References on the Administration of Antihypertensives Using ALZET® Osmotic Pumps

1. Atenolol

15016 Disdier, C., Devoy, J., Cosnefroy, A., Chalansonnet, M., Herlin-Boime, N., Brun, E., Lund, A., Mabondzo, A., Mabondzo, A. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat. Particle and Fibre Toxicology 2015; 12(--):U1-U20. >>> Atenolol; digoxin; prazosin; PEG 200; DMSO; SC; Rat; 2001D; Animal info (male, Fisher F344, 8 weeks old, 180-250g); 50% PEG 200 used; 50% DMSO used;.

14312 Nagai, H., Kuwahira, I., Schwenke, D.O., Tsuchimochi, H., Nara, A., Inagaki, T., Ogura, S., Fujii, Y., Umetani, K., Shimosawa, T., Yoshida, K.I., Pearson, J.T., Uemura, K., Shirai, M., Nagai, H. beta(2)-Adrenergic Receptor-Dependent Attenuation of Hypoxic Pulmonary Vasoconstriction Prevents Progression of Pulmonary Arterial Hypertension in Intermittent Hypoxic Rats. PLoS One 2014; 9(--):U369-U377. >>> Atenolol; nadolol; SC; Rat; 2006; Animal info (male, Sprague Dawley, 7 weeks old); cardiovascular; antihypertensive; long-term study;.

13409 Ling, S.K., Nanhwan, M., Qian, J.Q., Kodakandla, M., Castillo, A.C., Thomas, B., Liu, H.J., Ye, Y.M. Modulation of microRNAs in hypertension-induced arterial remodeling through the beta1 and beta3-adrenoreceptor pathways. Journal of Molecular and Cellular Cardiology 2013; 65(-;-):127-136. >>> Nebivolol; atenolol; Rat; Controls received mp w/ vehicle; animal info (Dahl salt sensitive, 6 weeks old); long-term study; cardiovascular; antihypertensive;.

13160 Lin, Q., Wang, F.F., Yang, R., Zheng, X.M., Gao, H.B., Zhang, P. Effect of Chronic Restraint Stress on Human Colorectal Carcinoma Growth in Mice. PLoS One 2013; 8(-4-):U1127-U1137. >>> Epinephrine; atenolol; ICI 118,551; PBS; ascorbic acid; SC; Mice (nude); 1002; Controls received mp w/ PBS, PHE (2mg/kg/d) and PRO (2mg/kg/d), CRS PBS, CRS PHE (2mg/kg/d) and PRO (2mg/kg/d); animal info (nude); cancer (colorectal); dose-response (Fig.4, S5); ICI 118,551 is a specific B2-AR antagonist;"Considering the critical role of stress in regulating tumor growth and the fact that stress hormones and their antagonists could be quickly metabolized, we used microosmotic pumps instead of repeated injection to administer the stress hormones and antagonists to reduce the stress response as much as possible during manipulations of the animals."pg 9.

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2. Benazepril

9732 Abu-Taha, M., Rius, C., Hermenegildo, C., Noguera, I., Cerda-Nicolas, J.M., Issekutz, A.C., Jose, P.J., Cortijo, J., Morcillo, E.J., Sanz, M.J. Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Prevented by Chronic Treatment with Low Doses of Estrogen or Losartan. Journal of Immunology 2009; 183(-2-):1393-1402. >>> Estradiol, 17b-; benazepril; DMSO; SC; Rat; 2004; Controls received mp w/ vehicle or sham operation; animal info (male, female, Sprague Dawley, OVX); 50% DMSO used; dose (5 ug/kg/d).

6754 Mizukami, M., Hasegawa, H., Kohro, T., Toko, H., Kudoh, T., Zou, Y.Z., Aburatani, H., Komuro, I. Gene expression profile revealed different effects of angiotensin II receptor blockade and angiotensin-converting enzyme inhibitor on heart failure. Journal of Cardiovascular Pharmacology 2003; 42(--):S1-S6. >>> Benazepril; candesartan; SC; Rat; 2ML4; Blood pressure taken.

6535 Yagi, S., Morita, T., Katayama, S. Combined treatment with an AT1 receptor blocker and angiotensin converting enzyme inhibitor has an additive effect on inhibiting neointima formation via improvement of nitric oxide production and suppression of oxidative stress. HYPERTENSION RESEARCH 2004; 27(-2-):129-135. >>> Valsartan; benazepril; Potassium hydroxide; HCL; SC; Rat; Controls received mp w/ vehicle; dose-response (p131); pump model not stated.

3297 Chow, L., de Gasparo, M., Levens, N. Improved glucose metabolism following blockade of angiotensin converting enzyme but not angiotensin AT receptors. Eur. J. Pharmacol 1995; 282(--):77-86. >>> Benazepril; Valsartan; Water, distilled; NaOH; HCI; IP; rat; 2ML4; controls received mp with saline; long-term study, pumps replaced every 28 days; valsartan is an angiotensin AT1 receptor antagonist; antihypertensive.

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3. Benazeprilat

13221 Thomas, C.M., Yong, Q.C., Seqqat, R., Chandel, N., Feldman, D.L., Baker, K.M., Kumar, R. Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clinical Science 2013; 124(-7-8-):529-541. >>> Insulin; aliskiren (renin inhibitor); benazeprilat (ACEi); valsartan (ARB); streptozotocin; Saline; SC; Mice; 1004; Controls received mp w/vehicle, or (0.1M sodium citrate buffer (pH 4.5)); cardiovascular; animal info (male, C57b16/J, 12 weeks, blood glucose>250 mg/dl); pumps replaced every 4 weeks; enzyme inhibitor (renin); long-term study; diabetes;.

13169 Yong, Q.C., Thomas, C.M., Seqqat, R., Chandel, N., Baker, K.M., Kumar, R. Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovascular Diabetology 2013; 12(-;-):U1-U13. >>> Aliskiren; benazeprilat; valsartan; PD123319; Saline; SC; Mice; 1004; Cardiovascular; petides; animal info (12 wks old, male, AT-KO); functionality of mp verified by echocardiography; pumps replaced every 4 weeks; enzyme inhibitor (renin); long-term study;.

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4. Bendroflumethiazide

2446 Lunau, H.E., Bak, M., Petersen, J.S., Shalmi, M., Marcussen, N., Christensen, S. Renal adaptations to continuous administration of furosemide and bendroflumethiazide in rats. Pharmacol. Toxicol 1994; 74(--):216-222. >>> Bendroflumethiazide; Furosemide; Lithium citrate; Ethanolamine; IP; rat; 2ML1; antihypertensive.

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5. Bisoprolol

13445 Sucharov, C.C., Hijmans, J.G., Sobus, R.D., Melhado, W.F.A., Miyamoto, S.D., Stauffer, B.L. beta-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. Journal of Applied Physiology 2013; 115(-7-):979-987. >>> Isoproterenol HCL; Bisoprolol; Nebivolol; Metoprolol, CGP2712A; Saline; DMSO; Ascorbic acid; SC; Mice; 1007D; 2001; Controls received mp w/ vehicle; animal info (FVB); 40% DMSO used for CGP20712A&nebivolol vehicle; post op. care (Carpofen 5 mg/kg); cardiovascular; antihypertensive;.

3894 Hamada, H., Hakamata, N., Ohsuzu, F., Nakamura, H. Age-related effects of norepinephrine on rat ventricular hypertrophy. Jpn. Heart J 1997; 38(-3-):433-443. >>> Norepinephrine HCl; Norepinephrine bitartrate; Bunazosin; Bisoprolol; SC; rat; 2002; controls received mp w/saline or norepinephrine; dose-response; antihypertensive; cardiovascular; 2 pumps implanted in each animal.

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6. Bunazosin

3894 Hamada, H., Hakamata, N., Ohsuzu, F., Nakamura, H. Age-related effects of norepinephrine on rat ventricular hypertrophy. Jpn. Heart J 1997; 38(-3-):433-443. >>> Norepinephrine HCl; Norepinephrine bitartrate; Bunazosin; Bisoprolol; SC; rat; 2002; controls received mp w/saline or norepinephrine; dose-response; antihypertensive; cardiovascular; 2 pumps implanted in each animal.

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7. Candesartan

16270 Villapol, S., Balarezo, M. G., Affram, K., Saavedra, J. M., Symes, A. J. Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Brain 2015; 138(-Pt 11-):3299-315. >>> Candesartan; Saline, Physiological; SC; mice; 1004; Controls received IP injection; animal info (C57BL/6NCr male mice weighing 20-25g); comparison of injection vs mp; comparison of injection vs mp; Dose (pg. 3301);.

14912 de Seigneux, S., Courbebaisse, M., Rutkowski, J.M., Wilhelm-Bals, A., Metzger, M., Khodo, S.N., Hasler, U., Chehade, H., Dizin, E., Daryadel, A., Stengel, B., NephroTest, Study Grp, Girardin, E., Prie, D., Wagner, C.A., Scherer, P.E., Martin, P.Y., Houillier, P., Feraille, E., de Seigneux, S. Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1608-1618. >>> Candesartan; SC; Rat; Animal info (male, Wistar or PAN nephrotic, 200-250g); cardiovascular;.

14875 Chang, T.T., Wu, T.C., Huang, P.H., Lin, C.P., Chen, J.S., Lin, L.Y., Lin, S.J., Chen, J.W., Chen, J.W. Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism. PLoS One 2015; 10(--):U1637-U1653. >>> Aliskiren; olmesartan; candesartan; PBS; Mice; 2006; Controls received mp w/ vehicle; animal info (male, FVB/NJNarl, 6 weeks old); ischemia (hind limb); diabetes; long-term study;.

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8. Captopril

15009 Li, W.C., Liu, J., Hammond, S.L., Tjalkens, R.B., Saifudeen, Z., Feng, Y.M., Feng, Y.M. Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 309(--):R138-R147. >>> Losartan; captopril; CAS92-78-4; CSF, artificial; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J); cardiovascular; CAS92-78-4 is a CREB-CBP interaction inhibitor;.

14958 Hardwick, J.C., Ryan, S.E., Powers, E.N., Southerland, E.M., Ardell, J.L., Hardwick, J.C. Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 309(--):R179-R188. >>> Captopril; losartan; CGP42112A; SC; Guinea Pig; 2ML4; Animal info (male, Hartley, 9 weeks old, 500-650g); pumps replaced every 3 weeks; cardiovascular; long-term study;.

14254 Lankhorst, S., Kappers, M.H.W., van Esch, J.H.M., Smedts, F.M.M., Sleijfer, S., Mathijssen, R.H.J., Baelde, H.J., Danser, A.H.J., van den Meiracker, A.H., van den Meiracker, A.H. Treatment of Hypertension and Renal Injury Induced by the Angiogenesis Inhibitor Sunitinib Preclinical Study. Hypertension 2014; 64(--):1282-U260. >>> Captopril; SC; Rat; 2ML2; Animal info (male, Wistar Kyoto, 280-300g); cardiovascular; antihypertensive; bp measured using radiotelemetry (DSI);.

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9. Clonidine

15142 Williams, B.A., Butt, M.T., Zeller, J.R., Coffee, S., Pippi, M.A., Williams, B.A. Multimodal Perineural Analgesia with Combined Bupivacaine-Clonidine-Buprenorphine-Dexamethasone: Safe In Vivo and Chemically Compatible in Solution. PAIN MEDICINE 2015; 16(--):186-198. >>> Bupivacaine; clonidine; dexamethasone; Saline; CSF/CNS (sciatic nerve); Rat; 2ML1; Controls received mp w/ vehicle; animal info (male, albino, CD[SD]); no stress (see pg. 192); post op. care (IM butorphanol tartrate 0.05 mg/kg, ceftiofur sodium 5 mg/kg); stability verified by (pg. 195); used polyurethane catheter 0.5mm ID 0.9 mmOD; pumps removed after 1 week; dose (66.6 ug/mL).

14861 Cao, W., Li, A.Q., Wang, L.L., Zhou, Z.M., Su, Z.X., Bin, W., Wilcox, C.S., Hou, F.F., Hou, F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

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10. Digotoxin

Q4508 Disdier,C., Devoy,J., Cosnefroy,A., Chalansonnet,M., Herlin-Boime,N., Brun,E., Lund,A., Mabondzo,A., Mabondzo,A. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat. Particle and Fibre Toxicology 2015; 12(--):U1-U20. >>> Atenolol; digoxin; prazosin; PEG200; DMSO; SC; Rat; 2001D; ; Animal info (male, Fisher F344, 8 weeks old, 180-250g); 50% PEG 200 used; 50% DMSO used;.

Q2688 Sjoegren,B., Parra,S., Heath,L.J., Atkins,K.B., Xie,Z.J., Neubig,R.R. Cardiotonic Steroids Stabilize Regulator of G Protein Signaling 2 Protein Levels. MOLECULAR PHARMACOLOGY 2012; 82(-3-):500-509. >>> Digoxin; DMSO; saline; SC; Mice; 2002; 7 days; Control animals received mp w/ vehicle; animal info (C57BL/6, male, 8-13 wks old); 0.4% DMSO used.

P5308 Huang,B.S., Kudlac,M., Kumarathasan,R., Leenen,F.H. Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation. Hypertension 1999/10; 34(-4 Pt 2-):733-738. >>> Digoxin; Antibody, Fab fragments; Gamma globulin; SC; CSF/CNS; Rat; 2002; 2ML2; 12-14 days; Controls received mp w/ gamma globulin solution; peptides; antihypertensive; digoxin infused SC via 2ML2 pumps; some animals received ICV Fab fragments concomitantly via 2002 pumps.

P5253 Manunta,P., Hamilton,J., Rogowski,A.C., Hamilton,B.P., Hamlyn,J.M. Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin. Hypertens Res 2000/9; 23 Suppl(--):S77-S85. >>> Ouabain; Ouabagenin; Digoxin; Digotoxin; PBS; SC; Rat; 2002; 5 weeks; Controls received mp/ vehicle; functionality of mp verified by residual volume; dose-response (p.581); pumps replaced every 14 days; antihypertensive; plasma levels of all agents verified by immunoassay; multiple pumps per animal (2) used simultaneously in one experiment.

P4750 Kimura,K., Manunta,P., Hamilton,B.P., Hamlyn,J.M. Different effects of in vivo ouabain and digoxin on renal artery function and blood pressure in the rat.. Hypertens Res 2000; 23(-Suppl-):S67-S76. >>> Ouabain; Digoxin; PBS, sterile; SC; rat; 5 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma levels of ouabain and digoxin; antihypertensive; ouabain and digoxin are sodium pump inhibitors.

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11. Digotoxin And Digoxin

16333 Eskiocak, U., Ramesh, V., Gill, J. G., Zhao, Z., Yuan, S. W., Wang, M., Vandergriff, T., Shackleton, M., Quintana, E., Johnson, T. M., DeBerardinis, R. J., Morrison, S. J. Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nat Commun 2016; 7(--):12336. >>> Digoxin; Promethylcellulose, Tween80, DMSO; SC; mice; Controls received mp w/ vehicle; animal info (NSG mice); 0.5% used Promethylcellulose, 0.2% Tween80 used, 5% DMSO; cancer (xenograft models); dose-response (pg. 14); Dose (10 mg/kg/day);.

16182 Sjogren, B., Parra, S., Atkins, K. B., Karaj, B., Neubig, R. R. Digoxin-Mediated Upregulation of RGS2 Protein Protects against Cardiac Injury. J Pharmacol Exp Ther 2016; 357(-2-):311-9. >>> Digoxin; DMSO; saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6J or RGS2 -/-, 8-18 weeks old); 0.04% DMSO used; dependence; pumps primed overnight in 37C saline; Dose (2 ug/kg/day);.

15016 Disdier, C., Devoy, J., Cosnefroy, A., Chalansonnet, M., Herlin-Boime, N., Brun, E., Lund, A., Mabondzo, A., Mabondzo, A. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat. Particle and Fibre Toxicology 2015; 12(--):U1-U20. >>> Atenolol; digoxin; prazosin; PEG 200; DMSO; SC; Rat; 2001D; Animal info (male, Fisher F344, 8 weeks old, 180-250g); 50% PEG 200 used; 50% DMSO used;.

12974 Sjoegren, B., Parra, S., Heath, L.J., Atkins, K.B., Xie, Z.J., Neubig, R.R. Cardiotonic Steroids Stabilize Regulator of G Protein Signaling 2 Protein Levels. MOLECULAR PHARMACOLOGY 2012; 82(-3-):500-509. >>> Digoxin; DMSO; saline; SC; Mice; 2002; Control animals received mp w/ vehicle; animal info (C57BL/6, male, 8-13 wks old); 0.4% DMSO used.

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12. Doxazosin

7279 Foster, HE Jr, Yono, M., Shin, D., Takahashi, W., Pouresmail, M., Afiatpour, P., Latifpour, J. Effects of chronic administration of doxazosin on alpha1-adrenoceptors in the rat prostate. Journal of Urology 2004; 172(-6-):2465-2470. >>> Doxazosin; DMSO; SC; Rat; Controls received mp w/ vehicle; dose-response (table 2); long-term study; cancer (prostatic hyperplasia); 50% DMSO; due to limitations in solubility mp was combined with oral dosing to deliver higher doses.

6995 Yono, M., Foster, HE Jr, Shin, D., Takahashi, W., Pouresmail, M., Latifpour, J. Doxazosin treatment causes differential alterations of alpha1-adrenoceptor subtypes in the rat kidney, heart and aorta. LIFE SCIENCES 2004; 75(-21-):2605-2614. >>> Doxazosin; DMSO; SC; Rat; Controls received mp w/ vehicle; functionality of mp verified by plasma doxazosin levels; long-term study; antihypertensive; 50% DMSO; doxazosin supplemented orally in drinking water.

3884 van Kleef, E.M., Smits, J.F.M., Schwartz, S.M., Daemen, M.J.A.P. Doxazosin blocks the angiotensin II-induced smooth muscle cell DNA synthesis in the media, but not in the neointima of the rat carotid artery after balloon injury. Cardiovasc. Res 1996; 31(--):324-330. >>> Angiotensin II, [val 5]; Doxazosin; Uridine, bromodeoxy-;; Saline; DMSO;; SC;; rat;; 2002; 2ML1;; controls received mp w/vehicle; 2ML1 pumps replaced after 1 week; antihypertensive; cardiovascular; multiple pumps per animal (2) - 1 w/drug, 1 w/BrdU.

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13. Enalapril

12506 Bae, S., Yalamarti, B., Ke, Q.G., Choudhury, S., Yu, H., Karumanchi, S.A., Kroeger, P., Thadhani, R., Kang, P.M. Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats. Cardiovascular Research 2011; 91(-4-):632-639. >>> Enalapril; SC; Rat; Controls received vehicle injections; animal info (HSS, Harlan Sprague Dawley); post op. care (meloxicam).

8413 Hamai, M., Iwai, M., Ide, A., Tomochika, H., Tomono, Y., Mogi, M., Horiuchi, M. Comparison of inhibitory action of candesartan and enalapril on brain ischemia through inhibition of oxidative stress. Neuropharmacology 2006; 51(-4-):822-828. >>> Candesartan; enalapril; IP; Mice; 1002; Dose-response (fig.1); cardiovascular; ischemia (cerebral, induced by MCAO); animal info (male, C57BL/6J, 10 wks old); neurology.

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14. Enalaprilat

13828 Kang, Y.M., Zhang, D.M., Yu, X.J., Yang, Q., Qi, J., Su, Q., Suo, Y.P., Yue, L.Y., Zhu, G.Q., Qin, D.N. Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. TOXICOLOGY AND APPLIED PHARMACOLOGY 2014; 274(-3-):436-444. >>> Angiotensin II; enalaprilat; Saline; cerebrospinal fluid, artificial; SC; CSF/CNS (paraventricular nucleus); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, adult, 275-300g); functionality of mp verified by increased bp; post op. care (buprenorphine); tissue perfusion (bilateral paraventricular nucleus); cardiovascular; peptides; antihypertensive; bp measured using tail-cuff; pumps primed in 37C saline; used wound clips; enalaprilat is an ACE inhibitor; Plastics One bilateral PVN cannulae; bilaterial infusion.

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15. Eprosartan

10778 Mukaddam-Daher, S., Menaouar, A., Paquette, P.A., Jankowski, M., Gutkowska, J., Gillis, M.A., Shi, Y.F., Calderone, A., Tardif, J.C. Hemodynamic and Cardiac Effects of Chronic Eprosartan and Moxonidine Therapy in Stroke-Prone Spontaneously Hypertensive Rats. Hypertension 2009; 53(-5-):775-U58. >>> Moxonidine; eprosartan; Saline; NaOH; HCl; SC; Rat; 2004; 2ML4; Controls received mp w/ vehicle; animal info (SP-SHR, 14 wks old, 250-275 g); antihypertensive; pumps replaced after 4 weeks; long-term study; multiple pumps per animal (2); moxonidine or eprosartan were infused separately or in combination.

7791 Chen, Y., Currie, R.W. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. INFLAMMATION RESEARCH 2005; 54(-8-):338-343. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (jugular); Rat; 2001; 2ML2; Controls received mp w/ vehicle or sham HS surgery; cardiovascular; peptides; animal info (male, Sprague-Dawley 280-310 g).

7764 Karram, T., Abbasi, A., Keidar, S., Golomb, E., Hochberg, I., Winaver, J., Hoffman, A., Abassi, Z. Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure. American Journal of Physiology-Heart and Circulatory Physiology 2005; 289(-4-):H1351-H1358. >>> Spironolactone; eprosartan; PEG 400; sodium bicarbonate; IP; Rat; 2ML2; 2ML4; Controls received mp w/ vehicle; functionality of mp verified by plasma levels (H1353); cardiovascular; animal info (male, Wistar 300 g); aldosterone antagonist; ANG II receptor antagonist.

7566 Dendorfer, A., Dominiak, P., Tempel, K., Raasch, W. Peripheral sympatholytic actions of four AT1 antagonists: are they relevant for-long-term antihypertensive efficacy?. Journal of Hypertension 2005; 23(-10-):1861-1867. >>> Candesartan; losartan; eprosartan; irbesartan; NaOH; IP; Rat; 2ML4; Controls received mp w/ vehicle; functionality of mp verified by blood pressure taken; dose-response (fig. 1); cardiovascular; antihypertensive; animal info (male, SHR, 10 wk old, 250-280 g).

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16. Felodipine

5313 Zhou, X.J., Zhou, X.J., Vaziri, N.D. Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapy. NEPHROLOGY DIALYSIS TRANSPLANTATION 2002; 17(--):992-997. >>> Felodipine; Rat; Cardiovascular; antihypertensive; calcium channel blocker.

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17. Furosemide

14980 Hunter, R.W., Ivy, J.R., Flatman, P.W., Kenyon, C.J., Craigie, E., Mullins, L.J., Bailey, M.A., Mullins, J.J., Hunter, R.W. Hypertrophy in the Distal Convoluted Tubule of an 11-Hydroxysteroid Dehydrogenase Type 2 Knockout Model. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1537-1548. >>> Uridine, bromodeoxy-; furosemide; DMSO; SC; Mice; 1007D; 2001; Animal info (WT or Hsd1 1b2 -/-); 50% DMSO used; pumps primed overnight in 37C saline;.

13456 Schiessl, I.M., Rosenauer, A., Kattler, V., Minuth, W.W., Oppermann, M., Castrop, H. Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2. American Journal of Physiology-Renal Physiology 2013; 305(-8-):F1139-F1148. >>> Furosemide; Angiotensin II; NaCl; Acetic Acid; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, C57BL6, 8-10 weeks); functionality of mp verified by increased arterial BP; cardiovascular; bp measured using tail-cuff;.

13126 Seidel, S., Neymeyer, H., Kahl, T., Roeschel, T., Mutig, K., Flower, R., Schnermann, J., Bachmann, S., Paliege, A. Annexin A1 modulates macula densa function by inhibiting cyclooxygenase 2. American Journal of Physiology-Renal Physiology 2012; 303(-6-):F845-F854. >>> Furosemide; Rat; 2ML1; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male).

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18. Guanabenz

15893 Vieira, F. G., Ping, Q., Moreno, A. J., Kidd, J. D., Thompson, K., Jiang, B., Lincecum, J. M., Wang, M. Z., De Zutter, G. S., Tassinari, V. R., Levine, B., Hatzipetros, T., Gill, A., Perrin, S. Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. PLoS One 2015; 10(-8-):e0135570. >>> Guanabenz acetate; Ethanol; water; propylene glycol; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (SOD1-G93A); pumps replaced every 28 days; dose-response (pg 4); neurodegenerative (amyotrophic lateral sclerosis); post op. care (antibiotic ointment; buprenorphine 0.1 mg/kg); long-term study; used lot#10284-12; Dose (0.45, 1.5, or 4.5 mg/kg/day);.

2540 Hamilton, C.A., Yakubu, M.A., Howie, C.A., Reid, J.L. Do centrally-acting antihypertensive drugs act at non-adrenergic as well as alpha-2 adrenoceptor sites?. Clin. and Exper. Hyper. -Theory and Practice 1992; A14(-5-):815-835. >>> Guanabenz; Clonidine; Rilmenidine; Water, sterile; Ethanol; IV (femoral); rabbit; controls received mp w/ vehicles; agents are antihypertensives; mp and catheter embedded in thigh muscle; antihypertensive.

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19. Hydralazine

14987 Kawahata, H., Sotobayashi, D., Aoki, M., Shimizu, H., Nakagami, H., Ogihara, T., Morishita, R., Aoki, M. Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. HYPERTENSION RESEARCH 2015; 38(--):382-393. >>> Angiotensin II; olmesartan; hydralazine; Saline; sodium bicarbonate; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (female, C57BL/6NJ, 20-22g); dose-response (p. 385); cardiovascular; antihypertensive; peptides; bp measured using tail cuff;.

14861 Cao, W., Li, A.Q., Wang, L.L., Zhou, Z.M., Su, Z.X., Bin, W., Wilcox, C.S., Hou, F.F., Hou, F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

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20. Hydrochlorothiazide

15835 Kathryn R. Walsh, Jill T. Kuwabara, Joon W. Shim, and Richard D. Wainford. Norepinephrine-evoked salt-sensitive hypertension requires impaired renalsodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 2016; 310(--):R115-R124. >>> Norepinephrine; hydrochlorothiazide; losartan; Saline; DMSO; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 275-299g); post op. care (penicillin 0.3 ml IM 300,000 units/ml); cardiovascular; Dose (losartan 3 mg/kg/day, NE 600 ng/min; HCTZ 4 mg/kg/day);.

12425 Ashek, A., Menzies, R.I., Mullins, L.J., Bellamy, C.O.C., Harmar, A.J., Kenyon, C.J., Flatman, P.W., Mullins, J.J., Bailey, M.A. Activation of Thiazide-Sensitive Co-Transport by Angiotensin II in the cyp1a1-Ren2 Hypertensive Rat. PLoS One 2012; 7(-4-):U1890-U1899. >>> Hydrochlorothiazide; spironolactone; losartan; Saline; DMSO; Rat; 2ML1; Controls received mp w/ vehicle; animal info (male, cyp1a1-Ren2 TGR, Fischer 344, 12-14 wks old); 50% DMSO used.

9752 Jang, H.R., Kim, S., Heo, N.J., Lee, J.H., Kim, H.S., Nielsen, S., Jeon, U.S., Oh, Y.K., Na, K.Y., Joo, K.W., Han, J.S. Effects of Thiazide on the Expression of TRPV5, Calbindin-D28K, and Sodium Transporters in Hypercalciuric Rats. Journal of Korean Medical Science 2009; 24(-;-):S161-S169. >>> Hydrochlorothiazide; Ethanolamine; SC; Rat; 2ML1; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 6 wks old, 160-180 g.).

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21. Imidapril

12153 Ishibashi, R., Aoki, T., Nishimura, M., Miyamoto, S. Imidapril Inhibits Cerebral Aneurysm Formation in an Angiotensin-Converting Enzyme-Independent and Matrix Metalloproteinase-9-Dependent Manner. Neurosurgery 2012; 70(-3-):722-730. >>> Imidapril hydrochloride; DMSO; IP; Rat; 2ML4; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, 7 wks old); enzyme inhibitor (ACE, angiotensin converting enzyme).

5430 Kurosawa, Y., Katoh, M., Doi, H., Narita, H. Tissue Angiotensin-converting enzyme activity plays an important role in pressure overload-induced cardiac fibrosis in rats. J Cardiovasc. Pharmacol 2002; 39(-4-):600-609. >>> Imidapril; Saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; cardiovascular; enzyme inhibitor; imidapril is an angiotensin-converting enzyme inhibitor.

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22. Isoproterenol

16247 Shimura, D., Kusakari, Y., Sasano, T., Nakashima, Y., Nakai, G., Jiao, Q., Jin, M., Yokota, T., Ishikawa, Y., Nakano, A., Goda, N., Minamisawa, S. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol 2016; 310(-1-):H92-103. >>> Isoproterenol; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (SLN mutants, male and female; 3-6 months old); functionality of mp verified by ECG (echocardiography); cardiovascular; antihypertensive; Isoflurane used; Dose (30 ug/g/day);.

16227 Parvatiyar, M. S., Marshall, J. L., Nguyen, R. T., Jordan, M. C., Richardson, V. A., Roos, K. P., Crosbie-Watson, R. H. Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy. J Am Heart Assoc 2015; 4(-12-):. >>> Isoproterenol; saline; SC; mice; Controls received mp w/ vehicle; animal info (SSPN-null mice, Male WT C57BL/6J mice, 12- to 14-month-old); functionality of mp verified by ECG (echocardiography); cardiovascular; Isoflurane used; beta-adrenergic challenge; Dose (0.8 mg/day);.

16109 Correll, R. N., Goonasekera, S. A., van Berlo, J. H., Burr, A. R., Accornero, F., Zhang, H., Makarewich, C. A., York, A. J., Sargent, M. A., Chen, X., Houser, S. R., Molkentin, J. D. STIM1 elevation in the heart results in aberrant Ca(2)(+) handling and cardiomyopathy. J Mol Cell Cardiol 2015; 87(--):38-47. >>> Isoproterenol; Angiotensin II; Phenylephrine; saline; SC; mice; 2002; Controls received mp w/ vehicle; animal info: STIM1 TG mice; functionality of mp verified by echocardiograph (ECG); cardiovascular; Dose: isoproterenol (60 mg/kg/d); angiotensin II (432Ǩg/kg/d) with phenylephrine (100 mg/kg/d),.

16103 Cattin, M. E., Wang, J., Weldrick, J. J., Roeske, C. L., Mak, E., Thorn, S. L., DaSilva, J. N., Wang, Y., Lusis, A. J., Burgon, P. G. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem 2015; 290(-44-):26699-714. >>> Isoproterenol; saline; SC; IP; mice; 1004; Controls received mp w/ vehicle; animal info: 12-week-old female and male Mlip+/+ and Mlip-/- mice; functionality of mp verified by Transthoracic echocardiography; stress/adverse reaction: (see pg. 26709 );“We hypothesized that this could be due to the stress of surgery, the inflammation resulting from the healing process, and/or the stress caused by the subcutaneous micro-osmotic pump;"cardiovascular; antihypertensive; Dose: (40mg/kg/day).

16101 Capel, R. A., Bolton, E. L., Lin, W. K., Aston, D., Wang, Y., Liu, W., Wang, X., Burton, R. A., Bloor-Young, D., Shade, K. T., Ruas, M., Parrington, J., Churchill, G. C., Lei, M., Galione, A., Terrar, D. A. Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic beta-Adrenoceptor Signaling in the Heart. J Biol Chem 2015; 290(-50-):30087-98. >>> isoproterenol; Saline; SC; mice; Controls received mp w/ vehicle; animal info: 8–10-week-old WT and Tpcn2_/_ mice; functionality of mp verified by in vivo electrocardiographic analysis; cardiovascular; hypertrophy; Dose: 10 mg/kg/day.

16058 Wang, J. J., Rau, C., Avetisyan, R., Ren, S., Romay, M. C., Stolin, G., Gong, K. W., Wang, Y., Lusis, A. J. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet 2016; 12(-7-):e1006038. >>> Isoproterenol; IP; Mice; 1004; animal info (used 104 different mouse strains, see pg 4 for list); cardiovascular; Dose (30 mg/kg/day);.

15974 Kritzer, M. D., Li, J., Passariello, C. L., Gayanilo, M., Thakur, H., Dayan, J., Dodge-Kafka, K., Kapiloff, M. S. The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail 2014; 7(-4-):663-72. >>> Isoproterenol; mice; animal info (C57BL/76 mice; 8-week-old mAKAPfl/fl); ischemia (cardiac); behavioral testing (physiological hypertrophy induced with 5-wk swimming regimen, Hargreaves test); tissue perfusion (heart); cardiovascular; Iso aka Isoproterenol; Dose: 60 mg/kg/day.

15827 Tiju Theccanat, Jennifer L. Philip, Abdur M. Razzaque, Nicholas Ludmer, Jinju Li, Xianyao Xu, Shahab A. Akhter. Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4. Cellular Signalling 2016; 28(--):190-203. >>> Angiotensin II; isoproterenol; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, C57BL-6N, 6 weeks old); cardiovascular; peptides; Dose (Iso 17 mg/kg/day; Ang II 1.8 mg/kg/day);.

15824 Marcus R. Streit,, Celine S. Weiss, Sören Meyer, Marco M. Ochs, Marco Hagenmueller, Johannes H. Riffel, Sebastian J. Buss, Thomas Heger, Hugo A. Katus, Stefan E. Hardt. Cardiac Effects of Attenuating Gsǝ-Dependent Signaling. PLoS One 2016; 10(--):1-19. >>> Isoproterenol HCl; Saline, acidified isotonic; SC; Mice; 2002; Controls received mp w/ vehicle; cardiovascular; Dose (30 ug/g/day);.

15819 Analyne M. Schroeder, Huei Bin Wang, Saemi Park, Maria C. Jordan, Fuying Gao, Giovanni Coppola, Michael C. Fishbein, Kenneth P. Roos, Cristina A. Ghiani, Christopher S. Colwell. Cardiac Dysfunction in the BACHD MouseModel of Huntington’s Disease. PLoS One 2016; 11(-1-):1-25. >>> Isoproterenol; Saline; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (BACHD or WT, 2-3 months old); neurodegenerative (Huntington's Disease); long-term study; cardiovascular; Dose (0.24, 0.48, 0.97 mg/day);.

15247 Zheng, Y., Kong, Y., Li, F. Kruppel-like transcription factor 11 (KLF11) overexpression inhibits cardiac hypertrophy and fibrosis in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2014; 443(-2-):683-688. >>> Isoproterenol; angiotensin II; IP; Mice; 2002; Animal info (male, C57BL6); cardiovascular; peptides;.

15212 Gaspard, G.J., MacLean, J., Rioux, D., Pasumarthi, K.B.S. A novel beta-adrenergic response element regulates both basal and agonist-induced expression of cyclin-dependent kinase 1 gene in cardiac fibroblasts. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2014; 306(-6-):C540-C550. >>> Isoproterenol; Saline; Mice; 2001; Controls received mp w/ vehicle; animal info (male, CD1, 11-13 weeks old); cardiovascular;.

15266 Grimm, M., Ling, H.Y., Willeford, A., Pereira, L., Gray, C.B.B., Erickson, J.R., Sarma, S., Respress, J.L., Wehrens, X.H.T., Bers, D.M., Brown, J.H., Brown, J.H. CaMKIIdelta mediates beta-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic beta-adrenergic stimulation. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 85(--):282-291. >>> Isoproterenol; SC; Mice; 2004; Animal info (male, Black Swiss, 8-12 weeks old); comparison of injection vs mp; cardiovascular;.

15190 Althurwi, H.N., Elshenawy, O.H., El-Kadi, A.O.S. Fenofibrate Modulates Cytochrome P450 and Arachidonic Acid Metabolism in the Heart and Protects Against Isoproterenol-induced Cardiac Hypertrophy. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 2014; 63(-2-):167-177. >>> Isoproterenol; Saline; Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); cardiovascular;.

15170 Zhang, H.M., Fu, J.L., Hamilton, R., Diaz, V., Zhang, Y.Q., Zhang, H.M. The mammalian target of rapamycin modulates the immunoproteasome system in the heart. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 86(--):158-167. >>> Isoproterenol; Saline; SC; Mice; 2001; Controls received mp w/ vehicle; animal info (C57BL6, 6 months old); cardiovascular; dose: 2 mg/kg/day.

15169 Zha, Z.Y., Han, X.R., Smith, M.D., Liu, Y., Giguere, P.M., Kopanja, D., Raychaudhuri, P., Siderovski, D.P., Guan, K.L., Lei, Q.Y., Xiong, Y., Guan, K.L. A Non-Canonical Function of Gbeta as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. MOLECULAR CELL 2015; 58(--):794-803. >>> Isoproterenol; NaCl; acetic acid; SC; Mice; 2001; Animal info (male, 2 months old); cardiovascular; dose: 8.7 mg/kg/day.

15154 Yang, L., Ni, L., Duan, Q.L., Wang, X.X., Chen, C., Chen, S., Chaugai, S., Zeldin, D.C., Tang, J.R., Wang, D.W., Tang, J.R. CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. PROSTAGLANDINS&OTHER LIPID MEDIATORS 2015; 116(--):64-75. >>> Isoproterenol; angiotensin II; Ascorbic acid; saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, CYP2J2 Tg or WT C57BL6); 0.002% ascorbic acid used; cardiovascular; immunology; peptides; bp measured using catheter;.

15113 Thoonen, R., Ernande, L., Cheng, J., Nagasaka, Y., Yao, V., Miranda-Bezerra, A., Chen, C., Chao, W., Panagia, M., Sosnovik, D.E., Puppala, D., Armoundas, A.A., Hindle, A., Bloch, K.D., Buys, E.S., Scherrer-Crosbie, M., Scherrer-Crosbie, M. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 84(--):202-211. >>> Isoproterenol; SC; Mice; 1002; Controls received mp w/ saline; animal info (C57BL6J, 12-14 weeks old); cardiovascular; bp meaured using tail cuff;.

15068 Samant, S.A., Pillai, V.B., Sundaresan, N.R., Shroff, S.G., Gupta, M.P., Gupta, M.P. Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity. JOURNAL OF BIOLOGICAL CHEMISTRY 2015; 290(--):15559-15569. >>> Phenylephrine; isoproterenol; NaCl; acetic acid; Mice; 2002; Animal info (male, CD1, 20-30g, adult); cardiovascular;.

15061 Planavila, A., Redondo-Angulo, I., Ribas, F., Garrabou, G., Casademont, J., Giralt, M., Villarroya, F., Planavila, A. Fibroblast growth factor 21 protects the heart from oxidative stress. CARDIOVASCULAR RESEARCH 2015; 106(--):19-31. >>> Isoproterenol; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, Fgf21 null or WT, 4 months old); cardiovascular;.

15059 Pillai, V.B., Samant, S., Sundaresan, N.R., Raghuraman, H., Kim, G., Bonner, M.Y., Arbiser, J.L., Walker, D.I., Jones, D.P., Gius, D., Gupta, M.P., Gupta, M.P. Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nature Communications 2015; 6(--):U15-U30. >>> Isoproterenol; IP; Mice; Animal info (male, CD-1, 30g, 6-8 weeks old); cardiovascular;.

15952 Major, J. L., Salih, M., Tuana, B. S. Interplay between the E2F pathway and beta-adrenergic signaling in the pathological hypertrophic response of myocardium. J Mol Cell Cardiol 2015; 84(--):179-90. >>> Isoproterenol HCl; Saline; SC; Mice; 2001D; Controls received mp w/ vehicle; animal info (B6C3F1); cardiovascular; Dose (6.1 or 12.2 mg/kg/day);.

15040 Mirtschink, P., Krishnan, J., Grimm, F., Sarre, A., Hoerl, M., Kayikci, M., Fankhauser, N., Christinat, Y., Cortijo, C., Feehan, O., Vukolic, A., Sossalla, S., Stehr, S.N., Ule, J., Zamboni, N., Pedrazzini, T., Krek, W., Krek, W. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. NATURE 2015; 522(--):444-+. >>> Isoproterenol; Mice; 2002; Animal info (male, C57BL6J, 9-10 weeks old); cardiovascular;.

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23. Ketanserin

10019 Lairez, O., Calise, D., Bianchi, P., Ordener, C., Spreux-Varoquaux, O., Guilbeau-Frugier, C., Escourrou, G., Seif, I., Roncalli, J., Pizzinat, N., Galinier, M., Parini, A., Mialet-Perez, J. Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. Journal of Molecular and Cellular Cardiology 2009; 46(-4-):587-595. >>> Ketanserin; M100907; DMSO; saline; hydrochloric acid; IP; Mice (transgenic); Controls received mp w/ vehicle; animal info (male, Tg8 MAO-A KO, wt, 10 wks old); 10% DMSO used; 5-HT2A receptor antagonists.

6055 Jorgensen, H., Knigge, U., Kjaer, A., Warberg, J. Serotonergic involvement in stress-induced vasopressin and oxytocin secretion. European Journal of Endocrinology 2002; 147(-6-):815-824. >>> Ketanserin; Ly-53857; ICS-205930; Saline; CSF/CNS; Rat; 2ML4; Stylet used; pump implanted IP; drugs were 5-ht antagonists.

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24. Losartan

16221 Oller, J., Alfranca, A., Mendez-Barbero, N., Villahoz, S., Lozano-Vidal, N., Martin-Alonso, M., Arroyo, A. G., Escolano, A., Armesilla, A. L., Campanero, M. R., Redondo, J. M. C/EBPbeta and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol 2015; 35(-19-):3409-22. >>> Vascular Endothelial Growth Factor, Angiotensin II, Losartan, Cyclosporine; Saline; SC; Mice; Controls received mp w/ vehicle; animal info (Calcineurin (CN) B1 (Cnb1_/fl) conditional knockout mice, C57BL/6 mice); dose-response; vegf aka vascular endothelial growth factor; Dose (VEGF 25 ug/kg/day, AngII 1 ug/kg/min, CsA 5 mg/kg/day, Losartan 10 mg/kg/day);.

15915 Kelloniemi, A., Aro, J., Napankangas, J., Koivisto, E., Mustonen, E., Ruskoaho, H., Rysa, J. TSC-22 up-regulates collagen 3a1 gene expression in the rat heart. BMC Cardiovasc Disord 2015; 15(--):122. >>> Angiotensin II; losartan; saline; SC; Rat; Controls received mp w/ vehicle; animal info (male, SHR or WKY, 12-20 months old); cardiovascular; peptides;.

15835 Kathryn R. Walsh, Jill T. Kuwabara, Joon W. Shim, and Richard D. Wainford. Norepinephrine-evoked salt-sensitive hypertension requires impaired renalsodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 2016; 310(--):R115-R124. >>> Norepinephrine; hydrochlorothiazide; losartan; Saline; DMSO; SC; Rat; 2ML2; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 275-299g); post op. care (penicillin 0.3 ml IM 300,000 units/ml); cardiovascular; Dose (losartan 3 mg/kg/day, NE 600 ng/min; HCTZ 4 mg/kg/day);.

15152 Yang, J.M., Sun, Y., Dong, M., Yang, X.Y., Meng, X., Niu, R.R., Guan, J., Zhang, Y., Zhang, C., Zhang, Y. Comparison of angiotensin-( 1-7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice. ATHEROSCLEROSIS 2015; 240(--):544-549. >>> Angiotensin (1-7); losartan; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, ApoE -/-, 8 weeks old, 20-22g); cardiovascular; antihypertensive; peptides; bp measured using tail cuff;.

15955 Liu, Q., Wang, T., Yu, H., Liu, B., Jia, R. Interaction between interleukin-1 beta and angiotensin II receptor 1 in hypothalamic paraventricular nucleus contributes to progression of heart failure. J Interferon Cytokine Res 2014; 34(-11-):870-5. >>> Losartan; interleukin-1, beta; CSF, articifial; CSF, artificial; CSF/CNS; rats; 2004; Controls: sham rats w/ no treatment; rats given artificial CSF; animal info (Male Sprague–Dawley rats, 200–250 g); functionality of mp verified by echocardiography and plasma levels; bilateral cannula used; Plastics One double cannula; cardiovascular; heart failure; brain tissue distribution; Cannula placement verified via brain coordinates; LOS aka losartan; IL-1B aka interleukin-1B; Dose: LOS 200ug/day, IL-1B 1ug/day; Resultant plasma level (pg 872-874); Brain coordinates; pg. 871 (2.0mm posterior to the bregma and 8.5mm ventral from the skull surface).

15087 Song, M.A., Dasgupta, C., Zhang, L.B., Zhang, L.B. Chronic Losartan Treatment Up-Regulates AT(1)R and Increases the Heart Vulnerability to Acute Onset of Ischemia and Reperfusion Injury in Male Rats. PLoS One 2015; 10(--):U1154-U1168. >>> Losartan; SC; Rat; 2ML4; Controls received mp w/ Saline; animal info (male, Sprague Dawley, 6 months old); ischemia (cardiac); cardiovascular; antihypertensive; bp measured using femoral catheter;.

15009 Li, W.C., Liu, J., Hammond, S.L., Tjalkens, R.B., Saifudeen, Z., Feng, Y.M., Feng, Y.M. Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 309(--):R138-R147. >>> Losartan; captopril; CAS92-78-4; CSF, artificial; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J); cardiovascular; CAS92-78-4 is a CREB-CBP interaction inhibitor;.

14958 Hardwick, J.C., Ryan, S.E., Powers, E.N., Southerland, E.M., Ardell, J.L., Hardwick, J.C. Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2015; 309(--):R179-R188. >>> Captopril; losartan; CGP42112A; SC; Guinea Pig; 2ML4; Animal info (male, Hartley, 9 weeks old, 500-650g); pumps replaced every 3 weeks; cardiovascular; long-term study;.

14929 Erdos, B., Backes, I., McCowan, M.L., Hayward, L.F., Scheuer, D.A., Erdos, B. Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H612-H622. >>> Losartan; Saline; CSF/CNS; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 7 weeks old); pumps replaced every 2 weeks; cardiovascular; bp measured using radiotelemetry; used guide infusion cannula from Plastics One;.

14861 Cao, W., Li, A.Q., Wang, L.L., Zhou, Z.M., Su, Z.X., Bin, W., Wilcox, C.S., Hou, F.F., Hou, F.F. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2015; 26(--):1619-1633. >>> Losartan; clonidine; tempol; hydralazine; PBS; Cerebrospinal fluid, artificial; CSF/CNS; intragastric; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 5 weeks old, 5/6x nephrectomy); dose-response (pg 1627); cardiovascular; bp measured using catheter;.

14294 Marvar, P.J., Goodman, J., Fuchs, S., Choi, D.C., Banerjee, S., Ressler, K.J., Marvar, P.J. Angiotensin Type 1 Receptor Inhibition Enhances the Extinction of Fear Memory. Biological Psychiatry 2014; 75(--):864-872. >>> Losartan; Saline, isotonic sterile; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6J, 3-4 months old); behavioral testing (elevated plus maze); cardiovascular; bp measured using radiotelemetry;.

14682 Carrillo-Sepulveda, M.A., Keen, H.L., Davis, D.R., Grobe, J.L., Sigmund, C.D., Sigmund, C.D. Role of Vascular Smooth Muscle PPARgamma in Regulating AT(1) Receptor Signaling and Angiotensin II-Dependent Hypertension. PLoS One 2014; 9(--):U221-U226. >>> Losartan; SC; Mice (transgenic); 1002; Controls received mp w/ saline; animal info (male, PPARy P467L, 4-5 months old); cardiovascular; bp measured using radiotelemetry (DSI); antihypertensive;.

14638 Katsuki, M., Hirooka, Y., Kishi, T., Sunagawa, K., Hirooka, Y. Decreased proportion of Foxp3(+)CD4(+) regulatory T cells contributes to the development of hypertension in genetically hypertensive rats. Journal of Hypertension 2015; 33(--):773-783. >>> Losartan; CSF, artificial; CSF/CNS; Rat; Control animals received mp w/ vehicle; animal info (male, SHRSP, WKY); ALZET brain infusion kit 2 used.

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25. Metoprolol

16030 Ito, N., Ito, K., Koshimichi, H., Hisaka, A., Honma, M., Igarashi, T., Suzuki, H. Contribution of protein binding, lipid partitioning, and asymmetrical transport to drug transfer into milk in mouse versus human. Pharm Res 2013; 30(-9-):2410-22. >>> acetaminophen, cephalothin sodium salt, clindamycin hydrochloride, disopyramide phosphate salt, labetalol hydrochloride, nitrofurantoin +-propranolol hydrochloride, terbutaline hemisulfate salt, verapamil hydrochloride, Acyclovir, alprazolam, atenolol, anhydrous caffeine, cefotaxime sodium salt, cephapirin sodium salt, diltiazem hydrochloride, metronidazole, nitrazepam, prednisolone, 6-propyl-2-thiouracil, trazadone hydrochloride, chloramphenicol, cimetidine, theophylline, fluconazole, metoprolol, mirtazapine, praziquantel, quetiapine fumarate, triprolidine hydrochloride, metformin, moclobemide.; DMSO; water; IP; mice; 1003D; animal info: lactating mice, postnatal age of 14 days; functionality of mp verified by measurement of drug concentration in milk and plasma; mp were used to infuse study lactational drug transfer..

14446 Ulleryd, M.A., Bernberg, E., Yang, L.J., Bergstroem, G.M.L., Johansson, M.E., Johansson, M.E. Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE(-/-) Mice. BIOMED RESEARCH INTERNATIONAL 2014; ;(--):U1-U7. >>> Metoprolol; Saline; SC; Mice; 1002; 2006; Animal info (male, C57BL6J or ApoE -/-, 12 weeks old); functionality of mp verified by plasma levels with mass spectrometry; pumps replaced every 6 weeks; cardiovascular; immunology; antihypertensive;.

13679 Saran, V., Sharma, V., Wambolt, R., Yuen, V.G., Allard, M., McNeill, J.H., McNeill, J.H. Combined metoprolol and ascorbic acid treatment prevents intrinsic damage to the heart during diabetic cardiomyopathy. Canadian Journal of Physiology and Pharmacology 2014; 92(--):827-837. >>> Metoprolol; SC; Rat; 2ML4; 2006; Animal info (male, Wistar, 200-220 g).

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26. Minoxidil

P1899 Kuo,Y.-J., Keeton,T.K. Captopril increases norepinephrine spillover rate in conscious spontaneously hypertensive rats. J.Pharmacol.Exp.Ther. 1991; 258(-1-):223-231. >>> Minoxidil HCl; Captopril; Enalaprilat; Acetic acid; Ethanol; Propylene glycol; Saline; Water; SC; rat; 5 days; no comment posted; antihypertensive.

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27. Minoxidil HCl

1895 Kuo, Y.-J., Keeton, T.K. Captopril increases norepinephrine spillover rate in conscious spontaneously hypertensive rats. J. Pharmacol. Exp. Ther 1991; 258(-1-):223-231. >>> Minoxidil HCl; Captopril; Enalaprilat; Acetic acid; Ethanol; Propylene glycol; Saline; Water; SC; rat; no comment posted; antihypertensive.

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28. Moxonidine

11157 Stabile, A.M., Aceros, H., Stockmeyer, K., Rahman, A.A.A., Noiseux, N., Mukaddam-Daher, S. Functional and molecular effects of imidazoline receptor activation in heart failure. LIFE SCIENCES 2011; 88(-11-12-):493-503. >>> Moxonidine; Saline, normal; SC; Hamster; 2ML4; Controls received mp w/ vehicle; animal info (BIO 14.6, male, 6, 10 m old).

10778 Mukaddam-Daher, S., Menaouar, A., Paquette, P.A., Jankowski, M., Gutkowska, J., Gillis, M.A., Shi, Y.F., Calderone, A., Tardif, J.C. Hemodynamic and Cardiac Effects of Chronic Eprosartan and Moxonidine Therapy in Stroke-Prone Spontaneously Hypertensive Rats. Hypertension 2009; 53(-5-):775-U58. >>> Moxonidine; eprosartan; Saline; NaOH; HCl; SC; Rat; 2004; 2ML4; Controls received mp w/ vehicle; animal info (SP-SHR, 14 wks old, 250-275 g); antihypertensive; pumps replaced after 4 weeks; long-term study; multiple pumps per animal (2); moxonidine or eprosartan were infused separately or in combination.

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29. Nicardipine

10839 Ingram, E.A., Toyoda, I., Wen, X.L., Buckmaster, P.S. Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy. Epilepsia 2009; 50(-1-):56-64. >>> Nicardipine; FK-506; cyclosporin A; DMSO; ethanol; fluorescein; CSF/CNS (dorsal left dentate gyrus); Rat; 2004; Controls were treated identically without status epilepticus; animal info (34-52 day old, male, Sprague-Dawley, status epilepticus); functionality of mp verified by fluorescein labeling; ALZET brain infusion kit 2 used; 50% DMSO used; 15% ethanol used.

10260 Fossat, P., Dobremez, E., Bouali-Benazzouz, R., Favereaux, A., Bertrand, S.S., Kilk, K., Leger, C., Cazalets, J.R., Langel, U., Landry, M., Nagy, F. Knockdown of L Calcium Channel Subtypes: Differential Effects in Neuropathic Pain. Journal of Neuroscience 2010; 30(-3-):1073-1085. >>> Nicardipine; CSF/CNS (intrathecal); Rat; 1007D; Animal info (adult, Wistar, 250-300 g.); PE-10 catheter used.

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30. Nifedipine

13425 Yan, J.G., Zhang, L.L., Agresti, M., LoGiudice, J., Yan, Y.H., Wang, Z.Y., Sanger, J.R., Matloub, H.S. The effect of calcium modulating agents on peripheral nerve recovery after crush. Journal of Neuroscience Methods 2013; 217(-1-2-):54-62. >>> Nifedipine; calcitonin; CSF/CNS (sciatic nerve); Rat; 2006; Controls received mp w/ saline or sham only; animal info (3 month old, male, Sprague-Dawley 250-300g); functionality of mp verified by decrease in calcium levels; peptides; Picture of MP p56, Fig1A. MP Pump setup p56, Fig1B;.

12537 Tian, Z., Miyata, K., Tabata, M., Yano, M., Tazume, H., Aoi, J., Takahashi, O., Araki, K., Kawasuji, M., Oike, Y. Nifedipine increases energy expenditure by increasing PGC-1alpha expression in skeletal muscle. HYPERTENSION RESEARCH 2011; 34(-11-):1221-1227. >>> Nifedipine; PEG 400; ethanol; water; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, eNOS KO); 15% PEG 400 used; 15% ethanol used; long-term study.

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31. Nilvadipine

3526 Kawamura, S., Li, Y., Shirasawa, M., Yasui, N., Fukasawa, H. Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats. Neurol. Med. Chir 1996; 36(--):151-155. >>> Nilvadipine; PEG; SC; rat; 2ML1; controls received vehicle infusion; antihypertensive; ischemia (cerebral).

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32. PD123319

16202 Liu, Y., Li, B., Wang, X., Li, G., Shang, R., Yang, J., Wang, J., Zhang, M., Chen, Y., Zhang, Y., Zhang, C., Hao, P. Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor. Mol Med 2015; 21(--):626-36. >>> Angiotensin (1-7), A779, PD123319; saline; SC; mice; Controls received mp w/ vehicle; animal info: Male BALB/c mice (6–8 wks old); functionality of mp verified by measurement of tumor volumes; cancer (Hepatocellular Carcinoma); peptides; Dose: (200 ng/kg/min) Ang-(1–7), (800 ng/kg/min) Ang-(1–7), (800 ng/kg/min) A779, (10 mg/kg/day) PD123319.

15882 Rai, P., Lederman, R., Haque, S., Rehman, S., Kumar, V., Sataranatrajan, K., Malhotra, A., Kasinath, B. S., Singhal, P. C. Renin angiotensin system modulates mTOR pathway through AT2R in HIVAN. Exp Mol Pathol 2014; 96(-3-):431-7. >>> Telmisartan; PD123319; Doxycycline; aliskiren; Saline; water; SC; mice; 2004; Controls received mp w/ vehicle; animal info : Tg26 mice; FVBN mice, Tg26 mice; Vpr transgenic mice (4 week old); immunology; Dose: Telmisartan (AT1R blocker, 300Ǩg/day), PD123319 (AT2R blocker, 3Ǩg/day); Doxycycline + aliskiren (50 mg/kg).

15082 Shimada, K., Furukawa, H., Wada, K., Wei, Y., Tada, Y., Kuwabara, A., Shikata, F., Kanematsu, Y., Lawton, M.T., Kitazato, K.T., Nagahiro, S., Hashimoto, T., Hashimoto, T. Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2015; 35(--):1163-1168. >>> A779; angiotensin (1-7); PD123319; PBS; IP; Mice; 1002; Controls received mp w/ vehicle; animal info (male, WT or AT2RKO, 8-10 weeks old); cardiovascular; peptides; bp measured using tail cuff;.

14956 Hao, P.P., Yang, J.M., Zhang, M.X., Zhang, K., Chen, Y.G., Zhang, C., Zhang, Y., Zhang, Y. Angiotensin-(1-7) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2015; 308(--):H1007-H1019. >>> Angiotensin (1-7); perinodopril; A779; PD123319; NaCl; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 200g, STZ); cardiovascular; peptides; diabetes;.

14785 Zheng, H., Pu, S.Y., Fan, X.F., Li, X.S., Zhang, Y., Yuan, J., Zhang, Y.F., Yang, J.L., Yang, J.L. Treatment with angiotensin-(1-9) alleviates the cardiomyopathy in streptozotocin-induced diabetic rats. BIOCHEMICAL PHARMACOLOGY 2015; 95(--):38-45. >>> Angiotensin (1-9); PD123319; A779; Water, distilled; SC; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley STZ, 2 months old); cardiovascular; peptides; diabetes;.

14633 Dai, S.Y., Peng, W., Zhang, Y.P., Li, J.D., Shen, Y., Sun, X.F., Dai, S.Y. Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats. Journal of Neuroinflammation 2015; 12(--):U8-U18. >>> PD123,319; CSF/CNS; Rat; Control animisl received mp w/ vehicle; animal info (male, female, 10-12 wks old, Wistar); ALZET brain infusion kit used.

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33. Perindopril

14792 Qu, Z., Xu, H.X., Tian, Y.H., Tian, Y.H. Effects of angiotensin-converting enzyme inhibition and bradykinin peptides in rats with myocardial infarction. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2015; 8(--):3410-3417. >>> Perindopril; bradykinin; Saline; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wister, 8-12 weeks old, 200-250 g); cardiovascular; peptides;.

4639 Higaki, J., Aoki, M., Morishita, R, Kida, I, Taniyama, Y, Tomita, N., Yamamoto, K, Moriguchi, A., Kaneda, Y, Ogihara, T. In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy.. Arterioscler. Thromb. Vasc. Biol 2000; 20(--):428-434. >>> Perindopril;; Saline; PEG 400;; IP;; rat;; controls received mp w/vehicle; cardiovascular;.

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34. Pindolol

P4963 Haddjeri,N., Blier,P. Effects of sustained (+/-)pindolol administration on serotonin neurotransmission in rats. JOURNAL OF PSYCHIATRY&NEUROSCIENCE 2000; 25(--):378-388. >>> Pindolol; Saline; SC; rat; 2 weeks; controls received mp w/ vehicle; comparison of ip injections vs. mp;.

P4647 Haddjeri,N., Blier,P., de Montigny,C. Acute and long-term actions of the antidepressant drug mirtazapine on central 5-HT neurotransmission.. Journal of Affective Disorders 1998; 51(--):255-266. >>> Mirtazapine; Pindolol;; NaCl; Ascorbic acid;; SC;; rat;; 2, 21 days;; controls received mp w/ vehicle; comparison of IV injections vs mp; antidepressant; pindolol infused for 2 days; mirtazapine administered for 21 days..

P4052 Haddjeri,N., de Montigny,C., Curet,O., Blier,P. Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. Eur.J.Pharmacol. 1998; 343(--):179-192. >>> Befloxatone; Pindolol; Water; Ethanol; SC; rat; 2, 21 days; controls received mp w/vehicle; befloxatone is an antidepressant; agents infused separately or concomitantly; antihypertensive.

P1826 Nanoff,C., Stroher,M., Haschkowitz,H., Schutz,W., Pittner,H. Desensitization pattern of cardiac B-adrenoceptor subtypes by prolonged in vivo infusion of pindolol and celiprolol in rats. Basic Res.Cardiol. 1990; 85(--):88-95. >>> Celiprolol; Pindolol; Isoprenaline; Propranolol; HCl; Saline; SC; rat; 2001; 7 days; antihypertensive.

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35. Prazosin

15016 Disdier, C., Devoy, J., Cosnefroy, A., Chalansonnet, M., Herlin-Boime, N., Brun, E., Lund, A., Mabondzo, A., Mabondzo, A. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat. Particle and Fibre Toxicology 2015; 12(--):U1-U20. >>> Atenolol; digoxin; prazosin; PEG 200; DMSO; SC; Rat; 2001D; Animal info (male, Fisher F344, 8 weeks old, 180-250g); 50% PEG 200 used; 50% DMSO used;.

14404 Skelly, M.J., Weiner, J.L., Weiner, J.L. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. BRAIN AND BEHAVIOR 2014; 4(--):468-483. >>> Prazosin; propranolol; duloxetine; DMSO; saline, sterile; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Long Evans, adult, 300g); functionality of mp verified by residual volume; 10% DMSO used; stress/adverse reaction: (see pg. 472); post op. care (ketoprofen 3 mg/kg SC); behavioral testing (ethanol intake, open field test, locomotor activity, elevated plus maze); dependence;"Drug doses were calculated based on the estimated mean weight of animals in each group halfway through the drug delivery period (taking the mean weight at baselineand adding projected weight gain across 2 weeks)"pg 470; pumps removed after 4 weeks;.

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36. Propranolol

15188 Zhao, L., Xu, J.H., Liang, F., Li, A., Zhang, Y., Sun, J., Xu, J.H. Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. PLoS One 2015; 10(--):U1894-U1908. >>> Propranolol hydrochloride; ICI118,551; SC; Mice (nude); 1004; Animal info (male, BALB/C nu/nu, 4 weeks old); cancer (colon, HT-29);.

15011 Liu, J., Deng, G.H., Zhang, J., Wang, Y., Xia, X.Y., Luo, X.M., Deng, Y.T., He, S.S., Mao, Y.Y., Peng, X.C., Weil, Y.Q., Jiang, Y., Jiang, Y. The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models. PSYCHONEUROENDOCRINOLOGY 2015; 52(--):130-142. >>> Norepinephrine bitartrate hydrate; propranolol; Ascorbic acid; PBS; SC; Mice; 1004; Animal info (female, BALB/c, 5-7 weeks old); cancer (colorectal carcinoma, human);.

14996 Kline, R.H., Exposto, F.G., O'Buckley, S.C., Westlund, K.N., Nackley, A.G., Nackley, A.G. CATECHOL-O-METHYLTRANSFERASE INHIBITION ALTERS PAIN AND ANXIETY-RELATED VOLITIONAL BEHAVIORS THROUGH ACTIVATION OF beta-ADRENERGIC RECEPTORS IN THE RAT. NEUROSCIENCE 2015; 290(--):561-569. >>> Propranolol; OR486; DMSO; ethanol; saline; SC; Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 325-425g); behavioral testing (thermal place preference; light/dark preference; tactile allodynia); cardiovascular;"We attribute the overall differences in exploratory activity between the acute and chronic cohorts possibly due to the anxiety-provoking effects of repetitive i.p. injections in the acute but not the chronic cohort"pg 565;.

14404 Skelly, M.J., Weiner, J.L., Weiner, J.L. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. BRAIN AND BEHAVIOR 2014; 4(--):468-483. >>> Prazosin; propranolol; duloxetine; DMSO; saline, sterile; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Long Evans, adult, 300g); functionality of mp verified by residual volume; 10% DMSO used; stress/adverse reaction: (see pg. 472); post op. care (ketoprofen 3 mg/kg SC); behavioral testing (ethanol intake, open field test, locomotor activity, elevated plus maze); dependence;"Drug doses were calculated based on the estimated mean weight of animals in each group halfway through the drug delivery period (taking the mean weight at baselineand adding projected weight gain across 2 weeks)"pg 470; pumps removed after 4 weeks;.

14217 Herrera, J.A., Ward, C.S., Pitcher, M.R., Percy, A.K., Skinner, S., Kaufmann, W.E., Glaze, D.G., Wehrens, X.H.T., Neul, J.L., Neul, J.L. Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na(+)-channel-blocking antiepileptic drugs. Disease Models&Mechanisms 2015; 8(--):363-371. >>> Propranolol; NaCl; ascorbic acid; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (female, Mecp2 Null/+, 10 months old ); functionality of mp verified by serum levels; 2% ascorbic acid used; cardiovascular;.

13832 Kim-Fuchs, C., Le, C.P., Pimentel, M.A., Shackleford, D., Ferrari, D., Angst, E., Hollande, F., Sloan, E.K., Sloan, E.K. Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment. BRAIN BEHAVIOR AND IMMUNITY 2014; 40(--):40-47. >>> Propranolol, r/s-; isoproterenol, s/s-; Water; HCl; SC; Mice (nude); 1002; 1004; Controls received mp w/ vehicle; animal info (female, BALB/c Foxn1nu nude athymic, 6 weeks old); functionality of mp verified by drug plasma; pumps replaced every 14 days or 24 days; cancer (pancreatic); 1 mM HCl;.

13521 Maranon, R.O., Lima, R., Mathbout, M., do Carmo, J.M., Hall, J.E., Roman, R.J., Reckelhoff, J.F. Postmenopausal hypertension: role of the sympathetic nervous system in an animal model. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2014; 206(-4-):R248-R256. >>> Propranolol; SHU-9119; CSF/CNS; SC; Rat; Control animals received mp w/ vehicle; animal info (retired breeder, female, 4-9 mo old, 18-20 mo old, young female SHR).

13484 Deng, G.H., Liu, J., Zhang, J., Wang, Y., Peng, X.C., Wei, Y.Q., Jiang, Y. Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model. JOURNAL OF EXPERIMENTAL&CLINICAL CANCER RESEARCH 2014; 33(-;-):U1-U12. >>> Norepinephrine; propranolol; Ascorbic acid; saline; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (Female, C57BL6, 4-6 weeks old); cancer (melanoma; adenocarcinoma); immunology;"Seeing that microosmotic pumps (1004 type) are of the ability of pumping drugs contained incessantly for up to 4 weeks and exhibit reliable effects in mouse models, the pumps were taken into account in our research to deal with the short half life period of NE."pg 7; Primed pumps in 37C saline for 48 hours; Picture on pg 6 of pump and tumor on mouse..

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37. Ramipril

P6958 Dumoulin,M.J., Adam,A., Burnett,J., Heublein,D., Yamaguchi,N., Lamontagne,D. The cardioprotective effect of dual metallopeptidase inhibition: respective roles of endogenous kinins and natriuretic peptides. Canadian Journal of Physiology and Pharmacology 2005; 83(-2-):166-173. >>> Omapatrilat; ramipril; SC; Rat; 2ML2; 7 days; Enzyme inhibitor (ACE and Metallopeptidase); cardiovascular; ischemia (cardiac); "The present study demonstrates for the first time that a chronic treatment with a dual metallopeptidase inhibitor, namely omapatrilat, reduces the deleterious consequences of a global ischemia in isolated rat hearts." (p. 171).

P5674 Tschope,C., Seidl,U., Reinecke,A., Riester,U., Graf,K., Schultheiss,H.P., Hilgenfeldt,U., Unger,T. Kinins are involved in the antiproteinuric effect of angiotensin-converting enzyme inhibition in experimental diabetic nephropathy. INTERNATIONAL IMMUNOPHARMACOLOGY 2003; 3(-3-):335-344. >>> Hoe 140; Ramipril; SC; Rat; 2002; 14 days; Antihypertensive; Hoe 140 is a B2-receptor antagonist also called icatibant; agents infused together in same pump in some animals..

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38. Ramiprilat

3833 Fernandez-Alfonso, M.S., Martorana, P.A., Licka, I., van Even, P., Trobisch, D., Scholkens, B.A., Paul, M. Early induction of angiotensin I-converting enzyme in rat carotid artery after balloon injury. Hypertension 1997; 30(-pt 1-):272-277. >>> Ramiprilat; HR 720; DMSO; Water; SC; rat; 2ML2; 2ML4; 2ML2 pumps replaced after 14 days; antihypertensive; cardiovascular; some animals received multiple pumps per animal (2); ramiprilat is the active metabolite of ramipril; HR 720 is an angiotensin II receptor antagonist.

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39. Reserpine

10799 Ghia, J.E., Blennerhassett, P., Deng, Y.K., Verdu, E.F., Khan, W.I., Collins, S.M. Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression. Gastroenterology 2009; 136(-7-):2280-2288. >>> Reserpine; choline chloride; methyllycaconitine; Water; acetic acid; CSF/CNS; IP; Mice; Controls received mp w/ vehicle; animal info (male, C57BL/6, 7-9 wks old, alpha 7nAchR -/-); post op. care (buprenorphine); Plastics One cannula used with PE60 tubing.

8982 Ghia, J.E., Blennerhassett, P., Collins, S.M. Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression. Journal of Clinical Investigation 2008; 118(-6-):2209-2218. >>> Reserpine; Acetic acid; CSF/CNS; Mice; Controls received mp w/ vehicle; dose-response (Fig. 1); comparison of IP injection vs. mp; no stress (see pg. 2210); antihypertensive; cyanoacrylate adhesive; animal info (male, female, C57BL/6, op/op, wt, 7-9 wks old, colitis, vagotomy); animal model of depression; plastics one cannula used; PE-60 used.

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40. Rilmenidine

16014 Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T. P., Davern, P. J., Head, G. A. Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice. J Hypertens 2014; 32(-3-):575-86. >>> rilmenidine; Ringer’s solution; CSF/CNS (ventricles); mice; 1002; Controls received mp w/ ringer’s solution vehicle; animal info (BPH/2J and BPN/3J mice); functionality of mp verified by behavioral tests; dose-response (pg 577-582, description and graphical representation); behavioral testing (pg 577; mice were exposed to aversive behavioral stimuli; restraint stress and dirty cage-switch tests conducted); tissue perfusion (brain tissue); antihypertensive; antihypertensive; Dose: 15ug/hr of rilmenidine.

10075 Burke, S.L., Head, G.A. Cardiac and renal baroreflex control during stress in conscious renovascular hypertensive rabbits: effect of rilmenidine. Journal of Hypertension 2009; 27(-1-):132-141. >>> Rilmenidine; Saline; SC; Rabbit; 2ML4; Controls received mp w/ vehicle; comparison of IV injections vs. SC mp; antihypertensive; animal info (mixed breed, male, female, 2.4-3.2 kg.).

9276 Signolet, I.L., Bousquet, P.P., Monassier, L.J.P. Improvement of cardiac Diastolic function by long-term centrally mediated sympathetic inhibition in one-kidney, one-clip hypertensive rabbits. American Journal of Hypertension 2008; 21(-1-):54-60. >>> Rilmenidine; metoprolol; SC; Rabbit; 2ML2; Controls received mp w/ vehicle; animal info (New Zealand, White, 4-6 wks old, male, 0.7-0.9 kg., nephrectomized); long-term study.

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41. Tertatolol

3761 Tan, Y.Y., Summers, R.J. B-adrenoceptor regulation in rat heart, lung and skin after chronic treatment with (-)-tertatolol or (-)-propranolol. J. Auton. Pharmac 1995; 15(--):421-436. >>> Tertatolol; Propranolol; HCl; SC; rat; 2002; controls received mp w/ vehicle; antihypertensive; cardiovascular; beta-adrenoceptor antagonists; examined heart rate and systolic blood pressure.

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42. Valsartan

13911 Ramirez, T.A., Iyer, R.P., Ghasemi, O., Lopez, E.F., Levin, D.B., Zhang, J., Zamilpa, R., Chou, Y.M., Jin, Y.F., Lindsey, M.L., Lindsey, M.L. Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. Journal of Molecular and Cellular Cardiology 2014; 72(--):326-335. >>> Aliskiren; valsartan; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (MMP-9 null or WT); cardiovascular; bp measured using MC4000 bp analysis system;.

13518 Zeniya, M., Sohara, E., Kita, S., Iwamoto, T., Susa, K., Mori, T., Oi, K., Chiga, M., Takahashi, D., Yang, S.S., Lin, S.H., Rai, T., Sasaki, S., Uchida, S. Dietary Salt Intake Regulates WNK3-SPAK-NKCC1 Phosphorylation Cascade in Mouse Aorta Through Angiotensin II. Hypertension 2013; 62(-5-):872-878. >>> Valsartan; angiotensin II; aldosterone; IP; Mice; Animal info (C57BL/6J. male); peptides.

13221 Thomas, C.M., Yong, Q.C., Seqqat, R., Chandel, N., Feldman, D.L., Baker, K.M., Kumar, R. Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clinical Science 2013; 124(-7-8-):529-541. >>> Insulin; aliskiren (renin inhibitor); benazeprilat (ACEi); valsartan (ARB); streptozotocin; Saline; SC; Mice; 1004; Controls received mp w/vehicle, or (0.1M sodium citrate buffer (pH 4.5)); cardiovascular; animal info (male, C57b16/J, 12 weeks, blood glucose>250 mg/dl); pumps replaced every 4 weeks; enzyme inhibitor (renin); long-term study; diabetes;.

13169 Yong, Q.C., Thomas, C.M., Seqqat, R., Chandel, N., Baker, K.M., Kumar, R. Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovascular Diabetology 2013; 12(-;-):U1-U13. >>> Aliskiren; benazeprilat; valsartan; PD123319; Saline; SC; Mice; 1004; Cardiovascular; petides; animal info (12 wks old, male, AT-KO); functionality of mp verified by echocardiography; pumps replaced every 4 weeks; enzyme inhibitor (renin); long-term study;.

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What researchers are saying ...

"Utilizing continuous minipump administration enhances the knockdown to 63% of control." (p. 619) This compared with 40% by twice daily administration. "The results of the present study confirm the utility of osmotic minipump administration of antisense oligonucleotides." (p. 621) Falk et al., Pharmacol Biochem Behav 2002;72:617-622.