References on the Administration of Deoxycorticosterone Using ALZET® Osmotic Pumps

3347 Lobo, M.J., Remesar, X., Alemany, M. Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Biochem. Molec. Biol. Intl 1993; 29(-2-):349-358. >>> Progesterone; Cortisol; Cortisone; Corticosterone; Dehydroepiandrosterone; Androstenedione, 4-; Androstendiol, 5-; Testosterone; Nortestosterone, 19-; Estradiol, B-; Estrone; Estriol; Deoxycorticosterone; PEG 400; IV (lower cava); rat; 2002; controls received mp with PEG; no stress (see pg. 351); pumps placed into peritoneal cavity and sutured to musculature; surgical wound sprinkled with sulphathiazol.

612 Phillips, R., Crock, C., Funder, J. Effect of mineralocorticoids and glucocorticoids on compensatory adrenal growth in rats. Am. J. Physiol 1985; 248(-4-):E450-E456. >>> Aldosterone; Fluorocortisol acetate, 9a-; Corticosterone; Deoxycorticosterone; Dexamethasone; Ethanol; Propylene glycol; Water; SC; rat; replacement therapy (unilateral adrenalectomy); each mp used twice, 3 days in one animal, then 3 days in another; cannot tell if stability/concentration of ald. determined by RIA before or after exp.

194 Komanicky, P., Melby, J.C. Hypertensinogenic potencies of aldosterone and deoxycorticosterone in the rat. Hypertension 1982; 4(-1-):140-145. >>> Aldosterone acetate; Deoxycorticosterone acetate; Ethanol; Propylene glycol; Water; SC; rat; 1701; additional pump implanted after 7 and 14 days adjacent to the'spent'pumps.

182 Carroll, J., Komanicky, P., Melby, J.C. The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat. J. Steroid Biochem 1981; 14(--):989-995. >>> Deoxycorticosterone, 18-OH-; Deoxycorticosterone acetate, 11-; Ethanol; Propylene glycol; Water; SC; rat; pumps replaced on days 7&14 in Exp. 1.

140 Carroll, J., Komanicky, P., Melby, J.C. 5a-dihydro-11-deoxycorticosterone: effect on blood pressure in the rat. Steroids 1981; 37(-1-):111-120. >>> Deoxycorticosterone acetate; Deoxycorticosterone acetate, 11-; Deoxycorticosterone, 5a-dihydro-; Deoxycorticosterone, 5a-dihydro-11-; Ethanol; Propylene glycol; SC; rat; no comment posted.

61 Will, P.C., Cortright, R.N., Hopfer, U. Polyethylene glycols as solvents in implantable osmotic pumps. J. Pharm. Sci 1980; 69(-6-):747-749. >>> Aldosterone; Corticosterone; Deoxycorticosterone acetate; Dexamethasone acetate; Estradiol, 17B-; Hydrocortisone; Progesterone; Spironolactone; Testosterone; PEG; PEG 400; PEG 600; IP; rat; 1701; 3-7 days aldosterone, 6 days PEG only; replacement therapy (adrenalectomy).


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What researchers are saying...

“In order to investigate the in vivo role of MMPs, we established a rodent model of glioma progression... We chose continuous infusion using an osmotic pump as the method for delivering TIMP into the tumor. This paradigm allowed aggressive glioma development and circumvented the problem of the blood brain barrier disturbing reagent delivery following intravenous delivery.” Takahashi et al., Pharmacological Research 2002;46(2):155-163.