References on the Administration of Growth Hormone and Somatomedin Using ALZET® Osmotic Pumps

1. Growth Hormone, Bovine

11655 Walser, M., Hansen, A., Svensson, P.A., Jernaas, M., Oscarsson, J., Isgaard, J., Aaberg, N.D. Peripheral administration of bovine GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats. GROWTH HORMONE&IGF RESEARCH 2011; 21(-1-):16-24. >>> Growth hormone, bovine recomb.; Phosphate buffer; glycerol; sodium azide; SC; Rat; 2004; Animal info (female, Sprague Dawley, hx, normal); replacement therapy (hypophysectomized).

8773 Gaelman, C., Matasconi, M., Persson, L., Parini, P., Angelin, B., Rudling, M. Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2007; 293(-3-):E737-E742. >>> Growth hormone, bovine; SC; Rat; 2ML1; Controls received no treatment; peptides; animal info (male, Wistar-Hannover, 6, 18 months old); endocrinology.

8650 Gardmo, C., Mode, A. In vivo transfection of rat liver discloses binding sites conveying GH-dependent and female-specific gene expression. Journal of Molecular Endocrinology 2006; 37(-3-):433-441. >>> Growth hormone, bovine; SC; Rat; 2001; Peptides; animal info (Sprague-Dawley, 7 wks old, male).

8327 Kleinberg, D.L., Ruan, W.F., Yee, D., Kovacs, K.T., Vidal, S. Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice. Endocrinology 2007; 148(-3-):1080-1088. >>> Insulin-like growth factor I; growth hormone, bovine; insulin-like growth factor-1, binding protein; SC; Mice; 1007D; Controls received mp w/ saline; peptides; animal info (ORX, 10 weeks old, male); drugs delivered alone or in combination.

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2. Growth Hormone, Chicken

4652 Scanes, C.G., Proudman, J.A, Radecki, S.V. Influence of continuous growth hormone or insulin-like growth factor I administration in adult female chickens.. General and Comparative Endocrinology 1999; 114(--):315-323. >>> Growth hormone, chicken; Insulin-like growth factor I;; Saline; Albumin, bovine serum;; SC;; bird (chicken);; 2ML2;; controls received mp w/vehicle; functionality of mp verified by plasma levels; peptides; recomb. chicken growth hormone used;.

1526 Scanes, C.G., Peterla, T.A., Kantor, S., Ricks, C.A. In vivo effects of biosynthetic chicken growth hormone in broiler-strain chickens. Growth Dev. Aging 1990; 54(--):95-101. >>> Growth hormone, chicken; Albumin, bovine serum; Saline; SC; bird (chicken); 2ML4; pumps were siliconized (probably using Prosil) to decrease protein binding in pumps.

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3. Growth Hormone, Human

Q2050 Nishizawa,H., Takahashi,M., Fukuoka,H., Iguchi,G., Kitazawa,R., Takahashi,Y. GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model. Biochemical and Biophysical Research Communications 2012; 423(-2-):295-300. >>> Growth hormone; insulin-like growth factor I, recomb. human; Saline; SC; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (SDR, GH-def, male, 16 wks old).

Q1174 Kleinberg,D.L., Ameri,P., Singh,B. Pasireotide, an IGF-I action inhibitor, prevents growth hormone and estradiol-induced mammary hyperplasia. Pituitary 2011; 14(-1-):44-52. >>> Growth hormone, human; SC; Rat; 1007D; ; Animal info (CD-1, 42 days old); replacement therapy (hypophysectomy and oophorectomy).

Q0858 Tateno,C., Kataoka,M., Utoh,R., Tachibana,A., Itamoto,T., Asahara,T., Miya,F., Tsunoda,T., Yoshizato,K. Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver. Endocrinology 2011; 152(-4-):1479-1491. >>> Growth hormone, human; SC; Mice (transgenic/SCID); 2 weeks; Animal info (uPA/SCID, 20-30 days old, chimeric).

Q0698 Meyer,R.D., Laz,E.V., Su,T., Waxman,D.J. Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5. MOLECULAR ENDOCRINOLOGY 2009; 23(-11-):1914-1926. >>> Growth hormone, recomb. rat, human; Rat; 7 days; Controls were untreated; animal info (male, Fischer 344, 9-13 wks old); replacement therapy (hypophysectomy).

P9566 Gevers,E.F., Hannah,M.J., Waters,M.J., Robinson,I.C.A.F. Regulation of Rapid Signal Transducer and Activator of Transcription-5 Phosphorylation in the Resting Cells of the Growth Plate and in the Liver by Growth Hormone and Feeding. Endocrinology 2009; 150(-8-):3627-3636. >>> Growth hormone, human; Saline; BSA; SC; Mice; 2001; 5 days; Controls received sham surgery; animal info (dw/dw, 4-5 wks old).

P8592 Scheiwiller,E., Guler,H.P., Merryweather,J., Scandella,C., Maerki,W., Zapf,J., Froesch,E.R. Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I. Nature 1986; 323(-6084-):169-171. >>> Insulin-like growth factor I, recomb. human; insulin; growth hormone, human; Saline; acetic acid; Rat; 2001; 6 days; Replacement therapy (STZ-induced diabetes); dose-response (fig. 1); peptides; animal info (male, Tif RAI, 120-130 grams); endocrinology.

P8550 Henriquez-Hernandez,L.A., Flores-Morales,A., Santana-Farre,R., Axelson,M., Nilsson,P., Norstedt,G., Fernandez-Perez,L. Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat. Journal of Pharmacology and Experimental Therapeutics 2007; 320(-2-):695-705. >>> Growth hormone, recomb. human; Saline, physiological; SC; Rat; 2004; 1 week; Controls received mp w/ vehicle; replacement therapy (hypophysectomy); comparison of SC injections vs. mp; peptides; animal info (male, Sprague-Dawley, 2-3 months old).

P8538 Jarukamjorn,K., Sakuma,T., Jaruchotikamol,A., Oguro,M., Nemoto,N. Regulation of mouse hepatic CYP2D9 mRNA expression by growth and adrenal hormones. Drug Metabolism and Pharmacokinetics 2006; 21(-1-):29-36. >>> Growth hormone, recomb. human; Saline; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; or no treatment; comparison of SC injections vs. mp; animal info (male, female, C57BL/6NCRJ, 7-8 weeks old).

P7932 Zeinoaldini,S., Swarts,H.J.M., Van de Heijning,B.J.M. Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat. REGULATORY PEPTIDES 2006; 134(-2-3-):158-163. >>> Growth hormone, recomb. human; immunoglobulin G, goat; growth hormone, anti-rat; Saline, sterile; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; post op. care (analgesia, ibuprofen); animal info (female, Wistar, 45 grams).

P7539 Jarukamjorn,K., Sakuma,T., Jaruchotikamol,A., Ishino,Y., Oguro,M., Nemoto,N. Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver. Toxicology 2006; 219(-1-3-):97-105. >>> Growth hormone, recomb. human; Saline, normal; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; peptides; animal info (C57BL/6, male and female, 8 wk old); "Continuous GH administration allowed the GH level to be maintained relatively stably in the circulation compared with pulsatile GH administration". (p. 104).

P7492 Matasconi,M., Panini,P., Angelin,B., Rudling,M. Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: Effects of hypophysectomy and growth hormone treatment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2005; 1736(-3-):221-227. >>> Growth hormone, human; SC; Mice; 2001; 7 days; Controls received sham operation; replacement therapy (hypophysectomy); peptides; animal info (C57B1/6J, LDL R knockout, male).

P7350 Slagter,B.J., Kittilson,J., Sheridan,M.A. Expression of somatostatin receptor mRNAs is regulated in vivo by growth hormone, insulin, and insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss). REGULATORY PEPTIDES 2005; 128(-1-):27-32. >>> Growth hormone, recomb. bovine; insulin, recomb. bovine; insulin-like growth factor. recomb. human; NaCl; IP; Fish (rainbow trout); 1007D; 21 days; Controls received mp w/ vehicle; peptides; post op. care (topical antibiotic ointment); at 14 degrees celsius, the 1007D infuses at 0.14 ul/hr for approximately 21 days.

P6848 Kamegai,J., Tamura,H., Shimizu,T., Ishii,S., Tatsuguchi,A., Sugihara,H., Oikawa,S., Kineman,R.D. The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology 2004; 145(-8-):3731-3738. >>> Growth hormone, rat; insulin-like growth factor-1, recomb. human; Saline; SC; Rat; 1003D; 72 hours; Controls received mp w/ vehicle; peptides.

P6684 Sakuma,T., Kitajima,K., Nishiyama,M., Endo,Y., Miyauchi,K., Jarukamjorn,K., Nemoto,N. Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones. Biochemical and Biophysical Research Communications 2004; 314(-2-):495-500. >>> Growth hormone, recomb. human; SC; Mice; 1007D; 7 days; Functionality of mp verified by weight gain; replacement therapy (adrenalectomy); peptides.

P6657 Gevers,E.F., Van Der Eerden,B.C.J., Karperien,M., Raap,A.K., Robinson,I.C.A.F., Wit,J.M. Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate. Journal of Bone and Mineral Research 2002; 17(-8-):1408-1419. >>> Growth hormone, recomb. human; thyroxine; triiodothyronine; SC; Rat; 2 weeks; Controls received teflon rods; replacement therapy (hypophysectomy).

P6639 Bains,R.K., Wells,S.E., Flavell,D.M., Fairhall,K.M., Strom,M., Le Tissier,P., Robinson,I.C.A.F. Visceral obesity without insulin resistance in late-onset obesity rats. Endocrinology 2004; 145(-6-):2666-2679. >>> Growth hormone, human; SC; Rat; 4 weeks; Controls received no treatment; replacement therapy (GH deficiency); pumps replaced on day 13; peptides.

P6406 Cunnningham,M.J., Krasnow,S.M., Gevers,E.F., Chen,P., Thompson,C.K., Robinson,I.C.A.F., Smith,M.S., Clifton,D.K., Steiner,R.A. Regulation of galanin-like peptide gene expression by pituitary hormones and their downstream targets. Journal of Neuroendocrinology 2004; 16(-1-):10-18. >>> Growth hormone, recomb. human; SC; Rat; 2002; 2 weeks.

P6387 Matasconi,M., Angelin,B., Rudling,M. Pituitary control of lipoprotein and bile acid metabolism in male rats: growth hormone effects are not mediated by prolactin. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004; 287(-1-):E114-E119. >>> Growth hormone, human; growth hormone, bovine; SC; Rat; 2001; 7 days; Replacement therapy (hyphophysectomy); dose-response (p. E115).

P6263 Dhir,R.N., Shapiro,B.H. Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003; 100(-25-):15224-15228. >>> Growth hormone, human; IP; Rat; 1007D; 7 days; Peptides.

P5810 Hedlund,G.P., Carlsson,H.E., Shieck,E., Nilsson,I., Lundblad,C., Arons,S., Iversen,A.K., Looman,C., Jensen,H.E., Hau,J. Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland. In Vivo 2003; 17(-1-):1-4. >>> Insulin-like growth factor I; growth hormone, human; octreotide; Sodium acetate; benzylalcohol; water; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by IGF-I plasma levels; peptides; recomb. human IGF-I and recomb. human GF used; some animals received 2 pumps: one with octreotide and one with GH.

P5378 Sakuma,T., Endo,Y., Mashino,M., Kuroiwa,M., Ohara,A., Jarukamjorn,K., Nemoto,N. Regulation of the expression of two female-predominant CYP3A mRNAs (CY P3A41 and CYP3A44) in mouse liver by sex and growth hormones. Archives of Biochemistry and Biophysics 2002; 404(-2-):234-242. >>> Growth hormone, recomb. human; SC; Mice; 1007D; 7 days; Replacement therapy (orchidectomy or hypophysectomy); comparison of twice-daily SC injections vs mp; peptides.

P5120 Sahlin,L., Elger,W., Hedden,A., Lindberg,M., Reddersen,G., Schneider,B., Schwarz,S., Freyschuss,B., Eriksson,H. Effects of estradiol and estradiol sulfamate on the liver of ovariectomized or ovariectomized and hypophysectomized rats. Journal of Steroid Biochemistry and Molecular Biology 2002; 80(--):457-467. >>> Estradiol, 17B-; Estradiol sulfamate; Dexamethasone; Growth hormone, human; Propylene glycol; SC; rat; 2001; 7 days; controls received mp w/ vehicle; replacement therapy (ovariectomy, hypophysectomy, p. 458); comparison of oral administration vs. mp; steroid administered in PG, human GH pre-formulated.

P5083 Delhanty,P.J.D., Mesotten,D., McDougall,F., Baxter,R.C. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology 2002; 143(-6-):2445-2448. >>> Growth hormone, human; Growth hormone, porcine;; SC; rat; 24-48 hours; comparison of IP injections vs. mp; peptides; porcine or recomb. human GH used.

P4967 Tollet-Egnell,P., Flores-Morales,A., Odeberg,J., Lundeberg,J., Norstedt,G. Differential cloning of growth hormone-regulated hepatic transcripts in the aged rat. Endocrinology 2000; 141(--):910-921. >>> Growth hormone, human; rat; 2004; 3 weeks; controls received mp w/ vehicle; replacement therapy (hypophysectomy p. 911); peptides; recomb. human GH used;.

P4778 Pampori,N.A., Agrawal,A.K., Shapiro,B.H. Infusion of gender-dependent plasma growth hormone profiles into intact rats: Effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic CYP isoforms.. Drug Metabolism and Disposition 2001; 29(-1-):8-16. >>> Growth hormone, recomb.; Growth hormone, human;; SC; IP;; rat;; 7 days;; Controls received mp w/ vehicle; dose-response (p. 13 graphs); peptides; plasma GH differences by gender; both SC and IP routes used;.

P4663 Reinecke,M, Schmid,A.C, Heyberger-Meyer,B, Hunziker,E.B., Zapf,J. Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo.. Endocrinology 2000; 141(-8-):2847-2853. >>> Insulin-like growth factor I, recomb. human-; Growth hormone, recomb. human-;; Acetic acid;; SC;; rat;; 2002;; 24 hours;; functionality of mp verified by IGF-I serum levels; peptides..

P4578 Sun,Y-N, Lee,H.J, Almon,R.R, Jusko,W.J. A pharmacokinetic/pharmacodynamic model for recombinant human growth hormone effects on induction of insulin-like growth factor I in monkeys.. The Journal of Pharmacology and Experimental Therapeutics. 1999; 289(-3-):1523-1532. >>> Growth hormone, recomb. human; SC;; monkey;; 30 days;; comparison of SC injections vs. mp vs. microspheres; peptides; "Continuous rhGH input delivered by ProLease and osmotic pump is more effective than pulsatile injections in induction of IGF-I, especially when the delivery systems can maintain growth hormone concentration above the SC50" (p. 1531)..

P4487 Fhölenhag,K, Malmöf,K, Skottner,A, Nyberg,F. Effects of human growth hormone on the porto-arterial concentration differences of glucose and amino acids in the newborn piglet.. Horm.Metab.Res. 1999; 31(--):22-26. >>> Growth hormone, recomb. human;; PBS;; IP;; pig (neonate);; 2ML1;; 7 days;; controls received mp w/vehicle; peptides;.

P4433 Adams,G.R, McCue,S.A. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats.. J.Appl.Physiol. 1998; 4(-5-):1716-1722. >>> Insulin-like growth factor I; Growth hormone, recomb. human; Fibroblast growth factor, basic;; Saline;; IM;; rat;; 2004; 2002;; 2, 3 weeks;; controls received mp w/saline; tissue perfusion (tibialis anterior muscle); functionality of mp verified by residual volume and plasma levels; good methods (p. 1717); peptides; fenestrated catheter used; recomb. human IGF-I used; tygon tubing was fenestrated using microtipped soldering iron and bonded to c-flex tubing;.

P4159 Liao,W., Rudling,M., Angelin,B. Contrasting effects of growth hormone and insulin-like growth factor I on the biological activities of endotoxin in the rat. Endocrinology 1997; 138(-1-):289-295. >>> Growth hormone, recomb. human; Insulin-like growth factor I; SC; rat; 2001; 2ML1; 4 days; functionality of mp verified by IGF-1 plasma levels; peptides.

P4138 Turner,R.T. Effects of short-term spaceflight and recombinant human growth hormone (rhGH) on bone growth in young rats. Aviation Space Environ Med 1995; 66(--):763-769. >>> Growth hormone, recomb. human; Phosphate; F68 detergent; SC; rat; 5 days; controls received mp w/vehicle; peptides; spaceflight.

P4123 Adams,G.R., McCue,S.A. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J.Appl.Physiol. 1998; 84(-5-):1716-1722. >>> Insulin-like growth factor I; Growth hormone, recomb. human; Fibroblast growth factor 2; Saline; IM (tibialis anterior); rat; 2002; 2004; 2, 3 weeks; tissue perfusion (tibialis anterior muscle); functionality of mp verified by residual volume; good methods (p. 1717); peptides; fenestrated catheter tubing used; catheters consisted of C-flex implantable tubing bonded to fenestrated Tygon tubing.

P3975 Cha,M.C., Rojhani,A. Zinc deficiency inhibits the direct growth effect of growth hormone on the tibia of hypophysectomized rats. Biol.Trace.Elem.Res. 1997; 59(--):99-111. >>> Growth hormone, recomb. human; IA (femoral); rat; 2002; 13 days; controls received mp w/vehicle; replacement therapy (hypophysectomy); no stress (see pg. 103); stress/adverse reaction (p. 103); PE10, PE50 and PE60 tubing used; PE10 tubing was stretched to fit into the vessel; peptides;.

P3881 Haraldseth,O., Jones,R.A., Skottner,A. A quantitative in-vivo MR imaging study of brain dehydration in diabetic rats and rats treated with peptide hormones. Magnetic Resonance Imaging 1997; 15(-2-):203-210. >>> Insulin; Insulin-like growth factor I; Growth hormone, human; SC; rat;; 13-14 days; recomb. human IGF-1 and GH used; peptides.

P3807 Hedner,E., Linde,A., Nilsson,A. Systemically and locally administered growth hormone stimulates bone healing in combination with osteopromotive membranes: an experimental study in rats. J.Bone and Min.Res. 1996; 11(-12-):1952-1960. >>> Growth hormone, bovine; Growth hormone, human; Prolactin, ovine; SC; bone (mandible); rat; 2, 3, 4 weeks; controls received mp w/saline; pumps replaced after 2 weeks; recomb. human and bovine GH used.

P3689 Rudling,M., Olivecrona,H., Eggertsen,G., Angelin,B. Regulation of rat hepatic low density lipoprotein receptors. J.Clin.Invest. 1996; 97(-2-):292-299. >>> Growth hormone, recomb. human; Insulin-like growth factor I; Dexamethasone; Thyroxine, L-; rat; 2001; 2ML2; 6 days; controls received sham operation; replacement therapy (hypophysectomy); agent infusion rates given in ug/h; recomb. human IGF-I used.

P3564 LeRoith,D., Yanowski,J., Kaldjian,E.P., Jaffe,E.S., LeRoith,T., Purdue,K., Cooper,B.D., Pyle,R., Adler,W. The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. Endocrinology 1996; 137(-3-):1071-1079. >>> Insulin-like growth factor I; Growth hormone, human; Saline; Sodium acetate buffer; Benzyl alcohol; Tween 20; Sodium citrate; Phenol; SC; monkey; 2ML4; 7 weeks; controls received mp w/ vehicle; functionality of mp verified by serum levels; pumps replaced after 28 days; immunology; peptides; recomb. human IGF-1 and GH used; agents given singly and concomitantly.

P3534 Sass,D.A., Jerome,C.P., Bowman,A.R., Bennett-Cain,A., Ginn,T.A., LeRoith,D., Epstein,S. Short-term effects of growth hormone and insulin-like growth factor I on cancellous bone in rhesus macaque monkeys. J.Clin.Endocrinol.Metab. 1997; 82(-4-):1202-1209. >>> Insulin-like growth factor I; Growth hormone, recomb. human; Saline; Buffer, sodium acetate; Benzyl alcohol; Tween 20; Sodium citrate; Phenol; SC; monkey; 7 weeks; controls received mp w/ vehicle; pumps replaced after 4 weeks; peptides; recomb. human IGF-1 used; IGF-1 and growth hormone given singly and together; animals received 1-3 pumps.

P3527 Clark,R.G., Mortensen,D.L., Carlsson,L.M.S., Carlsson,B., Carmignac,D., Robinson,I.C.A. The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I. Endocrinology 1996; 137(-5-):1904-1912. >>> Growth hormone, recomb. human; Insulin-like growth factor I; SC; rat; 14 days; controls received vehicle infusion; comparison of daily injections vs. mp; peptides; recomb. human IGF-I used.

P3289 Jiang,B., Roy,R.R., Navarro,C., Edgerton,V.R. Absence of a growth hormone effect on rat soleus atrophy during a 4-day spaceflight. Am.Physiol.Soc. 1993; 74(-2-):527-531. >>> Growth hormone, recomb. human; Phosphate; F-68; SC; rat; 4 days; controls received mp w/ vehicle; functionality of mp verified by immunoassay; stability verified by HPLC; musculoskeletal; spaceflight.

P3226 Low,S.C., Chapman,K.E., Edwards,C.R.W., Wells,T., Robinson,I.C.A.F., Seckl,J.R. Sexual dimorphism of hepatic 11B-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns. J.Endocrinol. 1994; 143(--):541-548. >>> Growth hormone, human; SC; no duration posted; replacement therapy (GH-deficient dwarf rats used + hypophysectomized normal rats); comparison of pulsed iv injections vs. mp; peptides.

P3218 Jellinck,P.H., Makin,H.L.J., Sepkovic,D.W., Bradlow,H.L. Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes. J.Steroid Biochem.Molec.Biol. 1993; 46(-6-):791-798. >>> Growth hormone, human; rat; 4 days; cancer; peptides.

P3184 Gosteli-Peter,M.A., Winterhalter,K.H., Schmid,C., Froesch,E.R., Zapf,J. Expression and regulation of insulin-like growth factor-I (IGF-1) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology 1994; 135(--):2558-2567. >>> Insulin-like growth factor I; Growth hormone, recomb. human; Saline; Water; IP; rat; 2001; 6 days; controls received no treatment or mp with vehicle; replacement therapy (hypophysectomy); peptides; recomb. human IGF-1 used.

P3181 Bennett,P.A., Levy,A., Sophokleous,S., Robinson,I.C.A.F., Lightman,S.L. Hypothalamic GH receptor gene expression in the rat: effects of altered GH status. J.Endocrinol. 1995; 147(--):225-234. >>> Growth hormone, recomb. human; SC; CSF/CNS; rat; 6 days; controls received teflon rods; replacement therapy (dwarf rats used); peptides.

P3167 Guler,H.-P., Zapf,J., Scheiwiller,E., Froesch,E.R. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc.Natl.Acad.Sci.USA 1988; 85(--):4889-4893. >>> Insulin-like growth factor I; Growth hormone, human; Acetic acid; Saline; SC; rat; 2001; 2002; 6-18 days; replacement therapy (hypophysectomy); pumps replaced after 12 days; no stress (see pg. 4889); peptides; pumps placed under abdominal skin; rats given prophylactic dose of oxytetracycline; recomb. human IGF-1 used.

P3166 Schoenie,E., Zapf,J., Humbel,R.E., Froesch,E.R. Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 1982; 296(--):252-253. >>> Insulin-like growth factor I; Growth hormone, human; Acetic acid; Saline; SC; rat; 2001; 6 days; replacement therapy (hypophysectomy); comparison of HGH injections vs. mp; stability verified for 6 days by RIA; peptides.

P3098 Wells,T., Mode,A., Floby,E., Robinson,I.C.A.F. The sensitivity of hepatic CYP2C gene expression to baseline growth hormone (GH) bioactivity in dwarf rats: effects of GH-binding protein in vivo. Endocrinology 1994; 134(-5-):2135-2141. >>> Growth hormone, recomb. human; Saline; SC; rat; 2001; 6 days; replacement therapy (dwarf rats used); comparison of pulsed infusion pump vs. mp; peptides.

P3008 Freyschuss,B., Sahlin,L., Masironi,B., Eriksson,H. The hormonal regulation of the oestrogen receptor in rat liver: an interplay involving growth hormone, thyroid hormones and glucocorticoids. J.Endocrinol. 1994; 142(--):285-298. >>> Growth hormone, human; Triiodothyronine, L-; Prolactin, ovine; Dexamethasone; SC; rat; 7 days; controls received hypophysectomy only w/ no mp; functionality of mp verified by checking pumps after usage; replacement therapy (hypophysectomy); comparison of single sc injections of GH&T3 vs. mp; agents given alone or in combination; growth hormone via mp partly restores liver estrogen receptor concentration while same dose in 2 single injections daily has no effect.

P2947 Sato,M., Frohman,L.A. Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats. Endocrinology 1993; 133(-2-):793-799. >>> Growth hormone, recomb. human; Insulin-like growth factor I; Saline, sterile; SC; CSF/CNS; rat; 1003D; 7 days; controls received mp with saline; functionality of mp verified by residual volume; replacement therapy (GH-deficient dwarf rats used); comparison of sc injections vs. mp; peptides; recomb. human IGF-1 used.

P2946 Sato,M., Murao,K., Niimi,M., Tamaki,M., Takahara,J. Effects of long-term infusion of growth hormone (GH)-releasing factor on pulsatile GH secretion in the male rat. Life Sci. 1993; 54(-2-):79-86. >>> Growth hormone-rel. factor (1-44) -NH2, human; IV (femoral); rat; 2002; 14 days; comparison of acute infusion vs. mp; peptides; pumps placed near abdomen.

P2944 Schlechter,N.L., Katz,L.S., Russell,S.M., Nicoll,C.S. Physiological evaluation of the role of the liver as a mediator of the growth-promoting action of somatotrophin. Zoological Science 1993; 10(--):235-244. >>> Growth hormone, human; Growth hormone, bovine; Growth hormone, rat; IV (jugular); IV (portal); rat; 2001; 7 Days; controls received mp with solvent or sham operation; replacement therapy (hypophysectomy); pulsed delivery; catheter contained heparin.

P2928 Rudling,M., Norstedt,G., Olivecrona,H., Reihner,E., Gustafsson,J.-A., Angelin,B. Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc.Natl.Acad.Sci.USA 1992; 89(--):6983-6987. >>> Growth hormone, human; Dexamethasone; Thyroxine, l-; SC; rat; 2001; 5 days; replacement therapy (hypophysectomy); peptides; GH given solely, or GH/Dex, GH/Dex/T4, or Dex/T4.

P2897 Peter,M.A., Winterhalter,K.H., Boni-Schnetzler,M., Froesch,E.R., Zapf,J. Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue. Endocrinology 1993; 133(--):2624-2631. >>> Insulin-like growth factor I; Growth hormone, recomb. human; Acetic acid; NaCl; Water; SC; rat; 6 days; controls received mp with solvent; replacement therapy (hypophysectomy); peptides; pumps implanted abdominally; recomb. human IGF-1 used.

P2891 Oinonen,T., Nikkola,E., Lindros,K.O. Growth hormone mediates zone-specific gene expression in liver. FEBS Lett. 1993; 327(-2-):237-240. >>> Growth hormone, recomb. human; SC; rat; 1701; 7 days; controls received mp with saline; replacement therapy (hypophysectomy); peptides.

P2795 Gabrielsson,B.G., Carmignac,D.F., Flavell,D.M., Robinson,I.C.A.F. Steroid regulation of growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids in the rat. Endocrinology 1995; 136(--):209-217. >>> Growth hormone, recomb. human; SC; rat; 7, 12 or 14 days; no comment posted.

P2667 Carmignac,D.F., Gabrielsson,B.G., Robinson,I.C.A.F. Growth hormone binding protein in the rat: effects of gonadal steroids. Endocrinology 1993; 133(-6-):2445-2452. >>> Growth hormone, human; SC; rat; 7,12,14 days; peptides.

P2427 Schlechter,N.L., Russell,S.M., Spencer,E.M., Nicoll,C.S. Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc.Natl.Acad.Sci. 1986; 83(--):7932-7934. >>> Growth hormone, rat; Somatomedin C, human; Serum, rabbit; Antiserum, human somatomedin C, rabbit; Glycerol; Sodium azide; Water, double-distilled; Sodium heparin; IA (right superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); peptides; minipump and catheter were implanted in abdominal cavity; some rats received co-infusion of GH and rabbit serum or antiserum.

P2359 Meseguer,A., Catterall,J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol.and Cellular Endocrin. 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; 7 days; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

P2163 Cronin,M., Battersby,J., Hancock,W., Schwall,T., Clark,R. Delivery of recombinant human growth hormone to rats during exposure to microgravity on NASA space shuttle discovery. Physiologist 1992; 35(-1-):S51-S52. >>> Growth hormone, recomb. human; F68 detergent; Phosphate; SC; rat; 5 days; functionality of mp verified upon removal by immunoassay; peptides; mp performed well in microgravity; spaceflight.

P1776 Skottner,A., Clark,R.G., Robinson,I.C.A.F., Fryklund,L. Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats. J.Endocrinol. 1987; 112(--):123-132. >>> Growth hormone, human; Insulin-like growth factor I; SC; rat; 2001; 6, 8 days; comparison of iv and sc bid injections vs. mp.

P1752 Kashimata,M., Hiramatsu,M., Minami,N. Differential secretory rhythm of growth hormone controls the number of hepatic epidermal growth factor receptors in the rat. J.Endocrinol. 1989; 123(--):75-81. >>> Growth hormone, human; Water; SC; rat; 7 days; replacement therapy (hypophysectomy); comparison of twice daily injections vs. mp; peptides.

P1748 Ng,F.M., Adamafio,N.A., Graystone,J.E. Effects of exogenous growth hormone on lipid metabolism in the isolated epididymal fat pad of the growth hormone-deficient little mouse. J.Mol.Endocrinology 1990; 4(--):43-49. >>> Growth hormone, human; Saline; SC; mice; 2001; 2, 4, 8 days; replacement therapy (genetic GH deficiency); peptides.

P1710 Bick,T., Amit,T., Barkey,R.J., Hertz,P., Youdim,M.B.H., Hochberg,Z. The interrelationship of growth hormone (GH), liver membrane GH receptor, serum GH-binding protein activity, and insulin-like growth factor I in the male rat. Endocrinology 1990; 126(-4-):1914-1920. >>> Growth hormone, human; SC; rat; 2001; 6 days; tissue perfusion (graphs, p. 1916-7); replacement therapy (hypophysectomy).

P1680 Carmignac,D.F., Robinson,I.C.A.F. Growth hormone (GH) secretion in the dwarf rat: release, clearance and responsiveness to GH-releasing factor and somatostatin. J.Endocrinol. 1990; 127(--):69-75. >>> Growth hormone, recomb. human; rat; 1 week; controls received teflon rods 'as minipump blanks' (p. 71).

P1663 Jansson,J.-O., Oscarsson,J., Mode,A., Ritzen,E.M. Plasma growth hormone pattern and androgens influence the levels of corticosteroid-binding globulin in rat serum. J.Endocrinol. 1989; 122(--):725-732. >>> Growth hormone, bovine; Growth hormone, human; Glycerol; PBS; Sodium azide; SC; rat; 2001; no duration posted; controls received pumps with bGH vehicle (PB, glyc., sod. az.); dose-response table (p. 727); comparison of sc injections vs. mp; 'results demonstrate that continuous GH treatment by osmotic minipumps enhances the serum concentration of CBG...whereas inte.

P1566 Kanje,M., Skottner,A., Lundborg,G. Effects of growth hormone treatment on the regeneration of rat sciatic nerve. Brain Research 1988; 475(--):254-258. >>> Growth hormone, human; Water; SC; rat; 2001; 3, 4, 6 days; controls included pump with vehicle and no pump; peptides.

P1479 Zapf,J., Hauri,C., Waldvogel,M., Futo,E., Hasler,H., Binz,K., Guler,H.P., Schmid,C., Froesch,E.R. Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats. Proc.Natl.Acad.Sci. 1989; 86(--):3813-3817. >>> Growth hormone, recomb. human; Insulin-like growth factor I; Acetic acid; Saline; SC; rat; 2001; 2002; 6, 8 days; 8, 16, 48 hours; replacement therapy (hypophysectomy); peptides.

P1478 Waxman,D.J., Morrissey,J.J., LeBlanc,G.A. Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. Endocrinology 1989; 124(-6-):2954-2966. >>> Growth hormone, bovine; Growth hormone, human; SC; rat; 2001; 7 days; replacement therapy (hypophysectomy); stability tested by SDS-PAGE analysis of residue.

P1422 Yamazoe,Y., Shimada,M., Murayama,N., Kato,R. Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J.Biol.Chem. 1987; 262(-15-):7423-7428. >>> Growth hormone, human; Prolactin, ovine; SC; rat; 2001; 7 days; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1375 Oscarsson,J., Jansson,J.-O., Eden,S. Plasma pattern of growth hormone regulates sexual differentiation of phosphatidylcholine in rat plasma. Acta Physiol.Scand. 1988; 133(--):257-265. >>> Growth hormone, human; Prolactin, ovine; Saline; SC; rat; 2001; 7 days; controls received sham surgery; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1342 Kurtz,A., Zapf,J., Eckardt,K., Clemons,G., Froesch,E. Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats. Proc.Natl.Acad.Sci. 1988; 85(--):7825-7829. >>> Growth hormone, human; Insulin-like growth factor I; Saline; SC; rat; 2001; 6 days; functionality of mp verified by serum levels; replacement therapy (hypophysectomy); peptides.

P1336 Oscarsson,J., Eden,S. Sex differences in fatty acid composition of rat liver phosphatidylcholine are regulated by the plasma pattern of growth hormone. Biochim.Biophys.Acta 1988; 959(--):280-287. >>> Growth hormone, bovine; Growth hormone, human; Prolactin, ovine; Glycerol; PBS; Saline; Sodium azide; Water; SC; rat; 2001; 6 days; comparison of sc injections 2x daily vs. mp infusion; replacement therapy (gonadectomy and hypophysectomy); peptides.

P1286 Strom,A., Mode,A., Zaphiropoulos,P., Nilsson,A.-G., Morgan,E., Gustafsson,J.-A. Cloning and pretranslational hormonal regulation of testosterone 16a-hydroxylase(p-45016a) in male rat liver. Acta Endocrinol. 1988; 118(--):314-320. >>> Growth hormone, bovine; Growth hormone, human; SC; rat; 7 days; comparison of sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1269 Elam,M.B., Simkevich,C.P., Solomon,S.S., Wilcox,H.G., Heimberg,M. Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo. Endocrinology 1988; 122(-4-):1397-1402. >>> Cortisol; Growth hormone, human; Triiodothyronine; Sodium hydroxide; Saline; SC; rat; 7, 14 days; pump model not stated; male rats infused for 7 days, females for 14; agents infused separately; replacement therapy (hypophysectomy); peptides.

P1190 Mehls,O., Ritz,E., Hunziker,E.-B., Eggli,P., Heinrich,U., Zapf,J. Improvement of growth and food utilization by human recombinant growth hormone in uremia. Kidney Int. 1987; 33(-1-):45-52. >>> Growth hormone, human; Water; SC; rat; 2ML1; 2 weeks; controls received mp w/ water; dose-response (table); comparison of ip injections vs. mp infusion; peptides.

P1130 Carlsson-Bostedt,L., Frohlander,N., Eden,S., Stigbrand,T., von Schoultz,B. Effects of oestrogen and human growth hormone on pregnancy-associated plasma proteins in the rat. Acta Endocrinol. 1987; 116(--):299-304. >>> Estradiol, 17B-; Growth hormone, human; Ethanol; Glycerol; Saline; Water; SC; rat; 2002; 12 days; controls received mp w/ saline; saline is vehicle for hGH; concomitant and simultaneous infusion of agents; peptides.

P1094 Quail,J.A., Jellinck,P.H. Modulation of catechol estrogen synthesis by rat liver microsomes: Effects of treatment with growth hormone or testosterone. Endocrinology 1987; 121(--):987-992. >>> Growth hormone, bovine; Growth hormone, human; Growth hormone, ovine; Growth hormone, rat; Saline; Sodium bicarbonate; SC; rat; 2001; 7 days; GH, in some cases dissolved in sodium bicarbonate; agents infused separately; peptides.

P1027 Ader,M, Agajanian,T., Finegood,D.T., Bergman,R.N. Recombinant deoxyribonucleic acid-derived 22K- and 20K-human growth hormone generate equivalent diabetogenic effects during chronic infusion in dogs. Endocrinology 1987; 120(-2-):725-731. >>> Growth hormone, human; SC; dog; 2ML2; 12 days; pumps primed in sterile water overnight before implantation; functionality of mp verified upon removal.

P1005 Norstedt,G., Husman,B., Mode,A., Eneroth,P., Lewis,U.J., Gustafsson,J.-A. Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides. Acta Endocrinol. 1987; 114(--):350-356. >>> Prolactin, human; Growth hormone, bovine; Growth hormone, human; Growth hormone, rat; Lactogen, human placental; Prolactin, ovine; Prolactin, rat; 125I tracer; Saline; Sodium bicarbonate; Sodium carbonate; Tris buffer; SC; rat; 2001; 2ML1; 1 week; mp w/vehicle; peptides; replacement therapy (hypophysectomy).

P0981 Nilsson,A., Isgaard,J., Lindahl,A., Peterson,L., Isaksson,O. Effects of unilateral arterial infusion of GH and IGF-I on tibial longitudinal bone growth in hypophysectomized rats. Calcif.Tissue Int. 1987; 40(-2-):91-96. >>> Growth hormone, human; Insulin-like growth factor I; Prolactin, ovine; Saline, heparinized; IA (femoral); rat; 2002; 14 days; controls were untreated; mp connected to catheter in femoral artery; replacement therapy (hypophysectomy); local IA infusion; peptides.

P0859 Jeffery,S., Wilson,C.A., Mode,A., Gustafsson,J.-A., Carter,N.D. Effects of hypophysectomy and growth hormone infusion on rat hepatic carbonic anhydrases. J.Endocrinol. 1986; 110(--):123-126. >>> Growth hormone, human; rat; 2ML2; 7 days; replacement therapy (hypophysectomy); peptides.

P0842 Blanck,A., Astrom,A., Hansson,T., De Pierre,J.W., Gustafsson,J.-A. Pituitary regulation of cytochrome P-450-mediated metabolism of steroids and xenobiotics in rat liver microsomes. Carcinogenesis 1986; 7(-4-):575-582. >>> Growth hormone, human; SC; rat; 2001; 1 week; replacement therapy (hypophysectomy); cancer; peptides.

P0802 Chatterjee,B., Demyan,W.F., Gustafsson,J.-A., Harris,M.W., Hokfelt,T., Norstedt,G., Roy,A.K. Effect of anterior hypothalmic deafferentation and continuous growth hormone infusion on the hepatic synthesis of a2u-globulin in the male rat. J.Endocrinol. 1986; 108(-3-):351-355. >>> Growth hormone, human; Saline; SC; rat; 2001; 1 week; comparison of injections vs. mp infusion; dose-response; peptides.

P0768 Gause,I., Eden,S. Induction of growth hormone (GH) receptors in adipocytes of hypophysectomized rats by GH. Endocrinology 1986; 118(-1-):119-124. >>> Growth hormone, bovine; Growth hormone, human; Saline; SC; rat; 5 or 6 days; comparison of injections vs. mp infusion; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0725 Jellinck,P.H., Quail,J.A., Crowley,C.A. Normal and recombinant human growth hormone administered by constant infusion feminize catechol estrogen formation by rat liver microsomes. Endocrinology 1985; 117(--):2274-2278. >>> Growth hormone, human; Prolactin; Saline; SC; rat; 2001; 5-7 days; peptides.

P0688 MacGeoch,C., Morgan,E.T., Gustafsson,J.-A. Hypothalamo-pituitary regulation of cytochrome P-450(15B) apoprotein levels in rat liver. Endocrinology 1985; 117(-5-):2085-2092. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; SC; rat; 2001; 2ML1; 1 week; comparison of twice daily sc injec of rat GH vs. mp infusion; replacement therapy (hyposphysectomy); controls received sham mp made of silicone; tubing; peptides.

P0667 Dembinski,T.C., Leung,C.K.H., Shiu,R.P.C. Evidence for a novel pituitary factor that potentiates the mitogenic effect of estrogen in human breast cancer cells. Cancer Res. 1985; 45(-7-):3083-3089. >>> Growth hormone, human; Growth hormone, ovine; Prolactin, ovine; mice; 49-56 days; comparison of daily sc injec. vs. mp infusion; comparison of agents effects; long-term study; cancer; peptides.

P0599 Schoenle,E., Zapf,J., Hauri,C., Steiner,T., Froesch,E.R. Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats. Acta Endocrinol. 1985; 108(--):167-174. >>> Growth hormone, human; Insulin-like growth factor I; Insulin-like growth factor II; Acetic acid; Saline; SC; rat; 2001; 6 days; comparison of agents effects; replacement therapy (hypophysectomy); stability of residual IGF1&IGF2 verified by RIA; saline used as vehicle for hGH, acetic acid for IGF; dose-response data; peptides.

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4. Growth Hormone, Ovine

4652 Scanes, C.G., Proudman, J.A, Radecki, S.V. Influence of continuous growth hormone or insulin-like growth factor I administration in adult female chickens.. General and Comparative Endocrinology 1999; 114(--):315-323. >>> Growth hormone, chicken; Insulin-like growth factor I;; Saline; Albumin, bovine serum;; SC;; bird (chicken);; 2ML2;; controls received mp w/vehicle; functionality of mp verified by plasma levels; peptides; recomb. chicken growth hormone used;.

1526 Scanes, C.G., Peterla, T.A., Kantor, S., Ricks, C.A. In vivo effects of biosynthetic chicken growth hormone in broiler-strain chickens. Growth Dev. Aging 1990; 54(--):95-101. >>> Growth hormone, chicken; Albumin, bovine serum; Saline; SC; bird (chicken); 2ML4; pumps were siliconized (probably using Prosil) to decrease protein binding in pumps.

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5. Growth Hormone, Porcine

15054 Nishida, H., Ikegami, A., Kaneko, C., Kakuma, H., Nishi, H., Tanaka, N., Aoyama, M., Usami, M., Okimura, Y., Okimura, Y. Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats. PLoS One 2015; 10(--):U459-U478. >>> Growth hormone, porcine; SC; Rat; 2002; Animal info (Sprague Dawley, 6 weeks old);.

13756 Diaz, M.E., Miquet, J.G., Rossi, S.P., Irene, P.E., Sotelo, A.I., Frungieri, M.B., Turyn, D., Gonzalez, L., Gonzalez, L. GH administration patterns differently regulate epidermal growth factor signaling. Journal of Endocrinology 2014; 221(--):309-323. >>> Growth hormone, porcine; SC; Mice; 1007D; Controls received mp w/ saline; animal info (Swiss-Webster, 3-4 months old, 26-30g); functionality of mp verified by plasma levels; comparison of SC injection BID vs mp; toxicology;"The results indicate that sustained delivery systems that allow continuous GH plasma patterns would be beneficial in terms of treatment safety with regard to the actions of GH on EGFR signaling and its promitogenic activity."pg 309.

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6. Growth Hormone, Porcine

Q4548 Nishida,H., Ikegami,A., Kaneko,C., Kakuma,H., Nishi,H., Tanaka,N., Aoyama,M., Usami,M., Okimura,Y., Okimura,Y. Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats. PLoS One 2015; 10(--):U459-U478. >>> Growth hormone, porcine; SC; Rat; 2002; 14 days; Animal info (Sprague Dawley, 6 weeks old);.

Q3456 Diaz,M.E., Miquet,J.G., Rossi,S.P., Irene,P.E., Sotelo,A.I., Frungieri,M.B., Turyn,D., Gonzalez,L., Gonzalez,L. GH administration patterns differently regulate epidermal growth factor signaling. Journal of Endocrinology 2014; 221(--):309-323. >>> Growth hormone, porcine; SC; Mice; 1007D; 5 days; Controls received mp w/ saline; animal info (Swiss-Webster, 3-4 months old, 26-30g); functionality of mp verified by plasma levels; comparison of SC injection BID vs mp; toxicology; "The results indicate that sustained delivery systems that allow continuous GH plasma patterns would be beneficial in terms of treatment safety with regard to the actions of GH on EGFR signaling and its promitogenic activity." pg 309.

P5083 Delhanty,P.J.D., Mesotten,D., McDougall,F., Baxter,R.C. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology 2002; 143(-6-):2445-2448. >>> Growth hormone, human; Growth hormone, porcine;; SC; rat; 24-48 hours; comparison of IP injections vs. mp; peptides; porcine or recomb. human GH used.

P4893 Conlon,M.A., Kita,K. Porcine growth hormone and LongR (3)IGF-I can improve recovery from surgery-induced weight loss in guinea pigs. General and Comparative Endocrinology 2001; 123(--):332-336. >>> Growth hormone, porcine; Insulin-like growth factor I analog; Disodium hydrogen orthophosphate; Acetic acid; SC; guinea-pig; 2001; 7 days; controls received mp w/ vehicle; functonality of mp verified by serum drug levels; dose response (text, graph p. 334-5); peptides; LR3IGF-1 is an IGF-I analog; multiple pumps per animal (2), one containing each solution; pGH was dissolvd in 0.1M disodium hydrogen orthophosphate; L3IGF-1 was dissolved in 0.1 M acetic acid.

P4717 Hausman,G.J., Richardson,R.L, Simmen,F.A. Expression of insulin-like growth factor binding proteins (IGFBPs) before and during the hormone sensitive period of adipose tisue development in the fetal pig.. Growth, Development, and Aging 2000; 64(--):51-67. >>> Growth hormone, recomb. porcine;; pig (fetus);; ; Functionality of mp verified by plasma levels; replacement therapy (hypophysectomy); teratology; peptides; pellets used for thyroxine administration..

P3283 McLaughlin,C.L., Rogan,G.J., Buonomo,F.C., Cole,W.J., Hartnell,G.F., Hudson,S., Kasser,T.R., Miller,M.A., Baile,C.A. Finishing lamb performance responses to bovine and porcine somatotropins administered by ALZET pumps. J.Anim.Sci. 1991; 69(--):4039-4048. >>> Growth hormone, bovine; Growth hormone, porcine; SC; sheep; 6 weeks; controls received no treatment; functionality of mp verified by in vitro testing; long-term study, pumps replaced every 2 weeks; peptides.

P2603 Azain,M.J., Roberts,T.J., Martin,R.J., Kasser,T.R. Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats. J.Anim.Sci. 1995; 73(--):1019-1029. >>> Growth hormone, recomb. porcine; Glycerol; Sodium phosphate; Tween 80; SC; rat; 2002; no duration posted; controls received mp w/ vehicle; dose-response (pg. 1021); comparison of sc injections vs. mp.

P2167 Azain,M.J., Kasser,T.R., Sabacky,M.J., Baile,C.A. Comparison of the growth-promoting properties of daily versus continuous administration of somatotropin in female rats with intact pituitaries. J.Anim.Sci. 1993; 71(--):384-392. >>> Growth hormone, recomb. bovine; Growth hormone, porcine; Sodium bicarbonate; SC; rat; 2ML2; 2ML4; 2,4 weeks; controls received mp w/buffer; functionality of mp verified in vitro using spectrophotometry; dose-response (sc injection vs continuous infusion); pumps replaced at 2 weeks; good methods; peptides; weight gain same between 28-day pump-implanted rats and rats receiving 2 14-day pumps (graph p. 388).

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7. Growth Hormone, Rat

12063 Zhang, Y.J., Laz, E.V., Waxman, D.J. Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver. MOLECULAR AND CELLULAR BIOLOGY 2012; 32(-4-):880-896. >>> Growth hormone, rat, recomb.; Mice; 1007D; Animal info (male, female, CD-1, 7-8 wks old).

10947 Meyer, R.D., Laz, E.V., Su, T., Waxman, D.J. Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5. MOLECULAR ENDOCRINOLOGY 2009; 23(-11-):1914-1926. >>> Growth hormone, recomb. rat, human; Rat; Controls were untreated; animal info (male, Fischer 344, 9-13 wks old); replacement therapy (hypophysectomy).

10706 Blackmore, D.G., Golmohammadi, M.G., Large, B., Waters, M.J., Rietze, R.L. Exercise Increases Neural Stem Cell Number in a Growth Hormone-Dependent Manner, Augmenting the Regenerative Response in Aged Mice. Stem Cells 2009; 27(-8-):2044-2052. >>> Growth hormone, recomb. rat; Saline; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle; cyanoacrylate adhesive; animal info (C57BL/6J 6-8 wks old, female).

10507 Pathipati, P., Surus, A., Williams, C.E., Scheepens, A. Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat. Behavioural Brain Research 2009; 204(-1-):93-101. >>> Growth hormone, rat; NaCl; tween 20; NaHCO3; Na2CO3; CSF/CNS; Rat; 2002; Controls received mp w/ vehicleanimal info (adult, male, Sprague-Dawley, 280-350 g); pumps replaced every 2 weeks; stability verified by for 2 weeks in vitro.

10314 Zhao, T.J., Liang, G.S., Li, R.L., Xie, X.F., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., Brown, M.S. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-16-):7467-7472. >>> Ghrelin, recomb. rat; growth hormone, recomb. rat; Saline; sodium bicarbonate; albumin, rat; SC; Mice; 1002; 2004; Controls received mp w/ vehicle; peptides; animal info (male, wt, Goat-/-, 8 weeks old).

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8. Growth Hormone, Rat

Q1792 Zhang,Y.J., Laz,E.V., Waxman,D.J. Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver. MOLECULAR AND CELLULAR BIOLOGY 2012; 32(-4-):880-896. >>> Growth hormone, rat, recomb.; Mice; 1007D; 7 days; Animal info (male, female, CD-1, 7-8 wks old).

Q0698 Meyer,R.D., Laz,E.V., Su,T., Waxman,D.J. Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5. MOLECULAR ENDOCRINOLOGY 2009; 23(-11-):1914-1926. >>> Growth hormone, recomb. rat, human; Rat; 7 days; Controls were untreated; animal info (male, Fischer 344, 9-13 wks old); replacement therapy (hypophysectomy).

Q0457 Blackmore,D.G., Golmohammadi,M.G., Large,B., Waters,M.J., Rietze,R.L. Exercise Increases Neural Stem Cell Number in a Growth Hormone-Dependent Manner, Augmenting the Regenerative Response in Aged Mice. Stem Cells 2009; 27(-8-):2044-2052. >>> Growth hormone, recomb. rat; Saline; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle; cyanoacrylate adhesive; animal info (C57BL/6J 6-8 wks old, female).

Q0258 Pathipati,P., Surus,A., Williams,C.E., Scheepens,A. Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat. Behavioural Brain Research 2009; 204(-1-):93-101. >>> Growth hormone, rat; NaCl; tween 20; NaHCO3; Na2CO3; CSF/CNS; Rat; 2002; 6 weeks; Controls received mp w/ vehicleanimal info (adult, male, Sprague-Dawley, 280-350 g); pumps replaced every 2 weeks; stability verified by for 2 weeks in vitro.

Q0177 Moreno,M., Chaves,J.F., Sancho-Bru,P., Ramalho,F., Ramalho,L.N., Mansego,M.L., Ivorra,C., Dominguez,M., Conde,L., Millan,C., Mari,M., Colmenero,J., Lozano,J.J., Jares,P., Vidal,J., Forns,X., Arroyo,V., Caballeria,J., Gines,P., Bataller,R. Ghrelin Attenuates Hepatocellular Injury and Liver Fibrogenesis in Rodents and Influences Fibrosis Progression in Humans. Hepatology 2010; 51(-3-):974-985. >>> Ghrelin, recomb. rat; growth hormone releasing peptide-2, Des-Ala3-; Saline; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; no stress (see pg. 975); peptides; animal info (male, Wistar, 250 g, bile duct ligation, acute liver injury); hepatology; GHRP-2 is a ghrelin receptor agonist.

P9969 Zhao,T.J., Liang,G.S., Li,R.L., Xie,X.F., Sleeman,M.W., Murphy,A.J., Valenzuela,D.M., Yancopoulos,G.D., Goldstein,J.L., Brown,M.S. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-16-):7467-7472. >>> Ghrelin, recomb. rat; growth hormone, recomb. rat; Saline; sodium bicarbonate; albumin, rat; SC; Mice; 1002; 2004; 10, 11 days; Controls received mp w/ vehicle; peptides; animal info (male, wt, Goat-/-, 8 weeks old).

P9628 Loefgren,S., Baldwin,R.M., Carleroes,M., Terelius,Y., Fransson-Steen,R., Mwinyi,J., Waxman,D.J., Ingelman-Sundberg,M. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone. Drug Metabolism and Disposition 2009; 37(-7-):1505-1512. >>> Growth hormone, recomb, rat; NaHCO3; albumin, rat; NaCl; SC; Mice (transgenic); 1007D; 4, 7 days; Animal info (CYP2C18/CYP2C19, wt, male, 8-11 wks old).

P7932 Zeinoaldini,S., Swarts,H.J.M., Van de Heijning,B.J.M. Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat. REGULATORY PEPTIDES 2006; 134(-2-3-):158-163. >>> Growth hormone, recomb. human; immunoglobulin G, goat; growth hormone, anti-rat; Saline, sterile; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; post op. care (analgesia, ibuprofen); animal info (female, Wistar, 45 grams).

P7903 Holloway,M.G., Laz,E.V., Waxman,D.J. Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4 alpha. MOLECULAR ENDOCRINOLOGY 2006; 20(-3-):647-660. >>> Growth hormone, recomb. rat; Saline; albumin, rat; sodium bicarbonate; SC; Mice; 1003D; 1007D; 1002; 1,2,4,7,14 days; 10 hours; Controls received mp w/ vehicle; peptides; animal info (male, female, ICR, 8-10 wk. old).

P6848 Kamegai,J., Tamura,H., Shimizu,T., Ishii,S., Tatsuguchi,A., Sugihara,H., Oikawa,S., Kineman,R.D. The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology 2004; 145(-8-):3731-3738. >>> Growth hormone, rat; insulin-like growth factor-1, recomb. human; Saline; SC; Rat; 1003D; 72 hours; Controls received mp w/ vehicle; peptides.

P6509 Ahluwalia,A., Clodfelter,K.H., Waxman,D.J. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. MOLECULAR ENDOCRINOLOGY 2004; 18(-3-):747-760. >>> Growth hormone, rat; Rat; 7 days; Controls received no treatment; peptides; pump model not listed.

P5826 Obal,F.Jr, Alt,J., Taishi,P., Gardi,J., Krueger,J.M. Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-1-):R131-R139. >>> Growth hormone, mouse; growth hormone, rat; Saline; SC; Mice; 1002; 14 days; Functionality of mp verified by IGF-1 plasma levels; peptides.

P5590 Gevers,E.F., Loveridge,N., Robinson,I.C.A.F. Bone marrow adipocytes: A neglected target tissue for growth hormone. Endocrinology 2002; 143(-10-):4065-4073. >>> Growth hormone; Insulin-like growth factor I; Parathyroid hormone (1-34); BSA; water; SC; rat; 2002; 2 weeks; replacement therapy (genetically GH-deficient rats); peptides.

P4423 Kamegai,J, Unterman,T.G, Frohman,L.A, Kineman,R.D. Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormome (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid. Endocrinology 1998; 139(--):3554-3560. >>> Growth hormone, rat; Insulin-like growth factor I;; Saline;; SC;; rat;; 1003D;; 72 hours;; controls received mp w/vehicle; functionality of mp verified by serum levels; recomb. human IGFI used;.

P3963 Pampori,N.A., Shapiro,B.H. Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. Mol.Pharmacol. 1996; 50(--):1148-1156. >>> Growth hormone, rat; Thyroxine; SC; IP; rat; 6 days; functionality of mp verified by residual volume; replacement therapy (hypophysectomy); peptides; multiple pumps per animal (2) (1 with each agent).

P3258 Labrie,Y., Couet,J., Simard,J., Labrie,F. Multihormonal regulation of dehydroepiandrosterone sulfotransferase messenger ribonucleic acid levels in adult rat liver. Endocrinology 1994; 134(-4-):1693-1699. >>> Growth hormone, rat; Saline; SC; rat; 2001; 7 days; replacement therapy (hypophysectomy); comparison of injections vs. mp; peptides.

P3162 Hursting,S.D., Switzer,B.R., French,J.E., Kari,F.W. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis 1994; 15(-2-):193-199. >>> Growth hormone, rat; Saline; BSA; SC; rat; 2001; no duration posted; controls received mp with saline; cancer; toxicology; peptides.

P2944 Schlechter,N.L., Katz,L.S., Russell,S.M., Nicoll,C.S. Physiological evaluation of the role of the liver as a mediator of the growth-promoting action of somatotrophin. Zoological Science 1993; 10(--):235-244. >>> Growth hormone, human; Growth hormone, bovine; Growth hormone, rat; IV (jugular); IV (portal); rat; 2001; 7 Days; controls received mp with solvent or sham operation; replacement therapy (hypophysectomy); pulsed delivery; catheter contained heparin.

P2427 Schlechter,N.L., Russell,S.M., Spencer,E.M., Nicoll,C.S. Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc.Natl.Acad.Sci. 1986; 83(--):7932-7934. >>> Growth hormone, rat; Somatomedin C, human; Serum, rabbit; Antiserum, human somatomedin C, rabbit; Glycerol; Sodium azide; Water, double-distilled; Sodium heparin; IA (right superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); peptides; minipump and catheter were implanted in abdominal cavity; some rats received co-infusion of GH and rabbit serum or antiserum.

P2359 Meseguer,A., Catterall,J.F. Effects of pituitary hormones on the cell-specific expression of the KAP gene. Mol.and Cellular Endocrin. 1992; 89(--):153-162. >>> Luteinizing hormone; ACTH, human; Thyroid-stimulating hormone, rat; Follicle stimulating hormone, rat; Growth hormone, rat; Prolactin, ovine; SC; mice; 2001; 7 days; controls received mp w/ vehicles; replacement therapy (hypophysectomy); peptides.

P1459 MacLeod,J.N., Shapiro,B.H. Growth hormone regulation of hepatic drug-metabolizing enzymes in the mouse. Biochem.Pharmacol. 1989; 38(-10-):1673-1677. >>> Growth hormone, rat; Sodium bicarbonate; Sodium chloride; Water; SC; mice; 2001; 7 days; dose-response; comparison of sc injections vs. mp infusion; functionality of mp verified in vitro by RIA; replacement therapy (hypophysectomy); peptides.

P1426 Orlowski,C.C., Chernausek,S.D. Discordance of serum and tissue somatomedin levels in growth hormone-stimulated growth in the rat. Endocrinology 1988; 123(-1-):44-49. >>> Growth hormone, rat; Saline; Serum, rat; Sodium bicarbonate; SC; rat; 2001; 4 days; controls received sham surgery; comparison of 2x daily sc injections vs. mp infusion; replacement therapy (hypophysectomy); peptides.

P1330 Maiter,D., Underwood,L.E., Maes,M., Davenport,M.L., Ketelslegers,J.M. Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor 1 and liver GH receptors in hypophysectomized rats. Endocrinology 1988; 123(-2-):1053-1059. >>> Growth hormone, rat; Saline; SC; rat; 2001; 7 days; dose-response (graph); comparison of sc injections vs. mp infusion; functionality of mp verified by serum levels; replacement therapy (hypophysectomy); peptides.

P1094 Quail,J.A., Jellinck,P.H. Modulation of catechol estrogen synthesis by rat liver microsomes: Effects of treatment with growth hormone or testosterone. Endocrinology 1987; 121(--):987-992. >>> Growth hormone, bovine; Growth hormone, human; Growth hormone, ovine; Growth hormone, rat; Saline; Sodium bicarbonate; SC; rat; 2001; 7 days; GH, in some cases dissolved in sodium bicarbonate; agents infused separately; peptides.

P1005 Norstedt,G., Husman,B., Mode,A., Eneroth,P., Lewis,U.J., Gustafsson,J.-A. Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides. Acta Endocrinol. 1987; 114(--):350-356. >>> Prolactin, human; Growth hormone, bovine; Growth hormone, human; Growth hormone, rat; Lactogen, human placental; Prolactin, ovine; Prolactin, rat; 125I tracer; Saline; Sodium bicarbonate; Sodium carbonate; Tris buffer; SC; rat; 2001; 2ML1; 1 week; mp w/vehicle; peptides; replacement therapy (hypophysectomy).

P0977 Tatro,J.B., Schwartz,J. Metabolic effects of acute and prolonged growth hormone deficiency in streptozotocin-diabetic rats. Endocrinology 1987; 120(--):373-380. >>> Growth hormone, anti-rat; Nonimmunized sera; IP; rat; 2ML1; 5 days; controls received mp w/vehicle; comparison of ip injections vs. mp infusion; peptides.

P0895 Scott,C.D., Baxter,R.C. Production of insulin-like growth factor I and its binding protein in rat hepatocytes cultured from diabetic and insulin-treated diabetic rats. Endocrinology 1986; 119(-5-):2346-2352. >>> Growth hormone, rat; Insulin; SC; rat; 2001; 2002; up to 14 days; controls were untreated; peptides.

P0771 Schlechter,N.L., Russell,S.M., Greenberg,S., Spencer,E.M., Nicoll,C.S. A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion. Am.J.Physiol. 1986; 250(--):E231-E235. >>> Growth hormone, rat; Prolactin, ovine; Glycerol; Sodium azide; IA (superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); mp connected to catheter in superior vesicle artery; detailed description and diagram of catheter apparatus; constant and pulsed delivery of GH; peptides.

P0688 MacGeoch,C., Morgan,E.T., Gustafsson,J.-A. Hypothalamo-pituitary regulation of cytochrome P-450(15B) apoprotein levels in rat liver. Endocrinology 1985; 117(-5-):2085-2092. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; SC; rat; 2001; 2ML1; 1 week; comparison of twice daily sc injec of rat GH vs. mp infusion; replacement therapy (hyposphysectomy); controls received sham mp made of silicone; tubing; peptides.

P0581 Scott,C.D., Martin,J.L., Baxter,R.C. Rat hepatocyte insulin-like growth factor I and binding protein: effect of growth hormone in vitro and in vivo. Endocrinology 1985; 116(-3-):1102-1107. >>> Growth hormone, rat; SC; rat; 2001; 5 days; replacement therapy (hypophysectomy); peptides.

P0535 Baxter,R.C., Zaltsman,Z. Induction of hepatic receptors for growth hormone (GH) and prolactin by GH infusion is sex independent. Endocrinology 1984; 115(-5-):2009-2014. >>> Growth hormone, rat; Prolactin, rat; SC; rat; 1 week; comparison of agents effects; replacement therapy (hypophysectomy); peptides.

P0483 Norstedt,G., Andersson,G., Gustafsson,J.-A. Growth hormone induction of lactogenic receptors at intracellular sites in male rat liver. Endocrinology 1984; 115(-2-):672-680. >>> Growth hormone, human; Growth hormone, rat; SC; rat; 2001; 2ML1; 1-7 days; replacement therapy (hypophysectomy); hGH used in 2001 mp, rGH used in 2ML1; peptides.

P0450 Baxter,R.C., Zaltsman,Z., Turtle,J.R. Rat growth hormone (GH) but not prolactin (PRL) induces both GH and PRL receptors in female rat liver. Endocrinology 1984; 114(-5-):1893-1901. >>> Growth hormone, ovine; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; comparison of agents effects; peptides.

P0230 Skett,P., Young,C. The effects of pituitary hormones on hepatic drug metabolism in the rat. Acta Endocrinol. 1982; 100(--):421-426. >>> Follitropin, rat; Thyrotropin, rat; Growth hormone, human; Growth hormone, rat; Pituitary extract; Prolactin, rat; Saline; Water; SC; rat; 1701; 6 days; organ replacement therapy (hypophysectomy); agents also injected - comparison of injec vs. mp infusion; peptides.

P0226 Schoenle,E., Zapf,J., Froesch,E.R. Glucose transport in adipocytes and its control by growth hormone in vivo. Am.J.Physiol. 1982; 242(--):E368-E372. >>> Growth hormone, human; Growth hormone, rat; Saline; SC; rat; 2001; 6 days; comparison of sc injec. vs. sc infusion; organ replacement therapy (hypophysectomy); peptides.

P0215 Norstedt,G. A comparison between the effects of growth hormone on prolactin receptors and estrogen receptors in rat liver. Endocrinology 1982; 110(-6-):2107-2112. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 1 week; organ replacement therapy (hypophysectomy); intermittent injections vs. infusion; peptides.

P0212 Pousette,A., Bjork,P., Carlstrom,K., Forsgren,B., Hogberg,B., Gustafsson,J.-A. Influence of pituitary and adrenocortical hormones on prostatic secretion protein, a major protein in rat prostate. The Prostate 1982; 3(--):109-114. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 2 weeks; replacement therapy (hypophysectomy); peptides.

P0148 Gustafsson,J.-A., Eneroth,P., Hokfelt,T., Mode,A., Norstedt,G., Skett,P. Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents. Environ.Health Perspect. 1981; 38(--):129-141. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; SC; rat; 7 days; replacement therapy (hypophysectomy); toxicology; peptides.

P0133 Mode,A., Norstedt,G., Simic,B., Eneroth,P., Gustafsson,J.-A. Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat. Endocrinology 1981; 108(-6-):2103-2108. >>> Growth hormone, human; Growth hormone, rat; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

P0126 Norstedt,G., Mode,A., Eneroth,P., Gustafsson,J.-A. Induction of prolactin receptors in rat liver after the administration of growth hormone. Endocrinology 1981; 108(-5-):1855-1861. >>> Growth hormone, human; Growth hormone, rat; Prolactin, ovine; Prolactin, rat; Sodium hydroxide; Saline; SC; rat; 7 days; replacement therapy (hypophysectomy, adrenalectomy); peptides.

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9. Growth Hormone-rel. Factor

15825 Veronique St-Onge, AlexanderWatts, Alfonso Abizaid. Ghrelin enhances cue-induced bar pressing for high fat food. Horm. Behav 2016; 78(--):141-149. >>> Ghrelin; growth hormone-releasing peptide 6, [D-Lys-3]; Saline; CSF/CNS (ventral tegmental area); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Long evans, 216-375g); post op. care (SC injection of meloxicam; feed of mashed food); behavioral testing (food operant responses); used Plastics One cannula; obesity;.

14742 Garcia-Caceres, C., Fuente-Martin, E., Diaz, F., Granado, M., rgente-Arizon, P., Frago, L.M., Freire-Regatillo, A., Barrios, V., Argente, J., Chowen, J.A., Chowen, J.A. The Opposing Effects of Ghrelin on Hypothalamic and Systemic Inflammatory Processes Are Modulated by Its Acylation Status and Food Intake in Male Rats. Endocrinology 2014; 155(--):2868-2880. >>> Ghrelin, acylated; ghrelin, non-acylated; ghrelin mimetic growth hormone-releasing peptide-6; Saline; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 250g); immunology;.

10620 Sheriff, S., Joshi, R., Friend, L.A., James, J.H., Balasubramaniam, A. Ghrelin receptor agonist, GHRP-2, attenuates burn injury-induced MuRF-1 and MAFbx expression and muscle proteolysis in rats. Peptides 2009; 30(-10-):1909-1913. >>> Growth hormone-releasing peptide-2; SC; Rat; 2001D; Controls received mp w/ saline; animal info (male, Sprague Dawley, 50-70 g); peptides.

9135 Fiorotto, M.L., Lopez, R., Oliver, W.T., Khan, A.S., Draghia-Akli, R. Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. DNA and Cell Biology 2006; 25(-8-):429-437. >>> Growth hormone-releasing hormone; radio-isotopes 125I tracer; BSA; SC; Rat (pregnant); 1003D; Controls received sham operation; functionality of mp verified by residual volume, total activity; no stress (see pg. 433); half-life (p. 432) 8 hours; teratology; peptides; animal info (female, Sprague Dawley, gd18).

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10. Growth Hormone-rel Factor

Q3936 Kemp,B.A., Howell,N.L., Gildea,J.J., Padia,S.H., Padia,S.H. Intrarenal Ghrelin Receptor Antagonism Prevents High-Fat Diet-Induced Hypertension in Male Rats. Endocrinology 2014; 155(--):2658-2666. >>> Growth hormone releasing peptide, D-Lys3; SUB-P; Dextrose; water; Kidney (renal cortex); Rat; 2001; 2004; 1 week; 8 weeks; Controls received mp w/ vehicle; animal info (male, Dahl salt-sensitive, 6 weeks old); pumps replaced every 4 weeks; long-term study; cardiovascular; peptides; used PE-10 catheter tubing; BP measured using radiotelemetry (DSI); D-LYS is a GHSR antagonist; SUB-P is an inverse agonist;.

Q3886 Garcia-Caceres,C., Fuente-Martin,E., Diaz,F., Granado,M., rgente-Arizon,P., Frago,L.M., Freire-Regatillo,A., Barrios,V., Argente,J., Chowen,J.A., Chowen,J.A. The Opposing Effects of Ghrelin on Hypothalamic and Systemic Inflammatory Processes Are Modulated by Its Acylation Status and Food Intake in Male Rats. Endocrinology 2014; 155(--):2868-2880. >>> Ghrelin, acylated; ghrelin, non-acylated; ghrelin mimetic growth hormone-releasing peptide-6; Saline; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle; animal info (male, Wistar, 250g); immunology;.

Q0672 Sato,T., Nakashima,Y., Nakamura,Y., Ida,T., Kojima,M. Continuous Antagonism of the Ghrelin Receptor Results in Early Induction of Salt-Sensitive Hypertension. Journal of Molecular Neuroscience 2011; 43(-2-):193-199. >>> Growth hormone releasing peptide-6; growth hormone releasing peptide-6, D-Lys3; SC; Rat; 2002; 14 days; Controls received mp w/ sterile saline; animal info (DSS, DSR, 6 wks old, male); [D-Lys3]-GHRP-6 is a ghrelin receptor antagonist; GHRP-6 is a ghrelin receptor agonist; peptides.

Q0371 Sheriff,S., Joshi,R., Friend,L.A., James,J.H., Balasubramaniam,A. Ghrelin receptor agonist, GHRP-2, attenuates burn injury-induced MuRF-1 and MAFbx expression and muscle proteolysis in rats. Peptides 2009; 30(-10-):1909-1913. >>> Growth hormone-releasing peptide-2; SC; Rat; 2001D; 1 day; Controls received mp w/ saline; animal info (male, Sprague Dawley, 50-70 g); peptides.

Q0177 Moreno,M., Chaves,J.F., Sancho-Bru,P., Ramalho,F., Ramalho,L.N., Mansego,M.L., Ivorra,C., Dominguez,M., Conde,L., Millan,C., Mari,M., Colmenero,J., Lozano,J.J., Jares,P., Vidal,J., Forns,X., Arroyo,V., Caballeria,J., Gines,P., Bataller,R. Ghrelin Attenuates Hepatocellular Injury and Liver Fibrogenesis in Rodents and Influences Fibrosis Progression in Humans. Hepatology 2010; 51(-3-):974-985. >>> Ghrelin, recomb. rat; growth hormone releasing peptide-2, Des-Ala3-; Saline; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; no stress (see pg. 975); peptides; animal info (male, Wistar, 250 g, bile duct ligation, acute liver injury); hepatology; GHRP-2 is a ghrelin receptor agonist.

P8102 de Celix,A.D.R., Chowen,J.A., Argente,J., Frago,L.M. Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. Journal of Neurochemistry 2006; 99(-3-):839-849. >>> Growth hormone releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 200-250g.).

P7613 Frago,L.M., Paneda,C., Argente,J., Chowen,J.A. Growth hormone-releasing peptide-6 increases insulin-like growth factor-I mRNA levels and activates Akt in RCA-6 cells as a model of neuropeptide Y neurones. Journal of Neuroendocrinology 2005; 17(-11-):701-710. >>> Growth hormone-releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, wistar 200-250 g); ghrelin receptor agonist; peptides.

P6600 Paneda,C., Arroba,A.I., Frago,L.M., Holm,A.M., Romer,J., Argente,J., Chowen,J.A. Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats. NeuroReport 2003; 14(-12-):1633-1635. >>> Growth hormone-rel. peptide-6; IV (external jugular); Rat; 2ML1; 7 days; Controls received mp w/ saline; peptides; GHRP-6 is a synthetic ligand for the ghrelin receptor.

P5580 Frago,L.M., Paneda,C., Dickson,S.L., Hewson,A.K., Argente,J., Chowen,J.A. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology 2002; 143(-10-):4113-4122. >>> Growth hormone; Growth hormone-rel. peptide; IV (jugular); rat; 2001; 7 days; controls received mp with saline; peptides.

P3546 Roh,S-G., Matsunaga,N., Hidaka,S., Hidari,H. Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves. Endocrine J. 1996; 43(-3-):291-298. >>> Growth hormone-rel. factor-2; DMSO; PEG 400; Tween 80; Saline; SC; cattle; 2ML2; 14 days; controls received mp w/ vehicle; peptides; agent also called KP102; multiple pumps per animal (3 or 4); comparison between injections vs. mp.

P2946 Sato,M., Murao,K., Niimi,M., Tamaki,M., Takahara,J. Effects of long-term infusion of growth hormone (GH)-releasing factor on pulsatile GH secretion in the male rat. Life Sci. 1993; 54(-2-):79-86. >>> Growth hormone-rel. factor (1-44) -NH2, human; IV (femoral); rat; 2002; 14 days; comparison of acute infusion vs. mp; peptides; pumps placed near abdomen.

P2214 Stefaneanu,L., Kovacs,K., Horvath,E., Clark,R.G., Cronin,M.J. Effect of intravenous infusion of growth hormone-releasing hormone on the morphology of rat pituitary somatotrophs. Endocr.Pathol. 1993; 4(--):131-139. >>> Growth hormone-rel. factor; Acetate in PBS; IV; rat; 2001; 2ML2; 1 week; controls received mp w/vehicle.

P1742 Godfredson,J.A., Wheaton,J.E., Crooker,B.A., Wong,E.A., Campbell,R.M., Mowles,T.F. Growth performance and carcass composition of lambs infused for 28 days with a growth hormone-releasing factor analogue. J.Anim.Sci. 1990; 68(--):3624-3632. >>> Growth hormone-rel. factor analog; DMSO; Water; SC; sheep; 28 days; functionality of mp verified by measurement of residual volume; pumps replaced weekly; stability in vehicle verified at 37 degrees celsius for 7 days.

P1492 Wheaton,J.E., Al-Raheem,S.N., Godfredson,J.A., Dorn,J.M., Wong,E.A., Vale,W., Rivier,J., Mowles,T.F., Heimer,E.P., Felix,A.M. Use of osmotic pumps for subcutaneous infusion of growth hormone-releasing factors in steers and wethers. J.Anim.Sci. 1988; 66(--):2876-2895. >>> 4SG-29; RO-23-7863; Growth hormone-rel. factor; DMSO; Water; SC; cattle; sheep; 2002; 2ML1; 7 days; functionality of mp verified by plasma levels; peptides.

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11. Somatomedin

P2457 Kirkeby,O.J., Ekeland,A. No effects of local somatomedin C on bone repair: continuous infusion in rats. Acta Orthop.Scand. 1992; 63(-4-):447-450. >>> Somatomedin C; Acetic acid; bone (medulla); rat; 2ML4; no duration posted; tissue perfusion (bone); peptides.

P2427 Schlechter,N.L., Russell,S.M., Spencer,E.M., Nicoll,C.S. Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc.Natl.Acad.Sci. 1986; 83(--):7932-7934. >>> Growth hormone, rat; Somatomedin C, human; Serum, rabbit; Antiserum, human somatomedin C, rabbit; Glycerol; Sodium azide; Water, double-distilled; Sodium heparin; IA (right superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); peptides; minipump and catheter were implanted in abdominal cavity; some rats received co-infusion of GH and rabbit serum or antiserum.

P0196 Rudman,C.G., Parsons,J.A. Autoradiographic comparison of growth factors: influence of growth hormone and somatomedin B on patterns of proline incorporation. Clin.Endocrinol. 1981; 15(--):319-324. >>> Somatomedin B; Growth hormone; HCl; Hexanoic acid, 6-amino-; Water; SC; rat; 1 week; organ replacement therapy (hypophysectomy); peptides.

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12. Somatostatin

R0055 Bloom,S.R., Polak,J.M. The hormonal pattern of intestinal adaptation: a major role for entroglucagon. In 'Basic Science in Gastroenterology: Structure of the Gut,' J.M.Polak, S.R.Bloom, N.A.Wright, and M.J.Daly (eds.), Glaxo Group Research Limited, Ware, UK 1982; (--):409-419. >>> Bombesin; Somatostatin; SC; rat; no duration posted; Comparison of agents effects; see p416-417 for mp experiment; peptides.

P8608 Very,N.M., Sheridan,M.A. Somatostatin regulates hepatic growth hormone sensitivity by internalizing growth hormone receptors and by decreasing transcription of growth hormone receptor mRNAs. American Journal of Physiology- Regulatory, Integrative and Comparative Physiology 2007; 292(-5-):R1956-R1962. >>> Somatostatin-14-I; Saline; IP; Fish (trout); 15 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; peptides; animal info (male, female, juvenile, rainbow trout, 58 grams).

P5015 Kramer,A., Yang,F.C., Snodgrass,P., Li,X., Scammell,T.E., Davis,F.C., Weitz,C.J. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 2001/12/21; 294(-5551-):2511-2515. >>> Transforming growth factor-a; Brain-derived neurotrophic factor; Vasoactive intestinal polypeptide; Peptide, histidine-isoleucine; Gastrin releasing peptide; Substance P; Neuromedin-C; Neurokinin A; Neuropeptide K; Neuropeptide Y; Somatostatin; Antrin; Cholecystokinin; Thyrotropin-releasing hormone; Neurotensin; Neuromedin N;; CSF, artificial; CSF/CNS (third ventricle); hamster; 2002; 18-22 days; peptides.

P4924 de Segura,A.G., Castell,T., Vazquez,I., Mata,A., De Miguel,E. Somatostatin antagonism prevents elemental diet-induced intestinal atrophy in the rat. Digestive Diseases and Sciences 2001; 46(-9-):1985-1992. >>> Somatostatin antagonist; Saline; IP; rat; 2ML1; 7 days; controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; comparison of sc injections vs. mp; peptides; The somatostatin antagonist is cyclo-7-aminoheptanoyl-phe-d-trp-lys-thr (also known as BZL); SC injections examined pulsatile administration of the agent; pump model 2ML1 used (2001 incorrectly listed);.

P2367 Monno,A., Rizzi,M., Samanin,R., Vezzani,A. Anti-somatostatin antibody enhances the rate of hippocampal kindling in rats. Brain Research 1993; 602(-1993-):148-152. >>> Antibody, anti-somatostatin;; PBS; CSF/CNS (dorsal hippocampus); rat; 2002; 30 days; pumps replaced at day 14.

P1943 Stanisz,A.M., Scicchtano,R., Bienenstock,J. The role of vasoactive intestinal peptide and other neuropeptides in the regulation of the immune response in vitro and in vivo. Ann.N.Y.Acad.Sci. 1987; 527(--):478-485. >>> Somatostatin; Substance P; Vasoactive intestinal peptide; SC; mice; 7 days; immunology; peptides.

P1485 Reaven,G.M., Ho,H., Hoffmann,B.B. Somatostatin inhibition of fructose-induced hypertension. Hypertension 1989; 14(--):117-120. >>> Somatostatin analog; Saline; rat; 7 days; peptides.

P1425 Marie,P.J., Hott,M., Durand,D. Somatostatin infusion inhibits the stimulatory effect of testosterone on endosteal bone formation in the mouse. Metabolism 1988; 37(-5-):429-435. >>> Octreotide; Somatostatin; Testosterone propionate; Propylene glycol; SC; mice; 10 days; concomitant infusion of T and SMS from 2 pumps implanted simultaneously; functionality of mp verified after delivery; peptides; somatostatin analog.

P1029 Buonomo,F.C., Sabacky,M.J., Della-Fera,M.A., Baile,C.A. Effects of somatostatin immunoneutralization on growth and endocrine parameters in chickens. Domest.Anim.Endocrinol. 1987; 4(-3-):191-200. >>> Antibody, somatostatin; Saline; Serum, goat; SC; bird (chicken); 2002; 2 weeks; controls received mp w/ saline or goat serum; comparison of bolus inject. vs. IV inject. vs. mp infusion; immunology; peptides.

P0967 Takahashi,Y., Usui,S., Ebihara,S., Honda,Y. Effects of continuous infusions of TRH and GIF on circadian rhythm parameters of sleep, ambulation, eating, and drinking in rats. In 'Endogenous Sleep Substances and Sleep Regulation,' S.Inoue and A.A.Borbely (eds.), Taniguchi Symposia on Brain Sciences 1984; 8(-Ch. 9-):101-112. >>> Somatostatin; Thyrotropin-rel. factor; Saline; CSF/CNS; SC; rat; 2001; no duration posted; mp connected to cannula in ventricle; half-life; rats infused sc and icv simultaneously; stability of agents discussed; peptides.

P0430 Rose,D.P., Gottardis,M., Noonan,J.J. Rat mammary carcinoma regressions during suppression of serum growth hormone and prolactin. Anticancer Res. 1983; 3(--):323-326. >>> L-362823; Somatostatin; Saline; SC; rat; 1 week; comparison of agents effects; simultaeous admin. of pergolide mesylate; cancer hormone therapy; peptides.

P0358 Gavin,L.A., Moeller,M. Glucagon does not modulate the alterations in T3 metabolism consequent to dietary manipulation and diabetes. Diabetes 1983; 32(--):798-803. >>> Glucagon; Somatostatin; Thyroxine; SC; rat; 2001; 2-3 days; separate pumps delivering glucagon and somatostatin were implanted simultaneously in same rat; peptides.

P0243 Holmes,S.J.K., Jaspan,J.B., Moossa,A.R. The effect of somatostatin on postresectional ileal hyperplasia. Endocrinology 1982; 111(-4-):1397-1399. >>> Somatostatin; SC; rat; no duration posted; no comment posted.

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“However formoterol administered intraperitoneally twice a day did not influence LPS-induced premature delivery (data not shown). Osmotic Pumps can maintain the blood concentration of formoterol for over 20h. Thus, it may be of importance that formoterol was continuously and uniformly administered.” (p. 201) Shinkai et al., Reproduction 2003;125:199-203.