References on the Administration of Y-Aminobutyric Acid Using ALZET^® Osmotic Pumps

Q0603 Gallego,J.M., Ortiz,L., Gutierrez,R., Barcia,J.A. Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 2009; 18(-7-):537-540. >>> Aminobutyric acid, gamma; Saline; CSF/CNS (dorsomedian nuclei of the thalamus); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Wistar); functionality of mp verified by residual volume; multiple pumps per animal (2); bilateral infusion.

P8692 Navarro,V., Le Van Quyen,M., Martinerie,J., Rudrauf,D., Baulac,M., Menini,C. Loss of phase synchrony in an animal model of partial status epilepticus. Neuroscience 2007; 148(-1-):304-313. >>> Aminobutyric acid, gamma; Kreb's solution; CSF/CNS (left somatomotor cortex); Rat; 2001; 5 days; Controls received mp w/ vehicle; animal info (male, Wistar, 170-190g); epilepsy.

P7735 Silva-Barrat,C., Velluti,J., Szente,M., Batini,C., Champagnat,J. Exaggeration of epileptic-like patterns by nicotine receptor activation during the GABA withdrawal syndrome. Brain Research 2005; 1042(-2-):133-143. >>> Aminobutyric acid, gamma; CSF/CNS (somatomotor cortex); Rat; 2001; 5 days; Controls received mp w/ saline or no treatment; dependence; animal info (male, wistar).

P6975 Ding,R., Tsunekawa,N., Obata,K. Cleft palate by picrotoxin or 3-MP and palatal shelf elevation in GABA-deficient mice. NEUROTOXICOLOGY AND TERATOLOGY 2004; 26(-4-):587-592. >>> Picrotoxin; aminobutyric acid, Y; mercaptopropionic acid, 3-; SC; Mice (pregnant); 1003D; 3 days; Controls received mp w/ saline; comparison of SC injections vs. mp; no stress (see pg. 589); teratology; SC injections induced seizures, during mp infusion mice behaved normally.

P6456 Barcia,J.A., Castillo,A., Gutierrez,R., Gallego,J.M., Ortiz,L., Hernandez,M.E. Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat. Epilepsy Research 2004; 58(-1-):19-26. >>> Aminobutyric acid, Y-; mannitol; Saline; CSF/CNS (amygdala); Rat; 2001; 7 days; Controls received mp w/mannitol; functionality of mp verified by cutting open&visual inspection; dose-response (table 1); no stress (see pg. 25).

P4853 Yang,L., Long,C., Faingold,C.L. Audiogenic seizure susceptibility is induced by termination of continuous infusion of gamma-aminobutyric acid or an N-methyl-D-aspartic acid antagonist into the inferior colliculus. Experimental Neurology 2001; 171(--):147-152. >>> Aminobutyric acid, Y-; AP7; Saline; CSF/CNS (inferior collicus); rat; 1002; 7 days; controls received mp w/ vehicle; AP7 is an NMDA receptor antagonist; seizures; bilateral cannula used; 1 week recovery period from surgery; cannula placement verified at end of experiment by histology.

P3309 Shuaib,A., Ijaz,S., Hasan,S., Kalra,J. Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia. Brain Research 1992; 590(--):13-17. >>> GABA, gamma-vinyl-; Aminobutyric acid, Y-; CSF/CNS (third ventricle); gerbil; 5 days; Ischemia (cerebral).

P2959 Ballough,G., Majchrzak,M., Strauss,J., Kan,R., Anthony,A., Will,B. Cytophotometric analysis of magnocellular azure B-RNA and Feulgen-DNA following chronic GABA infusion into the nucleus basalis of rats. Life Sci. 1992; 50(-18-):1299-1310. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (nucleus basalis magnocellularis); rat; 2001; 24 hours; controls received mp with saline and/or were sham operated; protective cranial cap placed over cannula provided mechanical support and protection; animals allowed 1 week recovery before pump implantation; non-infused hemisphere of each animal served as control for the infused hemisphere.

P2152 Brailowsky,S., Montiel,T., Hernandez-Echeagaray,E., Flores-Hernandez,J., Hernandez-Pineda,R. Effects of a Ginkgo biloba extract on two models of cortical hemiplegia in rats. Restor.Neurol.Neurosci. 1991; 3(--):267-274. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (motor cortex); rat; 2001; 7 days; GABA withdrawal syndrome induced by infusion interruption achieved by disconnecting catheter leading to brain cannula after 24 hours.

P1465 Brailowsky,S., Silva-Barrat,C., Menini,C., Riche,D., Naquet,R. Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio. Electroencephalogr.Clin.Neurophysiol. 1989; 72(--):147-156. >>> Aminobutyric acid, Y-; Saline; CSF/CNS; Monkey (baboon); 2ML1; 7 days; functionality of mp verified by removing and opening; pumps replaced once w/ saline-filled mp.

P1397 La Salle,G., Brailowsky,S., Menini,C., Naquet,R. Local asymptomatic status epilepticus induced by withdrawal of GABA infusion into limbic structures. Exp.Neurol. 1988; 101(--):411-417. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; 6 days; mp connected to cannula; mp malfunction (pump disconnected after 6 days).

P1314 Brailowsky,S., Kunimoto,M., Menini,C., Silva-Barrat,C., Riche,D., Naquet,R. The GABA-withdrawal syndrome: a new model of focal epileptogenesis. Brain Research 1988; 442(--):175-179. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (cortex); rat; 2001; 3, 5, 7, 14 days and 3, 6, 12, 24 hours; pump replaced once at 7 days; long-term study.

P1297 Will,B.E., Toniolo,G., Brailowsky,S. Unilateral infusion of GABA and saline into the nucleus basalis of rats: 1. effects on motor function and brain morphology. Behav.Brain Research 1988; 27(--):123-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (nucleus basalis); rat; 2001; 4, 10 days; pumps exchanged with control pumps containing saline; comparison of icv injections vs. mp infusion; pump replaced at 4 days.

P1220 Brailowsky,S., Knight,R.T. Recovery from GABA-mediated hemiplegia in young and aged rats: effects of Catecholaminergic manipulations. Neurobiol.Aging 1987; 8(--):441-447. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (cortex); rat; 2001; 7 days; controls received mp w/ saline; mp connected to cannula in cortex.

P1152 Fukuda,H., Brailowsky,S., Menini,C., Silva-Barrat,C., Riche,D., Naquet,R. Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal. Exp.Neurol. 1987; 98(--):120-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; 7 days; controls received mp w/ saline; mp connected to bilateral cannulae; functionality of mp verified.

P1023 Brailowsky,S., Menini,C., Silva-Barrat,C., Naquet,R. Epileptogenic y-aminobutyric acid-withdrawal syndrome after chronic, intracortical infusion in baboons. Neurosci.Lett. 1987; 74(--):75-80. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (frontal cortex); Monkey (baboon); 2ML1; no duration posted; controls received mp w/vehicle; mp connected to intracerebral cannula; agent filled mp replaced after 7 days with saline filled mp; tissue perfusion (frontal cortex).

P0886 Loscher,W. Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacol.Biochem.Behav. 1986; 24(--):1007-1013. >>> Aminobutyric acid, Y-acetylenic Y-; Aminooxyacetic acid; Diazepam; THIP; Valproic acid; Saline; SC; rat; 2ML2; 2 weeks; controls received mp w/saline; diazepam too unstable to be used in mp; epilepsy; functionality of mp verified after 14 day exper. period - all 50 mps worked accurately; stability of VPA, THIP, GAG and AOAA.

P0877 Brailowsky,S., Knight,R.T., Efron,R. Phenytoin increases the severity of cortical hemiplegia in rats. Brain Research 1986; 376(--):71-77. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (somatomotor region); rat; 2001; 7 days; controls rec'd mp w/saline; mp connected to cannula in somatomotor region; mps may have become detached from cannula during study (see p.73).

P0787 Brailowsky,S., Knight,R.T., Blood,K., Scabini,D. g-Aminobutyric acid-induced potentiation of cortical hemiplegia. Brain Research 1986; 362(-2-):322-330. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (somatomotor region); rat; 2001; 7 days; controls received mp w/saline; mp connected to cannula in somatomotor area; functionality verified by completeness of delivery.

P0666 Beart,P.M., Scatton,B., Lloyd,K.G. Subchronic administration of GABAergic agonists elevates (3H)GABA binding and produces tolerance in striatal dopamine catabolism. Brain Research 1985; 335(-1-):169-173. >>> Aminobutyric acid, Y-acetylenic Y-; Aminobutyric acid, Y-vinyl Y-; Kojic amine; Aminooxyacetic acid; Baclofen; THIP; Water; SC; rat; 2001; 2002; 7-14 days; comparison of injec vs. mp infusion; comparison of agents effects; THIP is 4,5,6,7-tetrahydroisoxazolol (5,4-c) pyridin-3-ol; Kojic amine is 2-amino-methyl-5-hydroxy-4H-pyran-4-one.

P0439 Costall,B., Domeney,A.M., Naylor,R.J. Locomotor hyperactivity caused by dopamine infusion into the nucleus accumbens of rat brain: specificity of action. Psychopharmacology 1984; 82(--):174-180. >>> Acetylcholine HCl; Aminobutyric acid, Y-; Serotonin bimaleinate; Dopamine HCl; Norepinephrine bitartrate; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; 13 days; Cholinergic agent; comparison of agents effects; no stress p. 175; stability of substances remaining in pump after 13 days was verified.

P0289 Mangano,R.M., Schwarcz,R. Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus. Brain Res.Bull. 1983; 10(--):47-51. >>> Aminobutyric acid, Y-; Aspartic acid, dl-threo-B-hydroxy; Aspartic acid, l-; Cysteine sulfinic acid; Glutamic acid, l-; Radio-isotopes; 3H tracer; Acetate; Saline; CSF/CNS (corpus striatum); CSF/CNS (hippocampus); rat; 2002; 2 weeks; comparison of injec. vs. mp infusion; amino acids infused separately&simultaneously.