References Which Document ALZET® Osmotic Pump Functionality

Q2182 DeClercq,V., Taylor,C.G., Wigle,J., Wright,B., Tworek,L., Zahradka,P. Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2012; 23(-5-):487-493. >>> Adiponectin; SC; Rat; 2001; 7 days; Controls received mp w/ saline; animal info (Zucker, 16 wks old, fa/fa); functionality of mp verified by plasma adiponectin levels; comparison of sc mp versus bolus injections; A bolus injection of adiponectin had no effect on systolic blood pressure compared with saline... In contrast, when adiponectin was infused continuously for 7 days, systolic blood pressure was improved compared with saline-treated rats..." pg 490; antihypertensive; obesity.

Q2189 Portugal,G.S., Wilkinson,D.S., Turner,J.R., Blendy,J.A., Gould,T.J. Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning. NEUROBIOLOGY OF LEARNING AND MEMORY 2012; 97(-4-):482-494. >>> Nicotine; Saline, physiological; SC; Mice; 1002; 12 days; Controls received mp w/ vehicle; animal info (male, C57BL/6J, PND 23, 38, 53); functionality of mp verified by residual volume; behavioral testing (fear conditioning).

Q1633 Schmid,H.A., Brueggen,J. Effects of somatostatin analogs on glucose homeostasis in rats. Journal of Endocrinology 2012; 212(-1-):49-60. >>> Pasireotide acetate; Saline, sterile; SC; Rat; 2ML2; 14 days; Animal info (Lewis, male, adult, 300-340 g); functionality of mp verified by plasma drug levels.

Q2174 Simard,J.M., Woo,S.K., Tsymbalyuk,N., Voloshyn,O., Yurovsky,V., Ivanova,S., Lee,R., Gerzanich,V. Glibenclamide-10-h Treatment Window in a Clinically Relevant Model of Stroke. TRANSLATIONAL STROKE RESEARCH 2012; 3(-2-):286-295. >>> Glibenclamide; DMSO; saline; NaOH; SC; Rat; 2001; 48 hours; Controls received mp w/ vehicle; animal info (Wistar, male, 250-275 g); 5.5 hour delayed delivery accomplished by connecting 5.5 ul volume PE60; functionality of mp verified by residual volume; 8% DMSO used; stability verified via spectrophotometry; ischemia (cerebral).

Q1473 Brown,A.J., Ritter,C.S. The Vitamin D Analog 1-alpha,25-Dihydroxy-2-beta-(3-Hydroxypropyloxy) Vitamin D3 (Eldecalcitol) is a Potent Regulator of Calcium and Phosphate Metabolism. Calcified Tissue International 2011; 89(-5-):372-378. >>> Parathyroid hormone (1-34); SC; Rat; ; Animal info (female, Sprague-Dawley, 225-250 g); hormone replacement (parathyroidectomy); functionality of mp verified by plasma PTH levels.

Q1454 Chou,C.L., Lai,Y.H., Lin,T.Y., Lee,T.J.F., Fang,T.C. Aliskiren prevents and ameliorates metabolic syndrome in fructose-fed rats. Archives of Medical Science 2011; 7(-5-):882-888. >>> Aliskiren; Saline, normal; SC; Rat; 2002; 4 weeks; animal info (male, Sprague-Dawley, 200-230 g); pumps replaced after 2 weeks; functionality of mp verified by residual volume; post op care (penicillin).

Q1050 Engholm,M., Eftekhari,A., Chwatko,G., Bald,E., Mulvany,M.J. Effect of Cystamine on Blood Pressure and Vascular Characteristics in Spontaneously Hypertensive Rats. JOURNAL OF VASCULAR RESEARCH 2011; 48(-6-):476-484. >>> Cystamine; amlodipine; Saline, sterile; PEG 400; water, sterile; SC; Rat; 2ML2; 3 weeks; Controls received mp w/ vehicle; animal info (adulit, SHR, 14 wks old, 293 g); functionality of mp verified by plasma cystamine levels; pumps replaced after 12 days; enzyme inhibitor (tissue transglutaminase).

Q1062 Fang,M.R., Wang,J., Huang,J.Y., Ling,S.C., Rudd,J.A., Hu,Z.Y., Yew,D.T., Han,S. The Neuroprotective Effects of Reg-2 Following Spinal Cord Transection Injury. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 2011; 294(-1-):24-45. >>> Regeneration gene protein 2; ciliary neurotrophic factor; Saline; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001D; 2001; 7 days; 24 hours; Controls received mp w/ vehicle; animal info (adult, female, 200-250 g, Sprague Dawley); functionality of mp verified by residual volume; spinal cord injury.

Q1119 Henderson,WR Jr, Oslund,R.C., Bollinger,J.G., Ye,X., Tien,Y.T., Xue,J., Gelb,M.H. Blockade of Human Group X Secreted Phospholipase A(2) (GX-sPLA(2))-induced Airway Inflammation and Hyperresponsiveness in a Mouse Asthma Model by a Selective GX-sPLA(2) Inhibitor. Journal of Biological Chemistry 2011; 286(-32-):28049-28055. >>> RO061606; Dimethyl sulfate; propylene glycol; SC; Mice; 2001; ; Animal info (C57BL/6J, wt); functionality of mp verified by plasma concentrations; enzyme inhibitor (Group X phospholipase A2); multiple pumps per animal (2).

Q1129 Iannotti,C.A., Clark,M., Horn,K.P., van Rooijen,N., Silver,J., Steinmetz,M.P. A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI. Experimental Neurology 2011; 230(-1-):3-15. >>> Rolipram; DMSO; SC; Rat; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (adult, female, Sprague Dawley, 220-250 g); functionality of mp verified; pumps replaced after 1 week; post op. care (hydration with normal saline (10 cc), buprenex, cephalozolin).

Q1477 Laeremans,H., Hackeng,T.M., van Zandvoort,M.A.M.J., Thijssen,V.L.J.L., Janssen,B.J.A., Ottenheijm,H.C.J., Smits,J.F.M., Blankesteijn,W.M. Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction. Circulation 2011; 124(-15-):1626-U107. >>> UM206; UM206 analog; SC; Mice; 2002; 2006; 2, 5 weeks; Controls received mp w/ saline; functionality of mp verified by plasma UM206 levels; animal info (male, Swiss, 10-12 wks old).

Q1195 Leake,P.A., Hradek,G.T., Hetherington,A.M., Stakhovskaya,O. Brain-Derived Neurotrophic Factor Promotes Cochlear Spiral Ganglion Cell Survival and Function in Deafened, Developing Cats. Journal of Comparative Neurology 2011; 519(-8-):1526-1545. >>> Brain-derived neurotrophic factor, human; Perilymph, artificial; Ear (cochlea); Cat; 1002; 2004; 10 weeks; Controls received mp w/ vehicle; long-term study; animal info (adult, 4 wks old, deafened); functionality of mp verified via residual volume; pumps replaced after two weeks then after 28 days; tissue perfusion (cochlea); "The drug-delivery cannula within the cochlear implant... was connected to vinyl tubing..., which was connected to the regulator of the osmotic pump, which was implanted behind the right pinna."; artificial perilymph recipe.

Q1200 Lee,M.H., Wang,T.G., Jang,M.H., Steiner,J., Haughey,N., Ming,G.L., Song,H.J., Nath,A., Venkatesan,A. Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease. NEUROBIOLOGY OF DISEASE 2011; 41(-3-):678-687. >>> Paroxetine; SC; Mice; 2004; 28 days; Animal info (8-9 wks old, gp120-tg, wt); functionality of mp verified by residual volume.

Q1225 Lymperi,S., Ersek,A., Ferraro,F., Dazzi,F., Horwood,N.J. Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood 2011; 117(-5-):1540-1549. >>> Parathyroid hormone (1-34); PBS, sterile; acetic acid; SC; Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (C57BL/6, female, 8-12 wks old); functionality of mp verified by PTH 1-34 levels in the blood serum; post op. care (Baytril and Rimadyl).

Q2201 Mateus,J., Bytautiene,E., Lu,F.X., Tamayo,E.H., Betancourt,A., Hankins,G.D.V., Longo,M., Saade,G.R. Endothelial growth factor therapy improves preeclampsia-like manifestations in a murine model induced by overexpression of sVEGFR-1. American Journal of Physiology-Heart and Circulatory Physiology 2011; 301(-5-):H1781-H1787. >>> Vascular endothelial growth factor 121; PBS; SC; Mice (pregnant); 2002; 10 days; Controls received mp w/ vehicle; animal info (CD-1); functionality of mp verified by residual volume and plasma drug levels.

Q1524 McQuillan,H.J., Kusakabe,M., Young,G. Effects of chronic manipulation of adrenocorticotropic hormone levels in Chinook salmon on expression of interrenal steroidogenic acute regulatory protein and steroidogenic enzymes. General and Comparative Endocrinology 2011; 174(-2-):156-165. >>> Adrenocorticotropic hormone; NaCl, sterile; IP; Fish (salmon); 1003D; 10 days; Controls received mp w/ vehicle; animal info (juvenile, Chinook); functionality of mp verified by plasma drug levels or visual inspection.

Q1233 Mraiche,F., Oka,T., Gan,X.H.T., Karmazyn,M., Fliegel,L. Activated NHE1 is required to induce early cardiac hypertrophy in mice. Basic Research In Cardiology 2011; 106(-4-):603-616. >>> Phenylephrine; PBS; SC; Mice; 2 weeks; Controls received mp w/ vehicle; animal info (10-12 wks old, NHE-1-tg); functionality of mp verified by residual volume.

Q0737 Pineda,E.A., Hensler,J.G., Sankar,R., Shin,D., Burke,T.F., Mazarati,A.M. Plasticity of Presynaptic and Postsynaptic Serotonin 1A Receptors in an Animal Model of Epilepsy-Associated Depression. Neuropsychopharmacology 2011; 36(-6-):1305-1316. >>> Mifepristone; DMSO; CSF/CNS (dorsal raphe); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 50 days old); functionality of mp verified by residual volume; 10% DMSO used.

Q1944 Rogers,J.T., Morganti,J.M., Bachstetter,A.D., Hudson,C.E., Peters,M.M., Grimmig,B.A., Weeber,E.J., Bickford,P.C., Gemma,C. CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity. Journal of Neuroscience 2011; 31(-45-):16241-16250. >>> Interleukin 1 receptor antagonist, metHu; CSF/CNS; Mice; 1004; 4 weeks; Controls received mp w/ artificial CSF; animal info (CX3CR1 -/-, C57BL6, male, 3 mo old); guide cannula used; functionality of mp verified via weighing pump after the experiment.

Q1484 Samson,S.L., Sathyanarayana,P., Jogi,M., Gonzalez,E.V., Gutierrez,A., Krishnamurthy,R., Muthupillai,R., Chan,L., Bajaj,M. Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. Diabetologia 2011; 54(-12-):3093-3100. >>> Exendin 4; PBS; albumin, mouse serum; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; animal info (DIO, 18 wks old); peptides; functionality of mp verified by plasma levels.

Q1326 Stroobants,S., Gerlach,D., Matthes,F., Hartmann,D., Fogh,J., Gieselmann,V., D'Hooge,R., Matzner,U. Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy. Human Molecular Genetics 2011; 20(-14-):2760-2769. >>> Arylsulfatase A, recomb. human; CSF, artificial; CSF/CNS; Mice; 2004; 4 weeks; WT controls received mp w/ vehicle; animal info (ASA KO, 6 mo old); functionality of mp verified by residual volume; ALZET brain infusion kit 3 used; half-life (p. 2766) "<10 min; "the present study demonstrates that, in contrast to intravenous ERT, i.c.v. ERT reverses previously intractable ataxic symptoms of MLD, requires less enzyme to clear more sulfatide from brain and has no adverse immunological effects." pg 2767; "The demonstrated therapeutic efficacy in MLD mouse models and the well-established clinical feasibility with miniaturized pump systems suggest that i.c.v. ERT could be a promising option for future treatment of MLD and other LSDs with CNS manifestations." pg 2767.

Q1474 Sugata,S., Hanaya,R., Kumafuji,K., Tokudome,M., Serikawa,T., Kurisu,K., Arita,K., Sasa,M. Neuroprotective effect of levetiracetam on hippocampal sclerosis-like change in spontaneously epileptic rats. Brain Research Bulletin 2011; 86(-1-2-):36-41. >>> Levetiracetam; Saline, physiological; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; animal info (spontaneously epileptic (SER), 4 wks old); functionality of mp verified by serum levetiracetam levels.

Q1336 Takeshima,Y., Nakamura,M., Miyake,H., Tamaki,R., Inui,T., Horiuchi,K., Wajima,D., Nakase,H. Neuroprotection With Intraventricular Brain-Derived Neurotrophic Factor in Rat Venous Occlusion Model. Neurosurgery 2011; 68(-5-):1334-1341. >>> Brain-derived neurotrophic factor; PBS; CSF/CNS; Rat; 2001; 2, 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 240-280 g); functionality of mp verified by residual volume; ALZET brain infusion kit 2 used.

Q1746 Velkoska,E., Dean,R.G., Griggs,K., Burchill,L., Burrell,L.M. Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy. Clinical Science 2011; 120(-7-8-):335-345. >>> Angiotensin (1-7);; Saline; SC; Rat; 2002; 10 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 200-250 g); functionality of mp verified via residual volume and ang (1-7) concentration in residual volume.

Q1431 West,C.H.K., Weiss,J.M. Effects of chronic antidepressant drug administration and electroconvulsive shock on activity of dopaminergic neurons in the ventral tegmentum. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 2011; 14(-2-):201-210. >>> Desipramine hydrochloride; imipramine hydrochloride; fluoxetine hydrochloride; paroxetine hydrochloride; sertraline hydrochloride; venlafaxine hydrochloride; bupropion hydrochloride; phenelzine sulfate; Polyethylene glycol; DMSO; water; water, distilled; SC; IP; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (male, albino, Sprague-Dawley, 550-700 g); functionality of mp verified by drug levels in circulation; good methods, pg 4; 25% DMSO used; IP catheter used; silastic tubing used; "The distal end of the silastic tubing, including the bulb, was then introduced surgically into the peritoneal cavity and the peritoneal wall sutured closed so that the bulb prevented the tubing from being withdrawn back into the subcutaneous space, thereby enabling... delivery of drug from the pump into the peritoneal cavity." pg 4;.

Q0847 Barb,C.R., Hausman,G.J., Kraeling,R.R. Luteinizing hormone secretion as influenced by age and estradiol in the prepubertal gilt. ANIMAL REPRODUCTION SCIENCE 2010; 122(-3-4-):324-327. >>> Estradiol benzoate; Propylene glycol; SC; Pig; 2ML2; ; Controls received mp w/ vehicle; animal info (gilt, OVX, 90, 150, 210 day old); functionality of mp verified by serum estradiol levels; replacement therapy (ovariectomized).

Q0002 Batista,D.G., Neves,K.R., Graciolli,F.G., dos Reis,L.M., Graciolli,R.G., Dominguez,W.V., Neves,C.L., Magalhaes,A.O., Custodio,M.R., Moyses,R.M., Jorgetti,V. The Bone Histology Spectrum in Experimental Renal Failure: Adverse Effects of Phosphate and Parathyroid Hormone Disturbances. Calcified Tissue International 2010; 87(-1-):60-67. >>> Parathyroid hormone, recomb. rat (1-34); Cysteine; SC; Rat; 2ML4; 56 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 280-330 g); functionality of mp verified by hormone serum levels; replacement therapy (parathyroidectomy, nephrecotomy (5/6)); pumps replaced after 28 days; long-term study.

Q0983 Boulamery,A., Simon,N., Vidal,J., Bruguerolle,B. EFFECTS OF L-DOPA ON CIRCADIAN RHYTHMS OF 6-OHDA STRIATAL LESIONED RATS: A RADIOTELEMETRIC STUDY. Chronobiology International 2010; 27(-2-):251-264. >>> Levodopa; Saline; SC; Rat; 2ML1; 7 days; Controls received mp w/ vehicle; animal info (Wistar, AF IOPS, male, 10 wks old, 275 g); functionality of mp verified by detecting metabolite levels via HPLC.

Q0987 Braden,B.B., Talboom,J.S., Crain,I.D., Simard,A.R., Lukas,R.J., Prokai,L., Scheldrup,M.R., Bowman,B.L., Bimonte-Nelson,H.A. Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats. NEUROBIOLOGY OF LEARNING AND MEMORY 2010; 93(-3-):444-453. >>> Progesterone; medroxyprogesterone acetate; Propylene glycol; SC; Rat; 2ML4; ; Controls received mp w/ vehicle; animal info (18 mo old, female, Fischer 344); functionality of mp verified by blood serum levels of MPA; pumps replaced every 31-32 days; behavioral testing (Morris maze test); replacement therapy (ovariectomy).

Q1012 Castoldi,G., di Gioia,C.R.T., Bombardi,C., Perego,C., Perego,L., Mancini,M., Leopizzi,M., Corradi,B., Perlini,S., Zerbini,G., Stella,A. Prevention of myocardial fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in diabetic rats. Clinical Science 2010; 118(-3-4-):211-220. >>> Ac-SDKP; SC; Rat; 2004; 2 months; Controls received mp w/ saline; animal info (STZ induced diabetes, Sprague Dawley); functionality of mp verified by plasma drug levels; peptides; Ac-SDKP is a physiological tetrapeptide; diabetes; long-term study.

Q0109 Chambliss,K.L., Wu,Q.A., Oltmann,S., Konaniah,E.S., Umetani,M., Korach,K.S., Thomas,G.D., Mineo,C., Yuhanna,I.S., Kim,S.H., Madak-Erdogan,Z., Maggi,A., Dineen,S.P., Roland,C.L., Hui,D.Y., Brekken,R.A., Katzenellenbogen,J.A., Katzenellenbogen,B.S., Shaul,P.W. Non-nuclear estrogen receptor-alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. Journal of Clinical Investigation 2010; 120(-7-):2319-2330. >>> Estradiol; estrogen-dendrimer conjugate; IP; Mice (nude); 3, 7 weeks; 72 hours; Controls received mp w/ empty dendrimer; cardiovascular; cancer (breast); animal info (female, ERE-Luc reporter, 10-13 weeks old; Ex3aERKO, 8-9 weeks old; C57BL/6 Apoe-/-, 6 weeks old; SCID, 8 weeks old); functionality of mp verified by serum agent levels; replacement therapy (ovariectomy; pumps replaced after 28 days); long-term study; photon recording with light emission tomography (LET) system with a CCD camera; Research Diets D10001.

Q0110 Chan,E.C., Dusting,G.J., Guo,N., Peshavariya,H.M., Taylor,C.J., Dilley,R., Narumiya,S., Jiang,F. Prostacyclin receptor suppresses cardiac fibrosis: Role of CREB phosphorylation. Journal of Molecular and Cellular Cardiology 2010; 49(-2-):176-185. >>> Angiotensin II; Saline; SC; Mice; 2 weeks; Controls received mp w/ vehicle; peptides; no stress (pg. 178); animal info (C57BL/6, ApoE-/-, IP-/-, IP+/+, 16-18 weeks old); functionality of mp verified by systolic blood pressure; dose-response (Table 1).

Q0148 Chen,J.J., Lue,J.H., Lin,L.H., Huang,C.T., Chiang,R.P.Y., Chen,C.L., Tsai,Y.J. Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury. Pain 2010; 148(--):158-166. >>> Fluorocitrate; CSF/CNS (cuneate nucleus); Rat; 2004; ; Controls received mp w/ vehicle; functionality of mp verified by residual volume; animal info (male, Sprague Dawley, 180-250 g.); 5 day surgical recovery period.

Q0008 Cho,Y.K., Eom,G.H., Kee,H.J., Kim,H.S., Choi,W.Y., Nam,K.I., Ma,J.S., Kook,H. Sodium Valproate, a Histone Deacetylase Inhibitor, but Not Captopril, Prevents Right Ventricular Hypertrophy in Rats. CIRCULATION JOURNAL 2010; 74(-4-):760-770. >>> Captopril; DMSO; SC; Rat; 14 days; Cardiovascular; enzyme inhibitor (ACE); animal info (male, Sprague-Dawley, 3 weeks old); functionality of mp verified by plasma ang I and ang II levels; right ventricular hypertrophy by pulmonary artery banding.

Q0112 de Oliveira,E., Moura,E.G., Santos-Silva,A.P., Pinheiro,C.R., Lima,N.S., Nogueira-Neto,J.F., Nunes-Freitas,A.L., breu-Villaca,Y., Passos,M.C.F., Lisboa,P.C. Neonatal nicotine exposure causes insulin and leptin resistance and inhibits hypothalamic leptin signaling in adult rat offspring. Journal of Endocrinology 2010; 206(-1-):55-63. >>> Nicotine, free base; Saline; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; teratology; functionality of mp verified by serum and milk cotinine levels; animal info (female, Wistar, lactating); endocrinology.

Q1065 Ferrand,A., Lachal,S., Bramante,G., Kovac,S., Shulkes,A., Baldwin,G.S. Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine. American Journal of Physiology-Gastrointestinal and Liver Physiology 2010; 299(-1-):G220-G227. >>> Gastrin, glycine-extended; PBS; BSA; IP; Rat; 2ML4; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300 g); functionality of mp verified by serum ggly levels; peptides.

Q0042 Fujimura,Y., Zoghbi,S.S., Simeon,F., Taku,A., Victor,P., Innis,R., Fujita,M. Quantification of peripheral benzodiazepine receptors in human brain with 18F-PBR06. Journal of Cerebral Blood Flow and Metabolism 2010; 29(--):S360-S375. >>> Nicotine; Monkey (baboon); 6 months; Long-term study; animal info (Papio anubis); functionality of mp verified by plasma nicotine concentration; pumps replaced at 15 days, 2, 3, 4 and 5 months.

Q1080 Garcia-Matas,S., de Vera,N., Aznar,A.O., Marimon,J.M., Adell,A., Planas,A.M., Cristofol,R., Sanfeliu,C. In Vitro and In Vivo Activation of Astrocytes by Amyloid-beta is Potentiated by Pro-Oxidant Agents. JOURNAL OF ALZHEIMERS DISEASE 2010; 20(-1-):229-245. >>> Protein, amyloid beta (40-1); protein, amyloid beta (42-1); buthionine sulfoximine; ferrous sulfate; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (3 mo old, male, Sprague Dawley, 300-350 g); functionality of mp verified; multiple pumps per animal (2); neurodegenerative (Alzheimer's disease).

Q0122 Huang,X.R., Chung,A.C.K., Yang,F.Y., Yue,W.S., Deng,C.X., Lau,C.P., Tse,H.F., Lan,H.Y. Smad3 Mediates Cardiac Inflammation and Fibrosis in Angiotensin II-Induced Hypertensive Cardiac Remodeling. Hypertension 2010; 55(-5-):1165-U153. >>> Angiotensin II; Saline; SC; Mice; 14 days; Controls received mp w/ vehicle; peptides; cardiovascular; animal info (C57BL/6 wt, Smad3 KO); functionality of mp verified by systolic blood pressure.

Q1545 Kimura,K., Kanazawa,H., Ieda,M., Kawaguchi-Manabe,H., Miyake,Y., Yagi,T., Arai,T., Sano,M., Fukuda,K. Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure. Autonomic Neuroscience-Basic&Clinical 2010; 156(-1-2-):27-35. >>> Norepinephrine; Saline; ascorbate; SC; Rat; mice; 2004; 1, 3, 7, 14, 28 days; Controls received mp w/ vehicle; animal info (Wistar, male, 240-260 g, 7 wks old; 5 wks old, DBH-Cre/Floxed-EGFP); functionality of mp verified by plasma NE levels.

Q0085 Knight,Z.A., Hannan,K.S., Greenberg,M.L., Friedman,J.M. Hyperleptinemia Is Required for the Development of Leptin Resistance. PLoS One 2010; 5(-6-):U248-U255. >>> Leptin, recomb.; PBS; SC; Mice; 1004; 2002; 2004; 20 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 4 weeks, or 12 days; animal info (male, ob/ob C57BL/6J, 4 wks old); functionality of mp verified by plasma leptin levels; "We found, consistent with previous studies, that leptin replacement in ob/ob animals is sufficient to normalize their body weight and other physiologic abnormalities, and furthermore that this normalization can be maintained for 6 months by replacing the pumps monthly." pg. e11377; obesity.

Q1181 Krahe,T.E., Medina,A.E. Activation of NMDA Receptors Is Necessary for the Recovery of Cortical Binocularity. Journal of Neurophysiology 2010; 103(-5-):2700-2706. >>> Phosphonopentanoic, D,L-2-amino,; Saline, sterile; CSF/CNS (visual cortex); Ferret; 1007D; 6 days; controls received mp w/ vehicle; animal info (PN 45-46); functionality of mp verified by residual volume; brain tissue distribution; good methods, pg 2701; "Cannulas were placed slightly rostral to area 17 to avoid mechanical damage to the recording site." pg 2701; fig 2A, image of cannula pedestal.

Q1030 la Santina,L., Bouly,M., Asta,A., Demontis,G.C., Cervetto,L., Gargini,C. Effect of HCN Channel Inhibition on Retinal Morphology and Function in Normal and Dystrophic Rodents. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2010; 51(-2-):1016-1023. >>> Ivabradine; Saline; SC; Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; animal info (adult, Long Evans); functionality of mp verified by residual volume; comparison of acute injections vs mp; "This instance is the first in which the effects of acute and long-term delivery of an HCN-inhibitor have been compared, showing that the consequences of the two different dosing approaches are similar and always reversible." pg 1022.

Q1572 Lai,Y.R., Sampson,K.E., Balogh,L.M., Brayman,T.G., Cox,S.R., Adams,W.J., Kumar,V., Stevens,J.C. Preclinical and Clinical Evidence for the Collaborative Transport and Renal Secretion of an Oxazolidinone Antibiotic by Organic Anion Transporter 3 (OAT3/SLC22A8) and Multidrug and Toxin Extrusion Protein 1 (MATE1/SLC47A1). Journal of Pharmacology and Experimental Therapeutics 2010; 334(-3-):936-944. >>> PNU-288034; Cyclodextrin, hydroxypropyl, beta-; SC; Mice; 2001D; 24 hours; animal info (wt, OAT3 -/-); 10% cyclodextrin used; PNU-288034 also known as N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide is oxazolidinone antibiotic; functionality of mp verified by plasma drug levels; 10% cyclodextrin used.

Q0498 Mazarati,A.M., Pineda,E., Shin,D., Tio,D., Taylor,A.N., Sankar,R. Comorbidity between epilepsy and depression: Role of hippocampal interleukin-1beta. NEUROBIOLOGY OF DISEASE 2010; 37(-2-):461-467. >>> Interleukin-1, receptor antagonist, human, recomb.; Saline, sterile; CSF/CNS (hippocampus); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit 1 used; multiple pumps per animal (2); animal info (male, Wistar, 50 days old); bilateral hippocampal infusion.

P9909 Morris,M.J., Na,E.S., Johnson,A.K. Mineralocorticoid Receptor Antagonism Prevents Hedonic Deficits Induced by a Chronic Sodium Appetite. Behavioral Neuroscience 2010; 124(-2-):211-224. >>> RU 28318; RU 486; CSF/CNS (intracranial); Rat; 2004; ; Animal info (male, Sprague Dawley, 250-375 g); silastic tubing used; "A better strategy may have been to chronically infuse CAP via osmotic pumps." pg 220; functionality of mp verified by residual volume.

Q0179 Oliveira,E., Pinheiro,C.R., Santos-Silva,A.P., Trevenzoli,I.H., breu-Villaca,Y., Neto,J.F.N., Reis,A.M., Passos,M.C.F., Moura,E.G., Lisboa,P.C. Nicotine exposure affects mother's and pup's nutritional, biochemical, and hormonal profiles during lactation in rats. Journal of Endocrinology 2010; 205(-2-):159-170. >>> Nicotine, free base; Saline, physiological; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (female, Wistar, 3 months old, lactating); functionality of mp verified by serum cotinine levels; endocrinology.

Q0026 Owens,AP III, Subramanian,V., Moorleghen,J.J., Guo,Z.H., McNamara,C.A., Cassis,L.A., Daugherty,A. Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3. Circulation Research 2010; 106(-3-):611-U108. >>> Angiotensin II; norepinephrine; losartan; Saline; Mice; 4 weeks; 28 days; Controls received mp w/vehicle; peptides; cardiovascular; animal info (male, C57BL/6, AT1aR -/-, p47phox -/-, Id3 -/-); functionality of mp verified by systolic blood pressure.

Q0027 Paglialunga,S., Fisette,A., Munkonda,M., Gao,Y., Richard,D., Cianflone,K. The effects of acylation stimulating protein supplementation VS antibody neutralization on energy expenditure in wildtype mice. BMC PHYSIOLOGY 2010; 10(-;-):U1-U11. >>> Antibody, anti- acylation stimulating protein; acylation stimulating protein, recomb. human; immunoglobulin G; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/IgG; peptides; animal info (male, C57BL/6, 7-8 weeks old); functionality of mp verified by residual volume.

Q0180 Pierce,A.A., Xu,A.W. De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance. Journal of Neuroscience 2010; 30(-2-):723-730. >>> Ara-C; uridine, 5' bromodeoxy; CSF, artificial; BSA; CSF/CNS; Mice (transgenic); 2006; 4, 6 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit; animal info (male, wt, AgRP-Tfam, 12 weeks old); functionality of mp verified by residual volume; cannula placement confirmed histologically.

Q0095 Schmidt,N.O., Ziu,M., Cargioli,T., Westphal,M., Giese,A., Black,P.M., Carroll,R.S. Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy. Translational Oncology 2010; 3(-1-):43-49. >>> Furegrelate; PBS; CSF/CNS (intratumoral); Mice (nude); 2004; 4 weeks; Controls received mp w/ vehicle; tissue perfusion (tumor); functionality of mp verified by residual volume; stress/adverse reaction: (see pg. 46) "hemosiderin deposits"; cancer (glioma); ALZET brain infusion kit used; animal info (Swiss, 4-6 wks old).

Q0186 Schopfer,F.J., Cole,M.P., Groeger,A.L., Chen,C.S., Khoo,N.K.H., Woodcock,S.R., Golin-Bisello,F., Motanya,U.N., Li,Y., Zhang,J.F., Garcia-Barrio,M.T., Rudolph,T.K., Rudolph,V., Bonacci,G., Baker,P.R.S., Xu,H.E., Batthyany,C.I., Chen,Y.E., Hallis,T.M., Freeman,B.A. Covalent Peroxisome Proliferator-activated Receptor-gamma Adduction by Nitro-fatty Acids SELECTIVE LIGAND ACTIVITY AND ANTI-DIABETIC SIGNALING ACTIONS. Journal of Biological Chemistry 2010; 285(-16-):12321-12333. >>> Oleic acid; rosiglitazone; oleic acid, nitro-; Mice; 28 days; Controls received mp w/ vehicle; no stress (pg. 12331); animal info (male, C57BL/6J, ob/ob, 8-10 weeks old); functionality of mp verified by plasma agent levels.

Q0056 Strait,K.R., Orkin,J.L., Anderson,D.C., Muly,E.C. Chronic, Constant-Rate, Gastric Drug Infusion in Nontethered Rhesus Macaques (Macaca mulatta). Journal of the American Association for Laboratory Animal Science 2010; 49(-2-):207-214. >>> Antipsychotic; Stomach (gastric lumen); Monkey; 2ML2; 2ML4; 12 months; Controls received mp w/ saline; no stress (see pg. 210); long-term infusion; animal info (male, Rhesus Macaques, 8.12 - 12.18 kg, 5.25 - 7.5 years old); post op. care (buprenorphine, meloxicam); functionality of mp verified by residual volume, plasma drug concentrations; pumps replaced every 2-4 weeks; good methods (pg. 208-210); mp placed SC with a gastric catheter to the stomach; concurrent gastroscopy used confirm catheter tip placement; catheter patency during the year was confirmed by endoscopy; cranial PET scans every 2-4 weeks; agent and saline were alternated during the 52 weeks, as were drug concentrations; "All 5 macaques tolerated placement of the gastric catheter and pump changes well. The animals maintained good condition throughout the course of the yearlong study" (pg. 210); "This method offers an attractive alternative for use in studies that require continuous, constant rate, enteral drug delivery in untethered monkeys. (pg. 214).

Q1335 Sun,D., Bullock,M.R., Altememi,N., Zhou,Z.W., Hagood,S., Rolfe,A., McGinn,M.J., Hamm,R., Colello,R.J. The Effect of Epidermal Growth Factor in the Injured Brain after Trauma in Rats. Journal of Neurotrauma 2010; 27(-5-):923-938. >>> Epidermal growth factor, recomb. human; CSF, artificial; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, 3-4 mo old, Sprague Dawley, 300 g); functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; artificial CSF recipe; cannula placement verified by injecting Evan's Blue dye into the cannula.

Q1362 Toledo,R.N., Borin,A., Cruz,O.L.M., Ho,P.L., Testa,J.R.G., Fukuda,Y. The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration. OTOLOGY&NEUROTOLOGY 2010; 31(-3-):498-505. >>> Fibroblast growth factor, basic; albumin, human; Ringer lactate solution; CSF/CNS (facial nerve anastomosis); Rat; 2002; 14 days; Controls received mp w/ sodium heparin, human albumin in Ringer lactate solution; animal info (male, Wistar, adult); functionality of mp verified by residual volume; good methods, pg 499; stress/adverse reaction: (see pg. 501) "neuroma at the anastomosis", "hemoatoma at the surgical incision"; tissue perfusion (epineural anastomosis); vinyl catheter used; "We chose to use minipumps because this method allows better control of the quantity of bFGF delivered at the target site and is compatible with standard facial nerve surgical techniques. Furthermore, the isolate reservoir of the minipumps prevents the contact of the study drug with substances that could inactivate it" pg 502.

Q1553 Verhovshek,T., Sengelaub,D.R. Trophic Effects of Brain-Derived Neurotrophic Factor Blockade in an Androgen-Sensitive Neuromuscular System. Endocrinology 2010; 151(-11-):5337-5348. >>> Immunoglobulin G, TrkB; PBS; BSA; SC; Rat; 2004; 3 weeks; Controls received mp w/ IgG1 Fc; animal info (Sprague Dawley, male, 100 days old); functionality of mp verified by residual volume.

Q0429 Wahl,D.R., Petersen,B., Warner,R., Richardson,B.C., Glick,G.D., Opipari,A.W. Characterization of the metabolic phenotype of chronically activated lymphocytes. LUPUS 2010; 19(-13-):1492-1501. >>> Glucose, C13 labeled; Water; SC; Mice; 2001D; 6 hours; Animal info (9 mo old, autoimmune, female, NZB/W, age matched BALB/c, female); functionality of mp verified by plasma glucose levels.

Q0192 Wahl,E.C., Aronson,J., Liu,L.C., Fowlkes,J.L., Thrailkill,K.M., Bunn,R.C., Skinner,R.A., Miller,M.J., Cockrell,G.E., Clark,L.M., Ou,Y., Isales,C.M., Badger,T.M., Ronis,M.J., Sims,J., Lumpkin,CK Jr  Journal of Bone and Mineral Research 2010; 25(-1-):114-123. >>> Tumor necrosis factor, recomb. mouse; PBS; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6 wt, p21 KO, 3 months old, distraction osteogenesis); functionality of mp verified by TNF serum levels.

Q1390 Ward,W.K., Hansen,J.C., Massoud,R.G., Engle,J.M., Takeno,M.M., Hauch,K.D. Controlled release of dexamethasone from subcutaneously-implanted biosensors in pigs: Localized anti-inflammatory benefit without systemic effects. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2010; 94A(-1-):280-287. >>> Dexamethasone; Cyclodextrin, 2-hydroxypropyl, beta; SC; Pig (mini); 2004; 2ML4; 28 days; Controls received mp w/ normal saline; animal info (Yucatan, adult, 60-70 kg); functionality of mp verified by opening and inspecting the pump; dose-response; multiple pumps per animal (2); Fig 1, image of biosensor array with ALZET pump.

Q1665 Watanabe,F., Kirkegaard,M., Matsumoto,S., Gont,C., Mannstroem,P., Ulfendahl,M., Fridberger,A. Signaling through erbB receptors is a critical functional regulator in the mature cochlea. European Journal of Neuroscience 2010; 32(-5-):717-724. >>> PD153035; 4557W; DMSO; artificial perilymph; Ear (cochlea); Guinea pig; 2002; ; Controls received mp w/ artificial perilymph; animal info (female, pigmented, 250-500 g); functionality of mp verified by residual volume; tissue perfusion (intracochlear); 0.1% DMSO used; enzyme inhibitor (tyrosine kinase).

Q1647 Yan,Y.J., Ouyang,J., Wang,C., Wu,Z., Ma,X., Li,H.Z., Xu,H., Hu,Z., Li,J., Wang,B.J., Shi,T.P., Gong,D.J., Ni,D., Zhang,X. Aortic Cell Apoptosis in Rat Primary Aldosteronism Model. Journal of Huazhong University of Science and Technology-Medical Sciences 2010; 30(-3-):385-390. >>> Aldosterone; Propylene glycol; ethanol; water,; SC; Rat; 2004; 8 weeks; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 7 wks old, 230-250 g); pumps replaced after 4 weeks; long-term study; functionality of mp verified by plasma aldosterone levels.

P9491 Adachi,M., Autry,A.E., Covington,HE III, Monteggia,L.M. MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome. Journal of Neuroscience 2009; 29(-13-):4218-4227. >>> Hydroxamic acid, suberoylanilide; Cyclodextrin; PBS; CSF/CNS (basolateral amygdala); Mice; 14 days; Controls received mp w/ vehicle; functionality of mp verified by examining the levels of acetylated histone H3 and H4; enzyme inhibitor (histone deacetylase); animal info (male, C57BL/6, 8 wks old); 5% cyclodextrin used; Plastics One bilateral cannula used; suberoylanilide hydroxamic acid also known as SAHA; behavioral testing (rotarod and locomotor activity, open-field test, elevated-plus maze, social interaction test; fear conditioning, pain sensitivity).

P9856 Adkesson,M.J., Citino,S.B., Dennis,P.M., Fiorello,C.V., Lafortune,M., Bennett,R.A. MEDICAL AND SURGICAL MANAGEMENT OF OTITIS IN CAPTIVE BONGO (TRAGELAPHUS EURYCERUS). JOURNAL OF ZOO AND WILDLIFE MEDICINE 2009; 40(-2-):332-343. >>> Amikacin; Ear; Antelope (bongo); 2ML4; 24 days; Functionality of mp verified by residual volume; animal info (10 years old, male, 326 kg); "An osmotic pump was beneficial for antibiotic delivery in case 2 and may be an effective therapy for low-grade infections or for continued therapy once a severe infection is under control." pg. 340.

P9799 Becklund,B.R., Hansen,DW Jr, DeLuca,H.F. Enhancement of 1,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis by calcitonin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-13-):5276-5281. >>> Calcitonin, salmon; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (Fig. 2); animal info (female, C57BL/6, 6 wks old).

Q0562 Bennett,S.P., Boyd,T.D., Norden,M., Padmanabhan,J., Neame,P., Wefes,I., Potter,H. A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease. Journal of Neuroscience Methods 2009; 184(-2-):320-326. >>> Antichymotrypsin, alpha-1; CSF, artificial; CSF/CNS; CSF/CNS (hippocampal parenchyma); Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (PS/APP, PS/APP/ACT, 10 mo old); functionality of mp verified by residual volume; cyanoacrylate adhesive; multiple pumps per animal (2); stability verified ("minimal degradation" after 28 days); custom catheter solution for simultaneous bilateral brain infusions; nitrile cap used to affix custom catheters to the skull; pump plus custom catheter assembly Fig 3e; "entire catheters and pumps we used can be completely removed without terminating the life of the animal" pg 326.

P9544 Bodell,P.W., Kodesh,E., Haddad,F., Zaldivar,F.P., Cooper,D.M., Adams,G.R. Skeletal muscle growth in young rats is inhibited by chronic exposure to IL-6 but preserved by concurrent voluntary endurance exercise. Journal of Applied Physiology 2009; 106(-2-):443-453. >>> Interleukin-6, recomb. rat; IM (gastrocnemius); Rat; 2002; 14 days; Controls received mp w/vehicle; functionality of mp verified by residual volume; animal info (Sprague Dawley, 5.5 wks old, 118g); fenestrated catheter used.

P9393 Bridges,J.P., Gilbert,J.S., Colson,D., Gilbert,S.A., Dukes,M.P., Ryan,M.J., Granger,J.P. Oxidative Stress Contributes to Soluble Fms-Like Tyrosine Kinase-1 Induced Vascular Dysfunction in Pregnant Rats. American Journal of Hypertension 2009; 22(-5-):564-568. >>> Flt-1, soluble; Saline, sterile; IP; Rat (pregnant); 2001; 5 days; Controls received mp w/ vehicle; functionality of mp verified by sFlt-1 plasma/serum concentrations; cardiovascular; animal info (female, Sprague Dawley, gd13).

P9753 Buckmaster,P.S., Ingram,E.A., Wen,X.L. Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy. Journal of Neuroscience 2009; 29(-25-):8259-8269. >>> Rapamycin; DMSO; ethanol; fluorescein; CSF/CNS (dentate gyrus); Rat; 2004; 1-2 months; Controls received mp w/vehicle; functionality of mp verified by fluorescein labeling; long-term study; pumps replaced after 1 month; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley, 34 days old); 50% DMSO used; 15% ethanol used.

Q0266 Byrnes,K.R., Stoica,B., Riccio,A., Pajoohesh-Ganji,A., Loane,D.J., Faden,A.I. Activation of Metabotropic Glutamate Receptor 5 Improves Recovery after Spinal Cord Injury in Rodents. Annals of Neurology 2009; 66(-1-):63-74. >>> Hydroxyphenylglycine, (RS)-2-chloro-5; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Sprague-Dawley, 275-325 g); functionality of mp verified by pump weight (not a valid method); spinal cord injury; 10% DMSO used; compound also known as CHPG; CHPG is a selective mGluR5 agonist.

Q0269 Cain,S.M., Ruest,T., Pimlott,S., Patterson,J., Duncan,R., Dewar,D., Sills,G.J. High resolution micro-SPECT scanning in rats using 125I beta-CIT: Effects of chronic treatment with carbamazepine. Epilepsia 2009; 50(-8-):1962-1970. >>> Carbamazepine; DMSO; propylene glycol; ethyl alcohol; acetone; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (adult, male, Sprague-Dawley, 160-270 g); functionality of mp verified by serum drug levels; 42% DMSO used; identified 3 mg/kg/day as the highest dose that could be reliably administered via minipumps over a 14-day period at 37 degrees Celsius, pg. 1969.

P9395 Carlstrom,M., Lai,E.Y., Ma,Z., Patzak,A., Brown,R.D., Persson,A.E.G. Role of NOX2 in the regulation of afferent arteriole responsiveness. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 296(-1-):R72-R79. >>> Angiotensin II; SC; Mice; 14 days; Functionality of mp verified by blood pressure; no stress (see pg. R73); cardiovascular; peptides; animal info (male, C57BL/6J, wt NOX2 -/-, 20-25 g.).

P9746 Catania,C., Sotiropoulos,I., Silva,R., Onofri,C., Breen,K.C., Sousa,N., Almeida,O.F.X. The amyloidogenic potential and behavioral correlates of stress. Molecular Psychiatry 2009; ;(-1-):95-105. >>> Amyloid protein, beta (1-40); Water, distilled; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/vehicle; functionality of mp verified; ALZET brain infusion kit used; peptides; animal info (male, Wistar, 14 months old); neurodegenerative (Alzheimer's disease); cannula patency verified.

Q0464 Chen,S.R., Samoriski,G., Pan,H.L. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology 2009; 57(-2-):121-126. >>> Neramexane mesylate; memantine; gabapentin; Saline, sterile; water; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; animal info (male, 225-250 g, STZ induced diabetes); functionality of mp verified by plasma drug levels; post op. care (penicillin); wound clips used; neuropathic pain.

Q0631 Coccurello,R., Brina,D., Caprioli,A., Conti,R., Ghirardi,O., Schepis,F., Moles,A. 30 Days of Continuous Olanzapine Infusion Determines Energy Imbalance, Glucose Intolerance, Insulin Resistance, and Dyslipidemia in Mice. Journal of Clinical Psychopharmacology 2009; 29(-6-):576-583. >>> Olanzapine; Acetic acid; saline, isotonic; sodium hydroxide; SC; Mice; 2004; 30 days; Controls received mp w/ vehicle; animal info (CD-1, 11 wks old, female); functionality of mp verified by residual volume; "Although (degradation of AAP agents in mini-pump reservoir over time) is a serious concern, significant increases of body weight and food intake were found in female rats33Y35 and mice14 under constant OL infusion via implanted mini-pumps" pg 582.

Q0038 Cooke,J.H., Patterson,M., Patel,S.R., Smith,K.L., Ghatei,M.A., Bloom,S.R., Murphy,K.G. Peripheral and Central Administration of Xenin and Neurotensin Suppress Food Intake in Rodents. Obesity 2009; 17(-6-):1135-1143. >>> Xenin; neurotensin; SC; Mice; 1007D; 6 days; Controls received mp w/ saline; peptides; no stress (pg 1142); animal info (male, C57BL/6); comparison of IP injections vs. SC mp; dose-response (table 1); functionality of mp verified by residual volume.

P9404 Doller,A., Gauer,S., Sobkowiak,E., Geiger,H., Pfeilschifter,J., Eberhardt,W. Angiotensin II Induces Renal Plasminogen Activator Inhibitor-1 and Cyclooxygenase-2 Expression Post-Transcriptionally via Activation of the mRNA-Stabilizing Factor Human-Antigen R. American Journal of Pathology 2009; 174(-4-):1252-1263. >>> Angiotensin II; Saline; SC; Rat; 2001; 7, 14 days; 6 hours; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 180-200 g.); nephrology.

Q0446 Flandin,P., Lehr,L., Asensio,C., Giacobino,J.P., Rohner-Jeanrenaud,F., Muzzin,P., Jimenez,M. Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism. Endocrine 2009; 36(-2-):246-254. >>> Triiodothyronine; NaCl; SC; Mice; 2001; 3 days; Controls received mp w/ vehicle; animal info (WT, UCP3KO, 2 mo old, female); functionality of mp verified by "increase in T3 during the treatment".

Q0367 Fuller,D.D., Dougherty,B.J., Sandhu,M.S., Doperalski,N.J., Reynolds,C.R., Hayward,L.F. Prenatal nicotine exposure alters respiratory long-term facilitation in neonatal rats. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2009; 169(-3-):333-337. >>> Nicotine; SC; Rat (pregnant); 2ML4; 1, 2 weeks; Controls received mp w/ saline; animal info (Sprague-Dawley, female); functionality of mp verified by plasma nicotine levels; post op. care (buprenorphine, carprofen); wound clips used.

Q0265 Gadjanski,I., Boretius,S., Williams,S.K., Lingor,P., Knoeferle,J., Saettler,M.B., Fairless,R., Hochmeister,S., Suehs,K.W., Michaelis,T., Frahm,J., Storch,M.K., Baehr,M., Diem,R. Role of N-Type Voltage-Dependent Calcium Channels in Autoimmune Optic Neuritis. Annals of Neurology 2009; 66(-1-):81-93. >>> Conotoxin, w-; CSF, artificial; CSF/CNS; Rat; 2004; 8, 23 days; Controls received mp w/ vehicle; animal info (female brown Norway, 8-10 wks old); functionality of mp verified by residual volume; w-conotixin is an N-type specific blocker.

P9483 Galeote,L., Berrendero,F., Bura,S.A., Zimmer,A., Maldonado,R. Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 2009; 12(-5-):615-625. >>> Nicotine hydrogen tartrate salt; SC; Mice; 2001; 6 days; Controls received mp w/ saline; functionality of mp verified by residual volume; dependence; animal info (male, C57BL/6, wt, prodynorphin KO) dose (~ 25 mg/kg/d).

Q0603 Gallego,J.M., Ortiz,L., Gutierrez,R., Barcia,J.A. Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 2009; 18(-7-):537-540. >>> Aminobutyric acid, gamma; Saline; CSF/CNS (dorsomedian nuclei of the thalamus); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Wistar); functionality of mp verified by residual volume; multiple pumps per animal (2); bilateral infusion.

P9407 Giachini,F.R.C., Zemse,S.M., Carneiro,F.S., Lima,V.V., Carneiro,Z.N., Callera,G.E., Ergul,A., Webb,R.C., Tostes,R.C. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-2-):H489-H496. >>> Tumor necrosis factor-a; Saline; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by serum TNFa levels; cardiovascular; animal info (male, C57BL/6, wt, IL-1D -/-, 10 wks old).

P9410 Hasegawa,T., Iwanaga,K., Hultquist,D.E., Liao,H., Visovatti,S.H., Pinsky,D.J. Suppression of nitrosative and oxidative stress to reduce cardiac allograft vasculopathy. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-4-):H1007-H1016. >>> Riboflavin; Saline; IP; Mice; 1003D; 3 days; Controls received mp w/ vehicle; functionality of mp verified by plasma riboflavin levels; dose-response (fig. 1); cardiovascular; immunology; animal info (male, CBA/J, B1OA, 8-12 wks old, cardiac transplantation); antioxidant.

Q0951 Hashimoto,M., Hossain,S., Tanabe,Y., Kawashima,A., Harada,T., Yano,T., Mizuguchi,K., Shido,O. The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40). JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2009; 20(-12-):965-973. >>> Amyloid protein, beta (1-40); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (Wistar, 5 wks old); functionality of mp and cannula placement verified by examining brain slices; neurodegenerative (Alzheimer's disease).

P9869 Herrmann,M., Henneicke,H., Street,J., Modzelewski,J., Kalak,R., Buttgereit,F., Dunstan,C.R., Zhou,H., Seibel,M.J. The challenge of continuous exogenous glucocorticoid administration in mice. Steroids 2009; 74(-2-):245-249. >>> Corticosterone; PEG 400; DMSO; SC; Mice; 2004; 21 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; comparison of SC injections vs. pellet vs SC mp; animal info (Swiss White, male, CD1. 7-9 wks old).

Q0545 Hicks,A.U., Lappalainen,R.S., Narkilahti,S., Suuronen,R., Corbett,D., Sivenius,J., Hovatta,O., Jolkkonen,J. Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery. European Journal of Neuroscience 2009; 29(-3-):562-574. >>> Cyclosporine A; PEG 400; SC; Rat; 2ML4; 2002; ; Controls received mp w/ vehicle; animal info (male, Wistar, 275-300 g, dMCAO); functionality of mp verified by residual volume; behavioral testing (Montoya's staircase test).

Q0827 Huang,L.H., Haylor,J.L., Hau,Z., Jones,R.A., Vickers,M.E., Wagner,B., Griffin,M., Saint,R.E., Coutts,I.G.C., El Nahas,A.M., Johnson,T.S. Transglutaminase inhibition ameliorates experimental diabetic nephropathy. Kidney International 2009; 76(-4-):383-394. >>> NTU281, dansyl labeled; PBS; Intrarenal; Rat; 2ML4; 1, 4, 8 months; Controls received mp w/ vehicle; animal info (male, Wistar, Han, uninephrectomized); functionality of mp verified by residual volume, Fig 2a; long-term study; pumps replaced every 28 days; enzyme inhibitor (transglutaminase); "cannula was secured using silk ties and tissue glue and run through the muscle wall to the pump located on the scruff" pg 392.

Q0590 Ingram,E.A., Toyoda,I., Wen,X.L., Buckmaster,P.S. Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy. Epilepsia 2009; 50(-1-):56-64. >>> Nicardipine; FK-506; cyclosporin A; DMSO; ethanol; fluorescein; CSF/CNS (dorsal left dentate gyrus); Rat; 2004; 28 days; Controls were treated identically without status epilepticus; animal info (34-52 day old, male, Sprague-Dawley, status epilepticus); functionality of mp verified by fluorescein labeling; ALZET brain infusion kit 2 used; 50% DMSO used; 15% ethanol used.

P9416 Isa,K., Garcia-Espinosa,M.A., Arnold,A.C., Pirro,N.T., Tommasi,E.N., Ganten,D., Chappell,M.C., Ferrario,C.M., Diz,D.I. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2) 27 hypertensive rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 297(-1-):R111-R115. >>> Antibody, rabbit anti-rat ANG (1-12); immunoglobulin G, rabbit; CSF, artificial; CSF/CNS; Rat (transgenic); 2ML2; 14 days; Controls received mp w/ IgG; functionality of mp verified by residual volume; no stress (see pg. R111, R112); stability verified by activity of agent in residual volume, 91-98% on day 13; antihypertensive; ALZET brain infusion 2 kit; animal info (male, (mRen2)27 Tg, 22-28 wks old, 550g.); cannula placement confirmed at end of each study.

P9790 Joosen,M.J.A., Jousma,E., van den Boom,T.M., Kuijpers,W.C., Smit,A.B., Lucassen,P.J., Van Helden,H.P.M. Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology 2009; 30(-1-):72-80. >>> Olanzapine; Acetic acid, glacial; SC; Rat; 2ML4; 4 weeks; Functionality of mp verified by residual volume; animal info (male, Sprague Dawley); stability verified for 4 weeks by electrospray MS/MS.

P9786 Kanemaru,K., Nishi,K., Hasegawa,S., Diksic,M. Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats. NEUROCHEMISTRY INTERNATIONAL 2009; 54(-5-6-):363-371. >>> Citalopram hydrobromide; Saline; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; animal info (male, Sprague Dawley, 200 g.).

Q0613 Kawasaki,M., Ponzio,T.A., Yue,C.M., Fields,R.L., Gainer,H. Neurotransmitter regulation of c-fos and vasopressin gene expression in the rat supraoptic nucleus. Experimental Neurology 2009; 219(-1-):212-222. >>> TTX; CNQX; APV; Saline; CSF/CNS (supraoptic nucleus); Rat; 2001D; 3.5 hours; Controls received mp w/ vehicle; animal info (adult, male, Spraque-Dawley, 250-350 g); functionality of mp verified by measuring Fluorogold in the brain; multiple pumps per animal (2); multiple cannulae (2, 28 gauge) used; pumps not implanted but activated by immersion in 0.9% saline at 37°C.; PE-60 tubing used.

Q0588 Keiner,S., Witte,O.W., Redecker,C. Immunocytochemical Detection of Newly Generated Neurons in the Perilesional Area of Cortical Infarcts After Intraventricular Application of Brain-Derived Neurotrophic Factor. Journal of Neuropathology and Experimental Neurology 2009; 68(-1-):83-93. >>> Brain-derived neurotrophic factor; NaCl; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (male, Wistar, 12-14 weeks, 250-300 g); functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; ischemia (focal cortical infarct); behavioral testing (the limb-use asymmetry; tapered beam walking; ladder rung walking); fig. 1c diagram of a parasagittal section of the rat brain showing cannula placement.

P9774 Khan,N., Mupparaju,S.P., Hou,H., Lariviere,J.P., Demidenko,E., Swartz,H., Eastman,A. Radiotherapy in Conjunction with 7-Hydroxystaurosporine: A Multimodal Approach with Tumor pO2 as a Potential Marker of Therapeutic Response. RADIATION RESEARCH 2009; 172(--):592-597. >>> UCN-01; Sodium acetate; SC; Mice; 1003D; 3 days; Functionality of mp verified by plasma UCN-01 concentrations; cancer (radiation therapy); animal info (female, C3H/HEJ, 18-20 g.).

Q0775 Khasar,S.G., Dina,O.A., Green,P.G., Levine,J.D. Sound Stress-Induced Long-Term Enhancement of Mechanical Hyperalgesia in Rats Is Maintained by Sympathoadrenal Catecholamines. JOURNAL OF PAIN 2009; 10(-10-):1073-1077. >>> Epinephrine; SC; Rat; 2004; 14 days; Animal info (adrenal medullectomy, adult, male, Sprague Dawley, 300-400 g); functionality of mp verified by plasma drug levels.

Q0439 Lubel,J.S., Herath,C.B., Tchongue,J., Grace,J., Jia,Z.Y., Spencer,K., Casley,D., Crowley,P., Sievert,W., Burrell,L.M., Angus,P.W. Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Clinical Science 2009; 117(-11-12-):375-386. >>> Angiotensin (1-7); Saline; IP; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 6 wks old, male); functionality of mp verified by residual volume; peptides.

P9613 Ma,T., Ortiz,S.G., Huang,Z.N., Ren,P.G., Smith,R.L., Goodman,S.B. In Vivo Murine Model of Continuous Intramedullary Infusion of Particles-A Preliminary Study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2009; 88B(-1-):250-253. >>> Polystyrene particles, blue dyed; PBS; Bone (femur); Mice; 2004; 4 weeks; Functionality of mp verified by gross inspection of retrieved femora; animal info (9 wks old, male, C57BL/6); Fig. 1, X-ray image of pump and delivery system; tissue perfusion (femur).

P9857 Magge,S.N., Malik,S.Z., Royo,N.C., Chen,H.I., Yu,L., Snyder,E.Y., O'Rourke,D.M., Watson,D.J. Role of Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) in Migration of Neural Progenitor Cells Toward Glial Tumors. Journal of Neuroscience Research 2009; 87(-7-):1547-1555. >>> MCP-1, recomb. rat; PBS; BSA; CSF/CNS (corpus callosum); Rat; 1007D; 7 days; Controls received MCP-1 w/o transplant or transplant w/o MCP-1; functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; animal info (adult, Fischer, female, 150-200 g.); brain tissue distribution.

Q0687 Molina-Luna,K., Pekanovic,A., Roehrich,S., Hertler,B., Schubring-Giese,M., Rioult-Pedotti,M.S., Luft,A.R. Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity. PLoS One 2009; 4(-9-):U127-U136. >>> Levodopa; NaCl; CSF/CNS (primary motor cortex); Rat; ; Controls received mp w/ vehicle; animal info (adult, male, Long-Evans, 332.1 g, ); functionality of mp verified by Nissl staining histology; tissue perfusion (motor cortex).

Q0701 Mouret,A., Lepousez,G., Gras,J., Gabellec,M.M., Lledo,P.M. Turnover of Newborn Olfactory Bulb Neurons Optimizes Olfaction. Journal of Neuroscience 2009; 29(-39-):12302-12314. >>> zVAD; Saline; DMSO; CSF/CNS (olfactory bulb); Mice; 1002; 15 days; Controls received mp w/ vehicle; animal info (2 mo old, male, C57BL/6J); peptides; functionality of mp verified by pump weight (not a valid method); ALZET brain infusion kit 3 used; 1.5% DMSO used; Chicago blue dye used to verify cannula placement.

Q0456 Naghshin,J., McGaffin,K.R., Witham,W.G., Mathier,M.A., Romano,L.C., Smith,S.H., Janczewski,A.M., Kirk,J.A., Shroff,S.G., O'Donnell,C.P. Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice. Journal of Applied Physiology 2009; 107(-3-):787-793. >>> Propranolol; SC; Mice; 4 weeks; Animal info (male, C57BL/6J, 20-25 g, 9-12 wk old); functionality of mp verified by heart rate.

Q0282 Schmidt,C., Bezuidenhout,D., Beck,M., Van der Merwe,E., Zilla,P., Davies,N. Rapid three-dimensional quantification of VEGF-induced scaffold neovascularisation by microcomputed tomography. Biomaterials 2009; 30(-30-):5959-5968. >>> Vascular endothelial growth factor (165); SC; Rat; 1002; 10 days; Controls received mp w/ PBS; animal info (male, Wistar, 234-254 g); functionality of mp verified by residual volume; post op. care (buprenorphine); pump connected to a porous polyurethane construct, schematic on Figure 1A;.

P9444 Shao,W.J., Seth,D.M., Navar,L.G. Augmentation of endogenous intrarenal angiotensin II levels in Val5-ANG II-infused rats. American Journal of Physiology-Renal Physiology 2009; 296(-5-):F1067-F1071. >>> Angiotensin II, val5-; angiotensin II, Ile5; SC; Rat; 2002; 13 days; Controls received sham operation; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague Dawley, 240-270 g.); nephrology.

P9852 Simcock,J.W., Penington,A.J., Morrison,W.A., Thompson,E.W., Mitchell,G.M. Endothelial Precursor Cells Home to a Vascularized Tissue Engineering Chamber by Application of the Angiogenic Chemokine CXCL12. Tissue Engineering Part A 2009; 15(-3-):655-664. >>> CXCL12; stromal cell-derived factor-1a, recomb. human; BSA; IV (arteriorvenous loop); Rat (nude); 1007D; 7 days; Functionality of mp verified; animal info (CBH/R nu/nu, 200-250 g.); diagram illustrating relationship of pump to chamber construct, fig. 1.

Q0264 Sykes,J.M., Cox,S., Ramsay,E.C. Evaluation of an osmotic pump for fentanyl administration in cats as a model for nondomestic felids. American Journal of Veterinary Research 2009; 70(-8-):950-955. >>> Fentanyl; Saline, sterile; SC; Cat (felid); 2ML1; 96 hours; Animal info (spayed, female, 56 months old, 4.5 kg); functionality of mp verified by residual volume; comparison of transdermal patch vs. SC mp; no stress see pg 952; "if fentanyl is "to be used for nondomestic cats, then the faster elimination of fentanyl after removal of a delivery device is an important advantage of the osmotic pump versus the transdermal patch" pg 953; "Compared with a transdermal patch, an osmotic pump provides several pharmacokinetic advantages for fentanyl administration in cats." pg 954.

Q0083 Tang,G.B., Cui,J.G., Wang,D.H. Role of hypoleptinemia during cold adaptation in Brandt's voles (Lasiopodomys brandtii). American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 297(-5-):R1293-R1301. >>> Leptin, recomb. murine; PBS; SC; Prairie vole; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Brandts, 90-120 days old); functionality of mp verified by serum leptin levels.

P9867 Thakker,D.R., Weatherspoon,M.R., Harrison,J., Keene,T.E., Lane,D.S., Kaemmerer,W.F., Stewart,G.R., Shafer,L.L. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-11-):4501-4506. >>> Immunoglobulin G1; 6E10; CSF/CNS; Mice; 2004; ; Functionality of mp verified in vitro for 5 weeks; stability verified in vitro for 5 weeks; animal info (male, 16-18 months old, Tg2576); neurodegenerative (Alzheimer's Disease); 6E10 is a mouse monoclonal IgG1; brain tissue distribution.

P9709 Thompson,E.L., Amber,V., Stamp,G.W.H., Patterson,M., Curtis,A.E., Cooke,J.H., Appleby,G.F., Dhillo,W.S., Ghatei,M.A., Bloom,S.R., Murphy,K.G. Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. British Journal of Pharmacology 2009; 156(-4-):609-625. >>> Kisspeptin-54; Saline; SC; CSF/CNS; Rat; 2001D; 2001; 1, 2, 3 days; 6, 12, 24 hours; Controls received mp w/vehicle; functionality of mp verified; peptides; animal info (adult, male, Wistar, 275-325 g.).

Q0767 Traub,M.L., De Butte-Smith,M., Zukin,R.S., Etgen,A.M. Oestradiol and Insulin-Like Growth Factor-1 Reduce Cell Loss after Global Ischaemia in Middle-Aged Female Rats. Journal of Neuroendocrinology 2009; 21(-12-):1038-1044. >>> Insulin-like growth factor-I; Saline, sterile; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 9-11 mo old, adult, 300-500 g); functionality of mp verified by residual volume; ALZET brain infusion kit used; cannula placement verified by inspection of cryostat sectioning; neuroprotection.

Q0659 Tsai,Y.J., Lin,C.T., Huang,C.T., Wang,H.Y., Tien,L.T., Chen,S.H., Lue,J.H. Neuropeptide Y Modulates c-Fos Protein Expression in the Cuneate Nucleus and Contributes to Mechanical Hypersensitivity following Rat Median Nerve Injury. Journal of Neurotrauma 2009; 26(-9-):1609-1621. >>> Neuropeptide Y, neuropeptide y antagonist; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 180-250 g); functionality of mp verified by residual volume; peptides.

P9868 Virk,M.S., Arttamangkul,S., Birdsong,W.T., Williams,J.T. Buprenorphine Is a Weak Partial Agonist That Inhibits Opioid Receptor Desensitization. Journal of Neuroscience 2009; 29(-22-):7341-7348. >>> Buprenorphine; DMSO; water; Rat; 2ML1; ; Controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; animal info (male, Sprague Dawley, 150-200 g.); 40% DMSO used; "the osmotic minipump delivered buprenorphine efficiently and predictably" pg. 7342.

Q0747 Wang,W.F., Baghdoyan,H.A., Lydic,R. Leptin Replacement Restores Supraspinal Cholinergic Antinociception in Leptin-Deficient Obese Mice. JOURNAL OF PAIN 2009; 10(-8-):836-843. >>> Leptin; Mice; 1007D; 7 days; Animal info (adult, male, B6, obese); functionality of mp verified by leptin ELISA kit; obesity.

P9460 Wells,S.M., Buford,M.C., Migliaccio,C.T., Holian,A. Elevated Asymmetric Dimethylarginine Alters Lung Function and Induces Collagen Deposition in Mice. American Journal of Respiratory Cell and Molecular Biology 2009; 40(-2-):179-188. >>> Arginine, asymmetric dimethyl-; SC; Mice; 2 weeks; Controls received mp w/ saline; functionality of mp verified by serum ADMA levels; dose-response (table 1); enzyme inhibitor (nitric oxide synthase); animal info (Balb/c); pulmonology.

P9659 Wilson-Gerwing,T.D., Johnston,J.M., Verge,V.M.K. p75 Neurotrophin Receptor Is Implicated in the Ability of Neurotrophin-3 to Negatively Modulate Activated ERK1/2 Signaling in TrkA-Expressing Adult Sensory Neurons. Journal of Comparative Neurology 2009; 516(-1-):49-58. >>> Neurotrophin 3; oligonucleotides, antisense; oligonucleotides, sense; PBS; Streptomycin; albumin, rat serum; penicillin; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/vehicle; functionality of mp verified by flurorescence; antisense (P75); animal info (young male, wistar, 250-300.

P9516 Wissman,A.M., Brenowitz,E.A. The Role of Neurotrophins in the Seasonal-Like Growth of the Avian Song Control System. Journal of Neuroscience 2009; 29(-20-):6461-6471. >>> TrkB-Fc; TrkC-Fc; brain-derived neurotrophic factor; nerve growth factor; PBS; CSF/CNS (robust nucleus of the arcopallium); Bird; 1002; ; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; animal info (sparrow, adult, male, Gambel's white crowned).

Q0619 Witzenrath,M., Gutbier,B., Schmeck,B., Tenor,H., Seybold,J., Kuelzer,R., Grentzmann,G., Hatzelmann,A., van Laak,V., Tschernig,T., Mitchell,T.J., Schudt,C., Rosseau,S., Suttorp,N., Schuette,H. Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Critical Care Medicine 2009; 37(-2-):584-590. >>> PDP, hydroxy; SC; Mice; 2001; ; Controls received mp w/ vehicle; animal info (female, Balb/C, C57Bl/6, 8-12 wks old); functionality of mp verified by plasma drug levels; enzyme inhibitor (phosphodiesterase-2); PDP also known as 9-(6-phenyl-2-oxohex-3-yl)-2-(3,4-dimethoxybenzyl)- purin-6one; "PDE2 inhibition by continuous infusion of hydroxy-PDP was capable of extensively reducing microvascular leakage in pneumonic mice without altering PDE2 mRNA expression. " pg 589.

P9577 Wright,J.W., Meighan,P.C., Brown,T.E., Wiediger,R.V., Sorg,B.A., Harding,J.W. Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3. Behavioural Brain Research 2009; 203(-1-):27-34. >>> MMP-3i; CSF/CNS; Rat; 2001; 6 days; Controls received mp aCSF; functionality of mp verified by residual volume; animal info (male, Sprague Dawley, 300-350g); behavioral testing (head-shake response habituation); cannula placement verified w/icv injection of fast green dye; enzyme inhibitor (metalloproteinase-3).

P9470 Ying,Z.K., Yue,P.B., Xu,X.H., Zhong,M.H., Sun,Q.H., Mikolaj,M., Wang,A.X., Brook,R.D., Chen,L.C., Rajagopalan,S. Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-5-):H1540-H1550. >>> Angiotensin II; Saline; acetic acid; SC; Mice; 14 days; Controls received mp w/ vehicle; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, C57BL/6, 8 wks old); pulmonology.

P9968 Zhang,Q., Yao,F.R., O'Rourke,S.T., Qian,S.Y., Sun,C.W. Angiotensin II enhances GABAB receptor-mediated responses and expression in nucleus tractus solitarii of rats. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-5-):H1837-H1844. >>> Angiotensin II; CSF/CNS; Rat; 2004; 7 days; Controls received mp w/ aCSF; peptides; cardiovascular; ALZET brain infusion kit 2 used; animal info (male, Sprague-Dawley, 290-350 g); functionality of mp verified by mean arterial BP.

P9767 Zhang,Q., Chen,C., Lue,J.G., Xie,M.J., Pan,D.J., Luo,X., Yu,Z.Y., Dong,Q., Wang,W. Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1-beta, MIP-1-alpha, and NO After Focal Cerebral Ischemia in the Rat. Glia 2009; 57(-8-):908-920. >>> Roscovitine; DMSO; saline; CSF/CNS; Rat; 2001; ; Controls received mp w/vehicle; functionality of mp verified by "weighing the cassette before placement and after the experiment" pg. 909; enzyme inhibitor (cyclin dependant kinase); ALZET brain infusion kit used; ischemia (cerebral); animal info (adult, male, Sprague Dawley, 220-270 g); 0.2% DMSO used; MCAO.

P9574 Zhao,R., Raub,T.J., Sawada,G.A., Kasper,S.C., Bacon,J.A., Bridges,A.S., Pollack,G.M. Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier. Drug Metabolism and Disposition 2009; 37(-6-):1251-1258. >>> Cimetidine; alfuzosin; dipyridamole; DMSO; SC; Mice; 2001D; 24 hours; Functionality of mp verified by residual volume; cancer (breast); animal info (Mdrla KO, wt, abcg2 -/-); 50%, 80% DMSO used; "(with dipyridamole in 80% DMSO)" precipitation was visible around the exit hole at the end of the experiment" pg. 1255.

 

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What researchers are saying...

“We switched to a 21-day minipumps paradigm using a dose that mimics serum antidepressant concentrations in humans because this regimen resulted in a more consistent and robust decrease in serotonin transporter levels in rats than what is observed with daily injections of serotonin reuptake inhibitors.” Weinshenker et al. 2002 Brain Research 946:239-246.