitor Factor

16166 Rhee, Y. H., Yi, S. H., Kim, J. Y., Chang, M. Y., Jo, A. Y., Kim, J., Park, C. H., Cho, J. Y., Choi, Y. J., Sun, W., Lee, S. H. Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. Sci Rep 2016; 6(--):32025. >>> Raf-Transducer cells, conditioned media; leukemia inhibitory factor; fibroblast growth factor 2; vascular endothelial growth factor; CSF, artificial; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle or control media; animal info (male, C57Bl6, 50-100g); ALZET brain infusion kit 2 used; immunology; cyanoacrylate adhesive; Brain coordinates;.

13411 Liu, Y., Peng, M.Y., Zang, D.W., Zhang, B.S. Leukemia inhibitory factor promotes nestin-positive cells, and increases gp130 levels in the Parkinson disease mouse model of 6-hydroxydopamine. Neurosciences 2013; 18(-4-):363-370. >>> Leukemia inhibitory factor; Saline; CSF/CNS (intrathecal); Mice; 2002; Controls received mp w/ vehicle or sham surgery; animal info (C57BL, 8 weeks old); neurodegenerative (Parkinson's disease); no stress (see pg. 368); behavioral testing (rotarod, bar grabbing, tremor analysis);.

12697 Huang, W.H., Li, Y.D., Lin, Y.F., Ye, X., Zang, D.W. Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction. Neural Regeneration Research 2012; 7(-19-):1469-1474. >>> Leukemia inhibitory factor; fibroblast growth factor, basic; Saline, normal; Mice; Animal info (C57BL/6, male, 8 wks old).

3020 Barnard, W., Bower, J., Brown, M.A., Murphy, M., Austin, L. Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: injured muscle expresses lif mRNA. J. Neurol. Sci 1994; 123(--):108-113. >>> Leukemia inhibitory factor; PBS; Serum, mouse; Radio-isotopes; 125I tracer; IM (muscle crush); mice; 2001; controls received mp with serum and PBS; peptides; tissue perfusion (muscle crush); mouse serum lessened adsorption to pump reservoir; narrowed catheter sutured to adjacent muscles; iodinated LIF used to confirm targeted delivery.

2620 Moran, C.S., Campbell, J.H., Simmons, D.L., Campbell, G.R. Human leukemia inhibitory factor inhibits development of experimental atherosclerosis. Arterioscler. Thromb 1994; 14(-8-):1356-1363. >>> Leukemia inhibitory factor; PBS; IP; rabbit; 2ML4; controls received mp w/ saline; functionality of mp verified by checking residual termination volume; peptides.

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27. Leukemia Inhibitory Factor

Q3111 Liu,Y., Peng,M.Y., Zang,D.W., Zhang,B.S. Leukemia inhibitory factor promotes nestin-positive cells, and increases gp130 levels in the Parkinson disease mouse model of 6-hydroxydopamine. Neurosciences 2013; 18(-4-):363-370. >>> Leukemia inhibitory factor; Saline; CSF/CNS (intrathecal); Mice; 2002; 3 weeks; Controls received mp w/ vehicle or sham surgery; animal info (C57BL, 8 weeks old); neurodegenerative (Parkinson's disease); no stress (see pg. 368); behavioral testing (rotarod, bar grabbing, tremor analysis);.

Q2411 Huang,W.H., Li,Y.D., Lin,Y.F., Ye,X., Zang,D.W. Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction. Neural Regeneration Research 2012; 7(-19-):1469-1474. >>> Leukemia inhibitory factor; fibroblast growth factor, basic; Saline, normal; Mice; 21 days; Animal info (C57BL/6, male, 8 wks old).

P9324 Averill,S., Inglis,J.J., King,V.R., Thompson,S.W.N., Cafferty,W.B.J., Shortland,P.J., Hunt,S.P., Kidd,B.L., Priestley,J.V. Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis. Neuroscience 2008; 155(-4-):1227-1236. >>> Nerve growth factor, recomb. human; glial-derived neurotrophic factor, recomb. human; leukemia inhibitory factor, recomb. human; Saline; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides, animal info (male, Wistar, 220-400 g.).

P8689 White,C.A., Zhang,J.G., Salamonsen,L.A., Baca,M., Fairlie,W.D., Metcalf,D., Nicola,N.A., Robb,L., Dimitriadis,E. Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-49-):19357-19362. >>> Leukemia inhibitory factor, antagonist; PBS; IP; Mice; ; Functionality of mp verified by plasma levels taken; comparison of SC/IP injections vs. mp; animal info (8-10 wk old, female, C57BL/6J).

P8153 Bauer,S., Patterson,P.H. Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. Journal of Neuroscience 2006; 26(-46-):12089-12099. >>> Ara-C; leukemia inhibitory factor, recomb. mouse; epidermal growth factor, recomb. human; Saline; PBS; BSA; CSF/CNS; Mice; 1003D; 1007D; 1, 3, 6, 7, days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 or 3 used; peptides; animal info (adult, male, C57BL/6J, 2-6 months old).

P6100 Feeney,S.J., Austin,L., Bennett,T.M., Kurek,J.B., Jean-Francois,M.J.B., Muldoon,C., Byrne,E. The effect of leukaemia inhibitory factor on SOD1 G93A murine amyotrophic lateral sclerosis. Cytokine 2003; 23(-4-5-):108-118. >>> Leukemia inhibitory factor; CSF/CNS (intrathecal); Mice (transgenic); 2004; 13 weeks; Comparison of SC injections vs. IT mp; long-term study; pumps replaced every 4 weeks; ALZET brain infusion kit 1 used (per Dr. Feeney); used the BIK for the IT infusion; glued and sutured the cannula in place; "All mice that entered the study recovered from the surgical procedure and appeared to have no adverse effects." (p. 111); neurodegenerative (Amyotrophic Lateral Sclerosis).

P5692 Rolfe,B.E., Stamatiou,S., World,C.J., Brown,L., Thomas,A.C., Bingley,J.A., Worth,N.F., Campbell,J.H. Leukaemia inhibitory factor retards the progression of atherosclerosis. Cardiovascular Research 2003; 58(-1-):222-230. >>> Leukemia inhibitory factor; Saline; IP; Rabbit; 2ML4; 4 weeks; Controls received mp w/ vehicle; peptides; atherosclerosis.

P5632 Wahle,P., Di Cristo,G., Schwerdtfeger,G., Engelhardt,M., Berardi,N., Maffei,L. Differential effects of cortical neurotrophic factors on development of lateral geniculate nucleus and superior colliculus neurons: anterograde and retrograde actions. Development 2003; 130(-3-):611-622. >>> Nerve growth factor; NT-4/5; brainderived neurotrophic factor; leukemia inhibitory factor; CSF/CNS (visual cortex); Rat; 1007D; 7 days; Controls received mp w/ cytochrome C; peptides..

P4937 Cafferty,W.B.J., Gardiner,N.J., Gavazzi,I., Powell,J., McMahon,S.B., Heath,J.K., Munson,J., Cohen,J., Thompson,S.W.N. Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. Journal of Neuroscience 2001; 21(-18-):7161-7170. >>> Leukemia inhibitory factor; Saline; CSF/CNS (intrathecal, Dorsal Root Ganglia); rat; 2002; 2 weeks; controls received mp w/ vehicle; peptides; brain tissue distribution; recombinant human LIF used; some animals had undergone nerve injury axotomy on either the tibial or sciatic nerves, other remained uninjured.

P4574 Kurek,J.B, Bower,J.J, White,J.D., Muldoon,C.M, Austin,L. Leukaemia inhibitory factor and other cytokines as factors influencing regeneration of skeletal muscle.. Basic Appl.Myol 1998; 8(-5-):347-360. >>> Leukemia inhibitory factor; Interleukin-6; Transforming growth factor-a;; PBS;; IM;; mice;; 7 days;; controls received mp w/vehicle; tissue perfusion (vastus lateralis muscle); peptides; targeted delivery of growth factors to the site of muscle injury via a cannula; "drug delivery targeted to a discrete tissue or organ offers signicant advantages over systemic administration". (p. 355).

P4364 Leong,J., Hayes,A., Austin,L., Morrison,W. Muscle protection following motor nerve repair in combination with leukemia inhibitory factor. J.Hand Surg.[Am] 1999; 24A(--):37-45. >>> Leukemia inhibitory factor;; Serum, rat; Saline; Radio-isotopes; 125I tracer;; CSF/CNS (gastrocnemius nerve);; rat;; 2004;; 28 days;; controls received mp with vehicle; tissue perfusion (nerve repair site); functionality of mp verified by cross-section; peptides; recomb. mouse LIF used; rat serum reduced binding to pump reservoir; bioavailabilitiy of LIF was 50%; diagram of experimental model (p. 40).

P3974 Cheema,S.S., Arumugam,D., Murray,S.S., Bartlett,P.F. Leukemia inhibitory factor maintains choline acetyltransferase expression in vivo. NeuroReport 1998; 9(-3-):363-366. >>> Leukemia inhibitory factor; CSF/CNS; rat; 2002; 14 days; controls received mp w/PBS; peptides; ALZET brain infusion kit used.

P3810 Moran,C.S., Campbell,J.H., Campbell,G.R. Human leukemia inhibitory factor upregulates LDL receptors on liver cells and decreases serum cholesterol in the cholesterol-fed rabbit. Arterioscler.Thromb.Vasc.Biol. 1997; 17(--):1267-1273. >>> Leukemia inhibitory factor; PBS; IP; rabbit; 2ML4; 4 weeks; controls received mp w/vehicle; functionality of mp verified by plasma levels and residual volume; peptides; recomb. human leukemia inhibitory factor used; wrong pump model number described in methods section as 4ML2; graph of pump functionality shown on page 1270; "The present study showed that the osmotic minipumps delivered the prescribed volume throughout the entire 4-week treatment." (p. 1271).

P3644 Akita,S., Malkin,J., Melmed,S. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology 1996; 137(-7-):3140-3143. >>> Leukemia inhibitory factor; SC; mice; 1007D; 5 days; controls received PBS infusion; peptides; mice had disrupted LIF gene; recomb. human LIF used.

P3592 Kurek,J., Bower,J., Romanella,M., Austin,L. Leukemia inhibitory factor treatment stimulates muscle regeneration in the mdx mouse. Neuroscience Letters 1996; 212(--):167-170. >>> Leukemia inhibitory factor; Saline; Serum, mouse; IM; mice; 2001; 7 days; controls received mp w/ vehicle; tissue perfusion (muscle); peptides; recomb. murine LIF used.

P3557 Tang,W.W., Qi,M., Van,G.Y., Wariner,G.P., Samal,B. Leukemia inhibitory factor ameliorates experimental anti-GBM Ab glomerulonephritis. Kidney Int. 1996; 50(--):1922-1927. >>> Leukemia inhibitory factor; Saline; IP; rat; 1003D; 24 hours; controls received mp w/ saline; peptides; "Continuous infusion of rhLIF was chosen due to the short half-life of this peptide" (p.1926); recomb. human LIF used.

P2918 Barnard,W., Bower,J., Brown,M.A., Murphy,M., Austin,L. Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: injured muscle expresses lif mRNA. J.Neurol.Sci. 1994; 123(--):108-113. >>> Leukemia inhibitory factor; PBS; Serum, mouse; Radio-isotopes; 125I tracer; IM (muscle crush); mice; 2001; 7 days; 24 hours; controls received mp with serum and PBS; peptides; tissue perfusion (muscle crush); mouse serum lessened adsorption to pump reservoir; narrowed catheter sutured to adjacent muscles; iodinated LIF used to confirm targeted delivery.

P2532 Moran,C.S., Campbell,J.H., Simmons,D.L., Campbell,G.R. Human leukemia inhibitory factor inhibits development of experimental atherosclerosis. Arterioscler.Thromb. 1994; 14(-8-):1356-1363. >>> Leukemia inhibitory factor; PBS; IP; rabbit; 2ML4; 28 days; controls received mp w/ saline; functionality of mp verified by checking residual termination volume; peptides.

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28. Tumor Necrosis Factor

Q4388 Cunningham,MW Jr, West,C.A., Wen,X.R., Deng,A.H., Baylis,C., Cunningham,MW Jr. Pregnant rats treated with a high-fat/prooxidant Western diet with ANG II and TNF-alpha are resistant to elevations in blood pressure and renal oxidative stress. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2015; 308(--):R945-R956. >>> Angiotensin II; tumor necrosis factor, alpha; SC; Rat (pregnant); 2ML2; 14 days; Controls received mp w/ saline; animal info (female, Sprague Dawley, 15-21 weeks, day 6 of pregnancy); cardiovascular; peptides;.

Q4038 Pajer,K., Feichtinger,G.A., Marton,G., Sabitzer,S., Klein,D., Redl,H., Nogradi,A., Nogradi,A. Cytokine signaling by grafted neuroectodermal stem cells rescues motoneurons destined to die. Experimental Neurology 2014; 261(--):180-189. >>> Antibody, anti-interleukin-1a; antibody, anti-interleukin-6; antibody, tumor necrosis factor-alpha; antibody, macrophage inflammatory protein-1 alpha; CSF/CNS (intrathecal); Rat; 1002; 2 weeks; Controls received mp w/ control antibody; animal info (female, Sprague Dawley, adult); functionality of mp verified by decreased activity of targets; used silicone tubing 0.3 mm ID for catheter; catheter was fixed to surrounding muscle with 8-0 sutures; pumps removed after 2 weeks;.

Q3776 Matsuda,T., Murao,N., Katano,Y., Juliandi,B., Kohyama,J., Akira,S., Kawai,T., Nakashima,K., Nakashima,K. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nature Communications 2015; 6(--):U26-U35. >>> Tumor necrosis factor receptor 1; CSF/CNS (cortex); Mice; 1002; 5 days; Control animals received mp w/ vehicle; animal info (C57BL/6, male).

Q3560 Martel,C.A., Mamedova,L.K., Minton,J.E., Jones,M.L., Carroll,J.A., Bradford,B.J., Bradford,B.J. Continuous low-dose infusion of tumor necrosis factor alpha in adipose tissue elevates adipose tissue interleukin 10 abundance and fails to alter metabolism in lactating dairy cows. Journal of Dairy Science 2014; 97(--):4897-4906. >>> Tumor necrosis factor alpha; Saline; SC; Cattle (lactating); 2ML1; 7 days; Controls received mp w/ vehicle; animal info (female, Holstein, late lactation); Multiple pumps per animal (2); immunology;.

Q2898 Bobek,G., Stait-Gardner,T., Surmon,L., Makris,A., Lind,J.M., Price,W.S., Hennessy,A. Magnetic Resonance Imaging Detects Placental Hypoxia and Acidosis in Mouse Models of Perturbed Pregnancies. PLoS One 2013; 8(-3-):U1167-U1172. >>> Tumor necrosis factor, alpha; SC; Mice; 1007D; ; Controls received mp w/ saline; animal info (C57BL/6JArc, pregnant, gestation day 13.5); mp used to infuse TNF-a to induce hypertension in pregnant mice.

Q2718 Worlitzer,M.M.A., Bunk,E.C., Hemmer,K., Schwamborn,J.C. Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice. STEM CELL RESEARCH&THERAPY 2012; 3(-;-):U1-U12. >>> Tumor necrosis factor, alpha; Saline; CSF/CNS; Mice; 1002; 14 days; Control animals received mp w/ vehicle; animal info (C57BL/6, 20 g); ALZET brain infusion kit 3 used.

Q2665 Chu,J.J., Zhang,H.X., Huang,X.Q., Lin,Y.J., Shen,T., Chen,B.D., Man,Y., Wang,S., Li,J. Apelin Ameliorates TNF-alpha-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ. PLoS One 2013; 8(-2-):U968-U975. >>> Tumor necrosis factor, alpha; NaCl; BSA; SC; Mice; 7 days; Animal info (C57BL/6J, male, 12 wks old); 1.0 ul/hr rate of infusion.

Q2333 Yi,W., Sun,Y., Yuan,Y.X., Lau,W.B., Zheng,Q.J., Wang,X.L., Wang,Y.J., Shang,X.Y., Gao,E.H., Koch,W.J., Ma,X.L. C1q/Tumor Necrosis Factor-Related Protein-3, a Newly Identified Adipokine, Is a Novel Antiapoptotic, Proangiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart. Circulation 2012; 125(-25-):3159-+. >>> Tumor necrosis factor related protein 3, C1q, recomb.; IP; Mice; 2 weeks; Control animals received mp w/ vehicle; animal info (C57BL/6, male, adult); functionality of mp verified via plasma drug levels.

Q1874 Hambly,C., Duncan,J.S., Archer,Z.A., Moar,K.M., Mercer,J.G., Speakman,J.R. Repletion of TNF-alpha or leptin in calorically restricted mice suppresses post-restriction hyperphagia. Disease Models&Mechanisms 2012; 5(-1-):83-94. >>> Leptin; tumor necrosis factor, alpha, recomb. murine; Mice; 2002; ; Controls received mp w/ PBS; animal info (male, MF1).

Q1517 Sunderland,N.S., Thomson,S.E., Heffernan,S.J., Lim,S., Thompson,J., Ogle,R., McKenzie,P., Kirwan,P.J., Makris,A., Hennessy,A. Tumor necrosis factor alpha induces a model of preeclampsia in pregnant baboons (Papio hamadryas). Cytokine 2011; 56(-2-):192-199. >>> Tumor necrosis factor-alpha; PBS; IV (femoral); Monkey (pregnant, baboon); 2ML4; ; Controls received mp w/ vehicle; animal info (female, baboon, Papio hamadryas).

Q1471 Ryu,H.J., Kim,J.E., Yeo,S.I., Kang,T.C. p65/RelA-Ser529 NF-kappa-B Subunit Phosphorylation Induces Autophagic Astroglial Death (Clasmatodendrosis) Following Status Epilepticus. Cellular and Molecular Neurobiology 2011; 31(-7-):1071-1078. >>> Tumor necrosis factor, alpha, p55 receptor; Saline; CSF/CNS; Rat; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (Sprague-Dawley); ALZET brain infusion kit 1 used.

Q1381 Wahl,E.C., Aronson,J., Liu,L.C., Skinner,R.A., Miller,M.J., Cockrell,G.E., Fowlkes,J.L., Thrailkill,K.M., Bunn,R.C., Ronis,M.J.J., Lumpkin,CK Jr. Direct bone formation during distraction osteogenesis does not require TNF alpha receptors and elevated serum TNF alpha fails to inhibit bone formation in TNFR1 deficient mice. Bone 2010; 46(-2-):410-417. >>> Tumor necrosis factor-alpha, recomb. murine; PBS; BSA; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6, R1KO, R2KO).

Q0768 Bobadilla,R.A., van Bree,R., Vercruysse,L., Pijnenborga,R., Verhaeghe,J. Placental Effects of Systemic Tumour Necrosis Factor-alpha in an Animal Model of Gestational Diabetes Mellitus. PLACENTA 2010; 31(-12-):1057-1063. >>> Tumor necrosis factor, recomb. mouse; SC; Mice; 2001; 7 days; Controls received mp w/ saline; animal info (db/+, gd11.5).

Q0520 Tian,Q., Miyazaki,R., Ichiki,T., Imayama,I., Inanaga,K., Ohtsubo,H., Yano,K., Takeda,K., Sunagawa,K. Inhibition of Tumor Necrosis Factor-alpha-Induced Interleukin-6 Expression by Telmisartan Through Cross-Talk of Peroxisome Proliferator-Activated Receptor-gamma With Nuclear Factor kappa B and CCAAT/Enhancer- Binding Protein-beta. Hypertension 2009; 53(-5-):798-804. >>> Angiotensin II; tumor necrosis factor-alpha; DMEM; water, sterile; SC; Mice; 1 week; Animal info (9 wks old, C57/BL6); peptides.

Q0192 Wahl,E.C., Aronson,J., Liu,L.C., Fowlkes,J.L., Thrailkill,K.M., Bunn,R.C., Skinner,R.A., Miller,M.J., Cockrell,G.E., Clark,L.M., Ou,Y., Isales,C.M., Badger,T.M., Ronis,M.J., Sims,J., Lumpkin,CK Jr. Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF. Journal of Bone and Mineral Research 2010; 25(-1-):114-123. >>> Tumor necrosis factor, recomb. mouse; PBS; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6 wt, p21 KO, 3 months old, distraction osteogenesis); functionality of mp verified by TNF serum levels.

P9937 Cavadini,G., Petrzilka,S., Kohler,P., Jud,C., Tobler,I., Birchler,T., Fontana,A. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-31-):12843-12848. >>> Tumor necrosis factor-alpha; BSA; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (7 wks old, C57BL/6).

P9916 Takaoka,M., Suzuki,H., Shioda,S., Sekikawa,K., Saito,Y., Nagai,R., Sata,M. Endovascular Injury Induces Rapid Phenotypic Changes in Perivascular Adipose Tissue. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010; 30(-8-):1576-1582. >>> Tumor necrosis factor-alpha, recomb; Periadventitial; Mice; 4 weeks; Controls received mp w/ PBS.

P9760 Keithley,E.M., Wang,X.B., Barkdull,G.C. Tumor necrosis factor alpha can induce recruitment of inflammatory cells to the cochlea. OTOLOGY&NEUROTOLOGY 2008; 29(-6-):854-859. >>> Tumor necrosis factor-alpha; Ear (cochlea); Guinea-pig; 2001; 2-4 days; Controls received mp w/vehicle; animal info (Hartley albino); tissue perfusion.

P9512 Hinojosa,E., Boyd,A.R., Orihuela,C.J. Age-Associated Inflammation and Toll-Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia. Journal of Infectious Diseases 2009; 200(-5-):546-554. >>> Tumor necrosis factor-a; PBS; albumin, mouse serum; SC; Mice; 1007D; 5, 6 days; Controls received mp w/ vehicle; animal info (young Balb/cby, adult); immunology.

P9437 Riazi,K., Galic,M.A., Kuzmiski,J.B., Ho,W., Sharkey,K.A., Pittman,Q.J. Microglial activation and TNF alpha production mediate altered CNS excitability following peripheral inflammation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-44-):17151-17156. >>> Tumor necrosis factor-a; Saline; albumin, rat; chlorbutanol; CSF/CNS; Rat; 1007D; 4 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague Dawley, 175-200 g.).

P9407 Giachini,F.R.C., Zemse,S.M., Carneiro,F.S., Lima,V.V., Carneiro,Z.N., Callera,G.E., Ergul,A., Webb,R.C., Tostes,R.C. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-2-):H489-H496. >>> Tumor necrosis factor-a; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by serum TNFa levels; cardiovascular; animal info (male, C57BL/6, wt, IL-1D -/-, 10 wks old).

P9211 LaMarca,B., Wallukat,G., Llinas,M., Herse,F., Dechend,R., Granger,J.P. Autoantibodies to the Angiotensin Type I Receptor in Response to Placental Ischemia and Tumor Necrosis Factor-alpha in Pregnant Rats. Hypertension 2008; 52(-6-):1168-1172. >>> Tumor necrosis factor-a; Rat (pregnant); 2002; 5 days; Functionality of mp verified by serum TNFa levels; cardiovascular; peptides; ischemia (placental); animal info (female, Sprague Dawley, gd 14-19).

P9164 Sud,R., Spengler,R.N., Nader,N.D., Ignatowski,T.A. Antinociception occurs with a reversal in alpha2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory. European Journal of Pharmacology 2008; 588(-2-3-):217-231. >>> Tumor necrosis factor, recomb. rat; CSF, artificial; CSF/CNS; Rat; 2002; ; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, Sprague Dawley, 200-300 g.); gentamycin was added to the aCSF to prevent bacterial growth; rat albumin was added to stabilize the infused compound.

P9099 Grabbe,S., Gallo,R.L., Lindgren,A., Granstein,R.D. Deficient antigen presentation by Langerhans cells from athymic (nu/nu) mice. Restoration with thymic transplantation or administration of cytokines. J.Immunol. 1993/10/1; 151(-7-):3430-3439. >>> Colony-stimulating factor, GM, murine; tumor necrosis factor-a, recomb. mouse; interleukin-1a, recomb. human; PBS; IP; Mice (nude); 2002; 10 days; Controls received mp w/ normal saline; immunology; peptides; animal info (BALB/c, athymic, nu/nu, euthymic, 2-4 wks old).

P9000 Steinberg,G.R., Michell,B.J., van Denderen,B.J.W., Watt,M.J., Carey,A.L., Fam,B.C., Andrikopoulos,S., Proietto,J., Goerguen,C.Z., Carling,D., Hotamisligil,G.S., Febbraio,M.A., Kay,T.W., Kemp,B.E. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism 2006; 4(-6-):465-474. >>> Tumor necrosis factor-a; Saline; Mice; 1003D; 24 hours; Controls received mp w/ vehicle; no stress (see pg. 468); animal info (C57BL/6, wt, TNFR1 -/-).

P8942 Lambin,S., van Bree,R., Vergote,I., Verhaeghe,J. Chronic tumor necrosis factor-alpha infusion in gravid C57BL6/J mice accelerates adipose tissue development in female offspring. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 2006; 13(-8-):558-565. >>> Tumor necrosis factor-alpha, recomb. mouse; SC; Mice (pregnant); 2001; 7 days; Controls received mp w/ saline; dose-response (fig. 1); no stress (see pg. 560); teratology; peptides; animal info (female, C57BL/6, gd 11.5-18.5); endocrinology.

P8521 LaMarca,B.D., Chandler,D.L., Grubbs,L., Bain,J., McLernore,GR Jr, Granger,J.P., Ryan,M.J. Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure. American Journal of Hypertension 2007; 20(-11-):1216-1221. >>> Tumor necrosis factor; Saline; heparin; IV; Rat; 2001; 5 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); cardiovascular; animal info (female, Sprague-Dawley, 15 weeks old).

P8369 Peterson,J.M., Feeback,K.D., Baas,J.H., Pizza,F.X. Tumor necrosis factor-alpha promotes the accumulation of neutrophils and macrophages in skeletal muscle. Journal of Applied Physiology 2006; 101(-5-):1394-1399. >>> Tumor necrosis factor-a, recomb. mouse; Saline, physiological; albumin, mouse serum; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; no stress (see pg. 1396); peptides; animal info (male, C57BL/6J, 27-30g.).

P8246 Sud,R., Ignatowski,T.A., Lo,C.P.K., Spengler,R.N. Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain. BRAIN BEHAVIOR AND IMMUNITY 2007; 21(-1-):112-124. >>> Tumor necrosis Factor-a, recomb. rat: tumor necrosis factor-a, recomb. rat, heat-inactivated; amitriptyline; CSF, artificial; CSF/CNS; Rat; 8 days; Controls received mp w/ vehicle, or heat-inactivated rr-TNFa; comparison of ip injections vs. mp; peptides; animal info (male, Sprague-Dawley, 300-350g); chronic constriction injury to the right sciatic nerve; neuropathic pain.

P8058 Wahl,E.C., Perrien,D.S., Aronson,J., Liu,Z.D., Fletcher,T.W., Skinner,R.A., Feige,U., Suva,L.J., Badger,T.M., Lumpkin,CK Jr. Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: A role for the tumor necrosis factor signaling axis. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 2005; 29(-8-):1466-1472. >>> Interleukin-1 receptor antagonist; tumor necrosis factor-a, recomb. rat; interleukin-1, recomb. rat; PBS; BSA; SC; bone (tibia); Rat; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig 3); no stress (see p. 1467, 1468, 1469); peptides; tissue perfusion (tibia); post op. care (buprenex); animal info (male, Sprague-Dawley).

P7788 Suzuki,Y., Aoki,K., Saito,H., Umeda,M., Nitta,H., Baron,R., Ohya,K. A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice. Journal of Periodontal Research 2006; 41(-2-):81-91. >>> Tumor necrosis factor receptor peptide WP9QY; PBS; DMSO; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig. 4); no stress (see pg. 85, 89-90); peptides; animal info (Balb/c, male, 4 wk. old); 10% DMSO; "the WP9QY peptide degrades very fast, which is the reason why we use osmotic mini pump in this study" (pg. 90).

P7787 Aoki,K., Saito,H., Itzstein,C., Ishiguro,M., Shibata,T., Blanque,R., Mian,A.H., Takahashi,M., Suzuki,Y., Yoshimatsu,M., Yamaguchi,A., Deprez,P., Mollat,P., Murali,R., Ohya,K., Horne,W.C., Baron,R. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. Journal of Clinical Investigation 2006; 116(-6-):1525-1534. >>> Tumor necrosis factor receptor peptide WP9QY; peptides, synthetic; PBS; DMSO; SC; Mice; 2002; 4 weeks; 3 days; Controls received mp w/ vehicle, or control peptide; dose-response (pg. 1530); pumps replaced after 2 weeks; no stress ( see pg. 1529); peptides; animal info (female, C57BL/6J, 12 wk old); 10% DMSO; inhibits osteoclastogenesis and bone resorption.

P7251 LaMarca,B.B.D., Cockrell,K., Sullivan,E., Bennett,W., Granger,J.P. Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension 2005; 46(-1-):82-86. >>> Tumor necrosis factor-a; Saline; Rat (pregnant); 2002; 5 days; Controls received mp w/ vehicle; functionality of mp verified by serum TNF-a levels; cardiovascular.

P7145 Mitchell,B.F., Zielnik,B., Wong,S., Roberts,C.D., Mitchell,J.M. Intraperitoneal infusion of proinflammatory cytokines does not cause activation of the rat uterus during late gestation. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2005; 289(-4-):E658-E664. >>> Interleukin-1 beta; tumor necrosis factor-alpha; Saline; IP; Rat (pregnant); 2001D; ; Controls received mp w/ vehicle; functionality of mp verified by residual volume.

P6991 Woiciechowsky,C., Schoening,B., Stoltenburg-Didinger,G., Stockhammer,F., Volk,H.D. Brain-IL-1beta triggers astrogliosis through induction of IL-6: Inhibition by propranolol and IL-10. MEDICAL SCIENCE MONITOR 2004; 10(-9-):BR325-BR330. >>> Tumor necrosis factor-a, recomb. rat; interleukin-1 beta, recomb. rat; interleukin-10, recomb. rat; interleukin-6, recomb. rat; Albumin, human serum; CSF/CNS; Rat; 1003D; 48 hours; Controls received mp w/ vehicle; dose-response (fig 1); ALZET brain infusion kit used; correct localization of cannula confirmed histologically.

P6776 Reynolds,J.L., Ignatowski,T.A., Sud,R., Spengler,R.N. Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant. Journal of Pharmacology and Experimental Therapeutics 2004; 310(-3-):1216-1225. >>> Tumor necrosis factor, recomb. rat; tumor necrosis factor, recomb. rat inactivated; serum, rabbit; antibody, polyclonal rabbit anti-mouse TNF; CSF, artificial; albumin, rat; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or heat-inactivated rr TNF; no stress (see pg. 1217-18); ALZET Brain Infusion Kit used.

P6653 Gaspersic,R., Stiblar-Martincic,D., Osredkar,J., Skaleric,U. In vivo administration of recombinant TNF-alpha promotes bone resorption in mice. Journal of Periodontal Research 2003; 38(-4-):446-448. >>> Tumor necrosis factor-alpha, recomb. mouse; PBS, pyrogen-free; PBS, sterile; SC; bone (parietal); Mice; 3 days; Controls received mp w/ vehicle.

P6437 Wenk,G.L., gann-Gramling,K., Hauss-Wegrzyniak,B. The presence of the APPswe mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation. Neuroscience 2004; 125(-3-):769-776. >>> Tumor necrosis factor-alpha; memantine; CSF, artificial; saline; CSF/CNS (basal forebrain); Mice (transgenic); 1002; 20 days; Controls received mp w/ vehicle; tissue perfusion (basal forebrain); multiple pumps per animal (2); Plastics One cannula used with tygon tubing; secured with dental cement; second pump contained memantine/saline and was implanted on the other side of the spine.

P6327 Bozkurt,B., Kribbs,S.B., Clubb,F.J., Michael,L.H., Didenko,V.V., Hornsby,P.J., Seta,Y., Oral,H., Spinale,F.G., Mann,D.L. Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-alpha Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats. Circulation 1998; 97(--):1382-1391. >>> Tumor Necrosis factor-; Albumin, rat serum; IP; Rat; 2002; 15 days; Controls received mp w/ vehicle; functionality of mp verified by tail blood samples; no stress (see pg. 1387); stability verified by tail blood samples; cardiovascular; peptides; TNF-a was recombinant human.

P6205 Guo,H.L., Epperly,M.W., Bernarding,M., Nie,S.H., Gretton,J., Jefferson,M., Greenberger,J.S. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis Lung Carcinomas. In Vivo 2003; 17(-1-):13-21. >>> Tumor necrosis factor-alpha; transforming growth factor-beta; interleukin-1; Saline, normal; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; no stress (see pg. 17); cancer (lung).

P6080 Wenk,G.L., McGann,K., Hauss-Wegrzyniak,B., Rosi,S. The toxicity of tumor necrosis factor-alpha; upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: Implications for Alzheimer's disease. Neuroscience 2003; 121(-3-):719-729. >>> Tumor necrosis factor-alpha; CSF, artificial; CSF/CNS (basal forebrain); Mice; 1002; 14 days; Controls received mp w/ vehicle; tissue perfusion (basal forebrain); Plastics One cannula used; "A volume overload to the brain tissue is minimal using this procedure because the 0.25 ul/hr administered contributes only about 0.2% of the total CSF volume produced by the mouse each hour..." p. 720; post op. care (1.0 ml of sterile saline (S.C) injected to prevent dehydration); neurodegenerative (Alzheimer's disease).

P5906 Nadeau,S., Rivest,S. Glucocorticoids play a fundamental role in protecting the brain during innate immune response. Journal of Neuroscience 2003; 23(-13-):5536-5544. >>> Tumor necrosis factor-alpha; L-NAME; endotoxin, LPS; Saline; BSA; ascorbic acid; PIPES; DMSO; CSF/CNS (cortex, dorsal basal ganglia); Rat; 2004; 3,7,14,21 days; Controls received mp w/ vehicle; tissue perfusion (cerebral tissue&dorsal ganglia); enzyme inhibitor (nitric oxide); brain tissue distribution; guid cannula used; TNF-a was dissolved in saline + 0.1% BSA + 0.01% ascorbic acid; L-NAME was dissolved in PIPES&10% DMSO&infused into the dorsal basal ganglia.

P5878 Schoning,B., Elepfandt,P., Daberkow,N., Rupprecht,S., Stockhammer,F., Stoltenburg,G., Volk,H.D., Woiciechowsky,C. Differences in immune cell invasion into the cerebrospinal fluid and brain parenchyma during cerebral infusion of interleukin-1 beta. NEUROLOGICAL SCIENCES 2002; 23(-5-):211-218. >>> Interleukin-1, beta; Interleukin-6; Tumor necrosis factor-a; Albumin, human serum; CSF/CNS (hypothalamus, lateral ventricle); Rat; 1003D; 4,8,24,48 hours; Controls received mp w/ vehicle; functionality of mp verified by CSF cell infiltration; dose-response (p. 213); ALZET brain infusion kit used; IL-1ßwas rat recomb; cannula position verified histologically; cytokine levels in CSF were assayed.

P5803 Korekane,H., Nishikawa,A., Imamura,K. Mechanisms mediating metabolic abnormalities in the livers of Ehrlich ascites tumor-bearing mice. Archives of Biochemistry and Biophysics 2003; 412(-2-):216-222. >>> Ornithine decarboxylase-inducing factor; Interleukin-1, alpha; tumor necrosis factor-µ; Interleukin-6; SC; IP; Mice; 1007D; 6 days; Controls received mp w/ PBS vehicle; cancer; IL-1µ(human recomb)&ornithine decarboxylase-inducing factor (ODC factor) were infused via IP route; IL-6 was infused (SC).

P5774 Torrente,Y., El Fahime,E., Caron,N.J., Del Bo,R., Belicchi,M., Pisati,F., Tremblay,J.P., Bresolin,N. Tumor necrosis factor-alpha (TNF-alpha) stimulates chemotactic response in mouse myogenic cells. CELL TRANSPLANTATION 2003; 12(-1-):91-100. >>> Tumor necrosis factor-a; Saline; IM; Mice; 2002; 5 days; Controls received mp w/ vehicle; tissue perfusion (tibialis anterior muscle); dose-response (p.95 fig M); perforated PE tubing used.

P5737 Gaspersic,R., Stiblar-Martincic,D., Osredkar,J., Skaleric,U. Influence of subcutaneous administration of recombinant TNF-alpha on ligature-induced periodontitis in rats. Journal of Periodontal Research 2003; 38(-2-):198-203. >>> Tumor necrosis factor-a; PBS; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; no stress "the pumps were tolerated well by the animals" (see pg. 199).

P5400 Ruan,H., Miles,P.D.G., Ladd,C.M., Ross,K., Golub,T.R., Olefsky,J.M., Lodish,H.F. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha-Implications for insulin resistance. Diabetes 2002; 51(-11-):3176-3188. >>> Tumor necrosis factor-a; PBS; BSA; IV (mesenteric); Rat; 2001D; 2ML1; 4 days; 24 hours; Controls received mp w/ vehicle; peptides; 1% BSA used.

P5217 Alexander,B.T., Cockrell,K.L., Massey,M.B., Bennett,W.A., Granger,J.P. Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression. Am.J Hypertens 2002; 15(-2 Pt 1-):170-175. >>> Tumor necrosis factor-a; Saline; IV (jugular); Rat (pregnant); 2002; 5 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; peptides; recomb. rat TNF-a used; hypertension.

P5199 Homma,Y., Brull,S.J., Zhang,J.M. A comparison of chronic pain behavior following local application of tumor necrosis factor alpha to the normal and mechanically compressed lumbar ganglia in the rat. Pain 2002/2; 95(-3-):239-246. >>> Tumor necrosis factor-a; Tumor Necrosis Factor-a, soluble receptor; HEPES, buffered saline; CSF/CNS (spinal cord, intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; silicon tubing used to perfuse L5 region dorsal root ganglion; good graphics (p.240); recomb. soluble TNF-a receptor.

P5196 El Haj,T., Poole,S., Farthing,M.J., Ballinger,A.B. Anorexia in a rat model of colitis: interaction of interleukin-1 and hypothalamic serotonin. Brain Res 2002/2/8; 927(-1-):1-7. >>> Antibody, anti-Tumor necrosis factor-a; Interleukin-1 receptor antagonist; Immunoglobulin G; Saline; CSF/CNS (paraventricular nucleus); CSF/CNS; Rat; 1007D; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by checking residual volume; peptides; multiple pumps per animal (2); 1007D delivered IL-1 receptor antagonist or saline to paraventricular nucleus; 2001 pumps delivered anti-TNF-a antibody to PVN; bilateral cannulae used; bilateral infusion;.

P5094 Matsuno,H., Yudoh,K., Katayama,R., Nakazawa,F., Uzuki,M., Sawai,T., Yonezawa,T., Saeki,Y., Panayi,G.S., Pitzalis,C., Kimura,T. The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. Rheumatology 2002; 41(--):329-337. >>> Tumor necrosis factor-a; Interleukin-6; Serum, fetal bovine; Culture medium, RPMI 1640; SC; Mice (SCID); 1007D; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum cytokine levels; immunology; peptides; cytokines were recombinant; pump incorrectly called an osmium pump (p. 331); agents administered singly..

P4675 Jander,S, Schroetter,M, Fischer,J, Stoll,G. Differential regulation of microglial keratan sulfate immunoreactivity by proinflammatory cytokines and colony-stimulating factors.. Glia 2000; 30(--):401-410. >>> Interferon-gamma; Tumor necrosis factor-a;; PBS, sterile;; CSF/CNS;; rat;; 1007D;; 6 days;; Controls received mp w/ vehicle; immunology; peptides; ALZET brain infusion kit used; proinflammatory cytokines;.

P4672 Nickola,T.J., Ignatowski,T.A., Spengler,R.N. Antidepressant drug administration modifies the interactive relationship between a2-adrenergic sensitivity and levels of TNF in the rat brain.. Journal of Neuroimmunology 2000; 107(--):50-58. >>> Tumor necrosis factor-a; CSF, artificial;; CSF/CNS;; rat;; 14 days;; Stability verified by WEHI-13 VAR fibroblast cylotoxicity assay; peptides; ALZET brain infusion kit used; recomb. rat TNF used;.

P4618 Postma,N.S, Hermsen,C.C., Crommelin,D.J.A, Zuidema,J, Eling,W.M.C. Treatment with recombinant human tumour necrosis factor-a reduces parasitaemia and prevents Plasmodium berghei K173- induced experimental cerebral malaria in mice.. Parasitology 1999; 118(--):7-15. >>> Tumor necrosis factor-a; Saline;; IP;; mice;; 2001;; 7 days;; controls received mp w/vehicle; functionlaity of mp verified by increased concentration of soluble mouse TNF receptor R 75; comparison of SC injections of free or liposome-encapsulated TNF vs. mp; half-life is less than 20 minutes (p. 12); immunology; peptides; 10 fold lower dose was needed when TNF-alpha was infused rather than injected..

P4463 Lee,H.-M, Takeyama,K, Dabbagh,K, Lausier,J.A, Ueki,I.F, Nadel,J.A. Agarose plug instillation causes goblet cell metaplasia by activating EGF receptors in rat airways.. Am.J.Physiol.(Lung Cell.Mol.Physiol.) 2000; 278(--):L185-L192. >>> Antibody, anti-tumor necrosis factor-a;; Saline;; SC;; rat;; 2ML1;; ; peptides;.

P4390 Ignatowski,T.A., Covey,W.C., Knight,P.R., Severin,C.M., Nickola,T.J., Spengler,R.N. Brain-derived TNFa mediates neuropathic pain. Brain Research 1999; 841(--):70-77. >>> Antibody, monoclonal hamster anti-murine TNFalpha; Antibody, polyclonal rabbit anti-mouse TNFa; Tumor necrosis factor-a;; CSF, artificial; Gentamycin; Albumin, rat;; CSF/CNS;; rat;; 2002;; 14 days;; controls received mp with aCSF, normal rabbit serum or Armenian hamster IgG isotype control antibody; stability of each antibody, control, and rrTNFa verified by bioassay following 14 days of incubation in aCSF at 37ºC; peptides; ALZET brain infusion kit used; pain;.

P4097 Plata-Salaman,C.R., Sonti,G., Borkoski,J.P., Wilson,C.D., ffrench-Mullen,J.M.H. Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol.Behav. 1996; 60(-3-):867-875. >>> Interleukin-1 receptor antagonist; Interleukin-6; Interleukin-1, beta heat inactivated; Interleukin-8; Interleukin-1, beta; Tumor necrosis factor-a; Saline, sterile physiological; BSA; CSF/CNS; rat; 2001; 7 days; controls received mp w/vehicle; guide cannula was used, and a sterile 29 g stainless steel obturator was used to ensure cannula patency during at least a 10 day recovery period after surgery; BSA added as stabilizing agent and carrier protein for cytokines; recomb. human IL-6&8 used.

P3893 Van der Meer,M.J.M., Sweep,C.G.J.F., Pesman,G.J., Borm,G.F., Hermus,R.M.M. Synergism between IL-1B and TNF-a on the activity of the pituitary-adrenal axis and on food intake of rats. Am.J.Physiol.(Endocrinol.Metab.) 1995; 268(-31-):E551-E557. >>> Tumor necrosis factor-a; Interleukin-1, beta; Saline, sterile; PBS; NaCl; IP; rat; 1003D; 3 days; controls received mp w/saline; dose-response; no stress (see pg. E552); immunology; peptides; animals received drugs singly or in combination; recomb. human TNF&IL-1 used.

P2938 Stevens,T., Morris,K., McMurtry,I.F., Zamora,M., Tucker,A. Pulmonary and systemic vascular responsiveness to TNF-a in conscious rats. J.Appl.Physiol. 1993; 74(-4-):1905-1910. >>> Tumor necrosis factor-a; Saline, sterile isotonic; IP; rat; 2002; 2 weeks; controls received mp with saline; peptides; recomb. human TNF used.

P2497 Pang,X-P., Hershman,J.M., Pekary,A.E. Plasma disappearance and organ distribution of recombinant human tumor necrosis factor-a in rats. Lymphokine Cytokine Res. 1991; 10(-4-):301-306. >>> Tumor necrosis factor; Radio-isotopes; 125I tracer; SC; rat; 2001; no duration posted; peptides; half-life; TNF plasma clearance and distribution.

P2449 Vyalov,S., Desmouliere,A., Gabbiani,G. GM-CSF-induced granulation tissue formation: relationships between macrophage and myofibroblast accumulation. Virchows Archiv B Cell Pathol. 1993; 63(--):231-239. >>> Colony-stimulating factor, GM; Tumor necrosis factor; Platelet-derived growth factor; Saline; SC; rat; 2001; 2-7 days; controls received mp w/ TNF, PDGF or carrier solution; functionality of mp verified upon removal; pump infused GM-CSF to study formation of granulation tissue at infusion site; recomb. murine TNF used.

P2278 Gerasimidi,A., Sheehan,K.C.F., Schreiber,R.D., Lacy,P.E. Tumor necrosis factor-a prevents rejection of islet xenografts (rat to mouse). Diabetes 1993; 42(--):651-657. >>> Tumor necrosis factor-a; Saline; IP; SC; mice; 2001; 7 days; controls received mp w/saline; comparison of sc injections vs mp; stress/adverse reaction: necrosis, p.653; ip administration of TNF killed most mice within 3-4 days; recomb. murine TNF used.

P2261 Fajardo,L.F., Kwan,H.H., Kowalski,J., Prionas,S.D., Allison,A.C. Dual role of tumor necrosis factor-a in angiogenesis. Am.J.Pathol. 1992; 140(--):539-544. >>> Tumor necrosis factor-a; PBS; SC; mice; 2002; 14 days; controls received mp w/PBS; peptides; pump implanted within 5mm of disc angiogenesis system (DAS); recomb. murine TNF used.

P2192 Desmouliere,A., Rubbia-Brandt,L., Grau,G., Gabbiani,G. Heparin induces a-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts. Lab.Invest. 1992; 67(-6-):716-726. >>> ITF-1158; SR-80258A; Heparin; Tumor necrosis factor-a; Saline; SC; rat; 2002; 14 days; controls received mp w/vehicle; functionality of mp verified by residual volume upon explantation; ITF-1158 and SR-80258A are heparin derivatives.

P2191 Desmouliere,A., Geinoz,A., Gabbiani,A., Gabbiani,G. Transforming growth factor-B1 induces a-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J.Cell Biol. 1993; 122(-1-):103-111. >>> Transforming growth factor-B1; Tumor necrosis factor-a; Saline; SC; rat; 2001; 7 days; controls received mp w/saline; functionality of mp verified upon removal; peptides; recomb. human TGF-B1 used; recomb. murine TNF used.

P2162 Sweep,C.G.J., Van der Meer,M.J.M., Ross,H.A., Vranckx,R., Visser,T.J., Hermus,A.R.M.M. Chronic infusion of TNF-a reduces plasma T4 binding without affecting pituitary-thyroid activity in rats. Am.J.Physiol. 1992; 263(-26-):E1099-E1105. >>> Tumor necrosis factor-a; Saline; IP; rat; 2001; 7 days; no stress (see pg. 1100); peptides.

P2133 Sweep,C.G.J., Hermus,A.R.M.M., Van der Meer,M.J.M., Demacker,P.N.M., Benraad,T.J., Kloppenborg,P.W.C., van der Meer,J.W.N. Chronic intraperitoneal infusion of low doses of tumor necrosis factor a in rats induces a reduction in plasma triglyceride levels. Cytokine 1992; 4(-6-):561-567. >>> Tumor necrosis factor-a; Saline; IP; rat; 2001; 7 days; controls received mp with saline; no stress (see p. 565); peptides.

P2020 Brahn,E., Peacock,D.J., Banquerigo,M.L., Liu,D.Y. Effects of tumor necrosis factor alpha (TNF-a) on collagen arthritis. Lymphokine Cytokine Res. 1992; 11(-5-):253-256. >>> Tumor necrosis factor-a; Albumin, bovine serum; Water; rat; 2ML4; 28 days; peptides.

P1999 Denis,M. Involvement of cytokines in determining resistance and acquired immunity in murine tuberculosis. J.Leukoc.Biol. 1991; 50(--):495-501. >>> Interferon-gamma, inactivated; Tumor necrosis factor-a; Interferon-gamma; Interleukin-2; Interleukin-2, inactivated; Tumor necrosis factor-a, inactivated; IP; mice; 2002; no duration posted; peptides.

P1925 Kahky,M.P., Daniel,C.O., Cruz,A.B., Gaskill,H.V. Portal infusion of tumor necrosis factor increases mortality in rats. J.Surg.Res. 1990; 49(--):138-145. >>> Tumor necrosis factor; Albumin, rat serum; Heparin; PBS; IV (anterior mesenteric); IV (iliolumbar); rat; 2ML1; 7 days; controls received pumps with vehicle only; cancer; peptides; states TNF much more toxic via intraportal administration; 100 U/ml of heparin; animal info (m, Fischer-344, 175-200 g).

P1823 Piguet,P.F., Grau,G.E., Vassalli,P. Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis. Am.J.Pathol. 1990; 136(-1-):103-110. >>> Tumor necrosis factor; Hank's solution; Penicillin; Streptomycin sulfate; SC; mice; 2001; 2002; 7 days; controls received pumps with saline only; tissue perfusion (skin); local perfusion of skin using a catheter.

P1553 Miller,K.L., Silverman,P.H., Kullgren,B., Mahlmann,L.J. Tumor necrosis factor alpha and the anemia associated with murine malaria. Infect.Immun. 1989; 57(-5-):1542-1546. >>> Tumor necrosis factor; Culture medium, RPMI 1640; SC; mice; 2001; 6, 7 days; cancer/immunology; peptides; recomb. human&murine TNF used.

P1441 Kindler,V., Sappino,A.-P., Grau,G.E., Piguet,P.-F., Vassalli,P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989; 56(--):731-740. >>> Tumor necrosis factor; Saline; IP; mice; 2002; 20 days; peptides; cancer/immunology.

P1418 Gaskill III,H.V. Continuous infusion of tumor necrosis factor: mechanisms of toxicity in the rat. J.Surg.Res. 1988; 44(--):664-671. >>> Tumor necrosis factor, human; Prostaglandin E1; Albumin, rat serum; Saline; Triacetin; IP; rat; 2ML1; 5 days; Multiple pumps per animal (2); PGE1 and TNF concomitantly infused; cancer/immunology; toxicology/teratology; peptides.

P1377 Socher,S.H., Friedman,A., Martinez,D. Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice. J.Exp.Med. 1988; 167(--):1957-1962. >>> Tumor necrosis factor; Albumin, bovine serum; Saline; IP; mice; 2002; 14 days; dose-response (text, graph); half-life; tolerance developed to TNF infusion; comparison of IP injections vs. mp infusion; functionality of mp verified by serum levels; cancer/immunology; peptides.

P0909 Clark,I.A., Hunt,N.H., Butcher,G.A., Cowden,W.B. Inhibition of murine malaria (plasmodium chabaudi) in vivo by recombinant interferon-gamma or tumor necrosis factor, and its enhancement by butylated hydroxyanisole. J.Immunol. 1987; 139(-10-):3493-3496. >>> Tumor necrosis factor; Saline; IP; SC; mice; 2001; 7 days; controls received mp w/ saline; mice injected with malarial parasites; 2 doses of agent infused; concomitant administration of rIFN; immunology; peptides.

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29. Tumor Necrosis Factor

16001 Liguz-Lecznar, M., Zakrzewska, R., Kossut, M. Inhibition of Tnf-alpha R1 signaling can rescue functional cortical plasticity impaired in early post-stroke period. Neurobiol Aging 2015; 36(-10-):2877-84. >>> Tumor necrosis factor-a receptor 1, soluble; CSF/CNS; Mice; 1007D; Controls received mp w/ saline; animal info (female, C57BL6J, 1 year old); ALZET brain infusion kit 3 used; ischemia (cerebral); Dose (1 ug/day); brain coordinates;.

14900 Cunningham, MW Jr, West, C.A., Wen, X.R., Deng, A.H., Baylis, C., Cunningham, MW Jr. Pregnant rats treated with a high-fat/prooxidant Western diet with ANG II and TNF-alpha are resistant to elevations in blood pressure and renal oxidative stress. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 308(--):R945-R956. >>> Angiotensin II; tumor necrosis factor, alpha; SC; Rat (pregnant); 2ML2; Controls received mp w/ saline; animal info (female, Sprague Dawley, 15-21 weeks, day 6 of pregnancy); cardiovascular; peptides;.

14632 Matsuda, T., Murao, N., Katano, Y., Juliandi, B., Kohyama, J., Akira, S., Kawai, T., Nakashima, K., Nakashima, K. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nature Communications 2015; 6(--):U26-U35. >>> Tumor necrosis factor, alpha, recomb.; CSF/CNS; Mice; animal info (TLR9-KO).

14596 Toyoizumi, T., Kaneko, M., Stryker, M.P., Miller, K.D., Toyoizumi, T. Modeling the Dynamic Interaction of Hebbian and Homeostatic Plasticity. Neuron 2014; 84(--):497-510. >>> Tumor necrosis factor receptor 1; CSF/CNS (cortex); Mice; 1002; Control animals received mp w/ vehicle; animal info (C57BL/6, male).

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“Angiostatin was administered through continuous infusion...the continuous administration of angiogenesis inhibitors has greater therapeutic efficacy than the more commonly used twice-daily injections.” (p. 80) Reijneveld et al., European Journal of Clinical Investigation 2003;33:76-81.