References on the Administration of Y-Aminobutyric Acid Using ALZET® Osmotic Pumps

10852 Gallego, J.M., Ortiz, L., Gutierrez, R., Barcia, J.A. Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 2009; 18(-7-):537-540. >>> Aminobutyric acid, gamma; Saline; CSF/CNS (dorsomedian nuclei of the thalamus); Rat; 2001; Controls received mp w/ vehicle; animal info (adult, male, Wistar); functionality of mp verified by residual volume; multiple pumps per animal (2); bilateral infusion.

8921 Navarro, V., Le Van Quyen, M., Martinerie, J., Rudrauf, D., Baulac, M., Menini, C. Loss of phase synchrony in an animal model of partial status epilepticus. Neuroscience 2007; 148(-1-):304-313. >>> Aminobutyric acid, gamma; Kreb's solution; CSF/CNS (left somatomotor cortex); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 170-190g); epilepsy.

7951 Silva-Barrat, C., Velluti, J., Szente, M., Batini, C., Champagnat, J. Exaggeration of epileptic-like patterns by nicotine receptor activation during the GABA withdrawal syndrome. Brain Research 2005; 1042(-2-):133-143. >>> Aminobutyric acid, gamma; CSF/CNS (somatomotor cortex); Rat; 2001; Controls received mp w/ saline or no treatment; dependence; animal info (male, wistar).

7184 Ding, R., Tsunekawa, N., Obata, K. Cleft palate by picrotoxin or 3-MP and palatal shelf elevation in GABA-deficient mice. NEUROTOXICOLOGY AND TERATOLOGY 2004; 26(-4-):587-592. >>> Picrotoxin; aminobutyric acid, Y; mercaptopropionic acid, 3-; SC; Mice (pregnant); 1003D; Controls received mp w/ saline; comparison of SC injections vs. mp; no stress (see pg. 589); teratology; SC injections induced seizures, during mp infusion mice behaved normally.

6592 Barcia, J.A., Castillo, A., Gutierrez, R., Gallego, J.M., Ortiz, L., Hernandez, M.E. Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat. Epilepsy Research 2004; 58(-1-):19-26. >>> Aminobutyric acid, Y-; mannitol; Saline; CSF/CNS (amygdala); Rat; 2001; Controls received mp w/mannitol; functionality of mp verified by cutting open&visual inspection; dose-response (table 1); no stress (see pg. 25).

4963 Yang, L., Long, C., Faingold, C.L. Audiogenic seizure susceptibility is induced by termination of continuous infusion of gamma-aminobutyric acid or an N-methyl-D-aspartic acid antagonist into the inferior colliculus. Experimental Neurology 2001; 171(--):147-152. >>> Aminobutyric acid, Y-; AP7; Saline; CSF/CNS (inferior collicus); rat; 1002; controls received mp w/ vehicle; AP7 is an NMDA receptor antagonist; seizures; bilateral cannula used; 1 week recovery period from surgery; cannula placement verified at end of experiment by histology; bilateral infusion;.

3417 Shuaib, A., Ijaz, S., Hasan, S., Kalra, J. Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia. Brain Research 1992; 590(--):13-17. >>> GABA, gamma-vinyl-; Aminobutyric acid, Y-; CSF/CNS (third ventricle); gerbil; Ischemia (cerebral).

3062 Ballough, G., Majchrzak, M., Strauss, J., Kan, R., Anthony, A., Will, B. Cytophotometric analysis of magnocellular azure B-RNA and Feulgen-DNA following chronic GABA infusion into the nucleus basalis of rats. Life Sci 1992; 50(-18-):1299-1310. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (nucleus basalis magnocellularis); rat; 2001; controls received mp with saline and/or were sham operated; protective cranial cap placed over cannula provided mechanical support and protection; animals allowed 1 week recovery before pump implantation; non-infused hemisphere of each animal served as control for the infused hemisphere.

2146 Brailowsky, S., Montiel, T., Hernandez-Echeagaray, E., Flores-Hernandez, J., Hernandez-Pineda, R. Effects of a Ginkgo biloba extract on two models of cortical hemiplegia in rats. Restor. Neurol. Neurosci 1991; 3(--):267-274. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (motor cortex); rat; 2001; GABA withdrawal syndrome induced by infusion interruption achieved by disconnecting catheter leading to brain cannula after 24 hours.

1464 Brailowsky, S., Silva-Barrat, C., Menini, C., Riche, D., Naquet, R. Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio. Electroencephalogr. Clin. Neurophysiol 1989; 72(--):147-156. >>> Aminobutyric acid, Y-; Saline; CSF/CNS; Monkey (baboon); 2ML1; functionality of mp verified by removing and opening; pumps replaced once w/ saline-filled mp.

1397 La Salle, G., Brailowsky, S., Menini, C., Naquet, R. Local asymptomatic status epilepticus induced by withdrawal of GABA infusion into limbic structures. Exp. Neurol 1988; 101(--):411-417. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; mp connected to cannula; mp malfunction (pump disconnected after 6 days).

1314 Brailowsky, S., Kunimoto, M., Menini, C., Silva-Barrat, C., Riche, D., Naquet, R. The GABA-withdrawal syndrome: a new model of focal epileptogenesis. Brain Research 1988; 442(--):175-179. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (cortex); rat; 2001; pump replaced once at 7 days; long-term study.

1297 Will, B.E., Toniolo, G., Brailowsky, S. Unilateral infusion of GABA and saline into the nucleus basalis of rats: 1. effects on motor function and brain morphology. Behav. Brain Research 1988; 27(--):123-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (nucleus basalis); rat; 2001; pumps exchanged with control pumps containing saline; comparison of icv injections vs. mp infusion; pump replaced at 4 days.

1220 Brailowsky, S., Knight, R.T. Recovery from GABA-mediated hemiplegia in young and aged rats: effects of Catecholaminergic manipulations. Neurobiol. Aging 1987; 8(--):441-447. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (cortex); rat; 2001; controls received mp w/ saline; mp connected to cannula in cortex.

15408 Fukuda, H., Brailowsky, S., Menini, C., Silva-Barrat, C., Riche, D., Naquet, R. Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal. Exp. Neurol 1987; 98(--):120-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; controls received mp w/ saline; mp connected to bilateral cannulae; functionality of mp verified.

1152 Fukuda, H., Brailowsky, S., Menini, C., Silva-Barrat, C., Riche, D., Naquet, R. Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal. Exp. Neurol 1987; 98(--):120-129. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (amygdala); rat; 2001; controls received mp w/ saline; mp connected to bilateral cannulae; functionality of mp verified.

1023 Brailowsky, S., Menini, C., Silva-Barrat, C., Naquet, R. Epileptogenic y-aminobutyric acid-withdrawal syndrome after chronic, intracortical infusion in baboons. Neurosci. Lett 1987; 74(--):75-80. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (frontal cortex); Monkey (baboon); 2ML1; controls received mp w/vehicle; mp connected to intracerebral cannula; agent filled mp replaced after 7 days with saline filled mp; tissue perfusion (frontal cortex).

886 Loscher, W. Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacol. Biochem. Behav 1986; 24(--):1007-1013. >>> Aminobutyric acid, Y-acetylenic Y-; Aminooxyacetic acid; Diazepam; THIP; Valproic acid; Saline; SC; rat; 2ML2; controls received mp w/saline; diazepam too unstable to be used in mp; epilepsy; functionality of mp verified after 14 day exper. period - all 50 mps worked accurately; stability of VPA, THIP, GAG and AOAA.

877 Brailowsky, S., Knight, R.T., Efron, R. Phenytoin increases the severity of cortical hemiplegia in rats. Brain Research 1986; 376(--):71-77. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (somatomotor region); rat; 2001; controls rec'd mp w/saline; mp connected to cannula in somatomotor region; mps may have become detached from cannula during study (see p.73).

787 Brailowsky, S., Knight, R.T., Blood, K., Scabini, D. g-Aminobutyric acid-induced potentiation of cortical hemiplegia. Brain Research 1986; 362(-2-):322-330. >>> Aminobutyric acid, Y-; Saline; CSF/CNS (somatomotor region); rat; 2001; controls received mp w/saline; mp connected to cannula in somatomotor area; functionality of mp verified by completeness of delivery.

666 Beart, P.M., Scatton, B., Lloyd, K.G. Subchronic administration of GABAergic agonists elevates (3H)GABA binding and produces tolerance in striatal dopamine catabolism. Brain Research 1985; 335(-1-):169-173. >>> Aminobutyric acid, Y-acetylenic Y-; Aminobutyric acid, Y-vinyl Y-; Kojic amine; Aminooxyacetic acid; Baclofen; THIP; Water; SC; rat; 2001; 2002; comparison of injec vs. mp infusion; comparison of agents effects; THIP is 4,5,6,7-tetrahydroisoxazolol (5,4-c) pyridin-3-ol; Kojic amine is 2-amino-methyl-5-hydroxy-4H-pyran-4-one.

439 Costall, B., Domeney, A.M., Naylor, R.J. Locomotor hyperactivity caused by dopamine infusion into the nucleus accumbens of rat brain: specificity of action. Psychopharmacology 1984; 82(--):174-180. >>> Acetylcholine HCl; Aminobutyric acid, Y-; Serotonin bimaleinate; Dopamine HCl; Norepinephrine bitartrate; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; Cholinergic agent; comparison of agents effects; no stress p. 175; stability of substances remaining in pump after 13 days was verified.

 

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What researchers are saying...

“However formoterol administered intraperitoneally twice a day did not influence LPS-induced premature delivery (data not shown). Osmotic Pumps can maintain the blood concentration of formoterol for over 20h. Thus, it may be of importance that formoterol was continuously and uniformly administered.” (p. 201) Shinkai et al., Reproduction 2003;125:199-203.