References on the Administration of Dexamethasone Using ALZET® Osmotic Pumps

15971 Latres, E., Pangilinan, J., Miloscio, L., Bauerlein, R., Na, E., Potocky, T. B., Huang, Y., Eckersdorff, M., Rafique, A., Mastaitis, J., Lin, C., Murphy, A. J., Yancopoulos, G. D., Gromada, J., Stitt, T. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skelet Muscle 2015; 5(--):1-13. >>> Dexamethasone; Saline; SC; Mice; Controls received mp w/ saline; animal info (male, C57BL6, 11 weeks old); Dose (23 ug/day); dose-response (pg. 9).

15775 H. JIA,, F. FRANCOIS,, J. BOURIEN,, M. EYBALIN,, R. V. LLOYD, T. R. VAN DE WATER,, J.-L. PUEL, F. VENAIL  neuroscience 2016; 316(--):261-278. >>> Dexamethasone; Ara-C; Perilymph, artificial; Ear (cochlea); Rat; 2001; Controls received mp w/ vehicle; animal info (Wistar, adult); animal info (Wistar, adult); stability verified by (incubation in 37C saline for 7 days see pg 268); one cochlea received vehicle only, while other recieved drug;.

15142 Williams, B.A., Butt, M.T., Zeller, J.R., Coffee, S., Pippi, M.A., Williams, B.A. Multimodal Perineural Analgesia with Combined Bupivacaine-Clonidine-Buprenorphine-Dexamethasone: Safe In Vivo and Chemically Compatible in Solution. PAIN MEDICINE 2015; 16(--):186-198. >>> Bupivacaine; clonidine; dexamethasone; Saline; CSF/CNS (sciatic nerve); Rat; 2ML1; Controls received mp w/ vehicle; animal info (male, albino, CD[SD]); no stress (see pg. 192); post op. care (IM butorphanol tartrate 0.05 mg/kg, ceftiofur sodium 5 mg/kg); stability verified by (pg. 195); used polyurethane catheter 0.5mm ID 0.9 mmOD; pumps removed after 1 week; dose (66.6 ug/mL).

14902 Cuffe, J.S.M., Steane, S., Moritz, K.M., Paravicini, T.M., Paravicini, T.M. Differential mRNA Expression and Glucocorticoid-Mediated Regulation of TRPM6 and TRPM7 in the Heart and Kidney throughout Murine Pregnancy and Development. PLoS One 2015; 10(--):U1394-U1410. >>> Dexamethasone sodium phosphate; corticosterone; Saline; SC; Mice (pregnant); 1003D; Controls received mp w/ saline; animal info (female, E12.5, C57Bl6J, 8-10 weeks old); teratology; cardiovascular;.

14334 Overby, D.R., Bertrand, J., Tektas, O.Y., Boussommier-Calleja, A., Schicht, M., Ethier, C.R., Woodward, D.F., Stamer, W.D., Luetjen-Drecoll, E., Overby, D.R. Ultrastructural Changes Associated With Dexamethasone-Induced Ocular Hypertension in Mice. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2014; 55(--):4922-4933. >>> Dexamethasone; Cyclodextrin; PBS; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 10-14 weeks); functionality of mp verified by serum plasma levels; post op. care (carpofen or buprenorphine given 12 hours after surgery); solutions were sterile-filtered using 0.22-um inline syringe filter; used Tissue Bond glue to close incision;.

14286 Malkoc, G., Dalgic, A., Koc, M., Kandogan, T., Korkmaz, S., Ceylan, M.E., Inan, S., Olgun, L., Dalgic, A. Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study. Journal of Laryngology and Otology 2014; 128(--):702-708. >>> Dexamethasone; Saline; Ear (round window); Rat; Controls received mp w/ vehicle; animal info (female, Albino, 250-33g, adult); used ALZET IT catheter to cannulate round window;"Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone"pg 702;.

14251 Kwiecien, J.M., Jarosz, B., Urdzikova, L.M., Rola, R., Dabrowski, W., Kwiecien, J.M. Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model. FOLIA NEUROPATHOLOGICA 2015; 53(--):41-51. >>> Dexamethasone; PBS; CSF/CNS (intrathecal); Rat; 2ML2; Controls received mp w/ vehicle; animal info (Long Evans); spinal cord injury; post op. care (ketoprofen 0.3 ml of 10 mg/ml injection, saline administration 1-2 times daily); behavioral testing (Open field testing);"Subdural infusion of dexamethasone, a powerfully anti-inflammatory, stable, synthetic analogue of glucocorticoids, allowed for circumvention of the blood-brain barrier and apparently for achieving a sufficiently high concentration of this drug in the cerebrospinal fluid in proximity of the crush lesion to prevent severe, phagocyte-rich inflammation."pg 48; used rat IT catheter; dose: 2 mg/ml.

13968 Terada, K., Izumo, N., Suzuki, B., Karube, Y., Morikawa, T., Ishibashi, Y., Kameyama, T., Chiba, K., Sasaki, N., Iwata, K., Matsuzaki, H., Manabe, T., Izumo, N. Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades. NEUROCHEMISTRY INTERNATIONAL 2014; 69(--):9-13. >>> Dexamethasone; Saline; SC; Mice; Controls received mp w/ vehicle; behavioral testing (spontaneous locomotor activity; forced swim test);"our chronic infusion model captures aspects of chronic stress loads and reduces experimental error"pg 11; depression animal model; 0.5 mg/kg/day.

13959 Somm, E., Larvaron, P., de Looij, Y.V., Toulotte, A., Chatagner, A., Faure, M., Metairon, S., Mansourian, R., Raymond, F., Gruetter, R., Wang, B., Sizonenko, S.V., Hueppi, P.S. Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism. PEDIATRIC RESEARCH 2014; 75(-1-):51-61. >>> Dexamethasone; SC; Rat (pregnant); Controls received mp w/ vehicle; animal info (female, Sprague Dawley OFA, gestational day 14); teratology; pumps used to induce intrauterine growth restriction; dose: 100 ug/kg/day.

13887 O'Connell, B.A., Moritz, K.M., Walker, D.W., Dickinson, H. Treatment of pregnant spiny mice at mid gestation with a synthetic glucocorticoid has sex-dependent effects on placental glycogen stores. PLACENTA 2013; 34(-10-):932-940. >>> Dexamethasone; Saline; SC; Mice (pregnant); 1003D; Controls received mp w/ vehicle; animal info (female, spiny mouse, day 20 gestation); teratology; pumps removed after 72 hours;.

13801 Hatano, R., Mukouchi, H., Matsumoto, Y., Kawaguchi, K., Kazama, I., Endo, Y., Toyama, H., Ejima, Y., Kurosawa, S., Kanai, Y., Matsubara, M., Asano, S., Hatano, R. Glucocorticoid mediates the transcription of OAT-PG, a kidney-specific prostaglandin transporter. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2014; 466(--):925-935. >>> Dexamethasone; SC; Rat; 2002; Controls received mp w/ saline; animal info (Sprague Dawley Rats, 180-250g); replacement therapy (adrenalectomy);.

13739 Chimin, P., Farias, T.D.M., Torres-Leal, F.L., Bolsoni-Lopes, A., Campana, A.B., Andreotti, S., Lima, F.B., Lima, F.B. Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats. ACTA PHYSIOLOGICA 2014; 211(--):409-420. >>> Dexamethasone; Saline; SC; Rat; 1004; Controls received mp w/ vehicle; animal info (male, Wistar, 10 weeks old); diabetes;.

13436 Thompson, E.M., Pishko, G.L., Muldoon, L.L., Neuwelt, E.A. Inhibition of SUR1 Decreases the Vascular Permeability of Cerebral Metastases. NEOPLASIA 2013; 15(-5-):535-543. >>> Glyburide; dexamethasone; DMSO; saline; SC; Rat (nude); 2002; Controls received mp w/ vehicle; animal info (rnu/rnu); cancer (brain tumor/metastases); Glyburide aka glibenclamide;.

13106 Platania, C.B.M., Leggio, G.M., Drago, F., Salomone, S., Bucolo, C. Regulation of intraocular pressure in mice: Structural analysis of dopaminergic and serotonergic systems in response to cabergoline. Biochemical Pharmacology 2013; 86(-9-):1347-1356. >>> Dexamethasone; Cyclodextrin; PBS; SC; Mice; 1004; Control animals received mp w/ vehicle; animal info (C57BL/6 D3R -/-, male, 8-12 wks old).

13043 Proserpio, V., Fittipaldi, R., Ryall, J.G., Sartorelli, V., Caretti, G. The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. GENES&DEVELOPMENT 2013; 27(-11-):1299-1312. >>> Dexamethasone; SC; Mice; 2002; Control animals received mp w/ saline; animal info (C57BL/6, male, 8-10 wks old).

12934 Somm, E., Vauthay, D.M., Guerardel, A., Toulotte, A., Cettour-Rose, P., Klee, P., Meda, P., Aubert, M.L., Hueppi, P.S., Schwitzgebel, V.M. Early Metabolic Defects in Dexamethasone-Exposed and Undernourished Intrauterine Growth Restricted Rats. PLoS One 2012; 7(-11-):U933-U943. >>> Dexamethasone; Rat; Animal info (Sprague Dawley, OFA, male, female, 275-350 g);.

12831 O'Connell, B.A., Moritz, K.M., Walker, D.W., Dickinson, H. Synthetic Glucocorticoid Dexamethasone Inhibits Branching Morphogenesis in the Spiny Mouse Placenta. Biology of Reproduction 2013; 88(-1-):U241-U248. >>> Dexamethasone; SC; Mice (pregnant); 1003D; Control animals received mp w/ saline; animal info (A. Cahirinus).

12699 Carrasco, D.I., Bichler, E.K., Rich, M.M., Wang, X.Y., Seburn, K.L., Pinter, M.J. Motor terminal degeneration unaffected by activity changes in SOD1(G93A) mice; a possible role for glycolysis. NEUROBIOLOGY OF DISEASE 2012; 48(-1-):132-140. >>> Tetrodotoxin; dexamethasone; CSF/CNS (sciatic nerve); Mice; 2002; Animal info (SOD1 G93A); good methods, pg 133.

12420 Veyrat-Durebex, C., Deblon, N., Caillon, A., Andrew, R., Altirriba, J., Odermatt, A., Rohner-Jeanrenaud, F. Central Glucocorticoid Administration Promotes Weight Gain and Increased 11 beta-Hydroxysteroid Dehydrogenase Type 1 Expression in White Adipose Tissue. PLoS One 2012; 7(-3-):U954-U965. >>> Dexamethasone; NaCl; CSF/CNS; Rat; 2001; 1003D; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 200-225 g, Wistar, male, 200-225 g); PE tubing used.

12350 Bas, E., Van de Water, T.R., Gupta, C., Dinh, J., Vu, L., Martinez-Soriano, F., Lainez, J.M., Marco, J. Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses. British Journal of Pharmacology 2012; 166(-6-):1888-1904. >>> Gentamicin; dexamethasone; melatonin; Ear (round window); Rat; 2001; Controls received mp w/ saline; animal info (Wistar, male, 220-250 g); stability verified after 7 days (data not shown).

12333 De Meyer, I., Martinet, W., Schrijvers, D.M., Timmermans, J.P., Bult, H., De Meyer, G.R.Y. Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques. Basic Research In Cardiology 2012; 107(-3-):U36-U48. >>> Dexamethasone; imiquimod; IA (carotid); Rabbit; 2ML1; Animal info (male, New Zeland, white, 2.5-4.0 kg); one group contained mixture of dexamethasone and imiquimod.

12113 Hu, S.I., Katz, M., Chin, S., Qi, X.Q., Cruz, J., Ibebunjo, C., Zhao, S.C., Chen, A., Glass, D.J. MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine-Rich Protein Kinase in Skeletal Muscle. Science Signaling 2012; 5(-211-):U22-U30. >>> Dexamethasone sodium phosphate; Mice; Animal info (MNK1, MNK2, MNK1/2 KO).


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“In preliminary studies using this model, we observed severe side effects with 5-FU doses beyond 25 mg/kg biweekly injections (mice developed skin ulcers, bleeding and severe diarrhea). Thus, we chose to deliver 5-FU by continuous infusion at an equivalent cumulative dose in order to minimize toxicity. Additionally, studies have demonstrated an increased efficacy of chemotherapeutic agents when administered continuously.” Stoeltzing et al. Int. J. Cancer 2003;104:496-503.