ALZET® Osmotic Pump References: The Rate-Controlled Modulation of Hormone Levels

Q0759 Fukuda,S., Horimai,C., Harada,K., Wakamatsu,T., Fukasawa,H., Muto,S., Itai,A., Hayashi,M. Aldosterone-induced kidney injury is mediated by NFkappaB activation. Clinical and Experimental Nephrology 2011; 15(-1-):41-49. >>> Aldosterone, d-; Ethanol; water, dd-; SC; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; animal info (male, Wistar, 6-7 wks old); replacement therapy (nephrectomized); 3% ethanol used.

Q0864 Griol-Charhbili,V., Fassot,C., Messaoudi,S., Perret,C., Agrapart,V., Jaisser,F. Epidermal Growth Factor Receptor Mediates the Vascular Dysfunction But Not the Remodeling Induced by Aldosterone/Salt. Hypertension 2011; 57(-2-):238-U205. >>> Aldosterone; Ethanol; SC; Mice; 4 weeks; Controls received mp w/ vehicle; animal info (wa-2, wt, male); replacement therapy (nephrectomy); 10% ethanol used.

Q0892 Sakata,A., Mogi,M., Iwanami,J., Tsukuda,K., Min,L.J., Jing,F., Ohshima,K., Ito,M., Horiuchi,M. Female type 2 diabetes mellitus mice exhibit severe ischemic brain damage. Journal of the American Society of Hypertension 2011; 5(-1-):7-11. >>> Estradiol, beta; Propylene glycol; SC; Mice; 2 weeks; Controls received mp w/ vehicle; animal info (C57BL/6, 10 wks old, KKAy, male, female, OVX); replacement therapy (ovariectomized).

Q0641 Suresh,P.S., Jayachandra,K.C., Medhamurthy,R. The effect of progesterone replacement on gene expression in the corpus luteum during induced regression and late luteal phase in the bonnet monkey (Macaca radiata). Reproductive Biology and Endocrinology 2011; 9(-;-):U1-U16. >>> Progesterone; Ethanol; propylene glycol; Monkey; 2ML1; 24 hours; Animal info (adult, female, bonnet, macaca radiata, 3.3-5.1 kg); multiple pumps per animal (3); replacement therapy (corpus leuteum); endocrinology.

Q0842 Ackermann,D., Gresko,N., Carrel,M., Loffing-Cueni,D., Habermehl,D., Gomez-Sanchez,C., Rossier,B.C., Loffing,J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American Journal of Physiology-Renal Physiology 2010; 299(-6-):F1473-F1485. >>> Corticosterone; NaCl; SC; Rat; 2 days; Controls received mp w/ vehicle; animal info (male, Wistar); replacement therapy (adrenalecomy).

Q0034 Barazzoni,R., Zhu,X.X., DeBoer,M., Datta,R., Culler,M.D., Zanetti,M., Guarnieri,G., Marks,D.L. Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease. Kidney International 2010; 77(-1-):23-28. >>> Ghrelin, recomb human; Tween 80; saline; serum, rat; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; animal info (male, F344/NTacfBR); replacement therapy (Nephrectomy (5/6)).

Q0847 Barb,C.R., Hausman,G.J., Kraeling,R.R. Luteinizing hormone secretion as influenced by age and estradiol in the prepubertal gilt. ANIMAL REPRODUCTION SCIENCE 2010; 122(-3-4-):324-327. >>> Estradiol benzoate; Propylene glycol; SC; Pig; 2ML2; ; Controls received mp w/ vehicle; animal info (gilt, OVX, 90, 150, 210 day old); functionality of mp verified by serum estradiol levels; replacement therapy (ovariectomized).

Q0002 Batista,D.G., Neves,K.R., Graciolli,F.G., dos Reis,L.M., Graciolli,R.G., Dominguez,W.V., Neves,C.L., Magalhaes,A.O., Custodio,M.R., Moyses,R.M., Jorgetti,V. The Bone Histology Spectrum in Experimental Renal Failure: Adverse Effects of Phosphate and Parathyroid Hormone Disturbances. Calcified Tissue International 2010; 87(-1-):60-67. >>> Parathyroid hormone, recomb. rat (1-34); Cysteine; SC; Rat; 2ML4; 56 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 280-330 g); functionality of mp verified by hormone serum levels; replacement therapy (parathyroidectomy, nephrecotomy (5/6)); pumps replaced after 28 days; long-term study.

Q0003 Berbel,P., Navarro,D., Auso,E., Varea,E., Rodriguez,A.E., Ballesta,J.J., Salinas,M., Flores,E., Faura,C.C., De Escobar,G.M. Role of Late Maternal Thyroid Hormones in Cerebral Cortex Development: An Experimental Model for Human Prematurity. Cerebral Cortex 2010; 20(-6-):1462-1475. >>> Parathyroid hormone, rat (1-84); calcitonin, rat; thyroxine; Acetate buffer; SC; Rat (pregnant); 2001; 4-8 days; Teratology; peptides; animal info (Female, Wistar, 250-300 g); replacement therapy (parathyroidectomy).

P9910 Burek,M., rias-Loza,P.A., Roewer,N., Foerster,C.Y. Claudin-5 as a Novel Estrogen Target in Vascular Endothelium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010; 30(-2-):298-U317. >>> Estradiol; Cyclodextrin; SC; Mice; 1004; ; Controls received mp w/ vehicle; replacement therapy (ovariectomy); animal info (2 wks old, female, C57BL/6).

Q0109 Chambliss,K.L., Wu,Q.A., Oltmann,S., Konaniah,E.S., Umetani,M., Korach,K.S., Thomas,G.D., Mineo,C., Yuhanna,I.S., Kim,S.H., Madak-Erdogan,Z., Maggi,A., Dineen,S.P., Roland,C.L., Hui,D.Y., Brekken,R.A., Katzenellenbogen,J.A., Katzenellenbogen,B.S., Shaul,P.W. Non-nuclear estrogen receptor-alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. Journal of Clinical Investigation 2010; 120(-7-):2319-2330. >>> Estradiol; estrogen-dendrimer conjugate; IP; Mice (nude); 3, 7 weeks; 72 hours; Controls received mp w/ empty dendrimer; cardiovascular; cancer (breast); animal info (female, ERE-Luc reporter, 10-13 weeks old; Ex3aERKO, 8-9 weeks old; C57BL/6 Apoe-/-, 6 weeks old; SCID, 8 weeks old); functionality of mp verified by serum agent levels; replacement therapy (ovariectomy; pumps replaced after 28 days); long-term study; photon recording with light emission tomography (LET) system with a CCD camera; Research Diets D10001.

Q0120 Hewitt,S.C., Li,Y., Li,L.P., Korach,K.S. Estrogen-mediated Regulation of Igf1 Transcription and Uterine Growth Involves Direct Binding of Estrogen Receptor-alpha to Estrogen-responsive Elements. Journal of Biological Chemistry 2010; 285(-4-):2676-2685. >>> Insulin-like growth factor-1, synthetic long R3; Acetic acid; saline; IP; Mice; 18, 24 hours; Animal info (female, ERaKO KIKO, wt, 10 weeks old); peptides; replacement therapy (ovariectomy).

Q0018 Hunter,R.G., Bloss,E.B., McCarthy,K.J., McEwen,B.S. Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. Brain Research 2010; 1325(-;-):141-146. >>> Aldosterone; RU 28,362; SC; Rat; 7 days; Controls received mp w/vehicle; animal info (male, Sprague-Dawley, 70 days old); replacement therapy (adrenalectomy).

Q0102 Hutchens,M.P., Nakano,T., Kosaka,Y., Dunlap,J., Zhang,W.R., Herson,P.S., Murphy,S.J., Anderson,S., Hurn,P.D. Estrogen Is Renoprotective via a Nonreceptor-dependent Mechanism after Cardiac Arrest In Vivo. Anesthesiology 2010; 112(-2-):395-405. >>> ICI 182,780; estradiol, 17b-; DMSO; saline; SC; Mice; 1007D; ; Replacement therapy (ovariectomy); animal info (male, female, Er alpha beta ko, wt); 50% DMSO used; "Because we were unable to find precedent in the scientific literature for delivering ICI 182,780 via silastic implant, we used osmotic pumps." pg 397.

Q0125 Ji,H., Zheng,W., Wu,X., Liu,J., Ecelbarger,C.M., Watkins,R., Arnold,A.P., Sandberg,K. Sex Chromosome Effects Unmasked in Angiotensin II-Induced Hypertension. Hypertension 2010; 55(-5-):1275-1282. >>> Angiotensin II; Saline; SC; Mice; 1002; 2 weeks; Peptides; cardiovascular; animal info (male, female, MF1: wt, XY-/-, XXSry, XY-/-Sry, FCG, 6-9 months old); dose-response (fig 2 and 3); replacement therapy (gonadectomy);.

Q0126 Johnson,M.L., Ho,C.C., Day,A.E., Walker,Q.D., Francis,R., Kuhn,C.M. Oestrogen Receptors Enhance Dopamine Neurone Survival in Rat Midbrain. Journal of Neuroendocrinology 2010; 22(-4-):226-237. >>> Estradiol, 17b-; diarylpropionitrile; Saline, normal; DMSO; SC; Rat; 2004; 30 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 60 days old); replacement therapy (ovariectomy); 50% DMSO; neuroendocrinology.

P9884 Kamalov,G., Ahokas,R.A., Zhao,W.Y., Shahbaz,A.U., Bhattacharya,S.K., Sun,Y., Gerling,I.C., Weber,K.T. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-2-):H385-H394. >>> Aldosterone; SC; Rat; ; Replacement therapy (uniphrectomy), animal info (8 wks old, Sprague Dawley, uniphrectomy).

Q0022 Matsubara,B.B., Franco,M., Janicki,J.S., Matsubara,L.S. Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. Brazilian Journal of Medical and Biological Research 2010; 43(-5-):506-514. >>> Aldosterone; SC; Rat; 2002; 6 weeks; Control animals received no treatment; cardiovascular; animal info (male, Wistar, 300 g, 12 weeks old); replacement therapy (nephrectomy); pumps replaced; long-term study.

Q0079 Morte,B., Diez,D., Auso,E., Belinchon,M.M., Gil-Ibanez,P., Grijota-Martinez,C., Navarro,D., De Escobar,G.M., Berbel,P., Bernal,J. Thyroid Hormone Regulation of Gene Expression in the Developing Rat Fetal Cerebral Cortex: Prominent Role of the Ca2+/Calmodulin-Dependent Protein Kinase IV Pathway. Endocrinology 2010; 151(-2-):810-820. >>> Parathyroid hormone (1-84); calcitonin, rat; Acetate buffer; SC; Rat; 2001; ; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 250-300 g); replacement therapy (parathyroidectomy).

P9976 Nordquist,L., Shimada,K., Ishii,T., Furuya,D.T., Kamikawa,A., Kimura,K. Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase alpha-1-subunit in rats. DIABETES-METABOLISM RESEARCH AND REVIEWS 2010; 26(-3-):193-199. >>> C-peptide, human; insulin, recomb. human; SC; Rat; 2ML2; 1 weeks; Controls received mp w/ saline; animal info (male, Sprague Dawley, 15 wks old, 350-450 g.); replacement therapy (STZ-induced Diabetes).

Q0483 Osako,M.K., Nakagami,H., Koibuchi,N., Shimizu,H., Nakagami,F., Koriyama,H., Shimamura,M., Miyake,T., Rakugi,H., Morishita,R. Estrogen Inhibits Vascular Calcification via Vascular RANKL System Common Mechanism of Osteoporosis and Vascular Calcification. Circulation Research 2010; 107(-4-):466-U57. >>> Estradiol, 17b-; Propylene glycol; Mice; 1004; 3 months; Controls received mp w/saline; animal info (female, ApoE -/-, ovariectomy); long-term study; replacement therapy (ovariectomy).

Q0838 Park,D., Choi,D., Lee,J., Lim,D.S., Park,C. Male-like sexual behavior of female mouse lacking fucose mutarotase. BMC GENETICS 2010; 11(-;-):U1-U12. >>> Estradiol; Sesame oil; SC; Mice; 2004; 3 weeks; Animal info (FucM-/- (KO)); replacement therapy (ovariectomy).

Q0162 Sakata,A., Mogi,M., Iwanami,J., Tsukuda,K., Min,L.J., Jing,F., Iwai,M., Ito,M., Horiuchi,M. Female exhibited severe cognitive impairment in type 2 diabetes mellitus mice. LIFE SCIENCES 2010; 86(-17-18-):638-645. >>> Estradiol, beta-; Propylene glycol; IP; Mice; 1002; ; Replacement therapy (ovariectomy); animal info (8-12 wks old, C57BL/6, KKAY); diabetes.

Q0030 Searls,Y.M., Loganathan,R., Smirnova,I.V., Stehno-Bittel,L. Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia. Cardiovascular Diabetology 2010; 9(-;-):U1-U17. >>> Insulin; SC; Rat; 2004; 28 days; Controls received mp w/saline; peptides; animal info (male, DR-BB Wistar, 21-26 days old); comparison of SC injections vs. mp; replacement therapy (anti-RT6 mAB-induced diabetes); endocrinology; Humulin R, Humulin U and Humulin N used;.

P9502 Armaiz-Pena,G.N., Mangala,L.S., Spannuth,W.A., Lin,Y.G., Jennings,N.B., Nick,A.M., Langley,R.R., Schmandt,R., Lutgendorf,S.K., Cole,S.W., Sood,A.K. Estrous Cycle Modulates Ovarian Carcinoma Growth. Clinical Cancer Research 2009; 15(-9-):2971-2978. >>> Estradiol, 17b-; progesterone; megestrol acetate; Cyclodextrin, b-; water; SC; Mice (nude); ; Replacement therapy (ovariectomy); animal info (female, athymic); cancer (ovarian).

P9403 De Silva,D.S., Wilson,R.M., Hutchinson,C., Ip,P.C., Garcia,A.G., Lancel,S., Ito,M., Pimentel,D.R., Sam,F. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-6-):H1983-H1993. >>> Aldosterone, D-; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (nephrectomy); cardiovascular; animal info (male, FVB).

Q0552 Fan,Y.Y., Kohno,M., Nakano,D., Hitomi,H., Nagai,Y., Fujisawa,Y., Lu,X.M., Fu,H., Du,J., Ohmori,K., Hosomi,N., Kimura,S., Kiyomoto,H., Nishiyama,A. Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. Journal of Hypertension 2009; 27(-9-):1855-1862. >>> Aldosterone; Ethanol; SC; Rat; 2004; 6 weeks; Controls received mp w/ vehicle; animal info (Sprague-Dawley, 162-184 g); pumps replaced every 3 weeks; long-term study; replacement therapy (nephrectomy); 2% ethanol used.

P9871 Gillio-Meina,C., Phang,S.H., Mather,J.P., Knight,B.S., Kennedy,T.G. Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization. REPRODUCTION 2009; 137(-3-):537-552. >>> Carbaprostacyclin; cicaprost; AFP-07; L-165041; docasahexanoic acid; Ethanol; cyclodextrin, beta-; Tris; DMSO; indomethacin; Intrauterine (uterine horn); Rat; 2001; ; Controls received mp w/ vehicle; replacement therapy (ovariectomy); good methods (pg. 551); animal info (female, Sprague Dawley, 7 wks old, 200-225 g., OVX); 50% DMSO used; AFP-07 and cicaprost are high-affinity ligands for prostacyclin receptor; carbaprostacyclin is a ligand for both prostacyclin receptor and peroxisome proliferatoractivated receptor delta; tissue perfusion (uterus); 3 mg/ml beta-cyclodextrin used.

Q0455 Gotfredsen,K., Lindh,C.H., Berglundh,T. Does Longstanding Nicotine Exposure Impair Bone Healing and Osseointegration? An Experimental Study in Rabbits. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2009; 91B(-2-):918-923. >>> Nicotine tartrate; Water, sterile; SC; Rabbit; 6 months; Animal info (New Zealand, white, female); long-term study; pumps replaced monthly; multiple pumps per animal (2); "the results indicate the relative safety of nicotine replacement therapy for periods up to 6 months." pg 923.

P9662 Graciolli,F.G., Neves,K.R., dos Reis,L.M., Graciolli,R.G., Noronha,I.L., Moyses,R.M.A., Jorgetti,V. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia. NEPHROLOGY DIALYSIS TRANSPLANTATION 2009; 24(-5-):1416-1421. >>> Parathyroid hormone (1-34); Cysteine; SC; Rat; 2ML4; 56 days; Controls received mp w/vehicle; replacement therapy (parathyroidectomy); pumps replaced after 28 days; animal info (male, Wistar, 300-330g).

Q0118 Hammond,R., Mauk,R., Ninaci,D., Nelson,D., Gibbs,R.B. Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats. Hormones and Behavior 2009; 56(-3-):309-314. >>> Estradiol; diarylpropiolnitrile; G1; propylpyrazole triol; Cyclodextrin, hydroxypropyl beta-; DMSO; SC; Rat; 2006; ; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 3-4 months old, 300-350 g; replacement therapy (ovariectomy); 13.9% or 33.7% DMSO; GPR30 agonist (G-1); ERa agonist (PPT); ERb agonist (DPN); behavioral testing (DPM spatial learning and memory T-maze).

P9866 Haylor,J.L., Parker,E., Risbridger,G.P., Beale,D., Brown,B.L., Dobson,P.R.M., Clarke,I.J., Hart,J.E. Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide. REGULATORY PEPTIDES 2009; 152(-1-3-):48-53. >>> EPL001; antibody, EPL001, mouse, monoclonal; Kidney; Rat; 2002; ; Tissue perfusion (renal); replacement therapty (unilateral nephrectomy); peptides; animal info (male, Wistar, 250-300 g.); EPL001 is a novel sheep derived 14 amino acid peptide.

P9899 Higgins,E.W., Rao,A., Baumann,S.S., James,R.L., Kuehl,T.J., Muir,T.W., Pierce,L.M. Effect of estrogen replacement on the histologic response to polypropylene mesh implanted in the rabbit vagina model. American Journal of Obstetrics and Gynecology 2009; 201(-5-):U192-U200. >>> Estradiol, 17b-; PEG 300; SC; Rabbit; 2ML4; 12 weeks; Controls received mp w/vehicle; replacement therapy (ovariectomy); long-term study; pumps replaced at 4 week intervals; animal info (adult, New Zeland, White, female); "ALZET pumps...are precision drug administration tools that conveniently eliminate the need for daily injections and reduce animal handling," pg 505.e2.

P9630 Kramer,P.R., Bellinger,L.L. The Effects of Cycling Levels of 17-beta-Estradiol and Progesterone on the Magnitude of Temporomandibular Joint-Induced Nociception. Endocrinology 2009; 150(-8-):3680-3689. >>> Estradiol, 17-beta; PEG; Rat; ; Controls received mp w/vehicle; replacement therapy (ovariectomy); animal info (female, 250g, Sprague Dawley).

Q0536 Lin,J., Steenbergen,C., Murphy,E., Sun,J.H. Estrogen Receptor-beta Activation Results in S-Nitrosylation of Proteins Involved in Cardioprotection. Circulation 2009; 120(-3-):245-U157. >>> Estradiol; DPN; DMSO; saline; SC; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (C57BL/6J wt, ER-beta knockout, female, 8 wks old); replacement therapy (ovariectomy); 50% DMSO used; DPN (also known as 2,2-bis(4-hydroxyphenyl)-proprionitrile) is an ER-beta selective agonist.

P9428 Mancinelli,R., Onori,P., Gaudio,E., Demorrow,S., Franchitto,A., Francis,H., Glaser,S., Carpino,G., Venter,J., Alvaro,D., Kopriva,S., White,M., Kossie,A., Savage,J., Alpini,G. Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1. American Journal of Physiology-Gastrointestinal and Liver Physiology 2009; 297(-1-):G11-G26. >>> Follicle-stimulating hormone; antibody, polyclonal anti-FSH; serum, nonimmune; antide; Saline; IP; Rat; 1 week; Controls received mp w/ vehicle; replacement therapy (bile duct ligation); animal info (female, male, Fischer 344, 150-175 g.); antide is a gonadotropin-releasing hormone antagonist.

P9730 Mark,P.J., Augustus,S., Lewis,J.L., Hewitt,D.P., Waddell,B.J. Changes in the Placental Glucocorticoid Barrier During Rat Pregnancy: Impact on Placental Corticosterone Levels and Regulation by Progesterone. Biology of Reproduction 2009; 80(-6-):1209-1215. >>> Estradiol; Propylene glycol; SC; Rat (pregnant); ; Replacement therapy (ovariectomy); animal info (Nulliparous, albino, Wistar, 8-12 wks old).

Q0698 Meyer,R.D., Laz,E.V., Su,T., Waxman,D.J. Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5. MOLECULAR ENDOCRINOLOGY 2009; 23(-11-):1914-1926. >>> Growth hormone, recomb. rat, human; Rat; 7 days; Controls were untreated; animal info (male, Fischer 344, 9-13 wks old); replacement therapy (hypophysectomy).

P9963 Puri,J., Hutchins,B., Bellinger,L.L., Kramer,P.R. Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint. Reproductive Biology and Endocrinology 2009; 7(-;-):U1-U8. >>> Estradiol benzoate, 17b-; Polyethylene glycol; Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); animal info (Sprague Dawley, 230 g.); 14-day pump used.

Q0565 rias-Loza,P.A., Muehlfelder,M., Elmore,S.A., Maronpot,R., Hu,K., Blode,H., Hegele-Hartung,C., Fritzemeier,K.H., Ertl,G., Pelzer,T. Differential Effects of 17-beta-Estradiol and of Synthetic Progestins on Aldosterone-Salt-Induced Kidney Disease. Toxicologic Pathology 2009; 37(-7-):969-982. >>> Aldosterone; NaCl; Rat; ; Animal info (female, Wistar); replacement therapy (uniphrectomy).

P9440 Saito,T., Saito,T., Kasono,K., Otani,T., Tamemoto,H., Kawakami,M., Sasaki,S., Ishikawa,S. Vasopressin-dependent upregulation of aquaporin-2 gene expression in aged rats with glucocorticoid deficiency. ACTA PHYSIOLOGICA 2009; 196(-2-):239-247. >>> Aldosterone; dexamethasone; SC; Rat; 2ML4; 17 days; Controls received mp w/ both agents; replacement therapy (adrenalectomy); animal info (male, Sprague Dawley, 6 wks old, 200-250 g.; 52 wks old, 650-700 g.); nephrology.

Q0640 Singhal,R., Shankar,K., Badger,T.M., Ronis,M.J. Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17 beta-estradiol treatment. Journal of Endocrinology 2009; 202(-1-):141-152. >>> Estradiol; Polyethylene glycol; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (adult, female, Sprague-Dawley); replacement therapy (OVX, ovariectomy).

P9855 Singhal,R., Badger,T.M., Ronis,M.J. Estrogenic status modulates the effect of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA). TOXICOLOGY AND APPLIED PHARMACOLOGY 2009; 234(-1-):89-97. >>> Estradiol; Polyethylene glycol; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); animal info (adult, female, Sprague Dawley, PND30).

Q0671 Szentirmai,E., Kapas,L., Sun,Y.X., Smith,R.G., Krueger,J.M. The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-33-):14069-14074. >>> Obestatin; Saline, isotonic; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (preproghrelin KO); peptides; half-life (22 min) pg 14072; replacement therapy (obestatin); "Replacement of obestatin by bolus injection is problematic because of the short half-life (24) of the peptide (22 +/- 2 min), and disturbing the animals by the injection procedure interferes with the thermoregulatory response. Osmotic minipumps also have limitations because of the unknown stability of stored obestatin and unknown dose-response relationship." pg 14072.

Q0199 Tian,J., Shidyak,A., Periyasamy,S.M., Haller,S., Taleb,M., El-Okdi,N., Elkareh,J., Gupta,S., Gohara,S., Fedorova,O.V., Cooper,C.J., Xie,Z.J., Malhotra,D., Bagrov,A.Y., Shapiro,J.I. Spironolactone Attenuates Experimental Uremic Cardiomyopathy by Antagonizing Marinobufagenin. Hypertension 2009; 54(-6-):1313-1U76. >>> Spironolactone; marinobufagenin; SC; Rat; 2004; 4 weeks; Replacement therapy (nephrectomy); animal info (male, Sprague Dawley, 250-300 g.).

Q0952 Tofovic,S.P., Zhang,X.C., Jackson,E.K., Zhu,H., Petrusevska,G. 2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats. VASCULAR PHARMACOLOGY 2009; 51(-2-3-):190-197. >>> Estradiol, 2-methoxy; Rat; 2ML4; ; Animal info (female, Sprague-Dawley, 200-250 g, bilateral ovariectomy); half-life (p. 193) "between 30 min and 2 h"; replacement therapy (ovariectomy).

Q0624 Tsuneda,T., Yamashita,T., Kato,T., Sekiguchi,A., Sagara,K., Sawada,H., Aizawa,T., Fu,L.T., Fujiki,A., Inoue,H. Deficiency of Testosterone Associates with the Substrate of Atrial Fibrillation in the Rat Model. Journal of Cardiovascular Electrophysiology 2009; 20(-9-):1055-1060. >>> Testosterone propionate; SC; Rat; 3 weeks; Animal info (male, Sprague-Dawley, 6 mo old); replacement therapy (orchidectomy).

Q0518 Wang,X., Kruithof-de Julio,M., Economides,K.D., Walker,D., Yu,H.L., Halili,M.V., Hu,Y.P., Price,S.M., bate-Shen,C., Shen,M.M. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 2009; 461(-7263-):495-U61. >>> Testosterone; Ethanol; PEG 400; SC; Mice; 4 weeks; Animal info (adult, male, castrated, Nkx3-1CreERT2/+); replacement therapy (orchidectomy).

Q0210 Wilson,R.M., De Silva,D.S., Sato,K., Izumiya,Y., Sam,F. Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure. Hypertension 2009; 54(-3-):583-U265. >>> Aldosterone, d-; Mice; 4 weeks; Controls received mp w/ saline; replacement therapy (uniphrectomized); animal info (10 wks old, FVB, UNX, 25-27 g.).

Q0568 Xu,J., Kirigiti,M.A., Grove,K.L., Smith,M.S. Regulation of Food Intake and Gonadotropin-Releasing Hormone/Luteinizing Hormone during Lactation: Role of Insulin and Leptin. Endocrinology 2009; 150(-9-):4231-4240. >>> Insulin, human; leptin, rat; Saline; SC; Rat; 1003D; 48 hours; Controls received mp w/ vehicle; animal info (d 8-9 post partum, 6 d post ovariectomy); multiple pumps per animal (2); replacement therapy (ovariectomized).

P9467 Xue,B.J., Badaue-Passos,D.Jr, Guo,F., Gomez-Sanchez,C.E., Hay,M., Johnson,A.K. Sex differences and central protective effect of 17 beta-estradiol in the development of aldosterone/NaCl-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-5-):H1577-H1585. >>> Aldosterone; estradiol, 17b-; ICI 182,780; SC; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy, castration); cardiovascular; multiple pumps per animal (2); animal info (male, Sprague Dawley, 10-12 wks old); cannula placement verified histologically; estrogen receptor antagonist; endocrinology.

P9971 Xue,B.J., Singh,M., Guo,F., Hay,M., Johnson,A.K. Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-5-):H1638-H1646. >>> L-NAME; L-VNIO; Angiotensin II; SC; CSF/CNS; Mice; 1002; 7, 14 days; Controls received mp w/ vehicle; peptides; cardiovascular; enzyme ihibitor (NO synthase); animal info (male, female, C57BL/6, 12-16 weeks old); replacement therapy (ovariectomy, gonadectomy); cannula placement confirmed post mortem histologically; N5-(1-imino-3-butenyl)-L-ornithine (L-VNIO).

Q0667 Zhang,M.M., Chen,J., Liu,S.J., You,L., Lin,S.Y., Gu,Y. The Role of Na(+)-H(+) Exchanger Isoform 1 in Aldosterone-Induced Glomerulosclerosis in Vivo. RENAL FAILURE 2009; 31(-8-):726-735. >>> Aldosterone; Saline; SC; Rat; 2004; 12 weeks; Controls received mp w/ vehicle; animal info (5 wks old, male, Sprague-Dawley, 180-210 g, nephrectomized); pumps replaced every 4 weeks; replacement therapy (nephrectomy).

Q0823 Zhang,Q.G., Raz,L., Wang,R.M., Han,D., De Sevilla,L., Yang,F., Vadlamudi,R.K., Brann,D.W. Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor alpha-Mediated Inhibition of NADPH Oxidase Activation. Journal of Neuroscience 2009; 29(-44-):13823-13836. >>> Estradiol, 17-beta; SC; Rat; 7 days; Controls received placebo; animal info (adult, female, Sprague Dawley, 3 mo old); replacement therapy (ovariectomy); "(0.025 mg) of E2 used produces serum E2 levels of ~10 pg/ml, which represents physiological low diestrus I levels of E2" pg 13824.

P9130 Almon,R.R., Yang,E., Lai,W., Androulakis,I.P., Ghimbovschi,S., Hoffman,E.P., Jusko,W.J., DuBois,D.C. Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 295(-4-):R1031-R1047. >>> Methylprednisolone; Rat; 7 days; Replacement therapy (adrenalectomy); animal info (male, Wistar).

P9259 Almon,R.R., Yang,E., Lai,W., Androulakis,I.P., DuBois,D.C., Jusko,W.J. Circadian variations in rat liver gene expression: Relationships to drug actions. Journal of Pharmacology and Experimental Therapeutics 2008; 326(-3-):700-716. >>> Methylprednisolone; Rat; 1-7 days; Replacement therapy (adrenalectomy); comparison of bolus injection vs. mp; animal info (male, Wistar, 225-275 g.).

P9812 Bonacasa,B., Sanchez,M.L., Rodriguez,F., Lopez,B., Quesada,T., Fenoy,F.J., Hernandez,I. 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats. Maturitas 2008; 61(-4-):310-316. >>> Methoxyestradiol, 2-; SC; Rat; 2ML4; 8 weeks; Controls were left intact and untreated; pumps replaced after 4 weeks; animal info (male, female, SHR, 10 wks old, OVX); replacement therapy (ovariectomy).

P9021 Chun,T.Y., Chander,P.N., Kim,J.W., Pratt,J.H., Stier,CT Jr  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 295(-2-):E305-E312. >>> Angiotensin II; aldosterone; Ethanol; SC; Rat; 2 weeks; Controls received mp w/ vehicle; replacement therapy (adrenalectomy); animal info (male, SHRSP/A3N, 60 days old, adrenalectomy); peptides.

P8961 Danchuk,S., Sukhanov,S., Horvat,D., Uddin,M.N., Puschett,J.B. Effects of resibufogenin in experimental hypertension. American Journal of Nephrology 2008; 28(-1-):8-13. >>> Angiotensin II; SC; Rat; 2002; 13 days; Controls received sham surgery; functionality of mp verified by systolic blood pressure; replacement therapy (nephrectomy); peptides; animal info (male, CD, 300-350 g.); nephrology.

P8842 DeBoer,M.D., Zhu,X.X., Levasseur,P.R., Inui,A., Hu,Z.Y., Han,G.F., Mitch,W.E., Taylor,J.E., Halem,H.A., Dong,J.Z., Datta,R., Culler,M.D., Marks,D.L. Ghrelin treatment of chronic kidney disease: Improvements in lean body mass and cytokine profile. Endocrinology 2008; 149(-2-):827-835. >>> Ghrelin, human; BIM-28131; BIM-28125; Saline; serum, inactivated rate; Tween 80; SC; Rat; 2002; 14 days; Controls received mp w/ saline; replacement therapy (Nephrectomy 5/6); half-life (pg. 834) "short"; peptides; animal info (male, F344/NTacfBR, 130-150g.); endocrinology; synthetic receptor agonists; 5% Tween 80.

P8832 Dina,O.A., Khasar,S.G., essandri-Haber,N., Green,P.G., Messing,R.O., Levine,J.D. Alcohol-induced stress in painful alcoholic neuropathy. European Journal of Neuroscience 2008; 27(-1-):83-92. >>> Epinephrine; Saline; ascorbic acid; SC; Rat; 2004; 3 weeks; Replacement therapy (adrenal medullectomy); animal info (male, Sprague Dawley, 250-450g.).

P8771 Elmarakby,A.A., Quigley,J.E., Imig,J.D., Pollock,J.S., Pollock,D.M. TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-1-):R76-R83. >>> Etanercept; SC; Rat; 3 weeks; Replacement therapy (nephrectomy); animal info (male, Sprague Dawley, 200-250g.); TNF-alpha inhibitor.

R0253 Fusani,L. Endocrinology in field studies: Problems and solutions for the experimental design. General and Comparative Endocrinology 2008; 157(-3-):249-253. >>> Testosterone; SC; ; Replacement therapy (gonadectomy); comparison of silastic implants vs. time release pellets vs. mp; endocrinology; mp not used, just discussed as available option.

P9314 Goncalves,I., Alves,C.H., Quintela,T., Baltazar,G., Socorro,S., Saraiva,M.J., Abreu,R., Santos,C.R.A. Transthyretin is up-regulated by sex hormones in mice liver. MOLECULAR AND CELLULAR BIOCHEMISTRY 2008; 317(-1-2-):137-142. >>> Estradiol, 17b-; dihydrotestosterone, 5a-; Polypropylene glycol; ethanol; SC; Mice; 1007D; 1 week; Controls received mp w/ vehicle or sham operation; replacement therapy (ovariectomy, orchidectomy); animal info (male, female, 129S1/Sv, 5 months old): 0.5% EtOH.

R0254 Hasko,G., Pacher,P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. Journal of Leukocyte Biology 2008; 83(-3-):447-455. >>> ATL146c; Rat; mice; rabbit; ; Replacement therapy (STZ-induced diabetes); ischemia (renal, hepatic); review, see ref #'s 79, 90, 91, 92, 93, 95.

P9033 Karpac,J., Czyzewska,K., Kern,A., Brush,R.S., Anderson,R.E., Hochgeschwender,U. Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 295(-2-):E446-E455. >>> ACTH (1-24); PBS; BSA; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; replacement therapy (corticosterone); animal info (POMC wt, hetero, mut, male, female).

P9422 Kyuhou,S.I. Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats. Neuroscience Letters 2008; 448(-1-):10-14. >>> ICI 182,780; DMSO; CSF, artificial; CSF/CNS; Rat; 2001; 7 days; Controls received vehicle; replacement therapy (ovariectomy); ALZET brain infusion kit 2 used; animal info (female, Sprague Dawley, 180-250 g.); neurodegenerative (Parkinson's Disease); behavioral testing (rotation test, stepping test, cylinder test, motor dysfunction, forelimb akinesia); ICI 182780 is a estrogen receptor antagonist.

P9849 Lefter,R., Doan,V.D., Joseph,V. Contrasting effects of estradiol and progesterone on respiratory pattern and hypoxic ventilatory response in newborn male rats. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2008; 164(-3-):312-318. >>> Estradiol; progesterone; Propylene glycol; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (adult, female, male, multiparous, Sprague Dawley); estradiol and progesterone in same pump; replacement therapy (ovariectomy).

P9425 Leranth,C., Hajszan,T., Szigeti-Buck,K., Bober,J., MacLusky,N.J. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-37-):14187-14191. >>> Bisphenol A; Propylene glycol; SC; Monkey; 2ML4; 28 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; replacement therapy (ovariectomy); post op. care (buprenorphine, carprofen); animal info (female, African green, 4-5 kg.).

P8841 Mueller-Krebs,S., Kihm,L.P., Zeier,B., Gross,M.L., Deppisch,R., Wieslander,A., Henle,T., Penndorf,I., Oh,J., Reiser,J., Nawroth,P.P., Zeier,M., Schwenger,V. Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure. European Journal of Clinical Investigation 2008; 38(-5-):296-305. >>> Glucose degradation products; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/ saline; replacement therapy (5/6 nephrectomy); toxicology; animal info (male, Sprague Dawley, 230-270g.); nephrology.

P8854 Mueller,A.D., Pollock,M.S., Lieblich,S.E., Epp,J.R., Galea,L.A.M., Mistlberger,R.E. Sleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormones. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-5-):R1693-R1703. >>> Corticosterone; PEG 400; SC; Rat; 2ML2; 7, 11 days; Replacement therapy (adrenalectomy); dose-response (Fig. 6); comparison of oral vs. mp; pumps replaced after 1 week; animal info (male, Long-Evans, 300-400g.; male, Sprague Dawley, 250-300g.); "the method of Cort replacement is crucial for detecting an effect of RSD on cell proliferation." (p. R1700), mp was successful at this.

P8800 Park,S., Hong,S.M., Sung,S.R., Jung,H.K. Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling. Endocrinology 2008; 149(-2-):445-454. >>> Leptin, recomb. rat; resistin, recomb. murine; CSF, artificial; CSF/CNS; Rat; 4 weeks; Controls received mp w/ vehicle; replacement therapy (pancreatectomy, 90%); peptides; animal info (male, Sprague Dawley, 220g).

P9435 Pitzer,C., Krueger,C., Plaas,C., Kirsch,F., Dittgen,T., Mueller,R., Laage,R., Kastner,S., Suess,S., Spoelgen,R., Henriques,A., Ehrenreich,H., Schaebitz,W.R., Bach,A., Schneider,A. Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain 2008; 131(--):3335-3347. >>> Colony-stimulating factor, G; Sorbitol; sodium acetate buffer; tween 80; SC; Mice (transgenic); 2004; 4, 8 weeks; 4 days; Controls received mp w/ vehicle; functionality of mp verified by G-CSF serum concentration; replacement therapy (sciatic nerve axotomy); long-term study; pumps replaced after 4 weeks; half-life (p. 5) 4 hours in humans and rodents; brain tissue distribution; peptide; animal info (female, C57BL/6, wt, SOD1(G93A)Tg, 11 wks old); neurodegenerative (ALS); behavioral testing (rotarod test, motor performance); 0.004% Tween 80 used.

P8938 Quintela,T., Alves,C.H., Goncalves,I., Baltazara,G., Saraiva,M.J., Santos,C.R.A. 5alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway. Brain Research 2008; 1229(-;-):18-26. >>> Dihydrotestosterone, 5 alpha-; Ethanol; propylene glycol; SC; Rat; mice; 1007D; 1 week; Controls received mp w/ vehicle; replacement therapy (orchidectomy); animal info (129s1/sv, HM male); 0.5% ethanol used.

P9436 Reuter,S., Velic,A., Edemir,B., Schroeter,R., Pavenstaedt,H., Gabriels,G., Bleich,M., Schlatter,E. Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2008; 456(-6-):1075-1084. >>> NHE-3I4167; Water, sterile; SC; Rat; 2001; 5 days; Replacement therapy (nephrectomy); immunology; animal info (male, Lewis, Lewis Brown Norway, 240-290 g., kidney transplantation); nephrology; Nat/Ht Exchanger type 3 Inihibitor #4167).

P9376 Rodriguez,W.E., Sen,U., Tyagi,N., Kumar,M., Carneal,G., Aggrawal,D., Newsome,J., Tyagi,S.C. PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice. International Journal of Biological Sciences 2008; 4(-4-):236-244. >>> FITC-Insulin; IP; Mice; 2001D; 24 hours; Replacement therapy (Alloxan-induced diabetes); cardiovascular; animal info (male, C57BL/6J); endocrinology.

P8802 Selektor,Y., Ahokas,R.A., Bhattacharya,S.K., Sun,Y., Gerling,I.C., Weber,K.T. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. American Journal of the Medical Sciences 2008; 335(-2-):105-110. >>> Aldosterone; Rat; 4 weeks; Controls received no treatment; replacement therapy (uninephrectomy); cardiovascular; animal info (male, Sprague Dawley).

P8869 Sennello,J.A., Fayad,R., Pini,M., Gove,M.E., Ponemone,V., Cabay,R.J., Siegmund,B., Dinarello,C.A., Fantuzzi,G. Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-23-):8085-8090. >>> Leptin; SC; Mice; 1 month; Replacement therapy (leptin deficient); peptides; animal info (ob/ob, slim, female, 6-10 wks old); obesity.

P8838 Singhal,R., Shankar,K., Badger,T.M., Ronis,M.J. Estrogenic status modulates aryl hydrocarbon receptor - mediated hepatic gene expression and carcinogenicity. Carcinogenesis 2008; 29(-2-):227-236. >>> Estradiol; SC; Rat; 2002; 15 days; Controls received mp w/ PEG; functionality of mp verified by serum E2 levels; replacement therapy (ovariectomy); animal info (female, Sprague Dawley, 50 days old).

P8827 Sinkevicius,K.W., Burdette,J.E., Woloszyn,K., Hewitt,S.C., Hamilton,K., Sugg,S.L., Temple,K.A., Wondisford,F.E., Korach,K.S., Woodruff,T.K., Greene,G.L. An estrogen receptor-alpha; knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology 2008; 149(-6-):2970-2979. >>> Insulin-like growth factor I, R3-; Acetic acid; IP; Mice; 1003D; 16-24 hours; Controls received IP vehicle or E2 injections; replacement therapy (ovariectomy); peptides; animal info (female, C57/BL6 wt, ENERKI, 12 wks old); endocrinology.

P9611 Takimoto,C., Kumagai,H., Osaka,M., Sakata,K., Onami,T., Kamayachi,T., Iigaya,K., Hayashi,K., Saruta,T., Itoh,H. Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats. HYPERTENSION RESEARCH 2008; 31(-10-):1941-1951. >>> Insulin; SC; Rat; 2 weeks; Controls received mp w/ vehicle; animal info (male, 13 wks old, SHR); replacement therapy (STZ-induced Diabetes).

P8798 Trivedi,P., Yang,R.H., Barouch,L.A. Decreased p110-alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. CELL CYCLE 2008; 7(-5-):560-565. >>> Leptin, recomb. mouse; SC; Mice; 1002; 4 weeks; Replacement therapy (leptin-deficient mice); pumps replaced after 14 days; cardiovascular; peptides; animal info (ob/ob, db/db, wt, 2-3 months old, 12-13 months); obesity.

P9292 Vivero,R.J., Joseph,D.E., Angeli,S., He,J., Chen,S.B., Eshraghi,A.A., Balkany,T.J., Van de Water,T.R. Dexamethasone Base Conserves Hearing from Electrode Trauma-Induced Hearing Loss. Laryngoscope 2008; 118(-11-):2028-2035. >>> Dexamethasone base; Perilymph, artificial; Ear (scala tympani); Guinea-pig; 2001; 8 days; Controls received mp w/ vehicle; replacement therapy (cochleostomy); tissue perfusion (scala tympani); animal info (pigmented, 250-300 g.).

P9269 Wang,L., Kitano,H., Hurn,P.D., Murphy,S.J. Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain. Journal of Cerebral Blood Flow and Metabolism 2008; 28(-11-):1824-1834. >>> Pyrazole triol, propyl-; diarylpropionitrile; DMSO; saline; SC; Mice; 1002; 10 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); no stress (see pg. 1828-1829); ischemia (cerebral); animal info (female, C57BL/6, 9-20 wks old, 20-25g, MCAO); 50% DMSO used; estrogen receptor agonists.

P8758 Warne,J.P., Foster,M.T., Horneman,H.F., Pecoraro,N.C., de Jong,H.K., Ginsberg,A.B., Akana,S.F., Dallman,M.F. The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 294(-1-):E190-E200. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced Diabetes, gastroduodenal branch vagotomy).