References on Diabetes Research Using ALZET^® Osmotic Pumps

P9197 Palen,D.I., Matrougui,K. Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice. DIABETES-METABOLISM RESEARCH AND REVIEWS 2008; 24(-8-):651-656. >>> AG-1478; Mice; 2 weeks; Animal info (type 2 diabetic, non diabetic, male, 12-14 wks old); AG-1478 is an epidermal growth factor receptor (EGFR) inhibitor; diabetes.

P9141 Seigel,G.M., Lupien,S.B., Campbell,L.A., Ishii,D.N. Systemic IGF-I treatment inhibits cell death in diabetic rat retina. Journal of Diabetes and Its Complications 2006; 20(-3-):196-204. >>> Insulin-like growth factor-1; streptozotocin; Acetate; SC; Rat; 2002; 8 weeks; Controls received mp w/ vehicle; long-term study; animal info (Wistar, 12 wks old); diabetes.

P9034 Belmadani,S., Zerfaoui,M., Boulares,H.A., Palen,D.I., Matrougui,K. Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alpha v beta3-integrin, and TGF-beta 1 in response to ANG II and high glucose. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-1-):H69-H76. >>> Angiotensin II; SC; Mice; 2004; 4 weeks; Controls were sham operated; peptides; animal info (C57BL6/J); STZ induced diabetes.

P8989 Nagai,N., Izumi-Nagai,K., Oike,Y., Koto,T., Satofuka,S., Ozawa,Y., Yamashiro,K., Inoue,M., Tsubota,K., Umezawa,K., Ishida,S. Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappa B pathway. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2007; 48(-9-):4342-4350. >>> PD123319; PBS; DMSO; SC; Mice; 2001; 1 week; Controls received vehicle; replacement therapy (STZ-induced diabetes); dose-response (fig. 2); no stress (see pg. 4344); animal info (male, C57BL/6, 6-8 wks old); 0.25% DMSO used; AT2-Rblocker.

P8936 Kobayashi,T., Nogami,T., Taguchi,K., Matsumoto,T., Kamata,K. Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK. British Journal of Pharmacology 2008; 155(-7-):974-983. >>> Angiotensin II; SC; Rat; 2ML2; 2 weeks; Controls were not diabetic; peptides; animal info (male, Wistar, 17 wks old); STZ-induced diabetes.

P8910 do Carmo,J.M., Hall,J.E., da Silva,A.A. Chronic central leptin infusion restores cardiac sympathetic-vagal balance and baroreflex sensitivity in diabetic rats. American Journal of Physiology-Heart and Circulatory Physiology 2008; 295(-5-):H1974-H1981. >>> Leptin; CSF/CNS; Rat; 1007D; 7 days; Peptides; animal info (male, Sprague Dawley, 340-360 g.); tygon tubing used; diabetes.

P8868 Mziaut,H., Kersting,S., Knoch,K.P., Fan,W.H., Trajkovski,M., Erdmann,K., Bergert,H., Ehehalt,F., Saeger,H.D., Solimena,M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-2-):674-679. >>> Uridine, bromodeoxy-; DMSO; IP; Mice; 1007D; 7 days; Animal info (ICA 512 -/-); 50% DMSO used; diabetes.

P8792 Ferron,M., Hinoi,E., Karsenty,G., Ducy,P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-13-):5266-5270. >>> Osteocalcin; SC; Mice; 28 days; Controls received mp w/ vehicle; dose-response (fig 2, pg. 5268); animal info (C57BL/6J); obesity; "all of these results were obtained through continuous delivery of osteocalcin." (pg. 5269); diabetes.

P8789 Park,K., Itoh,H., Yamahara,K., Sone,M., Miyashita,K., Oyamada,N., Sawada,N., Taura,D., Inuzuka,M., Sonoyama,T., Tsujimoto,H., Fukunaga,Y., Tamura,N., Nakao,K. Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases. Endocrinology 2008; 149(-2-):483-491. >>> Carperitide; Water; IP; Mice; 1002; 28 days; Controls received mp w/ vehicle; STZ-induced Diabetes, put in comments; pumps replaced after 14 days; ischemia (hind limb); animal info (male, C57BL/6, 8 wks old, femoral artery ligation); Carperitide is a recomb. human ANP.

P8782 Giraud,S., Barrou,B., Sebillaud,S., Debre,P., Klatzmann,D., Thomas-Vaslin,V. Transient depletion of dividing T lymphocytes in mice induces the emergence of regulatory T cells and dominant tolerance to islet allografts. AMERICAN JOURNAL OF TRANSPLANTATION 2008; 8(-5-):942-953. >>> Ganciclovir; Water, pyrogen-free; SC; Mice; mice (transgenic); 2001; 2002; 7, 14 days; STZ-induced diabetes, animal info (FVB EpCD4TK, FVB/N, B6 islet allograft, skin allograft).

P8758 Warne,J.P., Foster,M.T., Horneman,H.F., Pecoraro,N.C., de Jong,H.K., Ginsberg,A.B., Akana,S.F., Dallman,M.F. The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 294(-1-):E190-E200. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced Diabetes, gastroduodenal branch vagotomy).

P8749 Ihara,Y., Egashira,K., Nakano,K., Ohtani,K., Kubo,M., Koga,J.I., Iwai,M., Horiuchi,M., Gang,Z., Yamagishi,S.I., Sunagawa,K. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):455-464. >>> Angiotensin II; Mice; 1 week; Cardiovascular; peptides; animal info (male, ApoE -/-, 15-16 weeks old, 25g); diabetes.

P8713 Kusari,J., Zhou,S., Padillo,E., Clarke,K.G., Gil,D.W. Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2007; 48(-11-):5152-5159. >>> Memantine; Water, distilled; SC; Rat; 2ML2; 3-4 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma MEM levels; pumps replaced after 2 weeks; animal info (male, Brown Norway, 250-300g); diabetes.

P8701 Warne,J.P., Horneman,H.F., Ginsberg,A.B., Pecoraro,N.C., Foster,M.T., Akana,S.F., Dallman,M.F. Mapping brain c-fos immunoreactivity after insulin-induced voluntary lard intake: Insulin- and lard-associated patterns. Journal of Neuroendocrinology 2007; 19(-10-):794-808. >>> Insulin, Humulin R U500; Saline; IV (jugular); Rat; 2002; 10 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced diabetes); no stress (see pg. 797); peptides; post op. care (Ketoprofen); animal info (male, Sprague-Dawley, 300g); "The presence of an osmotic mini-pump at either site did not cause any obvious signs of pains or discomfort in the rats. " (p. 797).

P8642 Takahashi,H., Ichihara,A., Kaneshiro,Y., Inomata,K., Sakoda,M., Takemitsu,T., Nishiyama,A., Itoh,H. Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. Journal of the American Society of Nephrology 2007; 18(-7-):2054-2061. >>> Prorenin, receptor blocker; peptide, M30TRISAE36; SC; Rat; 2004; 12 weeks; Controls received mp w/ vehicle peptide M30TRISAE36; replacement therapy (heminephrectomy, STZ-induced diabetes); long-term study; pumps replaced every 28 days; peptides; animal info (male, Sprague-Dawley, 17 wks old).

P8620 Warne,J.P., Foster,M.T., Horneman,H.E., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats. JOURNAL OF PHYSIOLOGY-LONDON 2007; 583(-2-):455-467. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced diabetes); peptides; animal info (male, Sprague-Dawley, 300 g); catheter position verified.

P8592 Scheiwiller,E., Guler,H.P., Merryweather,J., Scandella,C., Maerki,W., Zapf,J., Froesch,E.R. Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I. Nature 1986; 323(-6084-):169-171. >>> Insulin-like growth factor I, recomb. human; insulin; growth hormone, human; Saline; acetic acid; Rat; 2001; 6 days; Replacement therapy (STZ-induced diabetes); dose-response (fig. 1); peptides; animal info (male, Tif RAI, 120-130 grams); endocrinology.

P8567 Zhang,J., Tokui,Y., Yamagata,K., Kozawa,J., Sayama,K., Iwahashi,H., Okita,K., Miuchi,M., Konya,H., Hamaguchi,T., Namba,M., Shimomura,I., Miyagawa,J.I. Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes. Diabetologia 2007; 50(-9-):1900-1909. >>> Glucagon-like peptide-1; Acetic acid buffer, 5%; SC; Mice; 2004; 4 or 8 weeks; Controls received mp w/ saline; functionality of mp verified by GLP-1 plasma levels; long-term study; pumps replaced after 4 weeks; animal info (female, NOD mice, 8 weeks old); diabetes; "plasma concentrations of active GLP-1...after pump implantation were significantly elevated and about 1.5 fold higher than before the pump implantation. We therefore considered this delivery system to be appropriate for this experiment." (p. 1903).

P8507 Stranahan,A.M., Arumugam,T.V., Cutler,R.G., Lee,K., Egan,J.M., Mattson,M.P. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat.Neurosci. 2008/3; 11(-3-):309-317. >>> Ara-C; CSF/CNS; Mice; 1002; ; Diabetes; animal info (2 months old, wild-type); Ara-C is an anti-mitotic drug.

P8465 Zhou,L., Sutton,G.M., Rochford,J.J., Semple,R.K., Lam,D.D., Oksanen,L.J., Thornton-Jones,Z.D., Clifton,P.G., Yueh,C.Y., Evans,M.L., McCrimmon,R.J., Elmquist,J.K., Butler,A.A., Heisler,L.K. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metabolism 2007; 6(-5-):398-405. >>> MCPP; BVT.X; Saline; SC; Mice; mice (knockout); 7,14 days; Controls received mp w/ vehicle; comparison of IP injections vs. SC mp; diabetes; animal info (diet-induced obese male); Research Diets; 5-HT agonist.

P8381 Almind,K., Manieri,M., Sivitz,W.I., Cinti,S., Kahn,C.R. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-7-):2366-2371. >>> CL-316, 243; SC; Mice; 7 days; Controls received mp w/ saline; animal info (male, C57BL/6, 12956/SvEv Tac, 10 wks old); B3-adrenergic agonist; diabetes.

P8361 Gangula,P.R.R., Maner,W.L., Micci,M.A., Garfield,R.E., Pasricha,P.J. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. American Journal of Physiology-Gastrointestinal and Liver Physiology 2007; 292(-3-):G725-G733. >>> L-NAME; SC; Rat; 2ML1; 4 days; Replacement therapy (STZ-induced diabetes mellitus; enzyme inhibitor (nitric oxide synthase); animal info (male, female, Sprague-Dawley, 7 wks old).

P8358 Klein,J.D., Kozlowski,S., Antoun,T.A., Sands,J.M. Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney. Journal of Membrane Biology 2006; 212(-2-):139-144. >>> Aldosterone; Rat; 14 days; Replacement therapy (adrenalectomy, STZ-induced diabetes mellitus); animal info (male, Sprague-Dawley, 100-150 grams); endocrinology.

P8310 Singh,A.K., Gudehithlu,K.P., Litbarg,N.O., Sethupathi,P., Arruda,J.A.L., Dunea,G. Transplanting fragments of diabetic pancreas into activated omentum gives rise to new insulin producing cells. Biochemical and Biophysical Research Communications 2007; 355(-1-):258-262. >>> Insulin; SC; Rat; 28 days; Replacement therapy (STZ-induced diabetes, pancreatectomy and autotransplanted into omentum; immunology; animal info (male, Sprague-Dawley, 150-200g.); nephrology.

P8292 van den Hoek,A.M., Heijboer,A.C., Voshol,P.J., Havekes,L.M., Romijn,J.A., Corssmit,E.P.M., Pijl,H. Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 292(-1-):E238-E245. >>> Peptide YY (3-36); Saline; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; plasma levels taken; comparison of bolus injection vs. mp; animal info (C57BL/6, male, 3 months old, 35 grams); diabetes; gut hormone.

P8229 Chen,P., Scicli,G.M., Guo,M., Fenstermacher,J.D., Dahl,D., Edwards,P.A., Scicli,A.G. Role of angiotensin II in retinal leukostasis in the diabetic rat. Experimental Eye Research 2006; 83(-5-):1041-1051. >>> Losartan; IP; Rat; 2 weeks; Controls received no treatment; replacement therapy (STZ-induced diabetes); animal info (male, Long-Evans, 200-225 grams); Ang II-AT1 receptor antagonist.

P8217 Castellano,J.M., Navarro,V.M., Fernandez-Fernandez,R., Roa,J., Vigo,E., Pineda,R., Dieguez,C., Aguilar,E., Pinilla,L., Tena-Sempere,M. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006; 55(-9-):2602-2610. >>> Insulin; leptin; Saline; HCI; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle, or nondiabetic; replacement therapy (STZ-induced Diabetes); peptides; animal info (male, Wistar, adult).

P8167 Bidani,A.K., Picken,M., Hacioglu,R., Williamson,G., Griffin,K.A. Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance. American Journal of Physiology-Renal Physiology 2007; 292(-2-):F647-F654. >>> Insulin; SC; Rat; 16-20, 36-40 weeks; Replacement therapy (STZ-induced Diabetes); long-term study; pumps replaced every 4 weeks; peptides; animal info (male, Sprague-Dawley, 8 weeks old, 250 grams).

P8149 Kovacs,P., Morales,J.C., Karkanias,G.B. The effect of diabetes and centrally administered insulin on anterior hypothalamic estrogen receptor alpha immunoreactivity. ACTA DIABETOLOGICA 2007; 44(-1-):38-44. >>> Insulin, human; Saline; CSF/CNS (third ventricle); Rat; 2002; 14 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced Diabetes, ovariectomy); peptides; animal info (female, Sprague-Dawley, 175-200g.); tissue perfusion (ventricle).

P8128 Hartner,A., Cordasic,N., Klanke,B., Wittmann,M., Veelken,R., Hilgers,K.F. Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. American Journal of Physiology-Renal Physiology 2007; 292(-2-):F820-F827. >>> Losartan; IP; Rat; rat (transgenic); 2004; 4 weeks; Controls received mp w/ saline; replacement therapy (STZ-induced diabetes mellitus); animal info (male, Sprague-Dawley-Hanover, ren-2 Tg, 12 wks old, 250g.).

P8046 Taguchi,K., Kobayashi,T., Hayashi,Y., Matsumoto,T., Kamata,K. Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta. European Journal of Pharmacology 2007; 556(-1-3-):121-128. >>> Angiotensin II; Saline; Rat; 2ML2; 1 week; Plasma levels and blood pressure measured; cardiovascular; peptides; animal info (diabetic, male, Wistar, 8 weeks old, 200-230 grams); diabetes.

P8042 Wente,W., Efanov,A.M., Brenner,M., Kharitonenkov,A., Koester,A., Sandusky,G.E., Sewing,S., Treinies,I., Zitzer,H., Gromada,J. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 2006; 55(-9-):2470-2478. >>> Fibroblast growth factor-21; Saline; SC; Mice; 1002; 8 weeks; FGF-21 plasma levels taken; long-term study; pumps replaced every two weeks; animal info (C57BL/6, 8 weeks old); diabetes.

P8034 Xu,J., Lee,W.N.P., Phan,J., Saad,M.F., Reue,K., Kurland,I.J. Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes 2006; 55(-12-):3429-3438. >>> Lactate; glucose; Water; radio-isotopes; 13C tracer; SC; Mice; 2001D; 24 hours; Plasma levels taken; animal info (Balb/cByJ, 7-9 months old, 28 grams); anesthesia and implantation was<3 min/mouse; diabetes.

P8033 Xu,J., Gowen,L., Raphalides,C., Royer,K.K., Weinger,J.G., Renard,M., Troke,J.J., Vaitheesyaran,B., Lee,W.N.P., Saad,M.F., Sleeman,M.W., Teitell,M.A., Kurland,I.J. Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse. Diabetes 2006; 55(-12-):3372-3380. >>> Glucose; glycerol; Radio-isotopes; 13C tracer; 13C6 tracer; SC; Mice; 2001D; 24 hours; Plasma levels; animal info (14-18 weeks, 24-27 grams, male and female); diabetes; glycerol labeled with 13C.

P7985 Warne,J.P., Horneman,H.F., Wick,E.C., Bhargava,A., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores. Endocrinology 2006; 147(-11-):5443-5451. >>> Insulin, methylene blue; Saline; IV (jugular); Rat; 2002; ; Functionality of mp verified by dye infusion; replacement therapy (diabetic); no stress (see pg. 5444); good methods; peptides; animal info (male, Sprague-Dawley, 275 grams); diabetes; PE-60 fused to PE-5.

P7969 Garcia-Vicente,S., Yraola,F., Marti,L., Gonzalez-Munoz,E., Garcia-Barrado,M.J., Canto,C., Abella,A., Bour,S., Artuch,R., Sierra,C., Brandi,N., Carpene,C., Moratinos,J., Camps,M., Palacin,M., Testar,X., Guma,A., Albericio,F., Royo,M., Mian,A., Zorzano,A. Oral insulin-mimetic compounds that act independently of insulin. Diabetes 2007; 56(-2-):486-493. >>> B6V10; decavanadate; SC; Rat; 12 days; Animal info (male, Wistar, 180-220 grams); diabetes.

P7834 Zimanyi,M.A., Denton,K.M., Forbes,J.M., Thallas-Bonke,V., Thomas,M.C., Poon,F., Black,M.J. A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products. Diabetologia 2006; 49(-4-):801-810. >>> BSA, AGE-modified; BSA; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; no stress (see pg. 804); animal info (male, Wistar-Kyoto, 20-24 wk. old); AGES (advanced gylcation end-products); comparable w/ advanced diabetes.

P7829 Toth,C., Brussee,V., Zochodne,D.W. Remote neurotrophic support of epidermal nerve fibres in experimental diabetes. Diabetologia 2006; 49(-5-):1081-1088. >>> Insulin; insulin-like growth factor-1; Saline; SC; CSF/CNS (intrathecal, lumbar); Rat; 2002; 1 month; Controls received mp w/ vehicle; replacement therapy (stz-induced diabetes); pumps replaced after 2 weeks; peptides; animal info (male, Sprague-Dawley, 300-350g.); comparison of SC mp vs. IT mp.

P7773 Yang,Z.D., Chen,M., Carter,J.D., Nunemaker,C.S., Garmey,J.C., Kimble,S.D., Nadler,J.L. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochemical and Biophysical Research Communications 2006; 344(-3-):1017-1022. >>> Lisofylline; exendin-4; Saline; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; replacement therapy (non-obese diabetes); animal info (C57BL/6J, NOD/LtJ, 18-30 wk. old).

P7756 Shibuya,K., Kanasaki,K., Isono,M., Sato,H., Omata,M., Sugimoto,T., Araki,S.I., Isshiki,K., Kashiwagi,A., Haneda,M., Koya,D. N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice. Diabetes 2005; 54(-3-):838-845. >>> Peptide, Ac-SDKP; Balanced salt solution; SC; Mice; 2004; 8 weeks; Controls received mp w/ vehicle, or controld peptide; functionality of mp verified by plasma AC-SDKP levels; replacement therapy (diabetes); long-term study; pumps replaced at 4 weeks; no stress (see pg. 839, 843); peptides; animal info (male, db/db, db/m, 10 wk. old).

P7754 Awad,A.S., Huang,L.P., Ye,H., Duong,E.T.A., Bolton,W.K., Linden,J., Okusa,M.D. Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy. American Journal of Physiology-Renal Physiology 2006; 290(-4-):F828-F837. >>> ATL146e; ATL313; PBS; DMSO; SC; Rat; mice; 2004; 4,5,6 weeks; Controls received mp w/ vehicle; no stress (see pg. F830); half-life (p. F831) ATL313 has a longer half-life than ATL1466; animal info (Sprague-Dawley, 14 wk old, 245-255g.; C57BL/6, 7-8 wk. old, A2A-KO/C57BL/6, 20g.); STZ induced diabetes.

P7720 Zelena,D., Mergl,Z., Makara,G.B. The role of vasopressin in diabetes mellitus-induced hypothalamo-pituitary-adrenal axis activation: Studies in Brattleboro rats. Brain Research Bulletin 2006; 69(-1-):48-56. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; 18 days; Controls received sham surgery; pumps replaced after 10 days; animal info (male, brattleboro, di/di, di/+); v2 agonist; diabetes; A.K.A dDavp or Desmopressin or desmopresinum.

P7673 Dragonas,C., Mueller,A., Maltaris,T., Kraemer,P., Dimmler,A., Jaeger,W., Beckmann,M.W., Dittrich,R. Role of insulin in the progression of ovarian sex cord stromal tumors in rats. Journal of Cancer Research and Clinical Oncology 2005; 131(-11-):751-757. >>> Insulin; SC; Rat; 28, 56, 84 days; Controls received mp w/ saline; replacement therapy (ovariectomy, STZ-induced diabetes); long-term study; pumps replaced every 28 days; no stress (see pg.753); cancer (sex cord stomal); animal info (female, Lewis, 60 days old, 150-210 g).

P7672 Gorin,Y., Block,K., Hernandez,J., Bhandari,B., Wagner,B., Barnes,J.L., Abboud,H.E. Nox4 NAD(P) H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. Journal of Biological Chemistry 2005; 280(-47-):39616-39626. >>> Oligonucleotide, phosphorothioate antisense; oligonucleotide, phosphorothioate sense; SC; Rat; 2 weeks; Controls received mp w/ sense oligo or not treatment; functionality of mp verified by Nox4 levels in kidney cortex; replacement therapy (STZ-induced diabetes); anti-sense (Nox4); animal info (male, Sprague-Dawley, 200-225 g).

P7660 Knauf,C., Cani,P.D., Perrin,C., Iglesias,M.A., Maury,J.F., Bernard,E., Benhamed,F., Gremeaux,T., Drucker,D.J., Kahn,C.R., Girard,J., Tanti,J.F., Delzenne,N.M., Postic,C., Burcelin,R. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. Journal of Clinical Investigation 2005; 115(-12-):3554-3563. >>> Exendin (9-39); IP; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (diet-induced diabetes); Alzet brain infusion kit used; animal info (C57BL/6J, male, 12 week old); BIK used with other apparatus for short term icv infusion.

P7564 Ichinose,K., Maeshima,Y., Yamamoto,Y., Kitayama,H., Takazawa,Y., Hirokoshi,K., Sugiyama,H., Yamasaki,Y., Eguchi,K., Makino,H. Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model. Diabetes 2005; 54(-10-):2891-2903. >>> Endostatin, human (1-27); PBS; SC; Mice; 2004; 2 weeks; Controls received mp w/ vehicle; replacement therapy (STZ diabetes); dose-response (fig. 2); no stress (see pg.2892); peptides; animal info (female, C57BL/6, 21-26 g).

P7526 Toyoshima,Y., Gavrilova,O., Yakar,S., Jou,W., Pack,S., Asghar,Z., Wheeler,M.B., LeRoith,D. Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology 2005; 146(-9-):4024-4035. >>> Leptin; SC; Mice; 2002; 14 days; Controls received mp w/ saline; functionality of mp verified by serum leptin levels; replacement therapy (type 2 diabetes); peptides; animal info (MKR male, 6-7 wk. old, wild type 20-25 g).

P7512 Visentin,V., Bour,S., Boucher,M., Prevot,D., Valet,P., Ordener,C., Parini,A., Carpene,C. Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide. European Journal of Pharmacology 2005; 522(-1-3-):139-146. >>> Tyramine; tyramine, 14C-; SC; Rat; 3 weeks; Controls received no treatment, normoglycemic; replacement therapy (STZ-induced diabetes); pumps replaced at 2 weeks; animal info (male, wistar, 7 wk old); amine oxidase substrate.

P7358 El Midaoui,A., Ongali,B., Petcu,M., Rodi,D., De Champlain,J., Neugebauer,W., Couture,R. Increases of spinal kinin receptor binding sites in two rat models of insulin resistance. Peptides 2005; 26(-8-):1323-1330. >>> Insulin; SC; Rat; 2002; 2 weeks; Peptides; diabetes.

P7093 Akirav,E.M., Chan,O., Inouye,K., Riddell,M.C., Matthews,S.G., Vranic,M. Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats. METABOLISM-CLINICAL AND EXPERIMENTAL 2004; 53(-12-):1558-1564. >>> Leptin, recomb. mouse; PBS; SC; Rat; 4 days; Controls received mp w/ vehicle; replacement therapy (STZ-diabetes); peptides; STZ induced diabetes.

P7088 Aubel,B., Kayser,V., Mauborgne,A., Farre,A., Hamon,M., Bourgoin,S. Antihyperalgesic effects of cizolirtine in diabetic rats: Behavioral and biochemical studies. Pain 2004; 110(-1-2-):22-32. >>> Cizolirtine; paroxetine hydrochloride; Saline; DMSO; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; replacement therapy (STZ-induced diabetes); dose-response (fig. 4); 20% DMSO.

P6969 Samnegard,B., Jacobson,S.H., Jaremko,G., Johansson,B.L., Ekberg,K., Isaksson,B., Eriksson,L., Wahren,J., Sjoequist,M. C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. NEPHROLOGY DIALYSIS TRANSPLANTATION 2005; 20(-3-):532-538. >>> C-peptide; Saline; SC; Rat; 2002; 4 weeks; Peptides; diabetes.

P6956 El Midaoui,A., De Champlain,J. Effects of glucose and insulin on the development of oxidative stress and hypertension in animal models of type 1 and type 2 diabetes. Journal of Hypertension 2005; 23(-3-):581-588. >>> Insulin; Saline; glutamic acid; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; insulin plasma levels taken; cardiovascular; peptides; diabetes; 0.7% glutamic acid added to prevent insulin aggregation.

P6949 Fowler,M., Virostko,J., Chen,Z.Y., Poffenberger,G., Radhika,A., Brissova,M., Shiota,M., Nicholson,W.E., Shi,Y.B., Hirshberg,B., Harlan,D.M., Jansen,E.D., Powers,A.C. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation 2005; 79(-7-):768-776. >>> Insulin, human; SC; Mice (SCID); 1002; 7,10 days; Diabetes; bioluminescence imaging (BLI); IVIS 200 system used after pumps were removed.

P6915 Poulaki,V., Joussen,A.M., Mitsiades,N., Mitsiades,C.S., Iliaki,E.F., Adamis,A.P. Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy. American Journal of Pathology 2004; 165(-2-):457-469. >>> Wortmannin; ly294002; antibody, monoclonal aLR-3; SP600125; SN50; geldanamycin; IP; Rat; 2002; 7 days; Enzyme inhibitor (P1-3K, JNK); diabetes.

P6912 Lee,F.T.H., Cao,Z.M., Long,D.M., Panagiotopoulos,S., Jerums,G., Cooper,M.E., Forbes,J.M. Interactions between angiotensin II and NF-kappa B dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. Journal of the American Society of Nephrology 2004; 15(-8-):2139-2151. >>> PDTC; PD123319; SC; Rat; 2ML4; 4 weeks; Diabetes; PDTC is (Pyrrolidine dithiocarbamate).

P6810 Delporte,M.L., El Mkadem,S.A., Quisquater,M., Brichard,S.M. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004; 287(-3-):E446-E453. >>> Leptin, recomb. mouse; Sodium citrate; SC; Mice; 2001; 3, 6 days; Controls received mp w/ vehicle; replacement therapy (obese (ob/ob) mice); peptides; obesity; diabetes.

P6798 Brussee,V., Cunningham,F.A., Zochodne,D.W. Direct insulin signaling of neurons reverses diabetic neuropathy. Diabetes 2004; 53(-7-):1824-1830. >>> Insulin, human; FITC-Insulin; Insulin-like growth factor I; antibody, polyclonal anti-rat insulin; dye, india ink; antibody, polyclonal anti-albumin; Saline; SC; CSF/CNS (intrathecal); Rat; 2, 4 weeks; Controls received mp w/ vehicle or anti-albumin Ab; functionality of mp verified by dye; replacement therapy (streptozotocin induced diabetes); india ink used to confirm catheter placement and intrathecal delivery.

P6794 Pittner,R.A., Moore,C.X., Bhavsar,S.P., Gedulin,B.R., Smith,P.A., Jodka,C.M., Parkes,D.G., Paterniti,J.R., Srivastava,V.P., Young,A.A. Effects of PYY[3-36] in rodent models of diabetes and obesity. International Journal of Obesity 2004; 28(-8-):963-971. >>> Peptide YY (3-36); PBS; SC; Rat; mice; 2004; 2ML4; 4, 8 weeks; Controls received mp w/ vehicle; dose-response (fig. 1); comparison of IP injections vs. mp; long-term study; pumps replaced after 4 weeks; diabetes; obesity; peptide.

P6762 Suganami,T., Mukoyama,M., Mori,K., Yokoi,H., Koshikawa,M., Sawai,K., Hidaka,S., Ebihara,K., Tanaka,T., Sugawara,A., Kawachi,H., Vinson,C., Ogawa,Y., Nakao,K. Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy. FASEB Journal 2004; 18(-13-):U261-U283. >>> Leptin, recomb. mouse; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by serum leptin concentrations; peptides; diabetes.

P6742 Ichihara,A., Hayashi,M., Kaneshiro,Y., Suzuki,F., Nakagawa,T., Tada,Y., Koura,Y., Nishiyama,A., Okada,H., Uddin,M.N., Nabi,A.H.M.N., Ishida,Y., Inagami,T., Saruta,T. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle'' region for nonproteolytic activation of prorenin. Journal of Clinical Investigation 2004; 114(-8-):1128-1135. >>> Peptide, prorenin handle region; SC; Rat; 2004; 8, 16, 24 weeks; Controls received mp w/ saline; long-term study; pumps replaced every 28 days; no stress (see pg.1129); enzyme inhibitor (prorenin); peptides; "Continuous infusion of HRP by subcutaneous minipumps did not affect the body weight, BP, or blood glucose levels of either control or diabetic rats during the 24-week treatment period." (p.1129); diabetes.

P6695 Qi,Z.H., Whitt,I., Mehta,A., Jin,J.P., Zhao,M., Harris,R.C., Fogo,A.B., Breyer,M.D. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. American Journal of Physiology-Renal Physiology 2004; 286(-3-):F590-F596. >>> FITC-inulin; Saline; IP; Mice; 1007D; 7 days; Functionality of mp verified by FITC-inulin plasma levels takenl; comparison of bolus injections vs. IP mp; good methods p. F591; multiple pumps per animal (2); diabetes; in detail solubilization methods; "using two pumps, a plasma fluorescence level two to six times higher than background was achieved." p.F591.

P6669 Tamarat,R., Silvestre,J.S., Ricousse-Roussanne,S., Barateau,V., Lecomte-Raclet,L., Clergue,M., Duriez,M., Tobelem,G., Levy,B.I. Impairment in ischemia-induced neovascularization in diabetes - Bone marrow mononuclear cell dysfunction and therapeutic potential of placenta growth factor treatment. American Journal of Pathology 2004; 164(-2-):457-466. >>> Placental growth factor; SC; Mice; 2001; 14 days; Diabetes, placenta growth factor (PIGF) is a VEGF homologue; ischemia.

P6461 Zhang,X.L., Lassila,M., Cooper,M.E., Cao,Z.M. Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors. Hypertension 2004; 43(-2-):276-281. >>> Angiotensin II; PD123319; Sodium chloride; acetic acid; SC; Rat; 2002; 2004; 2,4 weeks; Controls received mp w/ vehicle; STZ induced diabetes; multiple pumps per animal (2).

P6453 Cui,Y.X., Huang,L., Elefteriou,F., Yang,G.Q., Shelton,J.M., Giles,J.E., Oz,O.K., Pourbahrami,T., Lu,C.Y.H., Richardson,J.A., Karsenty,G., Li,C. Essential role of STAT3 in body weight and glucose homeostasis. MOLECULAR AND CELLULAR BIOLOGY 2004; 24(-1-):258-269. >>> Leptin, recomb. human; Saline; CSF/CNS (third ventricle); Mice (knockout, transgenic); 2004; 28 days; ALZET brain infusion kit 2; peptides; obesity; diabetes.

P6449 Kusaka,I., Kusaka,G., Zhou,C., Ishikawa,M., Nanda,A., Granger,D.N., Zhang,J.H., Tang,J.P. Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. American Journal of Physiology-Heart and Circulatory Physiology 2004; 286(-6-):H2442-H2451. >>> Candesartan; SC; Rat; 14 days; Ischemia (cerebral); diabetes; no side effects of minipump placement were noticed; pump model not listed.

P6421 Ruzicska,E., Foldes,G., Lako-Futo,Z., Sarman,B., Wellmann,J., Szenasi,G., Tulassay,Z., Ruskoaho,H., Toth,M., Somogyi,A. Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overload. Journal of Hypertension 2004; 22(-6-):1191-1200. >>> Angiotensin II; SC; Rat; 24 hours; Blood pressure taken; cardiovascular; peptides; diabetes; 1 ul/hr pump used (model not listed).

P6395 Dunn,S.R., Qi,Z.H., Bottinger,E.P., Breyer,M.D., Sharma,K. Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney International 2004; 65(-5-):1959-1967. >>> FITC-inulin; Sodium chloride; IP; Mice; 1007D; ; FITC-inulin plasma levels taken; multiple pumps per animal (2); solution was filtered during pump filling; diabetes.

P6383 Kim,D.G., Sands,J.M., Klein,J.D. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F760-F766. >>> Vasopressin; Saline; SC; Rat; 2002; 5,12 days; Functionality of mp verified by urine osmolality; diabetes.

P6101 Lupien,S.B., Bluhm,E.J., Ishii,D.N. Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. Journal of Neuroscience Research 2003; 74(-4-):512-523. >>> Insulin-like growth factor; antiserum, human IGF II; serum, preimmune; Acetic acid; CSF, artificial; SC; CSF/CNS; Rat; 7.5 weeks; Pumps replaced every 19 days; ALZET brain infusion kit used; peptides; diabetes; IGF delivered SC and separate study for ICV infusion of anti-IGF-II antiserum or preimmune serum; (PIS) dissolved in aCSF; cannulae placement verified post experiment by bromophenol blue.

P6082 Hayashi,T., Sohmiya,K., Ukimura,A., Endoh,S., Mori,T., Shimomura,H., Okabe,M., Terasaki,F., Kitaura,Y. Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart. HEART 2003; 89(-10-):1236-1242. >>> Candesartan; IP; Rat; 2002; 6 weeks; Long-term study; pumps replaced every two weeks; diabetes.

P6031 Kobayashi,T., Kaneda,A., Kamata,K. Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta. British Journal of Pharmacology 2003; 140(-2-):285-294. >>> Insulin; Saline; SC; Rat; 2ML2; 2 weeks; Insulin plasma levels taken; cardiovascular; peptides; diabetes.

P5688 Abella,A., Marti,L., Camps,M., Claret,M., Fernandez-Alvarez,J., Gomis,R., Guma,A., Viguerie,N., Carpene,C., Palacin,M., Testar,X., Zorzano,A. Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. Diabetes 2003; 52(-4-):1004-1013. >>> Benzylamine hydrochloride; SC; Rat; 2 weeks; 2-week stability verified by in vitro glucose transport assay; diabetes..

P5498 Granda,T.G., Velasco,A. Sodium and potassium clearance rhythmicity in diabetic rats with insulin treatment. LIFE SCIENCES 2002; 71(-21-):2475-2487. >>> Insulin; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; replacement therapy (streptozotocin-induced diabetes); peptides.

P5058 Gill,R., Nazir,T.M., Wali,R., Sitrin,M., Brasitus,T.A., Ramaswamy,K., Dudeja,P.K. Regulation of rat ileal NHE3 by 1,25(OH)(2)-vitamin D-3. Digestive Diseases and Sciences 2002; 47(-5-):1169-1174. >>> Vitamin D3, 1, 25-dihydroxy-; SC; rat; 2001; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum Vitamin D3 levels; streptozotocin induced diabetes, p. 1170.

P5011 Imai,S., Tezuka,H., Fujita,K. A factor of inducing IgE from a filarial parasite prevents insulin-dependent diabetes mellitus in nonobese diabetic mice. Biochemical and Biophysical Research Communications 2001; 286(--):1051-1058. >>> Antigen, recombinant Dirofilaria immitis-derived; PBS; SC; mice; ; controls received mp w/ vehicle; dose-response (fig. 3); IgE plasma levels; immunology; autoimmune diabetes; DiAg is a factor from Dirofilaria immitis that induces antigen non-specific IgE, suppresses anaphylaxis; IgE immune response to DiAg (p. 1054)..

P4906 Holness,M.J., Sugden,M.C. Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver. Endocrinology 2001; 142(-9-):3742-3748. >>> Dexamethasone; SC; rat (pregnant); 5 days; controls received sham surgery; administration of dexamethasone was from day 14 to day 19 of gestation; "priming" SC injection of dexamethasone given before pump implantation; insulin resistance, diabetes;.

P4829 Yuan,M, Konstantopoulos,N, Lee,J, Hansen,L, Li,Z.-W, Karin,M, Shoelson,S.E  Science 2001; 293(--):1673-1677. >>> Acetylsalicylic acid; salicylate, sodium; SC; Rat; mice; 2002; 2ML2; 3-4 weeks; Controls received mp w/ vehicle; 2ML2 used in rats, 2002 used in mice; acetylsalicylic acid also called aspirin: dose was 120 mg/kg/day; diabetes (type II).

P4772 Fedele,M.J., Lang,C.H., Farrell,P.A. Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise. Am.J.Physiol.Endocrinol Metab. 2001; 280(--):E877-E885. >>> Antibody, anti-IGF-I polyclonal;; Saline;; SC;; rat;; 2ML1;; 7 days;; Controls received mp w/ non-specific Immunoglobulin G; functionality of mp verified by plasma levels; immunology; peptides; rats underwent partial pancreatetomy to create diabetic state; antibody delivered wan as anti-insulin-like growth factor I antibody; diabetes; pumps used for passive immunization against IGF-I; anti IGF-I antibody used is called SC-7144;.

P3672 Dombrowski,F., Pfeifer,U. Hyperproliferative state of liver acini and pancreatic islets after intraportal transplantation of a small mass of islets of langerhans in streptozotocininduced diabetic rats. Exp.Clin.Endocrinol. 1995; 103(--):112-117. >>> Uridine, bromodeoxy-;; Saline;; SC;; rat;; 2ML1;; 6 days;; rats had streptozotocin-induced diabetes;.

P3628 Moglia,B.B., Phelps,D.S. Changes in surfactant protein A mRNA levels in a rat model of insulin-treated diabetic pregnancy. Pediatr.Res. 1996; 39(-2-):241-247. >>> Insulin; SC; rat (pregnant); 2001; 2002; 20 days; controls received mp w/ saline; functionality of mp verified by blood glucose levels during treatment; replacement therapy (streptozotocin-induced diabetes); comparison of daily sub-q injections vs. mp; pumps replaced after 10 days; teratology; peptides; Iletin insulin used.

P3403 Fisher,W.E., Boros,L.G., Schirmer,W.J. Reversal of enhanced pancreatic cancer growth in diabetes by insulin. Surgery 1995; 118(--):453-458. >>> Insulin; Glycerin; Phenol; Water, distilled; SC; hamster; 2002; 21 days; controls received mp w/diluent; functionality of mp verified by plasma glucose levels; replacement therapy (streptozotocin-induced diabetes); pumps replaced after 14 days; cancer; peptides.

P3250 Lau,C., Sullivan,M.K., Hazelwood,R.L. Effects of diabetes mellitus on lactation in the rat. Proc.Soc.Exp.Biol.Med. 1993; 204(--):81-89. >>> Insulin; BSA; Glutamic acid, L-; Saline; SC; rat; 2002; 14 days; controls received sham operation w/wax pellet; replacement therapy (streptozotocin-induced diabetes); peptides.

P3220 Jara,A., Bover,J., Felsenfeld,A.J. Development of secondary hyperparathyroidism and bone disease in diabetic rats with renal failure. Kidney Int. 1995; 47(--):1746-1751. >>> Insulin; Glycerine; NaOH; HCI; Glutamic acid; SC; rat; 2002; 14 days; functionality of mp verified by blood glucose levels; replacement therapy (streptozotocin-induced diabetes); comparison of injections vs. mp; peptides.

P3189 Gouvea,W., Roth,D., Alpert,H., Kelley,J., Pardo,V., Vaamonde,C.A. Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat. P.S.E.B.M. 1994; 206(--):445-453. >>> Insulin; Aspartic acid; Glutamic acid; SC; rat; 2002; 15 days; controls received mp with ringers; replacement therapy (streptozotocin-induced diabetes); toxicology; peptides.

P3015 Vanderweele,D.A  Physiol.Behav. 1993; 54(--):477-485. >>> Insulin; Citrate buffer; IP; rat; 6 days; controls received no pump or vehicle in mp; functionality of mp verified by residual volume; replacement therapy (streptozotocin-induced diabetes); comparison of bolus injections vs. mp; no stress (see pg. 478); peptides; pumps secured to peritoneal wall; infusion proved more effective than injection.

P3007 Friedman,M.I., Ramirez,I. Food intake in diabetic rats: relationship to metabolic effects of insulin treatment. Physiol.Behav. 1994; 56(-2-):373-378. >>> Insulin; Saline; Glycerol; Glutamic acid; Aspartic acid; Phenol; SC; rat; 2001; 1 week; controls received mp w/ vehicle and were or were not diabetic; replacement therapy (streptozotocin-induced diabetes).

P2939 Strack,A.M., Sebastian,R.J., Schwartz,M.W., Dallman,M.F. Glucocorticoids and insulin: reciprocal signals for energy balance. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.37) 1995; 268(--):R142-R149. >>> Insulin, synthetic human; SC; rat; 2001; 5 days; controls received mp with saline; replacement therapy (streptozotocin-induced diabetes); peptides.

P2909 O'Mara,B.A., Dittrich,W., Lauterio,T.J., St.Germain,D.L. Pretranslational regulation of type I 5'-deiodinase by thyroid hormones and in fasted and diabetic rats. Endocrinology 1993; 133(--):1715-1723. >>> Insulin, pork NPH; SC; rat; 2ML4; 2 weeks; controls received mp with saline; replacement therapy (streptozotocin-induced diabetes); peptides.

P2892 Ohishi,K., Okwueze,M.I., Vari,R.C., Carmines,P.K. Juxtamedullary microvascular dysfunction during the hyperfiltration stage of diabetes mellitus. Am.J.Physiol. 1994; 267(--):F99-F105. >>> Insulin; IP; rat; 2002; 2 weeks; controls received mp with diluent; functionality of mp verified by blood glucose levels; replacement therapy (streptozotocin-induced diabetes); peptides; rats were given penicillin G procaine prophylactically; "osmotic minipumps provided a constant source of insulin to avoid the wide variations in blood glucose levels that occur when insulin is administered by daily injection".

P2870 Ohishi,O., Carmines,P.K. Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus. J.Am.Soc.Nephrol. 1995; 5(--):1559-1566. >>> Insulin; IP; rat; 2002; 2 weeks; controls received mp with vehicle and no streptozotocin shot; replacement therapy (streptozotocin-induced diabetes); 60,000 U of penicillin G procaine given after surgery.

P2746 Enea,N.A., Hollis,T.M., Kern,J.A., Gardner,T.W. Histamine H1 receptors mediate increased blood-retinal barrier permeability in experimental diabetes. Arch.Ophthalmol. 1989; 107(--):270-274. >>> Insulin, porcine; Glycerin; Phenol; Water, double-distilled; Glutamic acid; SC; rat; 7 days; controls received no treatment or were non-diabetic; replacement therapy (streptozocin-induced diabetes); peptides.

P2234 Cotter,M.A., Dines,K.C., Cameron,N.E. Prevention and reversal of motor and sensory peripheral nerve conduction abnormalities in streptozotocin-diabetic rats by the prostacyclin analogue iloprost. Naunyn-Schmiedeberg's Arch.Pharmacol. 1993; 347(--):534-540. >>> Iloprost; Water; IV (jugular); rat; 2ML4; 2 months; controls received mp w/vehicle; long-term study, pumps replaced every month; diabetes induced by streptozotocin.

P2232 Belahsen,R., Deshaies,Y. Involvement of insulinemia in the postprandial hypotriacylglycerolemia induced by prazosin in the rat. Metabolism 1993; 42(-10-):1301-1309. >>> Insulin, pork zinc; Glutamic acid; SC; rat; 2002; no duration posted; controls received mp w/carrier; functionality of mp verified by plasma levels and RIA; replacement therapy (streptozotocin-induced diabetes).

P2189 Deshaies,Y., Geloen,A., Paulin,A., Bukowiecki,L.J. Restoration of lipoprotein lipase activity in insulin-deficient rats by insulin infusion is tissue-specific. Can.J.Physiol.Pharmacol. 1991; 69(--):746-751. >>> Insulin, pork zinc; Albumin, bovine serum; Glutamic acid; Water; SC; rat; 2002; 1,4 days; controls received mp w/vehicle; replacement therapy (streptozotocin-induced diabetes); peptides.

P2186 Bornfeldt,K.E., Arnqvist,H.J., Capron,L. In vivo proliferation of rat vascular smooth muscle in relation to diabetes mellitus insulin-like growth factor I and insulin. Diabetologia 1992; 35(--):104-108. >>> Insulin; Insulin-like growth factor I; Saline; SC; rat; 5 days; controls received mp w/ saline; functionality of mp verified by serum levels; replacement therapy (streptozotocin-induced diabetes); peptides.

P2184 Bornfeldt,K.E., Skottner,A., Arnqvist,H.J. In-vivo regulation of messenger RNA encoding insulin-like growth factor-I (IGF-I) and its receptor by diabetes, insulin and IGF-I in rat muscle. J.Endocrinol. 1992; 135(--):203-211. >>> Insulin; Insulin-like growth factor I; Saline; SC; rat; 2ML1; 2ML2; 4 days; controls received mp w/saline; functionality of mp verified by serum levels, p. 205; replacement therapy (streptozotocin-induced diabetes); comparison of sc injections vs. mp; peptides.

P2087 Tal,M., Kahn,B.B., Lodish,H.F. Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats. Endocrinology 1991; 129(-4-):1933-1941. >>> Insulin; Saline; SC; rat; 2001; 7 days; functionality of mp verified by plasma insulin levels; replacement therapy (streptozotocin-induced diabetes); peptides.

P1795 Erkstrom,A.R., Kanje,M., Skottner,A. Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency. Brain Research 1989; 496(--):141-147. >>> Insulin, bovine; Tris-HCl buffer; SC; rat; 2001; 7 days; replacement therapy (streptozotocin-induced diabetes).

P1676 Geloen,A., Trayhurn,P. Regulation of the level of uncoupling protein in brown adipose tissue by insulin. Am.J.Physiol. 1990; 258(-2-):R418-R424. >>> Insulin, pork; SC; rat; 2002; 12 days; replacement therapy (streptozotocin-induced diabetes); peptides.

P1605 Goodman,A.D., Hoekstra,S., Monahan,J.W., Danis,E.H. Suppressive effect of glucose administration on the binding of prolactin by rat liver. Metabolism 1990; 39(-6-):568-576. >>> Insulin, porcine; Saline; SC; rat; no duration posted; replacement therapy (streptozotocin-induced diabetes).

P1461 Gouvea,W.L., Alpert,H.C., Kelley,J., Pardo,V., Vaamonde,C.A. Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. Kidney Int. 1989; 35(--):1041-1048. >>> Insulin; SC; rat; 2002; 15 days; functionality of mp verified by urine glucose; replacement therapy (streptozotocin induced diabetes); peptides.

P1458 Eriksson,R.S., Thunberg,L., Eriksson,U.J. Effects of interrupted insulin treatment on fetal outcome of pregnant diabetic rats. Diabetes 1989; 38(--):764-772. >>> Insulin, human; SC; rat; 2002; 5, 7, 9, 11 days; replacement therapy (streptozotocin induced diabetes); pump replaced 2-4 days later; toxicology/teratology; peptides.

P1355 Geloen,A., Collet,A.J., Guay,G., Bukowiecki,L.J. Insulin stimulates in vivo cell proliferation in white adipose tissue. Am.Physiol.Soc. 1989; 256(--):C190-C196. >>> Insulin; Albumin; Glutamic acid; Water; SC; rat; 2002; 1, 4, 8 days; replacement therapy (streptozocin-induced diabetes); peptides.

P1329 Rebuffat,P., Belloni,A.S., Malendowicz,L.K., Mazzochi,G., Gottardo,G., Nussdorfer,G.G. Zona glomerulosa morphology and function in streptozotocin-induced diabetic rats. Endocrinology 1988; 123(-2-):949-955. >>> ACTH; Angiotensin II; Captopril; Dexamethasone; Insulin; Saline; SC; rat; 2002; 2 weeks; dose-response (text); functionality of mp verified by plasma levels; replacement t; antihypertensive therapy (streptozotocin-induced diabetes); peptides; antihypertensive.

P1311 Peterson,J., Ross,J., Rabkin,R. Effect of insulin therapy on established diabetic nephropathy in rats. Diabetes 1988; 37(--):1346-1350. >>> Insulin; Saline; SC; rat; 5 months; dose response (text); comparison of SC injections vs. mp infusion; replacement therapy (streptozotocin-induced diabetes); long-term study; pump replaced every 10 days; peptides.

P1234 McCall,A.L., Sussman,I., Tornheim,K., Cordero,R., Ruderman,N.B. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. Am.Physiol.Soc. 1988; 254(--):E272-E278. >>> Insulin, porcine; SC; rat; 4 days; pump model not stated; controls received mp w/ unspecified vehicle; insulinoma-implanted rats; mp used in 2 exp.; replacement therapy (streptozotocin induced diabetes); peptides.

P1214 Roy,A.K., Chatterjee,B., Prasad,M.S.K., Unakar,N.J. Role of insulin in the regulation of the hepatic messenger RNA for alpha2u-globulin in diabetic rats. J.Biol.Chem. 1980; 255(-23-):11614-11618. >>> Insulin, porcine; Saline; SC; rat; 1701; 4 days; controls received mp w/ saline; replacement therapy (streptozotocin induced diabetes); peptides.

P1177 Smith,D.R., Rodway,M.R., Haniak,W.A., Bellward,G.D. Hepatic estrogen and androgen receptors and binding proteins in streptozotocin-diabetic male wistar rats. Diabetologia 1987; 30(--):957-962. >>> Growth hormone, ovine; Saline; SC; rat; 2001; no duration posted; streptozotocin induced diabetes; comparison of sc injections vs. mp infusion; peptides.

P1157 Friedman,M.I., Ramirez,I. Insulin counteracts the satiating effect of a fat meal in rats. Physiol.Behav. 1987; 40(-5-):655-659. >>> Insulin; Aspartic acid; Glutamic acid; Glycerol; Phenol; Saline; SC; rat; 2001; 8 days; rats were fed corn oil to ascertain the effects of insulin on diet; comparison of sc injections vs. mp infusion; replacement therapy (streptozotocin induced diabetes; peptides.

P1153 Griffen,S.C., Russell,S.M., Katz,L.S., Nicoll,C.S. Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver. Proc.Natl.Acad.Sci. 1987; 84(--):7300-7304. >>> Insulin; Glutamic acid, l-; Glycerol; Heparin; Sodium azide; IV (hepatic portal); IV (jugular); rat; 14 days; Pump model not stated; controls received mp w/ vehicle; mp connected to catheter; 2 doses of agent infused; replacement therapy (streptozotocin induced diabetes); peptides; tissue perfusion; 10% sodium heparin, v/v; 1000 U/ml of heparin; animal info (Long-Evans, m, 130 g).

P1127 Gavin,L.A., Cavalieri,R.R., Moeller,M., McMahon,F.A., Castle,J.N., Gulli,R. Brain lipoprotein lipase is responsive to nutritional and hormonal modulation. Metabolism 1987; 36(-10-):919-924. >>> Insulin; Triiodothyronine; SC; rat; 2001; 4, 7 days; dose-response; replacement therapy (streptozotocin induced diabetes, thyroidectomy); peptides.

P1118 Bestetti,G.E., Junker,U., Locatelli,V., Rossi,G.L. Continuous subtherapeutic insulin counteracts hypothalamopituitary-gonadal alterations in diabetic rats. Diabetes 1987; 36(--):1315-1319. >>> Insulin, porcine; Glycerol; SC; rat; 2001; 4 weeks; replacement therapy (streptozotocin induced diabetes); pump replaced each week; peptides.

P1059 Roesler,W.J., Khandelwal,R.L. Regulation of rat liver glycogen phosphorylase concentration by in vivo relative levels of glucagon and insulin. Endocrinology 1987; 121(-1-):227-232. >>> Glucagon; Insulin, porcine; Glutamate; Glycerol; Phenol; SC; rat; 2001; 2ML1; 7 days; controls received 2001 mp w/insulin diluent; insulin infused w/glycerol, phenol, glutamate; glucagon infused w/phenol and glycerol; replacement therapy (streptozotocin induced diabetes); peptides.

P0932 Craven,P.A., Caines,M.A., DeRubertis,F.R. Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats: Relationship to the hyperfiltration of early diabetes. Metabolism 1987; 36(-1-):95-103. >>> Insulin; Saline; IP; rat; 2002; no duration posted; controls received mp w/vehicle; peptides; replacement therapy (streptozotocin induced diabetes).

P0926 Naray-Fejes-Toth,A., Feges-Toth,Geza. Dexamethasone does not inhibit antidiuretic hormone-stimulated prostaglandin production in vivo. Endocrinology 1986; 119(-6-):2856-2860. >>> Dexamethasone; Saline; SC; rat; 2001; 7 days; controls received mp w/vehicle; diabetes; Vasopressin, 1-desamino-8-D arginine admin. on 5th day of mp infusion.

P0914 Nomikos,I.N., Prowse,S.J., Carotenuto,P., Lafferty,K.J. Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice. Diabetes 1986; 35(--):1302-1304. >>> Desferrioxamine; SC; mice; 2002; no duration posted; transplantation of islet tissue; genetic diabetes; immunology; also called Deferoxamine.

P0829 Kruszynska,Y.T., Home,P.D., Alberti,K.G.M.M. In vivo regulation of liver and skeletal muscle glycogen synthase activity by glucose and insulin. Diabetes 1986; 35(--):662-667. >>> Insulin; SC; rat; 2002; 5 days; replacement therapy (streptozotocin induced diabetes); peptides.

P0806 Kline,R.L., Patel,K.P., Mercer,P.F. Enhanced noradrenergic activity in kidney of brattleboro rats with diabetes insipidus. Am.J.Physiol. 1986; 250(--):R567-R572. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 7 days; vasopressin tannate given by sc injection in one group, mp infusion of Vasopressin, 1-desamino-8-D arginine in other group; diabetes; peptides.

P0750 Tanaka,N., Leaning,M., Taylor,M., Summerfield,J.A. The effects of diabetes and insulin on glycoprotein metabolism by rat liver. J.Hepatol. 1985; 1(-6-):629-638. >>> Insulin; SC; rat; 2001; 3 days; replacement therapy (streptozotocin induced diabetes); peptides.

P0738 Locatelli,V., Miyoshi,H., Bestetti,G., Rossi,G.L., Muller,E.E. Effect of growth hormone-releasing stimuli in streptozotocin diabetic rats. Brain Research 1985; 341(--):35-40. >>> Insulin; Glycerol; SC; rat; 2001; 1 month; mp replaced every week; peptides; replacement therapy (streptozotocin induced diabetes).

P0727 Gavin,L.A., McMahon,F., Moeller,M. Modulation of adipose lipoprotein lipase by thyroid hormone and diabetes. Diabetes 1985; 34(--):1266-1271. >>> Insulin; Triiodothyronine; SC; rat; 2001; 72 hours; replacement therapy (thyroidectomy, streptozocin induced diabetes); peptides.

P0722 Berti-Mattera,L., Peterson,R., Bell,M., Eichberg,J. Effect of hyperglycemia and its prevention by insulin treatment on the incorporation of 32P into polyphosphoinositides and other phospholipids in peripheral nerve of the streptozotocin diabetic rat. J.Neurochem. 1985; 45(--):1692-1698. >>> Insulin; Saline; SC; rat; 8 weeks; long-term study; replacement therapy (streptozotocin induced diabetes); controls received mp w/ vehicle; peptides.