References on the Administration of Dexamethasone Using ALZET^® Osmotic Pumps

Q0896 Rafiq,K., Nakano,D., Ihara,G., Hitomi,H., Fujisawa,Y., Ohashi,N., Kobori,H., Nagai,Y., Kiyomoto,H., Kohno,M., Nishiyama,A. Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats. Journal of Hypertension 2011; 29(-2-):290-298. >>> Hydrocortisone; dexamethasone; SC; Rat; 2004; 8 weeks; Controls received mp w/ vehicle; animal info (male, Wistar-Kyoto, 160-183 g, uninephrectomy, bilateral adrenalectomy); long-term study; pumps replaced after 4 weeks; blood pressure (SBP) was measured by tail plethysmography (BP-98A; Softron Co., Tokyo, Japan).

Q0344 Henderson,WR Jr, Chi,E.Y., Ye,X., Nguyen,C., Tien,Y.T., Zhou,B.Y., Borok,Z., Knight,D.A., Kahn,M. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-32-):14309-14314. >>> Dexamethasone; ICG-001; Saline; SC; Mice; 2001; 10, 21 days; Controls received mp w/ vehicle; animal info (C57BL/6, BAT-gal transgenic).

Q0321 Yao,X.L., Fredriksson,K., Yu,Z.X., Xu,X.L., Raghavachari,N., Keeran,K.J., Zywicke,G.J., Kwak,M., Amar,M.J.A., Remaley,A.T., Levine,S.J. Apolipoprotein E Negatively Regulates House Dust Mite-induced Asthma via a Low-Density Lipoprotein Receptor-mediated Pathway. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2010; 182(-10-):1228-1238. >>> Dexamethasone; apolipoprotein E (130-149), mimetic; Mice; 2004; 3 weeks; Controls received mp w/ apolipoprotein E scrambled, or saline); animal info (female A/J, C57BL/6, apo E-/-, LDLR-/-, 6-8 wk old); peptides;.

P9986 Wu,Y., Zhao,W.D., Zhao,J.B., Zhang,Y.F., Qin,W.P., Pan,J.P., Bauman,W.A., Blitzer,R.D., Cardozo,C. REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss. Endocrinology 2010; 151(-3-):1050-1059. >>> Dexamethasone; testosterone; Propylene glycol; Rat; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 250 g.).

P9777 Giraud,S., Bessette,B., Boda,C., Lalloue,F., Petit,D., Mathonnet,M., Jauberteau,M.O. In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats. INTERNATIONAL JOURNAL OF ONCOLOGY 2007; 30(--):273-281. >>> Fas ligand; etoposide; dexamethasone; CSF, artificial; CSF/CNS (intratumoral); Rat (nude); 1002; 15 days; Tissue perfusion (tumor); functionality of mp verified by residual volume; cancer (glioblastoma); animal info (female 2 months old, 159 g.).

P9463 Willis,M.S., Rojas,M., Li,L., Selzman,C.H., Tang,R.H., Stansfield,W.E., Rodriguez,J.E., Glass,D.J., Patterson,C. Muscle ring finger 1 mediates cardiac atrophy in vivo. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-4-):H997-H1006. >>> Dexamethasone; DMSO; SC; Mice; 2002; 2 weeks; Comparison of SC injections vs. mp; cardiovascular; animal info (male, female, wt, MuRF1 -/-, 12-15 wks old); murine cardiac atrophy model; "osmotic pump experiments demonstrated a greater overall atrophy than the daily dexamethasone injections." (p. H1004).

P9442 Scholz,J., Abele,A., Marian,C., Haeussler,A., Herbert,T.A., Woolf,C.J., Tegeder,I. Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain 2008; 138(-1-):130-142. >>> Methotrexate; dexamethasone; CSF, artificial; PBS; CSF/CNS (intrathecal); Rat; 7, 14 days; Controls received mp w/ vehicle; dose-response (fig. 7); comparison of IP injections vs. mp; enzyme inhibitor (dihydrofolate reductase); animal info (male, Sprague Dawley, 160-200 g., SNI); behavioral testing (paw withdrawal, mechanical allodynia, cold allodynia); "sustained intrathecal treatment may therefore suppress microglial activation much more efficiently than intermittent high-dose bolus injections." (p. 140).

P9440 Saito,T., Saito,T., Kasono,K., Otani,T., Tamemoto,H., Kawakami,M., Sasaki,S., Ishikawa,S. Vasopressin-dependent upregulation of aquaporin-2 gene expression in aged rats with glucocorticoid deficiency. ACTA PHYSIOLOGICA 2009; 196(-2-):239-247. >>> Aldosterone; dexamethasone; SC; Rat; 2ML4; 17 days; Controls received mp w/ both agents; replacement therapy (adrenalectomy); animal info (male, Sprague Dawley, 6 wks old, 200-250 g.; 52 wks old, 650-700 g.); nephrology.

P9295 Zhao,W.D., Pan,J.P., Zhao,Z.B., Wu,Y., Bauman,W.A., Cardozo,C.P. Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulation. Journal of Steroid Biochemistry and Molecular Biology 2008; 110(-1-2-):125-129. >>> Testosterone; dexamethasone; Propylene glycol; Rat; 1, 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 250 g.).

P9292 Vivero,R.J., Joseph,D.E., Angeli,S., He,J., Chen,S.B., Eshraghi,A.A., Balkany,T.J., Van de Water,T.R. Dexamethasone Base Conserves Hearing from Electrode Trauma-Induced Hearing Loss. Laryngoscope 2008; 118(-11-):2028-2035. >>> Dexamethasone base; Perilymph, artificial; Ear (scala tympani); Guinea-pig; 2001; 8 days; Controls received mp w/ vehicle; replacement therapy (cochleostomy); tissue perfusion (scala tympani); animal info (pigmented, 250-300 g.).

P9106 van Haarst,A.D., Oitzl,M.S., Workel,J.O., de Kloet,E.R. Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity. Endocrinology 1996/11; 137(-11-):4935-4943. >>> RU38486; dexamethasone; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle; functionality of mp verified by injecting methylene blue into the pumps; animal info (male, Wistar, 180-200 g.); RU38486 is a glucocorticoid antagonist; behavioral testing (Morris water maze test).

P8703 Zhu,M.Y., Wang,W.P., Huang,J.J., Regunathan,S. Chronic treatment with glucocorticoids alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels. Journal of Neurochemistry 2007; 103(-5-):1811-1820. >>> Dexamethasone; agmatine; Saline; SC; Rat; 7, 21 days; Controls received mp w/ vehicle; dose-response (fig. 4); animal info (male, Sprague-Dawley, 250-300g); "One advantage of this study is the use of osmotic mini-pump... to ensure consistent elevations over 24-h cycle (sic)." (p. 1818).

P8577 Grossmann,C., Krug,A.W., Freudinger,R., Mildenberger,S., Voelker,K., Gekle,M. Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am.J.Physiol Endocrinol.Metab 2007/6; 292(-6-):E1790-E1800. >>> Aldosterone; dexamethasone; DMSO; Rat; 2ML1; 6 days; Controls received mp w/ vehicle; functionality of mp verified by plasma concentrations; replacement therapy (adrenalectomy); animal info (male, Munich-Wistar, 200-250 grams); endocrinology.

P8457 Clarke,B.A., Drujan,D., Willis,M.S., Murphy,L.O., Corpina,R.A., Burova,E., Rakhilin,S.V., Stitt,T.N., Patterson,C., Latres,E., Glass,D.J. The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metabolism 2007; 6(-5-):376-385. >>> Dexamethasone; Saline; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; animal info (MuRF1 -/- or wt, 3 months old, 25-30g).

P8103 Dickinson,H., Walker,D.W., Wintour,E.M., Moritz,K. Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2007; 292(-1-):R453-R461. >>> Dexamethasone; SC; Mice (pregnant); 1003D; 60 hours; Controls received mp w/ saline; no stress (see p.R455); good methods p.R454; teratology; post op. care (xylocaine, betadine); animal info (female, gestation day 20); nephrology.

P8037 Wu,G.J., Wen,Z.H., Chen,W.F., Chang,Y.C., Cherng,C.H., Wong,C.S. The effect of dexamethasone on spinal glutamine synthetase and glutamate dehydrogenase expression in morphine-tolerant rats. Anesthesia and Analgesia 2007; 104(-3-):726-730. >>> Morphine; dexamethasone; CSF/CNS (intrathecal); Rat; 2001; 5 days; Animal info (male, Wistar, 350-370 grams).

P7859 de Seigneux,S., Kim,S.W., Hemmingsen,S.C., Frokiaer,J., Nielsen,S. Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome. American Journal of Physiology-Renal Physiology 2006; 291(-1-):F208-F217. >>> Dexamethasone; DMSO; saline, isotonic; SC; Rat; 2002; 14 days; Animal info (Hannover-Wistar, male, 240-250g.); mp primed 4 hours in saline.

P7771 Henderson,WR Jr, Chiang,G.K.S., Tien,Y.T., Chi,E.Y. Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006; 173(-7-):718-728. >>> Montelukast sodium; dexamethasone; SC; Mice; 2004; 90 days; Controls received mp w/ saline; pumps replaced every 30 days; animal info (female, BALB/C, 6-8 wk old).

P7684 Moussy,Y, Hersh,L, Dungel,P  Biotechnol.Prog. 2006; 22(--):819-824. >>> Dexamethasone; Saline, sterile; radio-isotopes; 3H tracer; SC; Rat; 1003D; ; Good methods p. 820; animal info (male, Sprague-Dawley, 375-399 g); distribution study using auto radiography, agent distributed as far as 3 mm near catheter tip; catheter length was 4 cm's to avoid tissue irritation variables near pump; tissue distribution.

P7496 Fenton,R.A., Shodeinde,A., Knepper,M.A. UT-A urea transporter promoter, UT-A alpha, targets principal cells of the renal inner medullary collecting duct. American Journal of Physiology-Renal Physiology 2006; 290(-1-):F188-F195. >>> Dexamethasone; DMSO; saline, isotonic; SC; Mice (transgenic); 2001; 6 days; Controls received mp w/ vehicle; animal info (male, C57BL6); 20% DMSO.

P7414 Wen,Z.H., Wu,G.J., Chang,Y.C., Wang,J.J., Wong,C.S. Dexamethasone modulates the development of morphine tolerance and expression of glutamate transporters in rats. Neuroscience 2005; 133(-3-):807-817. >>> Dexamethasone; morphine; CSF/CNS (intrathecal, occipital); Rat; 2001; 5 days; Controls received mp w/ saline or dex; animal info (male, wistar, 400-500 g).

P7177 Crowley,S.D., Gurley,S.B., Oliverio,M.I., Pazmino,A.K., Griffiths,R., Flannery,P.J., Spurney,R.F., Kim,H.S., Smithies,O., Le,T.H., Coffman,T.M. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. Journal of Clinical Investigation 2005; 115(-4-):1092-1099. >>> Aldosterone; dexamethasone; PEG 400; saline, normal; SC; Mice; 2004; ; Replacement therapy (adrenalectomy, nephrectomy).

P7129 Liu,Y., Imai,H., Sadamatsu,M., Tsunashima,K., Kato,N. Cytokines participate in neuronal death induced by trimethyltin in the rat hippocampus via type II glucocorticoid receptors. NEUROSCIENCE RESEARCH 2004; 50(--):209-217. >>> Aldosterone; dexamethasone; SC; Rat; 11,21 days; Controls received sham operation; replacement therapy (adrenalectomy).

P6993 Thomas,M., Keramidas,M., Monchaux,E., Feige,J.J. Dual hormonal regulation of endocrine tissue mass and vasculature by adrenocorticotropin in the adrenal cortex. Endocrinology 2004; 145(-9-):4320-4329. >>> Dexamethasone; ACTH (1-39), human; Cyclodextrin; SC; Mice; 2002; 1-14 days; Controls received mp w/ vehicle; functionality of mp verified by plasma ACTH and corticosterone levels; multiple pumps per animal (2).

P6807 Christie,P.E., Jonas,M., Tsai,C.H., Chi,E.Y., Henderson,WR Jr  European Respiratory Journal 2004; 24(-1-):107-115. >>> Dexamethasone; SC; Mice; 2004; 50 days; Controls received mp w/ saline; long-term study; pumps replaced after 28 days; no stress (see pg. 110); Asthma.

P6752 Narayanan,N., Yang,C.X., Xu,A. Dexamethasone treatment improves sarcoplasmic reticulum function and contractile performance in aged myocardium. MOLECULAR AND CELLULAR BIOCHEMISTRY 2004; 266(-1-2-):31-36. >>> Dexamethasone; SC; Rat; 2001; 5 days; Controls received mp w/ vehicle; good methods (p.32); cardiovascular.

P6605 Gertner,R.A., Klein,J.D., Bailey,J.L., Kim,D.U., Luo,X.H., Bagnasco,S.M., Sands,J.M. Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor. Journal of the American Society of Nephrology 2004; 15(-3-):558-565. >>> Aldosterone; spironolactone; dexamethasone; Saline; DMSO; SC; Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy);<10% DMSO used.

P6433 Zhang,R.X., La,L.X., Qiao,J.T., Malsnee,K., Ruda,M.A. Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation. Neuroscience Letters 2004; 359(-1-2-):85-88. >>> Dexamethasone; Propylene glycol; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); half-life (p. 86) 36-72 hours.

P6293 Lu,R., Kanai,N., Bao,Y., Wolkoff,A.W., Schuster,V.L. Regulation of renal oatp mRNA expression by testosterone. American Physiological Society 1996; (--):F332-F337. >>> Testosterone; estradiol; dexamethasone; PEG 600; PEG; SC; Rat; 2001; 1 week; Controls received mp w/ vehicle; replacement therapy (gonadectomy, adrenalectomy, orchidectomy, oophorectomy).

P6267 Ader,I., Delmas,C., Bonnet,J., Rochaix,P., Favre,G., Toulas,C., Cohen-Jonathan-Moyal,E. Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts. ONCOGENE 2003; 22(-55-):8861-8869. >>> Dexamethasone; SC; 6 days; Cancer (glioblastoma); transplantation; pump and animal model not listed.

P6252 Langdown,M.L., Holness,M.J., Sugden,M.C. Effects of prenatal glucocorticoid exposure on cardiac calreticulin and calsequestrin protein expression during early development and in adulthood. Biochemical Journal 2003; 371(--):61-69. >>> Dexamethasone sodium phosphate; Rat (pregnant); 2001; 7 days; Dose-response (Table 1); cardiovascular; teratology; priming dose of agent given by SC injection prior to mp implantation.

P6144 Kwon,T.H., Nielsen,J., Masilamani,S., Hager,H., Knepper,M.A., Frokiaer,J., Nielsen,S. Regulation of collecting duct AQP3 expression: response to mineralocor ticoid. American Journal of Physiology-Renal Physiology 2002; 283(-6-):F1403-F1421. >>> Aldosterone; dexamethasone; DMSO; saline; SC; Rat; 2002; 10 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P6120 Krug,A.W., Papavassiliou,F., Hopfer,U., Ullrich,K.J., Gekle,M. Aldosterone stimulates surface expression of NHE3 in renal proximal br ush borders. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2003; 446(-4-):492-496. >>> Aldosterone; dexamethasone; SC; Rat; 2ML1; 5 days; Functionality of mp verified by aldosterone plasma levels; replacement therapy (adrenalectomy).

P5985 de la Rosa,D.A., Coric,T., Todorovic,N., Shao,D.R., Wang,T., Canessa,C.M. Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney. JOURNAL OF PHYSIOLOGY-LONDON 2003; 551(-2-):455-466. >>> Dexamethasone; SC; Rat; 2002; 1 week; Replacement therapy (adrenalectomy).

P5941 Benedetti,S., Pirola,B., Poliani,P.L., Cajola,L., Pollo,B., Bagnati,R., Magrassi,L., Tunici,P., Finocchiaro,G. Dexamethasone inhibits the anti-tumor effect of interleukin 4 on rat experimental gliomas. Gene Therapy 2003; 10(-2-):188-192. >>> Dexamethasone; SC; Rat; 2002; 2ML4; 14,28 days; Dex plasma levels taken; cancer (glioma).

P5552 Boulkroun,S., Fay,M., Zennaro,M.C., Escoubet,B., Jaisser,F., Blot-Chabaud,M., Farman,N., Courtois-Coutry,N. Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. Journal of Biological Chemistry 2002; 277(-35-):31506-31515. >>> Dexamethasone; Rat; 1007D; 7 days; Replacement therapy (adrenalectomy).

P5481 Himeno,C., Komeda,M., Izumikawa,M., Takemura,K., Yagi,M., Yang,W.P., Doi,T., Kuriyama,H., Miller,J.M., Yamashita,T. Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hearing Research 2002; 167(-1-2-):61-70. >>> Dexamethasone; Perilymph, artificial; Ear (cochlea); guinea-pig; 2002; 14, 28 days; Controls received mp w/ vehicle; pumps replaced after 14 days; no stress (see pg. 67); "The current study indicates that intra-cochlear administration using osmotic pumps can provide a stable and continuous delivery of Dexamethasone without causing functional changes or tissue damage." (p. 67); tissue perfusion (cochlea).

P5429 Nielsen,J., Kwon,T.H., Masilamani,S., Beutler,K., Hager,H., Nielsen,S., Knepper,M.A. Sodium transporter abundance profiling in kidney: effect of spironolactone. American Journal of Physiology-Renal Physiology 2002; 283(-5-):F923-F933. >>> Dexamethasome; aldosterone, D-; DMSO; saline, sterile; SC; Rat; 2002; 10 days; Replacement therapy (adrenalectomy).

P5405 Val,P., Martinez,A., Sahut-Barnola,I., Jean,C., Veyssiere,G., Lefrancois-Martinez,A.M. A 77-base pair LINE-Like sequence elicits androgen-dependent mvdp/akr1-b7 expression in mouse vas deferens, but is dispensable for adrenal expression in rats. Endocrinology 2002; 143(-9-):3435-3448. >>> Testosterone; Dexamethasone acetate; Cyclodextrin; PEG; SC; Rat; 2001; 2002; 8, 10 days; Replacement therapy (orchidectomy); testosterone dissolved in cyclodextrin solution and delivered for 10 days via 2002 pumps; dexa was infused via 2001 pumps in PEG vehicle; animal info (adult, male, Wistar).

P5224 Rao,M.K., Xu,A., Narayanan,N. Glucocorticoid modulation of protein phosphorylation and sarcoplasmic reticulum function in rat myocardium. Am.J Physiol Heart Circ.Physiol 2001/7; 281(-1-):H325-H333. >>> Dexamethasone; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; replacement therapy (adrenalectomy p. H326); cardiovascular.

P5120 Sahlin,L., Elger,W., Hedden,A., Lindberg,M., Reddersen,G., Schneider,B., Schwarz,S., Freyschuss,B., Eriksson,H. Effects of estradiol and estradiol sulfamate on the liver of ovariectomized or ovariectomized and hypophysectomized rats. Journal of Steroid Biochemistry and Molecular Biology 2002; 80(--):457-467. >>> Estradiol, 17B-; Estradiol sulfamate; Dexamethasone; Growth hormone, human; Propylene glycol; SC; rat; 2001; 7 days; controls received mp w/ vehicle; replacement therapy (ovariectomy, hypophysectomy, p. 458); comparison of oral administration vs. mp; steroid administered in PG, human GH pre-formulated.

P4939 Bailey,M.A., Unwin,R.J., Shirley,D.G. In vivo inhibition of renal 11-beta-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption. Clinical Science 2001; 101(--):195-198. >>> Aldosterone; Dexamethasone; SC; rat; 2002; 8-12; functionality of mp verified by plasma aldosterone levels; replacement therapy (adrenalectomy p.195); "the plasma concentration of aldosterone achieved via osmotic minipump is just suficient to maintain the rats in good health without causing over-stimulation." p. 197; mineralocorticoids.

P4929 Imai,H., Nishimura,T., Sadamatsu,M., Liu,Y., Kabuto,M., Kato,N. Type II glucocorticoid receptors are involved in neuronal death and astrocyte activation induced by trimethyltin in the rat hippocampus. Experimental Neurology 2001; 171(--):22-28. >>> Dexamethasone; Aldosterone; SC; rat; 21 days; controls received sham surgery; replacement therapy (adrenalectomy); corticosterone pellets also used;.

P4906 Holness,M.J., Sugden,M.C. Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver. Endocrinology 2001; 142(-9-):3742-3748. >>> Dexamethasone; SC; rat (pregnant); 5 days; controls received sham surgery; administration of dexamethasone was from day 14 to day 19 of gestation; "priming" SC injection of dexamethasone given before pump implantation; insulin resistance, diabetes;.

P4885 Attmane-Elakeb,A., Sibella,V., Vernimmen,C., Belenfant,X., Hebert,S.C., Bichara,M. Regulation by glucocorticoids of expression and activity of rBSC1, the Na+-K+ (NH4+)-2Cl(-) cotransporter of medullary thick ascending limb. Journal of Biological Chemistry 2000; 275(--):33548-33553. >>> Dexamethasone; SC; rat; 6 days; controls received sham adrenalectomy; functionality of mp verified by plasma electrolyte levels; replacement therapy (adrenalectomy); dexamethasone dose restores normal glucocorticoid activity after adrenalectomy, controls electrolyte levels..

P4830 Yang,G.S.Y., Song,H.T., Keithley,E.M., Harris,J.P. Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss.. American Journal of Otology 2000; 21(--):499-504. >>> Dexamethasone;; PBS;; Ear (round window membrane);; guinea-pig;; 2002;; ; Controls received mp w/ vehicle; tissue perfusion (bulla); comparison of IP injections vs. mp; multiple pumps per animal (2) (one containing dexamethasone for one ear, the other containing PBS for the other ear);.

P4801 Langdown,M.L., Holness,M.J., Sugden,M.C. Early growth retardation induced by excessive exposure to glucocorticoids in utero selectively increases cardiac GLUT1 protein expression and Akt/protein kinase B activity in adulthood.. Journal of Endocrinology 2001; 169(--):11-22. >>> Dexamethasone;; SC;; rat (pregnant);; 7 days;; Controls received sham surgery; cardiovascular; teratology; dexamethasone causes excess glucocorticoid exposure (causes hypertension and hyperinsulinemia)..

P4545 Sato,M., Dobashi,H, Ohye,H., Akiyama,T, Kawanishi,J, Kaji,Y, Mori,S, Takahara,J. Effect of growth hormone on growth failure and bone loss induced by supraphysiologic dose of glucocorticoid in rats.. Endocrine Journal 1999/1; 46(--):S89-S92. >>> Dexamethasone;; Saline;; SC;; rat;; 2004;; 28 days;; controls received mp w/vehicle;.

P4207 Shimoda,K., Nomura,M., Kato,M. Effect of antioxidants, anti-inflammatory drugs, and histamine antagonists on Sparfloxacin-induced phototoxicity in mice. Fundam.Appl.Toxicol. 1996; 31(--):133-140. >>> Catalase; Dimethyl sulfoxide; Dexamethasone; Indomethacin; Pyrilamine maleate; AA-861; Cimetidine; Phenidone; Ethanol; Saline; SC; mice; 1007D; 72 hours; all agents infused concomitantly in the same pump; preliminary study conducted to test solubility and toxicity for 5 days; enzyme inhibitors; toxicology.

P4168 Velazquez,H., Bartiss,A., Bernstein,P., Ellison,D.H. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am.J.Physiol.(Renal Fluid Electrolyte Physiol.39) 1996; 270(--):F211-F219. >>> Aldosterone; Dexamethasone; Ethanol; Saline; IP; rat; 2ML1; 3-5 days; replacement therapy (adrenalectomy); steroids infused singly or concomitantly.

P4041 Saito,T., Ishikawa,S.-E., Ando,F, Higashiyama,M, Nagasaka,S, Sasaki,S., Saito,T. Vasopressin-dependent upregulation of aquaporin-2 gene expression in glucocorticoid-deficient rats.. Am.J.Physiological.Renal Physiol. 2000; 279(--):F502-F508. >>> Aldosterone; Dexamethasone;; SC;; rat;; 2ML4;; 7 days;; Controls received mp with Aldosterone or Dexamethasone; replacement therapy (adrenalectomy); glucocorticoid;.

P3845 Slotkin,T.A., Thai,L., McCook,E.C., Saleh,J.L., Zhang,J., Seidler,F.J. Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase. J.Pharmacol.Exp.Ther. 1996; 279(-2-):478-491. >>> Dexamethasone; Water, bacteriostatic; SC; rat; 2ML4; 26 days; controls received mp w/vehicle; functionality of mp verified by serum levels; stability verified (pg. 1996).

P3832 Huang,T-S. Concomitant infusion of ovine corticotropin-releasing hormone does not prevent suppression of the hypothalamus-pituitary-adrenal axis by dexamethasone in male rats. J.Endocrinol.Invest. 1997; 20(--):393-396. >>> Dexamethasone; Corticotropin-rel. factor, ovine; SC; rat; 1003D; 2001; 3,7 days; replacement therapy; peptides.

P3689 Rudling,M., Olivecrona,H., Eggertsen,G., Angelin,B. Regulation of rat hepatic low density lipoprotein receptors. J.Clin.Invest. 1996; 97(-2-):292-299. >>> Growth hormone, recomb. human; Insulin-like growth factor I; Dexamethasone; Thyroxine, L-; rat; 2001; 2ML2; 6 days; controls received sham operation; replacement therapy (hypophysectomy); agent infusion rates given in ug/h; recomb. human IGF-I used.

P3660 Leopold,C.S., Friend,D.R. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J.Pharmacokinet.Biopharm. 1995; 23(-4-):397-406. >>> Dexamethasone; Dexamethasone-poly(L-aspartate); DMSO; intragastric; rat; 2001D; no duration posted; controls received mp w/ vehicle; dexamethasone-poly(L-aspartate) is an ester prodrug.

P3623 Tomas,F.M., Lemmey,A.B., Read,L.C., Ballard,F.J. Superior potency of infused IGF-1 analogues which bind poorly to IGF-binding proteins is maintained when administered by injection. J.Endocrinol. 1996; 50(--):77-84. >>> Insulin-like growth factor I; Insulin-like growth factor I, LR3-; Dexamethasone; SC; rat; 2001; 7 days; controls received mp w/ vehicle; comparison of sub-q injections vs. mp; peptides; recomb. human growth factors used; dexamethasone infused concomitantly w/ growth factors; "...continuous infusion of these peptides was clearly more effective than injection (P<0.001).", p. 79.

P3590 Simar,M.R., Saphier,D., Goeders,N.E. Dexamethasone suppression of the effects of cocaine on adrenocortical secretion in lewis and fischer rats. Psychoneuroendocrinology 1997; 22(-3-):141-153. >>> Dexamethasone; CSF, artificial;; CSF/CNS; IP; rat; 2002; 2 weeks; 16 days; controls received mp w/ aCSF; functionality of mp verified by plasma levels; dose response (dex); ALZET brain infusion kit used; glucocorticoid agonist; analyzed strain differences in response to agent; IP injections of cocaine.

P3401 Guo,W., Swaniker,F., Fonkalsrud,E.W., Vo,K., Karamanuokian,R. Effect of intraamniotic dexamethasone administration on intestinal absorption in a rabbit gastroschisis model. J.Pediatr.Surg. 1995; 30(-7-):983-987. >>> Dexamethasone; rabbit (pregnant); 2ML2; 6 days; dexamethasone delivered to fetus via catheter leading into amniotic fluid.

P3224 Ikeda,Y., Carson,B.S., Long,D.M. The effects of topical dexamethasone on experimental brain tumors and peritumoral brain edema. Acta Neurochir 1994; (-Supp 60-):397-399. >>> Dexamethasone; CSF/CNS (parietal lobe); rabbit; 2ML4; 6-10 days; cancer.

P3153 DeKrey,G.K., Kerkvliet,N.I. Effects of exogenous corticosterone treatment on alloantigen-specific cytotoxic T lymphocyte activity in mice. J.Pharmacol.Exp.Ther. 1995; 273(-2-):823-829. >>> Corticosterone; Dexamethasone; PEG 400; mice; 2002; 14 days; controls received mp with PEG; functionality of mp verified by plasma levels; immunology; agent infusion delayed 1 day after surgery (by using catheter tubing).

P3152 Van Put,D.J.M., Van Hove,C.E., De Meyer,G.R.Y., Wuyts,F., Herman,A.G., Bult,H. Dexamethasone influences intimal thickening and vascular reactivity in the rabbit collared carotid artery. Eur.J.Pharmacol. 1995; 294(--):753-761. >>> Dexamethasone; SC; rabbit; 2ML2; 14 days; controls received mp with saline; comparison of admin. in drinking water vs. mp; cardiovascular;.

P3120 Tonolo,G., Soro,A., Madeddu,P., Troffa,C., Melis,M.G., Patteri,G., Parpaglia,P.P., Sabino,G., Maioli,M., Glorioso,N. Effect of chronic intracerebroventricular dexamethasone on blood pressure in normotensive rats. Am.J.Pathol.(Endocrinol.Metab.27) 1993; 264(-27-):E843-E847. >>> Dexamethasone; CSF, artificial;; SC; CSF/CNS; rat; 2002; 24 days; controls received mp with vehicle; comparison of sc vs. icv infusion; pump replaced after 12 days; stability verified for 12-26 days; cannula placement confirmed by dipsogenic response to angiotensin II injections; good methods.

P3046 Walker,B.R., Williams,B.C., Edwards,C.R.W. Regulation of 11B-hydroxysteroid dehydrogenase activity by the hypothalamic-pituitary-adrenal axis in the rat. J.Endocrinol. 1994; 141(--):467-472. >>> Dexamethasone; NaCl; SC; rat; 9 days; controls received sham operation of vehicle.

P3008 Freyschuss,B., Sahlin,L., Masironi,B., Eriksson,H. The hormonal regulation of the oestrogen receptor in rat liver: an interplay involving growth hormone, thyroid hormones and glucocorticoids. J.Endocrinol. 1994; 142(--):285-298. >>> Growth hormone, human; Triiodothyronine, L-; Prolactin, ovine; Dexamethasone; SC; rat; 7 days; controls received hypophysectomy only w/ no mp; functionality of mp verified by checking pumps after usage; replacement therapy (hypophysectomy); comparison of single sc injections of GH&T3 vs. mp; agents given alone or in combination; growth hormone via mp partly restores liver estrogen receptor concentration while same dose in 2 single injections daily has no effect.

P2928 Rudling,M., Norstedt,G., Olivecrona,H., Reihner,E., Gustafsson,J.-A., Angelin,B. Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc.Natl.Acad.Sci.USA 1992; 89(--):6983-6987. >>> Growth hormone, human; Dexamethasone; Thyroxine, l-; SC; rat; 2001; 5 days; replacement therapy (hypophysectomy); peptides; GH given solely, or GH/Dex, GH/Dex/T4, or Dex/T4.

P2557 Baron,J., Klein,K.O., Colli,M.J., Yanovski,J.A., Novosad,J.A., Bacher,J.D., Cutler,G.B. Catch-up growth after glucocorticoid excess: a mechanism intrinsic to the growth plate. Endocrinology 1994; 135(-4-):1367-1371. >>> Dexamethasone phosphate; Hank's solution; bone (tibia); rabbit; 2ML4; 4 weeks; contralateral controls received mp w/ vehicle; tissue perfusion (bone).

P2481 Ikeda,Y., Carson,B.S., Lauer,J.A., Long,D.M. Therapeutic effects of local delivery of dexamethasone on experimental brain tumors and peritumoral brain edema. J.Neurosurg. 1993; 79(--):716-721. >>> Dexamethasone; intratumoral; rabbit; 6, 10 days; controls received no treatment; tissue perfusion (tumor); comparison of injections vs. mp; local vs. systemic treatment, graph pg. 719.

P2444 Tomas,F.M., Knowles,S.E., Owens,P.C., Chandler,C.S., Francis,G.L., Read,L.C., Ballard,F.J. Insulin-like growth factor-l and especially IGF-l variants are anabolic in dexamethasone-treated rats. Biochem.J. 1992; 282(--):91-97. >>> Insulin-like growth factor I; Dexamethasone sodium phosphate; Acetic acid; Saline; SC; rat; 2001; 7 days; controls received mp w/ vehicle; functionality of mp verified by plasma levels; peptides; multiple pumps per animal (2); growth factors and dexamethasone administered concomitantly; IGF-1, des(1-3) IGF-1, and LR3-IGF-1 used.

P2277 Geraci,J.P., Taylor,D.A., Mariano,M.S., Jackson,K.L. Effects of dexamethasone on the development of radiation nephropathy in the rat. Radiat.Res. 1992; 131(--):186-191. >>> Dexamethasone; SC; rat; 2ML4; 166 days; comparison of administration in drinking water vs. mp; long-term study, pumps replaced every 4 weeks; benefits of mp admin, p.190.

P2250 Eiam-Ong,S., Kurtzman,N.A., Sabatini,S. Effect of furosemide-induced hypokalemic metabolic alkalosis on renal transport enzymes. Kidney Int. 1993; 43(--):1015-1020. >>> Aldosterone; Dexamethasone; Furosemide; PEG 400; Saline; SC; rat; 2002; 7 days; replacement therapy (adrenalectomy); multiple pumps per animal (2); antihypertensive.

P2240 Deschepper,C.F., Dallman,M.F. The stimulation of liver angiotensinogen by glucocorticoids depends on the type of steroid and its mode of administration. Endocrinology 1992; 131(-5-):2371-2377. >>> Dexamethasone; SC; rat; 2001; 5 days; comparison of SC injections vs. mp.

P2216 ten Cate,W.J.F., Rarey,K.E. Plasma membrane modulation of ampullar dark cells by corticosteroids. Arch Otolaryngol.Head Neck Surg. 1991; 117(--):96-99. >>> Aldosterone; Dexamethasone; Propylene glycol; SC; rat; 2002; 14 days; controls received mp w/vehicle; animals were adrenalectomized.

P1865 Henriques,M.G.M.O., Weg,V.B., Martins,M.A., Silva,P.M.R., Fernandes,P.D., Cordeiro,R.S.B., Vargaftig,B.B. Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse. Br.J.Pharmacol. 1990; 99(--):164-168. >>> WEB 2086; Dexamethasone; mice; 2002; 48 hours; no comment posted.

P1851 Calogero,A.E., Liapi,C., Chrousos,G.P. Hypothalamic and suprahypothalamic effects of prolonged treatment with dexamethasone in the rat. J.Endocrinol.Invest. 1991; 14(--):277-286. >>> Dexamethasone; SC; rat; 1 week; dose-response; comparison of daily injections vs. mp.

P1704 Kenyon,C.J., Brown,W.B., Fraser,R., Tonolo,G., McPherson,F., Davies,D.L. Effects of dexamethasone on body fluid and electrolyte composition of rats. Acta Endocrinol.(Copenh) 1990; 122(--):599-604. >>> Dexamethasone; Sodium chloride; SC; rat; 2002; 2, 4 weeks; pumps replaced every 2 weeks.

P1692 Lovejoy,J., Wallen,K. Adrenal suppression and sexual initiation in group-living female rhesus monkeys. Horm.Behav. 1990; 24(--):256-269. >>> Dexamethasone sodium phosphate; SC; monkey; 2ML4; 24 days; controls received pumps with sterile water only; each animal received 2 pumps in succession with one week between pumps, behavioral study.

P1677 Sanjar,S., Aoki,S., Boubekeur,K., Burrows,L., Colditz,I., Chapman,I., Morley,J. Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs. Jpn.J.Pharmacol. 1989; 51(--):167-172. >>> Amlexanox; Azelastine; Cromoglycate; Ibudilast; Oxatomide; Tranilast; Aminophylline; Dexamethasone; Ketotifen; Saline, bacteriostatic; SC; guinea-pig; 2001; 6 days; no comment posted.

P1668 Doucet,A., Barlet-Bas,C., Siaume-Perez,S., Khadouri,C., Marsy,S. Gluco- and mineralocorticoids control adenylate cyclase in specific nephron segments. Am.J.Physiol. 1990; 258(--):F812-F820. >>> Aldosterone; Dexamethasone; SC; rat; no duration posted; no comment posted.

P1624 Sanjar,S., Aoki,S., Kristersson,A., Smith,D., Morley,J. Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of anti-asthma drugs. Br.J.Pharmacol. 1990; 99(--):679-686. >>> AH 21-122; Mepyramine; Aminophylline; Dexamethasone; Ketotifen; Salbutamol; Ethanol; PEG; SC; guinea-pig; 7 days; controls received pumps with either saline or vehicle.

P1559 Yagil,Y., Levin,M., Krakoff,L.R. Effect of glucocorticoid deficiency on arterial pressure in conscious spontaneously hypertensive rats. Am.J.Hypertens. 1989; 2(--):99-104. >>> Aldosterone; Dexamethasone; PEG 400; Saline; IP; rat; 2001; 6 days; functionality of mp verified by serum levels, urinary excretion; replacement therapy (adrenalectomy).

P1535 Stanton,B.A., Kaissling,B. Adaptation of distal tubule and collecting duct to increased Na delivery; II Na+ and K+ transport. Am.J.Physiol. 1988; 255(--):F1269-F1275. >>> Aldosterone; Dexamethasone; Furosemide; Saline; SC; rat; 2002; 2ML1; 6 days; Multiple pumps per animal (2); replacement therapy (adrenalectomy); antihypertensive.

P1534 Kaissling,B., Stanton,B.A. Adaptation of distal tubule and collecting duct to increased sodium delivery I; ultrastructure. Am.J.Physiol. 1988; 255(--):F1256-F1268. >>> Aldosterone; Dexamethasone; Furosemide; Vasopressin, arginine; Saline; SC; Rat; 2002; 2ML1; 6 days; Dose-response; multiple pumps per animal (2); functionality of mp verified by plasma levels; replacement therapy (adrenalectomy); antihypertensive.

P1477 Dallman,M.F, Levin,N., Cascio,C.S., Akana,S.F., Jacobson,L., Kuhn,R.W. Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors. Endocrinology 1989; 124(-6-):2844-2850. >>> Aldosterone; Dexamethasone; Propylene glycol; Saline; rat; 2001; 5 days; dose-response; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P1341 Edmonds,C.J., Willis,C.L. Aldosterone in colonic potassium adaptation in rats. J.Endocrinol. 1987; 117(--):379-386. >>> Aldosterone; Dexamethasone; IP; rat; 3 days; dose-response (text); replacement therapy (adrenalectomy).

P1332 Rutledge,J., Rabinowitz,L. Kaliuretic regulatory factors in the rat. Am.J.Physiol. 1987; 253(--):F1182-F1196. >>> Aldosterone; Dexamethasone; SC; rat; 2002; 14 days; controls; functionality of mp verified by plasma levels; replacement therapy (adrenalectomy).

P1329 Rebuffat,P., Belloni,A.S., Malendowicz,L.K., Mazzochi,G., Gottardo,G., Nussdorfer,G.G. Zona glomerulosa morphology and function in streptozotocin-induced diabetic rats. Endocrinology 1988; 123(-2-):949-955. >>> ACTH; Angiotensin II; Captopril; Dexamethasone; Insulin; Saline; SC; rat; 2002; 2 weeks; dose-response (text); functionality of mp verified by plasma levels; replacement t; antihypertensive therapy (streptozotocin-induced diabetes); peptides; antihypertensive.

P1327 Rabinowitz,L., Castonguay,T.W., Rutledge,J.C. Aldosterone reverses potassium-induced food aversions in adrenalectomized rats. Physiol.Behav. 1988; 42(--):137-140. >>> Aldosterone, d-; Dexamethasone; SC; rat; 2002; 14 days; sham operated controls; replacement therapy (adrenalectomy).

P1280 Rabinowitz,L., Berlin,R., Yamauchi,H. Plasma potassium and diurnal cyclic potassium excretion in the rat. Am.J.Physiol. 1987; 253(--):F1178-F1181. >>> Aldosterone; Dexamethasone; Saline; rat; 2002; 8, 18 days; replacement therapy (adrenalectomy).

P1191 Yagil,Y., Koreen,R., Krakoff,L.R. Role of mineralocorticoids and glucocorticoids in blood pressure regulation in normotensive rats. Am.J.Physiol. 1986; 251(--):H1354-H1360. >>> Aldosterone; Dexamethasone; PEG; Saline; IP; rat; 1701; 2001; no duration posted; controls received sham op or mp w/ vehicle; high salt diet; replacement therapy (adrenalectomy).

P1188 Halevy,J., Boulpaep,E.L., Budinger,M.E., Binder,H.J., Hayslett,J.P. Glucocorticoids have a different action than aldosterone on target tissue. Am.J.Physiol. 1988; 254(--):F153-F158. >>> Aldosterone; RU-28362; Dexamethasone; Ethanol; rat; 2001; no duration posted; controls received mp w/ vehicle.

P1186 Yagil,Y., Krakoff,L.R. The differential effect of aldosterone and dexamethasone on pressor responses in adrenalectomized rats. Hypertension 1988; 11(-2-):174-178. >>> Aldosterone; Dexamethasone; PEG; Saline; IP; rat; 1701; 2001; no duration posted; controls received mp w/ vehicle; dose-response (table); polyethylene glycol was used as vehicle for aldosterone; functionality of mp verified; replacement therapy (adrenalectomy).

P1108 Attallah,A. Effect of dexamethasone on rabbit renal prostaglandin E2 excretion: dependence on urinary flow. Eur.J.Pharmacol. 1987; 137(--):139-141. >>> Dexamethasone; SC; rabbit; 2ML1; 7 days; vehicle not specified.

P1104 Scandling,J.D., Ornt,D.B. Mechanism of potassium depletion during chronic metabolic acidosis in the rat. Am.J.Physiol. 1987; 252(--):F122-F130. >>> Aldosterone, d-; Dexamethasone; DMSO; IP; rat; 2001; 7 days; dose-response; agents infused separately; 2 mp per animal until day 4 when a 2nd aldosterone mp was implanted; replacement therapy (adrenalectomy).

P1014 Basile,A.S., Ostrowski,N.L., Skolnick,P. Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy. J.Pharmacol.Exp.Ther. 1987; 240(-3-):1006-1013. >>> Aldosterone acetate; Dexamethasone acetate; DMSO; Ethanol; Saline; SC; rat; 7 days; controls received mp w/vehicle; agents infused sep. with appropriate vehicle; sham-op animals implanted with mp containing vehicle only; replacement therapy (adrenalectomy).

P0999 Douglas,J.G. Corticosteroids decrease glomerular angiotensin receptors. Am.J.Physiol. 1987; 252(--):F453-F457. >>> Aldosterone; Dexamethasone sodium phosphate; Spironolactone; Ethanol; PEG; rat; 1701; 36 hours; controls received mp w/vehicle; agents infused separately with appropriate vehicles.

P0926 Naray-Fejes-Toth,A., Feges-Toth,Geza. Dexamethasone does not inhibit antidiuretic hormone-stimulated prostaglandin production in vivo. Endocrinology 1986; 119(-6-):2856-2860. >>> Dexamethasone; Saline; SC; rat; 2001; 7 days; controls received mp w/vehicle; diabetes; Vasopressin, 1-desamino-8-D arginine admin. on 5th day of mp infusion.

P0873 Kenyon,C.J., Clark,S.A., Hannah,J.A.M., Holloway,C.D., Ingram,M.C., Lindop,G., Towrie,A., Ball,S.G. The relative importance of glucocorticoids and mineralocorticoids in the development of adrenal regeneration hypertension in rats. Acta Endocrinol. 1986; 112(--):389-395. >>> Dexamethasone; SC; rat; 2002; 2 weeks; controls received mp w/ vehicle; hypertension.

P0845 Rabinowitz,L., Wydner,C.J., Smith,K.M., Yamauchi,H. Diurnal potassium excretory cycles in the rat. Am.J.Physiol. 1986; 250(--):F930-F941. >>> Aldosterone, d-; Dexamethasone; Ethanol; PEG; Saline; SC; rat; 2002; 3 days; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents.

P0656 van Zon,A.A.J.C., Eling,W.M.C., Schetters,T.P.M., Hermsen,C.C. ACTH-dependent modulation of malaria immunity in mice. Parasite Immunol. 1985; 7(-2-):107-117. >>> Cosyntropin; Corticosterone; Dexamethasone; Hank's solution; HEPES solution; PEG; SC; mice; 2002; no duration posted; comparison of agents effects; replacement therapy (adrenalectomy); tetracosactrin (cosyntropin) is a synthetic ACTH analog; dose-response data; immunology.

P0614 Garg,L.C., Narang,N., Wingo,C.S. Glucocorticoid effects of Na-K-ATPase in rabbit nephron segments. Am.J.Physiol. 1985; 248(-4-):F487-F491. >>> Dexamethasone sodium phosphate; rabbit; 2001; 1 week; replacement therapy (adrenalectomy); concentration of Dex. determined in plasma.

P0612 Phillips,R., Crock,C., Funder,J. Effect of mineralocorticoids and glucocorticoids on compensatory adrenal growth in rats. Am.J.Physiol. 1985; 248(-4-):E450-E456. >>> Aldosterone; Fluorocortisol acetate, 9a-; Corticosterone; Deoxycorticosterone; Dexamethasone; Ethanol; Propylene glycol; Water; SC; rat; 3 days; replacement therapy (unilateral adrenalectomy); each mp used twice, 3 days in one animal, then 3 days in another; cannot tell if stability/concentration of ald. determined by RIA before or after exp.

P0602 Higashihara,E., Kokko,J.P. Effects of aldosterone on potassium recycling in the kidney of adrenalectomized rats. Am.J.Physiol. 1985; 248(-2-):F219-F227. >>> Aldosterone; Dexamethasone; SC; rat; 2001; no duration posted; replacement therapy (adrenalectomy).

P0589 Basile,A.S., Paul,S.M., Skolnick,P. Adrenalectomy reduces the density of 'peripheral-type' binding sites for benzodiazepines in the rat kidney. Eur.J.Pharmacol. 1985; 110(--):149-150. >>> Aldosterone; Dexamethasone; Ethanol; Saline; SC; rat; 1 week; comparison of agents effects; replacement therapy (adrenalectomy); controls received mp w/vehicle.

P0587 Stanton,B., Janzen,A., Klein-Robbenhaar,G., DeFronzo,R., Giebisch,G., Wade,J. Ultrastructure of rat initial collecting tubule: effect of adrenal corticosteroid treatment. J.Clin.Invest. 1985; 75(--):1327-1334. >>> Aldosterone; Dexamethasone; PEG 400; SC; rat; 2002; 10 days; comparison of agents effects; replacement therapy (adrenalectomy); agents admin singly and in combination, 2 doses Ald. given.

P0586 Stanton,B., Giebisch,G., Klein-Robbenhaar,G., Wade,J., DeFronzo,R.A. Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney. J.Clin.Invest. 1985; 75(--):1317-1326. >>> Aldosterone; Dexamethasone; Radio-isotopes; 3H tracer; PEG 400; SC; rat; 2002; 7-9 days; comparison of agents effects; replacement therapy (adrenalectomy); agents given singly and in combination; 3H tracer used w/ Dex.

P0566 Will,P.C., Cortright,R.N., DeLisle,R.C., Douglas,J.G., Hopfer,U. Regulation of amiloride-sensitive electrogenic sodium transport in the rat colon by steroid hormones. Am.J.Physiol. 1985; 248(-1-):G124-G132. >>> Aldosterone; Corticosterone; Dexamethasone phosphate; Estradiol, 17B-; Progesterone; Testosterone; PEG 400; PEG 600; IP; rat; 1701; 2001; 3-8 days; comparison of agents effects; replacement therapy (adrenalectomy&ovariectomy); controls received mp with solvent or glass rods of mp size; no stress implied G125, weight regained; functionality of mp verified.

P0559 Shenker,Y., Villareal,J.Z., Sider,R.S., Grekin,R.J. a-Melanocyte-stimulating hormone stimulation of aldosterone secretion in hypophysectomized rats. Endocrinology 1985; 116(-1-):138-141. >>> ACTH(1-24); Dexamethasone disodium phosphate; Melanocyte-stimulating hormone, a-; Thyroxine, l-; SC; rat; 6 days; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0497 Norstedt,G. Effect of growth hormone on prolactin receptors and on estrogen receptors in the liver of prepubertal rats. Mol.Cell.Endocrinol. 1984; 36(--):195-200. >>> Dexamethasone; Growth hormone; SC; rat; 2001; 6 days; comparison of agents effects; vehicle not used alone in mp as control due to cost; GH deliv. alone and in combination w/ Dex; peptides.

P0484 Perrone,R.D., Jenks,S.L. Suppression of coupled Na-Cl absorption by aldosterone and dexamethasone in rat distal colon in vitro. Am.J.Physiol. 1984; 246(--):F785-F793. >>> Aldosterone; Dexamethasone phosphate; DMSO; Water; IP; rat; 2001; 4-7 days; comparison of agents effects; mp produces greater effect than acute admin. used in a previous study p.F791.

P0477 Higashihara,E., Carter,N.W., Pucacco,L., Kokko,J.P. Aldosterone effects on papillary collecting duct pH profile of the rat. Am.J.Physiol. 1984; 246(--):F725-F731. >>> Aldosterone; Dexamethasone; SC; rat; 2001; no duration posted; comparison of acute iv steroid injec vs. mp infusion; replacement therapy (adrenalectomy); iv continuous infusion of HCl - probably not by mp.

P0449 Dunlap,N.E., Grizzle,W.E. Golden syrian hamsters: a new experimental model for adrenal compensatory hypertrophy. Endocrinology 1984; 114(-5-):1490-1495. >>> ACTH(1-24); Aldosterone; Dexamethasone; Propylene glycol; Saline; IP; hamster; 3 days; comparison of daily im injec of Dex. vs mp infusion; comparison of agents effects; replacement therapy (adrenalectomy&hypophysect.); agents given alone&in combination; stability of ACTH verified by assay; peptides.

P0446 Grizzle,W.E., Dunlap,N.E. Aldosterone blocks adrenal compensatory hypertrophy in the rat. Am.J.Physiol. 1984; 246(--):E306-E310. >>> ACTH(1-24); Aldosterone; Dexamethasone; Propylene glycol; Saline; IP; rat; 3 days; comparison of im Dexam. injec vs. mp infusion; comparison of agents effects; replacement therapy (adrenalectomy&hypophysec.); stability of ACTH in mp verified; hormones given alone&in combination; states pumping rate was low; peptides.

P0392 Cavalieri,R.R., Castle,J.N., McMahon,F.A. Effects of dexamethasone on kinetics and distribution of triiodothyronine in the rat. Endocrinology 1984; 114(-1-):215-221. >>> Dexamethasone; Radio-isotopes; Thyroxine, l-; Triiodothyronine; 125I tracer; Albumin, human serum; Sodium hydroxide; Saline; IP; SC; rat; 2001; 2002; 5, 6, and 12 days; comparison of agents effects; replacement therapy (thyroidectomy); no stress - see p. 220; T3 and T4 used w/ and w/o 125I tracer; T4 used in 2002 pump sc, T3 in 2001 sc, Dex. in 2001 ip or sc; 3 pumps/animal.

P0377 Jackson,B.A., Braun-Werness,J.L., Kusano,E., Dousa,T.P. Concentrating defect in the adrenalectomized rat. Abnormal vasopressin-sensitive cyclic adenosine monphosphate metabolism in the papillary collecting duct. J.Clin.Invest. 1983; 72(-3-):997-1004. >>> Dexamethasone; Saline; IP; rat; 8 days; replacement therapy (adrenalectomy).

P0352 Cuthbert,A.W., Spayne,J.A. Conversion of sodium channels to a form sensitive to cyclic AMP by componemt(s) from red cells. Br.J.Pharmacol. 1983; 79(--):783-797. >>> Dexamethasone; SC; rat; 2001; 1 week; comparison of i.p. injec. vs. mp infusion.

P0227 Bia,M.J., Tyler,K.A., DeFronzo,R.A. Regulation of extrarenal potassium homeostasis by adrenal hormones in rats. Am.J.Physiol. 1982; 242(--):F641-F644. >>> Aldosterone; Dexamethasone; Ethanol; Saline; SC; rat; 7 days; organ replacement therapy (adrenalectomy).

P0186 Mostello,D.J., Hamosh,M., Hamosh,P. Effect of dexamethasone on lipoprotein lipase activity of fetal rat lung. Biol.Neonate 1981; 40(--):121-128. >>> Dexamethasone; SC; rat; 2-7 days; no comment posted.

P0061 Will,P.C., Cortright,R.N., Hopfer,U. Polyethylene glycols as solvents in implantable osmotic pumps. J.Pharm.Sci. 1980; 69(-6-):747-749. >>> Aldosterone; Corticosterone; Deoxycorticosterone acetate; Dexamethasone acetate; Estradiol, 17B-; Hydrocortisone; Progesterone; Spironolactone; Testosterone; PEG; PEG 400; PEG 600; IP; rat; 1701; no duration posted; 3-7 days aldosterone, 6 days PEG only; replacement therapy (adrenalectomy).