References on the Intra-Arterial Administration of Agents Using ALZET® Osmotic Pumps

16235 Rigassi, L., Barchiesi Bozzolo, F., Lucchinetti, E., Zaugg, M., Fingerle, J., Rosselli, M., Imthurn, B., Jackson, E. K., Dubey, R. K. 2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells. Am J Physiol Endocrinol Metab 2015; 309(-12-):E995-1007. >>> Estradiol, 2-methoxy; DMSO; IA (carotid artery); rat; Controls received mp w/ vehicle; animal info (male Wistar Kyoto rats, 350 to 400 g); dose-response (E999); 0.1% DMSO; cardiovascular; cardiovascular; Balloon injury-induced neointima formation; Dose (350 ug/kg/day);.

15957 Lei, X. F., Kim-Kaneyama, J. R., Arita-Okubo, S., Offermanns, S., Itabe, H., Miyazaki, T., Miyazaki, A. Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms. J Am Heart Assoc 2014; 3(-3-):e000747. >>> Angiotensin II; saline; IA (aorta); mice; 2004; Controls: tamoxifen-injected Apoe_/_ mice; mp w/ saline; Controls: tamoxifen-injected Apoe_/_ mice; mp w/ saline; cardiovascular, aorta; Dose: 1000ng/kg; Industry authored (American Heart Association);.

14454 Vries, M.H.M., Wagenaar, A., Verbruggen, S.E.L., Molin, D.G.M., Post, M.J., Post, M.J. CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. ANGIOGENESIS 2015; 18(--):163-171. >>> SB225002; CXCL1; IA (femoral); Rat; 2ML1; Controls received mp w/ PBS;.

13938 Zhao, Y., Xu, H., Yu, W.H., Xie, B.D., Xie, B.D. Complement anaphylatoxin C4a inhibits C5a-induced neointima formation following arterial injury. Molecular Medicine Reports 2014; 10(--):45-52. >>> C5a, recombinant; C4a, recombinant; PBS; BSA; IA (femoral); Mice; Animal info (C57BL6N, 16 week old); cardiovascular; immunology; arterial injury;.

13294 Matyal, R., Chu, L., Mahmood, F., Robich, M.P., Wang, A., Hess, P.E., Shahul, S., Pinto, D.S., Khabbaz, K., Sellke, F.W. Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia. Journal of Molecular and Cellular Cardiology 2012; 53(-6-):891-898. >>> Neuropeptide Y; Heparin; BSA; IA; Swine; 2ML4; Animal info (swine model of metabolic syndrome with chronic myocardial ischemia, six-week-old, male; Yorkshire miniswine); ischemia (arterial).

13269 Liu, X.B., Terry, T., Pan, S., Yang, Z.W., Willerson, J.T., Dixon, R.A.F., Liu, Q. Targeted Delivery of Carbaprostacyclin to Ischemic Hindlimbs Enhances Adaptive Remodeling of the Microvascular Network. Hypertension 2013; 61(-5-):1036-U290. >>> Carbaprostacyclin, cPGI2;; IA (femoral); Mice; Controls received mp w/vehicle, or saline; animal info (C57 black mice (C57BL/6J), 8-12 wks old, acute ischemia model); multiple pumps per animal (2); two pumps with saline or cPGI2 for 24 hours); PE50 catheter.

12441 Zhou, J., Lee, P.L., Tsai, C.S., Lee, C.I., Yang, T.L., Chuang, H.S., Lin, W.W., Lin, T.E., Lim, S.H., Wei, S.Y., Chen, Y.L., Chien, S., Chiu, J.J. Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012; 109(-20-):7770-7775. >>> Noggin; IA (abdominal aorta); Mice; Controls received mp w/ saline; animal info (ApoE -/-, C57BL/6).

12333 De Meyer, I., Martinet, W., Schrijvers, D.M., Timmermans, J.P., Bult, H., De Meyer, G.R.Y. Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques. Basic Research In Cardiology 2012; 107(-3-):U36-U48. >>> Dexamethasone; imiquimod; IA (carotid); Rabbit; 2ML1; Animal info (male, New Zeland, white, 2.5-4.0 kg); one group contained mixture of dexamethasone and imiquimod.

12012 Frontini, M.J., Nong, Z.X., Gros, R., Drangova, M., O'Neil, C., Rahman, M.N., Akawi, O., Yin, H., Ellis, C.G., Pickering, J.G. Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells. NATURE BIOTECHNOLOGY 2011; 29(-5-):421-U232. >>> Fibroblast growth factor-9; PBS; IA (femoral); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 9-10 mo old); polyethylene tubing used; ischemia (hind limb).

11817 Damon, D.H., TeRiele, J.A., Marko, S.B. Eph/ephrin interactions modulate vascular sympathetic innervation. Autonomic Neuroscience-Basic&Clinical 2010; 158(-1-2-):65-70. >>> Ephrin-A4-Fc, ligand; PBS; Evans blue; IA (femoral); Rat; 1002; Controls received mp w/ IgG-Fc; animal info (adult, male, 250-300 g, adult, post partum, females, neonatal, Sprague-Dawley).

11717 Chan, M.C., Weisman, A.S., Kang, H., Nguyen, P.H., Hickman, T., Mecker, S.V., Hill, N.S., Lagna, G., Hata, A. The Amiloride Derivative Phenamil Attenuates Pulmonary Vascular Remodeling by Activating NFAT and the Bone Morphogenetic Protein Signaling Pathway. MOLECULAR AND CELLULAR BIOLOGY 2011; 31(-3-):517-530. >>> Phenamil; Saline; DMSO; IA (carotid); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 6-7 wks old, 250-300 g); 50% DMSO used; hypobaric hypoxia; phenamil is an amiloride analog.

11637 Troidl, K., Tribulova, S., Cai, W.J., Rueding, I., Apfelbeck, H., Schierling, W., Troidl, C., Schmitz-Rixen, T., Schaper, W. Effects of Endogenous Nitric Oxide and of DETA NONOate in Arteriogenesis. Journal of Cardiovascular Pharmacology 2010; 55(-2-):153-160. >>> Diethylenetriamine NONOate; Alkaline solution; IA; Rabbit; Animal info (white, New Zealand);"DETA NONOate in alkaline solution (pH 8) is stable but releases NO when in contact with blood during a continuous infusion from an implanted osmotic minipump connected to a catheter indwelling the proximal or distal stump of the occluded artery."pg 159.

11590 Schierling, W., Troidi, K., Apfelbeck, H., Troidl, C., Kasprzak, P.M., Schaper, W., Schmitz-Rixen, T. Cerebral Arteriogenesis is Enhanced by Pharmacological as Well as Fluid-Shear-Stress Activation of the Trpv4 Calcium Channel. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 2011; 41(-5-):589-596. >>> PDD, 4 alpha; IA (carotid); Rat; 2001; Animal info (male, Sprague Dawley, 250-300 g); post op. care (buprenorphine); figure 4a, schematic diagram of the osmotic pump.

10438 Troidl, C., Nef, H., Voss, S., Schilp, A., Kostin, S., Troidl, K., Szardien, S., Rolf, A., Schmitz-Rixen, T., Schaper, W., Hamm, C.W., Elsaesser, A., Moellmann, H. Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model. Journal of Molecular and Cellular Cardiology 2010; 49(-1-):142-151. >>> Phorbol didecanoate, 4-alpha-; IA (femoral); Pig; 2ML1; Controls received mp w/ saline or sham operation; cardiovascular; animal info (male, juvenile, crossbred, 38kg, femoral artery occlusion); post op. care (cefquinome, fentanyl); ischemia (hind limb); excellent color photograph of multiple mp placement (Fig. 1); multiple pumps per animal (2).


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What researchers are saying...

“...opioid and nonopioid analgesics were continuously infused from subcutaneously implanted osmotic mini-pumps, a convenient modality of drug delivery that allows for drug delivery at constant rate for prolonged periods of time without experimenter intervention.” Bruins Slot et al., Pharmacology, Biochemistry and Behavior 2002;72:943-951.