References on the Administration of Follicle Stimulating Hormone Using ALZET® Osmotic Pumps

10530 Zhou, W., Bolden-Tiller, O.U., Shetty, G., Shao, S.H., Weng, C.C., Pakarinen, P., Liu, Z.L., Stivers, D.N., Meistrich, M.L. Changes in Gene Expression in Somatic Cells of Rat Testes Resulting from Hormonal Modulation and Radiation-Induced Germ Cell Depletion. Biology of Reproduction 2010; 82(-1-):54-65. >>> Follicle stimulating hormone, human, recomb.; SC; Rat; 2001; Animal info (LBNF1, male); pumps replaced after 1 week.

10084 Ritter, V., Thuering, B., Saint Mezard, P., Luong-Nguyen, N.H., Seltenmeyer, Y., Junker, U., Fournier, B., Susa, M., Morvan, F. Follicle-stimulating hormone does not impact male bone mass in vivo or human male osteoclasts in vitro. Calcified Tissue International 2008; 82(-5-):383-391. >>> Follicle stimulating hormone; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, C57BL/6J, 16 wks old).

8342 Filipiak, W.E., Saunders, T.L. Advances in transgenic rat production. TRANSGENIC RESEARCH 2006; 15(-6-):673-686. >>> Follicle stimulating hormone, porcine; SC; Rat; 1003D; Comparison of SC injections vs. mp; peptides; animal info (female, Sprague-Dawley CD, 4-6 wk old).

7774 Popova, E., Bader, M., Krivokharchenko, A. Strain differences in superovulatory response, embryo development and efficiency of transgenic rat production. TRANSGENIC RESEARCH 2005; 14(-5-):729-738. >>> Follicle stimulating hormone; SC; Rat; 2001; Comparison of PMSG by IP injections vs. mp; peptides; animal info (female Lewis, Wistar-Kyoto, SHRSP, Sprague-Dawley, 28-35 days old).

7713 Shetty, G., Weng, C.C.Y., Meachem, S.J., Bolden-Tiller, O.U., Zhang, Z., Pakarinen, P., Huhtaniemi, I., Meistrich, M.L. Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats. Endocrinology 2006; 147(-1-):472-482. >>> Follicle stimulating hormone, recomb. human; PBS; SC; Rat; 2001; Controls received sham implant; pumps replaced every week; animal info (male LBNF1, 9-12 wk old); testes irradiated.

5453 Popova, E., Krivokharchenko, A., Ganten, D., Bader, M. Comparison between PMSG- and FSH-induced superovulation for the generation of transgenic rats. MOLECULAR REPRODUCTION AND DEVELOPMENT 2002; 63(-2-):177-182. >>> Follicle stimulating hormone; SC; Rat; 2001; .

5416 Corbin, T.J., McCabe, J.G. Strain variation of immature female rats in response to various superovulatory hormone preparations and routes of administration. Contemp. Top. Lab Anim Sci 2002; 41(-2-):18-23. >>> Follicle stimulating hormone; SC; Rat; Comparison of ip injections vs. mp; endocrinology.

5380 Mullins, L.J., Brooker, G., Mullins, J.J. Transgenesis in the rat. Methods Mol. Biol 2002; 180(--):255-270. >>> Follicle stimulating hormone; Saline; SC; Rat; 1003D; Detailed procedures for priming and surgery.

5221 Duggal, P.S., Ryan, N.K., Van der Hoek, K.H., Ritter, L.J., Armstrong, D.T., Magoffin, D.A., Norman, R.J. Effects of leptin administration and feed restriction on thecal leucocytes in the preovulatory rat ovary and the effects of leptin on meiotic maturation, granulosa cell proliferation, steroid hormone and PGE(2) release in cultured rat ovarian follicles. REPRODUCTION 2002; 123(--):891-898. >>> Follicle stimulating hormone; Saline; SC; rat; human FSH used; endocrinology.

4835 Duggal, P.S, Van Der Hoek, K.H, Milner, C.R, Ryan, N.K, Armstrong, D.T., Magoffin, D.A, Norman, R.J  Endocrinology 2000; 141(-6-):1971-1976. >>> Follicle stimulating hormone, human;; Saline;; SC;; rat;; Controls received mp w/ vehicle; functionality of mp verified by plasma progesterone and estradiol levels (result of FSH administration); peptides;.

3898 Leveille, M.-C., Armstrong, D.T. Preimplantation embryo development and serum steroid levels in immature rats induced to ovulate or superovulate with pregnant mares'serum gonadotropin injection of follicle-stimulating hormone infusions. Gamete Res 1989; 23(--):127-138. >>> Follicle stimulating hormone, porcine; Gonadotrophin, human chorionic; Saline, sterile; SC; rat; 2001; comparison of sc PMSG injections vs. mp; peptides.

3772 Brussow, K-P., Torner, H., Ratky, J., Schneider, F., Kanitz, W., Kochling, W. Aspects of follicular development and intrafollicular oocyte maturation in gilts. Reprod. Dom. Anim 1996; 31(--):555-563. >>> Follicle stimulating hormone, porcine; pig; 2ML1; controls received mp w/ saline.

3639 Treloar, A.F., Schabdach, D.G., Sansing, S., Keller, L.S. Superovulation of New Zealand white rabbits by continuous infusion of follicle-stimulating hormone, using a micro-osmotic pump. Lab. Anim. Sci 1997; 47(-3-):313-316. >>> Follicle stimulating hormone; SC; rabbit; 1003D; functionality of mp verified by serum levels; peptides.

3367 Matikainen, T., Toppari, J., Vihko, K.K., Huhtaniemi, I. Effects of recombinant human FSH in immature hypophysectomized male rats: evidence for leydig cell-mediated action on spermatogenesis. J. Endocrinol 1994; 141(--):449-457. >>> Follicle stimulating hormone, recomb. human; PBS; rat; controls received mp w/saline; replacement therapy (hypophysectomy); peptides.

3362 LaPolt, P.S., Tilly, J.L., Aihara, T., Nishimori, K., Hsueh, A.J.W. Gonadotropin-induced up- and down-regulation of ovarian follicle-stimulating hormone (FSH) receptor gene expression in immature rats: effects of pregnant mare's serum gonadotropin, human chorionic gonadotropin, and recombinant FSH. Endocrinology 1992; 130(-3-):1289-1295. >>> Follicle stimulating hormone; SC; rat; replacement therapy (hypophysectomy); peptides.

3241 Tapanainen, J.S., LaPolt, P.S., Perlas, E., Hsueh, A.J.W. Induction of ovarian follicle luteinization by recombinant follicle-stimulating hormone. Endocrinology 1993; 133(-6-):2875-2880. >>> Follicle stimulating hormone, recomb.; rat; replacement therapy (hypophysectomy); peptides.

2420 Meseguer, A., Catterall, J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol. and Cellular Endocrin 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

2550 Ishimatsu, M., Nakamura, Y., Kato, H. Continuous luteinizing hormone infusion prevents atretic changes of the follicles during superovulation in hamsters. Endocrine J 1993; 40(--):665-671. >>> Follicle stimulating hormone, human; Luteinizing hormone; PBS; Albumin, bovine serum; SC; hamster; 2001; controls received mp w/ vehicles only; agents infused alone and in combination; human LH used.

2042 Vihko, K.K., LaPolt, P.S., Nishimori, K., Hsueh, A.J.W. Stimulatory effects of recombinant follicle-stimulating hormone on leydig cell function and spermatogenesis in immature hypophysectomized rats. Endocrinology 1991; 129(-4-):1926-1932. >>> Follicle stimulating hormone; PBS; SC; rat; replacement therapy (hypophysectomy).

1947 Hamilton, G.S., Armstrong, D.T. The superovulation of synchronous adult rats using follicle-stimulating hormone delivered by continuous infusion. Biol. Reprod 1991; 44(--):851-856. >>> Follicle stimulating hormone; Gonadotrophin, human chorionic; SC; rat; 2001; peptides.

1855 Carnegie, J.A. Immunolocalization of fibronectin and laminin within rat blastocysts cultured under serum-free conditions. J. Reprod. Fertil 1991; 91(--):423-434. >>> Follicle stimulating hormone; Gonadotrophin, human chorionic; Saline; SC; rat; 2001; pumps removed and reimplanted into different animals.

1811 Armstrong, D.T., Opavsky, M.A. Superovulation of immature rats by continuous infusion of follicle-stimulating hormone. Biol. Reprod 1988; 39(--):511-518. >>> Follicle stimulating hormone; rat; 2001; comparison of bid sc injections vs. mp;'short half-life of FSH-A requires...continuous infusion...results establish the efficacy of FSH in causing superovulation when infused continuously.'(p.517).

1801 Galway, A.B., LaPolt, P.S., Tsafriri, A., Dargan, C.M., Boime, I., Hsueh, A.J.W. Recombinant follicle-stimulating hormone induces ovulation and tissue plasminogen activator expression in hypophysectomized rats. Endocrinology 1990; 127(-6-):3023-3028. >>> Follicle stimulating hormone; SC; rat; no comment posted.

1760 Wubishet, A., Kesler, D.J., Graves, C.N., Spahr, S.L., Favero, R.J. Preovulatory LH profiles of superovulated cows and progesterone concentrations at embryo recovery. Theriogenology 1991; 35(-2-):451-457. >>> Follicle stimulating hormone; SC; cattle; no comment posted.

1752 Henderson, K.M., Weaver, A., Wards, R.L., Ball, K., Lun, S., Mullin, C., McNatty, K.P. Oocyte production and ovarian steroid concentrations of immature rats in response to some commercial gonadotrophin preparations. Reprod. Fertil. Dev 1990; 2(--):671-682. >>> Luteinizing hormone; Follicle stimulating hormone; SC; rat; 2001; FSH-P, Folltropin, Oragen, Folligon; horse and porcine LH used.

1695 Keeney, D.S., Sprando, R.L., Robaire, B., Zirkin, B.R., Ewing, L.L. Reversal of long-term LH deprivation on testosterone secretion and Leydig cell volume, number and proliferation in adult rats. J. Endocrinol 1990; 127(--):47-58. >>> Luteinizing HRH; Follicle stimulating hormone, ovine; SC; rat; 2002; peptides; ovine LHRH used.

1517 Rivier, C., Vale, W. Immunoneutralization of endogenous inhibin modifies hormone secretion and ovulation rate in the rat. Endocrinology 1989; 125(-1-):152-157. >>> Follicle stimulating hormone, ovine; Albumin, bovine serum; PBS; IP; rat; 2001; dose-response; functionaltiy of mp verified by plasma levels.

1238 Milette, J.J., Schwartz, N.B., Turek, F.W. The importance of follicle-stimulating hormone in the initiation of testicular growth in photostimulated djungarian hamsters. Endocrinology 1988; 122(--):1060-1066. >>> Follicle stimulating hormone, ovine; Luteinizing hormone; Saline; IP; hamster; 2001; controls left untreated; dose-response (graph); peptides; ovine LH used.

858 Wubishet, A., Graves, C.N., Spahr, S.L., Kesler, D.J. Continuous subcutaneous infusion of follicle stimulating hormone as a method of superovulating dairy cows. Theriogenology 1986; 25(-6-):809-812. >>> Follicle stimulating hormone; Saline; SC; cattle; 2ML1; comparison of im injections vs. mp infusion; peptides.

520 Garza, F., Shaban, M.A., Terranova, P.F. Luteinizing hormone increases the number of ova shed in the cyclic hamster and guinea-pig. J. Endocrinol 1984; 101(--):289-298. >>> Gonadotrophin, pregnant mare serum; Luteinizing hormone; Follicle stimulating hormone, ovine; Gonadotrophin, human chorionic; Albumin, bovine serum; PBS; SC; guinea-pig; hamster; mice; rat; 2001; comparison of agents effects; replacement therapy (hypophysectomy); agents admin. singly; peptides; bovine, ovine,&human LH used.

322 Ewing, L.L., Wing, T.-Y., Cochran, R.C., Kromann, N., Zirkin, B.R. Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 1983; 112(-5-):1763-1769. >>> Follicle stimulating hormone; Growth hormone, ovine; Luteinizing hormone; Prolactin, ovine; Thyroid-stimulating hormone; Borate; Peanut oil; SC; rat; replacement therapy (hypophysectomy); simultaneous infusion of testosterone&estradiol implants w/ mp infusion of polypeptides; pulsed delivery of agents (intermittent w/ vehicle); peptides; ovine LH used.


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“Continuous release of albuterol subcutaneously with a miniosmotic pump resulted in a sustained high plasma albuterol concentration throughout the entire experimental period.” Sartori et al., J Appl Physiol 2002;93:1875-1880.