References on the Administration of Dopaminergic Agonists and Antagonists Using ALZET® Osmotic Pumps

1. Apomorphine

15155 Yan, T.T., Xiong, W.W., Huang, F.R., Zheng, F., Ying, H.F., Chen, J.F., Qu, J., Zhou, X.T., Zhou, X.T. Daily Injection But Not Continuous Infusion of Apomorphine Inhibits Form-Deprivation Myopia in Mice. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2015; 56(--):2475-2485. >>> Apomorphine; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57Bl6, 4 weeks old); functionality of mp verified by residual volume; pumps replaced every 2 weeks; comparison of injection vs mp;.

11030 Sarkis, R., Saade, N., Atweh, S., Jabbur, S., Al-Amin, H. Chronic dizocilpine or apomorphine and development of neuropathy in two rat models I: Behavioral effects and role of nucleus accumbens. Experimental Neurology 2011; 228(-1-):19-29. >>> MK-801; apomorphine HCL hemihydrate; Saline; ascorbic acid; CSF/CNS (nucleus accumbens); Rat; 2002; Controls received mp w/ vehicle; animal info (adult, female, Sprague Dawley, 200-300 g); post op. care (dexamethasone injections to prevent brain edema); behavioral testing (mechanical allodynia, Paw withdrawal latency, cold allodynia, hotplate test, spontaneous motor activity); cannula placement verified by picomicrograph of brain section; CCI, chronic constriction injury; SNI, spared nerve injury.

7105 Fornai, F., Schlueter, O.M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C.L., Pontarelli, F., Battaglia, G., Pellegrini, A., Nicoletti, F., Ruggieri, S., Paparelli, A., Suedhof, T.C. Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and alpha-synuclein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005; 102(-9-):3413-3418. >>> MPTP; L-dopa; apomorphine; IP; SC; Mice; 2004; Controls received mp w/ saline; comparison of IP injections vs. mp; neurodegenerative (Parkinson's disease); L-dopa and apomorphine group had SC implanted pumps; route is unclear for the MPTP group;"Continuous MPTP infusions thus recreate a disease state that mimics human PD better than acute MPTP bolus injections."(p. 3417); MPTP group received IP pumps (2004 model), verified by e-mailing author.

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2. Bromocriptine

7660 Leonard, S.T., izadeh-Naderi, R., Stokes, K., Ferkin, M.H. The role of prolactin and testosterone in mediating seasonal differences in the self-grooming behavior of male meadow voles, Microtus pennsylvanicus. PHYSIOLOGY&BEHAVIOR 2005; 85(-4-):461-468. >>> Bromocriptine; prolactin, ovine; Saline, sterile; SC; Prairie vole; 2004; Controls received mp w/ vehicle; replacement therapy (gonadectomy); animal info (male, meadow); animals also received testosterone via silastic implant at same time.

7349 Brooks, P.L., Vella, E.T., Wynne-Edwards, K.E. Dopamine agonist treatment before and after the birth reduces prolactin concentration but does not impair paternal responsiveness in Djungarian hamsters Phodopus campbelli. Hormones and Behavior 2005; 47(-3-):358-366. >>> Bromocriptine; Saline, isotonic; ethanol; tartaric acid; SC; Hamster; 1003D; Controls received mp w/ vehicle; comparison of SC injections vs. mp; 10% ethanol; mp primed in 37 degrees celsius saline for>4 hours; wound clips used.

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3. Dinapsoline

4902 Gulwadi, A.G., Korpinen, C.D., Mailman, R.B., Nichols, D.E., Sit, S.Y., Taber, M.T. Dinapsoline: Characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease.. Journal of Pharmacology and Experimental Therapeutics 2001; 296(-2-):338-344. >>> Dinapsoline; DMSO; ascorbic acid; CSF/CNS; Rat; 2ML2; Controls received mp w/ vehicle; neurodegenerative (Parkinson's disease); vehicle used was 50% DMSO, 12.5% ascorbic acid; dinapsoline is a potent D1 dopamine receptor agonist.

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4. Domperidone

8453 Craven, A.J., Nixon, A.J., Ashby, M.G., Ormandy, C.J., Blazek, K., Wilkins, R.J., Pearson, A.J. Prolactin delays hair regrowth in mice. Journal of Endocrinology 2006; 191(-2-):415-425. >>> Prolactin, ovine; domperidone; Sodium bicarbonate buffer; PEG 400; SC; Mice; 1003D; 1007D; 1002; Controls received no treatment; functionality of mp verified by plasma prolactin levels; animal info (Balb/c, 18-30 days old).

7464 Kippin, T.E., Kapur, S., van der Kooy, D. Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. Journal of Neuroscience 2005; 25(-24-):5815-5823. >>> Haloperidol; domperidone; water, distilled; saline; SC; Rat; mice; 1002; 2ML2; 2ML4; Controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; dose-response (fig. 1); comparison of ip injections vs. mp; dopamine D2 receptor antagonist.

3701 Martinelli, G.P., Liu, H., Clarke, W.P., Heisenleder, D.J., Knight, R.J. Prolactin suppression enhances the effects of perioperative donor-specific blood transfusions on graft survival. J. Surg. Res 1996; 64(--):190-197. >>> Bromocriptine; Domperidone; PEG 400; SC; rat; 2ML2; controls received mp w/ PEG; immunology.

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5. Dopamine

14575 Wedel, J., Weij, M., Smit-van Oosten, A., Hillebrands, J.L., Hillebrands, J.L. Simultaneous subcutaneous implantation of two osmotic minipumps connected to a jugular vein catheter in the rat. Laboratory Animals 2014; 48(--):338-341. >>> Dopamine, N-octanoyl; Tween 80; saline; IV (jugular); Rat; 2ML4; animal info (male, Brown Norway, 230-270 g, female, Wistar, 280-310 g); good methods;"Our data show that double pump implantation is a feasible alternative to changing pumps or the use of extracorporeal pump systems connected via a long wire to partly restrained animals."pg 338; N-octanoyl-dopamine also known as NOD; multiple pumps (2) used; two pumps connected to Y connector, in-house made Y-tube;"we showed that the simultaneous implantation of two slow-flow rate osmotic pumps connected to a jugular vein catheter is feasible and is not linked to additional signs of discomfort compared with single pump-implanted rats."pg 341.

10346 Leblois, A., Wendel, B.J., Perkel, D.J. Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors. Journal of Neuroscience 2010; 30(-16-):5730-5743. >>> Dopamine; SCH23390; Saline; CSF/CNS (area X); Bird (zebra finch); 1002; Controls received mp w/ vehicle; good methods (pg 5731); ALZET brain infusion kit used; animal info (adult, male); Y-connector used; pump externalized with a backpack; pump placed inside microcentrifuge tube; cannula placement verified by histological examination.

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6. Dopexamine

6743 Oberbeck, R., Schmitz, D., Schueler, M., Wilsenack, K., Schedlowski, M., Exton, M. Dopexamine and cellular immune functions during systemic inflammation. Immunobiology 2004; 208(-5-):429-438. >>> Dopexamine; dopamine; IP; Mice; Controls received saline&sham operation; immunology; polymicrobial sepsis induced cecal ligation&puncture (CLP).

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7. Fenoldopam

16299 Borcherding, D. C., Tong, W., Hugo, E. R., Barnard, D. F., Fox, S., LaSance, K., Shaughnessy, E., Ben-Jonathan, N. Expression and therapeutic targeting of dopamine receptor-1 (D1R) in breast cancer. Oncogene 2016; 35(-24-):3103-13. >>> Fenoldopam; PBS; SC; mice; 1004; Controls received mp w/ vehicle; animal info (Eight-week-old female athymic nu/nu mice; inoculated with MDA-MB-231 cells or SUM159 cells); functionality of mp verified by measurement of tumor volumes; cancer (breast cancer); dose-response (pg. 3109); Xenograft models; Dose (400 ng/kg/min or 133 ng/kg/min);.

9922 Zhang, M.Z., Yao, B., Fang, X.F., Wang, S.W., Smith, J.P., Harris, R.C. Intrarenal Dopaminergic System Regulates Renin Expression. Hypertension 2009; 53(-3-):564-570. >>> Fenoldopam; SC; Rat; 2001; Animal info (male, Sprague Dawley, 4-6 wks old).

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8. Haloperidol

16217 Oda, Y., Tadokoro, S., Takase, M., Kanahara, N., Watanabe, H., Shirayama, Y., Hashimoto, K., Iyo, M. G protein-coupled receptor kinase 6/beta-arrestin 2 system in a rat model of dopamine supersensitivity psychosis. J Psychopharmacol 2015; 29(-12-):1308-13. >>> Haloperidol; Acetic acid, glacial; water; SC; rat; 2ML2; Controls received mp w/ vehicle; animal info (Eleven-week-old male Wistar rats, 240–260 g ); functionality of mp verified by ELIZA testing; 2% acetic acid used; good methods (pg 1309); stress/adverse reaction: “One animal did not recover from pump-implanting surgery and was excluded from analysis” (see pg. 1310); behavioral testing (MAP-induced locomotion test); Vehicle pH adjusted to 3.6-3.8 with NaOH; 9mm wound clips used; Dose (0.75 mg/kg/d;);.

16116 El Hage, C., Bedard, A. M., Samaha, A. N. Antipsychotic treatment leading to dopamine supersensitivity persistently alters nucleus accumbens function. Neuropharmacology 2015; 99(--):715-25. >>> Haloperidol; Olanzapine; Acetic acid; water; SC; rat; 2ML2; Controls received sham surgery; animal info: Male Sprague-Dawley rats; %0.5 or %2 of acetic acid; behavioral testing (trained to associate the delivery of 100 ml water (the unconditioned stimulus; UCS) into a receptacle with a light/tone conditioned stimulus (CS)); Dose: 0.5 mg/kg/day (haloperidol); 10 mg/kg/day (olanzapine).

16105 Charron, A., Hage, C. E., Servonnet, A., Samaha, A. N. 5-HT2 receptors modulate the expression of antipsychotic-induced dopamine supersensitivity. Eur Neuropsychopharmacol 2015; 25(-12-):2381-93. >>> Haloperidol; Acetic acid, glacial; water; SC; rat; 2ML2; Controls received sham surgery consisting of an incision and sutures; animal info: Male Sprague-Dawley rats 200–225g; water (pH 5) used; half-life (p. 2383 ), 1.5 hours; models the kinetics of standard antipsychotic treatment in patients; Dose: 0.5 mg/ kg/day.

16002 Madularu, D., Kulkarni, P., Ferris, C. F., Brake, W. G. Changes in brain volume in response to estradiol levels, amphetamine sensitization and haloperidol treatment in awake female rats. Brain Res 2015; 1618(--):100-10. >>> Haloperidol; SC; Rat; 2002; Controls received sham surgery; animal info (female, Sprague Dawley, 200-250g 2-3 months old, OVX); post op. care (Anafen 0.1 mL/rat; antibiotic ointment); MRI; PEEK; Dose (0.25 mg/kg/day);.

14740 Gao, J., Li, M., Li, M. Differential effects of intermittent versus continuous haloperidol treatment throughout adolescence on haloperidol sensitization and social behavior in adulthood. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2014; 54(--):67-75. >>> Haloperidol; Water, sterile; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, PND44-71); comparison of injection vs mp; post op. care (incision cleaned with 75% ethanol); behavioral testing (two-way avoidance conditioning apparatus; locomotor activity monitoring apparatus; avoidance training); dependence; used 9mm wound clips; pumps wiped with 75% ethanol; pumps removed after 28 days;.

14662 Anderson, P.M., Pinault, D., O'Brien, T.J., Jones, N.C., Jones, N.C. Chronic administration of antipsychotics attenuates ongoing and ketamine-induced increases in cortical gamma oscillations. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 2014; 17(--):1895-1904. >>> Haloperidol; clozapine; LY379268; Saline; acetic acid; water, sterile; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Wistar, 10-12 weeks old, 250-350g); functionality of mp verified by residual volume; behavioral testing (locomotor activity); LY379268 is a metabotropic glutamate 2/3 receptor agonist (mGluR 2/3);.

13606 Madularu, D., Shams, W.M., Brake, W.G. Estrogen potentiates the behavioral and nucleus accumbens dopamine response to continuous haloperidol treatment in female rats. European Journal of Neuroscience 2014; 39(-2-):257-265. >>> Haloperidol; Saline; SC; Rat; 2002; Animal info (female, Sprague Dawley, ovariectomized); behavioral testing (motor activity); replacement therapy (ovariectomized); pump removed after 12 days;.

13590 Cazorla, M., de Carvalho, F.D., Chohan, M.O., Shegda, M., Chuhma, N., Rayport, S., Ahmari, S.E., Moore, H., Kellendonk, C. Dopamine D2 Receptors Regulate the Anatomical and Functional Balance of Basal Ganglia Circuitry. Neuron 2014; 81(-1-):153-164. >>> Haloperidol; Lactic acid; sodium hydroxide; SC; Mice (transgenic); 2002; Controls received mp w/ vehicle; animal info (male, D2R-OE, adult); behavioral testing (open field, locomotor activity);.

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9. L-DOPA

Q0502 Lebel,M., Chagniel,L., Bureau,G., Cyr,M. Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat. NEUROBIOLOGY OF DISEASE 2010; 38(-1-):59-67. >>> L-DOPA; CSF/CNS (striatum); Rat; 2004; 2ML1; 2ML4; 21 days; Controls received mp w/ vehicle; pumps replaced every week; cyanoacrylate adhesive; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley).

P9062 Kaeaeriaeinen,T.M., Garcia-Horsman,J.A., Piltonen,M., Huotari,M., Maennistoe,P.T. Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral Nigral lesions. BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 2008; 102(-3-):300-307. >>> L-DOPA; NaCl, isotonic; ascorbic acid; CSF/CNS (striatum); Rat; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig.2, pg. 302); animal info (male, Wistar, 190-230 g.); pumps incubated at 37 degree Celsius overnight in isotonic saline; behavioral (rotational behavioral); neurodegenerative (Parkinson's Disease).

P7751 Bilbao,G., Ruiz-Ortega,J.A., Miguens,N., Ulibarri,I., Linazasoro,G., Gomez-Urquijo,S., Garibi,J., Ugedo,L. Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: Effects of subthalamotomy and levodopa treatment. Brain Research 2006; 1084(--):175-184. >>> L-DOPA; benserazide; Water, distilled; SC; Rat; 2ML2; 14 days; Enzyme inhibitor (dopadecarboxylase); neurodegenerative (Parkinson's disease); animal info (male, albino Sprague-Dawley, 150-175g); nigrostriatal pathway lesions.

P6896 Fornai,F., Schlueter,O.M., Lenzi,P., Gesi,M., Ruffoli,R., Ferrucci,M., Lazzeri,G., Busceti,C.L., Pontarelli,F., Battaglia,G., Pellegrini,A., Nicoletti,F., Ruggieri,S., Paparelli,A., Suedhof,T.C. Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and alpha-synuclein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005; 102(-9-):3413-3418. >>> MPTP; L-dopa; apomorphine; IP; SC; Mice; 2004; 1-28 days; Controls received mp w/ saline; comparison of IP injections vs. mp; neurodegenerative (Parkinson's disease); L-dopa and apomorphine group had SC implanted pumps; route is unclear for the MPTP group; "Continuous MPTP infusions thus recreate a disease state that mimics human PD better than acute MPTP bolus injections." (p. 3417); MPTP group received IP pumps (2004 model), verified by e-mailing author.

P6820 Hoglinger,G.U., Rizk,P., Muriel,M.P., Duyckaerts,C., Oertel,W.H., Caille,I., Hirsch,E.C. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nature Neuroscience 2004; 7(-7-):726-735. >>> L-DOPA, methyl ester; Benserazide; ascorbic acid; SC; Rat; 2ML4; 3 weeks; Neurodegenerative (Parkinson's disease).

P5969 Kemmerer,E.S., Desmond,T.J., Albin,R.L., Kilbourn,M.R., Frey,K.A. Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole. Experimental Neurology 2003; 183(-1-):81-86. >>> L-DOPA; benserazide; prazosin; IP; Rat; 2ML4; 4 weeks; Neurodegenerative (Parkinson's disease).

P5834 Caprile,T., Hein,S., Rodriguez,S., Montecinos,H., Rodriguez,E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. MOLECULAR BRAIN RESEARCH 2003; 110(-2-):177-192. >>> Serotonin, binoxaiate; Norepinephrine; serotonin trifluoroacetate; Serotonin creatinin sulfate; L-DOPA; CSF, artificial; radio-isotopes; 3H tracer; CSF/CNS; Rat; 2001; 7 days.

P3515 Trugman,J.M., Hubbard,C.A., Bennett Jr,J.P. Dose-related effects of continuous levodopa infusion in rats with unilateral lesions of the substantia nigra. Brain Research 1996; 725(--):177-183. >>> L-DOPA methyl ester; Benserazide; Water; SC; rat; 2001D; 22 hours; dose response; comparison of injections vs. mp made based upon published studies administering L-dopa by injection.

P3178 Vander Borght,T., Kilbourn,M., Desmond,T., Kuhl,D., Frey,K. The vesicular monoamine transporter is not regulated by dopaminergic drug treatments. Eur.J.Pharmacol. 1995; 294(--):577-583. >>> Apomorphine; L-DOPA methyl ester; Benserazide; Tetrabenazine; Ascorbic acid; Propylene glycol; SC; rat; 2ML2; 2 weeks; controls received mp with propylene glycol; 2 mps used to deliver apomorphine.

P2582 Inglis,G.C., Kenyon,C.J. Effects of long-term infusions of dopa and carbidopa on renin and steroid secretion in the rat. Endocrinology 1992; 131(-6-):2941-2945. >>> L-DOPA; Carbidopa; HCl; SC; rat; 2002; 2 weeks; controls received mp w/ vehicle; agents given separately and together.

P2252 Engber,T.M., Susel,Z., Kuo,S., Gerfen,C.R., Chase,T.N. Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats. Brain Research 1991; 552(-1-):113-118. >>> L-DOPA; Benserazide; Saline; IP; rat; 2ML2; 21 days; controls received mp w/saline; functionality of mp verified upon removal; comparison of intermittent IP injections vs mp.

P1800 Engber,T.M., Susel,Z., Kuo,S., Chase,T.N. Chronic levodopa treatment alters basal and dopamine agonist-stimulated cerebral glucose utilization. J.Neurosci. 1990; 10(-2-):3889-3895. >>> L-DOPA; IP; rat; 2ML2; 19 days; dose-response (table, p. 3892); comparison of bid injections vs. mp; 'levodopa replacement by continuous infusion may be more physiological than oral intermittent therapy.' (p. 3895).

P1648 Engber,T.M., Susel,Z., Juncos,J.L., Chase,T.N. Continuous and intermittent levodopa differentially affect rotation induced by D-1 and D-2 dopamine agonists. Eur.J.Pharmacol. 1989; 168(--):291-298. >>> L-DOPA; IP; rat; 19 days; functionality of mp verified by blood levels; comparison of IP injections b.i.d. vs. mp.

P0740 Stromberg,I., Herrera-Marschitz,M., Ungerstedt,U., Ebendal,T., Olson,L. Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp.Brain Research 1985; 60(-2-):335-349. >>> Dopamine; L-DOPA; Nerve growth factor; Saline; CSF/CNS (corpus striatum); rat; 2002; 28 days; comparison of injections vs. mp infusion; mp replaced after 14 days; mp connected to cannula in striatum mounted w/dialysis fiber; l-dopa&dopamine used only to test fiber; 6-OHDA lesions.

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10. L-dopa

10751 Lebel, M., Chagniel, L., Bureau, G., Cyr, M. Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat. NEUROBIOLOGY OF DISEASE 2010; 38(-1-):59-67. >>> L-DOPA; CSF/CNS (striatum); Rat; 2004; 2ML1; 2ML4; Controls received mp w/ vehicle; pumps replaced every week; cyanoacrylate adhesive; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley).

9297 Kaeaeriaeinen, T.M., Garcia-Horsman, J.A., Piltonen, M., Huotari, M., Maennistoe, P.T. Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral Nigral lesions. BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 2008; 102(-3-):300-307. >>> L-DOPA; NaCl, isotonic; ascorbic acid; CSF/CNS (striatum); Rat; 2002; Controls received mp w/ vehicle; dose-response (fig.2, pg. 302); animal info (male, Wistar, 190-230 g.); pumps incubated at 37 degree Celsius overnight in isotonic saline; behavioral (rotational behavioral); neurodegenerative (Parkinson's Disease).

7967 Bilbao, G., Ruiz-Ortega, J.A., Miguens, N., Ulibarri, I., Linazasoro, G., Gomez-Urquijo, S., Garibi, J., Ugedo, L. Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: Effects of subthalamotomy and levodopa treatment. Brain Research 2006; 1084(--):175-184. >>> L-DOPA; benserazide; Water, distilled; SC; Rat; 2ML2; Enzyme inhibitor (dopadecarboxylase); neurodegenerative (Parkinson's disease); animal info (male, albino Sprague-Dawley, 150-175g); nigrostriatal pathway lesions.

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11. Lisuride

12259 Zweckberger, K., Simunovic, F., Kiening, K.L., Unterberg, A.W., Sakowitz, O.W. Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. Neuroscience Letters 2011; 499(-3-):189-193. >>> Lisuride; Hydrogen maleate; SC; Rat; 2ML1; Animal info (Sprague Dawley, male, 350-380 g).

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12. Metoclopramide

391 Aguilera, G., Catt, K.J. Dopaminergic modulation of aldosterone secretion in the rat. Endocrinology 1984; 114(-1-):176-181. >>> Angiotensin II; Dopamine; Metoclopramide; IP; IV; rat; simultaneous administration of MCP (iv) w/ AII (ip), and MCP (iv) w/ DOP (iv); MCP and AII also infused alone, all by mp; peptides.

124 Chan, V., Katikineni, M., Davies, T.F., Catt, K.J. Hormonal regulation of testicular luteinizing hormone and prolactin receptors. Endocrinology 1981; 108(-5-):1607-1612. >>> Metoclopramide; IP; rat; no comment posted.

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13. NNC-756

2576 Glenthoj, B., Bolwig, T.G., Hemmingsen, R. Effects of chronic discontinuous and continuous treatment of rats with a dopamine D receptor antagonist (NNC-756). Eur. J. Pharmacol 1993; 242(--):283-291. >>> NNC-756; Acetic acid; Water; SC; rat; 2002; comparison of Q week injections vs. mp; long-term study, pumps replaced every 2 weeks; dopamine receptor antagonist.

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14. Nafadotride

P3446 Azaryan,A.V., Clock,B.J., Cox,B.M. Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation. Neurochem.Res. 1996; 21(-11-):1411-1415. >>> Hydrobromide, R(+)-6-bromo-APB-SKF-38393; Nafadotride, (5)-bromocriptine; Cocaine HCl; Saline; rat; 2ML1; 3 days; controls received mp w/ saline.

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15. Nafadotride, (5)-bromocriptine-

P3446 Azaryan,A.V., Clock,B.J., Cox,B.M. Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation. Neurochem.Res. 1996; 21(-11-):1411-1415. >>> Hydrobromide, R(+)-6-bromo-APB-SKF-38393; Nafadotride, (5)-bromocriptine; Cocaine HCl; Saline; rat; 2ML1; 3 days; controls received mp w/ saline.

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16. Other (NNC-756, SCH-23390, Spiperone)

Q0202 Yao,B., Harris,R.C., Zhang,M.Z. Intrarenal Dopamine Attenuates Deoxycorticosterone Acetate/High Salt-Induced Blood Pressure Elevation in Part Through Activation of a Medullary Cyclooxygenase 2 Pathway. Hypertension 2009; 54(-5-):1077-1083. >>> SCH-23390; SC; Mice; 2004; ; Animal info (wt, COMT -/-); SCH-23390 is a D1-like receptor agonist.

Q0098 Leblois,A., Wendel,B.J., Perkel,D.J. Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors. Journal of Neuroscience 2010; 30(-16-):5730-5743. >>> Dopamine; SCH23390; Saline; CSF/CNS (area X); Bird (zebra finch); 1002; ; Controls received mp w/ vehicle; good methods (pg 5731); ALZET brain infusion kit used; animal info (adult, male); Y connector used; pump externalized with a backpack; pump placed inside microcentrifuge tube; cannula placement verified by histological examination.

P8591 Shippenberg,T.S., Herz,A. Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of mu-and kappa-opioid agonists. Brain Res 1987; 436(-1-):169-172. >>> SCH 23390; Water; DMSO; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 140-160 grams); D1 dopamine receptor antagonist, 30% DMSO used.

P5474 Byrnes,E.M., Rigero,B.A., Bridges,R.S. Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats. Pharmacology Biochemistry and Behavior 2002; 73(-4-):869-875. >>> SCH-23390; DMSO; water, sterile; SC; Rat; 2001; ; Controls received mp w/ vehicle; agent is a D1-like antagonist.

P4367 Davidoff,S.A., Chu,H.M., Benes,F.M. Acute administration of SCH23390 increases D1 receptors on nonpyramidal neurons in rat mPFC. Synapse 2000; 35(--):173-181. >>> SCH-23390; Saline, normal; SC; rat; 1003D; 48 hours; controls received mp with vehicle.

P3341 Suzuki,T., Funada,M., Narita,M., Misawa,M., Nagase,H. Morphine-induced place preference in the CXBK mouse: characteristics of u opioid receptor subtypes. Brain Research 1993; 602(--):45-52. >>> SCH-23390; DMSO; Water; SC; mice; 2001; no duration posted; controls received mp w/vehicle; pump implanted in flank.

P3313 Azaryan,A.V., Coughlin,L.J., Buzas,B., Clock,B.J., Cox,B.M. Effect of chronic cocaine treatment on m- and d-opioid receptor mRNA levels in dopaminergically innervated brain regions. J.Neurochem. 1996; 66(--):443-448. >>> Cocaine HCl; Eticlopride; SCH-23390; Saline; SC; rat; 2001; 3 days; controls received mp w/saline; eticlopride is a D1&D2 receptor antagonist.

P2611 Alberch,J., Arenas,E., Perez-Navarro,E., Marsal,J. Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons. Naunyn-Schmiedeberg's Arch.Pharmacol. 1993; 348(--):445-449. >>> Haloperidol; SCH-23390; SC; rat; 14 days; controls received mp w/ saline.

P2489 Glenthoj,B., Bolwig,T.G., Hemmingsen,R. Effects of chronic discontinuous and continuous treatment of rats with a dopamine D receptor antagonist (NNC-756). Eur.J.Pharmacol. 1993; 242(--):283-291. >>> NNC-756; Acetic acid; Water; SC; rat; 2002; 15 weeks; comparison of Q week injections vs. mp; long-term study, pumps replaced every 2 weeks; dopamine receptor antagonist.

P2436 Srinivasan,M., Yamamoto,Y., Brodin,E., Persson,H. Chronic treatment with SCH-23390, a selective dopamine D1 receptor blocker decreases preprotachykinin-A mRNA levels in nucleus tractus solitarii of the rabbit: role in respiratory control. Mol.Brain Research 1991; 9(-3-):233-238. >>> SCH-23390; Glucose; Lactic acid; Sodium hydroxide; SC; rabbit; 2002; 14 days; peptides.

P2318 Howell,L.L., Byrd,L.D. Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey. J.Pharmacol.Exp.Ther. 1992; 262(-3-):907-915. >>> Raclopride tartrate; SCH-23390; Saline; Alcohol; SC; monkey; 2002; 14 days; controls received mp w/ saline.

P2185 Burger,L.Y., Martin-Iverson,M.T. Day/night differences in D1 but not D2 DA receptor protection from EEDQ denaturation in rats treated with continuous cocaine. Synapse 1993; 13(--):20-29. >>> SCH-23390; Cocaine HCl; Raclopride; Water; SC; rat; 2ML2; 14 days; no comment posted.

P1288 Shippenberg,T.S., Herz,A. Motivational effects of opioids; influence of D-1 versus D-2 receptors antagonists. Eur.J.Pharmacol. 1988; 151(--):233-242. >>> Spiperone; SCH-23390; DMSO; Water; SC; rat; 2001; 2ML1; 7 days; functionality of mp verified after delivery; dopamine antagonist.

P1233 Martin-Iverson,M.T., Iverson,S.D., Stahl,S.M. Long-term motor stimulant effects of (+) -4-propyl-9-hydroxynaphthoxazine (PHNO), a dopamine D-2 receptor agonist: interactions with a dopamine D-1 receptor antagonist and agonist. Eur.J.Pharmacol. 1988; 149(--):25-31. >>> Hydroxynaphthoxacine, 4-propyl-9-; SCH-23390; Water; SC; rat; 2002; 11 days; controls received mp w/water; multiple pumps per animal (2); separate and simultaneous infusion of agents; PHNO is a dopamine antagonist.

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17. PHNO

5387 Ruzich, M., Martin-Iverson, M.T. Pinealectomy blocks stress-induced motor stimulation but not sensitization and tolerance to a dopamine D2 receptor agonist. Psychopharmacology (Berl) 2000; 152(-3-):275-282. >>> Hydroxynaphthoxacine, 4-propyl-9-; Water, distilled; SC; Rat; 2002; Controls received mp w/ vehicle; good methods (p.276-77); tolerance; PHNO is a selective dopamine D2 receptor agonist;"The advantages of using a continuous drug regimen are that sensitization and tolerance are produced independently of the confounding influences..."(p.275).

4641 Munro, J.D, Martin-Iverson, M.T. Circadian rhythm-dependent development of melatonin effects and tolerance to PHNO in rats.. Pharmacology Biochemistry and Behavior 2000; 65(-3-):495-501. >>> Hydroxynaphthoxacine, 4-propyl-9-;; Water, distilled;; SC;; rat;; 2002;; controls received mp w/vehicle; tolerance; PHNO is a selective dopamine D2 receptor agonist.

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18. Pergolide

2800 de Yebenes, J.G., Fahn, S., Lovelle, S., Jackson-Lewis, V., Jorge, P., Mena, M.A., Reiriz, J., Bustos, J.C., Magarinos, C., Martinez, A. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. Movement Disorders 1987; 2(-3-):143-158. >>> Dopamine; Pargyline; Deprenyl; Lisuride; Pergolide; HCl; Sodium metabisulfate; CSF/CNS; rat; 2001; controls received mp with vehicles; replacement therapy (lesion in dopamine pathway); stability verified for 1 week by measuring dopamine concentrations and its metabolites at varying time intervals with HPLC; concomitant dopamine infusion w/ pargyline and w/ deprenyl; antihypertensive; neurodegenerative (Parkinson's disease).

1445 Garcia de Yebenes, J., Fahn, S., Mena, M.A., Pardo, B., Casarejos, M.J. Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. ASAIO Transactions 1988; 34(--):951-957. >>> Dopamine; Lisuride; Pergolide; Hydroxynaphthoxacine, 4-propyl-9-; HCl; Water; CSF/CNS; rat; PHNO is dopamine D-2 receptor agonist;.

1313 de Yebenes, J.G., Fahn, S., Jackson-Lewis, V., Jorge, P., Mena, M.A., Reiriz, J. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. J. Neural Transm 1988; 27(--):141-160. >>> Deprenyl; Dopamine; Lisuride; Pargyline; Pergolide; HCl; Sodium metabisulfite; Water; CSF/CNS; rat; 2001; mp connected to cannula; stability of DA verified in several vehicles, p 146; concomitant DA infusion with pargyline; DA infusion with deprenyl; replacement therapy (dopamine deficiency); stability verified in vitro; antihypertensive; neurodegenerative (Parkinson's disease).

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19. Pramipexole

12052 Chernoloz, O., El Mansari, M., Blier, P. Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain. JOURNAL OF PSYCHIATRY&NEUROSCIENCE 2012; 37(-2-):113-121. >>> Pramipexole; SC; Rat; Controls received mp w/ physiologic saline; animal info (Sprague Dawley, male, 270-320 g).

10340 Ferger, B., Buck, K., Shimasaki, M., Koros, E., Voehringer, P., Buerger, E. Continuous Dopaminergic Stimulation by Pramipexole Is Effective to Treat Early Morning Akinesia in Animal Models of Parkinson's Disease: A Pharmacokinetic-Pharmacodynamic Study Using in Vivo Microdialysis in Rats. Synapse 2010; 64(-7-):533-541. >>> Pramipexole; Saline; SC; Rat; 1007D; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 250-300 g.); comparison of SC injections vs mp; neurodegenerative (Parkinson's Disease);"...this study highlights the potential benefit of CDS (continuous dopaminergic stimulation) using PPX-CR and the advantage over PPX-IR in two symptomatic PD models"pg 540; half-life"long"pg 534; haloperidol-induced catalepsy; pk study.

10150 Chernoloz, O., El Mansari, M., Blier, P. Sustained Administration of Pramipexole Modifies the Spontaneous Firing of Dopamine, Norepinephrine, and Serotonin Neurons in the Rat Brain. Neuropsychopharmacology 2009; 34(-3-):651-661. >>> Pramipexole; SC; Rat; Controls received mp w/saline, physiological; animal info (male, Sprague Dawley, 270-320 g).

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20. Quinpirole

14700 Cobacho, N., de la Calle, J.L., Paino, C.L., Paino, C.L. Dopaminergic modulation of neuropathic pain: Analgesia in rats by a D2-type receptor agonist. Brain Research Bulletin 2014; 106(--):62-71. >>> Quinpirole hydrochloride; Water, sterile; SC; Rat; 2ML1; Controls received sham mp; animal info (male, Sprague Dawley, adult, 250-300g); functionality of mp verified by incubating pumps after explantation in 37C saline and noted collected amount of fluid - post explantation in vitro testing; behavioral testing (tactile and cold allodynia); neuropathic pain; pumps primed in 37C saline for 2 hours;.

11855 Hood, S., Cassidy, P., Cossette, M.P., Weigl, Y., Verwey, M., Robinson, B., Stewart, J., Amir, S. Endogenous Dopamine Regulates the Rhythm of Expression of the Clock Protein PER2 in the Rat Dorsal Striatum via Daily Activation of D(2) Dopamine Receptors. Journal of Neuroscience 2010; 30(-42-):14046-14058. >>> SCH23390; raclopride; quinpirole; SKF 81297; Water, distilled; SC; Rat; 2ML2; Controls received sham surgery; animal info (Wistar, male, 180-210 g); SCH23390 is a D1DA receptor antagonist; raclopride is a D2Da receptor antagonist; wound clips used.

10970 Aumann, T.D., Egan, K., Lim, J., Boon, W.C., Bye, C.R., Chua, H.K., Baban, N., Parish, C.L., Bobrovskaya, L., Dickson, P., Horne, M.K. Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons. Journal of Neurochemistry 2011; 116(-4-):646-658. >>> Apamin; muscimol; quinpirole; riluzole; FPL64176; nimodipine; picrotoxin; benzimidazolinone; CSF/CNS (midbrain); CSF/CNS (dorsal striatum); Mice; 1002; Animal info (eight-week-old, C57BL6/J, male); ALZET brain infusion kit 1 used; neurodegenerative (Parkinson's disease).

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21. Remoxipride

P2736 Georgieva,J., Mohringe,B., Magnusson,O. Neurochemical effects of prolonged treatment with remoxipride as assessed by intracerebral microdialysis in freely moving rats. Prog.Neuro-Psychopharmacol.Biol.Psychiat. 1994; 18(--):1187-1201. >>> Remoxipride HCl; Sodium chloride; SC; rat; 2002; 14 days; controls received sodium chloride; functionality of mp verified by checking blood levels of drug and determining residual drug amount; comparison of sc injections vs mp; remoxipride is an antipsychotic drug.

P2204 Ericson,H., Ross,S.B. Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain. Eur.J.Pharmacol.- Mol.Pharmacol.Sect. 1992; 226(--):157-161. >>> Remoxipride HCl; Haloperidol; Water; Acetic acid; SC; rat; 3,14 days; controls received sham operations.

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22. Remoxipride HCL

2828 Georgieva, J., Mohringe, B., Magnusson, O. Neurochemical effects of prolonged treatment with remoxipride as assessed by intracerebral microdialysis in freely moving rats. Prog. Neuro-Psychopharmacol. Biol. Psychiat 1994; 18(--):1187-1201. >>> Remoxipride HCl; Sodium chloride; SC; rat; 2002; controls received sodium chloride; functionality of mp verified by checking blood levels of drug and determining residual drug amount; comparison of sc injections vs mp; remoxipride is an antipsychotic drug.

2195 Ericson, H., Ross, S.B. Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain. Eur. J. Pharmacol. - Mol. Pharmacol. Sect 1992; 226(--):157-161. >>> Remoxipride HCl; Haloperidol; Water; Acetic acid; SC; rat; controls received sham operations.

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23. SCH-23390

10450 Yao, B., Harris, R.C., Zhang, M.Z. Intrarenal Dopamine Attenuates Deoxycorticosterone Acetate/High Salt-Induced Blood Pressure Elevation in Part Through Activation of a Medullary Cyclooxygenase 2 Pathway. Hypertension 2009; 54(-5-):1077-1083. >>> SCH-23390; SC; Mice; 2004; Animal info (wt, COMT -/-); SCH-23390 is a D1-like receptor agonist.

5612 Byrnes, E.M., Rigero, B.A., Bridges, R.S. Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats. Pharmacology Biochemistry and Behavior 2002; 73(-4-):869-875. >>> SCH-23390; DMSO; water, sterile; SC; Rat; 2001; Controls received mp w/ vehicle; agent is a D1-like antagonist.

4469 Davidoff, S.A., Chu, H.M., Benes, F.M. Acute administration of SCH23390 increases D1 receptors on nonpyramidal neurons in rat mPFC. Synapse 2000; 35(--):173-181. >>> SCH-23390; Saline, normal; SC; rat; 1003D; controls received mp with vehicle.

3449 Suzuki, T., Funada, M., Narita, M., Misawa, M., Nagase, H. Morphine-induced place preference in the CXBK mouse: characteristics of u opioid receptor subtypes. Brain Research 1993; 602(--):45-52. >>> SCH-23390; DMSO; Water; SC; mice; 2001; controls received mp w/vehicle; pump implanted in flank.

3421 Azaryan, A.V., Coughlin, L.J., Buzas, B., Clock, B.J., Cox, B.M. Effect of chronic cocaine treatment on m- and d-opioid receptor mRNA levels in dopaminergically innervated brain regions. J. Neurochem 1996; 66(--):443-448. >>> Cocaine HCl; Eticlopride; SCH-23390; Saline; SC; rat; 2001; controls received mp w/saline; eticlopride is a D1&D2 receptor antagonist.

2699 Alberch, J., Arenas, E., Perez-Navarro, E., Marsal, J. Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons. Naunyn-Schmiedeberg's Arch. Pharmacol 1993; 348(--):445-449. >>> Haloperidol; SCH-23390; SC; rat; controls received mp w/ saline.

2497 Srinivasan, M., Yamamoto, Y., Brodin, E., Persson, H. Chronic treatment with SCH-23390, a selective dopamine D1 receptor blocker decreases preprotachykinin-A mRNA levels in nucleus tractus solitarii of the rabbit: role in respiratory control. Mol. Brain Research 1991; 9(-3-):233-238. >>> SCH-23390; Glucose; Lactic acid; Sodium hydroxide; SC; rabbit; 2002; peptides.

2547 Howell, L.L., Byrd, L.D. Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey. J. Pharmacol. Exp. Ther 1992; 262(-3-):907-915. >>> Raclopride tartrate; SCH-23390; Saline; Alcohol; SC; monkey; 2002; controls received mp w/ saline.

2177 Burger, L.Y., Martin-Iverson, M.T. Day/night differences in D1 but not D2 DA receptor protection from EEDQ denaturation in rats treated with continuous cocaine. Synapse 1993; 13(--):20-29. >>> SCH-23390; Cocaine HCl; Raclopride; Water; SC; rat; 2ML2; no comment posted.

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24. Spiperone

1288 Shippenberg, T.S., Herz, A. Motivational effects of opioids; influence of D-1 versus D-2 receptors antagonists. Eur. J. Pharmacol 1988; 151(--):233-242. >>> Spiperone; SCH-23390; DMSO; Water; SC; rat; 2001; 2ML1; functionality of mp verified after delivery; dopamine antagonist.

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25. Other

Q2493 Ise,Y., Mori,T., Katayama,S., Nagase,H., Suzuki,T. Rewarding Effects of Ethanol Combined with Low Doses of Morphine through Dopamine D1 Receptors. JOURNAL OF NIPPON MEDICAL SCHOOL 2013; 80(-1-):34-41. >>> SCH23390; DMSO; water; SC; Rat; 2001; ; Animal info (Sprague Dawley, male, 190-230 g); 30% DMSO used.

Q2086 Leblois,A., Perkel,D.J. Striatal dopamine modulates song spectral but not temporal features through D1 receptors. European Journal of Neuroscience 2012; 35(-11-):1771-1781. >>> SCH23390; CSF/CNS (area X); Bird (zebra finch); 1002; 7-10 days; Controls received mp w/ saline; animal info (adult, male, 90 days old); single pump with Y connector; bilateral infusion using multiple cannulae; pump externalized via backpack; 0.65-mL plastic microcentrifuge tube filled with 250 ul sterile saline was used as backpack.

Q1584 Hood,S., Cassidy,P., Cossette,M.P., Weigl,Y., Verwey,M., Robinson,B., Stewart,J., Amir,S. Endogenous Dopamine Regulates the Rhythm of Expression of the Clock Protein PER2 in the Rat Dorsal Striatum via Daily Activation of D(2) Dopamine Receptors. Journal of Neuroscience 2010; 30(-42-):14046-14058. >>> SCH23390; raclopride; quinpirole; SKF 81297; Water, distilled; SC; Rat; 2ML2; 5, 10 days; Controls received sham surgery; animal info (Wistar, male, 180-210 g); SCH23390 is a D1DA receptor antagonist; raclopride is a D2Da receptor antagonist; wound clips used.

Q0202 Yao,B., Harris,R.C., Zhang,M.Z. Intrarenal Dopamine Attenuates Deoxycorticosterone Acetate/High Salt-Induced Blood Pressure Elevation in Part Through Activation of a Medullary Cyclooxygenase 2 Pathway. Hypertension 2009; 54(-5-):1077-1083. >>> SCH-23390; SC; Mice; 2004; ; Animal info (wt, COMT -/-); SCH-23390 is a D1-like receptor agonist.

Q0098 Leblois,A., Wendel,B.J., Perkel,D.J. Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors. Journal of Neuroscience 2010; 30(-16-):5730-5743. >>> Dopamine; SCH23390; Saline; CSF/CNS (area X); Bird (zebra finch); 1002; ; Controls received mp w/ vehicle; good methods (pg 5731); ALZET brain infusion kit used; animal info (adult, male); Y-connector used; pump externalized with a backpack; pump placed inside microcentrifuge tube; cannula placement verified by histological examination.

P8591 Shippenberg,T.S., Herz,A. Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of mu-and kappa-opioid agonists. Brain Res 1987; 436(-1-):169-172. >>> SCH 23390; Water; DMSO; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 140-160 grams); D1 dopamine receptor antagonist, 30% DMSO used.

P5474 Byrnes,E.M., Rigero,B.A., Bridges,R.S. Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats. Pharmacology Biochemistry and Behavior 2002; 73(-4-):869-875. >>> SCH-23390; DMSO; water, sterile; SC; Rat; 2001; ; Controls received mp w/ vehicle; agent is a D1-like antagonist.

P4367 Davidoff,S.A., Chu,H.M., Benes,F.M. Acute administration of SCH23390 increases D1 receptors on nonpyramidal neurons in rat mPFC. Synapse 2000; 35(--):173-181. >>> SCH-23390; Saline, normal; SC; rat; 1003D; 48 hours; controls received mp with vehicle.

P3341 Suzuki,T., Funada,M., Narita,M., Misawa,M., Nagase,H. Morphine-induced place preference in the CXBK mouse: characteristics of u opioid receptor subtypes. Brain Research 1993; 602(--):45-52. >>> SCH-23390; DMSO; Water; SC; mice; 2001; no duration posted; controls received mp w/vehicle; pump implanted in flank.

P3313 Azaryan,A.V., Coughlin,L.J., Buzas,B., Clock,B.J., Cox,B.M. Effect of chronic cocaine treatment on m- and d-opioid receptor mRNA levels in dopaminergically innervated brain regions. J.Neurochem. 1996; 66(--):443-448. >>> Cocaine HCl; Eticlopride; SCH-23390; Saline; SC; rat; 2001; 3 days; controls received mp w/saline; eticlopride is a D1&D2 receptor antagonist.

P2611 Alberch,J., Arenas,E., Perez-Navarro,E., Marsal,J. Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons. Naunyn-Schmiedeberg's Arch.Pharmacol. 1993; 348(--):445-449. >>> Haloperidol; SCH-23390; SC; rat; 14 days; controls received mp w/ saline.

P2489 Glenthoj,B., Bolwig,T.G., Hemmingsen,R. Effects of chronic discontinuous and continuous treatment of rats with a dopamine D receptor antagonist (NNC-756). Eur.J.Pharmacol. 1993; 242(--):283-291. >>> NNC-756; Acetic acid; Water; SC; rat; 2002; 15 weeks; comparison of Q week injections vs. mp; long-term study, pumps replaced every 2 weeks; dopamine receptor antagonist.

P2436 Srinivasan,M., Yamamoto,Y., Brodin,E., Persson,H. Chronic treatment with SCH-23390, a selective dopamine D1 receptor blocker decreases preprotachykinin-A mRNA levels in nucleus tractus solitarii of the rabbit: role in respiratory control. Mol.Brain Research 1991; 9(-3-):233-238. >>> SCH-23390; Glucose; Lactic acid; Sodium hydroxide; SC; rabbit; 2002; 14 days; peptides.

P2318 Howell,L.L., Byrd,L.D. Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey. J.Pharmacol.Exp.Ther. 1992; 262(-3-):907-915. >>> Raclopride tartrate; SCH-23390; Saline; Alcohol; SC; monkey; 2002; 14 days; controls received mp w/ saline.

P2185 Burger,L.Y., Martin-Iverson,M.T. Day/night differences in D1 but not D2 DA receptor protection from EEDQ denaturation in rats treated with continuous cocaine. Synapse 1993; 13(--):20-29. >>> SCH-23390; Cocaine HCl; Raclopride; Water; SC; rat; 2ML2; 14 days; no comment posted.

P1288 Shippenberg,T.S., Herz,A. Motivational effects of opioids; influence of D-1 versus D-2 receptors antagonists. Eur.J.Pharmacol. 1988; 151(--):233-242. >>> Spiperone; SCH-23390; DMSO; Water; SC; rat; 2001; 2ML1; 7 days; functionality of mp verified after delivery; dopamine antagonist.

P1233 Martin-Iverson,M.T., Iverson,S.D., Stahl,S.M. Long-term motor stimulant effects of (+) -4-propyl-9-hydroxynaphthoxazine (PHNO), a dopamine D-2 receptor agonist: interactions with a dopamine D-1 receptor antagonist and agonist. Eur.J.Pharmacol. 1988; 149(--):25-31. >>> Hydroxynaphthoxacine, 4-propyl-9-; SCH-23390; Water; SC; rat; 2002; 11 days; controls received mp w/water; multiple pumps per animal (2); separate and simultaneous infusion of agents; PHNO is a dopamine antagonist.

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“However, the s.c. mini-osmotic pump delivery of recombinant leptin raised circulating leptin into the physiological range (Table 2). These data confirmed the effectiveness of the s.c. infusion of leptin at 0.1 mg/day in restoring serum leptin levels.” Zhang et al. Journal of Endocrinology 2002; 174:455-461.