ALZET® Osmotic Pump References: The Rate-Controlled Modulation of Hormone Levels

16298 Jeremie Boucher,, Samir Softic,, Abdelfattah El Ouaamari,, Megan T. Krumpoch,, Andre Kleinridders,, Rohit N. Kulkarni,, Brian T. O’Neill,, C. Ronald Kahn1  Diabetes 2016; 66(--):2201-2213. >>> Leptin; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (Fat-specific IR, IGF1R, and IR/IGF1R knockout mice; 3 month old); functionality of mp verified by blood glucose levels; dose-response (pg 2204-2206); behavioral testing (cold-resistance testing); replacement therapy (leptin); Lipoatrophic diabetes; Dose (10 ug/mouse/d);.

16281 Zhang, F., Yu, X., He, C., Ouyang, X., Wu, J., Li, J., Zhang, J., Duan, X., Wan, Y., Yue, J. Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart. Toxicol Appl Pharmacol 2015; 289(-3-):495-506. >>> Growth hormone, recombinant; SC; mice; 1007D; Controls received sham operation; animal info (C57/B6, male and female, 8-10 wks, 18-25 g); functionality of mp verified by cardiac mRNA levels; replacement therapy (growth hormone); Cardiac mRNA; Dose (0.4 ug/h);.

16226 Parsi, S., Smith, P. Y., Goupil, C., Dorval, V., Hebert, S. S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids 2015; 4(--):e256. >>> miR-16 mimic; Saline; CSF/CNS (ventricle); mice; 1007D; Controls received mp w/ vehicle; animal info (Wild-type mice (C57BL/6, female, 2 months old)); ALZET brain infusion kit 2 used; dose-response (pg. 2); neurodegenerative (Alzheimer’s); post op. care (Anafen); replacement therapy (miRNA replacement therapy); brain tissue distribution; delayed delivery (12 hours delivery/day); potent inhibitor of amyloid precursor protein (APP) and BACE1 expression, AǞpeptide production, and Tau phosphorylation in cells; Dose (4.2Ǩg/Ǩl); Brain coordinates; ventricle A/P =−0.22 M/L = 0.5 D/v = 3.5).

16211 Meschin, P., Demion, M., Cazorla, O., Finan, A., Thireau, J., Richard, S., Lacampagne, A. p11 modulates calcium handling through 5-HT(4)R pathway in rat ventricular cardiomyocytes. Cell Calcium 2015; 58(-6-):549-57. >>> Brain-derived neurotrophic factor; saline; SC; rat; 2ML2; Controls received mp w/ vehicle; animal info (200–224 g male Wistar rats); functionality of mp verified by ECG (electrocardiograms); post op. care (lidocaine, heating pad); replacement therapy (neurotrophin); Dose (180 ng/day));.

16198 Li, J. Y., D'Amelio, P., Robinson, J., Walker, L. D., Vaccaro, C., Luo, T., Tyagi, A. M., Yu, M., Reott, M., Sassi, F., Buondonno, I., Adams, J., Weitzmann, M. N., Isaia, G. C., Pacifici, R. IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice. Cell Metab 2015; 22(-5-):799-810. >>> Parathyroid hormone, human (1-34); SC; mice; 1002; Controls received mp w/ vehicle; animal info: 16-week-old female mice, C57BL/6 WT; functionality of mp verified by flow cytometry; dose-response (pg 808); replacement therapy (human parathyroid hormone); immunology; peptides; Dose: 80 mg/kg/day.

16052 Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L., Ottinger, M. A. A comparative evaluation of treatments with 17beta-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease. Horm Behav 2016; 83(--):39-44. >>> DHED; estradiol, 17B-; Propylene glycol; SC; Mice (transgenic); 2004; Controls received mp w/ vehicle; animal info (female, APPswe/PS1dE9, 6 months old); functionality of mp verified by plasma levels (see figure S1 - E2 only; no assay for DHED); pumps replaced every 4 weeks; neurodegenerative (Alzheimer’s); replacement therapy (estradiol infusion); DHED aka 10Ǟ,17Ǟ-dihydroxyestra-1,4-dien-3-one; Dose (2 ug/day); Industry authored (AgyPharma LLC);.

15833 María Valero-Muñoz, PhD; Shanpeng Li, BS; Richard M. Wilson, BS; Maarten Hulsmans, PhD;, Tamar Aprahamian, PhD; JoséJ. Fuster, PhD; Matthias Nahrendorf, MD, PhD;, Philipp E. Scherer, PhD; Flora Sam, MD  Circ Heart Fail 2016; 9(--):1-10. >>> Aldosterone, D-; Saline; SC; Mice; Controls received mp w/ saline; animal info (C57BL6, 8 weeks old, 20-25g, uninephrectomy); replacement therapy (uninephrectomy); cardiovascular; bp measured using tail cuff; Dose (0.3 ug/h);.

15797 E. Maggioli, S. McArthur, C. Mauro, J. Kieswich, D.H.M. Kusters, C.P.M. Reutelingsperger, M. Yaqoob, E. Solito  Brain Behav. Immun 2016; 51(--):212-222. >>> Estradiol; Cyclodextrin, B-; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (C57BL6 or AnxA1 -/-, 2 months old, OVX ); replacement therapy (estradiol infusion); immunology; dose: 100nM.

15779 Akihiko Kimura, Yuko Ishida, Mizuho Nosaka, Yumi Kuninaka, Mizuki Hama, Takashi Kawaguchi, Shoichi Sakamoto, Kohei Shinozaki, Yumi Iwahashi, Tatsunori Takayasu, Toshikazu Kondo  Toxicology 2016; 339(--):9-18. >>> Estrogen-17B; Ethanol; PBS; Mice; 1002; Controls received no mp; Controls received no mp; Controls received no mp; replacement therapy (estrogen infusion); Dose (0.2 mg/kg/day);.

15725 Jeffrey A. Blair,, Russell Palm,, Jaewon Chang,, Henry McGee,, Xiongwei Zhu,, Xinglong Wang,, Gemma Casadesus  Horm. Behav 2016; 78(--):60-66. >>> Estradiol, 17b; leuprolide acetate; Saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J, 9 months old, OVX); pumps replaced every month; behavioral testing (morris water maze); replacement therapy (estradiol infusion); Dose (E2 1.1 ng/day; leuprolide 3.6 ug/day);.

15070 Sawada, H., Naito, Y., Oboshi, M., Iwasaku, T., Okuhara, Y., Morisawa, D., Eguchi, A., Hirotani, S., Masuyama, T., Naito, Y. Iron restriction inhibits renal injury in aldosterone/salt-induced hypertensive mice. HYPERTENSION RESEARCH 2015; 38(--):317-322. >>> Aldosterone; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8 weeks old, 20-23g); replacement therapy (uninephrectomy); cardiovascular; bp measured using tail cuff;.

15044 Montoya, T.I., Maldonado, P.A., Acevedo, J.F., Word, R.A., Word, R.A. Effect of Vaginal or Systemic Estrogen on Dynamics of Collagen Assembly in the Rat Vaginal Wall. BIOLOGY OF REPRODUCTION 2015; 92(--):U115-U123. >>> Estradiol; SC; Rat; Animal info (female, Sprague Dawley, 12 weeks old); replacement therapy (estradiol infusion);.

15255 Mennenga, S.E., Gerson, J.E., Koebele, S.V., Kingston, M.L., Tsang, C.W.S., Engler-Chiurazzi, E.B., Baxter, L.C., Bimonte-Nelson, H.A., Bimonte-Nelson, H.A. Understanding the cognitive impact of the contraceptive estrogen Ethinyl Estradiol: Tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity. PSYCHONEUROENDOCRINOLOGY 2015; 54(--):1-13. >>> Estradiol, ethinyl; Propylene glycol; SC; Rat; 2006; Controls received mp w/ vehicle; animal info (female, Fischer-344, OVX, 3 months old); functionality of mp verified by serum levels; dose-response (pg8); behavioral testing (water radial-arm maze, morris water maze, visible platform task); replacement therapy (estradiol infusion); long-term study;.

15017 Ding, W., Xu, C.Y., Wang, B., Zhang, M.M., Zhang, M.M. Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. MEDICAL SCIENCE MONITOR 2015; 21(--):U1-U8. >>> Aldosterone; Ethanol; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 220-250g); 0.5% ethanol used; replacement therapy (uninephrectomy); cardiovascular; immunology;.

15250 Lam, V., Takechi, R., Pallabage-Gamarallage, M., Giles, C., Mamo, J.C.L., Mamo, J.C.L. The Vitamin D, Ionised Calcium and Parathyroid Hormone Axis of Cerebral Capillary Function: Therapeutic Considerations for Vascular-Based Neurodegenerative Disorders. PLoS One 2015; 10(--):U4547-U4566. >>> Parathyroid hormone (1-34); Saline, isosmotic; cysteine; SC; Rat; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 7 weeks old); functionality of mp verified by residual volume and serum levels; 2% cysteine used; replacement therapy (parathyroid replacement); used wound clips; used 2ML size pumps; pumps primed; long-term study;.

15940 Morris, D. J., Latif, S. A., Brem, A. S. An alternative explanation of hypertension associated with 17alpha-hydroxylase deficiency syndrome. Steroids 2014; 79(--):44-8. >>> corticosterone; progesterone, hydroxy-; Propylene glycol; sc; rat; Controls received mp w/ vehicle; animal info: adrenally intact rats; functionality of mp verified by measuring systolic blood pressure pg 46; replacement therapy (the agents infused); Dose: 5 ug/hr of both agents.

14922 Dong, G.J., Fan, H.Y., Yang, Y.H., Zhao, G.F., You, M., Wang, T.T., Hou, Y.Y., Hou, Y.Y. 17beta-Estradiol enhances the activation of IFN-alpha signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKepsilon. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015; 1852(--):1585-1598. >>> Estradiol, 17b-; Ethanol; propylene glycol; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (female, C57BL6, 4 weeks old, OVX); 0.5% ethanol used; 99.5% polypropylene glycol used; replacement therapy (estradiol infusion);.

14802 Reizel, Y., Spiro, A., Sabag, O., Skversky, Y., Hecht, M., Keshet, I., Berman, B.P., Cedar, H., Cedar, H. Gender-specific postnatal demethylation and establishment of epigenetic memory. GENES&DEVELOPMENT 2015; 29(--):923-933. >>> Testosterone; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6, 3 or 20 weeks old); pumps replaced every 28 days; replacement therapy (testosterone replacement); long-term study; pumps primed for 48 hours in 37C saline;.

14531 Zhang, J., Lazarenko, O.P., Blackburn, M.L., Badger, T.M., Ronis, M.J.J., Chen, J.R., Chen, J.R. Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways. FASEB Journal 2014; 28(--):3134-3145. >>> Estradiol, b-; PEG 400; SC; Rat (pregnant); 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, GD4); replacement therapy (ovarectomized);.

14501 Yang, Y., Cuevas, S., Yang, S.F., Villar, V., Escano, C., Asico, L., Yu, P.Y., Jiang, X.L., Weinman, E.J., Armando, I., Jose, P.A., Yang, Y. Sestrin2 Decreases Renal Oxidative Stress, Lowers Blood Pressure, and Mediates Dopamine D(2) Receptor-Induced Inhibition of Reactive Oxygen Species Production. Hypertension 2014; 64(--):825-+. >>> RNA, small interfering sestrin2; Kidney (renal subcapsule); Mice; 1007D; Controls received mp w/ control RNA; animal info (C57BL6J); good methods (supplement, pg 2); post op. care (buprenorphine); replacement therapy (uninephrectomy); used ALZET PE tubing; bp measured using catheter;.

14493 Xue, B.J., Zhang, Z.M., Beltz, T.G., Guo, F., Hay, M., Johnson, A.K., Xue, B.J. Estrogen regulation of the brain renin-angiotensin system in protection against angiotensin II-induced sensitization of hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2014; 307(--):H191-H198. >>> Angiotensin II; estradiol, 17b-; angiotensin (1-7); A-779; Saline; DMSO; SC; CSF/CNS; Rat; 2001; 2002; Animal info (Sprague Dawley, 10-12 weeks old); ALZET brain infusion kit used; Multiple pumps per animal (2); replacement therapy (ovarectomized, estradiol infusion); cardiovascular; antihypertensive; peptides; bp measured using radiotelemetry (DSI);.

14460 Wang, B., Ding, W., Zhang, M.M., Li, H.M., Gu, Y., Gu, Y. Rapamycin Attenuates Aldosterone-Induced Tubulointerstitial Inflammation and Fibrosis. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015; 35(--):116-125. >>> Aldosterone; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (Sprague Dawley); replacement therapy (uninephrectomized); cardiovascular;.

14459 Wan, L., Tan, H.L., Thomas-Ahner, J.M., Pearl, D.K., Erdman, JW Jr, Moran, N.E., Clinton, S.K., Clinton, S.K. Dietary Tomato and Lycopene Impact Androgen Signaling- and Carcinogenesis-Related Gene Expression during Early TRAMP Prostate Carcinogenesis. Cancer Prevention Research 2014; 7(--):1228-1239. >>> Testosterone propionate; Cyclodextrin, sterile; Mice; Animal info (male, TRAMP +/- C57BL/6xFVB/N hybrid, 9 weeks old); cancer (prostate); replacement therapy (gonadectomy; testosterone replacement);.

14458 Walser, M., Schioeler, L., Oscarsson, J., Aaberg, M.A.I., Svensson, J., Aaberg, N.D., Isgaard, J., Aaberg, N.D. Different modes of GH administration influence gene expression in the male rat brain. Journal of Endocrinology 2014; 222(--):181-190. >>> Growth hormone, recombinant bovine; PBS; glycerol; sodium azide; SC; Rat; 2004; Animal info (male, Sprague Dawley, hypophysectomized); 0.02% sodium azide used; 1.6% glycerol used; comparison of injection vs mp; replacement therapy (hypophysectomy);.

14439 Terzian, A.L.B., Micale, V., Wotjak, C.T., Wotjak, C.T. Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice. European Journal of Neuroscience 2014; 40(--):2293-2298. >>> Estradiol, b-; Ethanol; propylene glycol; Mice; 1002; Animal info (male, CB1 KO, 8-12 weeks old, OVX); 0.5% ethanol used; behavioral testing (social interaction test; three-chamber social investigation test); replacement therapy (ovariectomized, estradiol infusion);.

14397 Shah, A., Frazer, A., Shah, A. Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats. Psychopharmacology 2014; 231(--):3685-3694. >>> Desipramine hydrochloride; Water, distilled; IP; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250-350g, ovariectomized); functionality of mp verified by serum levels; comparison of injection vs mp; dose-response (pg 3690); post op. care (penicillin and saline injection; atipamezol 1 mg/kg); behavioral testing (forced swimming test; locomotor activity); replacement therapy (estradiol pellets); solutions filtered through 0.9 um nitrocellulose filters; pumps primed at room temperature saline; used sutures;.

14392 Scott, E.L., Zhang, Q.G., Dong, Y., Han, D., Wang, R.M., Vadlamudi, R.K., Brann, D.W., Brann, D.W. Surgical menopause enhances hippocampal amyloidogenesis following global cerebral ischemia. JOURNAL OF SPORT AND HEALTH SCIENCE 2014; 3(--):206-216. >>> Estradiol, 17B-; Cyclodextrin, B-; SC; Rat; 2002; Controls received mp w/ vehicle; animal info (female, ovariectomized); 20% cyclodextrin used; ischemia (cerebral); replacement therapy (estradiol infusion); cardiovascular;.

14385 Sarvari, M., Deli, L., Kocsis, P., Mark, L., Maasz, G., Hrabouszky, E., Kallo, I., Gajari, D., Vastagh, C., Suemeg, B., Tihanyi, K., Liposits, Z., Sarvari, M. Estradiol and isotype-selective estrogen receptor agonists modulate the mesocortical dopaminergic system in gonadectomized female rats. Brain Research 2014; 1583(--):1-11. >>> Estradiol; Rat; 2004; Animal info (female, Harlan-Wistar 2 months old, ovariectomized); replacement therapy (estradiol infusion); mentions use of"silicone capsules", but only mentions pumps once;.

14317 Navarro, D., Alvarado, M., Morte, B., Berbel, D., Sesma, J., Pacheco, P., De Escobar, G.M., Bernal, J., Berbel, P., Berbel, P. Late Maternal Hypothyroidism Alters the Expression of Camk4 in Neocortical Subplate Neurons: A Comparison with Nurr1 Labeling. Cerebral Cortex 2014; 24(--):2694-2706. >>> Parathormone (1-84), rat; calcitonin, rat; Acetate buffer; SC; Rat; 2001; Animal info (female, Wistar, E0); replacement therapy (thyroidectomy); teratology;.

14297 Matsui, H., Masaki, T., Akinaga, Y., Kiba, A., Takatsu, Y., Nakata, D., Tanaka, A., Ban, J.K., Matsumoto, S., Kumano, S., Suzuki, A., Ikeda, Y., Yamaguchi, M., Watanabe, T., Ohtaki, T., Kusaka, M., Matsui, H. Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide. European Journal of Pharmacology 2014; 735(--):77-85. >>> TAK-448; TAK-683; leuprolide; DMSO; water, distilled; SC; Rat; 2001; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 9 weeks old, 318-368g, ORX); functionality of mp verified by plasma concentration; 50% DMSO used; cancer (prostate); dose-response (pg 80); replacement therapy (bilateral orchiectomy);.

14674 Bozic, M., Panizo, S., Sevilla, M.A., Riera, M., Soler, M.J., Pascual, J., Lopez, I., Freixenet, M., Fernandez, E., Valdivielso, J.M., Valdivielso, J.M. High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin. Journal of Hypertension 2014; 32(--):1822-1832. >>> Parathyroid hormone (1-34), recombinant rat; SC; Rat; 2002; Animal info (Sprague Dawley, 200-225g); functionality of mp verified by calcium serum levels; replacement therapy (parathyroidectomy); cardiovascular;.

13953 Xue, B.J., Zhang, Z.M., Johnson, R.F., Guo, F., Hay, M., Johnson, A.K. Central endogenous angiotensin-(1-7) protects against aldosterone/NaCl-induced hypertension in female rats. American Journal of Physiology-Heart and Circulatory Physiology 2013; 305(-5-):H699-H705. >>> Angiotensin (1-7), D-alanine; A-779; CSF/CNS; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 10-12 weeks old, OVX); ALZET brain infusion kit used; replacement therapy (ovariectomy); cardiovascular; peptides; antihypertensive; A-779 is an angiotensin (1-7) receptor antagonist; bp measured using radiotelemetry;.

13921 Sarvari, M., Kallo, I., Hrabovszky, E., Solymosi, N., Liposits, Z. Ovariectomy and Subsequent Treatment with Estrogen Receptor Agonists Tune the Innate Immune System of the Hippocampus in Middle-Aged Female Rats. PLoS One 2014; 9(-2-):U411-U422. >>> Estradiol, 17b-; agonist, estrogen receptor 16-alpha-lactone; Propylene glycol; SC; Rat; 2004; Controls received mp w/ vehicle or sham operation; animal info (female, Harlan-Wistar, OVX, 13 months old); replacement therapy (ovariectomized; estradiol infusion); immunology; 16-alpha-lactone estrogen agonist aka L2;.

13894 Panigrahy, D., Kalish, B.T., Huang, S., Bielenberg, D.R., Le, H.D., Yang, J., Edin, M.L., Lee, C.R., Benny, O., Mudge, D.K., Butterfield, C.E., Mammoto, A., Mammoto, T., Inceoglu, B., Jenkins, R.L., Simpson, M.A., Akino, T., Lih, F.B., Tomer, K.B., Ingber, D.E., Hammock, B.D., Falck, J.R., Manthati, V.L., Kaipainen, A., D'Amore, P.A., Puder, M., Zeldin, D.C., Kieran, M.W. Epoxyeicosanoids promote organ and tissue regeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2013; 110(-33-):13528-13533. >>> Epoxyeicosatrienoic acid, 14,15-; epoxyeicosatrienoic acid, 11,12-; IP; Mice; Controls received mp w/ vehicle; animal info (male, Tie2-CYP2C8-Tr, Tie2-CYP2J2-Tr, sEH-null, 6 months old); replacement therapy (partial hepatectomy); tissue and organ regeneration.

13881 Pichaiwong, W., Hudkins, K.L., Wietecha, T., Nguyen, T.Q., Tachaudomdach, C., Li, W., Askari, B., Kobayashi, T., O'Brien, K.D., Pippin, J.W., Shankland, S.J., Alpers, C.E. Reversibility of Structural and Functional Damage in a Model of Advanced Diabetic Nephropathy. Journal of the American Society of Nephrology 2013; 24(-7-):1088-1102. >>> Leptin; Saline; SC; Mice; 2004; 2006; Controls received mp w/ vehicle; animal info (BTBR ob/ob, 18 weeks old); functionality of mp verified by leptin serum levels; replacement therapy (leptin replacement); diabetes; bp measured using tail cuff; long-term study;.

13873 Mueller, A.D., Parfyonov, M., Pavlovski, I., Marchant, E.G., Mistlberger, R.E. The inhibitory effect of sleep deprivation on cell proliferation in the hippocampus of adult mice is eliminated by corticosterone clamp combined with interleukin-1 receptor 1 knockout. BRAIN BEHAVIOR AND IMMUNITY 2014; 35(-;-):182-188. >>> Corticosterone; PEG 400; ethanol; SC; Mice; 1002; Animal info (male, homozygous IL1RI null, 7-8 weeks old); 5% ethanol used; post op. care (buprenorphine 0.1 mg/kg, metacam 1 mg/kg SQ, ADX rats given saline in water bottles); replacement therapy (adrenalectomy); immunology; sleep deprivation study;.

13820 Ji, H., Rabbi, M.F., Labis, B., Pavlov, V.A., Tracey, K.J., Ghia, J.E. Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis. Mucosal Immunology 2014; 7(-2-):335-347. >>> McN-A-343; MTT; Saline; Mice; Controls received mp w/ vehicle; animal info (male, C57BL6, 7-9 weeks old); replacement therapy (vagotomy; splenic neuroectomy; splenectomy); immunology; McN-A-343 is an M1 mAChR antagonist; MTT is an M2 mAChR antatonist;.

13801 Hatano, R., Mukouchi, H., Matsumoto, Y., Kawaguchi, K., Kazama, I., Endo, Y., Toyama, H., Ejima, Y., Kurosawa, S., Kanai, Y., Matsubara, M., Asano, S., Hatano, R. Glucocorticoid mediates the transcription of OAT-PG, a kidney-specific prostaglandin transporter. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2014; 466(--):925-935. >>> Dexamethasone; SC; Rat; 2002; Controls received mp w/ saline; animal info (Sprague Dawley Rats, 180-250g); replacement therapy (adrenalectomy);.

13798 Han, S.I., Komatsu, Y., Murayama, A., Steffensen, K.R., Nakagawa, Y., Nakajima, Y., Suzuki, M., Oie, S., Parini, P., Vedin, L.L., Kishimoto, H., Shimano, H., Gustafsson, J.A., Yanagisawa, J., Yanagisawa, J. Estrogen Receptor Ligands Ameliorate Fatty Liver Through a Nonclassical Estrogen Receptor/Liver X Receptor Pathway in Mice. Hepatology 2014; 59(--):1791-1802. >>> Estradiol, 17B-; phloretin; Mice (transgenic); 2004; Animal info (female, C57BL6 or ERa flox/flox, 5 weeks old); replacement therapy (ovariectomized); phloretin is a phytoestrogen;.

13765 Fang, J., Sukumaran, S., DuBois, D.C., Almon, R.R., Jusko, W.J. Meta-Modeling of Methylprednisolone Effects on Glucose Regulation in Rats. PLoS One 2013; 8(-12-):U923-U940. >>> Methylprednisolone; Rat; 2ML4; 2001; Controls received mp w/ vehicle; animal info (Wistar); functionality of mp verified by plasma levels; dose-response (pg. 11, figure 5); replacement therapy (adrenalectomy); diabetes;.

13759 Doi, T., Doi, S., Nakashima, A., Ueno, T., Yokoyama, Y., Kohno, N., Masaki, T., Masaki, T. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats. PLoS One 2014; 9(--):U875-U881. >>> Aldosterone; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 220-250g, 6 weeks old); functionality of mp verified by increased bp; replacement therapy (uninephrectomy); immunology; bp measured using tail cuff; long-term study;.

13701 Akita, K., Harada, K., Ichihara, J., Takata, N., Takahashi, Y., Saito, K. A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate. European Journal of Pharmacology 2013; 720(-1-3-):107-114. >>> Dihydrotestosterone; methyltestosterone; NEP28; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 13 weeks old); dose-response (pg.110-112); neurodegenerative (Alzheimer's disease); replacement therapy (orchidectomized; androgen therapy); dihydrotestosterone aka DHT; methyltestosterone aka MT; NEP28 is a selective androgen receptor modulator (SARM); notes the use of a 21 day pump;.

13652 Nelson, B.S., Springer, R.C., Daniel, J.M. Antagonism of brain insulin-like growth factor-1 receptors blocks estradiol effects on memory and levels of hippocampal synaptic proteins in ovariectomized rats. Psychopharmacology 2014; 231(-5-):899-907. >>> JB1; Cerebrospinal fluid, artificial; CSF/CNS; Rat; 2006; Controls received mp w/ vehicle; animal info (female, Long Evans, 2 months old); ALZET brain infusion kit used; stress/adverse reaction: (see pg. 901); behavioral testing (radial maze); replacement therapy (ovarectomized); peptides; Cannula placement verified via Cresyl violet staining; cannula anchored to skull with screws and dental acrylic; JB1 is a IGF-1 receptor antagonist.

13606 Madularu, D., Shams, W.M., Brake, W.G. Estrogen potentiates the behavioral and nucleus accumbens dopamine response to continuous haloperidol treatment in female rats. European Journal of Neuroscience 2014; 39(-2-):257-265. >>> Haloperidol; Saline; SC; Rat; 2002; Animal info (female, Sprague Dawley, ovariectomized); behavioral testing (motor activity); replacement therapy (ovariectomized); pump removed after 12 days;.

13528 Zhang, Q.G., Wang, R.M., Scott, E., Han, D., Dong, Y., Tu, J.Y., Yang, F., Sareddy, G.R., Vadlamudi, R.K., Brann, D.W. Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain 2013; 136(-;-):1432-1445. >>> Estradiol, 17b-; SC; Rat; Controls received mp w/ placebo; animal info (female, 3 months old, Sprague Dawley, ovariectomized); neurodegenerative (Alzheimer's disease); behavioral testing (Morris Water Maze); replacement therapy (17beta estradiol after ovariectomy);.

13527 Weigt, C., Hertrampf, T., Kluxen, F.M., Flenker, U., Huelsemann, F., Fritzemeier, K.H., Diel, P. Molecular effects of ER alpha- and beta-selective agonists on regulation of energy homeostasis in obese female Wistar rats. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2013; 377(-1-2-):147-158. >>> Estradiol; agonist, estradiol receptor alpha-selective 16-alpha-VE2; agonist, estradiol receptor beta-selective 8-beta-VE2; DMSO; water; SC; Rat; Controls received sham surgery; animal info (Female, Wistar, 120-150g, 6 weeks old); replacement therapy (ovariectomy, estradiol infusion); long-term study; immunology;.

13514 Hattori, T., Murase, T., Sugiura, Y., Nagasawa, K., Takahashi, K., Ohtake, M., Ohtake, M., Miyachi, M., Murohara, T., Nagata, K. Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury. HYPERTENSION RESEARCH 2014; 37(-2-):125-133. >>> Aldosterone, d-; Saline; ethanol; SC; Rat; 2004; Animal info (Sprague Dawley, uninephrectomized, 6 wks old, male, inbred); replacement therapy (uninephrectomy); 0.5% ethanol used.

13459 Salyer, S.A., Parks, J., Barati, M.T., Lederer, E.D., Clark, B.J., Klein, J.D., Khundmiri, S.J. Aldosterone regulates Na+, K+ ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2013; 1833(-10-):2143-2152. >>> Aldosterone; Rat; Controls received mp with vehicle or sham operated; animal info (male, Sprague Dawley, 100-150g); replacement therapy (adrenalectomy); immunology;.

13102 Balgobin, S., Montoya, T.I., Shi, H.L., Acevedo, J.F., Keller, P.W., Riegel, M., Wai, C.Y., Word, R.A. Estrogen Alters Remodeling of the Vaginal Wall after Surgical Injury in Guinea Pigs. Biology of Reproduction 2013; 89(-6-):U91-U100. >>> Estradiol; Polyethylene glycol; SC; Guinea pig; 2006; Control animals received mp w/ vehicle; animal info (virginal, female, adult, Hartley, 12 wks old); replacement therapy (bilateral oophrectomy).

13101 Chen, J.R., Wang, T.J., Lim, S.H., Wang, Y.J., Tseng, G.F. Testosterone modulation of dendritic spines of somatosensory cortical pyramidal neurons. Brain Structure&Function 2013; 218(-6-):1407-1417. >>> Testosterone; flutamide; anastrozole; DMSO;ethanol; SC; Rat; 2ML2; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, adult, 350-400 g); pumps replaced after 2 weeks; replacement therapy (castrated).

13033 Basha, M.E., Chang, S., Burrows, L.J., Lassmann, J., Wein, A.J., Moreland, R.S., Chacko, S. Effect of Estrogen on Molecular and Functional Characteristics of the Rodent Vaginal Muscularis. Journal of Sexual Medicine 2013; 10(-5-):1219-1230. >>> Estradiol, 17-; Cyclodextrin; SC; Rat; 2002; Control animals received mp w/ saline; animal info (Sprague Dawley, female, 3-4 mo old, 250-300 g); replacement therapy (ovariectomy).

12908 Bartell, S.M., Han, L., Kim, H.N., Kim, S.H., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Chambliss, K.L., Shaul, P.W., Roberson, P.K., Weinstein, R.S., Jilka, R.L., Almeida, M., Manolagas, S.C. Non-Nuclear-Initiated Actions of the Estrogen Receptor Protect Cortical Bone Mass. MOLECULAR ENDOCRINOLOGY 2013; 27(-4-):649-656. >>> Estradiol; dendrimer, empty estradiol; IP; Mice; 2006; Control animals received mp w/ vehicle; animal info (C57BL/6, female, 15 wks old); replacement therapy (ovariectomy); long-term study;.

12892 Babbs, R.K., Unger, E.L., Corwin, R.L.W. 2-Hydroxyestradiol enhances binge onset in female rats and reduces prefrontal cortical dopamine in male rats. Hormones and Behavior 2013; 63(-1-):88-96. >>> Estradiol, hydroxy 2-; PEG 400; SC; Rat; 2ML4; Control animals received mp w/ vehicle; animal info (Sprague Dawley, female); replacement therapy (ovariectomy); wound clips used; half-life (pg.89)..

 

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What researchers are saying...

“We developed the optic nerve/osmotic pump infusion technique to deliver soluble ligands, agonists, or antagonists directly into the optic nerve.The advantages of this technique are that the infused drugs remain largely confined within the experimental nerve, reducing the impact of potential systemic side effects; mere placement of the catheter and subsequent infusion of the vehicle solution do not promote lesion-like changes within the optic nerve…” Rodgers et al., GLIA 41:180-190; 2003.