References on Diabetes Research Using ALZET^® Osmotic Pumps

Q0706 Dhar,A., Dhar,I., Jiang,B., Desai,K.M., Wu,L.Y. Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic beta-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats. Diabetes 2011; 60(-3-):899-908. >>> Methylglyoxal; SC; Rat; 2ML4; 28 days; Controls received mp w/ saline; animal info (male, Sprague Dawley, 11 wks old); no stress (see pg. 899) "no inflammatory infiltrate or response in the animals with the infusion or the pump implantation"; diabetes.

Q0834 Liu,J., Gao,B.B., Clermont,A.C., Blair,P., Chilcote,T.J., Sinha,S., Flaumenhaft,R., Feener,E.P. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nature Medicine 2011; 17(-2-):206-U99. >>> ASP-440; Polyethylene glycol; PBS; SC; Rat; ; Controls received mp w/ vehicle; animal info (Sprague-Dawley, STZ-induced diabetes); ASP-440 also known as 1-benzyl-1H-pyrazole-4-carboxylic acid 4-carbamimidoyl-benzylamide is a small-molecule PK inhibitor.

Q0506 Adam,A., Leclair,P., Montpas,N., Koumbadinga,G.A., Bachelard,H., Marceau,F. Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases. Neuropeptides 2010; 44(-2-):69-75. >>> Insulin, regular; IP; Rat; 2ML2; 7 days; Controls received no treatment; animal info (diabetic, Sprague Dawley, 125-150 g.); diabetes.

Q0322 Annaba,F., Ma,K., Kumar,P., Dudeja,A.K., Kineman,R.D., Shneider,B.L., Saksena,S., Gill,R.K., Alrefai,W.A. Ileal apical Na(+)-dependent bile acid transporter ASBT is upregulated in rats with diabetes mellitus induced by low doses of streptozotocin. American Journal of Physiology-Gastrointestinal and Liver Physiology 2010; 299(-4-):G898-G906. >>> Insulin, human; SC; Rat; 2ML1; 3 days; Animal info (Sprague-Dawley, males, 7-8 wks old, 200-250 g); diabetes; "Upon insulin treatment from subcutaneous osmotic pumps, glucose levels were restored to normal" pg G904; streptozotocin-induced diabetes.

Q0105 Arakawa,M., Mita,T., Azuma,K., Ebato,C., Goto,H., Nomiyama,T., Fujitani,Y., Hirose,T., Kawamori,R., Watada,H. Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4. Diabetes 2010; 59(-4-):1030-1037. >>> Exendin-4; SC; Mice; 1004; 28 days; Controls received mp w/ saline; animal info (C57BL/6, 7 wks old male, apoe-1-, 6 wks old); diabetes; wound clips used.

Q0155 Cheng,H.T., Dauch,J.R., Oh,S.S., Hayes,J.M., Hong,Y., Feldman,E.L. p38 mediates mechanical allodynia in a mouse model of type 2 diabetes. Molecular Pain 2010; 6(-;-):U1-U14. >>> SB203580; CSF, artificial; DMSO; CSF/CNS (intrathecal); Mice; 1007D; 1 week; Animal info (db+, db/db, 8 wks old); 10% DMSO used; diabetes; PE cannula used to target the L5 region.

Q0473 Frangioudakis,G., Garrard,J., Raddatz,K., Nadler,J.L., Mitchell,T.W., Schmitz-Peiffer,C. Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors. Endocrinology 2010; 151(-9-):4187-4196. >>> Lisofylline; Saline; SC; Mice; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (male, C57/BL6, 6 wks old); enzyme inhibitor (lysophosphatidic acid acyl transferase, LPAAT); diabetes; obesity.

Q0166 Imran,S.A., Brown,R.E., Wilksinson,M. Tissue-specific effects of valsartan on rstn and fiaf gene expression in the ob/ob mouse. Diabetes and Vascular Disease Research 2010; (--):1-8. >>> Valsartan; DMSO; water; sodium hydroxide; SC; Mice; 1002; 14 days; Controls received sham operation; animal info (male, C57BL/6, lean, obese, 13 wks old); wound clips used; diabetes.

Q0082 Kaiyala,K.J., Morton,G.J., Leroux,B.G., Ogimoto,K., Wisse,B., Schwartz,M.W. Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice. Diabetes 2010; 59(-7-):1657-1666. >>> Leptin; Sodium bicarbonate; SC; Mice; 1007D; ; Controls received mp w/ vehicle; animal info (ob/ob, wt, C57BL/6, 11 wks old); obesity; diabetes; Lynch coil filled with saline for 24 hour delayed infusion.

P9977 Koitka,A., Cao,Z., Koh,P., Watson,A.M.D., Sourris,K.C., Loufrani,L., Soro-Paavonen,A., Walther,T., Woollard,K.J., Jandeleit-Dahm,K.A.M., Cooper,M.E., Allen,T.J. Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes. Diabetologia 2010; 53(-3-):584-592. >>> PD123319; Water, Milli Q; SC; Mice; 2004; 20 weeks; Long-term study; pumps replaced every 28 days; animal info (ApoE -/-, diabetic); diabetes.

Q0477 Li,J.H., Qu,X.L., Yao,J., Caruana,G., Ricardo,S.D., Yamamoto,Y., Yamamoto,H., Bertram,J.F. Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy. Diabetes 2010; 59(-10-):2612-2624. >>> SIS3; advanced glycation end products; Albumin, mouse serum; SC; Mice; 1 month; 8 weeks; Controls received mp w/ vehicle; animal info (male, Tie2-Cre;Loxp-EGFP, C57BL/6J, 20-25g, STZ induced diabetes); long-term study; SIS3 is a specific Smad3 inhibitor.

Q0475 Ma,H., Lu,Y., Li,H., Campbell-Thompson,M., Parker,M., Wasserfall,C., Haller,M., Brantly,M., Schatz,D., Atkinson,M., Song,S. Intradermal alpha 1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease. Diabetologia 2010; 53(-10-):2198-2204. >>> Antitrypsin, human, alpha-1; SC; Mice; 7 days; Animal info (8 wks old, female, NOD); comparison of IP, SC injections vs mp; diabetes; hAAT also known as Prolastin; "...repeated administration of hAAT may lead to fatal anaphylaxis in NOD mice... Delivery of AAT by an osmotic pump resulted in a twofold increase of the AUC0-7days suggesting a possible clinical application in large animals and in humans." pg 2202.

Q0353 Moore,D.J., Zienkiewicz,J., Kendall,P.L., Liu,D.Y., Liu,X.Y., Veach,R.A., Collins,R.D., Hawiger,J. In Vivo Islet Protection by a Nuclear Import Inhibitor in a Mouse Model of Type 1 Diabetes. PLoS One 2010; 5(-10-):U183-U194. >>> SN50, c-; SC; Mice; 1003D; 4 days; Controls received mp w/ saline; animal info (NOD, BDC2.5, TCR, transgenic); peptides; diabetes.

P9976 Nordquist,L., Shimada,K., Ishii,T., Furuya,D.T., Kamikawa,A., Kimura,K. Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase alpha-1-subunit in rats. DIABETES-METABOLISM RESEARCH AND REVIEWS 2010; 26(-3-):193-199. >>> C-peptide, human; insulin, recomb. human; SC; Rat; 2ML2; 1 weeks; Controls received mp w/ saline; animal info (male, Sprague Dawley, 15 wks old, 350-450 g.); replacement therapy (STZ-induced Diabetes).

Q0163 Park,S., Ahn,I.S., Kim,D.S. Central infusion of leptin improves insulin resistance and suppresses beta-cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model. LIFE SCIENCES 2010; 86(-23-24-):854-862. >>> Leptin; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 223 g.); aCSF recipe; diabetes.

Q0162 Sakata,A., Mogi,M., Iwanami,J., Tsukuda,K., Min,L.J., Jing,F., Iwai,M., Ito,M., Horiuchi,M. Female exhibited severe cognitive impairment in type 2 diabetes mellitus mice. LIFE SCIENCES 2010; 86(-17-18-):638-645. >>> Estradiol, beta-; Propylene glycol; IP; Mice; 1002; ; Replacement therapy (ovariectomy); animal info (8-12 wks old, C57BL/6, KKAY); diabetes.

Q0106 Sarruf,D.A., Thaler,J.P., Morton,G.J., German,J., Fischer,J.D., Ogimoto,K., Schwartz,M.W. Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats. Diabetes 2010; 59(-7-):1817-1824. >>> Fibroblast growth factor-21, recomb. human; BSA; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (male, Wistar, 250-275 g); Research diets D12492; diabetes.

Q0030 Searls,Y.M., Loganathan,R., Smirnova,I.V., Stehno-Bittel,L. Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia. Cardiovascular Diabetology 2010; 9(-;-):U1-U17. >>> Insulin; SC; Rat; 2004; 28 days; Controls received mp w/saline; peptides; animal info (male, DR-BB Wistar, 21-26 days old); comparison of SC injections vs. mp; replacement therapy (anti-RT6 mAB-induced diabetes); endocrinology; Humulin R, Humulin U and Humulin N used;.

Q0703 Tatarkiewicz,K., Smith,P.A., Sablan,E.J., Polizzi,C.J., Aumann,D.E., Villescaz,C., Hargrove,D.M., Gedulin,B.R., Lu,M.G.W., Adams,L., Whisenant,T., Roy,D., Parkes,D.G. Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2010; 299(-6-):E1076-E1086. >>> Exenatide; DMSO; water, sterile; SC; Mice; 2002; 4 weeks; Controls received mp w/ vehicle; animal info (C57BL/6, ob/ob); pumps replaced after 2 weeks; 50% DMSO used; diabetes.

Q0504 Arakawa,M., Ebato,C., Mita,T., Hirose,T., Kawamori,R., Fujitani,Y., Watada,H. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochemical and Biophysical Research Communications 2009; 390(-3-):809-814. >>> Exendin-4; Mice; 1004; 28 days; Controls received mp w/ saline; animal info (male, C57BL/6, 4 wks old); diabetes.

Q0464 Chen,S.R., Samoriski,G., Pan,H.L. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology 2009; 57(-2-):121-126. >>> Neramexane mesylate; memantine; gabapentin; Saline, sterile; water; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; animal info (male, 225-250 g, STZ induced diabetes); functionality of mp verified by plasma drug levels; post op. care (penicillin); wound clips used; neuropathic pain.

Q0443 da Silva,A.A., do Carmo,J.M., Freeman,J.N., Tallam,L.S., Hall,J.E. A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin. Diabetes 2009; 58(-8-):1749-1756. >>> Leptin; SHU-9119; CSF/CNS; Rat; 2002; 10, 17 days; Animal info (male, Sprague-Dawley, 325-350 g); pumps replaced after 7 days; multiple pumps per animal (2); guide cannula used; cannula placement verified by angiotensin II dipsogenic effect; diabetes; Leptin and SHU-9119 attached to Y connector.

Q0594 Granado,M., Chowen,J.A., Garcia-Caceres,C., gado-Rubin,A., Barrios,V., Castillero,E., Argente,J., Frago,L.M. Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2009; 309(-1-2-):67-75. >>> Ghrelin, n-octanoyl; IV (jugular); Rat; ; Controls received mp w/ saline; animal info (adult, male, Wistar, 250 g, STZ induced diabetes); infusion rate of 0.5 ul/hr.

Q0445 Hong,E.G., Ko,H.J., Cho,Y.R., Kim,H.J., Ma,Z.X., Yu,T.Y., Friedline,R.H., Kurt-Jones,E., Finberg,R., Fischer,M.A., Granger,E.L., Norbury,C.C., Hauschka,S.D., Philbrick,W.M., Lee,C.G., Elias,J.A., Kim,J.K. Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle. Diabetes 2009; 58(-11-):2525-2535. >>> Interleukin-10; Mice; 3 days; Controls received mp w/saline; animal info (male, C57BL/6, 10 wks old); diabetes.

Q0570 Petersen,P.S., Woldbye,D.P.D., Madsen,A.N., Egerod,K.L., Jin,C.Y., Lang,M., Rasmussen,M., Beck-Sickinger,A.G., Holst,B. In Vivo Characterization of High Basal Signaling from the Ghrelin Receptor. Endocrinology 2009; 150(-11-):4920-4930. >>> Substance P; PBS; BSA; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle or inactive control peptide; animal info (Male Wistar, 275-300 g, STZ induced diabetes); peptides.

P9797 Phipps,J.A., Clermont,A.C., Sinha,S., Chilcote,T.J., Bursell,S.E., Feener,E.P. Plasma Kallikrein Mediates Angiotensin II Type 1 Receptor-Stimulated Retinal Vascular Permeability. Hypertension 2009; 53(-2-):175-U127. >>> Angiotensin II; Hoe 140; PBS; polyethylene glycol; saline; SC; Rat; 8 weeks; 1, 3, 6 days; Controls received mp w/ vehicle; peptides; animal info (8 wks old, male, Sprague Dawley, diabetes mellitus).

P9828 Piriz,J., Torres-Aleman,I., Nunez,A. INDEPENDENT ALTERATIONS IN THE CENTRAL AND PERIPHERAL SOMATOSENSORY PATHWAYS IN RAT DIABETIC NEUROPATHY. Neuroscience 2009; 160(-2-):402-411. >>> Immunoglobulin growth factor-1, recomb. human; NaCl; SC; Rat; 2004; 28 days; Controls received no treatment; animal info (male, Wistar, 16 wks old); diabetes.

P9891 Ramadori,G., Gautron,L., Fujikawa,T., Vianna,C.R., Elmquist,J.K., Coppari,R. Central Administration of Resveratrol Improves Diet-Induced Diabetes. Endocrinology 2009; 150(-12-):5326-5333. >>> Resveratrol; Saline, sterile; CSF/CNS; Mice; 1004; 5 weeks; Controls received mp w/vehicle; animal info (C57BL/6, male); "This daily dose of resveratrol (0.03mg/ul) is approximately 8.5 million or approximately 152 million times lower, respectively, compared with the dose orally delivered in two previous studies" pg 5327; diabetes; endocrinology.

Q0576 Serbedzija,P., Madl,J.E., Ishii,D.N. Insulin and IGF-I prevent brain atrophy and DNA loss in diabetes. Brain Research 2009; 1303(-;-):179-194. >>> Insulin; insulin-like growth factor-I; CSF/CNS; Rat; 12 weeks; Controls received mp w/ aCSF; animal info (Wistar, 275-300 g adult, 9 wks old, male, STZ-induced diabetes); long-term study; pumps replaced at two week intervals; ALZET brain infusion kit used; post op. care (Buprenorphine); cannula placement verified by injecting 20 ul dye through the catheter at time of assay.

P9034 Belmadani,S., Zerfaoui,M., Boulares,H.A., Palen,D.I., Matrougui,K. Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alpha v beta3-integrin, and TGF-beta 1 in response to ANG II and high glucose. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-1-):H69-H76. >>> Angiotensin II; SC; Mice; 2004; 4 weeks; Controls were sham operated; peptides; animal info (C57BL6/J); STZ induced diabetes.

P8910 do Carmo,J.M., Hall,J.E., da Silva,A.A. Chronic central leptin infusion restores cardiac sympathetic-vagal balance and baroreflex sensitivity in diabetic rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-5-):H1974-H1981. >>> Leptin; CSF/CNS; Rat; 1007D; 7 days; Peptides; animal info (male, Sprague Dawley, 340-360 g.); tygon tubing used; diabetes.

P8792 Ferron,M., Hinoi,E., Karsenty,G., Ducy,P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-13-):5266-5270. >>> Osteocalcin; SC; Mice; 28 days; Controls received mp w/ vehicle; dose-response (fig 2, pg. 5268); animal info (C57BL/6J); obesity; "all of these results were obtained through continuous delivery of osteocalcin." (pg. 5269); diabetes.

P8782 Giraud,S., Barrou,B., Sebillaud,S., Debre,P., Klatzmann,D., Thomas-Vaslin,V. Transient depletion of dividing T lymphocytes in mice induces the emergence of regulatory T cells and dominant tolerance to islet allografts. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-5-):942-953. >>> Ganciclovir; Water, pyrogen-free; SC; Mice; mice (transgenic); 2001; 2002; 7, 14 days; STZ-induced diabetes, animal info (FVB EpCD4TK, FVB/N, B6 islet allograft, skin allograft).

R0254 Hasko,G., Pacher,P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. Journal of Leukocyte Biology 2008; 83(-3-):447-455. >>> ATL146c; Rat; mice; rabbit; ; Replacement therapy (STZ-induced diabetes); ischemia (renal, hepatic); review, see ref #'s 79, 90, 91, 92, 93, 95.

P8936 Kobayashi,T., Nogami,T., Taguchi,K., Matsumoto,T., Kamata,K. Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK. British Journal of Pharmacology 2008; 155(-7-):974-983. >>> Angiotensin II; SC; Rat; 2ML2; 2 weeks; Controls were not diabetic; peptides; animal info (male, Wistar, 17 wks old); STZ-induced diabetes.

P8868 Mziaut,H., Kersting,S., Knoch,K.P., Fan,W.H., Trajkovski,M., Erdmann,K., Bergert,H., Ehehalt,F., Saeger,H.D., Solimena,M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-2-):674-679. >>> Uridine, bromodeoxy-; DMSO; IP; Mice; 1007D; 7 days; Animal info (ICA 512 -/-); 50% DMSO used; diabetes.

P9197 Palen,D.I., Matrougui,K. Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice. DIABETES-METABOLISM RESEARCH AND REVIEWS 2008; 24(-8-):651-656. >>> AG-1478; Mice; 2 weeks; Animal info (type 2 diabetic, non diabetic, male, 12-14 wks old); AG-1478 is an epidermal growth factor receptor (EGFR) inhibitor; diabetes.

P8789 Park,K., Itoh,H., Yamahara,K., Sone,M., Miyashita,K., Oyamada,N., Sawada,N., Taura,D., Inuzuka,M., Sonoyama,T., Tsujimoto,H., Fukunaga,Y., Tamura,N., Nakao,K. Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases. Endocrinology 2008; 149(-2-):483-491. >>> Carperitide; Water; IP; Mice; 1002; 28 days; Controls received mp w/ vehicle; STZ-induced Diabetes; pumps replaced after 14 days; ischemia (hind limb); animal info (male, C57BL/6, 8 wks old, femoral artery ligation); Carperitide is a recomb. human ANP.

Q0808 Poornima,I., Brown,S.B., Bhashyam,S., Parikh,P., Bolukoglu,H., Shannon,R.P. Chronic Glucagon-Like Peptide-1 Infusion Sustains Left Ventricular Systolic Function and Prolongs Survival in the Spontaneously Hypertensive, Heart Failure-Prone Rat. Circulation-Heart Failure 2008; 1(-3-):153-160. >>> Glucagon-like peptide-1; Rat; ; Controls received mp w/ saline; animal info (9 mo old, SHHF); long-term study; pumps replaced every 21 days; obesity; diabetes.

P9376 Rodriguez,W.E., Sen,U., Tyagi,N., Kumar,M., Carneal,G., Aggrawal,D., Newsome,J., Tyagi,S.C. PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice. International Journal of Biological Sciences 2008; 4(-4-):236-244. >>> FITC-Insulin; IP; Mice; 2001D; 24 hours; Replacement therapy (Alloxan-induced diabetes); cardiovascular; animal info (male, C57BL/6J); endocrinology.

P8507 Stranahan,A.M., Arumugam,T.V., Cutler,R.G., Lee,K., Egan,J.M., Mattson,M.P. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat.Neurosci. 2008/3; 11(-3-):309-317. >>> Ara-C; CSF/CNS; Mice; 1002; ; Diabetes; animal info (2 months old, wild-type); Ara-C is an anti-mitotic drug.

P9611 Takimoto,C., Kumagai,H., Osaka,M., Sakata,K., Onami,T., Kamayachi,T., Iigaya,K., Hayashi,K., Saruta,T., Itoh,H. Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats. HYPERTENSION RESEARCH 2008; 31(-10-):1941-1951. >>> Insulin; SC; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, 13 wks old, SHR); replacement therapy (STZ-induced Diabetes).

P8758 Warne,J.P., Foster,M.T., Horneman,H.F., Pecoraro,N.C., de Jong,H.K., Ginsberg,A.B., Akana,S.F., Dallman,M.F. The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 294(-1-):E190-E200. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced Diabetes, gastroduodenal branch vagotomy).

P8381 Almind,K., Manieri,M., Sivitz,W.I., Cinti,S., Kahn,C.R. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-7-):2366-2371. >>> CL-316, 243; SC; Mice; 7 days; Controls received mp w/ saline; animal info (male, C57BL/6, 12956/SvEv Tac, 10 wks old); B3-adrenergic agonist; diabetes.

P8167 Bidani,A.K., Picken,M., Hacioglu,R., Williamson,G., Griffin,K.A. Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance. American Journal of Physiology-Renal Physiology 2007; 292(-2-):F647-F654. >>> Insulin; SC; Rat; 16-20, 36-40 weeks; Replacement therapy (STZ-induced Diabetes); long-term study; pumps replaced every 4 weeks; peptides; animal info (male, Sprague-Dawley, 8 weeks old, 250 grams).

P8361 Gangula,P.R.R., Maner,W.L., Micci,M.A., Garfield,R.E., Pasricha,P.J. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. American Journal of Physiology-Gastrointestinal and Liver Physiology 2007; 292(-3-):G725-G733. >>> L-NAME; SC; Rat; 2ML1; 4 days; Replacement therapy (STZ-induced diabetes mellitus; enzyme inhibitor (nitric oxide synthase); animal info (male, female, Sprague-Dawley, 7 wks old).

P7969 Garcia-Vicente,S., Yraola,F., Marti,L., Gonzalez-Munoz,E., Garcia-Barrado,M.J., Canto,C., Abella,A., Bour,S., Artuch,R., Sierra,C., Brandi,N., Carpene,C., Moratinos,J., Camps,M., Palacin,M., Testar,X., Guma,A., Albericio,F., Royo,M., Mian,A., Zorzano,A. Oral insulin-mimetic compounds that act independently of insulin. Diabetes 2007; 56(-2-):486-493. >>> B6V10; decavanadate; SC; Rat; 12 days; Animal info (male, Wistar, 180-220 grams); diabetes.

P8128 Hartner,A., Cordasic,N., Klanke,B., Wittmann,M., Veelken,R., Hilgers,K.F. Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. American Journal of Physiology-Renal Physiology 2007; 292(-2-):F820-F827. >>> Losartan; IP; Rat; rat (transgenic); 2004; 4 weeks; Controls received mp w/ saline; replacement therapy (STZ-induced diabetes mellitus); animal info (male, Sprague-Dawley-Hanover, ren-2 Tg, 12 wks old, 250g.).

P8749 Ihara,Y., Egashira,K., Nakano,K., Ohtani,K., Kubo,M., Koga,J.I., Iwai,M., Horiuchi,M., Gang,Z., Yamagishi,S.I., Sunagawa,K. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):455-464. >>> Angiotensin II; Mice; 1 week; Cardiovascular; peptides; animal info (male, ApoE -/-, 15-16 weeks old, 25g); diabetes.

P8149 Kovacs,P., Morales,J.C., Karkanias,G.B. The effect of diabetes and centrally administered insulin on anterior hypothalamic estrogen receptor alpha immunoreactivity. ACTA DIABETOLOGICA 2007; 44(-1-):38-44. >>> Insulin, human; Saline; CSF/CNS (third ventricle); Rat; 2002; 14 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced Diabetes, ovariectomy); peptides; animal info (female, Sprague-Dawley, 175-200g.); tissue perfusion (ventricle).

P8713 Kusari,J., Zhou,S., Padillo,E., Clarke,K.G., Gil,D.W. Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2007; 48(-11-):5152-5159. >>> Memantine; Water, distilled; SC; Rat; 2ML2; 3-4 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma MEM levels; pumps replaced after 2 weeks; animal info (male, Brown Norway, 250-300g); diabetes.

P8989 Nagai,N., Izumi-Nagai,K., Oike,Y., Koto,T., Satofuka,S., Ozawa,Y., Yamashiro,K., Inoue,M., Tsubota,K., Umezawa,K., Ishida,S. Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappa B pathway. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2007; 48(-9-):4342-4350. >>> PD123319; PBS; DMSO; SC; Mice; 2001; 1 week; Controls received vehicle; replacement therapy (STZ-induced diabetes); dose-response (fig. 2); no stress (see pg. 4344); animal info (male, C57BL/6, 6-8 wks old); 0.25% DMSO used; AT2-Rblocker.

P8310 Singh,A.K., Gudehithlu,K.P., Litbarg,N.O., Sethupathi,P., Arruda,J.A.L., Dunea,G. Transplanting fragments of diabetic pancreas into activated omentum gives rise to new insulin producing cells. Biochemical and Biophysical Research Communications 2007; 355(-1-):258-262. >>> Insulin; SC; Rat; 28 days; Replacement therapy (STZ-induced diabetes, pancreatectomy and autotransplanted into omentum; immunology; animal info (male, Sprague-Dawley, 150-200g.); nephrology.

P8046 Taguchi,K., Kobayashi,T., Hayashi,Y., Matsumoto,T., Kamata,K. Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta. European Journal of Pharmacology 2007; 556(-1-3-):121-128. >>> Angiotensin II; Saline; Rat; 2ML2; 1 week; Plasma levels and blood pressure measured; cardiovascular; peptides; animal info (diabetic, male, Wistar, 8 weeks old, 200-230 grams); diabetes.

P8642 Takahashi,H., Ichihara,A., Kaneshiro,Y., Inomata,K., Sakoda,M., Takemitsu,T., Nishiyama,A., Itoh,H. Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. Journal of the American Society of Nephrology 2007; 18(-7-):2054-2061. >>> Prorenin, receptor blocker; peptide, M30TRISAE36; SC; Rat; 2004; 12 weeks; Controls received mp w/ vehicle peptide M30TRISAE36; replacement therapy (heminephrectomy, STZ-induced diabetes); long-term study; pumps replaced every 28 days; peptides; animal info (male, Sprague-Dawley, 17 wks old).

P8292 van den Hoek,A.M., Heijboer,A.C., Voshol,P.J., Havekes,L.M., Romijn,J.A., Corssmit,E.P.M., Pijl,H. Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 292(-1-):E238-E245. >>> Peptide YY (3-36); Saline; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; plasma levels taken; comparison of bolus injection vs. mp; animal info (C57BL/6, male, 3 months old, 35 grams); diabetes; gut hormone.

P8620 Warne,J.P., Foster,M.T., Horneman,H.E., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats. JOURNAL OF PHYSIOLOGY-LONDON 2007; 583(-2-):455-467. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced diabetes); peptides; animal info (male, Sprague-Dawley, 300 g); catheter position verified.

P8701 Warne,J.P., Horneman,H.F., Ginsberg,A.B., Pecoraro,N.C., Foster,M.T., Akana,S.F., Dallman,M.F. Mapping brain c-fos immunoreactivity after insulin-induced voluntary lard intake: Insulin- and lard-associated patterns. Journal of Neuroendocrinology 2007; 19(-10-):794-808. >>> Insulin, Humulin R U500; Saline; IV (jugular); Rat; 2002; 10 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced diabetes); no stress (see pg. 797); peptides; post op. care (Ketoprofen); animal info (male, Sprague-Dawley, 300g); "The presence of an osmotic mini-pump at either site did not cause any obvious signs of pains or discomfort in the rats. " (p. 797).

P8567 Zhang,J., Tokui,Y., Yamagata,K., Kozawa,J., Sayama,K., Iwahashi,H., Okita,K., Miuchi,M., Konya,H., Hamaguchi,T., Namba,M., Shimomura,I., Miyagawa,J.I. Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes. Diabetologia 2007; 50(-9-):1900-1909. >>> Glucagon-like peptide-1; Acetic acid buffer, 5%; SC; Mice; 2004; 4 or 8 weeks; Controls received mp w/ saline; functionality of mp verified by GLP-1 plasma levels; long-term study; pumps replaced after 4 weeks; animal info (female, NOD mice, 8 weeks old); diabetes; "plasma concentrations of active GLP-1...after pump implantation were significantly elevated and about 1.5 fold higher than before the pump implantation. We therefore considered this delivery system to be appropriate for this experiment." (p. 1903).

P8465 Zhou,L., Sutton,G.M., Rochford,J.J., Semple,R.K., Lam,D.D., Oksanen,L.J., Thornton-Jones,Z.D., Clifton,P.G., Yueh,C.Y., Evans,M.L., McCrimmon,R.J., Elmquist,J.K., Butler,A.A., Heisler,L.K. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metabolism 2007; 6(-5-):398-405. >>> MCPP; BVT.X; Saline; SC; Mice; mice (knockout); 7,14 days; Controls received mp w/ vehicle; comparison of IP injections vs. SC mp; diabetes; animal info (diet-induced obese male); Research Diets; 5-HT agonist.

P7754 Awad,A.S., Huang,L.P., Ye,H., Duong,E.T.A., Bolton,W.K., Linden,J., Okusa,M.D. Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy. American Journal of Physiology-Renal Physiology 2006; 290(-4-):F828-F837. >>> ATL146e; ATL313; PBS; DMSO; SC; Rat; mice; 2004; 4,5,6 weeks; Controls received mp w/ vehicle; no stress (see pg. F830); half-life (p. F831) ATL313 has a longer half-life than ATL1466; animal info (Sprague-Dawley, 14 wk old, 245-255g.; C57BL/6, 7-8 wk. old, A2A-KO/C57BL/6, 20g.); STZ induced diabetes.

P8217 Castellano,J.M., Navarro,V.M., Fernandez-Fernandez,R., Roa,J., Vigo,E., Pineda,R., Dieguez,C., Aguilar,E., Pinilla,L., Tena-Sempere,M. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006; 55(-9-):2602-2610. >>> Insulin; leptin; Saline; HCI; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle, or nondiabetic; replacement therapy (STZ-induced Diabetes); peptides; animal info (male, Wistar, adult).

P8229 Chen,P., Scicli,G.M., Guo,M., Fenstermacher,J.D., Dahl,D., Edwards,P.A., Scicli,A.G. Role of angiotensin II in retinal leukostasis in the diabetic rat. Experimental Eye Research 2006; 83(-5-):1041-1051. >>> Losartan; IP; Rat; 2 weeks; Controls received no treatment; replacement therapy (STZ-induced diabetes); animal info (male, Long-Evans, 200-225 grams); Ang II-AT1 receptor antagonist.

P8358 Klein,J.D., Kozlowski,S., Antoun,T.A., Sands,J.M. Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney. Journal of Membrane Biology 2006; 212(-2-):139-144. >>> Aldosterone; Rat; 14 days; Replacement therapy (adrenalectomy, STZ-induced diabetes mellitus); animal info (male, Sprague-Dawley, 100-150 grams); endocrinology.

P9141 Seigel,G.M., Lupien,S.B., Campbell,L.A., Ishii,D.N. Systemic IGF-I treatment inhibits cell death in diabetic rat retina. Journal of Diabetes and Its Complications 2006; 20(-3-):196-204. >>> Insulin-like growth factor I; streptozotocin; Acetate; SC; Rat; 2002; 8 weeks; Controls received mp w/ vehicle; long-term study; animal info (Wistar, 12 wks old); diabetes.

P7829 Toth,C., Brussee,V., Zochodne,D.W. Remote neurotrophic support of epidermal nerve fibres in experimental diabetes. Diabetologia 2006; 49(-5-):1081-1088. >>> Insulin; insulin-like growth factor-1; Saline; SC; CSF/CNS (intrathecal, lumbar); Rat; 2002; 1 month; Controls received mp w/ vehicle; replacement therapy (stz-induced diabetes); pumps replaced after 2 weeks; peptides; animal info (male, Sprague-Dawley, 300-350g.); comparison of SC mp vs. IT mp.

P7985 Warne,J.P., Horneman,H.F., Wick,E.C., Bhargava,A., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores. Endocrinology 2006; 147(-11-):5443-5451. >>> Insulin, methylene blue; Saline; IV (jugular); Rat; 2002; ; Functionality of mp verified by dye infusion; replacement therapy (diabetic); no stress (see pg. 5444); good methods; peptides; animal info (male, Sprague-Dawley, 275 grams); diabetes; PE-60 fused to PE-5.

P8042 Wente,W., Efanov,A.M., Brenner,M., Kharitonenkov,A., Koester,A., Sandusky,G.E., Sewing,S., Treinies,I., Zitzer,H., Gromada,J. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 2006; 55(-9-):2470-2478. >>> Fibroblast growth factor-21; Saline; SC; Mice; 1002; 8 weeks; FGF-21 plasma levels taken; long-term study; pumps replaced every two weeks; animal info (C57BL/6, 8 weeks old); diabetes.

P8033 Xu,J., Gowen,L., Raphalides,C., Royer,K.K., Weinger,J.G., Renard,M., Troke,J.J., Vaitheesyaran,B., Lee,W.N.P., Saad,M.F., Sleeman,M.W., Teitell,M.A., Kurland,I.J. Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse. Diabetes 2006; 55(-12-):3372-3380. >>> Glucose; glycerol; Radio-isotopes; 13C tracer; 13C6 tracer; SC; Mice; 2001D; 24 hours; Plasma levels; animal info (14-18 weeks, 24-27 grams, male and female); diabetes; glycerol labeled with 13C.

P8034 Xu,J., Lee,W.N.P., Phan,J., Saad,M.F., Reue,K., Kurland,I.J. Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes 2006; 55(-12-):3429-3438. >>> Lactate; glucose; Water; radio-isotopes; 13C tracer; SC; Mice; 2001D; 24 hours; Plasma levels taken; animal info (Balb/cByJ, 7-9 months old, 28 grams); anesthesia and implantation was<3 min/mouse; diabetes.

P7773 Yang,Z.D., Chen,M., Carter,J.D., Nunemaker,C.S., Garmey,J.C., Kimble,S.D., Nadler,J.L. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochemical and Biophysical Research Communications 2006; 344(-3-):1017-1022. >>> Lisofylline; exendin-4; Saline; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; replacement therapy (non-obese diabetes); animal info (C57BL/6J, NOD/LtJ, 18-30 wk. old).

P7720 Zelena,D., Mergl,Z., Makara,G.B. The role of vasopressin in diabetes mellitus-induced hypothalamo-pituitary-adrenal axis activation: Studies in Brattleboro rats. Brain Research Bulletin 2006; 69(-1-):48-56. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; 18 days; Controls received sham surgery; pumps replaced after 10 days; animal info (male, brattleboro, di/di, di/+); v2 agonist; diabetes; A.K.A dDavp or Desmopressin or desmopresinum.

P7834 Zimanyi,M.A., Denton,K.M., Forbes,J.M., Thallas-Bonke,V., Thomas,M.C., Poon,F., Black,M.J. A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products. Diabetologia 2006; 49(-4-):801-810. >>> BSA, AGE-modified; BSA; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; no stress (see pg. 804); animal info (male, Wistar-Kyoto, 20-24 wk. old); AGES (advanced gylcation end-products); comparable w/ advanced diabetes.

P7673 Dragonas,C., Mueller,A., Maltaris,T., Kraemer,P., Dimmler,A., Jaeger,W., Beckmann,M.W., Dittrich,R. Role of insulin in the progression of ovarian sex cord stromal tumors in rats. Journal of Cancer Research and Clinical Oncology 2005; 131(-11-):751-757. >>> Insulin; SC; Rat; 28, 56, 84 days; Controls received mp w/ saline; replacement therapy (ovariectomy, STZ-induced diabetes); long-term study; pumps replaced every 28 days; no stress (see pg.753); cancer (sex cord stomal); animal info (female, Lewis, 60 days old, 150-210 g).

P6956 El Midaoui,A., De Champlain,J. Effects of glucose and insulin on the development of oxidative stress and hypertension in animal models of type 1 and type 2 diabetes. Journal of Hypertension 2005; 23(-3-):581-588. >>> Insulin; Saline; glutamic acid; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; insulin plasma levels taken; cardiovascular; peptides; diabetes; 0.7% glutamic acid added to prevent insulin aggregation; replacement therapy (STZ-induced Diabetes).

P7358 El Midaoui,A., Ongali,B., Petcu,M., Rodi,D., De Champlain,J., Neugebauer,W., Couture,R. Increases of spinal kinin receptor binding sites in two rat models of insulin resistance. Peptides 2005; 26(-8-):1323-1330. >>> Insulin; SC; Rat; 2002; 2 weeks; Peptides; diabetes.

P6949 Fowler,M., Virostko,J., Chen,Z.Y., Poffenberger,G., Radhika,A., Brissova,M., Shiota,M., Nicholson,W.E., Shi,Y.B., Hirshberg,B., Harlan,D.M., Jansen,E.D., Powers,A.C. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation 2005; 79(-7-):768-776. >>> Insulin, human; SC; Mice (SCID); 1002; 7,10 days; Diabetes; bioluminescence imaging (BLI); IVIS 200 system used after pumps were removed.

P7672 Gorin,Y., Block,K., Hernandez,J., Bhandari,B., Wagner,B., Barnes,J.L., Abboud,H.E. Nox4 NAD(P) H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. Journal of Biological Chemistry 2005; 280(-47-):39616-39626. >>> Oligonucleotide, phosphorothioate antisense; oligonucleotide, phosphorothioate sense; SC; Rat; 2 weeks; Controls received mp w/ sense oligo or not treatment; functionality of mp verified by Nox4 levels in kidney cortex; replacement therapy (STZ-induced diabetes); anti-sense (Nox4); animal info (male, Sprague-Dawley, 200-225 g).

P7564 Ichinose,K., Maeshima,Y., Yamamoto,Y., Kitayama,H., Takazawa,Y., Hirokoshi,K., Sugiyama,H., Yamasaki,Y., Eguchi,K., Makino,H. Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model. Diabetes 2005; 54(-10-):2891-2903. >>> Endostatin, human (1-27); PBS; SC; Mice; 2004; 2 weeks; Controls received mp w/ vehicle; replacement therapy (STZ diabetes); dose-response (fig. 2); no stress (see pg.2892); peptides; animal info (female, C57BL/6, 21-26 g).

P7660 Knauf,C., Cani,P.D., Perrin,C., Iglesias,M.A., Maury,J.F., Bernard,E., Benhamed,F., Gremeaux,T., Drucker,D.J., Kahn,C.R., Girard,J., Tanti,J.F., Delzenne,N.M., Postic,C., Burcelin,R. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. Journal of Clinical Investigation 2005; 115(-12-):3554-3563. >>> Exendin (9-39); IP; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (diet-induced diabetes); Alzet brain infusion kit used; animal info (C57BL/6J, male, 12 week old); BIK used with other apparatus for short term icv infusion.

P6969 Samnegard,B., Jacobson,S.H., Jaremko,G., Johansson,B.L., Ekberg,K., Isaksson,B., Eriksson,L., Wahren,J., Sjoequist,M. C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. NEPHROLOGY DIALYSIS TRANSPLANTATION 2005; 20(-3-):532-538. >>> C-peptide; Saline; SC; Rat; 2002; 4 weeks; Peptides; diabetes.

P7756 Shibuya,K., Kanasaki,K., Isono,M., Sato,H., Omata,M., Sugimoto,T., Araki,S.I., Isshiki,K., Kashiwagi,A., Haneda,M., Koya,D. N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice. Diabetes 2005; 54(-3-):838-845. >>> Peptide, Ac-SDKP; Balanced salt solution; SC; Mice; 2004; 8 weeks; Controls received mp w/ vehicle, or controll peptide; functionality of mp verified by plasma AC-SDKP levels; replacement therapy (diabetes); long-term study; pumps replaced at 4 weeks; no stress (see pg. 839, 843); peptides; animal info (male, db/db, db/m, 10 wk. old).

P7526 Toyoshima,Y., Gavrilova,O., Yakar,S., Jou,W., Pack,S., Asghar,Z., Wheeler,M.B., LeRoith,D. Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology 2005; 146(-9-):4024-4035. >>> Leptin; SC; Mice; 2002; 14 days; Controls received mp w/ saline; functionality of mp verified by serum leptin levels; replacement therapy (type 2 diabetes); peptides; animal info (MKR male, 6-7 wk. old, wild type 20-25 g).

P7512 Visentin,V., Bour,S., Boucher,M., Prevot,D., Valet,P., Ordener,C., Parini,A., Carpene,C. Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide. European Journal of Pharmacology 2005; 522(-1-3-):139-146. >>> Tyramine; tyramine, 14C-; SC; Rat; 3 weeks; Controls received no treatment, normoglycemic; replacement therapy (STZ-induced diabetes); pumps replaced at 2 weeks; animal info (male, wistar, 7 wk old); amine oxidase substrate.

P7093 Akirav,E.M., Chan,O., Inouye,K., Riddell,M.C., Matthews,S.G., Vranic,M. Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats. METABOLISM-CLINICAL AND EXPERIMENTAL 2004; 53(-12-):1558-1564. >>> Leptin, recomb. mouse; PBS; SC; Rat; 4 days; Controls received mp w/ vehicle; replacement therapy (STZ-diabetes); peptides; STZ induced diabetes.

P7088 Aubel,B., Kayser,V., Mauborgne,A., Farre,A., Hamon,M., Bourgoin,S. Antihyperalgesic effects of cizolirtine in diabetic rats: Behavioral and biochemical studies. Pain 2004; 110(-1-2-):22-32. >>> Cizolirtine; paroxetine hydrochloride; Saline; DMSO; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; replacement therapy (STZ-induced diabetes); dose-response (fig. 4); 20% DMSO.

P6798 Brussee,V., Cunningham,F.A., Zochodne,D.W. Direct insulin signaling of neurons reverses diabetic neuropathy. Diabetes 2004; 53(-7-):1824-1830. >>> Insulin, human; FITC-Insulin; Insulin-like growth factor I; antibody, polyclonal anti-rat insulin; dye, india ink; antibody, polyclonal anti-albumin; Saline; SC; CSF/CNS (intrathecal); Rat; 2, 4 weeks; Controls received mp w/ vehicle or anti-albumin Ab; functionality of mp verified by dye; replacement therapy (streptozotocin induced diabetes); india ink used to confirm catheter placement and intrathecal delivery.

P6453 Cui,Y.X., Huang,L., Elefteriou,F., Yang,G.Q., Shelton,J.M., Giles,J.E., Oz,O.K., Pourbahrami,T., Lu,C.Y.H., Richardson,J.A., Karsenty,G., Li,C. Essential role of STAT3 in body weight and glucose homeostasis. MOLECULAR AND CELLULAR BIOLOGY 2004; 24(-1-):258-269. >>> Leptin, recomb. human; Saline; CSF/CNS (third ventricle); Mice (knockout, transgenic); 2004; 28 days; ALZET brain infusion kit 2; peptides; obesity; diabetes.

P6810 Delporte,M.L., El Mkadem,S.A., Quisquater,M., Brichard,S.M. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004; 287(-3-):E446-E453. >>> Leptin, recomb. mouse; Sodium citrate; SC; Mice; 2001; 3, 6 days; Controls received mp w/ vehicle; replacement therapy (obese (ob/ob) mice); peptides; obesity; diabetes.

P6395 Dunn,S.R., Qi,Z.H., Bottinger,E.P., Breyer,M.D., Sharma,K. Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney International 2004; 65(-5-):1959-1967. >>> FITC-inulin; Sodium chloride; IP; Mice; 1007D; ; FITC-inulin plasma levels taken; multiple pumps per animal (2); solution was filtered during pump filling; diabetes.

P6742 Ichihara,A., Hayashi,M., Kaneshiro,Y., Suzuki,F., Nakagawa,T., Tada,Y., Koura,Y., Nishiyama,A., Okada,H., Uddin,M.N., Nabi,A.H.M.N., Ishida,Y., Inagami,T., Saruta,T. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle'' region for nonproteolytic activation of prorenin. Journal of Clinical Investigation 2004; 114(-8-):1128-1135. >>> Peptide, prorenin handle region; SC; Rat; 2004; 8, 16, 24 weeks; Controls received mp w/ saline; long-term study; pumps replaced every 28 days; no stress (see pg.1129); enzyme inhibitor (prorenin); peptides; "Continuous infusion of HRP by subcutaneous minipumps did not affect the body weight, BP, or blood glucose levels of either control or diabetic rats during the 24-week treatment period." (p.1129); diabetes.

P6383 Kim,D.G., Sands,J.M., Klein,J.D. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F760-F766. >>> Vasopressin; Saline; SC; Rat; 2002; 5,12 days; Functionality of mp verified by urine osmolality; diabetes.

P6449 Kusaka,I., Kusaka,G., Zhou,C., Ishikawa,M., Nanda,A., Granger,D.N., Zhang,J.H., Tang,J.P. Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. American Journal of Physiology-Heart and Circulatory Physiology 2004; 286(-6-):H2442-H2451. >>> Candesartan; SC; Rat; 14 days; Ischemia (cerebral); diabetes; no side effects of minipump placement were noticed; pump model not listed; MCAO.

P6912 Lee,F.T.H., Cao,Z.M., Long,D.M., Panagiotopoulos,S., Jerums,G., Cooper,M.E., Forbes,J.M. Interactions between angiotensin II and NF-kappa B dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. Journal of the American Society of Nephrology 2004; 15(-8-):2139-2151. >>> PDTC; PD123319; SC; Rat; 2ML4; 4 weeks; Diabetes; PDTC is (Pyrrolidine dithiocarbamate).

P6794 Pittner,R.A., Moore,C.X., Bhavsar,S.P., Gedulin,B.R., Smith,P.A., Jodka,C.M., Parkes,D.G., Paterniti,J.R., Srivastava,V.P., Young,A.A. Effects of PYY[3-36] in rodent models of diabetes and obesity. International Journal of Obesity 2004; 28(-8-):963-971. >>> Peptide YY (3-36); PBS; SC; Rat; mice; 2004; 2ML4; 4, 8 weeks; Controls received mp w/ vehicle; dose-response (fig. 1); comparison of IP injections vs. mp; long-term study; pumps replaced after 4 weeks; diabetes; obesity; peptide.

P6915 Poulaki,V., Joussen,A.M., Mitsiades,N., Mitsiades,C.S., Iliaki,E.F., Adamis,A.P. Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy. American Journal of Pathology 2004; 165(-2-):457-469. >>> Wortmannin; ly294002; antibody, monoclonal aLR-3; SP600125; SN50; geldanamycin; IP; Rat; 2002; 7 days; Enzyme inhibitor (P1-3K, JNK); diabetes.

P6695 Qi,Z.H., Whitt,I., Mehta,A., Jin,J.P., Zhao,M., Harris,R.C., Fogo,A.B., Breyer,M.D. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. American Journal of Physiology-Renal Physiology 2004; 286(-3-):F590-F596. >>> FITC-inulin; Saline; IP; Mice; 1007D; 7 days; Functionality of mp verified by FITC-inulin plasma levels takenl; comparison of bolus injections vs. IP mp; good methods p. F591; multiple pumps per animal (2); diabetes; in detail solubilization methods; "using two pumps, a plasma fluorescence level two to six times higher than background was achieved." p.F591.

P6421 Ruzicska,E., Foldes,G., Lako-Futo,Z., Sarman,B., Wellmann,J., Szenasi,G., Tulassay,Z., Ruskoaho,H., Toth,M., Somogyi,A. Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overload. Journal of Hypertension 2004; 22(-6-):1191-1200. >>> Angiotensin II; SC; Rat; 24 hours; Blood pressure taken; cardiovascular; peptides; diabetes; 1 ul/hr pump used (model not listed).

P6762 Suganami,T., Mukoyama,M., Mori,K., Yokoi,H., Koshikawa,M., Sawai,K., Hidaka,S., Ebihara,K., Tanaka,T., Sugawara,A., Kawachi,H., Vinson,C., Ogawa,Y., Nakao,K. Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy. FASEB Journal 2004; 18(-13-):U261-U283. >>> Leptin, recomb. mouse; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by serum leptin concentrations; peptides; diabetes.

P6669 Tamarat,R., Silvestre,J.S., Ricousse-Roussanne,S., Barateau,V., Lecomte-Raclet,L., Clergue,M., Duriez,M., Tobelem,G., Levy,B.I. Impairment in ischemia-induced neovascularization in diabetes - Bone marrow mononuclear cell dysfunction and therapeutic potential of placenta growth factor treatment. American Journal of Pathology 2004; 164(-2-):457-466. >>> Placental growth factor; SC; Mice; 2001; 14 days; Diabetes, placenta growth factor (PIGF) is a VEGF homologue; ischemia.

P6461 Zhang,X.L., Lassila,M., Cooper,M.E., Cao,Z.M. Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors. Hypertension 2004; 43(-2-):276-281. >>> Angiotensin II; PD123319; Sodium chloride; acetic acid; SC; Rat; 2002; 2004; 2,4 weeks; Controls received mp w/ vehicle; STZ induced diabetes; multiple pumps per animal (2).

P5688 Abella,A., Marti,L., Camps,M., Claret,M., Fernandez-Alvarez,J., Gomis,R., Guma,A., Viguerie,N., Carpene,C., Palacin,M., Testar,X., Zorzano,A. Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. Diabetes 2003; 52(-4-):1004-1013. >>> Benzylamine hydrochloride; SC; Rat; 2 weeks; 2-week stability verified by in vitro glucose transport assay; diabetes..

P6082 Hayashi,T., Sohmiya,K., Ukimura,A., Endoh,S., Mori,T., Shimomura,H., Okabe,M., Terasaki,F., Kitaura,Y. Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart. HEART 2003; 89(-10-):1236-1242. >>> Candesartan; IP; Rat; 2002; 6 weeks; Long-term study; pumps replaced every two weeks; diabetes.

P6031 Kobayashi,T., Kaneda,A., Kamata,K. Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta. British Journal of Pharmacology 2003; 140(-2-):285-294. >>> Insulin; Saline; SC; Rat; 2ML2; 2 weeks; Insulin plasma levels taken; cardiovascular; peptides; diabetes; replacement therapy (STZ-induced Diabetes).

P6101 Lupien,S.B., Bluhm,E.J., Ishii,D.N. Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. Journal of Neuroscience Research 2003; 74(-4-):512-523. >>> Insulin-like growth factor; antiserum, human IGF II; serum, preimmune; Acetic acid; CSF, artificial; SC; CSF/CNS; Rat; 7.5 weeks; Pumps replaced every 19 days; ALZET brain infusion kit used; peptides; diabetes; IGF delivered SC and separate study for ICV infusion of anti-IGF-II antiserum or preimmune serum; (PIS) dissolved in aCSF; cannulae placement verified post experiment by bromophenol blue.

P6073 Miyanaga,F., Ogawa,Y., Ebihara,K., Hidaka,S., Tanaka,T., Hayashi,S., Masuzaki,H., Nakao,K. Leptin as an adjunct of insulin therapy in insulin-deficient diabetes. Diabetologia 2003; 46(-10-):1329-1337. >>> Leptin; insulin, human; Saline; SC; Mice (transgenic); 1007D; ; Controls received mp w/ vehicle; leptin plasma levels taken; peptides; paper incorrectly states pump model as a 1002D; replacement therapy (STZ-induced Diabetes).

P6015 Song,J., Knepper,M.A., Verbalis,J.G., Ecelbarger,C.A. Increased renal ENaC subunit and sodium transporter abundances in streptozotocin-induced type 1 diabetes. American Journal of Physiology-Renal Physiology 2003; 285(-6-):F1125-F1137. >>> Insulin; SC; Rat; 2002; 14 days; Insulin plasma levels taken; peptides; timeline of pump usage, p. F1127 (Fig. A); replacement therapy (STZ-induced Diabetes).

P5058 Gill,R., Nazir,T.M., Wali,R., Sitrin,M., Brasitus,T.A., Ramaswamy,K., Dudeja,P.K. Regulation of rat ileal NHE3 by 1,25(OH)(2)-vitamin D-3. Digestive Diseases and Sciences 2002; 47(-5-):1169-1174. >>> Vitamin D3, 1, 25-dihydroxy-; SC; rat; 2001; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum Vitamin D3 levels; streptozotocin induced diabetes, p. 1170.

P5114 Granda,T.G., Velasco,A. Effects of insulin administration in diabetic rats on food and drink rhythmic schedules. BIOLOGICAL RHYTHM RESEARCH 2002; 33(-1-):1-14. >>> Insulin; SC; rat; 2ML4; 4 weeks; controls received mp w/ vehicle; replacement therapy (STZ-induced Diabetes).

P5498 Granda,T.G., Velasco,A. Sodium and potassium clearance rhythmicity in diabetic rats with insulin treatment. LIFE SCIENCES 2002; 71(-21-):2475-2487. >>> Insulin; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; replacement therapy (streptozotocin-induced diabetes); peptides.

P4772 Fedele,M.J., Lang,C.H., Farrell,P.A. Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise. Am.J.Physiol.Endocrinol Metab. 2001; 280(--):E877-E885. >>> Antibody, anti-IGF-I polyclonal;; Saline;; SC;; rat;; 2ML1;; 7 days;; Controls received mp w/ non-specific Immunoglobulin G; functionality of mp verified by plasma levels; immunology; peptides; rats underwent partial pancreatetomy to create diabetic state; antibody delivered wan as anti-insulin-like growth factor I antibody; diabetes; pumps used for passive immunization against IGF-I; anti IGF-I antibody used is called SC-7144;.

P5766 Hidaka,S., Yoshimatsu,H., Kondou,S., Oka,K., Tsuruta,Y., Sakino,H., Itateyama,I., Noguchi,H., Himeno,K., Okamoto,K., Teshima,Y., Okeda,T., Sakata,T. Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats. J Neurochem 2001; 77(-4-):993-1000. >>> Insulin; Leptin; CSF/CNS (third ventricle); Rat; 2001; 6 days; Controls received mp w/ saline; peptides; leptin was recomb. murine; guide cannula w/ stylet used; replacement therapy (STZ-induced Diabetes).

P4906 Holness,M.J., Sugden,M.C. Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver. Endocrinology 2001; 142(-9-):3742-3748. >>> Dexamethasone; SC; rat (pregnant); 5 days; controls received sham surgery; administration of dexamethasone was from day 14 to day 19 of gestation; "priming" SC injection of dexamethasone given before pump implantation; insulin resistance, diabetes;.

P5011 Imai,S., Tezuka,H., Fujita,K. A factor of inducing IgE from a filarial parasite prevents insulin-dependent diabetes mellitus in nonobese diabetic mice. Biochemical and Biophysical Research Communications 2001; 286(--):1051-1058. >>> Antigen, recombinant Dirofilaria immitis-derived; PBS; SC; mice; ; controls received mp w/ vehicle; dose-response (fig. 3); IgE plasma levels; immunology; autoimmune diabetes; DiAg is a factor from Dirofilaria immitis that induces antigen non-specific IgE, suppresses anaphylaxis; IgE immune response to DiAg (p. 1054)..

P4980 Soriano,F.G., Pacher,P., Mabley,J., Liaudet,L., Szabo,C. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ.Res 2001/10/12; 89(-8-):684-691. >>> Insulin, bovine; SC; Mice; 2004; ; 1 or 4 weeks; replacement therapy (streptozotocin-induced diabetes); incorrectly states pump model was 1004.

P4829 Yuan,M, Konstantopoulos,N, Lee,J, Hansen,L, Li,Z.-W, Karin,M, Shoelson,S.E  Science 2001; 293(--):1673-1677. >>> Acetylsalicylic acid; salicylate, sodium; SC; Rat; mice; 2002; 2ML2; 3-4 weeks; Controls received mp w/ vehicle; 2ML2 used in rats, 2002 used in mice; acetylsalicylic acid also called aspirin: dose was 120 mg/kg/day; diabetes (type II).