References on the Administration of Y-Aminobutyric Acid Using ALZET® Osmotic Pumps
P6975 Ding,R., Tsunekawa,N., Obata,K. Cleft palate by picrotoxin or 3-MP and palatal shelf elevation in GABA-deficient mice. NEUROTOXICOLOGY AND TERATOLOGY 2004; 26(-4-):587-592. >>> Picrotoxin; aminobutyric acid, Y; mercaptopropionic acid, 3-; SC; Mice (pregnant); 1003D; 3 days; Controls received mp w/ saline; comparison of SC injections vs. mp; no stress (see pg. 589); teratology; SC injections induced seizures, during mp infusion mice behaved normally.
P6456 Barcia,J.A., Castillo,A., Gutierrez,R., Gallego,J.M., Ortiz,L., Hernandez,M.E. Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat. Epilepsy Research 2004; 58(-1-):19-26. >>> Aminobutyric acid, Y-; mannitol; Saline; CSF/CNS (amygdala); Rat; 2001; 7 days; Controls received mp w/mannitol; functionality of mp verified by cutting open&visual inspection; dose-response (table 1); no stress (see pg. 25).
P4853 Yang,L., Long,C., Faingold,C.L. Audiogenic seizure susceptibility is induced by termination of continuous infusion of gamma-aminobutyric acid or an N-methyl-D-aspartic acid antagonist into the inferior colliculus. Experimental Neurology 2001; 171(--):147-152. >>> Aminobutyric acid, Y-; AP7; Saline; CSF/CNS (inferior collicus); rat; 1002; 7 days; controls received mp w/ vehicle; AP7 is an NMDA receptor antagonist; seizures; bilateral cannula used; 1 week recovery period from surgery; cannula placement verified at end of experiment by histology.
P3309 Shuaib,A., Ijaz,S., Hasan,S., Kalra,J. Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia. Brain Research 1992; 590(--):13-17. >>> GABA, gamma-vinyl-; Aminobutyric acid, Y-; CSF/CNS (third ventricle); gerbil; 5 days; Ischemia (cerebral).
P2959 Ballough,G., Majchrzak,M., Strauss,J., Kan,R., Anthony,A., Will,B. Cytophotometric analysis of magnocellular azure B-RNA and Feulgen-DNA following chronic GABA infusion into the nucleus basalis of rats. Life Sci. 1992; 50(-18-):1299-1310. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (nucleus basalis magnocellularis); rat; 2001; 24 hours; controls received mp with saline and/or were sham operated; protective cranial cap placed over cannula provided mechanical support and protection; animals allowed 1 week recovery before pump implantation; non-infused hemisphere of each animal served as control for the infused hemisphere.
P2152 Brailowsky,S., Montiel,T., Hernandez-Echeagaray,E., Flores-Hernandez,J., Hernandez-Pineda,R. Effects of a Ginkgo biloba extract on two models of cortical hemiplegia in rats. Restor.Neurol.Neurosci. 1991; 3(--):267-274. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (motor cortex); rat; 2001; 7 days; GABA withdrawal syndrome induced by infusion interruption achieved by disconnecting catheter leading to brain cannula after 24 hours.
P1465 Brailowsky,S., Silva-Barrat,C., Menini,C., Riche,D., Naquet,R. Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio. Electroencephalogr.Clin.Neurophysiol. 1989; 72(--):147-156. >>> Aminobutyric acid, Y-; Saline; CSF/CNS; Monkey (baboon); 2ML1; 7 days; functionality of mp verified by removing and opening; pumps replaced once w/ saline-filled mp.
R0083 Brailowsky,S. Therapeutic approaches in subjects with brain lesions. In 'Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury,' D.G.Stein and B.A.Sabel (eds.), Plenum Press, New York and London 1988; (-Ch. 1-):1-21. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (motor cortex); rat; 2001; 7 days; m.p. infusion is a model for hemiplegia.
P1397 La Salle,G., Brailowsky,S., Menini,C., Naquet,R. Local asymptomatic status epilepticus induced by withdrawal of GABA infusion into limbic structures. Exp.Neurol. 1988; 101(--):411-417. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; 6 days; mp connected to cannula; mp malfunction (pump disconnected after 6 days).
P1314 Brailowsky,S., Kunimoto,M., Menini,C., Silva-Barrat,C., Riche,D., Naquet,R. The GABA-withdrawal syndrome: a new model of focal epileptogenesis. Brain Research 1988; 442(--):175-179. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (cortex); rat; 2001; 3, 5, 7, 14 days and 3, 6, 12, 24 hours; pump replaced once at 7 days; long-term study.
P1297 Will,B.E., Toniolo,G., Brailowsky,S. Unilateral infusion of GABA and saline into the nucleus basalis of rats: 1. effects on motor function and brain morphology. Behav.Brain Research 1988; 27(--):123-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (nucleus basalis); rat; 2001; 4, 10 days; pumps exchanged with control pumps containing saline; comparison of icv injections vs. mp infusion; pump replaced at 4 days.
P1220 Brailowsky,S., Knight,R.T. Recovery from GABA-mediated hemiplegia in young and aged rats: effects of Catecholaminergic manipulations. Neurobiol.Aging 1987; 8(--):441-447. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (cortex); rat; 2001; 7 days; controls received mp w/ saline; mp connected to cannula in cortex.
P1152 Fukuda,H., Brailowsky,S., Menini,C., Silva-Barrat,C., Riche,D., Naquet,R. Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal. Exp.Neurol. 1987; 98(--):120-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; 7 days; controls received mp w/ saline; mp connected to bilateral cannulae; functionality of mp verified.
P1023 Brailowsky,S., Menini,C., Silva-Barrat,C., Naquet,R. Epileptogenic y-aminobutyric acid-withdrawal syndrome after chronic, intracortical infusion in baboons. Neurosci.Lett. 1987; 74(--):75-80. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (frontal cortex); Monkey (baboon); 2ML1; no duration posted; controls received mp w/vehicle; mp connected to intracerebral cannula; agent filled mp replaced after 7 days with saline filled mp; tissue perfusion (frontal cortex).
P0886 Loscher,W. Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacol.Biochem.Behav. 1986; 24(--):1007-1013. >>> Aminobutyric acid, Y-acetylenic Y-; Aminooxyacetic acid; Diazepam; THIP; Valproic acid; Saline; SC; rat; 2ML2; 2 weeks; controls received mp w/saline; diazepam too unstable to be used in mp; epilepsy; functionality of mp verified after 14 day exper. period - all 50 mps worked accurately; stability of VPA, THIP, GAG and AOAA.
P0877 Brailowsky,S., Knight,R.T., Efron,R. Phenytoin increases the severity of cortical hemiplegia in rats. Brain Research 1986; 376(--):71-77. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (somatomotor region); rat; 2001; 7 days; controls rec'd mp w/saline; mp connected to cannula in somatomotor region; mps may have become detached from cannula during study (see p.73).
P0787 Brailowsky,S., Knight,R.T., Blood,K., Scabini,D. g-Aminobutyric acid-induced potentiation of cortical hemiplegia. Brain Research 1986; 362(-2-):322-330. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (somatomotor region); rat; 2001; 7 days; controls received mp w/saline; mp connected to cannula in somatomotor area; functionality verified by completeness of delivery.
P0666 Beart,P.M., Scatton,B., Lloyd,K.G. Subchronic administration of GABAergic agonists elevates (3H)GABA binding and produces tolerance in striatal dopamine catabolism. Brain Research 1985; 335(-1-):169-173. >>> Aminobutyric acid, Y-acetylenic Y-; Aminobutyric acid, Y-vinyl Y-; Kojic amine; Aminooxyacetic acid; Baclofen; THIP; Water; SC; rat; 2001; 2002; 7-14 days; comparison of injec vs. mp infusion; comparison of agents effects; THIP is 4,5,6,7-tetrahydroisoxazolol (5,4-c) pyridin-3-ol; Kojic amine is 2-amino-methyl-5-hydroxy-4H-pyran-4-one.
P0439 Costall,B., Domeney,A.M., Naylor,R.J. Locomotor hyperactivity caused by dopamine infusion into the nucleus accumbens of rat brain: specificity of action. Psychopharmacology 1984; 82(--):174-180. >>> Acetylcholine HCl; Aminobutyric acid, Y-; Serotonin bimaleinate; Dopamine HCl; Norepinephrine bitartrate; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; 13 days; Cholinergic agent; comparison of agents effects; no stress p. 175; stability of substances remaining in pump after 13 days was verified.
P0289 Mangano,R.M., Schwarcz,R. Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus. Brain Res.Bull. 1983; 10(--):47-51. >>> Aminobutyric acid, Y-; Aspartic acid, dl-threo-B-hydroxy; Aspartic acid, l-; Cysteine sulfinic acid; Glutamic acid, l-; Radio-isotopes; 3H tracer; Acetate; Saline; CSF/CNS (corpus striatum); CSF/CNS (hippocampus); rat; 2002; 2 weeks; comparison of injec. vs. mp infusion; amino acids infused separately&simultaneously.
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“In summary, our data demonstrate that the local microinfusion of endostatin is able to inhibit tumor growth and increase survival of animals with orthotopic malignant gliomas.Local continuous i.c. delivery is more effective than daily systemic delivery.” ( p.1255) Schmidt et al., Clinical Cancer Research 2004;10:1255-1262.
