References on Diabetes Research Using ALZET® Osmotic Pumps

16346 Karimi Galougahi, K., Liu, C. C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, C. L., Figtree, G. A. beta3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia. J Am Heart Assoc 2016; 5(-2-):. >>> S961; CL-316243; Saline; SC; Rabbit; 2ML1; Controls received mp w/ vehicle; animal info (male New Zealand White rabbits, 2.2– 2.6 kg); functionality of mp verified by plasma levels; Diabetes-induced vascular dysfuntcion; Hyperglycemia study; Dose (12 ug/kg/hr S961, 40 ug/kg/hr CL);.

16298 Jeremie Boucher,, Samir Softic,, Abdelfattah El Ouaamari,, Megan T. Krumpoch,, Andre Kleinridders,, Rohit N. Kulkarni,, Brian T. O’Neill,, C. Ronald Kahn1  Diabetes 2016; 66(--):2201-2213. >>> Leptin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (Fat-specific IR, IGF1R, and IR/IGF1R knockout mice; 3 month old); functionality of mp verified by blood glucose levels; dose-response (pg 2204-2206); behavioral testing (cold-resistance testing); replacement therapy (leptin); Lipoatrophic diabetes; Dose (10 ug/mouse/d);.

16286 Denroche, H. C., Glavas, M. M., Tuduri, E., Karunakaran, S., Quong, W. L., Philippe, M., Britton, H. M., Clee, S. M., Kieffer, T. J. Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity. Endocrinology 2016; 157(-7-):2671-85. >>> Leptin, recombinant mouse; SC; mice; 1007D, 1002; Controls received mp w/ vehicle; animal info (Male Leprflox/flox and Leprflox/flox Syn-cre mice, 12-14 wks); functionality of mp verified by plasma levels; pumps replaced after day 10; dose-response (pg. 2679); diabetes; Dose (10 ug/d or 20 ug/d);.

16279 Youn, J. Y., Zhou, J., Cai, H. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol 2015; 29(-8-):1123-33. >>> Noggin; NaCl, Acetic Acid; SC; Mice; Controls received mp w/ vehicle; animal info (Male BKS.Cgm-/- Leprdb/J (db/db) diabetic mice); functionality of mp verified by plasma levels; diabetes; Resultant plasma level (pg. 1125); Resultant plasma level (pg. 1125);.

16238 Aiko Sakamoto,, Yasutomi Higashikuni,, Makiko Hongo,, Yasushi Imai,, Kazuhiko Koike,, Ryozo Nagai,, Issei Komuro,, Nobukazu Ishizaka  Journal of Atherosclerosis and Thrombosis 2015; 22(-12-):1225-1234. >>> Angiotensin II (Val5); SC; rat; Controls received no treatment; animal info (male Sprague-Dawley rats, 250-300 g); dose-response (pg 1228); diabetes; Dose (0.7 mg/kg/day);.

16219 Keunhee Oh,, Sae Rom Kim,, Dae-Kyum Kim,, Myung Won Seo,, Changjin Lee,, Hak Mo Lee,, Ju-Eun Oh,, Eun Young Choi,, Dong-Sup Lee,, Yong Song Gho,, Kyong Soo Park  ACS Nano 2015; 9(-12-):11718-11727. >>> Insulin; SC; Mice (NOD); animal info (BALB/c, NOD male mice, aged 7-10 wks); functionality of mp verified by blood glucose levels; diabetes; Dose (0.14 units/day);.

16206 Maeda, S., Matsui, T., Ojima, A., Suematsu, M., Kaseda, K., Higashimoto, Y., Yamakawa, R., Yamagishi, S. DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy. Ophthalmic Res 2015; 54(-4-):175-80. >>> AGE-aptamer; BSA; IP; rat; 1004; Controls received mp w/ control aptamer; animal info (Six-week-old male Wistar rats); functionality of mp verified by urine tests; pumps replaced every 4 weeks; antisense (AGE-aptamer versus control aptamer); diabetes; AGE-aptamer aka Advanced Glycation End Products Aptamer; Dose (6 ng/body weight/day);.

16187 Talton, O. O., Pennington, K. A., Pollock, K. E., Bates, K., Ma, L., Ellersieck, M. R., Schulz, L. C. Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice. Endocrinology 2016; 157(-7-):2636-48. >>> Leptin; Saline; SC; Mice (pregnant); 2004; Controls received mp w/ vehicle; animal info (female, WT); stress/adverse reaction: (see pg. 2645); teratology; diabetes; Dose (350 ng/h);.

16172 Schaschkow, A., Mura, C., Dal, S., Langlois, A., Seyfritz, E., Sookhareea, C., Bietiger, W., Peronet, C., Jeandidier, N., Pinget, M., Sigrist, S., Maillard, E. Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model. J Diabetes Res 2016; 2016(--):8310516. >>> insulin; buffer solution; SC; rat; animal info (male, Lewis, STZ injection); comparison of injection of insulin vs mp; post op. care (Baytril 10 mg/kg QD for 7 days); diabetes; pumps primed for 24 hours in 37C saline;“…continuous insulin delivery by pumps restored normoglycaemia, which induced the reduction of both reactive oxygen species and macrophage infiltration into the liver and omentum. Injections controlled the glucose levels for only a short period of time and therefore tissue stress and inflammation were elevated.” pg 1; “pumps require no daily injection and facilitate rat follow- up. Well-being of the animals and the homogeneity of the results permit researchers to limit the numbers of animals and experiments used to build solid and reproducible results.” pg 8; Dose (4 IU/day);.

16150 Pang, Y., Li, Y., Lv, Y., Sun, L., Zhang, S., Li, Y., Wang, Y., Liu, G., Xu, M. J., Wang, X., Jiang, C. Intermedin Restores Hyperhomocysteinemia-induced Macrophage Polarization and Improves Insulin Resistance in Mice. J Biol Chem 2016; 291(-23-):12336-45. >>> Intermedin; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 6 weeks old); immunology; peptides; diabetes; Dose (318 ng/kg/h);.

16146 Okizaki, S., Ito, Y., Hosono, K., Oba, K., Ohkubo, H., Kojo, K., Nishizawa, N., Shibuya, M., Shichiri, M., Majima, M. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1beta by Recruited Macrophages. Am J Pathol 2016; 186(-6-):1481-98. >>> Placenta growth factor, recombinant human; antibody, interleukin-1B; PBS; SC; Mice; 1007D; Controls received mp w/ vehicle or control antibody; animal info (male, C57BL6, 8 weeks old, STZ); immunology; diabetes; Dose (PlGF 10 ug/mouse; anti-IL-1B 1 ug/day);.

16095 Danny Ben-Zvi, Ornella Barrandon, Stephanie Hadley, Barak Blum, Quinn P. Peterson, and Douglas A. Melton  PNAS 2015; 112(-50-):15498-15503. >>> Glucagon, des-His1-Glu9 (1-29); Angptl4, recombinant human; Angptl4, mouse; Angptl3, human; PBS; BSA; SC; mice; 1003D; 2001; Controls received mp w/ vehicle; C57BL/6 served as controls; animal info: C57BL/6, Angptl4−/− mice, 8 weeks; functionality of mp verified by glucose and glucagon levels; diabetes; Glucagon, des-His1-Glu9 (1-29) -- glucagon receptor antagonist; Dose: 1 mg glucagon receptor antagonist; 10 ug of each type of Angptl;.

16091 Alejandro, E. U., Bozadjieva, N., Kumusoglu, D., Abdulhamid, S., Levine, H., Haataja, L., Vadrevu, S., Satin, L. S., Arvan, P., Bernal-Mizrachi, E. Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and beta Cell Failure. Cell Rep 2015; 13(-11-):2527-38. >>> Phloridzin; SC; mice; 2006; animal info: bOGT-/- (70 day old, 25 g; 50 day old, 20.5 g); diabetes; Hyperglycemia; glucose tolerance; specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2); Dose: dose of 0.8 mg/kg/day (_5 mg/ml).

16081 Song-Yang Zhang,, Ying Lv,, Heng Zhang,, Song Gao,, Ting Wang,, Juan Feng,, Yuhui Wang,, George Liu,, Ming-Jiang Xu,, Xian Wang,, Changtao Jiang  Diabetes 2016; 65(--):2342-2355. >>> Adrenomedullin 2; Saline; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (WT or aADM2-tg); peptides; diabetes; Dose (3000 ng/kg/hr); Resultant plasma level (see supplement pg 8, figure 7E);.

16079 Zhang, H., Zhang, S. Y., Jiang, C., Li, Y., Xu, G., Xu, M. J., Wang, X. Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice. Int J Obes (Lond) 2016; 40(-5-):852-60. >>> Adrenomedullin 2; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-10 weeks old); peptides; diabetes; Dose (300 ng/kg/hr); obesity.

16071 Xu, H. Z., Cheng, Y. L., Wang, W. N., Wu, H., Zhang, Y. Y., Zang, C. S., Xu, Z. G. 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance. Int J Mol Sci 2016; 17(-5-):. >>> Hydroxyeicosatetraenoic acid, 12(S)-; Saline, normal; SC; Rat; 1002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 180-200g); cardiovascular; diabetes; bp measured using tail cuff; Dose (1 mg/kg/day);.

16061 Wang, S., Wang, L., Dou, L., Guo, J., Fang, W., Li, M., Meng, X., Man, Y., Shen, T., Huang, X., Li, J. MicroRNA 152 regulates hepatic glycogenesis by targeting PTEN. FEBS J 2016; 283(-10-):1935-46. >>> Interleukin-6; Mice; animal info (male, C57Bl6J, 12 weeks old); diabetes;.

16003 Plato Mak,, Jillian H. Broadbear,, Anton Kolosov,, Colin S. Goodchild,  PAIN MEDICINE 2015; 16(--):1781-1793. >>> Ketamine; morphine; SC; Rat; 2ML1; Controls received dummy implant; animal info (male, Wistar); post op. care (carpofen IP injection); behavioral testing (nociception, rotarod, open field); diabetes; pumps removed after 5 days; Dose (20 mg/kg/day);.

15933 Murase, H., Kuno, A., Miki, T., Tanno, M., Yano, T., Kouzu, H., Ishikawa, S., Tobisawa, T., Ogasawara, M., Nishizawa, K., Miura, T. Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. Cardiovasc Diabetol 2015; 14(--):103. >>> Vildagliptin; exenatide; chloroquine; Saline; Mice; Controls received mp w/ vehicle; animal info (male, LETO or OLETF, 25-30 weeks old); cardiovascular; diabetes;“The pharmacological agents were administered via osmotic minipumps, not via drinking water containing the agents, because the amount of water rats drink per day is not consistent.” pg 2; enzyme inhibitor (Dipeptidyl peptidase-4, DPP-4); Dose (chloroquine 10 mg/kg/day; Vildagliptin 10 mg/kg/day;Exenatide 10 ug/kg/day);.

15899 Yi, P., Park, J. S., Melton, D. A. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 2013; 153(-4-):747-58. >>> S961; PBS; SC; mice; 2001; peptides; C57BL/6J mice; dose-response Fig. 1; mp were used to infuse S961 to cause hyperglycemia. S961makes mice glucose intolerant, and blocks the insulin receptor; insulin receptor antagonist; beta cell replication, increase in beta cell mass; diabetes therapy; dose: 2.5-10 nmol;.

15890 Tiyerili, V., Becher, U. M., Camara, B., Yildirimturk, C., Aksoy, A., Kebschull, M., Werner, N., Nickenig, G., Muller, C. Impact of peroxisome proliferator-activated receptor gamma on angiotensin II type 1 receptor-mediated insulin sensitivity, vascular inflammation and atherogenesis in hypercholesterolemic mice. Arch Med Sci 2015; 11(-4-):877-85. >>> GW9662; SC; mice; Controls received mp w/ vehicle; animal info (female, ApoE -/-/AT1R -/-, 6 weeks old); cardiovascular; diabetes; Dose (700 ng/kg/min);.

15885 Shao, C., Yu, L., Gao, L. Activation of angiotensin type 2 receptors partially ameliorates streptozotocin-induced diabetes in male rats by islet protection. Endocrinology 2014; 155(-3-):793-804. >>> Compound 21; SC; rat; Controls received mp w/ saline; animal info (male, Sprague Dawley, 280-320g); cardiovascular; diabetes; Dose (0.25, 0.48, 0.96 mg/kg/day);.

15880 Templeman, N. M., Clee, S. M., Johnson, J. D. Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity. Diabetologia 2015; 58(-10-):2392-402. >>> Insulin2, murine peptide; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (Ins1 -/-; 25 weeks old); functionality of mp verified by plasma insulin; peptides; diabetes; Dose (0.1 U/day);.

15876 Sasaki, S., Miyatsuka, T., Matsuoka, T. A., Takahara, M., Yamamoto, Y., Yasuda, T., Kaneto, H., Fujitani, Y., German, M. S., Akiyama, H., Watada, H., Shimomura, I. Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia 2015; 58(-11-):2582-91. >>> Exendin 9-39; Mice; 2002; animal info (NEUROG3-Timer, Sox9-CreER and ROSA26 lacZ reporter); diabetes; Dose (150 pmol/kg/min);.

15859 Mingfeng Zhang, Qing Lina,, Tong Qi, Tiankun Wang, Ching-Cheng Chen, Arthur D. Riggsa,, Defu Zeng  pnas 2016; 113(-3-):650-655. >>> Gastrin; epidermal growth factor, human recombinant; Acetic acid; PBS; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, WT or Ins1 CreERT); diabetes; Dose (gastrin 3 ug/kg/hr; EGF 10 ug/kg/hr);.

15805 Oleg Otlivanchik, Nicole M. Sanders, Ambrose Dunn-Meynell,, Barry E. Levin  am J Physiol Regul Integr Comp Physiol 2016; 310(--):R66-R73. >>> Sertraline; Ethanol; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 7-8 weeks old, 250-400g); 50% ethanol used; behavioral testing (open field); diabetes; Dose (7.5 mg/kg/day);.

15804 Mark K. Nøhr, Anete Dudele, Morten M. Poulsen, Lene H. Ebbesen, Yulia Radko, Lars P. Christensen, Niels Jessen, Bjørn Richelsen, Sten Lund, Steen B. Pedersen  PLoS One 2016; 11(-1-):1-15. >>> Endotoxin, LPS; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL/6N, 12 weeks old); immunology; diabetes; Dose (600 ug/kg/day);.

15774 Colin M. Hyslop,, Sue Tsai,, Vipul Shrivastava,, Pere Santamaria,, Carol Huang  Endocrinology 2016; 157(-1-):150-165. >>> Prolactin, recombinant mouse; Albumin, mouse; Mice (NOD); 1004; Controls received mp w/ vehicle; Controls received mp w/ vehicle; diabetes; Therapeutic indication (diabetes); Dose (2.7 ug/d); resulted in serum PRL level 300-500 ng/mL;.

15754 Stephanie Dal,, Nathalie Jeandidier,, Elodie Seyfritz,, William Bietiger,, Claude Pe´ronet,, Franc¸ois Moreau,, Michel Pinget,, Elisa Maillard, and Se´verine Sigrist  EXPERIMENTAL BIOLOGY AND MEDICINE 2016; 241(--):184-192. >>> Insulin; SC; Rats; 2006; animal info (male, Wistar, 180-200g, STZ); immunology; diabetes;"The intensive subcutaneous insulin administrationperformed using a mini pump in our study led to animprovement in the metabolic control of diabetic rats, as confirmed by a decrease in fructosamine levels and an increase in body weight after four weeks of treatment. Moreover, blood insulin concentration was maintained at the same level throughout the study attesting to the efficiency of this therapy."pg 189; Dose (2 UI/200g/day);.

15214 Hartner, A., Cordasic, N., Klanke, B., Menendez-Castro, C., Veelken, R., Schmieder, R.E., Hilgers, K.F. Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stress. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014; 1842(-4-):558-565. >>> Irbesartan; IP; Rat; 2004; Animal info (male, Sprague Dawley, 12 weeks old, STZ); cardiovascular; diabetes; bp measured using tail cuff;.

15179 Zhao, J.Z., Liu, C.Q., Bai, Y.T., Wang, T.Y., Kan, H.D., Sun, Q.H., Sun, Q.H. IKK inhibition prevents PM(2.5)-exacerbated cardiac injury in mice with type 2 diabetes. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 2015; 31(--):98-103. >>> IMD-0354; DMSO; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (KKay, 7 weeks old); long-term study; cardiovascular; immunology; diabetes; used Plastics One Cannula;.

15177 Zhang, Y.Y., Fang, F., Goldstein, J.L., Brown, M.S., Zhao, T.J., Goldstein, J.L. Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):1226-1231. >>> Ghrelin, recombinant rat; Sodium bicarbonate; NaCl; albumin, rat; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, Goat -/-, 8 weeks old); diabetes; obesity;.

15176 Zhang, Y.Y., Guo, Q.Y., Wu, M.Y., Zang, C.S., Ma, F.Z., Sun, T., Wang, W.N., Miao, L.N., Xu, Z.G., Xu, Z.G. p16(ink4a) Expression Is Increased through 12-Lipoxygenase in High Glucose-Stimulated Glomerular Mesangial Cells and Type 2 Diabetic Glomeruli. NEPHRON 2015; 130(--):141-150. >>> Hydroxyeicosatetraenoic acid, 12(s)-; Saline; SC; Rat; 1002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley); diabetes; Hydroxyeicosatetraenoic acid, 12(s)- aka HETE, 12S-;.

15249 pelletYu, Z., Tang, L., Chen, L.F., Li, J.F., Wu, W.F., Hu, C.L., Tang, L. Role for HIF-1alpha and Downstream Pathways in Regulating Neuronal Injury after Intracerebral Hemorrhage in Diabetes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015; 37(--):67-76. >>> Estradiol, 2-methoxy; ML228; CSF, artificial; Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-300g, STZ); ALZET brain infusion kit used; diabetes;“This intervention allowed animals to receive continuous intracerebroventricular (ICV) infusion via the minipumps before brain tissues were removed. ” pg 69;.

15151 Yang, H.J., Kwon, D.Y., Kim, M.J., Kang, S., Moon, N.R., Daily, J.W., Park, S., Park, S. Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. Nutrition&Metabolism 2015; 12(--):U15-U26. >>> Amyloid protein, beta (25-35); CSF/CNS (hippocampus); Rat; Controls received mp w/ scrambled amyloid protein; animal info (male, Sprague Dawley, 192 +/-30g, ); neurodegenerative (Alzheimer's disease); behavioral testing (locomotive activity, passive avoidance, Morris water maze); tissue perfusion (CA1 subregion of hippocampus); diabetes;.

15256 Wu, Y., Song, P., Zhang, W.C., Liu, J.H., Dai, X.Y., Liu, Z.Y., Lu, Q.L., Ouyang, C.H., Xie, Z.L., Zhao, Z.X., Zhuo, X.Z., Viollet, B., Foretz, M., Wu, J.L., Yuan, Z.Y., Zou, M.H., Zou, M.H. Activation of AMPKalpha2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. NATURE MEDICINE 2015; 21(--):373-+. >>> Nicotine; Saline; SC; Mice; rat; Controls received mp w/ vehicle; animal info (mice male, C57BL6J, 8 weeks old; rat male, Sprague Dawley, 10 weeks old); diabetes; long-term study;.

15131 Wang, M.Y., Yan, H., Shi, Z.Q., Evans, M.R., Yu, X.X., Lee, Y., Chen, S., Williams, A., Philippe, J., Roth, M.G., Unger, R.H., Roth, M.G. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):2503-2508. >>> Leptin, recombinant; pramlintide acetate; liraglutide; exenatide; SC; Mice (NOD); 2001; Controls received mp w/ PBS; animal info (female, NOD/ShiLtJ, 8 weeks old); pumps replaced every 7 days; long-term study; diabetes;.

15253 Vu, B.G., Stach, C.S., Kulhankova, K., Salgado-Pabon, W., Klingelhutz, A.J., Schlievert, P.M., Schlievert, P.M. Chronic Superantigen Exposure Induces Systemic Inflammation, Elevated Bloodstream Endotoxin, and Abnormal Glucose Tolerance in Rabbits: Possible Role in Diabetes. MBIO 2015; 6(--):U999-U1008. >>> Toxic shock syndrome toxin-1; SC; Rabbit; 2006; Controls received mp w/ PBS; animal info (New Zealand White); immunology; diabetes; Toxic shock syndrome toxin-1 aka TSST-1; long-term study;.

15103 Taylor, S.L., Trudeau, D., Arnold, B., Wang, J.S., Gerrow, K., Summerfeldt, K., Holmes, A., Zamani, A., Brocardo, P.S., Brown, C.E., Brown, C.E. VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes. NEUROBIOLOGY OF DISEASE 2015; 78(--):1-11. >>> Vascular endothelial growth factor (165); CSF, artificial; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, C57BL6J, 2 months old); ALZET brain infusion kit 3 used; behavioral testing (Morris water maze); diabetes;.

15102 Taveau, C., Chollet, C., Waeckel, L., Desposito, D., Bichet, D.G., Arthus, M.F., Magnan, C., Philippe, E., Paradis, V., Foufelle, F., Hainault, I., Enhorning, S., Velho, G., Roussel, R., Bankir, L., Melander, O., Bouby, N., Bouby, N. Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats. DIABETOLOGIA 2015; 58(--):1081-1090. >>> Vasopressin; IP; Rat; Animal info (male, Fa/fa Zucker, 7 weeks old); no stress (see pg. 1083-1084); diabetes;.

15100 Tan, C.Y.R., Weier, Q., Zhang, Y., Cox, A.J., Kelly, D.J., Langham, R.G., Langham, R.G. Thioredoxin-Interacting Protein: A Potential Therapeutic Target for Treatment of Progressive Fibrosis in Diabetic Nephropathy. NEPHRON 2015; 129(--):109-127. >>> Thioredoxin-interacting protein DNAzyme; SC; Rat; 2006; Controls received mp w/ scrambled TXNIP DNAzyme; animal info (female, heterozygous (mRen-2)27, 6 weeks old); pumps replaced every 6 weeks; cardiovascular; diabetes; Thioredoxin-interacting protein aka TXNIP;.

15062 Plante, E., Menaouar, A., Danalache, B.A., Yip, D., Broderick, T.L., Chiasson, J.L., Jankowski, M., Gutkowska, J., Gutkowska, J. Oxytocin Treatment Prevents the Cardiomyopathy Observed in Obese Diabetic Male db/db Mice. ENDOCRINOLOGY 2015; 156(--):1416-1428. >>> Oxytocin; NaCl; BSA; sodium citrate; SC; Mice; 2006; Controls received mp w/ vehicle; animal info (C57BL/KsJ-leptdb-leptdb); functionality of mp verified by plasma levels; pumps replaced every 6 weeks; long-term study; diabetes;“After 6 weeks, the osmotic pumps were replaced to adjust the OT concentration for body weight gain.” pg 1417;.

15057 Persson, P., Friederich-Persson, M., Fasching, A., Hansell, P., Inagi, R., Palm, F., Persson, P. Adenosine A(2)a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress. Acta Physiologica 2015; 214(--):311-318. >>> CGS21680; DMSO; Ringer's solution; SC; Rat; 2004; Animal info (male, Sprague Dawley, 250-g, STZ); post op. care (carpofen 5 mg/kg SC); cardiovascular; immunology; antihypertensive; diabetes; CGS21680 is an A2aAR agonist;.

15002 Lee, S.H., Moon, S.J., Paeng, J., Kang, H.Y., Nam, B.Y., Kim, S., Kim, C.H., Lee, M.J., Oh, H.J., Park, J.T., Han, S.H., Yoo, T.H., Kang, S.W., Kang, S.W. Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions. APOPTOSIS 2015; 20(--):1056-1071. >>> zAsp-DCB; SC; Rat; Animal info (male, Sprague Dawley, 250-280g, 9-10 weeks old); long-term study; diabetes; enzyme inhibitor (pan-caspase);.

14998 Kondegowda, N.G., Fenutria, R., Pollack, I.R., Orthofer, M., Garcia-Ocana, A., Penninger, J.M., Vasavada, R.C., Vasavada, R.C. Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-kappaB Ligand Pathway. Cell Metabolism 2015; 22(--):77-85. >>> Prolactin, ovine; PBS; BSA; SC; Mice; Controls received mp w/ saline; animal info (male, OPG-KO, 12-14 weeks old); diabetes;.

14985 Kariharan, T., Nanayakkara, G., Parameshwaran, K., Bagasrawala, I., Ahuja, M., bdel-Rahman, E., Amin, A.T., Dhanasekaran, M., Suppiramaniam, V., Amin, R.H., Amin, R.H. Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression. NEUROBIOLOGY OF AGING 2015; 36(--):1451-1461. >>> Rosiglitazone; Saline, sterile; CSF/CNS; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6 or db/db, 4 months old); behavioral testing (y-maze spatial memory; object recognition test); diabetes;.

14956 Hao, P.P., Yang, J.M., Zhang, M.X., Zhang, K., Chen, Y.G., Zhang, C., Zhang, Y., Zhang, Y. Angiotensin-(1-7) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H1007-H1019. >>> Angiotensin (1-7); perinodopril; A779; PD123319; NaCl; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 200g, STZ); cardiovascular; peptides; diabetes;.

14942 Gerritsen, K.G.F., Leeuwis, J., Koeners, M.P., Bakker, S.J.L., van Oeveren, W., Aten, J., Tarnow, L., Rossing, P., Wetzels, J.F.M., Joles, J.A., Kok, R.J., Goldschmeding, R., Nguyen, T.Q., Nguyen, T.Q. Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction. JOURNAL OF DIABETES RESEARCH 2015; ;(--):U1-U11. >>> CTGF, recombinant human; FITC-inulin; SC; Mice; 1003D; Controls received mp w/ vehicle; animal info (male, C57BL6, 10-12 weeks old, STZ); Multiple pumps per animal (2); cardiovascular; diabetes;.

14917 Desposito, D., Potier, L., Chollet, C., Gobeil, F.Jr, Roussel, R., henc-Gelas, F., Bouby, N., Waeckel, L., Waeckel, L. Kinin Receptor Agonism Restores Hindlimb Postischemic Neovascularization Capacity in Diabetic Mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2015; 352(--):218-226. >>> SarLys[Hyp3, Igl5, DPhe8]desArg9-bradykinin; [Hyp(3),Thi(5),(N)Chg(7),Thi(8)]-bradykinin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 10 weeks old, STZ); ischemia (femoral artery); cardiovascular; diabetes; SarLys[Hyp3, Igl5, DPhe8]desArg9-bradykinin is a selective B1R agonist; [Hyp(3),Thi(5),(N)Chg(7),Thi(8)]-bradykinin is a selective B2R agonist; bp measured using tail cuff;.

14916 Denroche, H.C., Kwon, M.M., Quong, W.L., Neumann, U.H., Kulpa, J.E., Karunakaran, S., Clee, S.M., Brownsey, R.W., Covey, S.D., Kieffer, T.J., Kieffer, T.J. Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol. DIABETOLOGIA 2015; 58(--):1100-1108. >>> Leptin, recombinant murine; Water; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-10 weeks old, STZ); functionality of mp verified by plasma levels; diabetes;.

14904 da Silva, A.A., Spradley, F.T., Granger, J.P., Hall, J.E., do Carmo, J.M., da Silva, A.A. Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling. JOURNAL OF NEUROPHYSIOLOGY 2015; 113(--):2786-2791. >>> Leptin; CSF/CNS; Rat; 2001; Animal info (male, Wistar, 14-16 weeks old, STZ); diabetes; after 7 days of infusion, ICV cannula was severed;.

14875 Chang, T.T., Wu, T.C., Huang, P.H., Lin, C.P., Chen, J.S., Lin, L.Y., Lin, S.J., Chen, J.W., Chen, J.W. Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism. PLoS One 2015; 10(--):U1637-U1653. >>> Aliskiren; olmesartan; candesartan; PBS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, FVB/NJNarl, 6 weeks old); ischemia (hind limb); diabetes; long-term study;.

14855 Burgos-Ramos, E., Canelles, S., Rodriguez, A., Gomez-Ambrosi, J., Frago, L.M., Chowen, J.A., Fruehbeck, G., Argente, J., Barrios, V., Barrios, V. Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2015; 415(--):157-172. >>> Leptin; BSA; CSF/CNS; SC; Rat; Controls received mp w/ saline; animal info (male, Wistar, adult, 250 +/-10g); 1% BSA used; diabetes;.

14850 Boparai, R.K., Arum, O., Miquet, J.G., Masternak, M.M., Bartke, A., Khardori, R.K., Arum, O. Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2015; ;(--):U1-U11. >>> Fibroblast growth factor 21, human recombinant; PBS; SC; Mice (transgenic); 1007D; Controls received mp w/ vehicle; animal info (male, transgenic overexpress bovine growth hormone, 3-4 months old); diabetes;.

14847 Bonner, C., Kerr-Conte, J., Gmyr, V., Queniat, G., Moerman, E., Thevenet, J., Beaucamps, C., Delalleau, N., Popescu, I., Malaisse, W.J., Sener, A., Deprez, B., Abderrahmani, A., Staels, B., Pattou, F., Pattou, F. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. NATURE MEDICINE 2015; 21(--):512-U139. >>> S961; PBS; Mice; 2001; Controls received mp w/ vehicle; animal info (male, C57BL6J Rat 2 -/-, 8-9 weeks old); dose-response (pg 514); diabetes;.

14844 Bernardo, B., Lu, M., Bandyopadhyay, G., Li, P.P., Zhou, Y.J., Huang, J., Levin, N., Tomas, E.M., Calle, R.A., Erion, D.M., Rolph, T.P., Brenner, M., Talukdar, S., Talukdar, S. FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. SCIENTIFIC REPORTS 2015; 5(--):U1-U13. >>> Fibroblast growth factor 21; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, DIO, 16, 21, or 32 weeks old); diabetes;.

14830 Aye, I.L.M.H., Rosario, F.J., Powell, T.L., Janssona, T., Aye, I.L.M.H. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):12858-12863. >>> Adiponectin; PBS; SC; Mice (pregnant); 1003D; Controls received mp w/ PBS; animal info (female, C57BL6J); teratology; diabetes;.

14785 Zheng, H., Pu, S.Y., Fan, X.F., Li, X.S., Zhang, Y., Yuan, J., Zhang, Y.F., Yang, J.L., Yang, J.L. Treatment with angiotensin-(1-9) alleviates the cardiomyopathy in streptozotocin-induced diabetic rats. BIOCHEMICAL PHARMACOLOGY 2015; 95(--):38-45. >>> Angiotensin (1-9); PD123319; A779; Water, distilled; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley STZ, 2 months old); cardiovascular; peptides; diabetes;.

14782 Zhou, G.Y., Liu, X., Cheung, A.K., Huang, Y.F., Zhou, G.Y. Efficacy of aliskiren, compared with angiotensin II blockade, in slowing the progression of diabetic nephropathy in db/db mice: should the combination therapy be a focus?. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 2015; 7(--):825-840. >>> Aliskiren; SC; Mice; 2004; Animal info (male, db/db, 18 or 22 weeks); cardiovascular; diabetes; bp measured using tail cuff;.

14529 Zhang, Y., Liu, J., Tian, X.Y., Wong, W.T., Chen, Y.C., Wang, L., Luo, J.Y., Cheang, W.S., Lau, C.W., Kwan, K.M., Wang, N.P., Yao, X.Q., Huang, Y., Huang, Y. Inhibition of Bone Morphogenic Protein 4 Restores Endothelial Function in db/db Diabetic Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2014; 34(--):152-+. >>> Noggin; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, db/db, 12-14 weeks old); cardiovascular; diabetes; bp measured using tail cuff;.

14516 Yu, L.M., Tu, Q.S., Han, Q.Q., Zhang, L., Sui, L., Zheng, L.L., Meng, S., Tang, Y., Xuan, D.Y., Zhang, J., Murray, D., Shen, Q.P., Cheng, J., Kim, S.H., Dong, L.Q., Valverde, P., Cao, X.M., Chen, J., Chen, J. Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway: An Approach for Treating Bone Disease in Diabetes. Stem Cells 2015; 33(--):240-252. >>> Adiponectin; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (APN -/-, C57BL6J, DIO, 14 weekd old); diabetes;.

14500 Yang, H.J., Kwon, D.Y., Kim, H.J., Kim, M.J., Jung, D.Y., Kang, H.J., Kim, D.S., Kang, S., Moon, N.R., Shin, B.K., Park, S., Park, S. Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer's type dementia. EUROPEAN JOURNAL OF NUTRITION 2015; 54(--):77-88. >>> Amyloid protein, beta (35-25); amyloid protein, beta (25-35); Saline; CSF/CNS (hippocampus); Rat; Controls received mp w/ control B-amyloid protein (25-35); animal info (male, Sprague Dawley, 223g); bilateral cannula used; neurodegenerative (alzheimer's); behavioral testing (locomotor activity, passive avoidance test, morris water maze); diabetes;.

14491 Xu, S.Q., Jiang, Y.W., Wang, H., Wang, Z., Liu, H.L., Peng, L., Fang, Q., Deng, T.T., You, J., Zhou, X.F., Zhang, W.J., Lou, J.N., Zhang, W.J. C-peptide ameliorates renal injury in type 2 diabetic rats through protein kinase A-mediated inhibition of fibronectin synthesis. Biochemical and Biophysical Research Communications 2015; 458(--):674-680. >>> C-peptide; IP; Rat; 2004; Controls received mp w/ saline, isotonic; animal info (male, GK, 8 weeks old); pumps replaced every 4 weeks; long-term study; cardiovascular; peptides; diabetes;.

14482 Wu, K.L.H., Chao, Y.M., Tsay, S.J., Chen, C.H., Chan, S.H.H., Dovinova, I., Chan, J.Y.H., Chan, J.Y.H. Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome. Hypertension 2014; 64(--):815-+. >>> Tempol; coenzyme Q10; CSF, artificial; CSF/CNS (cisterna magna); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley 8 weeks old, 235-296g); post op. care (1000 IU IM); tissue perfusion (cisterna magna); cardiovascular; diabetes; used PE-10 catheter;.

14478 White, J.T., DeSanto, C.L., Gibbons, C., Lardner, C.K., Panakos, A., Rais, S., Sharp, K., Sullivan, S.D., Tidhar, W., Wright, L., Berrigan, D., Heideman, P.D., Heideman, P.D. Insulins, leptin and feeding in a population of Peromyscus leucopus (white-footed mouse) with variable fertility. Hormones and Behavior 2014; 66(--):169-179. >>> Leptin, mouse recombinant; Saline; BSA; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (P leucopus); functionality of mp verified by serum levels; diabetes;.

14477 Weissmann, L., Quaresma, P.G.F., Santos, A.C., de Matos, A.H.B., Pascoal, V.D.B., Zanotto, T.M., Castro, G., Guadagnini, D., da Silva, J.M., Velloso, L.A., Bittencourt, J.C., Lopes-Cendes, I., Saad, M.J.A., Prada, P.O., Prada, P.O. IKKepsilon Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity. Diabetes 2014; 63(--):3334-3345. >>> RNA, small interfering; CSF/CNS; Mice; 1007D; Controls received mp w/ scrambled RNA; animal info (male, C57BL6J or db/db, 8 weeks old); diabetes; obesity; used Plastics One cannula;.

14468 Wang, Y., Roth, J.D., Taylor, S.W., Wang, Y. Simultaneous quantification of the glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) receptor agonists in rodent plasma by on-line solid phase extraction and LC-MS/MS. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2014; 957(--):24-29. >>> AC170222l; AC3174; DMSO; water; acetate buffer; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (rat male, Sprague Dawley, 4-5 weeks old; mice lep ob/lep ob, 46.3g); functionality of mp verified by plasma levels; 50% DMSO used; peptides; diabetes; AC170222 and AC3174 are peptide agonists of glucagon-like peptide-1 receptor and cholecystokinin-1 receptor;.

14434 Tatarkiewicz, K., Sablan, E.J., Polizzi, C.J., Villescaz, C., Parkes, D.G., Parkes, D.G. Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2014; 306(--):R490-R498. >>> Exenatide; DMSO; water; BSA; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, GLP-1R knockout or WT, 7-13 weeks old); functionality of mp verified by blood plasma; pumps replaced every month; 50% DMSO used; 0.1% BSA used; long-term study; diabetes;.

14427 Tamasi, V., Petschner, P., Adori, C., Kirilly, E., Ando, R.D., Tothfalusi, L., Juhasz, G., Bagdy, G., Tamasi, V. Transcriptional Evidence for the Role of Chronic Venlafaxine Treatment in Neurotrophic Signaling and Neuroplasticity Including also Glutatmatergic- and Insulin-Mediated Neuronal Processes. PLoS One 2014; 9(--):U773-U796. >>> Venlafaxine; NaCl; SC; Rat; 2001; Controls received sham surgery; animal info (male, Dark Agouti, 8 weeks old; 150g); diabetes;.

14367 te Riet, L., van den Heuvel, M., Peutz-Kootstra, C.J., van Esch, J.H.M., van Veghel, R., Garrelds, I.M., Musterd-Bhaggoe, U., Bouhuizen, A.M., Leijten, F.P.J., Danser, A.H.J., Batenburg, W.W., Batenburg, W.W. Deterioration of kidney function by the (pro)renin receptor blocker handle region peptide in aliskiren-treated diabetic transgenic (mRen2)27 rats. American Journal of Physiology-Renal Physiology 2014; 306(--):F1179-F1189. >>> Aliskiren; handle region peptide, rat; Saline; SC; Rat (transgenic); 2ML4; Controls received mp w/ vehicle; animal info (Ren2 Sprague Dawley heterozygous, 400-500g); Multiple pumps per animal (2); cardiovascular; peptides; diabetes;.

14366 Riera, C.E., Huising, M.O., Follett, P., Leblanc, M., Halloran, J., Van Andel, R., de Magalhaes, C.D., Merkwirth, C., Dillin, A., Dillin, A. TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling. Cell 2014; 157(--):1023-1036. >>> Calcitonin gene related peptide (8-37); Mice; Animal info (male, C57BL6J, 22 months old); functionality of mp verified by serum levels; peptides; diabetes; long-term study;.

14350 Plante, E., Menaouar, A., Danalache, B.A., Broderick, T.L., Jankowski, M., Gutkowska, J., Gutkowska, J. Treatment with brain natriuretic peptide prevents the development of cardiac dysfunction in obese diabetic db/db mice. Diabetologia 2014; 57(--):1257-1267. >>> Brain natriuretic peptide; Saline; SC; Mice; 2006; Controls received mp w/ vehicle; animal info (male, db/db, 10 weeks old); functionality of mp verified by blood plasma; long-term study; cardiovascular; diabetes;.

14342 Park, S., Kim, D.S., Kang, S., Shin, B.K., Park, S. Chronic activation of central AMPK attenuates glucose-stimulated insulin secretion and exacerbates hepatic insulin resistance in diabetic rats. Brain Research Bulletin 2014; 108(--):18-26. >>> AICAR; compound C; DMSO; CSF, artificial; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 8-10 weeks, 202.2 +/- 13.5g); diabetes; used 22 gauge cannula;.

14329 Okizaki, S., Ito, Y., Hosono, K., Oba, K., Ohkubo, H., Amano, H., Shichiri, M., Majima, M., Majima, M. Suppressed recruitment of alternatively activated macrophages reduces TGF-beta1 and impairs wound healing in streptozotocin-induced diabetic mice. BIOMEDICINE&PHARMACOTHERAPY 2015; 70(--):317-325. >>> Transforming growth factor-B1; PBS; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57Bl6, 8 weeks old, diabetes induced STZ); immunology; diabetes;.

14309 Moessenboeck, K., Vegiopoulos, A., Rose, A.J., Sijmonsma, T.P., Herzig, S., Schafmeier, T., Herzig, S. Browning of White Adipose Tissue Uncouples Glucose Uptake from Insulin Signaling. PLoS One 2014; 9(--):U1192-U1202. >>> CL316,243; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL6, 6-8 weeks old, STZ); MRI; diabetes;.

14301 Mehrotra, P., Jamwal, S.V., Saquib, N.M., Sinha, N., Siddiqui, Z., Manivel, V., Chatterjee, S., Rao, K.V.S., Rao, K.V.S. Pathogenicity of Mycobacterium tuberculosis Is Expressed by Regulating Metabolic Thresholds of the Host Macrophage. PLoS Pathogens 2014; 10(--):U589-U608. >>> Insulin, bovine; UK5099; SC; Mice; Controls received mp w/ vehicle; animal info (female, BALB/C, 4-6 weeks old); immunology; diabetes;.

14300 Meek, T.H., Matsen, M.E., Damian, V., Cubelo, A., Chua, SC Jr, Morton, G.J., Morton, G.J. Role of Melanocortin Signaling in Neuroendocrine and Metabolic Actions of Leptin in Male Rats With Uncontrolled Diabetes. Endocrinology 2014; 155(--):4157-4167. >>> SHU9119; leptin; melanotan-II;; Saline; PBS; water, sterile; CSF/CNS; SC; Rat; mice; Controls received mp w/ vehicle; animal info (rat - male, Wistar, adult; mice - STZ-DM, AgRP-deficient or WT); functionality of mp verified by decreased insulin plasma levels; Multiple pumps per animal (2); diabetes; melanotan-II aka MTII; delayed delivery - catheters filled with saline; received drug on day 5; bilateral infusion for rat;.

14296 Matavelli, L.C., Zatz, R., Siragy, H.M., Siragy, H.M. A Nonpeptide Angiotensin II Type 2 Receptor Agonist Prevents Renal Inflammation in Early Diabetes. Journal of Cardiovascular Pharmacology 2015; 65(--):371-376. >>> Compound 21; NaCl; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 230-260g); cardiovascular; diabetes;.

14288 Mamidi, R.N.V.S., Proctor, J., De Jonghe, S., Feyen, B., Moesen, E., Vinken, P., Ma, J.Y., Bryant, S., Snook, S., Louden, C., Lammens, G., Ways, K., Kelley, M.F., Johnson, M.D., Johnson, M.D. Carbohydrate malabsorption mechanism for tumor formation in rats treated with the SGLT2 inhibitor canagliflozin. Chemico-Biological Interactions 2014; 221(--):109-118. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; Animal info (male, SPF Sprague Dawley, 8-9 weeks old); cancer (renal tubular tumors); diabetes;"The loaded minipumps were stored under aseptic conditions at approximately 30–37C (in an oven) to avoid crystallization.".

14278 Lim, Y.C., Bhatt, M.P., Kwon, M.H., Park, D., Na, S., Kim, Y.M., Ha, K.S., Ha, K.S. Proinsulin C-Peptide Prevents Impaired Wound Healing by Activating Angiogenesis in Diabetes. Journal of Investigative Dermatology 2015; 135(--):269-278. >>> C-peptide; PBS; SC; Mice; 2004; Controls received sham surgery; animal info (male, C57BL6J, 6 weeks old, streptozotocin induced diabetes); cardiovascular; peptides; diabetes;.

14269 Li, Z.R., Xu, G.Y., Qin, Y., Zhang, C., Tang, H., Yin, Y., Xiang, X.X., Li, Y., Zhao, J., Mulholland, M., Zhang, W.Z., Mulholland, M. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARgamma signaling pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014; 111(--):13163-13168. >>> Ghrelin, acyl-; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL6J lean or db/db or high fat diet-induced obese, 12 weeks old); diabetes; pumps primed with 37C saline for 4 hours; obesity;.

14229 Iwasaki, Y., Maejima, Y., Suyama, S., Yoshida, M., Arai, T., Katsurada, K., Kumari, P., Nakabayashi, H., Kakei, M., Yada, T., Yada, T. Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2015; 308(--):R360-R369. >>> Oxytocin; SC; Mice; 2002; Controls received mp w/ saline; animal info (male, db/db, 11 weeks old); diabetes; obesity;.

14755 Gusarova, V., Alexa, C.A., Na, E.Q., Stevis, P.E., Xin, Y.R., Bonner-Weir, S., Cohen, J.C., Hobbs, H.H., Murphy, A.J., Yancopoulos, G.D., Gromada, J., Gusarova, V. ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion. Cell 2014; 159(--):691-696. >>> S961; PBS; Mice; 2002; Controls received mp w/ vehicle; animal info (male, Angptl8 -/-, 24-28g); peptides; diabetes; S961 is an inhibitory peptide with affinity to insulin receptor;.

14754 Gupte, A.A., Sabek, O.M., Fraga, D., Minze, L.J., Nishimoto, S.K., Liu, J.Z., Afshar, S., Gaber, L., Lyon, C.J., Gaber, A.O., Hsueh, W.A., Hsueh, W.A. Osteocalcin Protects Against Nonalcoholic Steatohepatitis in a Mouse Model of Metabolic Syndrome. Endocrinology 2014; 155(--):4697-4705. >>> Osteocalcin, bovine; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (Ldlr -/-, 12 months old); long-term study; diabetes;.

14744 Gembardt, F., Bartaun, C., Jarzebska, N., Mayoux, E., Todorov, V.T., Hohenstein, B., Hugo, C., Hugo, C. The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. American Journal of Physiology-Renal Physiology 2014; 307(--):F317-F325. >>> Angiotensin II; SC; Mice; Animal info (female, BTBR ob/ob, 8 weeks old); cardiovascular; peptides; diabetes; bp measured using tail cuff; long-term study;.

14743 Ge, H.F., Zhang, J., Gong, Y., Gupte, J., Ye, J., Weiszmann, J., Samayoa, K., Coberly, S., Gardner, J., Wang, H.L., Corbin, T., Chui, D., Baribault, H., Li, Y., Li, Y. Fibroblast Growth Factor Receptor 4 (FGFR4) Deficiency Improves Insulin Resistance and Glucose Metabolism under Diet-induced Obesity Conditions. Journal of Biological Chemistry 2014; 289(--):30470-30480. >>> Fibroblast growth factor 19, c-terminal deleted; SC; Mice; 1007D; Controls received mp w/ PBS; animal info (FGFR4 KO); diabetes;c-terminal deleted Fibroblast growth factor 19 aka FGF19dCTD; obesity;.

14738 Fukushima, A., Kinugawa, S., Takada, S., Matsushima, S., Sobirin, M.A., Ono, T., Takahashi, M., Suga, T., Homma, T., Masaki, Y., Furihata, T., Kadoguchi, T., Yokota, T., Okita, K., Tsutsui, H., Kinugawa, S. (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 307(--):E503-E514. >>> Handle region peptide; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-10 weeks old, 20-21g); ischemia (cardiac); cardiovascular; peptides; diabetes;.

14721 Dou, L., Wang, S.Y., Sui, X.F., Meng, X.Y., Shen, T., Huang, X.Q., Guo, J., Fang, W.W., Man, Y., Xi, J.Z., Li, J., Xi, J.Z. MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015; 35(--):1413-1424. >>> Interleukin-6; NaCl; BSA; SC; Mice; 2001; Animal info (male, C57BL6J, 12 weeks old); 0.1% BSA used; immunology; diabetes;.

14713 do Carmo, J.M., da Silva, A.A., Ebaady, S.E., Sessums, P.O., Abraham, R.S., Elmquist, J.K., Lowell, B.B., Hall, J.E., do Carmo, J.M. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2014; 307(--):R1438-R1447. >>> Leptin; Saline; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (Shp2 flox/flox or Shp2/Pomc-cre, 22 weeks old); behavioral testing (motor activity); cardiovascular; diabetes; bp measured using radiotelemetry; obesity study;.

14711 D'souza, A.M., Asadi, A., Johnson, J.D., Covey, S.D., Kieffer, T.J., Kieffer, T.J. Leptin Deficiency in Rats Results in Hyperinsulinemia and Impaired Glucose Homeostasis. Endocrinology 2014; 155(--):1268-1279. >>> Leptin, rat recombinant; Water; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Leptin KO, 16 weeks old); functionality of mp verified by plasma serum; diabetes;.

14701 Contreras, C., Gonzalez-Garcia, I., Martinez-Sanchez, N., Seoane-Collazo, P., Jacas, J., Morgan, D.A., Serra, D., Gallego, R., Gonzalez, F., Casals, N., Nogueiras, R., Rahmouni, K., Dieguez, C., Lopez, M., Lopez, M. Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance. CELL REPORT 2014; 9(--):366-377. >>> Sphingosine, N-hexanoyl-D-; Saline; DMSO; CSF/CNS; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); 33% DMSO used; diabetes; N-hexanoyl-D-sphingosine aka C6 ceramide;.

14672 Borg, M.L., Lemus, M., Reichenbach, A., Selathurai, A., Oldfield, B.J., Andrews, Z.B., Watt, M.J., Watt, M.J. Hypothalamic Neurogenesis Is Not Required for the Improved Insulin Sensitivity Following Exercise Training. Diabetes 2014; 63(--):3647-3658. >>> Axokine; AraC; CSF, artificial; uridine, bromodeoxy-; CSF/CNS; Mice; 1007D; 1004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 20 weeks old); diabetes; used Plastics One cannula; catheter tubing filled with vehicle or vehicle and AraC;.

14658 Altirriba, J., Poher, A.L., Caillon, A., Arsenijevic, D., Veyrat-Durebex, C., Lyautey, J., Dulloo, A., Rohner-Jeanrenaud, F., Altirriba, J. Divergent Effects of Oxytocin Treatment of Obese Diabetic Mice on Adiposity and Diabetes. Endocrinology 2014; 155(--):4189-4201. >>> Oxytocin; carbetocin; TGOT; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL/6J or ob/ob); diabetes;.

14627 Sakai, T., Kusakabe, T., Ebihara, K., Aotani, D., Yamamoto-Kataoka, S., Zhao, M.M., Gumbilai, V.M.J., Ebihara, C., izawa-Abe, M., Yamamoto, Y., Noguchi, M., Fujikura, J., Hosoda, K., Inagaki, N., Nakao, K., Kusakabe, T. Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 307(--):E712-E719. >>> Leptin, recomb.; exenatide; SC; Mice; 2002; Control animals received mp w/ saline; animal info (STZ induced diabetes, HFD 8 wks old); multiple pumps (2) implanted.

14606 Dolber, P.C., Jin, H.X., Nassar, R., Coffman, T.M., Gurley, S.B., Fraser, M.O., Dolber, P.C. The Effects of Ins2(Akita) Diabetes and Chronic Angiotensin II Infusion on Cystometric Properties in Mice. NEUROUROLOGY AND URODYNAMICS 2015; 34(--):72-78. >>> Angiotensin II; Saline; SC; Mice; 2004; Control animals received mp w/ vehicle; animal infos (C57BL/6, STZ induced diabetes, 16 wks old); peptides; post op care (local anesthetic cream).

14598 Shaqura, M., Khalefa, B.I., Shakibaei, M., Zoellner, C., Al-Khrasani, M., Fuerst, S., Schaefer, M., Mousa, S.A., Mousa, S.A. New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy. Neuropharmacology 2014; 85(--):142-150. >>> Nerve growth factor, beta; albumin, rat serum; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; Control animals received mp w/ animal info (male, Wistar, STZ induced diabetes).

14560 Mori, J., Patel, V.B., Ramprasath, T., Alrob, O.A., DesAulniers, J., Scholey, J.W., Lopaschuk, G.D., Oudit, G.Y., Oudit, G.Y. Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity. American Journal of Physiology-Renal Physiology 2014; 306(--):F812-F821. >>> Angiotensin (1-7); SC; Mice; 1002; Controls received mp w/ saline; animal info (male, C57BL6J lepr/lepr aka db/db or WT, 5 months old); cardiovascular; peptides; antihypertensive; diabetes;.

13995 Bitton-Worms, K., Rostoker, R., Braun, S., Shen-Orr, Z., LeRoith, D. The Effect of Leptin Administration on Mammary Tumor Growth in Diabetic Mice. Hormone and Metabolic Research 2013; 45(-9-):655-659. >>> Leptin, recombinant mouse; SC; Mice; 2002; Controls received mp w/ saline; animal info (female, MKR, 8-10 weeks old); cancer (breast; mammary tumors); diabetes;.

13979 van Bilsen, M., Daniels, A., Brouwers, O., Janssen, B.J.A., Derks, W.J.A., Brouns, A.E., Munts, C., Schalkwijk, C.G., van der Vusse, G.J., van Nieuwenhoven, F.A. Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice. PLoS One 2014; 9(-1-):U459-U468. >>> Angiotensin II; PBS, sterile; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, db/db or db/+, 14 weeks old); stress/adverse reaction: (see pg.2); cardiovascular; peptides; diabetes; bp measured using tail-cuff;.

13951 Yang, S.J., Lim, Y., Yang, S.J. Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation. METABOLISM-CLINICAL AND EXPERIMENTAL 2014; 63(--):693-701. >>> Resveratrol; DMSO; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57BL6); 50% DMSO used; no stress (see pg. 697); diabetes;"Resveratrol was administered via an osmotic pump, which is a safe and standard delivery system for rodents""no side effects were observed by monitoring weight change, behavior and inflammatory response around the implantation area."pg 697;.

13944 Zhang, L., Meng, S., Tu, Q.S., Yu, L.M., Tang, Y., Dard, M.M., Kim, S.H., Valverde, P., Zhou, X.D., Chen, J.K., Tu, Q.S. Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice. PLoS One 2014; 9(--):U692-U701. >>> Adiponectin; Cyclodextrin, 2-hydroxypropyl; PBS; SC; Mice; 1004; Controls received mp with vehicle; animal info (male, APN -/-, ); 2.5 hour half-life (p.e97824); immunology; diabetes;"As the APN half-life is only 2.5 h, APN was administered by systemic infusion in order to guarantee a constant blood concentration."pg e97824; 40% cyclodextrin used;.

13914 Rodgers, H.M., Liban, S., Wilson, L.M. Attenuated pain response of obese mice (B6.Cg-lep(ob)) is affected by aging and leptin but not sex. PHYSIOLOGY&BEHAVIOR 2014; 123(-;-):80-85. >>> Leptin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (ob/ob, B6.Cg-lepob, 41-42 weeks old]); behavioral testing (tail-flick, water intake); diabetes; used wound clips;.

13901 Pileggi, A., Klein, D., Fotino, C., Bravo-Egana, V., Rosero, S., Doni, M., Podetta, M., Ricordi, C., Molano, R.D., Pastori, R.L. MicroRNAs in islet immunobiology and transplantation. Immunologic Research 2013; 57(-1-3-):185-196. >>> Morpholinos; Kidney (renal subcapsular space); Rat; Gene therapy; diabetes; Used silicone catheter 3 french; morpholinos are DNA mimics, miRNA inhibitors.

13881 Pichaiwong, W., Hudkins, K.L., Wietecha, T., Nguyen, T.Q., Tachaudomdach, C., Li, W., Askari, B., Kobayashi, T., O'Brien, K.D., Pippin, J.W., Shankland, S.J., Alpers, C.E. Reversibility of Structural and Functional Damage in a Model of Advanced Diabetic Nephropathy. Journal of the American Society of Nephrology 2013; 24(-7-):1088-1102. >>> Leptin; Saline; SC; Mice; 2004; 2006; Controls received mp w/ vehicle; animal info (BTBR ob/ob, 18 weeks old); functionality of mp verified by leptin serum levels; replacement therapy (leptin replacement); diabetes; bp measured using tail cuff; long-term study;.

13839 Krautz, C., Wolk, S., Steffen, A., Knoch, K.P., Ceglarek, U., Thiery, J., Bornstein, S., Saeger, H.D., Solimena, M., Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 2013; 56(-7-):1596-1604. >>> Uridine, bromodeoxy-; everolimus; tacrolimus; mycophenolate mofetil; sirolimus; DMSO; IP; Mice; 1004; Controls received mp w/ BrdU only; animal info (C57BL6, 10-12 weeks old, STZ); functionality of mp verified by blood levels; 100% DMSO used; stress/adverse reaction: (see pg.1598); toxicology; diabetes;.

13836 Koch, C.E., Lowe, C., Pretz, D., Steger, J., Williams, L.M., Tups, A. High-Fat Diet Induces Leptin Resistance in Leptin-Deficient Mice. Journal of Neuroendocrinology 2014; 26(-2-):58-67. >>> Leptin; Cerebrospinal fluid, artificial; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; animal info (male, Lep ob/ob, 7 weeks old); behavioral testing (food intake); diabetes;.

13822 Jiao, Y., Le Lay, J., Yu, M., Naji, A., Kaestner, K.H., Kaestner, K.H. Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human beta-Cell Replication in the Transplant Setting. Diabetes 2014; 63(--):1283-1288. >>> S961; Water; SC; Mice (NOD/SCID); 2001; Controls received mp w/ vehicle; animal info (female, Nod-SCID, 8 weeks old); diabetes; S961 is an insulin receptor antagonist; infusion causes hyperglycemia in NOD/SCID.

13814 Iwasa, T., Matsuzaki, T., Munkhzaya, M., Tungalagsuvd, A., Kawami, T., Murakami, M., Yamasaki, M., Kato, T., Kuwahara, A., Yasui, T., Irahara, M., Iwasa, T. Pre-pubertal serum leptin levels and sensitivity to central leptin injection of prenatally undernourished female rats. International Journal of Developmental Neuroscience 2014; 35(--):52-54. >>> Leptin; Saline; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, PD28); functionality of mp verified by serum level; ALZET brain infusion kit 2 used; post op. care (ibuprofen, antibiotic ointment); diabetes;.

13799 Hartono, S.P., Knudsen, B.E., Lerman, L.O., Textor, S.C., Grande, J.P., Grande, J.P. Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db/db mice. BMC Nephrology 2014; 15(--):U12-U25. >>> Angiotensin II; PBS; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BLKS or C57BLKS/JLepr db/db, 5-6 weeks old, unilateral nephrectomy); cardiovascular; immunology; peptides; diabetes; bp measured using tail-cuff; long-term study;.

13797 Han, Y.M., Kang, G.M., Byun, K., Ko, H.W., Kim, J., Shin, M.S., Kim, H.K., Gil, S.Y., Yu, J.H., Lee, B., Kim, M.S., Kim, M.S. Leptin-promoted cilia assembly is critical for normal energy balance. Journal of Clinical Investigation 2014; 124(--):2193-2197. >>> Leptin; CSF/CNS; Mice; Controls received mp w/ saline; animal info (male, C57BL6, ob/ob, db/db, 12 weeks old); diabetes;.

13793 Guimaraes, P.S., Oliveira, M.F., Braga, J.F., Nadu, A.P., Schreihofer, A., Santos, R.A.S., Campagnole-Santos, M.J., Campagnole-Santos, M.J. Increasing Angiotensin-(1-7) Levels in the Brain Attenuates Metabolic Syndrome-Related Risks in Fructose-Fed Rats. Hypertension 2014; 63(--):1078-1085. >>> Angiotensin (1-7); CSF/CNS; Rat; 2004; Controls received mp w/ saline; animal info (Sprague Dawley); cardiovascular; antihypertensive; peptides; diabetes; bp measured using catheter;.

13785 Goncalves, G.H.M., Li, W.J., Garcia, A.V.C.G., Figueiredo, M.S., Bjorbaek, C., Bjorbaek, C. Hypothalamic Agouti-Related Peptide Neurons and the Central Melanocortin System Are Crucial Mediators of Leptin's Antidiabetic Actions. CELL REPORT 2014; 7(--):1093-1103. >>> Leptin; SC; Mice; 2002; Controls received mp w/ PBS; animal info (diabetic, Let ob/ob, 8 weeks old); functionality of mp verified by serum levels; diabetes;.

13765 Fang, J., Sukumaran, S., DuBois, D.C., Almon, R.R., Jusko, W.J. Meta-Modeling of Methylprednisolone Effects on Glucose Regulation in Rats. PLoS One 2013; 8(-12-):U923-U940. >>> Methylprednisolone; Rat; 2ML4; 2001; Controls received mp w/ vehicle; animal info (Wistar); functionality of mp verified by plasma levels; dose-response (pg. 11, figure 5); replacement therapy (adrenalectomy); diabetes;.

13739 Chimin, P., Farias, T.D.M., Torres-Leal, F.L., Bolsoni-Lopes, A., Campana, A.B., Andreotti, S., Lima, F.B., Lima, F.B. Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats. ACTA PHYSIOLOGICA 2014; 211(--):409-420. >>> Dexamethasone; Saline; SC; Rat; 1004; Controls received mp w/ vehicle; animal info (male, Wistar, 10 weeks old); diabetes;.

13734 Chapagain, A., Caton, P.W., Kieswich, J., Andrikopoulos, P., Nayuni, N., Long, J.H., Harwood, S.M., Webster, S.P., Raftery, M.J., Thiemermann, C., Walker, B.R., Seckl, J.R., Corder, R., Yaqoob, M.M. Elevated hepatic 11beta-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014; 111(-10-):3817-3822. >>> UE2316; DMSO; PEG 400; SC; Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 7 weeks old); 50% DMSO used; 50% PEG 400; immunology; diabetes; uremia model; UE2316 is a specific 11BHSD1 inhibitor;.

13715 Batenburg, W.W., Verma, A., Wang, Y.Y., Zhu, P., van den Heuvel, M., van Veghel, R., Danser, A.H.J., Li, Q.H., Li, Q.H. Combined Renin Inhibition/(Pro)Renin Receptor Blockade in Diabetic Retinopathy- A Study in Transgenic (mREN2)27 Rats. PLoS One 2014; 9(--):U983-U993. >>> Aliskiren; handle region peptide; Saline; SC; Rat (transgenic); 2ML4; Animal info (heterozygous Ren2 Sprague Dawley, adult, 400-500g); Multiple pumps per animal (2); cardiovascular; peptides; diabetes; handle region peptide aka HRP;.

13670 Yin, G.S., Lin, S.D., Xu, D.C., Sun, R.Q., Lin, K., Lin, C.J. Handle Region Peptide Ameliorating Insulin Resistance but Not beta Cell Functions in Male Rats Neonatally Treated with Sodium L-Glutamate. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2013; ;(-;-):U1-U11. >>> Handle region peptide; Saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 8 weeks old)); no stress (see pg.3); cardiovascular; immunology; antihypertensive; peptides; diabetes;.

13668 Wang, Y., Parlevliet, E.T., Geerling, J.J., van der Tuin, S.J.L., Zhang, H., Bieghs, V., Jawad, A.H.M., Shiri-Sverdlov, R., Bot, I., de Jager, S.C.A., Havekes, L.M., Romijn, J.A., van Dijk, K.W., Rensen, P.C.N. Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration. British Journal of Pharmacology 2014; 171(-3-):723-734. >>> Extendin-4; PBS; SC; Mice (transgenic); 1004; Controls received mp w/ vehicle; animal info (female, E3L.CETP transgenic, 12 week old); cardiovascular; immunology; peptides; diabetes;.

13663 Neumann, U.H., Chen, S., Tam, Y.Y.C., Baker, R.K., Covey, S.D., Cullis, P.R., Kieffer, T.J. IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in Male ob/ob Mice. Endocrinology 2014; 155(-3-):716-725. >>> Leptin, recombinant mouse; Water; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, ob/ob, 9 weeks old); functionality of mp verified by leptin plasma levels; diabetes; pumps primed in 37C saline for 48 hours;.

13655 Pandey, N.R., Zhou, X., Qin, Z.H., Zaman, T., Gomez-Smith, M., Keyhanian, K., Anisman, H., Brunel, J.M., Stewart, A.F.R., Chen, H.H. The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling. Journal of Neuroscience 2013; 33(-31-):12647-12655. >>> Leptin; Saline; CSF/CNS (third ventricle); Mice; Animal info (male, LMO4KO); behavioral testing (paired vs single feeding); diabetes; used guide cannula from Plastics One. used dental cement/screws.

13637 Erion, J.R., Wosiski-Kuhn, M., Dey, A., Hao, S., Davis, C.L., Pollock, N.K., Stranahan, A.M. Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity. Journal of Neuroscience 2014; 34(-7-):2618-2631. >>> IL-1 receptor antagonist; Cerebrospinal fluid, artificial; CSF/CNS (hippocampus); Mice; Animal info (male, db/db C57BL6J); functionality of mp verified by ELISA of hippocampal IL1ra; behavioral testing (spatial recognition memory testing, novel-object preference, treadmill running); tissue perfusion (hippocampus); immunology; diabetes; Cannula placement verified via histology; Used Plastics One cannula.

13629 Tsuchiya, K., Accili, D. Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance. Diabetes 2013; 62(-5-):1478-1489. >>> Insulin; PBS; Mice; 1003D; Controls received mp w/ vehicle; animal info (male, VECKO); functionality of mp verified by plasma insulin; no stress (see pg.1480); peptides; diabetes;.

13627 Sukumar, P., Viswambharan, H., Imrie, H., Cubbon, R.M., Yuldasheva, N., Gage, M., Galloway, S., Skromna, A., Kandavelu, P., Santos, C.X., Gatenby, V.K., Smith, J., Beech, D.J., Wheatcroft, S.B., Channon, K.M., Shah, A.M., Kearney, M.T. Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-Related Endothelial Cell Dysfunction. Diabetes 2007; 155(-4-):2130-2134. >>> Peptide, Gp91ds-tat; Mice; Controls received mp w/control scramble peptide; animal info (male, ESMIRO or IR +/-, 3-5 months old); no stress (see pg.2133); cardiovascular; diabetes; peptides; gp91ds-tat is a Nox2 inhibitor;.

13623 Shao, C.H., Yu, L., Gao, L. Activation of Angiotensin Type 2 Receptors Partially Ameliorates Streptozotocin-Induced Diabetes in Male Rats by Islet Protection. Endocrinology 2014; 155(-3-):793-804. >>> Compound 21; SC; Rat; Controls received mp w/ saline; animal info (male, Sprague Dawley, 280-320g); dose-response (p.797); no stress (see pg.796); behavioral testing (food and water intake); antihypertensive; diabetes; Coumpound 21 aka C21; C21 a a nonpeptide AT2R agonist;.

13612 Mori, J., Patel, V.B., Alrob, O.A., Basu, R., Altamimi, T., DesAulniers, J., Wagg, C.S., Kassiri, Z., Lopaschuk, G.D., Oudit, G.Y. Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation. Circulation-Heart Failure 2014; 7(-2-):327-339. >>> Angiotensin 1-7; Saline; SC; Mice; 1002; Controls received mp w/vehicle; animal info (male, db/db or WT, 5 months old); cardiovascular; peptides; diabetes;.

13611 Miyoshi, T., Nakamura, K., Yoshida, M., Miura, D., Oe, H., Akagi, S., Sugiyama, H., Akazawa, K., Yonezawa, T., Wada, J., Ito, H. Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats. Cardiovascular Diabetology 2014; 13(-;-):U1-U10. >>> Isoproterenol; Saline; hydrochloric acid; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 8 weeks old, 193-222g); cardiovascular; immunology; diabetes;.

13604 Li, Z.Y., Schmidt, S.F., Friedman, J.M. Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth. Diabetes 2013; 62(-7-):2359-2367. >>> Leptin; SC; Mice; 2004; Animal info (Cnrl double KO ob/ob, 12 weeks old); behavioral testing (food intake); diabetes; Pumps primed overnight in 37C saline;.

13603 Kelley, E.E., Baust, J., Bonacci, G., Golin-Bisello, F., Devlin, J.E., St Croix, C.M., Watkins, S.C., Gor, S., Cantu-Medellin, N., Weidert, E.R., Frisbee, J.C., Gladwin, M.T., Champion, H.C., Freeman, B.A., Khoo, N.K.H. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. Cardiovascular Research 2014; 101(-3-):352-363. >>> Oleic acid; nitro-octadec-9-enoic acid, 9-; nitro-octadec-9-enoic acid, 10-; PEG; ethanol; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 6-8 weeks old); long-term study; cardiovascular; immunology; diabetes; nitro-octadec-9-enoic acid aka OA-NO2;.

13593 Crepin, D., Benomar, Y., Riffault, L., Amine, H., Gertler, A., Taouis, M. The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2014; 384(-1-2-):1-11. >>> miR-200a phosphorotiate, anti-; Saline; CSF/CNS; Mice; 1002; Controls received mp w/ vehicle; animal info (male, Lep ob/ob C57BL/6, 9 weeks old)); functionality of mp verified by miRNA array; behavioral testing (food intake); gene therapy; diabetes; used dental cement and stainless steel screws;.

13589 Caruso, M.A., Sheridan, M.A. Differential regulation of the multiple insulin and insulin receptor mRNAs by somatostatin. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2014; 384(-1-2-):126-133. >>> Somatostatin, bovine; Saline; IP; Fish (trout); Controls received mp w/ vehicle; animal info (rainbow trout, juvenile, 120g); 0.75% saline used; no stress (see pg. 128); post op. care (Neosporin); behavioral testing (food intake); diabetes;.

13585 Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stange, G., Shemer, R., Nord, C., Scheel, D.W., Pan, F.C., Ahlgren, U., Gu, G.Q., Stoffers, D.A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C.V.E., Van de Casteele, M., German, M.S., Bouwens, L., Heimberg, H. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. NATURE BIOTECHNOLOGY 2014; 32(-1-):76-+. >>> Epidermal growth factor, human recombinant; ciliary neurotrophic factor, human recombinant; Acetic acid; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (ALX35d, 13 weeks old, hyperglycemic); diabetes; ciliary neurotrophic factor aka CNTF; Epidermal growth factor aka EGF;.

13576 Levy, O.E., Jodka, C.M., Ren, S.S., Mamedova, L., Sharma, A., Samant, M., D'Souza, L.J., Soares, C.J., Yuskin, D.R., Jin, L.J., Parkes, D.G., Tatarkiewicz, K., Ghosh, S.S. Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents with Extended Duration of Action. PLoS One 2014; 9(-2-):U633-U641. >>> Exenatide-ABD, [Leu14]; Sodium acetate buffer; SC; Mice; 2002; Control animals received mp w/ vehicle; animal info (Lep ob/ob); peptides; pumps replaced after 2 weeks; comparison of IP injections with SC pump; diabetes.

13562 Park, S., Kim, D.S., Kang, S., Moon, N.R. beta-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing beta-cell mass in non-diabetic and diabetic rats. METABOLISM-CLINICAL AND EXPERIMENTAL 2013; 62(-12-):1749-1760. >>> Amyloid protein, beta (25-35); amyloid protein, beta (35-25);; Saline; CSF/CNS (hippocampus); Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 232g); neurodegenerative (Alzheimer's disease); behavioral testing (passive avoidance, morris water maze); diabetes induced with pancreatectomy; amyloid protein, beta (25-35) aka AMY or amyloid protein, beta (35-25) aka RAMY; bilateral infusion;.

13561 Oh, H., Boghossian, S., York, D.A., Park-York, M. The effect of high fat diet and saturated fatty acids on insulin signaling in the amygdala and hypothalamus of rats. Brain Research 2013; 1537(-;-):191-200. >>> Palmitic acid; Cyclodextrin, hydroxypropyl b-; CSF/CNS (amygdala); Rat; 1007D; Controls received mp w/ aCSF; animal info (male, Sprague Dawley); functionality of mp verified by residual volume; behavioral testing (feeding behavior); diabetes; cannula implanted 5 days before pump implantation.

13532 Ke, J.T., Li, M., Xu, S.Q., Zhang, W.J., Jiang, Y.W., Cheng, L.Y., Chen, L., Lou, J.N., Wu, W. Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats. Journal of Endocrinology 2014; 220(-2-):129-141. >>> Gliquidone; Dimethylformamide; IP; Rat; Animal info (male, SPF-grade, Goto-Kakizaki, 8 weeks old, 250-300g); functionality of mp verified by blood drug levels; 99.8% dimethylformamide used; comparison of intragastric administration vs mp (pg.133); stability verified by (plasma serum); diabetes;.

13486 Emanuelli, B., Vienberg, S.G., Smyth, G., Cheng, C., Stanford, K.I., Arumugam, M., Michael, M.D., Adams, A.C., Kharitonenkov, A., Kahn, C.R. Interplay between FGF21 and insulin action in the liver regulates metabolism. Journal of Clinical Investigation 2014; 124(-2-):515-527. >>> Fibroblast growth factor 21; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, WT (IRLox) and LIRKO); diabetes;.

13478 O'Neill, C.M., Lu, C., Corbin, K.L., Sharma, P.R., Dula, S.B., Carter, J.D., Ramadan, J.W., Xin, W.J., Lee, J.K., Nunemaker, C.S. Circulating Levels of IL-1B+IL-6 Cause ER Stress and Dysfunction in Islets From Prediabetic Male Mice. Endocrinology 2013; 154(-9-):3077-3088. >>> Interleukin-1, beta; Interleukin-6; Saline; SC; Mice; 1007D; Controls received mp w/ vehicle or sham surgery; animal info (male, CD1 5 weeks old, C57BL6J 11 weeks old); functionality of mp verified by measurement of serum levels; no stress (see pg. 3084); immunology; diabetes, Pumps primed 18-22 h at 37C.

13475 Palei, A.C., Spradley, F.T., Granger, J.P. Euglycemic Hyperinsulinemia Increases Blood Pressure in Pregnant Rats Independent of Placental Antiangiogenic and Inflammatory Factors. American Journal of Hypertension 2013; 26(-11-):1445-1451. >>> Insulin; SC; Rat (pregnant); 1007D; Animal info (female, Sprague Dawley); functionality of mp verified by serum insulin levels; cardiovascular; peptides; diabetes;.

13473 Camporez, J.P.G., Jornayvaz, F.R., Petersen, M.C., Pesta, D., Guigni, B.A., Serr, J., Zhang, D.Y., Kahn, M., Samuel, V.T., Jurczak, M.J., Shulman, G.I. Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice. Endocrinology 2013; 154(-9-):3099-3109. >>> Fibroblast growth factor 21, human recombinant; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6, 3 months old); functionality of mp verified by plasma serum levels; behavioral testing (energy expenditure, locomotor activity); diabetes;.

13453 Shao, C.H., Zucker, I.H., Gao, L. Angiotensin type 2 receptor in pancreatic islets of adult rats: a novel insulinotropic mediator. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013; 305(-10-):E1281-E1291. >>> Angiotensin II; Losartan; Compound 21; PD123319; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 320-360g); cardiovascular; peptides; diabetes; C21 is an AT2R agonist. PD123319 is an AT2R antagonist; bp measured using radiotelemetry (DSI);.

13441 Tak, E., Ridyard, D., Badulak, A., Giebler, A., Shabeka, U., Werner, T., Clambey, E., Moldovan, R., Zimmerman, M.A., Eltzschig, H.K., Grenz, A. Protective role for netrin-1 during diabetic nephropathy. JOURNAL OF MOLECULAR MEDICINE-JMM 2013; 91(-9-):1071-1080. >>> Netrin-1; SC; Mice; 2006; Controls received mp w/ vehicle; animal info (STZ mice); pumps replaced every 6 weeks; diabetes.

13437 Terasaki, M., Nagashima, M., Nohtomi, K., Kohashi, K., Tomoyasu, M., Sinmura, K., Nogi, Y., Katayama, Y., Sato, K., Itoh, F., Watanabe, T., Hirano, T. Preventive Effect of Dipeptidyl Peptidase-4 Inhibitor on Atherosclerosis Is Mainly Attributable to Incretin's Actions in Nondiabetic and Diabetic Apolipoprotein E-Null Mice. PLoS One 2013; 8(-8-):U285-U296. >>> Exendin (9-39); (Pro3)GIP; Saline; Mice (transgenic); 1007D; Controls received mp w/ vehicle; animal info (male, Apoe -/- STD, db/db); no stress (see pg. e70933); cardiovascular; diabetes; Pro3 is a GIP receptor blocker. Extendin is a GL.

13435 Tian, J.D., Dang, H., Chen, Z.Y., Guan, A., Jin, Y.L., Atkinson, M.A., Kaufman, D.L. gamma-Aminobutyric Acid Regulates Both the Survival and Replication of Human beta-Cells. Diabetes 2013; 62(-11-):3760-3765. >>> Muscimol; PBS; SC; Mice (NOD/SCID); 1002; Controls received mp w/ vehicle; animal info (male, C57BL6, 10 weeks old; NOD/SCID); diabetes.

13423 Yang, Y.J., Tarabra, E., Yang, G.S., Vaitheesvaran, B., Palacios, G., Kurland, I.J., Pessin, J.E., Bastie, C.C. Alteration of De Novo Glucose Production Contributes to Fasting Hypoglycaemia in Fyn Deficient Mice. PLoS One 2013; 8(-11-):U566-U574. >>> Glucose, U-13C6; glycerol, U-13C; SC; Mice; 2001; Animal info (FynKO (pp59Fyn), 8-10 weeks old; control (129SvJ, 8-10 weeks old)); diabetes;.

13412 Liu, Y., Jia, Z.J., Liu, S.S., Downton, M., Liu, G., Du, Y.M., Yang, T.X. Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice. American Journal of Physiology-Renal Physiology 2013; 305(-11-):F1555-F1562. >>> Nitro-oleic acid; Ethanol; SC; Mice; Controls received mp w/ vehicle;animal info (male, Lepr db/db, 12 weeks old); diabetes.

13408 Lin, Z.F., Tian, H.S., Lam, K.S.L., Lin, S.Q., Hoo, R.C.L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S.R., Xu, A.M., Li, X.K. Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice. Cell Metabolism 2013; 17(-5-):779-789. >>> Fibroblast growth factor 21; SC; Mice; Controls received mp w/ vehicle; animal info (male, FGF21 KO, ADNKO); functionality of mp verified by plasma serum levels; immunology; diabetes.

13390 Kaida, Y., Fukami, K., Matsui, T., Higashimoto, Y., Nishino, Y., Obara, N., Nakayama, Y., Ando, R., Toyonaga, M., Ueda, S., Takeuchi, M., Inoue, H., Okuda, S., Yamagishi, S. DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy. Diabetes 2013; 62(-9-):3241-3250. >>> Advanced glycation end products aptamer; IP; Mice; 1004; Controls received mp w/ control aptamer; animal info (male, KKay/TA or C57BL6J, 8 weeks old); functionality of mp verified by serum AGE levels; half-life 7 days (p. 3241); gene therapy; diabetes; Advanced glycation end products aptamer aka AGEs-aptamer; Pumps removed after 7 day infusion.

13385 Holland, W.L., Adams, A.C., Brozinick, J.T., Bui, H.H., Miyauchi, Y., Kusminski, C.M., Bauer, S.M., Wade, M., Singhal, E., Cheng, C.C., Volk, K., Kuo, M.S., Gordillo, R., Kharitonenkov, A., Scherer, P.E. An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice. Cell Metabolism 2013; 17(-5-):790-797. >>> Fibroblast growth factor 21; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (Lep ob/ob, 14-16 weeks old); behavioral testing (energy expenditure); diabetes.

13353 Bhatt, M.P., Lim, Y.C., Kim, Y.M., Ha, K.S. C-Peptide Activates AMPKalpha and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes. Diabetes 2013; 62(-11-):3851-3862. >>> C-peptide; PBS; SC; Mice; 2004; Controls received sham surgery; animal info (male, STZ, C57BL6, 6 weeks old); functionality of mp verified by serum C-peptide levels; immunology; peptides; diabetes.

13346 Awad, A.S., Gao, T., Gvritishvili, A., You, H.N., Liu, Y.L., Cooper, T.K., Reeves, W.B., Tombran-Tink, J. Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury. American Journal of Physiology-Renal Physiology 2013; 305(-6-):F891-F900. >>> Pigment epithelium-derived factor; PBS; SC; Mice; 2006; Controls received mp w/ vehicle; animal info (male, DBA/2J, 6 weeks old); immunology; peptides; diabetes; Pigment epithelium-derived factor aka PEDF; long-term study;.

13296 Nguyen, T.D., Shingu, Y., Amorim, P.A., Schwarzer, M., Doenst, T. Glucagon-like peptide-1 reduces contractile function and fails to boost glucose utilization in normal hearts in the presence of fatty acids. International Journal of Cardiology 2013; 168(-4-):4085-4092. >>> Glucagon-like peptide-1; Saline; IV (jugular vein); Rat; 2ML4; Cardiovascular; peptides; animal info (male, Sprague Dawley rats, 250-350g, 110-130g); functionality verified by residual volume; diabetes;.

13287 Fujikawa, T., Berglund, E.D., Patel, V.R., Ramadori, G., Vianna, C.R., Vong, L., Thorel, F., Chera, S., Herrera, P.L., Lowell, B.B., Elmquist, J.K., Baldi, P., Coppari, R. Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin. Cell Metabolism 2013; 18(-3-):431-444. >>> Leptin; PBS; CSF/CNS; Mice; Controls received mp w/ PBS; Interesting paper; leptin administration permits survival and improves hyperglycemia of mice totally lacking insulin via CNS-dependent mechanisms. Leptin also lowers circulating and effect of glucagon. Effect is not through alpha pancreatic cells, but indirectly through hypothalamic GABA neurons; diabetes;.

13275 Gaspari, T., Welungoda, I., Widdop, R.E., Simpson, R.W., Dear, A.E. The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE(-/-) mouse model. Diabetes&Vascular Disease Research 2013; 10(-4-):353-360. >>> Liraglutide; exendin-9; Saline; SC; Mice; 1004; Animal info (B6ApoE-/-, male, 25-35g, 5 weeks old); half-life (10-14 hours); diabetes;.

13257 Li, Z.R., Gao, L., Tang, H., Yin, Y., Xiang, X.X., Li, Y., Zhao, J., Mulholland, M., Zhang, W.Z. Peripheral Effects of Nesfatin-1 on Glucose Homeostasis. PLoS One 2013; 8(-8-):U595-U604. >>> Nesfatin-1; CSF/CNS; Mice; 1002; Animal info (C57BL/6J, 12 weeks, male); dose response (Fig. 2C); diabetes;.

13243 Hokke, S.N., Armitage, J.A., Puelles, V.G., Short, K.M., Jones, L., Smyth, I.M., Bertram, J.F., Cullen-McEwen, L.A. Altered Ureteric Branching Morphogenesis and Nephron Endowment in Offspring of Diabetic and Insulin-Treated Pregnancy. PLoS One 2013; 8(-3-):U453-U461. >>> Insulin; Saline; Mice; 1007D; Controls received mp w/ saline; Peptides; animal info (8-12wk, C57BL/6J, mice (pregnant)); mp used to infuse insulin to study the effect of hyperglycemia and glycemic control on ureteric branching during pregnancy; diabetes;.

13224 Bonner, J.S., Lantier, L., Hocking, K.M., Kang, L., Owolabi, M., James, F.D., Bracy, D.P., Brophy, C.M., Wasserman, D.H. Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet. Diabetes 2013; 62(-9-):3251-3260. >>> Relaxin-2, recomb. human;; Sodium acetate; SC; Mice; 2001; 2002; Peptides; animal info (male, 6wks, C57BL/6J); pumps replaced every (2 weeks); diabetes;.

13223 Trevaskis, J.L., Mack, C.M., Sun, C.Z., Soares, C.J., D'Souza, L.J., Levy, O.E., Lewis, D.Y., Jodka, C.M., Tatarkiewicz, K., Gedulin, B., Gupta, S., Wittmer, C., Hanley, M., Forood, B., Parkes, D.G., Ghosh, S.S. Improved Glucose Control and Reduced Body Weight in Rodents with Dual Mechanism of Action Peptide Hybrids. PLoS One 2013; 8(-10-):U713-U724. >>> AC164204; AC164209; exenatide; davalintide; DMSO; bovine serum albumin; SC; Rat; Peptides; 50% DMSO used; Dose-response (Fig. 5); diabetes;.

13221 Thomas, C.M., Yong, Q.C., Seqqat, R., Chandel, N., Feldman, D.L., Baker, K.M., Kumar, R. Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clinical Science 2013; 124(-7-8-):529-541. >>> Insulin; aliskiren (renin inhibitor); benazeprilat (ACEi); valsartan (ARB); streptozotocin; Saline; SC; Mice; 1004; Controls received mp w/vehicle, or (0.1M sodium citrate buffer (pH 4.5)); cardiovascular; animal info (male, C57b16/J, 12 weeks, blood glucose>250 mg/dl); pumps replaced every 4 weeks; enzyme inhibitor (renin); long-term study; diabetes;.

13192 Chhabra, K.H., Xia, H.J., Pedersen, K.B., Speth, R.C., Lazartigues, E. Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013; 304(-8-):E874-E884. >>> Angiotensin II; Saline; IP; 2002; Controls received mp w/ saline; antihypertensive; peptides; animal info (male, C57b1/6J, 8-10 wks old); dose-response (Fig.4); diabetes;.

13179 Novikova, L., Smirnova, I.V., Rawal, S., Dotson, A.L., Benedict, S.H., Stehno-Bittel, L. Variations in Rodent Models of Type 1 Diabetes: Islet Morphology. JOURNAL OF DIABETES RESEARCH 2013; ;(-;-):U1-U13. >>> Insulin; SC; Rat; Peptides; animal info (BBDR, rat, 23-25 days); functionality of mp verified by measuring blood glucose levels; diabetes;.

13154 Denroche, H.C., Quong, W.L., Bruin, J.E., Tuduri, E., Asadi, A., Glavas, M.M., Fox, J.K., Kieffer, T.J. Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice. Diabetes 2013; 62(-8-):2738-2746. >>> Leptin, recomb. murine; Water; SC; Mice; 2006; Control animals received mp w/ vehicle; animal info (C57BL/6, male); dose-response; 4 week pumps used; diabetes; long-term study;.

13153 Tatarkiewicz, K., Hargrove, D.M., Jodka, C.M., Gedulin, B.R., Smith, P.A., Hoyt, J.A., Lwin, A., Collins, L., Mamedova, L., Levy, O.E., D'Souza, L., Janssen, S., Srivastava, V., Ghosh, S.S., Parkes, D.G. A novel long-acting glucose-dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodents. DIABETES OBESITY&METABOLISM 2013; 16(-1-):75-85. >>> AC3174; SC; Mice; 2002; Animal info (HSD:NIHS, DIO); pumps replaced after 2 weeks; diabetes;.

13152 Jin, H.M., Zhou, D.C., Gu, H.F., Qiao, Q.Y., Fu, S.K., Liu, X.L., Pan, Y. Antioxidant N-Acetylcysteine Protects Pancreatic beta-Cells Against Aldosterone-Induced Oxidative Stress and Apoptosis in Female db/db Mice and Insulin-Producing MIN6 Cells. Endocrinology 2013; 154(-11-):4068-4077. >>> Aldosterone; SC; Mice; 2ML4; Animal info (C57BLKS/J, db/db, female, 8 wks old); long-term study; diabetes;.

13146 Dauch, J.R., Bender, D.E., Luna-Wong, L.A., Hsieh, W., Yanik, B.M., Kelly, Z.A., Cheng, H.T. Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia. Journal of Neuroinflammation 2013; 10(-;-):U1-U10. >>> SB203580; DMSO; CSF/CNS (intrathecal); 1007D; Control animals received mp w/ vehicle; animal info (C57BLKS, male, db/db, 7 wks old); 10% DMSO used; enzyme inhibitor (p38 kinase); diabetes;.

13143 Liu, J., Wang, N., Xie, F., Sun, L.H., Chen, Q.X., Ye, J.H., Cai, B.Z., Yang, B.F., Ai, J. Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Baroreflex Sensitivity of Diabetic Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2013; 31(-2-3-):421-431. >>> BIBP 3226; BIIE 0246; SC; Rat; Animal info (Wistar, male, 230-270 g, 3-4 mo old, DM); BIBP 3226 is a Y1R antagonist; BIIE 0246 is a Y2R receptor antagonist; diabetes;.

13100 Abe, H., Uchida, T., Hara, A., Mizukami, H., Komiya, K., Koike, M., Shigihara, N., Toyofuku, Y., Ogihara, T., Uchiyama, Y., Yagihashi, S., Fujitani, Y., Watada, H. Exendin-4 Improves beta-Cell Function in Autophagy-Deficient beta-Cells. Endocrinology 2013; 154(-12-):4512-4524. >>> Exendin-4; Mice; 1004; Control animals received mp w/ saline; animal info (Atg f/f, Atg 7 delta beta cell, 8-12 wks old; db/db , db/misty 6-10 wks old); incorrectly spelled ALZET (ALZEST); diabetes;.

13099 Meek, T.H., Matsen, M.E., Dorfman, M.D., Guyenet, S.J., Damian, V., Nguyen, H.T., Taborsky, GJ Jr, Morton, G.J. Leptin Action in the Ventromedial Hypothalamic Nucleus Is Sufficient, But Not Necessary, to Normalize Diabetic Hyperglycemia. Endocrinology 2013; 154(-9-):3067-3076. >>> Leptin; PBS; CSF/CNS; Mice; Control animals received mp w/ vehicle; animal info (STZ induced diabetes, Lepr wt, Lepr KO VMN); diabetes;.

13097 Supale, S., Thorel, F., Merkwirth, C., Gjinovci, A., Herrera, P.L., Scorrano, L., Meda, P., Langer, T., Maechler, P. Loss of Prohibitin Induces Mitochondrial Damages Altering beta-Cell Function and Survival and Is Responsible for Gradual Diabetes Development. Diabetes 2013; 62(-10-):3488-3499. >>> Leptin, human; SC; Mice; 1002; Control animals received mp w/ saline; animal info (8 wks old, Phb2 KO); diabetes;.

12960 Lindtner, C., Scherer, T., Zielinski, E., Filatova, N., Fasshauer, M., Tonks, N.K., Puchowicz, M., Buettner, C. Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action. Science Translational Medicine 2013; 5(-170-):U17-U29. >>> PS1145; CPT-157633; Cyclodextrin, beta; CSF, artificial; CSF/CNS; Rat; 1004; Animal info (Sprague Dawley, female, 14 wks old); ALZET brain infusion kit 2 used; 7.75% cyclodextrin used; diabetes.

12907 Gutierrez-Rojas, I., Lozano, D., Nuche-Berenguer, B., Moreno, P., Acitores, A., Ramos-Alvarez, I., Rovira, A., Novials, A., Martin-Crespo, E., Villanueva-Penacarrillo, M.L., Esbrit, P. Amylin exerts osteogenic actions with different efficacy depending on the diabetic status. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2013; 365(-2-):309-315. >>> Amylin; Saline; SC; Rat; 1003D; Control animals received mp w/ vehicle; animal info (N, IR, T2D); diabetes; peptides.

12857 Mousa, S.A., Shaqura, M., Khalefa, B.I., Zoellner, C., Schaad, L., Schneider, J., Shippenberg, T.S., Richter, J.F., Hellweg, R., Shakibaei, M., Schaefer, M. Rab7 Silencing Prevents mu-Opioid Receptor Lysosomal Targeting and Rescues Opioid Responsiveness to Strengthen Diabetic Neuropathic Pain Therapy. Diabetes 2013; 62(-4-):1308-1319. >>> Nerve growth factor, beta; CSF, artificial; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2001; Control animals received mp w/ vehicle; animal info (Wistar, male, STZ induced diabetes).

12761 Kakimoto, T., Kimata, H., Iwasaki, S., Fukunari, A., Utsumi, H. Automated recognition and quantification of pancreatic islets in Zucker diabetic fatty rats treated with exendin-4. Journal of Endocrinology 2013; 216(-1-):13-20. >>> Exendin-4; PBS; SC; Rat; Control animals received mp w/ vehicle; animal info (ZDF, lean, 5 weeks old); long-term study; diabetes.

12760 Luo, M., Guan, X.Q., Luczak, E.D., Lang, D., Kutschke, W., Gao, Z., Yang, J.Y., Glynn, P., Sossalla, S., Swaminathan, P.D., Weiss, R.M., Yang, B.L., Rokita, A.G., Maier, L.S., Efimov, I.R., Hund, T.J., Anderson, M.A. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. Journal of Clinical Investigation 2013; 123(-3-):1262-1274. >>> MitoTEMPO; SC; Mice; 1004; Animal info (Ncf 1 -/-; 3-5 mo old); MitoTEMPO is a mitochondrial targeted antioxidant; diabetes.

 

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“Insofar as multiple dosing is concerned, we propose that only administration by pump (or administration more than four times a day) can provide clinical-like occupancies for haloperidol, olanzapine, and risperidone.” Kapur et al., The Journal of Pharmacology and Experimental Therapeutics 2003;305:625-631.