References on the Administration of Erythropoietin Using ALZET^® Osmotic Pumps

Q0577 Kondo,A., Shingo,T., Yasuhara,T., Kuramoto,S., Kameda,M., Kikuchi,Y., Matsui,T., Miyoshi,Y., Agari,T., Borlongan,C.V., Date,I. Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Brain Research 2009; 1296(-;-):127-136. >>> Erythropoietin, human, recomb.; antibody, anti-EPO; Saline; CSF/CNS; Rat; 6 days; 24 hours; Controls received mp w/ rat serum albumin, or control mouse IgG; animal info (male, Fischer 344, 10-12 wks old, 200-250 g, SLC).

Q0293 Jobst,B.J., Riegger,G.A.J., Griese,D.P. Endothelial Cell Seeding Fails to Prevent Intimal Hyperplasia Following Arterial Injury in the Rat Carotid Model. Cardiovascular Drugs and Therapy 2009; 23(-5-):343-353. >>> Granulocyte colony stimulating factor, human, recomb.; erythropoietin, human, recomb.; IP; Rat; 2ML1; 48 hours; Controls received mp w/ saline; animal info (male, CD, 250 g, splenectomy).

Q0263 Jing,M., Shingo,T., Yasuhara,T., Kondo,A., Morimoto,T., Wang,F.F., Baba,T., Yuan,W.J., Tajiri,N., Uozumi,T., Murakami,M., Tanabe,M., Miyoshi,Y., Zhao,S.G., Date,I. The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting. Brain Research 2009; 1295(-;-):203-217. >>> Erythropoietin, human, recomb.; Saline; albumin, rat serum; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, 190-210 g).

Q0248 Kolb,B, Morshead,C., Gonzalez,C., Kim,M., Gregg,C., Shingo,T., Weiss,S. Growth factor-stimulated generation of newcortical tissue and functional recovery after strokedamage to the motor cortex of rats. Journal of Cerebral Blood Flow and Metabolism 2007; 27(--):983-997. >>> Erythropoietin; epidermal growth factor; CSF, artificial; CSF/CNS; Rat; 2001; 7, 14 days; Controls received mp w/ vehicle; peptides; no stress (see pg. 984); animal info (male, Long-Evans, 90-110 days old); ischemia (cerebral); behavioral testing (forelimb assymetry, forelimb inhibition (swimming), reaching); some animals received 7 days EGF followed by 7 days EPO (most likely via Lynch Coil, but authors do not state).

P9496 Kadota,T., Shingo,T., Yasuhara,T., Tajiri,N., Kondo,A., Morimoto,T., Yuan,W.J., Wang,F.F., Baba,T., Tokunaga,K., Miyoshi,Y., Date,I. Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis. Brain Research 2009; 1254(-;-):120-127. >>> Erythropoietin; Albumin, rat serum; saline; CSF/CNS; Rat; 2001; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 220-250 g.).

P9369 Belayev,L., Khoutorova,L., Zhao,K.L., Davidoff,A.W., Moore,A.F., Cramer,S.C. A novel neurotrophic therapeutic strategy for experimental stroke. Brain Research 2009; 1280(-;-):117-123. >>> Erythropoietin; Saline; IV (femoral); Rat; 2ML1; 3 days; Controls received mp w/ vehicle; animal info (male, Long-Evans, 280-330 g., MCAO).

P9049 Hack,M., Mascha,F.G., Jobst,B.J., Riegger,G.A.J., Griese,D.P. A systemic combination therapy with granulocyte-colony stimulating factor plus erythropoietin aggravates the healing process of balloon-injured rat carotid arteries. Cardiovascular Drugs and Therapy 2008; 22(-5-):351-362. >>> Granulocyte colony-stimulating factor, recomb. human; erythropoietin; IP; Rat; 2ML1; 7 days; Controls received mp w/ saline; peptides; animal info (male, Sprague Dawley, 300-350 g., splenectomy); "We used implantable osmotic minipumps to guarantee continuous systemic delivery of the tested cytokines over the first even days upon intraperitoneal deposition." pg. 353.

P8932 Oya,S., Yoshikawa,G., Takai,K., Tanaka,J.I., Higashiyama,S., Saito,N., Kirino,T., Kawahara,N. Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia. NeuroReport 2008; 19(-8-):805-810. >>> Epidermal growth factor, recomb. human; fibroblast growth factor-2, recomb. human; insulin-like growth factor I, recomb. human; erythropoietin, recomb. rat; brain-derived neurotrophic factor, recomb. human; DDL4, recomb. mouse; CSF/CNS; Rat; 1003D; 3 days; Ischemia; animal info (male, Wistar, 8wks old, 280-300 g.); bilateral infusion.

P8660 Soliz,J., Gassmann,M., Joseph,V. Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia. JOURNAL OF PHYSIOLOGY-LONDON 2007; 583(-1-):329-336. >>> Erythropoietin receptor, soluble; Phosphate buffer; CSF/CNS; Mice; 1003D; 3 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male C57/BL6, 3 months old, hypoxia).

P8429 Frederiksen,B.L., Caye-Thomasen,P., Lund,S.P., Wagner,N., Asal,K., Olsen,N.V., Thomsen,J. Does erythropoietin augment noise induced hearing loss?. Hearing Research 2007; 223(-1-2-):129-137. >>> Erythropoietin; Ear (round window); Guinea-Pig; 1007D; 1 week; Controls received mp w/ saline; replacement therapy (noise-induced hearing impairment); comparison of acute admin. vs. mp; peptides; animal info (male, Dunkin-Hartley); tissue perfusion (round window); mp primed 6 hours in 37 Celsius saline; correct catheter placement confirmed.

P7614 Malhotra,S., Savitz,S.I., Ocava,L., Rosenbaum,D.M. Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack. Journal of Neuroscience Research 2006; 83(-1-):19-27. >>> Erythropoietin receptor, soluble; PBS; BSA; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (male, Wistar, 200-225 g); MCAO.

P5948 Prass,K., Scharff,A., Ruscher,K., Loewl,D., Muselmann,C., Victorov,I., Kapinya,K., Dirnagl,U., Meisel,A. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003; 34(-8-):1981-1986. >>> Erythropoietin, soluble receptor; PBS; BSA; CSF/CNS; Mice; 1003D; 64 hours; Controls received mp w/ vehicle; peptides; ischemia (cerebral); human EPO used; 0.1%BSA used in vehicle.

P5801 Shingo,T., Sorokan,S.T., Shimazaki,T., Weiss,S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 2001; 21(-24-):9733-9743. >>> Erythropoietin; antibody, rabbit anti-EPO neutralizing; rabbit IgG; Saline; albumin, mouse serum; rat serum; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; peptides; Erythropoietin (EPO) Recomb. Human, antibody&IgG were dissolved in 0.9% saline with 1 mg/ml mouse serum albumin; pump/cannula schematic (p. 9739 fig A).

P4619 Walker,B.R., Resta,T.C, Nelin,L.D  Am.J.Physiol.(Heart Circ.Physiol.) 2000; 279(--):H2382-H2389. >>> Erythropoietin; Saline; rat; 2 weeks; controls received mp w/vehicle; peptides; cardiovascular.

P4291 Roeder,I., de Haan,G., Engel,C., Nijhof,W., Dontje,B., Loeffler,M. Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 1998/5/1; 91(-9-):3222-3229. >>> Interleukin-11; Stem cell factor; Colony-stimulating factor, G; Erythropoietin;; SC;; mice;; 2002; 1007D;; 7 days;; controls received mp w/ saline; functionality of mp verified by pilot studies; no stress (see pg. 3223); peptides; recomb. human interleukin-11, EPO,&G-CSF used; recomb. rat stem cell factor used (pegylated);agents were given in every combination;.

P2970 Shibata,T., Kindler,V., Chicheportiche,Y., Vassalli,P., Izui,S. Interleukin 3 perfusion prevents death due to acute anemia induced by monoclonal antierythrocyte autoantibody. J.Exp.Med. 1990; 171(--):1809-1814. >>> Interleukin-3; Colony-stimulating factor, GM; Erythropoietin; PBS; Glycerol; LPS, e. coli; SC; mice; 2002; no duration posted; controls received mp with vehicles +/- LPS; immunology; peptides; recomb. mouse GM-CSF&IL-3 used; recomb. human EPO used.

P2737 Hoffman,A., Nyska,A., Avramoff,A., Golomb,G. Continuous versus pulsatile administration of erythropoietin (EPO) via the uterus in anemic rats. Int.J.Pharmaceutics 1994; 111(--):197-202. >>> Erythropoietin; intrauterine; rat; 2002; 5 days; controls received intrauterine bolus of saline; replacement therapy (gentamicin-induced anemia); comparison of iv bolus and intrauterine bolus vs. mp; peptides; mp implanted subdermally in abdomen; "administration of drug at a constant rate produces considerably greater biological effect than that observed in the pulsatile mode." (pg. 200); tissue perfusion (uterus); recomb. human EPO used.

P2546 de Haan,G., Engel,C., Dontje,B., Loeffler,M., Nijhof,W. Hemotoxicity by prolonged etoposide administration to mice can be prevented by simultaneous growth factor therapy. Cancer Res. 1995; 55(--):324-329. >>> Erythropoietin; Colony-stimulating factor, G; Etoposide; SC; mice; 7 days; dose-response curves (pg. 326-328); cancer; peptides; etoposide is VP-16-213; EPO and VP-16-213 given in same pump initially, but this inactived the G-CSF; multiple pumps per animal (1-2) for G-CSF/VP-16 mice.

P2523 Berney,T., Shibata,T., Merino,R., Chicheportiche,Y., Kindler,V., Vassalli,P., Izui,S. Murine autoimmune hemolytic anemia resulting from Fc-gamma receptor-mediated erythrophagocytosis: protection by erythropoietin but not by interleukin-3, and aggravation by granulocyte-macrophage colony-stimulating factor. Blood 1992; 79(-11-):2960-2964. >>> Erythropoietin; Interleukin-3; Colony-stimulating factor, GM; PBS; Glycerol; SC; mice; 2002; 14 days; immunology; peptides.

P0016 McGarry,M.P., Styles,B.D. Application of continuous flow osmotic minipumps in the study of hemopoietic regulators. Exp.Hematol. 1978; 6(-10-):809-811. >>> Erythropoietin; SC; Mice; 1701; 7; comparison of injections vs. mp infusion; peptides.