ALZET® Osmotic Pump References: Extended Duration Studies Using Sequentially Implanted Pumps

16276 Yahr, P. Two aromatase inhibitors inhibit the ability of a third to promote mating in male rats. Horm Behav 2015; 75(--):41-4. >>> Fadrozole; saline; SC; rat; 2002; Controls received mp w/ vehicle, sham operation; animal info (Long–Evans male, Sprague-Dawley-derived female rats); pumps replaced every 2 weeks; “They performed properly, exposing males to 0.25 mg/kg/day fadrozole” pg 42; enzyme inhibitor (aromatase); enzyme inhibitor (aromatase);.

16269 Vendrov, A. E., Vendrov, K. C., Smith, A., Yuan, J., Sumida, A., Robidoux, J., Runge, M. S., Madamanchi, N. R. NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease. Antioxid Redox Signal 2015; 23(-18-):1389-409. >>> MitoTEMPO; SC; mice; 1004; animal info (13mo Apoe-/ - mice); functionality of mp verified by ECG; pumps replaced every 4 weeks; cardiovascular; antihypertensive; isoflurane/O2 anesthesia; Dose (1500 ug/kg/d);.

16206 Maeda, S., Matsui, T., Ojima, A., Suematsu, M., Kaseda, K., Higashimoto, Y., Yamakawa, R., Yamagishi, S. DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy. Ophthalmic Res 2015; 54(-4-):175-80. >>> AGE-aptamer; BSA; IP; rat; 1004; Controls received mp w/ control aptamer; animal info (Six-week-old male Wistar rats); functionality of mp verified by urine tests; pumps replaced every 4 weeks; antisense (AGE-aptamer versus control aptamer); diabetes; AGE-aptamer aka Advanced Glycation End Products Aptamer; Dose (6 ng/body weight/day);.

16190 Iwasaki, Y., Kazama, J. J., Yamato, H., Matsugaki, A., Nakano, T., Fukagawa, M. Altered material properties are responsible for bone fragility in rats with chronic kidney injury. Bone 2015; 81(--):247-54. >>> Parathyroid hormone, rat; SC; rat; 2002; Controls received sham operation; animal info: 12-week-old male Sprague-Dawley; functionality of mp verified by urine samples; pumps replaced every 2 weeks; pumps replaced every 2 weeks; long-term study; Dose: 0.1Ǩg/kg/h.

16171 Scarpace, P. J., Matheny, M., Strehler, K. Y., Toklu, H. Z., Kirichenko, N., Carter, C. S., Morgan, D., Tumer, N. Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats. J Gerontol A Biol Sci Med Sci 2016; 71(-7-):891-9. >>> Rapamycin; DMSO; PEG 400; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, F344 x Brown Norway, 24 months old); pumps replaced after 14 days; ALZET brain infusion kit used; 10% DMSO used; 90% PEG 400 used; post op. care (rats kept warm until recovered); used aCSF filled pump for 14 days, then replaced with rapamycin or vehicle for 28 day infusion; obesity; Dose (30 ug/day); Brain coordinates (1.3 mm posterior to bregma, 1.9 mm lateral to the midsaggital suture and to a depth of 3.5mm);.

16127 Ghanbari, A., Esmaeilpour, T., Bahmanpour, S., Golmohammadi, M. G., Sharififar, S., Azari, H. Depletion of neural stem cells from the subventricular zone of adult mouse brain using cytosine b-Arabinofuranoside. Brain Behav 2015; 5(-11-):e00404. >>> Ara-C; Saline; CSF/CNS (right lateral ventricle); Mice; 1007D; Controls received sham operation and mp w/ vehicle; animal info: Five-week-old male C57-BL6 mice; pumps replaced once after 7 days; ALZET brain infusion kit 3 used; good methods (pg 2); post op. care (0.5 mg/kg buprenorphine every 12 h for 48 hours); cyanoacrylate adhesive (Loctite 454); delayed delivery (6-12 hours); Dose: 2% Ara-C in Saline; Brain coordinates; Paxinos mouse brain Atlas: Anterior-Posterior (AP): _0. 2, Medial-Lateral (ML): +0. 9 from the bregma point and Dorsal-Ventral: +2.7 from the top of skull.

16092 Appleton, C. T., Usmani, S. E., Pest, M. A., Pitelka, V., Mort, J. S., Beier, F. Reduction in disease progression by inhibition of transforming growth factor alpha-CCL2 signaling in experimental posttraumatic osteoarthritis. Arthritis Rheumatol 2015; 67(-10-):2691-701. >>> AG1478; RS504393; DMSO; water, deionized; SC; rat; 2ML4; Controls received mp w/ vehicle; functionality of mp verified by plasma levels and knee articular cartilage; pumps replaced every 4 weeks; %50 of DMSO; long-term study; enzyme inhibitor (EGFR and CCR2 inhibitors); EGFR inhibitor AG1478, CCR2 inhibitor RS504393; Dose: (AG1478) 21 nmoles/kg/hour; (RS504393) 200 nmoles/kg/hour.

16084 Zhao, L., Zhuang, J., Xu, F. Bronchopulmonary C-fibers'IL1RI contributes to the prolonged apneic response to intra-atrial injection of capsaicin by prenatal nicotinic exposure in rat pups. Toxicol Appl Pharmacol 2016; 303(--):58-64. >>> Nicotine; methyllycaconitine; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g); pumps replaced every 28 days; Multiple pumps per animal (2); long-term study; teratology; MLA is an a7nAChR antagonist; methyllycaconitine aka MLA; Dose (nicotine 6 mg/kg/day; MLA 3 mg/kg/day);.

16074 Yang, J., Chen, Y. N., Xu, Z. X., Mou, Y., Zheng, L. R. Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats. Cell Physiol Biochem 2016; 39(-1-):229-41. >>> Alendronate; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, spontaneously hypertensive rat or Wistam-Kyoto, 6 weeks old); pumps replaced every 4 weeks; long-term study; cardiovascular; enzyme inhibitor (farnesyl pyrophosphate synthase); bp measured using tail cuff; Dose (100 ug/kg/day);.

16052 Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L., Ottinger, M. A. A comparative evaluation of treatments with 17beta-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease. Horm Behav 2016; 83(--):39-44. >>> DHED; estradiol, 17B-; Propylene glycol; SC; Mice (transgenic); 2004; Controls received mp w/ vehicle; animal info (female, APPswe/PS1dE9, 6 months old); functionality of mp verified by plasma levels (see figure S1 - E2 only; no assay for DHED); pumps replaced every 4 weeks; neurodegenerative (Alzheimer’s); replacement therapy (estradiol infusion); DHED aka 10Ǟ,17Ǟ-dihydroxyestra-1,4-dien-3-one; Dose (2 ug/day); Industry authored (AgyPharma LLC);.

16049 Uchi, Y., Takeuchi, H., Matsuda, S., Saikawa, Y., Kawakubo, H., Wada, N., Takahashi, T., Nakamura, R., Fukuda, K., Omori, T., Kitagawa, Y. CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis. BMC Cancer 2016; 16(--):514. >>> AMD3100; SC; Mice (nude); 2001; Controls received mp w/ 0.1% BSA; animal info (female, BALB/c nude, 6 weeks old); pumps replaced every week; cancer (Esophageal squamous cell carcinoma TE4); xenograft model;.

16045 Toklu, H. Z., Bruce, E. B., Sakarya, Y., Carter, C. S., Morgan, D., Matheny, M. K., Kirichenko, N., Scarpace, P. J., Tumer, N. Anorexic response to rapamycin does not appear to involve a central mechanism. Clin Exp Pharmacol Physiol 2016; 43(-9-):802-7. >>> Rapamycin; DMSO; PEG 400; CSF/CNS (third ventricle); Rat; Controls received mp w/ vehicle; animal info (male, F344 Brown Norway, 23-25 months old); 10% DMSO used; used PE-50 tubing; pumps initially filled with aCSF - after one week recovery, pumps replaced with rapamycin or vehicle pump; Dose (30 ug/day); Brain coordinates (1.1 mm posterior to Bregma and 1.6 mm ventral from the skull surface on the midline (medial s- sure), with the nose bar set at 4 mm below the ear bars (below zero)) pg 805;.

16041 Teng, B. L., Nikolova, V. D., Riddick, N. V., Agster, K. L., Crowley, J. J., Baker, L. K., Koller, B. H., Pedersen, C. A., Jarstfer, M. B., Moy, S. S. Reversal of social deficits by subchronic oxytocin in two autism mouse models. Neuropharmacology 2016; 105(--):61-71. >>> Risperidone; SC; Mice; 1002; 1007D; Controls received mp w/ vehicle; animal info (C58/J); pumps replaced every 14 days; behavioral testing (chamber choice task; acoustic startle test; marble burying assay);“This pump replacement allowed dosage to be adjusted for increased body weight during the chronic risperidone treatment.“ pg 62-63; Dose (2 mg/kg/day); used clozapine slow-release pellets because of drug solubility (pg.62);.

16027 Hussmann, G. P., DeDominicis, K. E., Turner, J. R., Yasuda, R. P., Klehm, J., Forcelli, P. A., Xiao, Y., Richardson, J. R., Sahibzada, N., Wolfe, B. B., Lindstrom, J., Blendy, J. A., Kellar, K. J. Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. J Neurochem 2014; 129(-4-):721-31. >>> nicotine; sazetidine-A; varenicline; saline; SC; rat, mice; Controls received mp w/ saline vehicle; animal info (male adult Sprague-dawley rats, 8 weeks, 240 g; male 129SvJ;C57BL/6J F1 hybrid mice, 6 weeks, 25-30 g ); functionality of mp verified by protein binding in rat cortex ; pumps replaced after 2 weeks; 1 additional week of infusion for mice, 4 additional weeks of infusion for rats; post op. care (buprenorphine or ketoprofen injected for analgesia); behavioral testing (memory retention and attention in rats); Saz-A aka sazetidine-A; Rats Dose: 6 mg/kg/day nicotine, 4.7 mg/kg/day saz-A, 1.2 mg/kg/day vareniclineMice Dose: 18 mg/kg/day nicotine, 1.8 mg/kg/day saz-A, 1.8 mg/kg/day varenicline.

16000 Ko, A. R., Kang, T. C. Blockade of endothelin B receptor improves the efficacy of levetiracetam in chronic epileptic rats. Seizure 2015; 31(--):133-40. >>> Levetiracetam; SB202190; BQ788; SC; Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 7 days); pumps replaced between trials;.

15999 Hongu, T., Funakoshi, Y., Fukuhara, S., Suzuki, T., Sakimoto, S., Takakura, N., Ema, M., Takahashi, S., Itoh, S., Kato, M., Hasegawa, H., Mochizuki, N., Kanaho, Y. Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial beta1 integrin recycling. Nat Commun 2015; 6(--):7925. >>> SecinH3; DMSO; glycerol; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (male, Arf6 flox/flox, 8 weeks old); pumps replaced every 4 days; 50% DMSO used; 50% glycerol; cancer (B16 melanoma or LLC); xenograft model;.

15997 Uli S. Herrmann,, Anne K. Schütz,, Hamid Shirani,, Danzhi Huang,, Dino Saban, Mario Nuvolone,, Bei Li,, Boris Ballmer,, Andreas K. O.Åslund,, Jeffrey J. Mason,, Elisabeth Rushing,, Herbert Budka,, Sofie Nyström,, Per Hammarström,, Anja Böckmann,, Amedeo Caflisch,, Beat H. Meier,, K. Peter R. Nilsson,, Simone Hornemann,, Adriano Aguzzi  Science Translational Medicine 2015; 7(-299-):1-18. >>> LIN1001l; LIN5001; LIN5002; LIN7002; PBS; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (WT CD1 or PrP-overexpressing mice); pumps replaced every 42 days; post op. care (Finadyne 2.5 mg/kg BID SC; Temgesic SC injection 0.1 mg/kg; Borgal 2ml 24% in drinking water); post op. care (Finadyne 2.5 mg/kg BID SC; Temgesic SC injection 0.1 mg/kg; Borgal 2ml 24% in drinking water); long-term study; Dose (3.3 mg/kg/week); brain coordinates;.

15980 Iorgulescu, J. B., Patel, S. P., Louro, J., Andrade, C. M., Sanchez, A. R., Pearse, D. D. Acute Putrescine Supplementation with Schwann Cell Implantation Improves Sensory and Serotonergic Axon Growth and Functional Recovery in Spinal Cord Injured Rats. Neural Plast 2015; 2015(--):186385. >>> Putrescine; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (female, Fischer, adult, 180-200g); pumps replaced every week; spinal cord injury; behavioral testing (locomotor activity);.

15970 Lataro, R. M., Silva, C. A., Tefe-Silva, C., Prado, C. M., Salgado, H. C. Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats. Am J Hypertens 2015; 28(-10-):1201-8. >>> Pyridostigmine bromide; donepezil; SC; Rat; 2004; animal info (male, Wistar-Kyoto or SHR); pumps replaced every 4 weeks; long-term study; cardiovascular; bp measured using tail cuff; Dose (Pyridostigmine bromide 1.5 mg/kg/day; donepezil 1.4 mg/kg/day);.

15918 Murakami, S., Miyazaki, I., Miyoshi, K., Asanuma, M. Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson's Disease in Mice. Neurochem Res 2015; 40(-6-):1165-78. >>> Rotenone; DMSO; PEG; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 20-25g, 9 weeks old); pumps replaced every 3 weeks; 50% DMSO used; 50% PEG used; neurodegenerative (Parkinson's disease); behavioral testing (locomotor activity); Dose (50 mg/kg/day);.

15904 Laszlo Prokai,, Vien Nguyen,, Szabolcs Szarka, Puja Garg,, Gauri Sabnis, Heather A. Bimonte-Nelson,, Katie J. McLaughlin,, Joshua S. Talboom,, Cheryl D. Conrad,, Paul J. Shughrue,, Todd D. Gould,, Angela Brodie,, Istvan Merchenthaler,, Peter Koulen,, Katalin Prokai-Tatrai  Science Translational Medicine 2015; 7(-297-):1-11. >>> DHED; estradiol, 17b-; PEG; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Fischer 344, middle aged, OVX); pumps replaced every 14 days; behavioral testing (plus maze); Dose (4 ug/day);.

15893 Vieira, F. G., Ping, Q., Moreno, A. J., Kidd, J. D., Thompson, K., Jiang, B., Lincecum, J. M., Wang, M. Z., De Zutter, G. S., Tassinari, V. R., Levine, B., Hatzipetros, T., Gill, A., Perrin, S. Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. PLoS One 2015; 10(-8-):e0135570. >>> Guanabenz acetate; Ethanol; water; propylene glycol; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (SOD1-G93A); pumps replaced every 28 days; dose-response (pg 4); neurodegenerative (amyotrophic lateral sclerosis); post op. care (antibiotic ointment; buprenorphine 0.1 mg/kg); long-term study; used lot#10284-12; Dose (0.45, 1.5, or 4.5 mg/kg/day);.

15879 Sun, M., Tian, X., Liu, Y., Zhu, N., Li, Y., Yang, G., Peng, C., Yan, C., Han, Y. Cellular repressor of E1A-stimulated genes inhibits inflammation to decrease atherosclerosis in ApoE(-/-) mice. J Mol Cell Cardiol 2015; 86(--):32-41. >>> CREG, recombinant human; PBS; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, ApoE -/-, 10 weeks old, 20-25g); pumps replaced every 2 weeks; cardiovascular; cardiovascular; Dose (30 ug/kg/day);.

15871 Ruban, A., Malina, K. C., Cooper, I., Graubardt, N., Babakin, L., Jona, G., Teichberg, V. I. Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment. Neurodegener Dis 2015; 15(-4-):233-42. >>> Kanic acid; cyclothiazide; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; animal info (male, Wistar, 8-9 weeks old, 240-250g); pumps replaced every week; neurodegenerative (ALS amyotrophic lateral sclerosis); behavioral testing (rotarod testing); pumps primed in 37C sterile saline overnight; catheter placement verified by visual examination;.

15861 Zhao, L., Zhuang, J., Zang, N., Lin, Y., Lee, L. Y., Xu, F. Prenatal nicotinic exposure upregulates pulmonary C-fiber NK1R expression to prolong pulmonary C-fiber-mediated apneic response. Toxicol Appl Pharmacol 2016; 290(--):107-15. >>> Nicotine; mecamylamine; methyllycaconitine; SC; Rat (pregnant); 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-300g); pumps replaced on GD7; Multiple pumps per animal (2); no stress (see pg. 110-111); teratology; Dose (Nicotine 6 mg/kg/day; mecamylamine 0.03 mg/kg/day; methyllycaconitine 3 mg/kg/day);.

15837 Renjun Wang, PhD; Qian Huang, MD; Rui Zhou, BSc; Zengxiang Dong, PhD;, Yunfeng Qi, PhD; Hua Li, MS; Xiaowei Wei, MS; Hui Wu, MS; Huiping Wang, PhD;, Christopher S. Wilcox, MD, PhD; Michael Hultström, MD, PhD; Xiaofu Zhou, PhD;, En Yin Lai, MD, PhD  Circ Heart Fail. 2016; 9(--):1-10. >>> AntagomiR-7b; RNA, small interfering GABBR1; angiotensin II; CSF/CNS (paraventricular nucleus); Rat; 1004; 1002; animal info (male, Wistar, 180-200g); pumps replaced after 4 weeks; bilateral cannula used; tissue perfusion (paraventricular nucleus); cardiovascular; peptides; bilateral infusion; Dose (AntagomiR-7b or Ad-siGABBR1 40 ng/h; antiotensin II 1 ng/kg/min);.

15806 C C Paccola and S M Miraglia  REPRODUCTION 2016; 151(--):117-133. >>> Nicotine hydrogen tartrate salt; Water, bacteriostatic; SC; Rat (pregnant; lactating); 2ML4; Controls received mp w/ vehicle; animal info (GD1); pumps replaced after birth; no stress (see pg. 123); cyanoacrylate adhesive;“There were no cases of stillbirth, birth defects, or other signs of toxicity that could be attributed to nicotine. Behavioral changes in the rat dams that could be attributed to the stress caused by the osmotic minipump implant were also not evidenced. Body weights were obtained at every chosen age of killing and no differences were found when nicotine and control groups were compared, at any ageequivalent subgroup. The” pg 123; Dose (2 mg/kg/day);.

15796 Dusan Matusica, Fabienne Alfonsi, Bradley J. Turner, Tim J. Butler, Stephanie R. Shepheard, Mary-Louise Rogers, Sune Skeldal, Clare K. Underwood, Marie Mangelsdorf, Elizabeth J. Coulson  Journal of Cell Science 2016; 129(--):517-530. >>> Peptide, c29; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (SOD G93A, 9 weeks old); pumps replaced every month until death; neurodegenerative (amyotrophic lateral sclerosis); neurodegenerative (amyotrophic lateral sclerosis); long-term study; peptides; Dose (5 mg/kg/day);.

15782 Andriana G Kotini, Elisa de Stanchina, Maria Themeli, Michel Sadelain, Eirini P Papapetrou  MOLECULAR THERAPY 2016; 5(--):. >>> Ganciclovir; PBS; SC; Mice (NSG); 1007D; animal info (female, NSG, 8 weeks old); pumps replaced every week; cancer (teratoma); Dose (5 mg/kg/day);.

15780 Brigitte Koenig, Daniel Pape, Owen Chao, Jordana Bauer, Barbara Grimpe  Experimental Neurology 2016; 276(--):51-58. >>> DNAXT-1as; CSF/CNS (intrathecal); Rat; 1007D; Controls received mp w/ control enzyme or PBS; animal info (female, Wistar, 200-250g); pumps replaced every week; pumps replaced every week; spinal cord injury; post op. care (Baytril; manual bladder emptying; Rimadyl); behavioral testing (horizontal ladder task); used self-made intrathecal catheter from 32-gauge polyurethane; enzyme inhibitor (DNA enzyme of mRNA of xylosyltransferase-1);.

15778 Ai Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Takuji Kawamura, Noriyuki Kashiyama, Emiko Ito, Tadashi Watabe, Shigeo Masuda, Koichi Toda, Jun Hatazawa, Eiichi Morii, Yoshiki Sawa  SCIENTIFIC REPORTS 2016; 6(--):1-13. >>> Tacrolimus; SC; Mice; 1002; cancer (teratocarcinoma); immunology; animal info (BALB/c); functionality of mp verified by plasma levels; pumps replaced after 14 days; BLI; Dose (1.5 mg/kg);.

15768 Erivan Clementino Gualberto Jr., Letícia Helena Theodoro, Mariellén Longo, Vivian Cristina Noronha Novaes, Maria JoséHitomi Nagata, Edilson Ervolino, Valdir Gouveia Garcia  Lasers med sci 2016; 31(--):83-94. >>> Nicotine; Saline; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (female, Wistar, 3 months old, 266+/-6.5g); pumps replaced after 40 days; Dose (6 mg/kg/day);.

15758 Daniel G. Donner,, Grace E. Elliott,, Belinda R. Beck,, Andrew C. Bulmer,, Alfred K. Lam,, John P. Headrick,, and Eugene F. Du Toit  Endocrinology 2016; 157(-1-):368-381. >>> Testosterone; trenbolone; Cyclodextrin, 2b-hydroxypropyl; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 12 weeks old, 300g); functionality of mp verified by plasma; pumps replaced every 4 weeks; 45% cyclodextrin used; ischemia (cardiac); post op. care (buprenorphine 10 ug/kg/day IM; enrofloxacin 5 mg/kg ip for 3 days); long-term study; Dose (2 mg/kg/day);.

15739 Sandra L. Burke,, Elena V. Lukoshkova, and Geoffrey A. Head  Experimental Physiology 2016; 101(-1-):50-66. >>> Angiotensin II; SC; Rabbit; 2ML4; Controls received dummy pump; animal info (male, New Zealand White, 2.4-2.7 kg); pumps replaced every 4 weeks; Dose (20 ng/kg/min for 8 weeks or 50 ng/kg/min for 4 weeks);.

15725 Jeffrey A. Blair,, Russell Palm,, Jaewon Chang,, Henry McGee,, Xiongwei Zhu,, Xinglong Wang,, Gemma Casadesus  Horm. Behav 2016; 78(--):60-66. >>> Estradiol, 17b; leuprolide acetate; Saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J, 9 months old, OVX); pumps replaced every month; behavioral testing (morris water maze); replacement therapy (estradiol infusion); Dose (E2 1.1 ng/day; leuprolide 3.6 ug/day);.

15724 Sara K.S. Bengtsson,, Maja Johansson,, Torbjörn Bäckström  Horm. Behav 2016; (-78-):160-167. >>> Allopregnanolone; Captisol; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J); pumps replaced every month; 60% Captisol used; post op. care (Carprofen); behavioral testing (Morris water maze); long-term study; Industry authored (Umecrine Cognition AB);.

15235 Shinohara, K., Hata, T. Post-acquisition hippocampal NMDA receptor blockade sustains retention of spatial reference memory in Morris water maze. BEHAVIOURAL BRAIN RESEARCH 2014; 259(-;-):261-267. >>> AP5, D-; CSF, artificial; CSF/CNS (hippocampus); Rat; 1007D; Animal info (male, albino Wistar); pumps replaced every 7 days; Plastics One bilateral cannula used; Multiple pumps per animal (2); behavioral testing (morris water maze, probe test); tissue perfusion (hippocampus); Cannula placement verified via histological analysis; pumps primed for 24 hours in 37C saline; bilateral infusion;.

15208 Cunningham, C.S., Moerke, M.J., McMahon, L.R., McMahon, L.R. The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys1734. BEHAVIOURAL PHARMACOLOGY 2014; 25(--):296-305. >>> Nicotine; Saline; SC; Monkey (Rhesus); 2ML4; Controls received mp w/ vehicle; animal info (Macaca mulatta, rhesus monkey, adult); pumps replaced every 28 days; behavioral testing (stimulus-shock termination);.

15172 Zhang, X., Thatcher, S., Wu, C.Q., Daugherty, A., Cassis, L.A., Cassis, L.A. Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms. JOURNAL OF VASCULAR SURGERY 2015; 61(--):767-776. >>> Angiotensin II; SC; Mice; 1004; Animal info (male, ApoE -/-, 2 months old, orchiectomy); pumps replaced every month; long-term study; cardiovascular; peptides;.

15157 Yonezawa, T., Chen, K.H., Ghosh, M.K., Rivera, L., Dill, R., Ma, L.S., Villa, P.A., Kawaminami, M., Walker, A.M., Walker, A.M. Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer. CANCER LETTERS 2015; 366(--):84-92. >>> Prolactin, recombinant human; oligomer, splice-modulating; SC; Mice (NOD/SCID); Controls received mp w/ vehicle; animal info (female, BALB/cJ or NOD SCID, 8-9 weeks old); functionality of mp verified by plasma levels; pumps replaced every 28 days; cancer (breast); dose-response (pg 87);.

15155 Yan, T.T., Xiong, W.W., Huang, F.R., Zheng, F., Ying, H.F., Chen, J.F., Qu, J., Zhou, X.T., Zhou, X.T. Daily Injection But Not Continuous Infusion of Apomorphine Inhibits Form-Deprivation Myopia in Mice. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2015; 56(--):2475-2485. >>> Apomorphine; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57Bl6, 4 weeks old); functionality of mp verified by residual volume; pumps replaced every 2 weeks; comparison of injection vs mp;.

15148 Yamazaki, H., Takagi, S., Hosoya, K., Okumura, M., Takagi, S. Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. RESEARCH IN VETERINARY SCIENCE 2015; 99(--):137-144. >>> YM155; lomustine; Saline; SC; IP; Mice (nude); 1003D; 1007D; Controls received mp w/ vehicle; animal info (female, nude, 4 weeks old); pumps replaced every week; cancer (canine histiocytic sarcoma); 3 days of continuous infusion per week for 3 weeks; lomustine aka CCNU;.

15144 Wong, H.K.A., El Fatimy, R., Onodera, C., Wei, Z.Y., Yi, M., Mohan, A., Gowrisankaran, S., Karmali, P., Marcussont, E., Wakimoto, H., Stephens, R., Uhlmann, E.J., Song, J.S., Tannous, B., Krichevsky, A.M., Krichevsky, A.M. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma. MOLECULAR THERAPY 2015; 23(--):1234-1247. >>> RNA, micro antisense inhibitors 2'-O-MOE-PO; CSF/CNS (striatum); Mice (nude); 2004; Animal info (nude, 8 weeks old); pumps replaced every 30 days; ALZET brain infusion kit 3 used;"To ensure efficient and continuous local delivery of either miR-31 or miR-148a inhibitors to the intracranial tumors, and avoid repeated neurosurgeries, we used osmotic pumps"pg 1236; picture of implanted pump pg 1238;.

15254 Wheelan, N., Webster, S.P., Kenyon, C.J., Caughey, S., Walker, B.R., Holmes, M.C., Seckl, J.R., Yau, J.L.W., Yau, J.L.W. Short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice. NEUROPHARMACOLOGY 2015; 91(--):71-76. >>> UE2316; DMSO; PEG; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6J, 24 months old); pumps replaced every 21 days with opposite treatment (drug replaced with vehicle, etc.); 50% DMSO used; 50% PEG used; behavioral testing (spatial memory y-maze; contextual fear conditioning); long-term study;.

15131 Wang, M.Y., Yan, H., Shi, Z.Q., Evans, M.R., Yu, X.X., Lee, Y., Chen, S., Williams, A., Philippe, J., Roth, M.G., Unger, R.H., Roth, M.G. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):2503-2508. >>> Leptin, recombinant; pramlintide acetate; liraglutide; exenatide; SC; Mice (NOD); 2001; Controls received mp w/ PBS; animal info (female, NOD/ShiLtJ, 8 weeks old); pumps replaced every 7 days; long-term study; diabetes;.

15112 Thomas, N.P., Li, P.C., Fleming, B.C., Chen, Q., Wei, X.C., Pan, X.H., Li, G., Wei, L., Wei, L. Attenuation of cartilage pathogenesis in post-traumatic osteoarthritis (PTOA) in mice by blocking the stromal derived factor 1 receptor (CXCR4) with the specific inhibitor, AMD3100. JOURNAL OF ORTHOPAEDIC RESEARCH 2015; 33(--):1071-1078. >>> AMD3100; SC; Mice; 1004; Controls received mp w/ PBS or empty pumps; animal info (male, C57BL6J, 2 months old); pumps replaced every 4 weeks; long-term study;.

15100 Tan, C.Y.R., Weier, Q., Zhang, Y., Cox, A.J., Kelly, D.J., Langham, R.G., Langham, R.G. Thioredoxin-Interacting Protein: A Potential Therapeutic Target for Treatment of Progressive Fibrosis in Diabetic Nephropathy. NEPHRON 2015; 129(--):109-127. >>> Thioredoxin-interacting protein DNAzyme; SC; Rat; 2006; Controls received mp w/ scrambled TXNIP DNAzyme; animal info (female, heterozygous (mRen-2)27, 6 weeks old); pumps replaced every 6 weeks; cardiovascular; diabetes; Thioredoxin-interacting protein aka TXNIP;.

15083 Shultz, S.R., Wright, D.K., Zheng, P., Stuchbery, R., Liu, S.J., Sashindranath, M., Medcalf, R.L., Johnston, L.A., Hovens, C.M., Jones, N.C., O'Brien, T.J., Shultz, S.R. Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury. BRAIN 2015; 138(--):1297-1313. >>> Sodium selenate; Saline; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (Long Evans hooded, 12 weeks old, 250-300g); pumps replaced every 6 weeks; long-term study; traumatic brain injury;.

15062 Plante, E., Menaouar, A., Danalache, B.A., Yip, D., Broderick, T.L., Chiasson, J.L., Jankowski, M., Gutkowska, J., Gutkowska, J. Oxytocin Treatment Prevents the Cardiomyopathy Observed in Obese Diabetic Male db/db Mice. ENDOCRINOLOGY 2015; 156(--):1416-1428. >>> Oxytocin; NaCl; BSA; sodium citrate; SC; Mice; 2006; Controls received mp w/ vehicle; animal info (C57BL/KsJ-leptdb-leptdb); functionality of mp verified by plasma levels; pumps replaced every 6 weeks; long-term study; diabetes;“After 6 weeks, the osmotic pumps were replaced to adjust the OT concentration for body weight gain.” pg 1417;.

15019 Dixon, K.J., Theus, M.H., Nelersa, C.M., Mier, J., Travieso, L.G., Yu, T.S., Kernie, S.G., Liebl, D.J., Liebl, D.J. Endogenous Neural Stem/Progenitor Cells Stabilize the Cortical Microenvironment after Traumatic Brain Injury. JOURNAL OF NEUROTRAUMA 2015; 32(--):753-764. >>> Ganciclovir sodium; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (CD1 nestin TK, adult); pumps replaced every 2 weeks; behavioral testing (motor function/rotarod test); traumatic brain injury;.

14997 Kogo, R., How, C., Chaudary, N., Bruce, J., Shi, W., Hill, R.P., Zahedi, P., Yip, K.W., Liu, F.F., Liu, F.F. The microRNA-218similar toSurvivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. ONCOTARGET 2015; 6(--):1090-1100. >>> YM155; SC; Mice (SCID); 1003D; Controls received mp w/ saline; animal info (female, SCID, 6-8 weeks old); pumps replaced every week - YM155 administered 3 days per week for 2 weeks; cancer (cervical); YM155 is a small molecule survivin inhibitor;.

14968 Hopp, K., Hommerding, C.J., Wang, X.F., Ye, H., Harris, P.C., Torres, V.E., Torres, V.E. Tolvaptan plus Pasireotide Shows Enhanced Efficacy in a PKD1 Model. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):39-47. >>> Desmopressin; pasireotide; Mice; 1004; Controls received mp w/ saline; animal info (Pkd1 RC/RC, 3 weeks old); pumps replaced every 3 weeks; no stress (see pg. 44); long-term study; cardiovascular;“The minipumps were replaced every 3 weeks, and all animals survived the trial period.” pg 44; desmopressin aka dVAP;.

14967 Hopp, K., Wang, X.F., Ye, H., Irazabal, M.V., Harris, P.C., Torres, V.E., Torres, V.E. Effects of hydration in rats and mice with polycystic kidney disease. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 2015; 308(--):F261-F266. >>> Vasopressin, 1-deamino-8-D arginine; Saline; SC; Rat; mice; 1004; 2004; 2ML4; Controls received mp w/ vehicle; animal info (rat PCK, 3 weeks old; mice Pkd1 RC/RC or Pkd2 WS25/- 4 weeks old); pumps replaced every 3 weeks; cardiovascular;.

14958 Hardwick, J.C., Ryan, S.E., Powers, E.N., Southerland, E.M., Ardell, J.L., Hardwick, J.C. Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 309(--):R179-R188. >>> Captopril; losartan; CGP42112A; SC; Guinea Pig; 2ML4; Animal info (male, Hartley, 9 weeks old, 500-650g); pumps replaced every 3 weeks; cardiovascular; long-term study;.

14949 Hamilton, C.B., Pest, M.A., Pitelka, V., Ratneswaran, A., Beier, F., Chesworth, B.M., Beier, F. Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis. OSTEOARTHRITIS AND CARTILAGE 2015; 23(--):1178-1185. >>> Water, distilled; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 301-325g); pumps replaced every 4 weeks; post op. care (buprenorphine 50 ug/kg SC); behavioral testing (static weight bearing, exploratory motor behavior); long-term study;.

14929 Erdos, B., Backes, I., McCowan, M.L., Hayward, L.F., Scheuer, D.A., Erdos, B. Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H612-H622. >>> Losartan; Saline; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 7 weeks old); pumps replaced every 2 weeks; cardiovascular; bp measured using radiotelemetry; used guide infusion cannula from Plastics One;.

14923 Donner, D.G., Beck, B.R., Bulmer, A.C., Lam, A.K., Du Toita, E.F., Donner, D.G. Improvements in body composition, cardiometabolic risk factors and insulin sensitivity with trenbolone in normogonadic rats. STEROIDS 2015; 94(--):60-69. >>> Trenbolone; Cyclodextrin, 2b-hydroxypropyl; water; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 32 weeks old, 300g); pumps replaced every 28 days; long-term study; cardiovascular;.

14911 gado-Cortes, M.J., Espinosa-Oliva, A.M., Sarmiento, M., Argueelles, S., Herrera, A.J., Maurino, R., Villaran, R.F., Venero, J.L., Machado, A., de Pablos, R.M., de Pablos, R.M. Synergistic Deleterious Effect of Chronic Stress and Sodium Azide in the Mouse Hippocampus. CHEMICAL RESEARCH IN TOXICOLOGY 2015; 28(--):651-661. >>> Sodium azide; SC; Mice; 2004; Controls received mp w/ isotonic saline; animal info (male, C57Bl6, 25-30g); pumps replaced every month; neurodegenerative (Alzheimer's disease);.

14903 Czoty, P.W., Tran, P., Thomas, L.N., Martin, T.J., Grigg, A., Blough, B.E., Beveridge, T.J.R., Czoty, P.W. Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats. PSYCHOPHARMACOLOGY 2015; 232(--):2405-2414. >>> Amphetamine, D-; phenmetrazine; Saline; SC; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 300-350g); pumps replaced every 7 days; behavioral testing (cocaine self-administration, food self-administration); dependence;.

14890 Chou, C.L., Pang, C.Y., Lee, T.J.F., Fang, T.C., Fang, T.C. Beneficial Effects of Calcitriol on Hypertension, Glucose Intolerance, Impairment of Endothelium-Dependent Vascular Relaxation, and Visceral Adiposity in Fructose-Fed Hypertensive Rats. PLoS One 2015; 10(--):U2028-U2046. >>> Calcitriol; PEG; SC; Rat; 2002; Animal info (male, Wistar-Kyoto, 200-230g); functionality of mp verified by residual volume; pumps replaced every 2 weeks; post op. care (penicillin SC injection 5000 U/kg); bp measured using tail cuff;.

14840 Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Nicoletti, F., Bruno, V., Bruno, V. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 2015; 74(--):126-136. >>> LY379268; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J or SOD1G93A, 8 weeks old, 20-22g); pumps replaced every 28 days; neurodegenerative (amyotrophic lateral sclerosis); behavioral testing (rotarod testing); immunology;.

14822 leaume-Butaux, A., Nicot, S., Pietri, M., Baudry, A., Dakowski, C., Tixador, P., rdila-Osorio, H., Haeberle, A.M., Bailly, Y., Peyrin, J.M., Launay, J.M., Kellermann, O., Schneider, B., leaume-Butaux, A. Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation. PLoS Pathogens 2015; 11(--):U248-U272. >>> Y-27632; dimethylfasudil; DMSO; saline; IP; Mice; Controls received mp w/ vehicle; animal info (C57BL6J, adult); pumps replaced every 4 weeks; behavioral testing (statiic rod test); enzyme inhibitor (Rho-associated protein kinase; ROCK);.

14802 Reizel, Y., Spiro, A., Sabag, O., Skversky, Y., Hecht, M., Keshet, I., Berman, B.P., Cedar, H., Cedar, H. Gender-specific postnatal demethylation and establishment of epigenetic memory. GENES&DEVELOPMENT 2015; 29(--):923-933. >>> Testosterone; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6, 3 or 20 weeks old); pumps replaced every 28 days; replacement therapy (testosterone replacement); long-term study; pumps primed for 48 hours in 37C saline;.

14800 Razgado-Hernandez, L.F., Espadas-Alvarez, A.J., Reyna-Velazquez, P., Sierra-Sanchez, A., naya-Martinez, V., Jimenez-Estrada, I., Bannon, M.J., Martinez-Fong, D., ceves-Ruiz, J., ceves-Ruiz, J. The Transfection of BDNF to Dopamine Neurons Potentiates the Effect of Dopamine D3 Receptor Agonist Recovering the Striatal Innervation, Dendritic Spines and Motor Behavior in an Aged Rat Model of Parkinson's Disease. PLoS One 2015; 10(--):U852-U876. >>> 7-OH-DPAT; IP; Rat; 2006; Animal info (male, Wistar, 17 months old, 400-500g); pumps replaced every 1.5 months; neurodegenerative (Parkinson's disease); behavioral testing (gait analysis, rotarod performance, open field); 7-OH-DPAT aka 7-hydroxy-N,N-di-n-propy1-2-aminotetralin;.

14796 Radwan, M., Wilkinson, D.J., Hui, W., Destrument, A.P.M., Charlton, S.H., Barter, M.J., Gibson, B., Coulombe, J., Gray, D.A., Rowan, A.D., Young, D.A., Young, D.A. Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination. ANNALS OF THE RHEUMATIC DISEASES 2015; 74(--):1580-1587. >>> MG132; DMSO; PEG 300; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BOL6J or mutant-Ub transgenic, 8 weeks old); pumps replaced every 4 weeks; 50% DMSO used; 50% PEG 300; long-term study; enzyme inhibitor (proteasome, general);.

15938 Ono, D., Honma, K., Honma, S. Circadian and ultradian rhythms of clock gene expression in the suprachiasmatic nucleus of freely moving mice. Sci Rep 2015; 5(--):12310. >>> Luciferin K, D-; luciferin Na, D-; Saline; CSF, artificial; IP; CSF/CNS; Mice; 2002; animal info (2-6 months old); pumps replaced after 15 days;.

14779 Zhuang, J.G., Zhao, L., Zang, N., Xu, F.D., Xu, F.D. Prenatal nicotinic exposure augments cardiorespiratory responses to activation of bronchopulmonary C-fibers. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2015; 308(--):L922-L930. >>> Nicotine; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g); pumps replaced on 7th day of gestation; teratology;.

14491 Xu, S.Q., Jiang, Y.W., Wang, H., Wang, Z., Liu, H.L., Peng, L., Fang, Q., Deng, T.T., You, J., Zhou, X.F., Zhang, W.J., Lou, J.N., Zhang, W.J. C-peptide ameliorates renal injury in type 2 diabetic rats through protein kinase A-mediated inhibition of fibronectin synthesis. Biochemical and Biophysical Research Communications 2015; 458(--):674-680. >>> C-peptide; IP; Rat; 2004; Controls received mp w/ saline, isotonic; animal info (male, GK, 8 weeks old); pumps replaced every 4 weeks; long-term study; cardiovascular; peptides; diabetes;.

14374 Rossdeutscher, L., Li, J., Luco, A.L., Fadhil, I., Ochietti, B., Camirand, A., Huang, D.C., Reinhardt, T.A., Muller, W., Kremer, R., Kremer, R. Chemoprevention Activity of 25-Hydroxyvitamin D in the MMTV-PyMT Mouse Model of Breast Cancer. Cancer Prevention Research 2015; 8(--):120-128. >>> Dihydroxycholecalciferol, 1,25-; hydroxycholecalciferol, 25-,; Ethanol; saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (female, MMTV-PyMT, 4 weeks old); functionality of mp verified by blood levels; pumps replaced every 4 weeks; 20% ethanol used; cancer (breast); long-term study;.

14373 Rosin, N.L., Sopel, M.J., Falkenham, A., Lee, T.D.G., Legare, J.F., Legare, J.F. Disruption of Collagen Homeostasis Can Reverse Established Age-Related Myocardial Fibrosis. American Journal of Pathology 2015; 185(--):631-642. >>> Aminopropionitrile, B-; SC; Mice; Controls received mp w/ saline; animal info (male, C57BL6J, 38 weeks old); pumps replaced every 7 days; cardiovascular; B-aminopropionitrile aka BAPN; enzyme inhibitor (nonreversible LOX inhibitor);.

14285 Lo, J.O., Schabel, M.C., Roberts, V.H.J., Morgan, T.K., Rasanen, J.P., Kroenke, C.D., Shoemaker, S.R., Spindel, E.R., Frias, A.E., Lo, J.O. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. American Journal of Obstetrics and Gynecology 2015; 212(--):U271-U278. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Monkey (macaque, pregnant); 2ML4; Controls received mp w/ vehicle; animal info (female, Rhesus, pregnant, GD26); functionality of mp verified by blood levels; pumps replaced every 3 weeks; post op. care (cefazolin 150 mg BID); long-term study; teratology; dependence;.

14282 Liu, Y.J., Ju, T.C., Chen, H.M., Jang, Y.S., Lee, L.M., Lai, H.L., Tai, H.C., Fang, J.M., Lin, Y.L., Tu, P.H., Chern, Y.J., Chern, Y.J. Activation of AMP-activated protein kinase alpha1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. Human Molecular Genetics 2015; 24(--):787-801. >>> JMF1907; Saline; SC; Mice (transgenic); Controls received mp w/ vehicle; animal info (B6SJL-Tg, 6 weeks old); pumps replaced every 4 weeks; neurodegenerative (Amyotrophic lateral sclerosis); no stress (see pg. 792); behavioral testing (rotarod, forelimb grip); long-term study;.

14698 Cifuentes, D., Poittevin, M., Dere, E., Broqueres-You, D., Bonnin, P., Benessiano, J., Pocard, M., Mariani, J., Kubis, N., Merkulova-Rainon, T., Levy, B.I., Levy, B.I. Hypertension Accelerates the Progression of Alzheimer-Like Pathology in a Mouse Model of the Disease. Hypertension 2015; 65(--):218-+. >>> Angiotensin II; SC; Mice; 2006; Animal info (male, APPPS1 heterozygous, 7 weeks old); pumps replaced every 6 weeks; neurodegenerative (Alzheimer's disease); behavioral testing (memory test, locomotor activity; long-term study; cardiovascular; peptides; bp measured using tail cuff;.

15265 Kato, G., Shimizu, Y., Arai, Y., Suzuki, N., Sugamori, Y., Maeda, M., Takahashi, M., Tamura, Y., Wakabayashi, N., Murali, R., Ono, T., Ohya, K., Mise-Omata, S., Aoki, K., Aoki, K. The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study. ARTHRITIS RESEARCH&THERAPY 2015; 17(--):U2-U15. >>> Peptide, OP3-4; PBS; DMSO; SC; Mice; Controls received mp w/ vehicle; animal info (male, DBA/1J, 7 weeks old); pumps replaced after day 35 or 42; 20% DMSO used; peptides;"a sustained-release carrier for OP3-4 needs to be developed since peptide drugs are unstable and aggregate easily in vivo. The effects of OP3-4 in this study were achieved using infusion pumps"pg 13.

14664 Aprahamian, T.R., Zhong, X.M., Amir, S., Binder, C.J., Chiang, L.K., Al-Riyami, L., Gharakhanian, R., Harnett, M.M., Harnett, W., Rifkin, I.R., Aprahamian, T.R. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. International Journal for Parasitology 2015; 45(--):203-207. >>> ES-62; PBS; Mice; Controls received mp w/ vehicle; animal info (male, Gld.apoE -/-); pumps replaced every 3 weeks; long-term study; cardiovascular; immunology; ES-62 is a phosphorylcholine-containing glycoprotein;.

13682 Llorens-Martin, M., Jurado-Arjona, J., Avila, J., Hernandez, F., Hernandez, F. Novel connection between newborn granule neurons and the hippocampal CA2 field. Experimental Neurology 2015; 263(--):285-292. >>> Endotoxin, LPS; PBS; SC; Mice; 1004; Animal info (female, 8 wks old, C57BL/6JRcc); long-term delivery; pumps replaced after 4 weeks.

 

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying...

“In summary, our data demonstrate that the local microinfusion of endostatin is able to inhibit tumor growth and increase survival of animals with orthotopic malignant gliomas. Local continuous i.c. delivery is more effective than daily systemic delivery.” (p.1255) Schmidt et al., Clinical Cancer Research 2004;10:1255-1262.