References on the Administration of Growth Factors Using ALZET® Osmotic Pumps

1. Epidermal Growth Factor

Q3843 Clausen,F., Lindh,T., Salimi,S., Erlandsson,A., Erlandsson,A. Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration. Brain Research 2014; 1588(--):37-46. >>> Epidermal growth factor, recombinant human; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ saline or no mp w/ sham surgery; animal info (male, Sprague Dawley, 330-400g); ALZET brain infusion kit 2 used; behavioral testing (morris water maze); pumps removed after 7 days; traumatic brain injury;.

Q3799 Alluin,O., ivet-Mongrain,H., Gauthier,M.K., Fehlings,M.G., Rossignol,S., Karimi-Abdolrezaee,S., Karimi-Abdolrezaee,S. Examination of the Combined Effects of Chondroitinase ABC, Growth Factors and Locomotor Training following Compressive Spinal Cord Injury on Neuroanatomical Plasticity and Kinematics. PLoS One 2014; 9(--):U603-U621. >>> Chondroitinase ABC; platelet-derived growth factor-AA; basic fibroblast growth factor; epidermal growth factor;; Saline; rat serum albumin; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 250-275g); spinal cord injury; behavioral testing (treadmill locomotion; coordination); used ALZET rat intrathecal catheter;.

Q3518 Jeffers,M.S., Hoyles,A., Morshead,C., Corbett,D., Corbett,D. Epidermal Growth Factor and Erythropoietin Infusion Accelerate Functional Recovery in Combination With Rehabilitation. Stroke 2014; 45(--):185-+. >>> Epidermal Growth Factor; erythropoietin; CSF, artificial; CSF/CNS; Rat; 2001; 14 days; Animal info (male, Sprague Dawley); pumps replaced every 7 days; ischemia (cerebral); behavioral testing (staircase test); pumps removed 7 days after serial implantation;.

Q3481 Giachino,C., Basak,O., Lugert,S., Knuckles,P., Obernier,K., Fiorelli,R., Frank,S., Raineteau,O., varez-Buylla,A., Taylor,V., Taylor,V. Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population. Stem Cells 2014; 32(--):70-84. >>> Epidermal growth factor; Albumin; SC; Rabbit; 6 days; Controls received mp w/ vehicle; replacement therapy (enterectomy); no stress (see pg. 258-259).

P7424 Takemura,N.U. Evidence for neurogenesis within the white matter beneath the temporal neocortex of the adult rat brain. Neuroscience 2005; 134(-1-):121-132. >>> Epidermal growth factor; fibroblast growth factor-2; CSF, artificial; albumin, rat serum; CSF/CNS; Rat; 1003D; 3 days; Animal info (male, wistar, 11-12 weeks old, 260-280 g); Plastics One Cannula used.

P7181 Hewitt,S.C., Collins,J., Grissom,S., Deroo,B., Korach,K.S. Global uterine Genomics in vivo: Microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. MOLECULAR ENDOCRINOLOGY 2005; 19(-3-):657-668. >>> Epidemal growth factor; insulin-like growth factor-1, LR3-; Acetic acid; IP; Mice; 24 hours; Controls received mp w/ vehicle; comparison of IP injections vs. mp.

P7178 Cellini,C., Xu,J., Arriaga,A., Buchmiller-Crair,T.L., Buchmiller-Crair,T.L. Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development. Journal of Pediatric Surgery 2004; 39(-6-):891-897. >>> Epidermal growth factor, recomb.human; BSA; Intra-amniotic; Rabbit (pregnant); 2ML1; 7 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; no stress (see pg. 893); teratology; peptides; multiple pumps per animal (4).

P6989 Enwere,E., Shingo,T., Gregg,C., Fujikawa,H., Ohta,S., Weiss,S. Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. Journal of Neuroscience 2004; 24(-38-):8354-8365. >>> Epidermal growth factor, human recomb.; Ara-C; Saline; albumin, mouse serum; CSF/CNS; Mice; 1003D; 3 days; Controls received mp w/ vehicle; peptides.

P6924 Avissar,N.E., Ziegler,T.R., Toia,L., Gu,L., Ray,E.C., Berlanga-Acosta,J., Sax,H.C. ATBO/ASCT2 expression in residual rabbit bowel is decreased after massive enterectomy and is restored by growth hormone treatment. Journal of Nutrition 2004; 134(-9-):2173-2177. >>> Epidermal growth factor; Albumin; SC; Rabbit; 2ML2; 2 weeks.

P6712 Bashir,O., FitzGerald,A.J., Berlanga-Acosta,J., Playford,R.J., Goodlad,R.A. Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. Clinical Science 2003; 105(-3-):323-330. >>> Epidermal growth factor, recomb. human; SC; Mice; 2004; 4 weeks; Controls received mp w/ saline; cancer (intestinal adenoma; colon); peptides.

P6493 Rooman,I., Bouwens,L. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 2004; 47(-2-):259-265. >>> Gastrin I, rat; epidermal growth factor, recomb. human; DMSO; saline, physiological; acetic acid; BSA; IP; Mice; 1007D; 1 week; Controls received no treatment; peptides; 8% DMSO.

P6377 Jin,K.L., Sun,Y.J., Xie,L., Childs,J., Mao,X.O., Greenberg,D.A. Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism 2004; 24(-4-):399-408. >>> Epidermal growth factor, heparin binding; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral).

P6364 Gregg,C., Weiss,S. Generation of functional radial glial cells by embryonic and adult forebrain neural stem cells. Journal of Neuroscience 2003; 23(-37-):11587-11601. >>> Fibroblast growth factor-2; epidermal growth factor; transforming growth factor; Saline; serum albumin; CSF/CNS; Mice; 1007D; 6,12 days; Pumps replaced at day 7 for 12 d EGF infusions.

P6307 Rayn,C.K., Miller,J.H., Seydel,A.S., Jensen,K., Sax,H.C. Epidermal Growth Factor and Neurotensin Induce Microvillus Hypertrophy Following Massive Enterectomy. JOURNAL OF GASTROINTESTINAL SURGERY 1996; 1(-5-):467-473. >>> Epidermal growth factor; neurotensin; Saline; SC; Rabbit; 1 week; Controls received mp w/ vehicle; replacement therapy (enterectomy); good methods p.468; peptides; post op. care (IM gentamycin; IV banamine).

P6007 Ray,E.C., Avissar,N.E., Vukcevic,D., Toia,L., Ryan,C.K., Berlanga-Acosta,J., Sax,H.C. Growth hormone and epidermal growth factor together enhance amino acid transport systems B0,+ and a in remnant small intestine after massive enterectomy. Journal of Surgical Research 2003; 115(-1-):164-170. >>> Epidermal growth factor; Albumin; SC; Rabbit; 2 weeks; Controls received mp w/ vehicle; pump model not listed; EGF in 2% albumin.

P5952 Yang,J., Zhao,J.B., Zeng,Y.J., Gregersen,H. Biomechanical properties of ileum after systemic treatment with epithelial growth factor. WORLD JOURNAL OF GASTROENTEROLOGY 2003; 9(-10-):2278-2283. >>> Epidermal growth factor; SC; Rat; 2001; 2,4,7,14 days; Controls received mp w/ vehicle; pumps replaced once after 7 days for the 14 day study; peptides; EGF was human recomb..

P5915 Calza,L., Giuliani,A., Fernandez,M., Pirondi,S., D'Intino,G., Aloe,L., Giardino,L. Neural stem cells and cholinergic neurons: Regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O F AMERICA 2003; 100(-12-):7325-7330. >>> Epidermal growth factor; fibroblast growth factor, basic; Nerve growth factor; PBS, sterile; CSF/CNS; Rat; 2002; 28; Controls received mp w/ aCSF; pumps replaced every 14 days for 28 days; ALZET brain infusion kit used; peptides; behavioral study; NGF dissolved in PBS; EGF&FGF were infused for 14 days, followed by a 14 day infusion of NGF; stem cell related study.

P5739 Zhao,J.B., Yang,J., Vinter-Jensen,L., Zhuang,F.Y., Gregersen,H. The morphometry and biomechanical properties of the rat small intestine after systemic treatment with epidermal growth factor. Biorheology 2002; 39(-6-):719-733. >>> Epidermal growth factor; SC; Rat; 2001; 14 days; Controls received mp w/ saline; peptides.

P5681 Teramoto,T., Qu,J.H., Plumier,J.C., Moskowitz,M.A. EGF amplifies the replacement of parvalbumin-expressing striatal inter neurons after ischemia. Journal of Clinical Investigation 2003; 111(-8-):1125-1132. >>> Epidermal growth factor; PBS; BSA; CSF/CNS; Mice; 1007D; 7 days; peptides; ALZET brain infusion kit 2 used; 1mg/ml of albumin was added as carrier to solution to prevent degradation; ischemia (cerebral).

P5612 Yang,J., Zhao,J.B., Zeng,Y.J., Vinter-Jensen,L., Gregersen,H. Morphological properties of zero-stress state in rat large intestine during systemic EGF treatment. Digestive Diseases and Sciences 2003; 48(-3-):442-448. >>> Epidermal growth Factor; Saline; SC; Rat; 2001; 1 week; Controls received mp/w vehicle; peptides; EGF is human recombinant.

P5596 Doetsch,F., Petreanu,L., Caille,I., Garcia-Verdugo,J.M., Alvarez-Buylla,A. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 2002; 36(-6-):1021-1034. >>> Epidermal growth factor; Ganciclovir; Saline; BSA; PBS; CSF/CNS; Mice; 1007D; 1002; 7 hours; 6 days; Controls received mp w/ vehicle; Gene therapy; peptides; EGF was diluted in BSA-containing saline and infused for 7 hours, or 6 days in 1007D pumps; Ganciclovir was diluted in PBS and infused for 6 days via 1002 pumps.

P5433 Nakatomi,H., Kuriu,T., Okabe,S., Yamamoto,S., Hatano,O., Kawahara,N., Tamura,A., Kirino,T., Nakafuku,M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002; 110(-4-):429-441. >>> Fibroblast growth factor 2; Epidermal growth factor; Ara-C; CSF, artificial; Albumin, rat serum; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; Ara-C is also called cytosine beta-D-arabinofuranoside (antimitotic drug); ischemia (cerebral).

P5392 Martens,D.J., Seaberg,R.M., van der Kooy,D. In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord. European Journal of Neuroscience 2002; 16(-6-):1045-1057. >>> Fibroblast growth factor 2; Epidermal growth factor;; Saline; Albumin, mouse; heparin; CSF/CNS (fourth ventricle); CSF/CNS; Mice; 6 days; Controls received mp w/ vehicle; peptides; EGF and FGF were infused alone or together, with or without heparin; heparin was added to prevent FGF degradation and to help present FGF to its receptor.

P5350 Bachoo,R.M., Maher,E.A., Ligon,K.L., Sharpless,N.E., Chan,S.S., You,M.J.J., Tang,Y., DeFrances,J., Stover,E., Weissleder,R., Rowitch,D.H., Louis,D.N., DePinho,R.A. Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. CANCER CELL 2002; 1(-3-):269-277. >>> Epidermal growth factor; Saline; albumin, mouse serum; CSF/CNS; Mice; 1007D; 7 days; Peptides.

P5259 Kuhn,H.G., Winkler,J., Kempermann,G., Thal,L.J., Gage,F.H. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci. 1997/8/1; 17(-15-):5820-5829. >>> Epidermal growth factor; Fibroblast growth factor; CSF, artificial; Albumin, rat serum; Gentamicin; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides.

P5220 Kojima,A., Tator,C.H. Intrathecal administration of epidermal growth factor and fibroblast growth factor 2 promotes ependymal proliferation and functional recovery after spinal cord injury in adult rats. J Neurotrauma 2002/2; 19(-2-):223-238. >>> Epidermal growth factor; Fibroblast growth factor 2; Albumin, rat serum; Gentamicin sulfate; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; 3 or 14 days; Controls received mp w/ vehicle; good methods (p. 224); lynch coil used; pump filled w/ saline; mineral oil spacer used to separate saline in pump from agent solution in catheter; agents infused separatedly or concomittantly in the same pump; spinal cord injury.

P4956 Pedersen,S.B., Kristensen,K., Bruun,J.M., Flyvbjerg,A., Vinter-Jensen,L., Richelsen,B. Systemic administration of epidermal growth factor increases UCP3 mRNA levels in skeletal muscle and adipose tissue in rats. Biochemical and Biophysical Research Communications 2000; 279(--):914-919. >>> Epidermal growth factor; Acetic acid; SC; rat; 7 days; controls received mp w/ placebo; peptides; acetic acid vehicle was 0.1 M.

P4934 Berlanga-Acosta,J., Playford,R.J., Mandir,N., Goodlad,R.A. Gastrointestinal cell proliferation and crypt fission are separate but complementary means of increasing tissue mass following infusion of epidermal growth factor in rats. Gut 2001; 48(--):803-807. >>> Epidermal growth factor; Saline; SC; rat; 2ML2; 14 days; controls received mp w/ vehicle; peptides; cancer.

P4607 Kristensen,K, Pedersen,S.B, Vinter-Jensen,L, Flyvbjerg,A, Richelsen,B. Systemic administration of epidermal growth factor reduces fat mass in rats: effects on the hormone-sensitive-lipase, lipoprotein lipase and leptin.. Horm.Res. 1998/5/25; 50(--):292-296. >>> Epidermal growth factor;; Acetic acid;; SC;; rat;; 7 days;; controls received mp w/vehicle;.

P4130 Roelofs,M., Faggian,L., Pampinella,F., Paulon,T., Franch,R., Chiavegato,A., Sartore,S. Transforming growth factor b1 involvement in the conversion of fibroblasts to smooth muscle cells in the rabbit bladder serosa. Histochemical J. 1998; 30(--):393-404. >>> Transforming growth factor-B1; Epidermal growth factor; Fibroblast growth factor, basic; Colony-stimulating factor, G; Platelet-derived growth factor; Colony-stimulating factor, GM; PBS; bladder wall; rabbit; 2ML2; 2ML4; no duration posted; controls received mp w/PBS; no stress (see pg. 395); "a minipump filled with Evans Blue solution was used to determine area of growth factor delivery"; peptides; tissue perfusion (bladder wall).

P4116 Herrington,M.K., Joekel,C.S., Adrian,T.E. Effects of epidermal growth factor on neonatal pancreatic growth in the guinea pig. Int.J.Pancreatology 1998; 24(-1-):35-41. >>> Epidermal growth factor; Devazepide; DMSO; Ringer's solution, lactated; SC; guinea-pig (neonate); 1003D; 2002; 4,15 days; peptides.

P4105 Pastore,C.J., Isner,J.M., Bacha,P.A., Kearney,M., Pickering,J.G. Epidermal growth factor receptor-targeted cytotoxin inhibits neointimal hyperplasia in vivo. Circ.Res. 1995; 77(--):519-529. >>> Epidermal growth factor, receptor-targ. cytotoxin; IV (jugular); rat; 7,14 days; also called DAB389 EGF; vinyl tubing used; dose-response (p. 520); cardiovascular.

P4099 Jansen,C., Ihse,I., Axelson,J. Epidermal growth factor induces increased mucosal thickness of the small intestine in mouse. Eur.Surg.Res. 1997; 29(--):447-454. >>> Epidermal growth factor; Thymidine; 3H tracer; Radio-isotopes; SC; IP; mice; 1003D; 2001; 1, 3, 7 days; peptides; recomb. human EGF used.

P4086 Kitagawa,Y., Ueda,M., Ando,N., Ozawa,S., Kitajima,M. Effect of endogenous and exogenous EGF on the growth of EGF receptor-hyperproducing human squamous cell carcinoma implanted in nude mice. Br.J.Cancer 1995; 72(--):865-868. >>> Epidermal growth factor, mouse; Saline; SC; Mice (nude); 9 days; controls received mp w/vehicle; functionality of mp verified by plasma levels; replacement therapy (sialoadenectomy); cancer; peptides.

P4081 Swaniker,F., Guo,W., Diamond,J., Fonkalsrud,E.W. Delayed effects of epidermal growth factor after extensive small bowel resection. J.Pediatr.Surg. 1996; 31(-1-):56-60. >>> Epidermal growth factor; Saline; SC; rabbit; 7 days; peptides.

P4034 Herrington,M.K., Permert,J., Kazakoff,K.R., Pour,P.M., Zuker,K.A., Bilchik,A.J., Adrian,T.E. Effects of high fat diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster. Carcinogenesis 1993; 14(-5-):1021-1026. >>> Devazepide; DMSO; SC; hamster; 2002; 14 days; CCK receptor antagonist; controls received mp w/vehicle; cancer; peptides.

P3999 Kojima,Y., Tojo,M., Goldmann,D.A., Tosteson,T.D., Pier,G.B. Antibody to the capsular polysaccharide/adhesin protects rabbits against catheter-related bacteremia due to coagulase-negative staphylococci. J.Infect.Dis. 1990; 162(--):435-441. >>> Bacteria, staphylococcus epidermis; Antibody, anti-polysaccharide/adhesin; Heparin; Serum, rabbit; IV (jugular); rabbit; 2ML1; 7 days; induction of bacteremia with infected i.v. catheters; immunology; peptides; some animals received 2 catheter-pump combinations concomitantly - 1 w/heparin infused through infected catheter tubing, and the second w/antibody or rabbit serum infused via sterile catheter tubing.

P3923 Kato,Y., Yu,D., Schwartz,M.Z. Growth factor enhancement of intestinal function: dramatic response but lack of synergism. J.Pediatr.Surg. 1997; 32(--):1598-1600. >>> Epidermal growth factor; Gastrin I, human synthetic; IV (jugular); rat; 2002; 14 days; controls received mp w/ saline; peptides; multiple pumps per animal (2) to infuse both agents simultaneously; recomb. human EGF used.

P3922 Dunn,J.C.Y., Parungo,C.P., Fonkalsrud,E.W., McFadden,D.W., Ashley,S.W. Epidermal growth factor selectively enhances functional enterocyte adaptation after massive small bowel resection. J.Surg.Res. 1997; 67(--):90-93. >>> Epidermal growth factor; Saline; IP; rat; 7 days; controls received mp w/ saline; no stress (see pg. 91); peptides; recomb. human EGF used.

P3876 Lukish,J., Schwartz,M.Z., Rushin,J.M., Riordan,G.P. A comparison of the effect of growth factors on intestinal function and structure in short bowel syndrome. J.Pediatr.Surg. 1997; 32(-11-):1652-1655. >>> Epidermal growth factor; Insulin-like growth factor I; Intestine (small intestine); rat; 2002; 14 days; controls received mp w/saline; peptides.

P3638 Lopez,D., House,A.K. Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo. Int.J.Oncology 1996; 9(--):815-819. >>> Epidermal growth factor; IP; IV (jugular); rat; 2ML4; no duration posted; Controls received sham procedure; comparison of oral delivery vs. mp; cancer; peptides.

P3635 Ohlsson,B., Axelson,J., Rehfeld,J.F., Ihse,I. Devazepide-induced hyperplasia in the rat liver and bile ducts. Eur.Surg.Res. 1996; 28(--):299-305. >>> Cholecystokinin-8S; Devazepide; Albumin, bovine serum; DMSO; SC; rat; 2001; 2002; 2ML2; 1003D; 36 hours, 3, 7, 28 days; controls received mp w/ saline or DMSO; peptides.

P3552 Ohlsson,B., Jansen,C., Ihse,I., Axelson,J. Epidermal growth factor induces cell proliferation in mouse pancreas and salivary glands. Pancreas 1997; 14(-1-):94-98. >>> Epidermal growth factor; Thymidine; 3H tracer; Radio-isotopes; SC; IP; mice; 2001; 1003D; 1, 3, 7 days; Controls received no treatment; peptides; human recomb. EGF used; EGF&[3H]-thymidine given concomitantly.

P3390 Sawniker,F., Guo,W., Fonkalsrud,E.W., Diamond,J. The effect of epidermal growth factor on mucosal function after ileal resection. J.Surg.Res. 1995; 58(--):565-569. >>> Epidermal growth factor; SC; rabbit; 7 days; peptides; human recomb. EGF used.

P3386 Paschke,R., Eck,T., Herfurth,J., Usadel,K.-H. Stimulation of proliferation and inhibition of function of xenotransplanted human thyroid tissue by epidermal growth factor. J.Endocrinol.Invest. 1995; 18(--):359-363. >>> Epidermal growth factor; SC; Mice (nude); 7 days; comparison of IP injections vs. mp; half-life (p.362); peptides.

P3327 Ohlsson,B., Axelson,J., Sternby,B., Rehfeld,J.F., Ihse,I. Time-course of the pancreatic changes following long-term stimulation or inhibition of the CCK-A receptor. Int.J.Pancreatology 1995; 18(-1-):59-66. >>> Cholecystokinin-8; Devazepide; Cholecystokinin-8S; DMSO; Albumin, bovine serum; SC; rat; 2001; 2002; 2ML2; 1003D; 3, 7, 28 days; 36 hrs; controls received mp w/NaCl or DMSO; pumps replaced after 14 days; peptides.

P3291 Norman J., Tsau,Y., Bacay,A., Fine,L.G. Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: role of the epidermal growth factor receptor. Clin.Sci. 1990; 78(--):445-450. >>> Epidermal growth factor; Saline; IA (renal); rat; 2001; 8 days; controls received mp w/saline; peptides; medical category: renal; skc.

P3256 Craig,C.G., Tropepe,V., Morshead,C.M., Reynolds,B.A., Weiss,S., van der Kooy,D. In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J.Neurosci. 1996; 16(-8-):2649-2658. >>> Epidermal growth factor; Transforming growth factor-a; Fibroblast growth factor; Nerve growth factor; Saline; Albumin, mouse serum; CSF/CNS; mice; 1007D; 6 days; controls received no pumps or mp w/vehicle; peptides; mouse EGF used; human recomb. basic FGF used; mouse 7S NGF used; human recomb. TGF-alpha used.

P3148 Adachi,H., Kurachi,H., Homma,H., Adachi,K., Imai,T., Sakata,M., Matsuzawa,Y., Miyake,A. Involvement of epidermal growth factor in inducing adiposity of aged female mice. J.Endocrinol. 1995; 146(--):381-393. >>> Epidermal growth factor; Saline; mice; 3 weeks; controls received sham operation + mp with saline; peptides; mouse EGF used.

P3129 Thompson,J.S., Nguyen,B.-L.T., Harty,R.F. Somatostatin analogue inhibits intestinal regeneration. Arch Surg 1993; 128(--):385-389. >>> Epidermal growth factor; SC; rabbit; 2ML1; 7 days; functionality of mp verified by aspiration; peptides; ampicillin and supplemental sc fluid given prophylactically.

P2993 Sonis,S.T., Costa,J.W., Evitts,S.M., Lindquist,L.E., Nicolson,M. Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy. Oral Surg Oral Med Oral Pathol 1992; 74(--):749-755. >>> Epidermal growth factor; buccal; hamster; 7,14 days; controls received mp w/ vehicle; no stress (see pg. 750); cancer; peptides; pump implanted between retractor and platysma cervicate muscles; blunted cannula protruded through surgical site by 3 mm; in vitro dye studies performed; recomb. human EGF used.

P2912 Okuda,T., Onda,M., Tokunaga,A., Sugisaki,Y. Stimulatory effect of EGF and inhibitory effect of sialoadenectomy on growth of an EGF receptor-hyperproducing human gastric cancer xenograft in nude mice. Jpn.J.Surg. 1994; 24(--):725-733. >>> Epidermal growth factor; PBS; SC; Mice (nude); 2002; no duration posted; controls received mp with PBS; dose response; cancer; peptides; tissue perfusion (tumor); human EGF used.

P2823 Popnikolov,N.K., Yang,J., Guzman,R.C., Swanson,S.M., Thordarson,G., Collins,G., Talamantes,F., Nandi,S. In vivo growth stimulation of collagen gel embedded normal human and mouse primary mammary epithelial cells. J.Cell.Physiology 1995; 163(--):51-60. >>> Epidermal growth factor; Cortisol; Toxin, cholera; Uridine, bromodeoxy-;; Medium 199;; SC; gel;; Mice (nude);; 1003D;; 3 days;; peptides; "tissue perfusion" -- gel containing human mammary epithelial cells was infused; estradiol, progesterone, and cholesterol combinations administered via silastic capsules EGF cholera toxin and hydrocortisone stimulated DNA synthesis substantially with the greatest response seen in the gel proximal to the pump: local delivery appears to be superior to injection;.

P2698 Hadjiconstantinou,M., Fitkin,J.G., Dalia,A., Neff,N.H. Epidermal growth factor enhances striatal dopaminergic parameters in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse. J.Neurochem. 1991; 57(-2-):479-482. >>> Epidermal growth factor; Cytochrome C; CSF, artificial; CSF/CNS; mice; 2002; 2 weeks; controls received mp w/ vehicle and/or cytochrome C; or were unlesioned; good methods (pg. 479-480); peptides.

P2665 Buchmiller,T.L., Shaw,K.S., Chopourian,H.L., Lloyd,K.C.K., Gregg,J.P., Rivera Jr,F.A., Lam,M.L., Diamond,J.M., Fonkalsrud,E.W. Effect of transamniotic administration of epidermal growth factor on fetal rabbit small intestinal nutrient transport and disaccharidase development. J.Pediatr.Surg. 1993; 28(-10-):1239-1244. >>> Epidermal growth factor; Albumin, rabbit serum; intrauterine; rabbit (pregnant); rabbit (fetus); 2ML2; no duration posted; controls received mp w/ vehicle; tissue perfusion (uterus-ovarian end); functionality of mp verified by residual solution; peptides; pump implanted in maternal ip cavity, but flanged catheter placed in amniotic fluid of ovarian end fetus; recomb. human EGF used.

P2535 Chaet,M.S., Arya,G., Ziegler,M.M., Warner,B.W. Epidermal growth factor enhances intestinal adaptation after massive small bowel resection. J.Pediatr.Surg. 1994; 29(-8-):1035-1039. >>> Epidermal growth factor; Saline; SC; rat; 2ML4; 28 days; controls received mp w/ vehicle and sham surgery; peptides; recomb. human EGF used.

P2526 Alarid,E.T., Chen,P., Schaudies,R.P., Nicoll,C.S. Differential effects of an antiserum to epidermal growth factor on the development of transplanted rat embryos and fetal structures in vivo. Growth Factors 1993; 8(--):235-243. >>> Antibody, anti-epidermal growth factor; Epidermal growth factor; Water; Glycerol; Sodium nitrate; Heparin; Albumin; IA (renal); rat; 2002; 14 days; tissue perfusion (fetal tissue transplants); peptides.

P2420 Robinson,S.P., Dean,B.J., Petty,B.A. Characterization of the A431 tumor xenograft as an in vivo model for testing epidermal growth factor-receptor antagonists. Int.J.Oncology 1992; 1(--):293-298. >>> Epidermal growth factor; Saline; SC; mice; 14 days; functionality of mp verified by serum levels, (p. 295); cancer; peptides.

P2369 Morin,N.J., Laurent,G., Nonclercq,D., Toubeau,G., Heuson-Stiennon,J.-A., Bergeron,M.G., Beauchamp,D. Epidermal growth factor accelerates renal tissue repair in a model of gentamicin nephrotoxicity in rats. Am.Physiol.Soc. 1992; (--):F809-F811. >>> Epidermal growth factor; Saline; SC; rat; 2001; 8 days; controls received mp w/ saline; peptides; mouse EGF used.

P2352 Luck,M.S., Bass,P. Effect of epidermal growth factor on experimental colitis in the rat. J.Pharmacol.Exp.Ther. 1993; 264(-2-):984-990. >>> Epidermal growth factor; Saline; SC; rat; 2ML1; 7 days; controls received mp w/ vehicle; comparison of sc injections vs. mp; peptides.

P2231 Bamba,T., Tsujikawa,T., Hosoda,S. Effect of epidermal growth factor by different routes of administration on the small intestinal mucosa of rats fed elemental diet. Gastroenterol.Jpn. 1993; 28(--):511-517. >>> Epidermal growth factor; Saline; Intestine; IP; SC; rat; 2001; 1 week; controls received mp w/saline; stress/adverse reaction: sc pump surrounded by mass which may have been caused by increased collagen and fibroblast formation; tissue perfusion (intestine).

P2041 Robinson,S.P., Rose,W.C., Casazza,A. In vivo evaluation of epidermal growth factor and transforming growth factor B1 in mouse tumor models. J.Steroid Biochem.Molec.Biol. 1990; 37(-6-):883-887. >>> Epidermal growth factor; PBS; SC; mice; 14,20,28 days; dose-response (table p. 886); pumps replaced at 14 days; cancer; peptides.

P1807 Foster,H.McA., Whitehead,R.H. Intravenous but not intracolonic epidermal growth factor maintains colonocyte proliferation in defunctioned rat colorectum. Gastroenterology 1990; 99(--):1710-1714. >>> Epidermal growth factor; PBS; intestine (colon); IV (jugular); rat; 11 days; functionality of mp verified by sectioning spent pumps; peptides; tissue perfusion.

P1717 Tsujikawa,T., Bamba,T., Hosoda,S. The trophic effect of epidermal growth factor on morphological changes and ployamine metabolism in the small intestine of rats. Gastroenterol.Jpn. 1990; 25(-3-):328-334. >>> Epidermal growth factor; Saline; IP; rat; 2001; 1 week; comparison of sc injections vs. mp; stress/adverse reaction: hematoma lesions observed after sc pump insertion (p. 329).

P1715 Kingsnorth,A.N., Vowles,R., Nash,J.R.G. Epidermal growth factor increases tensile strength in intestinal wounds in pigs. Br.J.Surg. 1990; 77(--):409-412. >>> Epidermal growth factor; Saline; IP; pig; 5 days; paper incorrectly describes a 4ml capacity pump; wound healing.

P1643 Thompson,J.S., Saxena,S.K., Greaton,C., Schultz,G., Sharp,J.G. The effect of the route of delivery of urogastrone on intestinal regeneration. Surgery 1989; 106(-1-):45-51. >>> Epidermal growth factor; Urogastrone; Saline; intestine (ileum); IV (vena cava); SC; rabbit; 2ML1; 7 days; functionality of mp verified by blood levels; dose-response; peptides; tissue perfusion.

top of page

2. Epidermal Growth Factor

15859 Mingfeng Zhang, Qing Lina,, Tong Qi, Tiankun Wang, Ching-Cheng Chen, Arthur D. Riggsa,, Defu Zeng. Growth factors and medium hyperglycemia induceSox9+ ductal cell differentiation intoǞcells inmice with reversal of diabetes. pnas 2016; 113(-3-):650-655. >>> Gastrin; epidermal growth factor, human recombinant; Acetic acid; PBS; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, WT or Ins1 CreERT); diabetes; Dose (gastrin 3 ug/kg/hr; EGF 10 ug/kg/hr);.

14699 Clausen, F., Lindh, T., Salimi, S., Erlandsson, A., Erlandsson, A. Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration. Brain Research 2014; 1588(--):37-46. >>> Epidermal growth factor, recombinant human; CSF/CNS; Rat; 2001; Controls received mp w/ saline or no mp w/ sham surgery; animal info (male, Sprague Dawley, 330-400g); ALZET brain infusion kit 2 used; behavioral testing (morris water maze); pumps removed after 7 days; traumatic brain injury;.

14655 Alluin, O., ivet-Mongrain, H., Gauthier, M.K., Fehlings, M.G., Rossignol, S., Karimi-Abdolrezaee, S., Karimi-Abdolrezaee, S. Examination of the Combined Effects of Chondroitinase ABC, Growth Factors and Locomotor Training following Compressive Spinal Cord Injury on Neuroanatomical Plasticity and Kinematics. PLoS One 2014; 9(--):U603-U621. >>> Chondroitinase ABC; platelet-derived growth factor-AA; basic fibroblast growth factor; epidermal growth factor;; Saline; rat serum albumin; CSF/CNS (intrathecal); Rat; 1007D; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 250-275g); spinal cord injury; behavioral testing (treadmill locomotion; coordination); used ALZET rat intrathecal catheter;.

13818 Jeffers, M.S., Hoyles, A., Morshead, C., Corbett, D., Corbett, D. Epidermal Growth Factor and Erythropoietin Infusion Accelerate Functional Recovery in Combination With Rehabilitation. Stroke 2014; 45(--):185-+. >>> Epidermal Growth Factor; erythropoietin; Cerebrospinal fluid, artificial; CSF/CNS; Rat; 2001; Animal info (male, Sprague Dawley); pumps replaced every 7 days; ischemia (cerebral); behavioral testing (staircase test); pumps removed 7 days after serial implantation;.

13781 Giachino, C., Basak, O., Lugert, S., Knuckles, P., Obernier, K., Fiorelli, R., Frank, S., Raineteau, O., varez-Buylla, A., Taylor, V., Taylor, V. Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population. Stem Cells 2014; 32(--):70-84. >>> Epidermal growth factor, human recombinant; Saline; BSA; CSF/CNS; Mice (transgenic); 1007D; Controls received mp w/ vehicle; animal info (Hes5::GFP, 2-3 months old); ALZET brain infusion kit 3 used; 0.1% BSA used;.

13585 Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stange, G., Shemer, R., Nord, C., Scheel, D.W., Pan, F.C., Ahlgren, U., Gu, G.Q., Stoffers, D.A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C.V.E., Van de Casteele, M., German, M.S., Bouwens, L., Heimberg, H. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. NATURE BIOTECHNOLOGY 2014; 32(-1-):76-+. >>> Epidermal growth factor, human recombinant; ciliary neurotrophic factor, human recombinant; Acetic acid; IP; Mice; 1007D; Controls received mp w/ vehicle; animal info (ALX35d, 13 weeks old, hyperglycemic); diabetes; ciliary neurotrophic factor aka CNTF; Epidermal growth factor aka EGF;.

13569 Wang, Y.F., Cooke, M.J., Sachewsky, N., Morshead, C.M., Shoichet, M.S. Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. JOURNAL OF CONTROLLED RELEASE 2013; 172(-1-):1-11. >>> Epidermal growth factor; erythropoietin; Cerebrospinal fluid, artificial; CSF/CNS; Mice; 1007D; Animal info (male, C57BL6, 9-11 weeks old); EGF-PGF pumps replaced after 7 days with pump filled with ETO; ALZET brain infusion kit 3 used; comparison of epicortical composite vs mp; stress/adverse reaction:"Unlike the ICV catheter/minipump,which causes significant tissue damage, the epicortical composite provides a minimal invasiveness and no tissue damage."(see pg.9); immunology; Pumps implanted 4 days after stroke; BIK implanted same day as stroke;.

top of page

3. Fibroblast Growth Factor

16166 Rhee, Y. H., Yi, S. H., Kim, J. Y., Chang, M. Y., Jo, A. Y., Kim, J., Park, C. H., Cho, J. Y., Choi, Y. J., Sun, W., Lee, S. H. Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. Sci Rep 2016; 6(--):32025. >>> Raf-Transducer cells, conditioned media; leukemia inhibitory factor; fibroblast growth factor 2; vascular endothelial growth factor; CSF, artificial; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle or control media; animal info (male, C57Bl6, 50-100g); ALZET brain infusion kit 2 used; immunology; cyanoacrylate adhesive; Brain coordinates;.

15215 Hawryluk, G.W.J., Spano, S., Chew, D., Wang, S., Erwin, M., Chamankhah, M., Forgione, N., Fehlings, M.G. An Examination of the Mechanisms by Which Neural Precursors Augment Recovery Following Spinal Cord Injury: A Key Role for Remyelination. CELL TRANSPLANTATION 2014; 23(-3-):365-380. >>> Epithelial growth factor; fibroblast growth factor; platelet-derived growth factor; CSF/CNS (intrathecal); Rat; 1007D; Animal info (female, Wistar, 10-12 weeks old); spinal cord injury; post op. care (bladders manually evacuated TID, Minocycline 50 mg/kg 10 days, cyclosporine 10 mg/kg); behavioral testing (open field test); immunology;.

15189 Patel, R., Bookout, A.L., Magomedova, L., Owen, B.M., Consiglio, G.P., Shimizu, M., Zhang, Y., Mangelsdorf, D.J., Kliewer, S.A., Cummins, C.L., Cummins, C.L. Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop. MOLECULAR ENDOCRINOLOGY 2015; 29(--):213-223. >>> Fibroblast growth factor 21; SC; Mice; Animal info (male, Fgf21 -/-);.

15069 Samms, R.J., Smith, D.P., Cheng, C.C., Antonellis, P.P., Perfield, JW II, Kharitonenkov, A., Gimeno, R.E., Adams, A.C., Adams, A.C. Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1. CELL REPORT 2015; 11(--):991-999. >>> Fibroblast growth factor 21, human; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6, 10 weeks old);.

15258 Lin, R.H., Cai, J.L., Nathan, C., Wei, X.T., Schleidt, S., Rosenwasser, R., Iacovitti, L., Iacovitti, L. Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. NEUROBIOLOGY OF DISEASE 2015; 74(--):229-239. >>> Basic fibroblast growth factor, recominant human; CSF, artificial; CSF/CNS; Rat; Animal info (male, Sprague Dawley, adult, 275-300g, MCAO); ischemia (cerebral); cardiovascular;.

14850 Boparai, R.K., Arum, O., Miquet, J.G., Masternak, M.M., Bartke, A., Khardori, R.K., Arum, O. Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2015; ;(--):U1-U11. >>> Fibroblast growth factor 21, human recombinant; PBS; SC; Mice (transgenic); 1007D; Controls received mp w/ vehicle; animal info (male, transgenic overexpress bovine growth hormone, 3-4 months old); diabetes;.

14844 Bernardo, B., Lu, M., Bandyopadhyay, G., Li, P.P., Zhou, Y.J., Huang, J., Levin, N., Tomas, E.M., Calle, R.A., Erion, D.M., Rolph, T.P., Brenner, M., Talukdar, S., Talukdar, S. FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. SCIENTIFIC REPORTS 2015; 5(--):U1-U13. >>> Fibroblast growth factor 21; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, DIO, 16, 21, or 32 weeks old); diabetes;.

top of page

4. Hepatocyte Growth Factor

12780 Katz, M.S., Thatch, K.A., Schwartz, M.Z. Gene alterations and intestinal mucosal changes following growth factor and omega-3 exposure in a rat model of inflammatory bowel disease. Journal of Pediatric Surgery 2013; 48(-2-):345-352. >>> Hepatocyte growth factor; HCl, Tris-; PBS; IV (jugular); Rat; Control animals received mp w/ saline; animal info (adult, female, tg, HLA-B27).

12391 Kitamura, K., Fujiyoshi, K., Yamane, J., Toyota, F., Hikishima, K., Nomura, T., Funakoshi, H., Nakamura, T., Aoki, M., Toyama, Y., Okano, H., Nakamura, M. Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury. PLoS One 2011; 6(-11-):U83-U95. >>> Hepatocyte growth factor, recomb. human; PBS; CSF/CNS (intrathecal); Monkey (marmoset); 2004; Controls received mp w/ vehicle; animal info (adult, female, common, 295-350 g); ALZET rat intrathecal catheter used.

12156 Katz, M.S., Thatch, K.A., Schwartz, M.Z. Hepatocyte growth factor and omega-3-enriched feeds have a synergistic effect on mucosal mass in an animal model of inflammatory bowel disease. Journal of Pediatric Surgery 2012; 47(-1-):194-198. >>> Hepatocyte growth factor, human recomb.; PBS; HCL, tris; IV (jugular); Rat; 2002; Controls received mp w/ saline; animal info (female, adult, HLA-B27, 200-250 g).

11832 Katz, M.S., Thatch, K.A., Schwartz, M.Z. Dose Variation of Hepatocyte Growth Factor and its Effects on an Animal Model of TPN-Induced Liver Injury. Journal of Surgical Research 2010; 163(-2-):294-298. >>> Hepatocyte growth factor; IV (jugular); Rat; Controls received mp w/ saline; animal info (Sprague Dawley, female, adult); dose response.

top of page

5. Insulin-like Growth Factor

15986 Ikemoto-Uezumi, M., Uezumi, A., Tsuchida, K., Fukada, S., Yamamoto, H., Yamamoto, N., Shiomi, K., Hashimoto, N. Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration. Stem Cells 2015; 33(-8-):2456-68. >>> Insulin-like growth factor II, pro; PBS; SC; Mice; 1003D; 2001; Controls received mp w/ vehicle; animal info (C57BL6, 2 months or 24-27 months old); Dose (0.5 ug/hr);.

15744 Jayne C. Charnock,, Mark R. Dilworth,, John D. Aplin,, Colin P. Sibley,, Melissa Westwood,, and Ian P. Crocker. The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. Am J Physiol Endocrinol Metab 2016; (-310-):E24-E31. >>> Insulin-like growth factor 2, Leu27; HCl; SC; SC; Controls received mp w/ vehicle; animal info (female, eNOS -/-, E12.5); teratology; Dose (1 mg/kg/day); noted using"100ul miniosmotic pump (200D)"pgE25;.

15720 Shameena Bake,, Andre K. Okoreeh,, Robert C. Alaniz,, and Farida Sohrabji. Insulin-Like Growth Factor (IGF)-I Modulates Endothelial Blood-Brain Barrier Function in Ischemic Middle-Aged Female Rats. Endocrinology 2016; (-157-):61-69. >>> Insulin-like growth factor-I, human recombinant; CSF, artificial; SC; Rat; 1003D; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 9-11 months old); animal info (female, Sprague Dawley, 9-11 months old); animal info (female, Sprague Dawley, 9-11 months old); immunology; cyanoacrylate adhesive; pumps primed overnight;.

15122 Van Landeghem, L., Santoro, M.A., Mah, A.T., Krebs, A.E., Dehmer, J.J., McNaughton, K.K., Helmrath, M.A., Magness, S.T., Lund, P.K., Lund, P.K. IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB JOURNAL 2015; 29(--):2828-2842. >>> Insulin-like growth factor, recombinant human; NaCl; SC; Mice; Controls received mp w/ vehicle; animal info (Sox9-EGFP);.

15088 Standen, P., Sferruzzi-Perri, A.N., Taylor, R., Heinemann, G., Zhang, J.V., Highet, A.R., Pringle, K.G., Owens, J.A., Kumarasamy, V., Lumbers, E.R., Roberts, C.T., Roberts, C.T. Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig. GROWTH HORMONE&IGF RESEARCH 2015; 25(--):141-147. >>> Insulin-like growth factor-1; insulin-like growth factor 2; Acetic acid; SC; Guinea Pig; 2002; Controls received mp w/ vehicle; animal info (GD20); teratology; cardiovascular;.

15050 Mysoet, J., Dupont, E., Bastide, B., Canu, M.H., Canu, M.H. role of IGF-1 in cortical plasticity and functional deficit induced by sensorimotor restriction. BEHAVIOURAL BRAIN RESEARCH 2015; 290(--):117-123. >>> Insulin-like growth factor-1; CSF, artificial; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Wistar, 280-320g); behavioral testing (mechanical withdrawal); pumps primed overnight;.

14776 Simmons, A.J., Banerjee, A., McKinley, E.T., Scurrah, C.R., Herring, C.A., Gewin, L.S., Masuzaki, R., Karp, S.J., Franklin, J.L., Gerdes, M.J., Irish, J.M., Coffey, R.J., Lau, K.S., Lau, K.S. Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-alpha-induced apoptosis in vivo. Molecular Systems Biology 2015; 11(--):U60-U73. >>> Insulin-like growth factor-1, human, recomb.; Water; Mice; animal info (female, C57BL/6).

14421 Sundstroem, K., Cedervall, T., Ohlsson, C., Camacho-Huebner, C., Saevendahl, L., Sundstroem, K. Combined Treatment With GH and IGF-I: Additive Effect on Cortical Bone Mass But Not on Linear Bone Growth in Female Rats. Endocrinology 2014; 155(--):4798-4807. >>> Insulin-like growth factor-1; NaCl; acetic acid; water, sterile, sodium acetate trihydrate; polysorbate 20; sodium citrate; citric acid monohydrate; phenol; SC; Rat; 1007D; 2001; Animal info (female, Wistar, 23 days old); functionality of mp verified by ELISA of serum; pumps replaced every week; stress/adverse reaction: (see pg. 4799 seroma); post op. care (bupivacaine 1 mg/kg, carprofen 5 mg/kg);"Problems with drug absorption could also have affected the results because many animals developed a seroma at the site of pump implantation, being most pronounced in animals treated with combination therapy. The seromas did not resolve and were first noted after 2 weeks of therapy. These could theoretically have affected the uptake of the drug into the circulation. However, when evaluating the growth rates of animals with seromas with group mates without seromas, no differences were observed."pg 4805-4806;.

14420 Sukhanov, S., Snarski, P., Vaughn, C., Lobelle-Rich, P., Kim, C., Higashi, Y., Shai, S.Y., Delafontaine, P., Sukhanov, S. Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase. Atherosclerosis 2015; 238(--):313-320. >>> Insulin-like growth factor-1, human recombinant; Mice; Controls received mp w/ saline; animal info (Apoe -/-, 8 weeks old); cardiovascular; immunology;.

top of page

6. Nerve Growth Factor

16152 Pereira, P. A., Rocha, J. P., Cardoso, A., Vilela, M., Sousa, S., Madeira, M. D. Effects of chronic alcohol consumption, withdrawal and nerve growth factor on neuropeptide Y expression and cholinergic innervation of the rat dentate hilus. Neurotoxicology 2016; 54(--):153-60. >>> Nerve growth factor; Methylene blue; BSA; CSF, artificial; CSF/CNS; Rat; 2002; animal info (male, Wistar); functionality of mp verified by residual volume; ALZET brain infusion kit used; post op. care (SC injections of 0.9% saline (2ml)); pulsed delivery; used PE-60 tubing; used lynch coil;.

15856 Yokomizo, A., Takatori, S., Hashikawa-Hobara, N., Goda, M., Kawasaki, H. Nerve growth factor facilitates redistribution of adrenergic and non-adrenergic non-cholinergic perivascular nerves injured by phenol in rat mesenteric resistance arteries. Eur J Pharmacol 2016; 770(--):110-6. >>> Nerve growth factor; Saline, sterile; IP; Rat; 1007D; animal info (Wistar, 8 weeks old); Dose (20 ug/kg/day);.

15757 Ciro De Luca, Leonilde Savarese, Anna Maria Colangelo, Maria Rosaria Bianco, Giovanni Cirillo, Lilia Alberghina, Michele Papa. Astrocytes and Microglia-Mediated Immune Response in Maladaptive Plasticity is Differently Modulated by NGF in the Ventral Horn of the Spinal Cord Following Peripheral Nerve Injury. Cell Mol Neurobiol 2016; (-36-):37-46. >>> Nerve growth factor, b-; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); Cannula placement verified via induced lower body paralysis (IT lidocane injection); spared nerve injury; Dose (12 ug/kg/day);.

15231 Schlachetzki, J.C.M., Pizzo, D.P., Morrissette, D.A., Winkler, J. Intracerebroventricular Administration of Nerve Growth Factor Induces Gliogenesis in Sensory Ganglia, Dorsal Root, and within the Dorsal Root Entry Zone. BIOMED RESEARCH INTERNATIONAL 2014; ;(-;-):U1-U9. >>> Nerve growth factor, human recombinant; Cytochrome C; CSF, artificial; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Fischer 344 albino, 281.8 +/- 2g); used Plastics One cannula;.

14883 Chen, W.H., Mao, C.Q., Zhuo, L.L., Ong, J.L., Chen, W.H. Beta-nerve growth factor promotes neurogenesis and angiogenesis during the repair of bone defects. Neural Regeneration Research 2015; 10(--):1159-1165. >>> Nerve growth factor, b-; PBS; Evans blue dye; Bone (parietal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 250-300g); 1% Evans blue used; good methods (picture of dual cannula impmlantation pg 1161); Multiple pumps per animal (2); pump with agent inserted into right pocket, pump with PBS inserted into left pocket; bilateral infusion;.

14261 Lee, J.Y., Jahng, J.W., Kim, S.M., Kim, M.J., Lee, J.H., Lee, J.H. Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study. Journal of Oral and Maxillofacial Surgery 2015; 73(--):410-423. >>> Nerve growth factor, human B-; PBS; CSF/CNS (inferior alveolar nerve); Dog (beagle); 2ML2; Controls received mp w/ vehicle; animal info (male, beagle, 18 weeks old, 10-12 kg); good methods (picture of implant pg 413); Multiple pumps per animal (2; one pump delivered NGF other delivered PBS); used rat jugular catheter, 15 cm long; pump body placed into retromandibular area; long-term study;.

14605 Pereira, P.A., Neves, J., Vilela, M., Sousa, S., Cruz, C., Madeira, M.D., Pereira, P.A. Chronic alcohol consumption leads to neurochemical changes in the nucleus accumbens that are not fully reversed by withdrawal. NEUROTOXICOLOGY AND TERATOLOGY 2014; 44(--):53-61. >>> Nerve growth factor; CSF, artificial; methylene blue; CSF/CNS; Rat; 2002; Control animals received mp w/ vehicle; animal info (male, Wistar); Lynch coil; PE60 tubing used; ALZET brain infusion kit used;"The cannulae were connected to methylene blue... filled Alzet osmotic minipumps... via sterile coiled polyethylene tubing... This tubing was filled with air-oil spacer at the pump end and with NGF."pg 54; pump functionality verified via residual volume.

14598 Shaqura, M., Khalefa, B.I., Shakibaei, M., Zoellner, C., Al-Khrasani, M., Fuerst, S., Schaefer, M., Mousa, S.A., Mousa, S.A. New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy. Neuropharmacology 2014; 85(--):142-150. >>> Nerve growth factor, beta; albumin, rat serum; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; Control animals received mp w/ animal info (male, Wistar, STZ induced diabetes).

13950 Yegla, B., Parikh, V. EFFECTS OF SUSTAINED PRONGF BLOCKADE ON ATTENTIONAL CAPACITIES IN AGED RATS WITH COMPROMISED CHOLINERGIC SYSTEM. Neuroscience 2014; 261(-;-):118-132. >>> Antibody, pro-nerve growth factor; PBS; CSF/CNS; Rat; 1004; Controls received mp w/ vehicle; animal info (male, Wistar, 23 months old); ALZET brain infusion kit used; good methods (cannula placement pg.124, fig.2); post op. care (triple antibiotic cream on wound; Baytril injected; buprenorphine); behavioral testing (sustained attention task, performance measures); Cannula placement verified via Nissl staining; used dental cement and bone screws; pumps and cannula removed after 4 weeks;.

13586 Birch, A.M., Kelly, A.M. Chronic intracerebroventricular infusion of nerve growth factor improves recognition memory in the rat. Neuropharmacology 2013; 75(-;-):255-261. >>> Nerve growth factor, b-; Cerebrospinal fluid, artificial; CSF/CNS; Rat; Controls received mp w/ vehicle or no surgery; animal info (Male, wistar, 250-300g); functionality of mp verified by analysis of NGF concentration in brain; behavioral testing (object recognition memory); long-term study;.

13507 Tomioka, T., Shimazaki, T., Yamauchi, T., Oki, T., Ohgoh, M., Okano, H. LIM Homeobox 8 (Lhx8) Is a Key Regulator of the Cholinergic Neuronal Function via a Tropomyosin Receptor Kinase A (TrkA)-mediated Positive Feedback Loop. Journal of Biological Chemistry 2014; 289(-2-):1000-1010. >>> Nerve growth factor, murine; PBS; CSF/CNS; Rat; 2001; Control animals received mp w/ vehicle; animal info (adult, male, Sprague Dawley, 8 wks old); ALZET brain infusion kit 2 used.

top of page

7. Placental Growth Factor

15845 MingWu, Piet Claus, Nina Vanden Driessche, Geert Reyns, Peter Pokreisz, Hilde Gillijns, Ellen Caluwe, Jan Bogaert, Desire Collen, Stefan Janssens. Placental growth factor 2— A potential therapeutic strategy for chronic myocardial ischemia. International Journal of Cardiology 2016; 203(--):534-542. >>> Placental growth factor-2, recombinant human; PBS; IV; Pig; 2ML2; Controls received mp w/ vehicle; animal info (Sus Scrofa, 20-25kg); functionality of mp verified by plasma levels; ischemia (myocardial); cardiovascular; Dose (15 ug/kg/day);.

14268 Li, J., Ying, H.C., Cai, G.Y., Guo, Q., Chen, L.Z., Li, J. Impaired proliferation of pancreatic beta cells, by reduced placental growth factor in pre-eclampsia, as a cause for gestational diabetes mellitus. Cell Proliferation 2015; 48(--):166-174. >>> Placental growth factor, human; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (female, Balb/c, GD9); functionality of mp verified by plasma levels; cardiovascular; bp measured using tail cuff;.

10739 Takeda, Y., Uemura, S., Iwama, H., Imagawa, K.I., Nishida, T., Onoue, K., Takemoto, Y., Soeda, T., Okayama, S., Somekawa, S., Ishigami, K.I., Takaoka, M., Kawata, H., Kubo, A., Horii, M., Nakajima, T., Saito, Y. Treatment With Recombinant Placental Growth Factor (PIGF) Enhances Both Angiogenesis and Arteriogenesis and Improves Survival After Myocardial Infarction. CIRCULATION JOURNAL 2009; 73(-9-):1674-1682. >>> Placental growth factor, recomb. human; flt-1, recomb. human, soluble; IP; Mice; Controls received mp w/ vehicle; animal info (C57BL/6, 12 wks old); polyethylene IP catheter used.

7322 Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., De Mol, M., Wu, Y., Bono, F., Devy, L., Beck, H., Scholz, D., Ackerk, T., DiPalma, T., Dewerchin, M., Noel, A., Stalmans, I., Barra, A., Blacher, S., VandenDriessche, T., Ponten, A., Eriksson, U., Plate, K.H., Foidart, J.M., Schaper, W., Charnock-Jones, S., Hicklin, D.J., Herbert, J.M., Collen, D., Persico, M.G. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nature Medicine 2001; 7(-5-):575-583. >>> Placental growth factor-1, recomb. human; Mice; 2001; Controls received mp w/ vehicle; replacement therapy (PgF -/- mice); cardiovascular; ischemia (retinal); embryology.

6900 Tamarat, R., Silvestre, J.S., Ricousse-Roussanne, S., Barateau, V., Lecomte-Raclet, L., Clergue, M., Duriez, M., Tobelem, G., Levy, B.I. Impairment in ischemia-induced neovascularization in diabetes - Bone marrow mononuclear cell dysfunction and therapeutic potential of placenta growth factor treatment. American Journal of Pathology 2004; 164(-2-):457-466. >>> Placental growth factor; SC; Mice; 2001; Diabetes, placenta growth factor (PIGF) is a VEGF homologue; ischemia.

6128 Luttun, A., Tjwa, M., Moons, L., Wu, Y., Angelillo-Scherrer, A., Liao, F., Nagy, J.A., Hooper, A., Priller, J., De Klerck, B., Compernolle, V., Daci, E., Bohlen, P., Dewerchin, M., Herbert, J.M., Fava, R., Matthys, P., Carmeliet, G., Collen, D., Dvorak, H.F., Hicklin, D.J., Carmeliet, P. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nature Medicine 2002; 8(-8-):831-840. >>> Placental growth factor; vascular endothelial growth factor; SC; Mice; 2001; Angiogenesis.

5801 Pipp, F., Heil, M., Issbrucker, K., Ziegelhoeffer, T., Martin, S., van den Heuvel, J., Weich, H., Fernandez, B., Golomb, G., Carmeliet, P., Schaper, W., Clauss, M. VEGFR-1-selective VEGF homologue PlGF is arteriogenic - Evidence for a monocyte-mediated mechanism. Circulation Research 2003; 92(-4-):378-385. >>> Vascular endothelial growth factor; Vascular endothelial growth factor-E; Monocyte chemoattractant protein-1; Placental growth factor; Phosphate buffer; albumin; IA (femoral); Mice; rabbit; Controls received mp w/ vehicle; dose-response (p.381); peptides; placenta growth factor (PlGF) is a VEGF homologue; VEGF-E is a chimera containing the heparin-binding domain of VEGF; MCP-1.

top of page

8. Transforming Growth Factor

14329 Okizaki, S., Ito, Y., Hosono, K., Oba, K., Ohkubo, H., Amano, H., Shichiri, M., Majima, M., Majima, M. Suppressed recruitment of alternatively activated macrophages reduces TGF-beta1 and impairs wound healing in streptozotocin-induced diabetic mice. BIOMEDICINE&PHARMACOTHERAPY 2015; 70(--):317-325. >>> Transforming growth factor-B1; PBS; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57Bl6, 8 weeks old, diabetes induced STZ); immunology; diabetes;.

13843 Lantero, A., Tramullas, M., Pilar-Cuellar, F., Valdizan, E., Santillan, R., Roques, B.P., Hurle, M.A., Hurle, M.A. TGF-beta and Opioid Receptor Signaling Crosstalk Results in Improvement of Endogenous and Exogenous Opioid Analgesia under Pathological Pain Conditions. Journal of Neuroscience 2014; 34(--):5385-5395. >>> Transforming growth factor-B1; HCl; albumin; SC; Mice (transgenic); 1002; Controls received mp w/ vehicle; animal info (male, BAMBI-KO or WT, 14-18 weeks old); behavioral testing (von Frey monofiliments; formalin test); Transforming growth factor-B1 aka TGF-B1; sciatic nerve crush injury;.

12613 Chim, H., Miller, E., Gliniak, C., Alsberg, E. Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-beta1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding. Cell and Tissue Research 2012; 350(-1-):89-94. >>> Stromal-cell-derived factor-1, alpha; bone morphogenic protein 2; transforming growth factor-1, beta; IP (abdominal wall); Rat; 2004; Negative control animals received no cytokines; animal info (Sprague Dawley, adult);"A custom-made apparatus for the constant delivery of cytokines was assembled consisting in a microneedle system and Alzet osmotic pump"pg 90; fig 1b, image of custom-made cytokine delivery apparatus; tissue perfusion (anterior abdominal wall).

12610 Holmberg, C., Quante, M., Steele, I., Kumar, J.D., Balabanova, S., Duval, C., Czepan, M., Rakonczay, Z.Jr, Tiszlavicz, L., Nemeth, I., Lazar, G., Simonka, Z., Jenkins, R., Hegyi, P., Wang, T.C., Dockray, G.J., Varro, A. Release of TGF beta ig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression. Carcinogenesis 2012; 33(-8-):1553-1562. >>> Transforming growth factor-beta-induced gene h3; Mice (SCID); Animal info (SCID, 6-8 wks old); cancer.

top of page

9. Vascular Endothelial Growth Factor

16221 Oller, J., Alfranca, A., Mendez-Barbero, N., Villahoz, S., Lozano-Vidal, N., Martin-Alonso, M., Arroyo, A. G., Escolano, A., Armesilla, A. L., Campanero, M. R., Redondo, J. M. C/EBPbeta and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol 2015; 35(-19-):3409-22. >>> Vascular Endothelial Growth Factor, Angiotensin II, Losartan, Cyclosporine; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (Calcineurin (CN) B1 (Cnb1_/fl) conditional knockout mice, C57BL/6 mice); dose-response; vegf aka vascular endothelial growth factor; Dose (VEGF 25 ug/kg/day, AngII 1 ug/kg/min, CsA 5 mg/kg/day, Losartan 10 mg/kg/day);.

16166 Rhee, Y. H., Yi, S. H., Kim, J. Y., Chang, M. Y., Jo, A. Y., Kim, J., Park, C. H., Cho, J. Y., Choi, Y. J., Sun, W., Lee, S. H. Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. Sci Rep 2016; 6(--):32025. >>> Raf-Transducer cells, conditioned media; leukemia inhibitory factor; fibroblast growth factor 2; vascular endothelial growth factor; CSF, artificial; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle or control media; animal info (male, C57Bl6, 50-100g); ALZET brain infusion kit 2 used; immunology; cyanoacrylate adhesive; Brain coordinates;.

15103 Taylor, S.L., Trudeau, D., Arnold, B., Wang, J.S., Gerrow, K., Summerfeldt, K., Holmes, A., Zamani, A., Brocardo, P.S., Brown, C.E., Brown, C.E. VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes. NEUROBIOLOGY OF DISEASE 2015; 78(--):1-11. >>> Vascular endothelial growth factor (165); CSF, artificial; CSF/CNS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, C57BL6J, 2 months old); ALZET brain infusion kit 3 used; behavioral testing (Morris water maze); diabetes;.

14689 Chehrehasa, F., Cobcroft, M., Young, Y.W., kay-Sim, A., Goss, B., kay-Sim, A. An Acute Growth Factor Treatment that Preserves Function after Spinal Cord Contusion Injury. Journal of Neurotrauma 2014; 31(--):1807-1813. >>> Vascular endothelial growth factor; platelet-derived growth factor-BB; PBS; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ saline; animal info (female, Wistar, 20-25 weeks, 300g); spinal cord injury; post op. care (cephalothin; buprenorphine; manual bowel and bladder expression BID); behavioral testing (locomotor behavior; gaid and footprint analysis); used Rat intrathecal catheter; pumps primed in 37C saline overnight;.

13648 Lassaletta, A.D., Elmadhun, N.Y., Burgess, T.A., Bianchi, C., Sabe, A.A., Robich, M.P., Chu, L.M., Sellke, F.W. Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. CIRCULATION JOURNAL 2014; 78(-3-):743-751. >>> Vascular endothelial growth factor, recombinant human; Heparin; Saline; Intrapericardial; Pig; 2ML4; Animal info (male, Yorkshire miniswine, 13-22kg); ischemia (cardiac, chronic); stress/adverse reaction: (see pg. 746); post op. care (Enrofloxacin 68mg PO daily for 5 days; aspirin 325 mg/day for 5 days; buprenorphine HCL 0.3 mg/kg, transdermal fentanyl patch 4mcg/kg for 72h); cardiovascular;.

13277 Shim, J.W., Sandlund, J., Han, C.H., Hameed, M.Q., Connors, S., Klagsbrun, M., Madsen, J.R., Irwin, N. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Experimental Neurology 2013; 247(-;-):703-709. >>> Vascular endothelial growth factor-A165; Bevacizumab; Saline; BSA; CSF/CNS; Rat; 2001D; Controls received mp w/vehicle, or (saline, BSA); Peptides; animal info (male Sprague-Dawley rats, 250g); Brain infusion kit (2) used;.

13167 Zechariah, A., ElAli, A., Doeppner, T.R., Jin, F.Y., Hasan, M.R., Helfrich, I., Mies, G., Hermann, D.M. Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra. Stroke 2013; 44(-6-):1690-U393. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 2004; Controls received mp w/ saline; animal info (male C57BL6/j, 20-25g); ischemia.

13118 Wang, L., Wang, X., Wang, L., Chiu, J.D., van de Ven, G., Gaarde, W.A., DeLeve, L.D. Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells. Gastroenterology 2012; 143(-6-):1555-U239. >>> Vascular endothelial growth factor; IP; Rat; Animal info (Lewis, VEGF KO, hepatectomy); infusion rate of 1 ul/hr.

12897 Siddiqui, A.H., Irani, R.A., Zhang, W.R., Wang, W., Blackwell, S.C., Kellems, R.E., Xia, Y. Angiotensin Receptor Agonistic Autoantibody-Mediated Soluble Fms-Like Tyrosine Kinase-1 Induction Contributes to Impaired Adrenal Vasculature and Decreased Aldosterone Production in Preeclampsia. Hypertension 2013; 61(-2-):472-U526. >>> Vascular endothelial growth factor, 121; Mice (pregnant); Animal info (C57BL/6).

12879 Shan, L., Yong, H.M., Song, Q., Wei, Y., Qin, R., Zhang, G.H., Xu, M.Y., Zhang, S.H. Vascular endothelial growth factor B prevents the shift in the ocular dominance distribution of visual cortical neurons in monocularly deprived rats. Experimental Eye Research 2013; 109(-;-):17-21. >>> Vascular endothelial growth factor B; CSF, artificial; CSF/CNS; Rat; 1007D; Control animals received mp w/ vehicle; animal info (Long Evans hooded); PE60 tubing used.

12754 Xiao, X.W., Guo, P., Chen, Z., El-Gohary, Y., Wiersch, J., Gaffar, I., Prasadan, K., Shiota, C., Gittes, G.K. Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass. Journal of Biological Chemistry 2013; 288(-12-):8636-8646. >>> Vascular endothelial growth factor, A; Mice; 2004; Animal info (C57BL/6, MIP-GFP, male, 8 wks old);.

top of page

10. Vascular Endothelial Growth Factor

Q4609 Taylor,S.L., Trudeau,D., Arnold,B., Wang,J.S., Gerrow,K., Summerfeldt,K., Holmes,A., Zamani,A., Brocardo,P.S., Brown,C.E., Brown,C.E. VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes. NEUROBIOLOGY OF DISEASE 2015; 78(--):1-11. >>> Vascular endothelial growth factor (165); CSF, artificial; CSF/CNS; Mice; 2006; 8 weeks; Controls received mp w/ vehicle; animal info (male, C57BL6J, 2 months old); ALZET brain infusion kit 3 used; behavioral testing (Morris water maze); diabetes;.

Q3833 Chehrehasa,F., Cobcroft,M., Young,Y.W., kay-Sim,A., Goss,B., kay-Sim,A. An Acute Growth Factor Treatment that Preserves Function after Spinal Cord Contusion Injury. Journal of Neurotrauma 2014; 31(--):1807-1813. >>> Vascular endothelial growth factor; platelet-derived growth factor-BB; PBS; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ saline; animal info (female, Wistar, 20-25 weeks, 300g); spinal cord injury; post op. care (cephalothin; buprenorphine; manual bowel and bladder expression BID); behavioral testing (locomotor behavior; gaid and footprint analysis); used Rat intrathecal catheter; pumps primed in 37C saline overnight;.

Q3348 Lassaletta,A.D., Elmadhun,N.Y., Burgess,T.A., Bianchi,C., Sabe,A.A., Robich,M.P., Chu,L.M., Sellke,F.W. Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. CIRCULATION JOURNAL 2014; 78(-3-):743-751. >>> Vascular endothelial growth factor, recombinant human; Heparin; Saline; Intrapericardial; Pig; 2ML4; 4 weeks; Animal info (male, Yorkshire miniswine, 13-22kg); ischemia (cardiac, chronic); stress/adverse reaction: (see pg. 746); post op. care (Enrofloxacin 68mg PO daily for 5 days; aspirin 325 mg/day for 5 days; buprenorphine HCL 0.3 mg/kg, transdermal fentanyl patch 4mcg/kg for 72h); cardiovascular;.

Q2990 Shim,J.W., Sandlund,J., Han,C.H., Hameed,M.Q., Connors,S., Klagsbrun,M., Madsen,J.R., Irwin,N. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Experimental Neurology 2013; 247(-;-):703-709. >>> Vascular endothelial growth factor-A165; Bevacizumab; Saline; BSA; CSF/CNS; Rat; 2001D; 1 day; Controls received mp w/vehicle, or (saline, BSA); Peptides; animal info (male Sprague-Dawley rats, 250g); Brain infusion kit (2) used;.

Q2881 Zechariah,A., ElAli,A., Doeppner,T.R., Jin,F.Y., Hasan,M.R., Helfrich,I., Mies,G., Hermann,D.M. Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra. Stroke 2013; 44(-6-):1690-U393. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 2004; 3, 10 days; Controls received mp w/ saline; animal info (male C57BL6/j, 20-25g); ischemia.

Q2833 Wang,L., Wang,X., Wang,L., Chiu,J.D., van de Ven,G., Gaarde,W.A., DeLeve,L.D. Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells. Gastroenterology 2012; 143(-6-):1555-U239. >>> Vascular endothelial growth factor; IP; Rat; ; Animal info (Lewis, VEGF KO, hepatectomy); infusion rate of 1 ul/hr.

Q2611 Siddiqui,A.H., Irani,R.A., Zhang,W.R., Wang,W., Blackwell,S.C., Kellems,R.E., Xia,Y. Angiotensin Receptor Agonistic Autoantibody-Mediated Soluble Fms-Like Tyrosine Kinase-1 Induction Contributes to Impaired Adrenal Vasculature and Decreased Aldosterone Production in Preeclampsia. Hypertension 2013; 61(-2-):472-U526. >>> Vascular endothelial growth factor, 121; Mice (pregnant); 5 days; Animal info (C57BL/6).

Q2593 Shan,L., Yong,H.M., Song,Q., Wei,Y., Qin,R., Zhang,G.H., Xu,M.Y., Zhang,S.H. Vascular endothelial growth factor B prevents the shift in the ocular dominance distribution of visual cortical neurons in monocularly deprived rats. Experimental Eye Research 2013; 109(-;-):17-21. >>> Vascular endothelial growth factor B; CSF, artificial; CSF/CNS; Rat; 1007D; ; Control animals received mp w/ vehicle; animal info (Long Evans hooded); PE60 tubing used.

Q2468 Xiao,X.W., Guo,P., Chen,Z., El-Gohary,Y., Wiersch,J., Gaffar,I., Prasadan,K., Shiota,C., Gittes,G.K. Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass. Journal of Biological Chemistry 2013; 288(-12-):8636-8646. >>> Vascular endothelial growth factor, A; Mice; 2004; ; Animal info (C57BL/6, MIP-GFP, male, 8 wks old);.

Q2316 Argandona,E.G., Bengoetxea,H., Bulnes,S., Rico-Barrio,I., Ortuzar,N., Lafuente,J.V. Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex. Brain Research 2012; 1473(-;-):141-154. >>> Vascular endothelial growth factor; anti-VEGF; PBS; CSF/CNS (cortex); Rat; 1007D; ; Control animals received mp w/ vehicle; animal info (Long Evans, P18); ALZET brain infusion kit used; cyanoacrylate adhesive used.

Q2201 Mateus,J., Bytautiene,E., Lu,F.X., Tamayo,E.H., Betancourt,A., Hankins,G.D.V., Longo,M., Saade,G.R. Endothelial growth factor therapy improves preeclampsia-like manifestations in a murine model induced by overexpression of sVEGFR-1. American Journal of Physiology-Heart and Circulatory Physiology 2011; 301(-5-):H1781-H1787. >>> Vascular endothelial growth factor 121; PBS; SC; Mice (pregnant); 2002; 10 days; Controls received mp w/ vehicle; animal info (CD-1); functionality of mp verified by residual volume and plasma drug levels.

Q1819 Thau-Zuchman,O., Shohami,E., Alexandrovich,A.G., Leker,R.R. SUBACUTE TREATMENT WITH VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER TRAUMATIC BRAIN INJURY INCREASES ANGIOGENESIS AND GLIOGENESIS. Neuroscience 2012; 202(-;-):334-341. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 7 days; Controls received mp w/ vehicle; animal info (adult, Sabra, 40 g).

Q1810 Herz,J., Reitmeir,R., Hagen,S.I., Reinboth,B.S., Guo,Z.Y., Zechariah,A., ElAli,A., Doeppner,T.R., Bacigaluppi,M., Pluchino,S., Kilic,U., Kilic,E., Hermann,D.M. Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions. NEUROBIOLOGY OF DISEASE 2012; 45(-3-):1077-1085. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS; Mice; 2002; 2004; 4 weeks; Controls received mp w/ saline; animal info (male, C57BL/6J, 8-10 wks old, 23-25 g); ischemia.

Q1775 Lutton,C., Young,Y.W., Williams,R., Meedeniya,A.C.B., kay-Sim,A., Goss,B. Combined VEGF and PDGF Treatment Reduces Secondary Degeneration after Spinal Cord Injury. Journal of Neurotrauma 2012; 29(-5-):957-U479. >>> Vascular endothelial growth factor; platelet-derived growth factor; Saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (Wistar, male, adult, 300 g, 20-25 wks old); functionality of mp verified in vitro; "catheter was... sutured to the muscle to keep it in place" pg 959.

Q1664 Chu,L.M., Robich,M.P., Lassaletta,A.D., Feng,J., Laham,R.J., Burgess,T., Clements,R.T., Sellke,F.W. Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia. Surgery 2011; 150(-3-):390-399. >>> Vascular endothelial growth factor, recomb. human; Intrapericardial; Pig; ; Animal info (intact, male, Yorkshire); stress/adverse effects "sudden cardiac death", pg 393.

Q1655 Thau-Zuchman,O., Shohami,E., Alexandrovich,A.G., Leker,R.R. Combination of Vascular Endothelial and Fibroblast Growth Factor 2 for Induction of Neurogenesis and Angiogenesis after Traumatic Brain Injury. Journal of Molecular Neuroscience 2012; 47(-1-):166-172. >>> Vascular endothelial growth factor; Saline; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, Sabra, adult, 40 g).

Q1620 Reitmeir,R., Kilic,E., Reinboth,B.S., Guo,Z.Y., ElAli,A., Zechariah,A., Kilic,U., Hermann,D.M. Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain. Acta Neuropathologica 2012; 123(-2-):273-284. >>> Vascular endothelial growth factor; NaCl; CSF/CNS; Mice; 2002; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (male, C57Bl6/j, 8-10 wks old, 23-25 g); ischemia (MCAO); stress/adverse effects, "complications related to pump insertion" pg 274; behavioral testing (Rotarod, grip strength test).

Q1592 Romo,L.B., Tapia,R. VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK. Journal of Neurochemistry 2010; 115(-5-):1090-1101. >>> Isoxazolepropionate, alpha amino-3-hydroxy-5-; vascular endothelial growth factor, recomb., 164; SU14980, tyrphostin; LY294002; wortmannin; PD-98059; SB203580; neurodegenerative (amyotrophic lateral sclerosis);; PBS; DMSO; CSF/CNS (intrathecal, spinal cord); Rat; 2004; 2, 10, 20 days; Controls received mp w/ vehicle; animal info (Wistar, male, 270-290 g, adult); alpha amino-3-hydroxy-5-isoxazolepropionate also known as AMPA; wound clips used; post op. care, pg 1091 (penicillin); good methods, pg 1091; multiple pumps used (2); multiple intrathecal catheters used; wound clips used; 2% DMSO used; enzyme inhibitor (p38 mitogen-activated protein kinase, p38MAPK).

Q1355 Thau-Zuchman,O., Shohami,E., Alexandrovich,A.G., Leker,R.R. Vascular endothelial growth factor increases neurogenesis after traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism 2010; 30(-5-):1008-1016. >>> Vascular endothelial growth factor; CSF/CNS; Mice; 6, 7 days; Controls received mp w/ vehicle or were sham operated; animal info (adult, Sabra, male, 40 g); infusion rate of 0.5 ul/hr.

Q1347 Siddiqui,A.H., Irani,R.A., Zhang,Y.J., Dai,Y.B., Blackwell,S.C., Ramin,S.M., Kellems,R.E., Xia,Y. Recombinant Vascular Endothelial Growth Factor 121 Attenuates Autoantibody-Induced Features of Pre-eclampsia in Pregnant Mice. American Journal of Hypertension 2011; 24(-5-):606-612. >>> Vascular endothelial growth factor 121; SC; Mice (pregnant); 1007D; 5 days; Animal info (C57BL/6, 8 wks old).

Q1236 Miyasaka,E.A., Raghavan,S., Gilmont,R.R., Mittal,K., Somara,S., Bitar,K.N., Teitelbaum,D.H. In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival. PEDIATRIC SURGERY INTERNATIONAL 2011; 27(-2-):137-143. >>> Fibroblast growth factor-2; vascular endothelial growth factor-2; platelet-derived growth factor; SC; Mice; 1004; 28 days; Controls received mp with no growth factors; animal info (C57BL/6); good methods, pg 138; tissue perfusion (internal anal sphincter); silicone catheter used; "the osmotic pumps we used completed delivery of the growth factors by 28 days, which would clearly limit the duration of exposure to the growth factor, lessening the risk of malignancy" pg 143.

Q1197 Lee,C., Agoston,D.V. Vascular Endothelial Growth Factor Is Involved in Mediating Increased De Novo Hippocampal Neurogenesis in Response to Traumatic Brain Injury. Journal of Neurotrauma 2010; 27(-3-):541-553. >>> Vascular endothelial growth factor 164; SU5416; uridine, bromodeoxy; CSF, artificial; DMSO; CSF/CNS; Rat; 2002; 13 days; Controls received mp w/ vehicle; animal info (young, Sprague Dawley, male, 270-300 g); 1% DMSO used.

Q0878 Ortuzar,N., Argandona,E.G., Bengoetxea,H., Lafuente,J.V. Combination of intracortically administered VEGF and environmental enrichment enhances brain protection in developing rats. Journal of Neural Transmission 2011; 118(-1-):135-144. >>> Vascular endothelial growth factor; CSF/CNS (cortex); Rat; 1007D; 7 days; Controls received mp w/ PBS or no implantation; animal info (Long-Evans, P18); cyanoacrylate adhesive; ALZET brain infusion kit 3 used; "Total operating time was approximately 25 min." pg 137.

Q0712 Nicoletti,J.N., Lenzer,J., Salerni,E.A., Shah,S.K., Elkady,A., Khalid,S., Quinteros,D., Rotella,F., Betancourth,D., Croll,S.D. Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats. EPILEPSY&BEHAVIOR 2010; 19(-3-):272-277. >>> Vascular endothelial growth factor, 165, recomb. human; vascular endothelial growth factor, inactivated; PBS, sterile; CSF/CNS (hippocampus); Rat; 2002; 2 weeks; Controls received no surgical manipulations or protein infusions; animal info (male Sprague-Dawley, 250-350 g); behavioral testing (Morris water maze, Grid locomotor activity, Light-dark exploration).

Q0514 Lee,C., Agoston,D.V. Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury. Experimental Neurology 2009; 220(-2-):400-403. >>> Vascular endothelial growth factor (164); SU5416; CSF, artificial; DMSO; CSF/CNS; Rat; 1002; 13 days; Controls received mp w/ vehicle; animal info (young, male, Sprague Dawley, 270-330 g.); cannula placement verified by histology; 1% DMSO used; artificial CSF recipe.

Q0400 Bogaert,E., Van Damme,P., Poesen,K., Dhondt,J., Hersmus,N., Kiraly,D., Scheveneels,W., Robberecht,W., Van den Bosch,L. VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. NEUROBIOLOGY OF AGING 2010; 31(-12-):2185-2191. >>> Vascular endothelial growth factor; CSF/CNS; Rat; 2004; 1 week; Controls received mp w/ vehicle; animal info (80 days old).

Q0354 Ahmed,A., Singh,J., Khan,Y., Seshan,S.V., Girardi,G. A New Mouse Model to Explore Therapies for Preeclampsia. PLoS One 2010; 5(-10-):U325-U333. >>> Vascular endothelial growth factor (121); PBS, sterile; SC; Mice; 7 days; Animal info (CBA/J x DBA/2 and CBA/J x BALB/c).

Q0282 Schmidt,C., Bezuidenhout,D., Beck,M., Van der Merwe,E., Zilla,P., Davies,N. Rapid three-dimensional quantification of VEGF-induced scaffold neovascularisation by microcomputed tomography. Biomaterials 2009; 30(-30-):5959-5968. >>> Vascular endothelial growth factor (165); SC; Rat; 1002; 10 days; Controls received mp w/ PBS; animal info (male, Wistar, 234-254 g); functionality of mp verified by residual volume; post op. care (buprenorphine); pump connected to a porous polyurethane construct, schematic on Figure 1A;.

P9814 Santulli,G., Ciccarelli,M., Palumbo,G., Campanile,A., Galasso,G., Ziaco,B., Altobelli,G.G., Cimini,V., Piscione,F., D'Andrea,L.D., Pedone,C., Trimarco,B., Iaccarino,G. In vivo properties of the proangiogenic peptide QK. Journal of Translational Medicine 2009; 7(-;-):U1-U10. >>> Vascular endothelial growth factor-15; vascular endothelial growth factor-165; QK; IA (femoral); Rat; 2002; 14 days; Peptides; animal info (12 wks old, WKY, normosensitive); QK is a de novo engineered VEGF mimicking peptide.

P9708 Schmidt,N.O., Koeder,D., Messing,M., Mueller,F.J., Aboody,K.S., Kim,S.U., Black,P.M., Carroll,R.S., Westphal,M., Lamszus,K. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Research 2009; 1268(-;-):24-37. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS (parenchyma); Mice (nude); 2004; ; Controls received mp w/PBS; animal info (6 wks old).

P9443 Segi-Nishida,E., Warner-Schmidt,J.L., Duman,R.S. Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-32-):11352-11357. >>> Vascular endothelial growth factor 164, recomb. rat; PBS; CSF/CNS; Rat; 1003D; 3 days; 24 hours; Controls received mp w/ vehicle; brain tissue distribution; peptides; animal info (male, Sprague Dawley, 175-200 g.); delayed delivery (in the 48 hour infusion, PBS infused for 24 hours to "avoid the influence of cannulation and anesthesia." (p. 11354) then VEGF infused for 24 hours).

P9248 Poesen,K., Lambrechts,D., Van Damme,P., Dhondt,J., Bender,F., Frank,N., Bogaert,E., Claes,B., Heylen,L., Verheyen,A., Raes,K., Tjwa,M., Eriksson,U., Shibuya,M., Nuydens,R., Van den Bosch,L., Meert,T., D'Hooge,R., Sendtner,M., Robberecht,W., Carmeliet,P. Novel Role for Vascular Endothelial Growth Factor (VEGF) Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration. Journal of Neuroscience 2008; 28(-42-):10451-10459. >>> Vascular endothelial growth factor-B186, recomb. mouse; CSF, artificial; CSF/CNS; Rat; 2004; 100 days; Controls received mp w/ vehicle; long-term study; pumps replaced every 25 days; no stress (see pg. 10456); stability verified by 4 weeks in mp at 37 degrees Celsius; animal info (HAN-Wistar x Sprague Dawley-hSOD1G93A, 60 days old); behavioral testing (Rotarod test); "this delivery route was chosen because previous studies demonstrated that intracerebroventricularly delivered VEGF diffuses from the CSF into the neural parenchyma, where it reaches it's target motor neurons." (p. 10456).

P9198 Rennel,E.S., Hamdollah-Zadeh,M.A., Wheatley,E.R., Magnussen,A., Schueler,Y., Kelly,S.P., Finucane,C., Ellison,D., Cebe-Suarez,S., Ballmer-Hofer,K., Mather,S., Stewart,L., Bates,D.O., Harper,S.J. Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. European Journal of Cancer 2008; 44(-13-):1883-1894. >>> Vascular endothelial growth factor-165-b, recomb.; NaCl, sterile; SC; Mice; 28 days; No stress (see pg. 1888); half-life (p. 1893) 25 min in mice, 13.8-72 min in rats; cancer (colon); post op. care (Temgesic); animal info (C57/Bl6, 720 g.); silk sutures used; "no adverse effects were observed with this infusion of VEGF165b" pg. 1888; compound is an anti angiogenic isoform of VEGF.

P9139 Nicoletti,J.N., Shah,S.K., McCloskey,D.P., Goodman,J.H., Elkady,A., Atassi,H., Hylton,D., Rudge,J.S., Scharfman,H.E., Croll,S.D. Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience 2008; 151(-1-):232-241. >>> Vascular endothelial growth factor, recomb. human; BowAng1; Flt-Fc; CSF/CNS (dorsal hippocampus); Rat; 5 days; Controls received mp w/ PBS; animal info (male, Sprague Dawley, adult, 250-350 g.); cannula, polyvinyl catheter from Plastics One used; BowAng1 is a fusion of four molecules of angiopoietin-1 with two molecules of hFC; Flt-Fc is an immunoadhesin.

P9097 Ohm,J.E., Gabrilovich,D.I., Sempowski,G.D., Kisseleva,E., Parman,K.S., Nadaf,S., Carbone,D.P. VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression. Blood 2003/6/15; 101(-12-):4878-4886. >>> Vascular endothelial growth factor; SC; Mice (transgenic); 7-28 days; Controls received mp w/ PBS; no stress (see pg. 4880); animal info (female, 6-8 wks old, DO11.10); immunology.

P8833 Boodhwani,M., Voisine,P., Rue,M., Sodha,N.R., Feng,J., Xu,S.H., Bianchi,C., Settke,F.W. Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction. European Journal of Cardio-thoracic Surgery 2008; 33(-4-):645-650. >>> Vascular endothelial growth factor 165, recomb. human; Heparin; Intramyocardial; Pig (miniswine); 2ML4; 4 weeks; Tissue perfusion (myocardial); half-life (p. 649) "short"; cardiovascular; peptides; ischemia (cardiac); animal info (Yucatan mini-swine, 20-30 kg.).

P8799 Tsuchiya,A., Heike,T., Baba,S., Fujino,H., Umeda,K., Matsuda,Y., Nomoto,M., Ichida,T., Aoyagi,Y., Nakahata,T. Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease. Biochemical and Biophysical Research Communications 2008; 365(-3-):595-601. >>> Vascular endothelial growth factor-inhibitor; DMSO; IP; Mice; 9, 11 days; Controls received mp w/ vehicle; animal info (C57BL/6; 4, 8, 12 wks old; anti-Fas Ab-induced liver damage); agent also known as CBO-P11.

P8512 Huang,Y., Chen,X., Dikov,M.M., Novitskiy,S.V., Mosse,C.A., Yang,L., Carbone,D.P. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 2007; 110(-2-):624-. >>> Vascular endothelial growth factor 165, recomb. human; vascular endothelial growth factor, receptor-2 selective; vascular endothelial growth factor, receptor-1 selective; Mice; 2004; 28 days; Controls received mp w/ PBS; cancer; peptides; animal info (female, Balb/c, 6-8 weeks old); angiogenesis; hematology.

P8366 Dorrell,M.I., Aguilar,E., Scheppke,L., Barnett,F.H., Friedlander,M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-3-):967-972. >>> Vascular endothelial growth factor, aptamer; EMD472523; T2-TrpRS; PBS; CSF/CNS (intratumoral); Rat; 2001D; 2ML2; 2ML4; 3,6 days; 24 hours; Controls received mp w/ vehicle; cancer (gliosarcoma); animal info (male, Fischer, 344); EMD472523 is an integrin antagonist, VEGF aptamer is chemically identical to Macugen; T2 is a proteolytic fragment of tryptophan tRNA synthetase; all agents have angiostatic activity; tissue perfusion (tumor).

P8306 Tiranathanagul,K., Dhawan,V., Lytle,I.F., Zhang,W., Borschel,G.H., Buffington,D.A., Tziampazis,E., Brown,D.L., Humes,H.D. Tissue engineering of an implantable bioartificial hemofilter. ASAIO Journal 2007; 53(-2-):176-186. >>> Platelet-derived growth factor-BB; vascular endothelial growth factor 164; Saline, normal; albumin, rat serum; acetic acid; IA (femoral); IV (femoral); Rat; 2004; 28 days; Artificial kidney; controls received mp w/ vehicle; peptides; animal info (male, Fisher 344); mp attached by cannula to bioartificial hemofilter device, which surrounded and delivered agent to the femoral vessels; nephrology.

P8299 Cruze,C.A., Su,F., Limberg,B.J., Deutsch,A.J., Stoffolano,P.J., Dai,H.J., Buchanan,D.D., Yang,H.T., Terjung,R.L., Spruell,R.D., Mittelstadt,S.W., Rosenbaum,J.S. The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency. Peptides 2007; 28(-2-):269-280. >>> Peptide YY, recomb. human; peptide YY (3-36), recomb. human; vascular endothelial growth factor 165; PBS; glycerol; sodium citrate; Tween 20; IA (iliac); Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (femoral artery occlusion); dose-response (fig. 4); half-lfie (p. 276)<30 minutes; cardiovascular; peptides; ischemia (hindlimb); animal info (male, Sprague-Dawley, 325-350 grams).

P8267 Warner-Schmidt,J.L., Duman,R.S. VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-11-):4647-4652. >>> Vascular endothelial growth Factor 164, recomb. rat; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, 175-200g.).

P8196 Heymans,S., Luttun,A., Nuyens,D., Theilmeier,G., Creemers,E., Moons,L., Dyspersin,G.D., Cleutjens,J.P., Shipley,M., Angellilo,A., Levi,M., Nube,O., Baker,A., Keshet,E., Lupu,F., Herbert,J.M., Smits,J.F., Shapiro,S.D., Baes,M., Borgers,M., Collen,D., Daemen,M.J., Carmeliet,P. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat.Med. 1999/10; 5(-10-):1135-1142. >>> Vascular endothelial growth factor 165, recomb. human; SC; Mice; 2001; 7 days; Controls received no treatment; cardiovascular; peptides; ischemia (cardiac); animal info (8-12 weeks old); myocardial infarction by coronary artery ligation.

P8163 Boodhwani,M., Mieno,S., Voisine,P., Feng,J., Sodha,N., Li,J., Sellke,F.W. High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine. Journal of Thoracic and Cardiovascular Surgery 2006; 132(-6-):1299-1306. >>> Vascular endothelial growth factor 165, recomb. human; Heparin; Perivascular (circumflex coronary artery); Mini-pig; 2ML4; 4 weeks; Cardiovascular; peptides; ischemia (cardiac); animal info (male, female, yucatan, 20-30 kg, 23 weeks old).

P8096 Gosain,A., Matthies,A.M., Dovi,J.V., Barbul,A., Gamelli,R.L., DiPietro,L.A. Exogenous pro-angiogenic stimuli cannot prevent physiologic vessel regression. Journal of Surgical Research 2006; 135(-2-):218-225. >>> Vascular endothelial growth factor 164, recomb.; platelet-dreived growth factor; fibroblast growth factor-2; Wound site; Mice; 2002; 11 days; Controls received mp w/ PBS; functionality of mp verified by VEGF levels in wound sponges, residual volume; stability verified by activity of residual VEGF in endothelial cell cord formation assay (fig.4); cardiovascular; peptides; animal info (female, BALB/c, 8-9 wks old, implanted sponge wounds); "The activity of VEGF isolated from the pump was comparable to fresh recombinant VEGF 164, confriming that the recombinant growth factors present in the mini-osmotic pump retain robust biological activity." (p.221).

P8017 Kawai,T., Takagi,N., Mochizuki,N., Besshoh,S., Sakanishi,K., Nakahara,M., Takeo,S. Inhibitor of vascular endothelial growth factor receptor tyrosine kinase attenuates cellular proliferation and differentiation to mature neurons in the hippocampal dentate gyrus after transient forebrain ischemia in the adult rat. Neuroscience 2006; 141(-3-):1209-1216. >>> Vascular endothelial growth factor receptor tyrosine kinase inhibitor; DMSO; CSF/CNS (dentate gyrus); Rat; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig. 4); enzyme inhibitor (VEGF receptor tyrosine kinase); ischemia (transient forebrain); animal info (male, Wistar, 8 weeks old, carotid artery occlusion); 0.5% DMSO; agent also known as 4-[(4'-chloro-2'-fluoro) phenylamino]-6,7-dimethoxyquinazoline; tissue perfusion (dentate gyrus).

P7987 Wang,Y.M., Galvan,V., Gorostiza,O., Ataie,M., Jin,K.L., Greenberg,D.A. Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. Brain Research 2006; 1115(--):186-193. >>> Vascular endothelial growth factor; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral); behavioral study.

P7784 Gaudio,E., Barbaro,B., Alvaro,D., Glaser,S., Francis,H., Ueno,Y., Meininger,C.J., Franchitto,A., Onori,P., Marzioni,M., Taffetani,S., Fava,G., Stoica,G., Venter,J., Reichenbach,R., De Morrow,S., Summers,R., Alpini,G. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 2006; 130(-4-):1270-1282. >>> Vascular endothelial growth factor-A, recomb. mouse; vascular endothelial growth factor-C, recomb. mouse; Saline; BSA; IP; Rat; 1 week; Controls received mp w/ vehicle; peptides; animal info (male, Fischer 344, 150-175g.).

P7731 Carr,A.N., Howard,B.W., Yang,H.T., Eby-Wilkens,E., Loos,P., Varbanov,A., Qu,A., DeMuth,J.P., Davis,M.G., Proia,A., Terjung,R.L., Peters,K.G. Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: Support for an endothelium-dependent mechanism. Cardiovascular Research 2006; 69(-4-):925-935. >>> Vascular endothelial growth factor; stromal cell-derived factor-1a; PBS; glycerol; sodium acetate; sodium azide; IA (iliac); Rat; 2 weeks; Controls received mp w/ vehicle; dose-response (table 1); cardiovascular; peptides; animal info (adult); bilateral femoral artery ligation; occlusive cardiovascular disease.

P7561 Sun,Y.J., Jin,K.L., Childs,J.T., Xie,L., Mao,X.O., Greenberg,D.A. Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration. Developmental Biology 2006; 289(-2-):329-335. >>> Vascular endothelial growth factor-B; CSF, artificial; CSF/CNS; Rat; mice; 1003D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral); animal info (mice, 10-12 wk old; male, Sprague-Dawley).

P7495 Burchardt,M., Burchardt,T., Anastasiadis,A.G., Buttyan,R., de la Taille,A., Shabsigh,A., Frank,J., Shabsigh,R. Application of angiogenic factors for therapy of erectile dysfunction: protein and DNA transfer of VEGF 165 into the rat penis. UROLOGY 2005; 66(-3-):665-670. >>> Vascular endothelial growth factor, human 165; Saline, sterile; heparin; IA (renal); Rat; 2004; 28 days; Controls received mp w/ vehicle; functionality of mp verified by VEGF serum immunoassay; comparison of CDNA plasmid micro-injections vs. mp; gene therapy; peptides; animal info (male, Sprague-Dawley); urology; 2000 Units of heparin used.

P7417 Schmidt,N.O., Przylecki,W., Yang,W., Ziu,M., Teng,Y., Kim,S.U., Black,P.M., Aboody,K.S., Carroll,R.S. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. NEOPLASIA 2005; 7(-6-):623-629. >>> Vascular endothelial growth factor, recomb. human; CSF/CNS (parenchyma); Mice; 2004; ; Controls received mp w/ PBS; functionality of mp verified by residual volume; cancer.

P6908 Alonso,G., Galibert,E., Duvoid-Guillou,A., Vincent,A. Hyperosmotic stimulus induces reversible angiogenesis within the hypothalamic magnocellular nuclei of the adult rat: a potential role for neuronal vascular endothelial growth factor. BMC NEUROSCIENCE 2005; 6(--):U1-U19. >>> Antibody, anti-vascular endothelial growth factor; PBS; CSF/CNS (supraoptic nucleus); Rat; 1007D; 6 days; Schematic fig 9; 10 mm, 26 gauge cannula used.

P6834 Hashiya,N., Jo,N., Aoki,M., Matsumoto,K., Nakamura,T., Sato,Y., Ogata,N., Ogihara,T., Kaneda,Y., Morishita,R. In vivo evidence of angiogenesis induced by transcription factor ets-1 - Ets-1 is located upstream of angiogenesis cascade. Circulation 2004; 109(-24-):3035-3041. >>> Antibody, anti-vascular endothelical growth factor; antibody, immunoglobulin G, rabbit; IP; Mice; ; Cardiovascular; ischemia.

P6774 Bello,L., Lucini,V., Costa,F., Pluderi,M., Giussani,C., Acerbi,F., Carrabba,G., Pannacci,M., Caronzolo,D., Grosso,S., Shinkaruk,S., Colleoni,F., Canron,X., Tomei,G., Deleris,G., Bikfalvi,A. Combinatorial administration of molecules that simultaneously inhibit angiogenesis and invasion leads to increased therapeutic efficacy in mouse models of malignant glioma. Clinical Cancer Research 2004; 10(-13-):4527-4537. >>> PEX, recomb. human; PF-4/CTF; P4-4/DLR; vascular endothelial growth inhibitor, cyclo-; Water, sterile; SC; Mice; mice (nude); 2004; 28, 112, 140 days; Dose-response; long-term study; pumps replaced every 28 days; no stress (see pg. 4532); cancer (glioma); peptides; "The treatment was always very well tolerated without the occurrence of any side effects." (p. 4532); angiogenesis inhibitor.

P6730 Storkebaum,E., Lambrechts,D., Dewerchin,M., Moreno-Murciano,M.P., Appelmans,S., Oh,H., Van Damme,P., Rutten,B., Man,W.Y., De Mol,M., Wyns,S., Manka,D., Vermeulen,K., Van den Bosch,L., Mertens,N., Schmitz,C., Robberecht,W., Conway,E.M., Collen,D., Moons,L., Carmeliet,P., Carmeliet,P. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nature Neuroscience 2005; 8(-1-):85-92. >>> Vascular endothelial growth factor, recomb. rat; CSF/CNS; Rat; 2004; 100 days; Long-term study; pumps replaced every 28 days; ALZET brain infusion kit used; VEGF was cleared from CSF within 3h; "70-80% of VEGF in pumps remained active after 4 weeks."; neurodegenerative (Amyotrophic Lateral Sclerosis).

P6715 Ohm,J.E., Shurin,M.R, Esche,C., Lotze,M.T., Carbone,D.P, Gabrilovich,D. Effect of vascular Endothelial Growth Factor and FLT3 Ligand on Dendritic Cell Generation in Vivo. The Journal of Immunology 1999; 163(--):3260-3268. >>> Vascular endothelial growth factor; PBS; SC; Mice; 14 days; Controls received mp w/ vehicle; cancer; immunology.

P6634 Croll,S.D., Ransohoff,R.M., Cai,N., Zhang,Q., Martin,F.J., Wei,T., Kasselman,L.J., Kintner,J., Murphy,A.J., Yancopoulos,G.D., Wiegand,S.J. VEGF-mediated inflammation precedes angiogenesis in adult brain. Experimental Neurology 2004; 187(-2-):388-402. >>> Vascular endothelial growth factor 164, mouse; Flt-Fc; angiopoietin I, human; angiopoietin II, human; PBS; CSF/CNS (frontoparietal cortex); Rat; 2002; 1,2,3,4,5,7 days; Controls received mp w/ vehicle or hFc; dose-response (fig. 1); brain tissue distribution; peptides; cyanoacrylate adhesive (Loctite 495).

P6614 Kodama,I., Niida,S., Sanada,M., Yoshiko,Y., Tsuda,M., Maeda,N., Ohama,K. Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. Journal of Bone and Mineral Research 2004; 19(-2-):200-206. >>> Antibody, anti-vascular endothelial growth factor; vascular endothelial growth factor; Flt-1/Fe chimera; SC; Mice; 1002; 2 weeks; Plasma levels taken.

P6564 Suzuki,O., Bishop,A.T., Sunagawa,T., Katsube,K., Friedrich,P.F. VEGF-promoted surgical angiogenesis in necrotic bone. MICROSURGERY 2004; 24(-1-):85-91. >>> Vascular endothelial growth factor 165; Phosphate buffer; albumin rabbit serum; Bone; Rabbit; 1003D; 3 days.

P6459 Ward,W.K., Quinn,M.J., Wood,M.D., Tiekotter,K.L., Pidikiti,S., Gallagher,J.A. Vascularizing the tissue surrounding a model biosensor: how localized is the effect of a subcutaneous infusion of vascular endothelial growth factor (VEGF). BIOSENSORS&BIOELECTRONICS 2003; 19(-3-):155-163. >>> Vascular endothelial growth factor 165; PBS; BSA; SC; Rat; 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 157); mp primed 40 hours at 38 degrees Celsius; "the rats tolerated the implants well without distress." (P.157); mp explanted at day 40.

P6370 Manoonkitiwongsa,P.S., Schultz,R.L., McCreery,D.B., Whitter,E.F., Lyden,P.D. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis. Journal of Cerebral Blood Flow and Metabolism 2004; 24(-6-):693-702. >>> Vascular endothelial growth factor; Saline; IA (carotid); Rat; 2001; 7 days; Controls received mp w/ vehicle; dose response (p. 697); stroke; ischemia (cerebral); biocompatible glue was used to secure catheter in artery.

P5978 Luttun,A., Tjwa,M., Moons,L., Wu,Y., Angelillo-Scherrer,A., Liao,F., Nagy,J.A., Hooper,A., Priller,J., De Klerck,B., Compernolle,V., Daci,E., Bohlen,P., Dewerchin,M., Herbert,J.M., Fava,R., Matthys,P., Carmeliet,G., Collen,D., Dvorak,H.F., Hicklin,D.J., Carmeliet,P. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nature Medicine 2002; 8(-8-):831-840. >>> Placental growth factor; vascular endothelial growth factor; SC; Mice; 2001; 7 days; Angiogenesis.

P5966 Roguin,A., Avivi,A., Nitecki,S., Rubinstein,I., Levy,N.S., Abassi,Z.A., Resnick,M.B., Lache,O., Melamed-Frank,M., Joel,A., Hoffman,A., Nevo,E., Levy,A.P. Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES O F AMERICA 2003; 100(-8-):4644-4648. >>> DNA, naked; vascular endothelial growth factor, DNA; Water; IM; Mice; 2001; 7 days; Controls received mp w/ saline; tissue perfusion (quadriceps muscle); gene therapy; fenestrated catheter; pump implanted IP; "we have shown that when using plamid DNA, continuous administration is superior to multiple simultaneous IM injections." (p. 4647).

P5929 Namba,T., Koike,H., Murakami,K., Aoki,M., Makino,H., Hashiya,N., Ogihara,T., Kaneda,Y., Kohno,M., Morishita,R. Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model. Circulation 2003; 108(-18-):2250-2257. >>> Immunoglobulin G; antibody, anti-vascular endothelial growth factor; IP; Rat; 28 days; Cardiovascular; peptides; pump model not stated; ischemia (hind-limb).

P5731 Sun,Y.J., Jin,K.L., Xie,L., Childs,J., Mao,X.O., Logvinova,A., Greenberg,D.A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. Journal of Clinical Investigation 2003; 111(-12-):1843-1851. >>> Vascular endothelial growth factor; vascular endothelial growth factor R2/FC chimera; Phosphate buffer; BSA; Bone (tibia); Rabbit; 2ML2; 3 days; Controls received mp w/ vehicle; tissue perfusion (osteotomy site); replacement therapy (distraction osteogenesis); stability verified by in vitro assay for 2 weeks at 37 C. (p. 336);.

P5645 Pipp,F., Heil,M., Issbrucker,K., Ziegelhoeffer,T., Martin,S., van den Heuvel,J., Weich,H., Fernandez,B., Golomb,G., Carmeliet,P., Schaper,W., Clauss,M. VEGFR-1-selective VEGF homologue PlGF is arteriogenic - Evidence for a monocyte-mediated mechanism. Circulation Research 2003; 92(-4-):378-385. >>> Vascular endothelial growth factor; Vascular endothelial growth factor-E; Monocyte chemoattractant protein-1; Placental growth factor; Phosphate buffer; albumin; IA (femoral); Mice; rabbit; 1 week; Controls received mp w/ vehicle; dose-response (p.381); peptides; placenta growth factor (PlGF) is a VEGF homologue; VEGF-E is a chimera containing the heparin-binding domain of VEGF; MCP-1.

P5606 Harrigan,M.R., Ennis,S.R., Sullivan,S.E., Keep,R.F. Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume. Acta Neurochirurgica 2003; 145(-1-):49-53. >>> Vascular endothelial growth factor 165; PBS; BSA; CSF/CNS; Rat; 2001; 7 days; Controls received mp/ w vehicle; cardiovascular; peptides; ALZET brain infusion kit used; VEGF was recomb. human; ischemia (cerebral); MCAO.

P5323 Proescholdt,M.A., Jacobson,S., Tresser,N., Oldfield,E.H., Merrill,M.J. Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats. Journal of Neuropathology and Experimental Neurology 2002; 61(-10-):914-925. >>> Vascular endothelial growth factor; PBS; Albumin, rabbit serum; CSF/CNS (sciatic nerve); Rabbit; 1003D; 12 days; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve graft); peptides; human recomb. VEGF used; transplantation;.

P5197 Masaki,I., Yonemitsu,Y., Yamashita,A., Sata,S., Tanii,M., Komori,K., Nakagawa,K., Hou,X., Nagai,Y., Hasegawa,M., Sugimachi,K., Sueishi,K. Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2. Circ.Res 2002/5/17; 90(-9-):966-973. >>> Antibody, anti-Vascular Endothelial Growth Factor; Immunoglobulin G; IP; Mice; 1007D; 7 days; Peptides; VEGF levels checked by ELISA; ischemia (limb).

P5132 Yang,R.H., Ogasawara,A.K., Zioncheck,T.F., Ren,Z., He,G.W., DeGuzman,G.G., Pelletier,N., Shen,B.Q., Bunting,S., Jin,H.K. Exaggerated hypotensive effect of vascular endothelial growth factor in spontaneously hypertensive rats. Hypertension 2002; 39(--):815-820. >>> Vascular Endothelial Growth Factor; Saline; IV (jugular); rat; 7 days; controls received mp w/ vehicle; cardiovascular; antihypertensive.

P5053 Harrigan,M.R., Ennis,S.R., Masada,T., Keep,R.F. Intraventricular infusion of vascular endothelial growth factor promotes cerebral angiogenesis with minimal brain edema. Neurosurgery 2002; 50(-3-):589-598. >>> Vascular Endothelial Growth Factor; PBS; Albumin, bovine serum; CSF/CNS; CSF/CNS (cortex); CSF/CNS (third ventricle); rat; 2001; 7 days; controls received mp w/ vehicle; dose response (p. 591); half-life = 6 min. (p. 594); peptides; brain tissue distribution; VEGF was human recombinant; benefits of continuous infusion p. 594.

P5032 Krum,J.M., Mani,N., Rosenstein,J.M. Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain. Neuroscience 2002; 110(-4-):589-604. >>> Vascular endothelial growth factor; PBS; CSF/CNS (striatum); rat; 2001; 1, 3 or 7 days; controls received mp w/ vehicle; comparison of gelfoam sponge administration vs. mp infusion; stress/adverse reaction (p. 592) necrotic tissue or cavity around cannula; peptides; brain tissue distribution, VEGF was recombinant human; some controls received cannulas with no pump attached.

P4874 Masuda,Y., Shimizu,A., Mori,T., Ishiwata,T., Kitamura,H., Ohashi,R., Ishizaki,M., Asano,G., Sugisaki,Y., Yamanaka,N. Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. American Journal of Pathology 2001; 159(--):599-608. >>> Vascular endothelial growth factor; Saline; IP; rat; 2ML1; 7 days; controls received mp w/ vehicle; immunology; peptides;.

P4782 Yang,H.T., Yan,Z., Abraham,J.A., Terjung,R.L. VEGF121- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production.. American Journal of Physiology-Heart and Circulatory Physiology 2001; 280(--):H1097-H1104. >>> Vascular endothelial growth factor 121; Fibroblast growth factor, basic;; PBS; Sodium citrate; Glycerol;; IA (femoral);; rat;; 2002;; 14 days;; Controls received mp w/ vehicle; cardiovascular; peptides; vehicle was PBS w/ 10% sodium citrate and 1.6% glycerol; sodium citrate used to prevent coagulation; glycerol used to enhance protein stability;.

P4582 Lindner,V, Reidy,M.A. Expression of VEGF receptors in arteries after endothelial injury and lack of increased endothelial regrowth in response to VEGF.. Arterioscler.Thromb.Vasc.Biol. 1996; 16(--):1399-1405. >>> Vascular endothelial growth factor;; Saline;; IV (jugular);; rat;; 2ML2;; 2 weeks;; controls received mp w/vehicle; comparison of bolus injections vs. mp; peptides; recomb. human VEGF used;.

P4465 Gabrilovich,D, Ishida,T, Oyama,T, Ran,S, Kravtsov,V, Nadaf,S, Carbone,D.P. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo.. Blood 1998/12/1; 92(-11-):4150-4166. >>> Vascular endothelial growth factor;; PBS;; SC;; mice;; 14, 28 days;; controls received mp w/vehicle; functionality of mp verified by plasma levels; dose-response (p. 4152); immunology; peptides; "Because VEGF has a short in vivo half-life ..., we used an in vivo model utilizing a continuous infusion of VEGF via an osmotic infusion pump" (p. 4159).

P4375 Rosenstein,J.M., Mani,N., Silverman,W.F., Krum,J.M. Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc.Natl.Acad.Sci.USA 1998/6; 95(--):7086-7091. >>> Vascular endothelial growth factor;; PBS;; CSF/CNS (cortex);; rat;; 2001;; 7 days;; controls received mp with vehicle; peptides;.

P4345 Proescholdt,M.A., Heiss,J.D., Walbridge,S., Muhlhauser,J., Capogrossi,M.C., Oldfield,E.H., Merrill,M.J. Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain. Journal of Neuropathology and Experimental Neurology 1999/6; 58(-6-):613-627. >>> Vascular endothelial growth factor; Vitronectin, rat; PBS; Albumin, rat serum; CSF/CNS; Rat; 2001; 6,12 days; Controls received mp with vehicle; immunology; peptides; brain tissue distribution assessed with anti-VEGF antibody immunostaining; recomb. human, carrier-free VEGF 165 used; VEGF infused alone or with rat vitronectin, which is an extracellular matrix protein;.

P4128 Hopkins,S.P., Bulgrin,J.P., Sims,R.L., Bowman,B., Donovan,D.L., Schmidt,S.P. Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia. J.Vasc.Surg. 1998; 27(-5-):886-895. >>> Vascular endothelial growth factor; Nitroglycerin; Saline; Heparin; IA (iliac); rabbit; 2ML4; 28 days; pump diagram (p. 888); 22 g intravenous catheter was inserted into tygon tubing; "implantable osmotic pumps offer an alternative simple delivery method, providing a constant release of soluble agents in a steady-state fashion." (p. 892); controls received mp w/vehicle; good methods (pp. 887-888); cardiovascular; peptides; ischemia.

P3458 Lopez,J.J., Simons,M. Local extravascular growth factor delivery in myocardial ischemia. Drug Delivery 1996; 3(--):143-147. >>> Vascular endothelial growth factor; Heparin; Saline, sterile;; perivascular (circumflex artery adventitia); pig; 2ML2; 4 weeks; tissue perfusion (adventitia); peptides; pumps placed inside chest wall; cardiovascular; ischemia (cardiac).

P3411 Harada,K., Friedman,M., Lopez,J.J., Wang,S.Y., Li,J., Prasad,P.V., Pearlman,J.D., Edelman,E.R., Sellke,F.W., Simons,M. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am.J.Physiol.(Heart Circ.Physiol.39) 1996; 270(--):H1791-H1802. >>> Vascular endothelial growth factor; Saline; Heparin; perivascular (circumflex coronary artery); pig; 2ML4; 4 weeks; controls received vehicle infusion; tissue perfusion (adventitia of coronary artery); peptides; ischemia (cardiac); 250 U/ml of heparin.

P3119 Sellke,F.W., Wang,S.Y., Friedman,M., Dai,H.B., Harada,K., Lopez,J.J., Simons,M. B-adrenergic modulation of the collateral-dependent coronary microcirculation. J.Surg.Res. 1995; 59(--):185-190. >>> Vascular endothelial growth factor; Saline; Heparin; perivascular (circumflex coronary artery); pig; 2ML4; no duration posted; controls received occluder&mp with vehicle; peptides; ameroid occluder placed around LCX coronary artery; pump catheter placed distal to this; pump sutured to chest wall; tissue perfusion (perivascular); 25 U/ml of heparin.

top of page

Looking for references? We can help!

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying ...

“Moreover, the replacement of pumps is a relatively simple surgical procedure (Prieskorn and Miller, 200). Allowing longer-term (> 1 month) experiments to be performed.” Shepherd et al., Hearing Research 2002;172:92-98.