References on the Intra-Arterial Administration of Agents Using ALZET^® Osmotic Pumps

P8836 Nichols,T.C., Busby,WH Jr, Merricks,E., Sipos,J., Rowland,M., Sitko,K., Clemmons,D.R. Protease-resistant insulin-like growth factor (IGF)-Binding protein-4 inhibits IGF-I actions and neointimal expansion in a porcine model of neointimal hyperplasia. Endocrinology 2007; 148(-10-):5002-5010. >>> Insulin-like growth factor-binding protein-4; Insulin-like growth factor-binding protein-4, mutated; Insulin-like growth factor I, recomb. human; PBS; IA (carotid); IA (femoral); Pig; 21 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, female, spotted Poland/China, 12 months old); protease resistant mutant form of IGFBP-4.

P8728 Gradl,G., Finke,B., Schattner,S., Gierer,P., Mittlmeier,T., Vollmar,B. Continuous intra-arterial application of substance P induces signs and symptoms of experimental complex regional pain syndrome (CRPS) such as edema, inflammation and mechanical pain but no thermal pain. Neuroscience 2007; 148(-3-):757-765. >>> Substance P; Saline; heparin; IA (femoral); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; good methods (p. 758); animal info (male, Sprague-Dawley, 225-250g); pain.

P8461 Chan,E.C., Datla,S.R., Dilley,R., Hickey,H., Drummond,G.R., Dusting,G.J. Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits. Cardiovascular Research 2007; 75(-4-):710-718. >>> Apocynin; DMSO; IA (carotid); Rabbit; 2001; ; Controls received mp w/vehicle, or no treatment; enzyme inhibitor (NADPH oxidase); cardiovascular; animal info (male, New Zealand White, 3-4kg); 0.1% DMSO; mp attached to catheter to hollow, nonoclusive silastic collar around common cartoid artery.

P8353 Croons,V., Martinet,W., Herman,A.G., Timmermans,J.P., De Meyer,G.R.Y. Selective clearance of macrophages in atherosclerotic plaques by the protein synthesis inhibitor cycloheximide. Journal of Pharmacology and Experimental Therapeutics 2007; 320(-3-):986-993. >>> Cycloheximide; IA (carotid); Rabbit; 2ML1; 3 days; Controls received mp w/ saline; cardiovascular; animal info (male, New Zealand white, 3.1-3.8 kg); mp connected to a collar around artherosclerotic carotid arteries.

P8306 Tiranathanagul,K., Dhawan,V., Lytle,I.F., Zhang,W., Borschel,G.H., Buffington,D.A., Tziampazis,E., Brown,D.L., Humes,H.D. Tissue engineering of an implantable bioartificial hemofilter. ASAIO Journal 2007; 53(-2-):176-186. >>> Platelet-derived growth factor-BB; vascular endothelial growth factor 164; Saline, normal; albumin, rat serum; acetic acid; IA (femoral); IV (femoral); Rat; 2004; 28 days; Artificial kidney; controls received mp w/ vehicle; peptides; animal info (male, Fisher 344); mp attached by cannula to bioartificial hemofilter device, which surrounded and delivered agent to the femoral vessels; nephrology.

P8299 Cruze,C.A., Su,F., Limberg,B.J., Deutsch,A.J., Stoffolano,P.J., Dai,H.J., Buchanan,D.D., Yang,H.T., Terjung,R.L., Spruell,R.D., Mittelstadt,S.W., Rosenbaum,J.S. The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency. Peptides 2007; 28(-2-):269-280. >>> Peptide YY, recomb. human; peptide YY (3-36), recomb. human; vascular endothelial growth factor 165; PBS; glycerol; sodium citrate; Tween 20; IA (iliac); Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (femoral artery occlusion); dose-response (fig. 4); half-lfie (p. 276)<30 minutes; cardiovascular; peptides; ischemia (hindlimb); animal info (male, Sprague-Dawley, 325-350 grams).

P7731 Carr,A.N., Howard,B.W., Yang,H.T., Eby-Wilkens,E., Loos,P., Varbanov,A., Qu,A., DeMuth,J.P., Davis,M.G., Proia,A., Terjung,R.L., Peters,K.G. Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: Support for an endothelium-dependent mechanism. Cardiovascular Research 2006; 69(-4-):925-935. >>> Vascular endothelial growth factor; stromal cell-derived factor-1a; PBS; glycerol; sodium acetate; sodium azide; IA (iliac); Rat; 2 weeks; Controls received mp w/ vehicle; dose-response (table 1); cardiovascular; peptides; animal info (adult); bilateral femoral artery ligation; occlusive cardiovascular disease.

P7647 Barber,M.N., Gaspari,T.A., Kairuz,E.M., Dusting,G.J., Woods,R.L. Atrial natriuretic peptide preserves endothelial function during intimal hyperplasia. JOURNAL OF VASCULAR RESEARCH 2005; 42(-2-):101-110. >>> Atrial natriuretic peptide; C-type natriuretic peptide; Saline, sterile; IA (carotid); perivascular (arterial collar); Rabbit; 2001; 7 days; Cardiovascular; animal info (New Zealand white, 3-4 kg).

P7576 Zhao,L.R., Spellman,S., Kim,J., Duan,W.M., McCarthy,J.B., Low,W.C. Synthetic fibronectin peptide exerts neuroprotective effects on transient focal brain ischemia in rats. Brain Research 2005; 1054(-1-):1-8. >>> Fibronectin-derived peptide, synthetic; PBS; IA (carotid); Rat; 24 hours; Controls received mp w/ vehicle or control peptide PRARI; peptides; ischemia (cerebral); animal info (male, Sprague-Dawley, 300-350 g); peptide: PRARIY; MCAO.

P7495 Burchardt,M., Burchardt,T., Anastasiadis,A.G., Buttyan,R., de la Taille,A., Shabsigh,A., Frank,J., Shabsigh,R. Application of angiogenic factors for therapy of erectile dysfunction: protein and DNA transfer of VEGF 165 into the rat penis. UROLOGY 2005; 66(-3-):665-670. >>> Vascular endothelial growth factor, human 165; Saline, sterile; heparin; IA (renal); Rat; 2004; 28 days; Controls received mp w/ vehicle; functionality of mp verified by VEGF serum immunoassay; comparison of CDNA plasmid micro-injections vs. mp; gene therapy; peptides; animal info (male, Sprague-Dawley); urology; 2000 Units of heparin used.

P6784 Schirmer,S.H., Buschmann,I.R., Jost,M.M., Hoefer,I.E., Grundmann,S., Andert,J.P., Ulusans,S., Bode,C., Piek,J.J., van Royen,N. Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis. Cardiovascular Research 2004; 64(-2-):356-364. >>> Monocyte chemoattractant protein-1, recomb. human; leptin, recomb. human; IA (femoral); Rabbit; 2ML1; 7 days; Controls received mp w/ PBS; no stress (see pg. 359); cardiovascular; peptides; right femoral artery occlusion.

P6436 Porro,C.A., Cavazzuti,M., Giuliani,D., Vellani,V., Lui,F., Baraldi,P. Effects of ketamine anesthesia on central nociceptive processing in the rat: A 2-deoxyglucose study. Neuroscience 2004; 125(-2-):485-494. >>> Heparin; Saline; IA (carotid); IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; post op. care (wounds treated with local anesthetics, lidocaine cream); PE-50 tubing was filled with rat serum and heparin and plugged with nylon fishing line until the pumps were attached; pumps were used only as a means of keeping vessel catheters patent..

P6394 Sudoh,M., Kishimoto,Y., Marumoto,B., Inoue,M., Sano,A., Miura,N., Horie,Y., Hasegawa,J., Ryoke,K. A new animal model of continuous catheterization for investigating mechanisms of arteritis associated with chemotherapy. LIFE SCIENCES 2004; 74(-24-):3025-3032. >>> Fluorouracil, 5-FU; peplomycin; Saline, heparinized; IA (abdominal aorta); Rat; 2ML1; 7 days; Controls received mp w/ vehicle; cancer; chemotherapeutic agents; PE-10 and 60 used; tubing attached using a moment binding agent (alon-alfa); catheter schematic p. 3027; pump placed IP.

P6370 Manoonkitiwongsa,P.S., Schultz,R.L., McCreery,D.B., Whitter,E.F., Lyden,P.D. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis. Journal of Cerebral Blood Flow and Metabolism 2004; 24(-6-):693-702. >>> Vascular endothelial growth factor; Saline; IA (carotid); Rat; 2001; 7 days; Controls received mp w/ vehicle; dose response (p. 697); stroke; ischemia (cerebral); biocompatible glue was used to secure catheter in artery.

P7695 van,Royen N., Hoefer,I., Bottinger,M., Hua,J., Grundmann,S., Voskuil,M., Bode,C., Schaper,W., Buschmann,I., Piek,J.J. Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression. Circ.Res. 2003/2/7; 92(-2-):218-225. >>> Monocyte chemotactic protein-1; IA (femoral); Mice; 1007D; 7 days; Controls received mp w/ PBS; cardiovascular.

P6621 Prior,B.M., Lloyd,P.G., Ren,J., Li,Z., Yang,H.T., Laughlin,M.H., Terjung,R.L. Arteriogenesis: Role of nitric oxide. ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH 2003; 10(-4-5-):207-216. >>> Fibroblast growth factor; heparinase I; IA (iliac); 2 weeks; Dose-response (p. 213); the heparinase I infusion group targeted the contralateral iliac vessel; pump or animal model not mentioned.

P6616 Ziegelhoeffer,T., Scholz,D., Friedrich,C., Helisch,A., Wagner,S., Fernandez,B., Schaper,W. Inhibition of collateral artery growth by mibefradil: Possible role of volume-regulated chloride channels. ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH 2003; 10(-4-5-):237-246. >>> Mibefradil; PBS; IA (femoral); Mice; 1007D; 7 days; Controls received mp w/ vehicle; antihypertensive; mibefradil is a tetralol calcium channel blocking agent; PE-50 heat stretched to an O.D of 0.22 mm.

P6123 Cao,R.H., Brakenhielm,E., Pawliuk,R., Wariaro,D., Post,M.J., Wahlberg,E., Leboulch,P., Cao,Y.H. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nature Medicine 2003; 9(-5-):604-613. >>> Fibroblast growth factor; platelet-derived growth factor; IA (femoral); Rabbit; 7 days; ischemia (hind-limb).

P6033 Boengler,K., Pipp,F., Fernandez,B., Ziegelhoeffer,T., Schaper,W., Deindl,E. Arteriogenesis is associated with an induction of the cardiac ankyrin repeat protein (carp). Cardiovascular Research 2003; 59(-3-):573-581. >>> Monocyte chemoattractant protein-1; doxorubicin; transforming growth factor-B1; IA (femoral); Rabbit; 2ML1; 24 hours; Cardiovascular.

P6009 Srivastava,S., Terjung,R.L., Yang,H.T. Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 2003; 285(-3-):H1190-H1197. >>> Fibroblast growth factor, basic; Sodium citrate; glycerol; PBS; IA (iliac); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume p. H1192; antihypertensive; post op. care (topical antibiotic powder); "The pump was housed in a tunnel under the skin in the left groin area; this placement did not hamper hindlimb movement while rats were walking on the treadmill." p. H1191; behavioral study; "There were no signs of ischemia or necrosis and no presence of infection or complications from the osmotic pumps..." p. H1192.

P5864 van Royen,N., Hoefer,I., Buschmann,I., Kostin,S., Voskuil,M., Bode,C., Schaper,W., Piek,J.J. Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits. Cardiovascular Research 2003; 57(-1-):178-185. >>> Monocyte chemoattractant protein-1; PBS; IA (femoral); Rabbit; 2ML1; 1 week; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (p. 181, 183); cardiovascular; peptides; MCP-1.

P5787 Deindl,E., Hoefer,I.E., Fernandez,B., Barancik,M., Heil,M., Strniskova,M., Schaper,W. Involvement of the fibroblast growth factor system in adaptive and chemokine-induced arteriogenesis. Circulation Research 2003; 92(-5-):561-568. >>> Polyanetholesulfonic Acid; Monocyte chemoattractant protein-1; IA (femoral); Rabbit; 1 week; Controls received mp w/ PBS; cardiovascular; MCP-1.

P5730 Buckwalter,J.B., Curtis,V.C., Valic,Z., Ruble,S.B., Clifford,P.S. Endogenous vascular remodeling in ischemic skeletal muscle: a role for nitric oxide. Journal of Applied Physiology 2003; 94(-3-):935-940. >>> L-NAME; D-NAME; Phenylephrine; Saline; heparin; IA (femoral); Rabbit; 2ML2; 6 weeks; Controls received mp w/ phenylephrine or D-NAME; enzyme inhibitor (Nitric oxide synthase); cardiovascular; peptides; L-NAME&D-NAME (no synthase inhibitors) were dissolved in heparinized saline (100 U/ml).

P5729 Boengler,K., Pipp,F., Fernandez,B., Richter,A., Schaper,W., Deindl,E. The ankyrin repeat containing SOCS box protein 5: a novel protein associated with arteriogenesis. Biochemical and Biophysical Research Communications 2003; 302(-1-):17-22. >>> Monocyte chemoattractant protein-1; Transforming Growth Factor-B; Doxorubicin; IA (femoral); Rabbit; 2ML1; 24 hours; Cardiovascular; peptides; MCP-1 is monocyte chemoattractant protein 1.

P5722 Arras,M., Ito,W.D., Scholz,D., Winkler,B., Schaper,J., Schaper,W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin.Invest 2003; 101(-1-):40-50. >>> Uridine, bromodeoxy-; IA (carotid); Rabbit; 2ML2; 3,7 days; Study proliferation of collateral arteries and capillaries.

P5682 Heeschen,C., Weis,M., Cooke,J.P. Nicotine promotes arteriogenesis. Journal of the American College of Cardiology 2003; 41(-3-):489-496. >>> Nicotine; fibroblast growth factor, basic; PBS; IA (iliac); Rabbit; 2ML2; 18 days; Controls received mp w/ vehicle..

P5645 Pipp,F., Heil,M., Issbrucker,K., Ziegelhoeffer,T., Martin,S., van den Heuvel,J., Weich,H., Fernandez,B., Golomb,G., Carmeliet,P., Schaper,W., Clauss,M. VEGFR-1-selective VEGF homologue PlGF is arteriogenic - Evidence for a monocyte-mediated mechanism. Circulation Research 2003; 92(-4-):378-385. >>> Vascular endothelial growth factor; Vascular endothelial growth factor-E; Monocyte chemoattractant protein-1; Placental growth factor; Phosphate buffer; albumin; IA (femoral); Mice; rabbit; 1 week; Controls received mp w/ vehicle; dose-response (p.381); peptides; placenta growth factor (PlGF) is a VEGF homologue; VEGF-E is a chimera containing the heparin-binding domain of VEGF; MCP-1.

P6224 Seye,C.I., Kong,Q.M., Erb,L., Garrad,R.C., Krugh,B., Wang,M.F., Turner,J.T., Sturek,M., Gonzalez,F.A., Weisman,G.A. Functional P2Y2 nucleotide receptors mediate uridine 5 '-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries. Circulation 2002; 106(-21-):2720-2726. >>> Uridine 5-triphosphate; IA (carotid); Rabbit; 2ML2; 3,14 days; Controls received mp w/ PBS; cardiovascular; post op. care (buprenorphine).

P5340 Scholz,D., Ziegelhoeffer,T., Helisch,A., Wagner,S., Friedrich,C., Podzuweit,T., Schaper,W. Contribution of arteriogenesis and angiogenesis to postocclusive Hindlimb perfusion in mice. Journal of Molecular and Cellular Cardiology 2002; 34(-7-):775-787. >>> Fibroblast growth factor 2; PBS; IA (femoral); Mice; 1007D; ; Controls received mp w/ vehicle; peptides.

P4988 Madsen,K.M., Neerhof,M.G., Wessale,J.L., Thaete,L.G. Influence of ETB receptor antagonism on pregnancy outcome in rats. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 2001; 8(--):239-244. >>> A-192621; Ethanol; Propyene glycol; Sodium hydroxide; IA (carotid); rat (pregnant); 7 days; controls received mp w/ vehicle; functionality of mp verified by plasma A-192621 levels; dose-response (fig 3. p. 242); peptides; A-192621 is an Endothelin-B receptor antagonist which blocks vasoconstriction; vehicle was 20% ethanol, 40% propylene glycol, 0.4 M sodium hydroxide..

P4782 Yang,H.T., Yan,Z., Abraham,J.A., Terjung,R.L. VEGF121- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production.. American Journal of Physiology-Heart and Circulatory Physiology 2001; 280(--):H1097-H1104. >>> Vascular endothelial growth factor 121; Fibroblast growth factor, basic;; PBS; Sodium citrate; Glycerol;; IA (femoral);; rat;; 2002;; 14 days;; Controls received mp w/ vehicle; cardiovascular; peptides; vehicle was PBS w/ 10% sodium citrate and 1.6% glycerol; sodium citrate used to prevent coagulation; glycerol used to enhance protein stability;.

P4491 Yang,H.T, Feng,Y. bFGF increases collateral blood flow in aged rats with femoral artery ligation.. Am.J.Physiol.(Heart Circ.Physiol) 2000; 278(--):H85-H93. >>> Fibroblast growth factor, basic;; Sodium citrate; Glycerol; PBS;; IA (iliac);; rat;; 2002;; 14 days;; controls received mp w/ vehicle; dose response; peptides, cardiovascular; recomb. human FGF used; sodium citrate used to maintain catheter patency; glycerol used to stabilize protein..

P4461 Yang,H.T, Ogilvie,R.W, Terjung,R.L  Am.J.Physiol.(Heart Circ.Physiol.43) 1998; 274(--):H2053-H2061. >>> Fibroblast growth factor, basic;; PBS; Sodium azide; Glycerol; Heparin;; IA (iliac);; rat;; 2002;; 2 weeks;; controls received mp w/vehicle; functionality of mp verified by residual volume; peptides; human. recomb fibroblast growth factor used;.

P4128 Hopkins,S.P., Bulgrin,J.P., Sims,R.L., Bowman,B., Donovan,D.L., Schmidt,S.P. Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia. J.Vasc.Surg. 1998; 27(-5-):886-895. >>> Vascular endothelial growth factor; Nitroglycerin; Saline; Heparin; IA (iliac); rabbit; 2ML4; 28 days; pump diagram (p. 888); 22 g intravenous catheter was inserted into tygon tubing; "implantable osmotic pumps offer an alternative simple delivery method, providing a constant release of soluble agents in a steady-state fashion." (p. 892); controls received mp w/vehicle; good methods (pp. 887-888); cardiovascular; peptides; ischemia.

P4004 Garin,E.H., Laflam,P., Chandler,L. Anti-interleukin 8 antibody abolishes effects of lipoid nephrosis cytokine. Pediatric Nephrology 1998; 12(--):381-385. >>> Cell culture supernatant factor; Antibody, anti-human interleukin 8; PBS, sterile; Albumin, bovine serum; IA (renal); rat; 2ML1; 5 days; controls received mp w/vehicle; functionality of mp verified by residual volume; heat-stretched PE-10 tubing used; immunology.

P4637 Matthys,K.E., Van Hove,C.E., Kockx,M.M, Andries,L.J., Osselaer,N.V, Herman,A.G., Bult,H  Arterioscler.Thromb.Vasc.Biol. 1997; 17(--):2423-2429. >>> Lipoprotein, low density-; lipoprotein, oxidized low density-;; PBS;; IA (carotid); rabbit; 14 days; controls received mp w/vehicle; pumps connected to silicone collars around carotid arteries; human LDL used..

P3975 Cha,M.C., Rojhani,A. Zinc deficiency inhibits the direct growth effect of growth hormone on the tibia of hypophysectomized rats. Biol.Trace.Elem.Res. 1997; 59(--):99-111. >>> Growth hormone, recomb. human; IA (femoral); rat; 2002; 13 days; controls received mp w/vehicle; replacement therapy (hypophysectomy); no stress (see pg. 103); stress/adverse reaction (p. 103); PE10, PE50 and PE60 tubing used; PE10 tubing was stretched to fit into the vessel; peptides;.

P3740 Chen,C., Hanson,S.R., Keefer,L.K., Saavedra,J.E., Davies,K.M., Hutsell,T.C., Hughes,J.D., Ku,D.N., Lumsden,A.B. Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation in the endarterectomized canine artery. J.Surg.Res. 1997; 67(--):26-32. >>> Proline, l-; Proline, nitric oxide-; NaOH; IA (femoral); dog; 2ML2; 7 days; controls received mp w/ proline to contralateral vessel; stability verified by in vitro assay; half-life (pg. 27); cardiovascular; constructed local infusion device and attached to mp via catheter.

P3730 Garin,E.H., West,L., Zheng,W. Effect of interleukin-8 on glomerular sulfated compounds and albuminuria. Pediatric Nephrology 1997; 11(--):274-279. >>> Interleukin-8; BSA; IA (renal); rat; 2ML1; 5 days; controls received mp w/BSA; good methods (pg. 275); peptides; used PE-10 catheter stretched to further reduce its diameter.

P3729 Ito,W.D., Arras,M., Winkler,B., Scholz,D., Schaper,J., Schaper,W. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ.Res. 1997; 80(--):829-837. >>> Uridine, bromodeoxy-; Monocyte chemoattractant protein-1; PBS; IA (femoral); Rabbit; 2ML2; no duration posted; controls received mp w/ PBS; functionality of mp verified by BrdU staining and residual volume; peptides; cardiovascular; MCP-1.

P4428 Mattar,S.G, Hanson,S.R,Pierce G.F,Chen,C, Hughes,J.D, Cook,J,E, Shen,C, Noe,B.A, Suwyn,C.R, Scott,J.R, Lumsden,A.B  Journal of Surgical Research 1996; 60(--):339-344. >>> Fibroblast growth factor; saporin;; Sodium citrate; NaCl; EDTA;; IA (carotid);; dog;; 2002;; 14 days;; controls received mp w/vehicle; stability verified for 14 days by cellular assay; peptides; Saporin- FGF2 conjugate was infused; pump placed externally; Saporin is a potent ribosome-inactivating protein..

P4413 Yang,H.T, Deschenes,M.R, Ogilvie,R.W, Terjung,R.L  Circulation Research 1996/7; 79(-1-):62-69. >>> Fibroblast Growth Factor, basic; Heparin;; Saline; Glycerol; Sodium azide;; IA (Femoral);; rat;; 2002;; 1,2,4 weeks;; controls received mp w/ heparin; functionality of mp verified by residual volume; long-term study, pumps replaced at day 14; no stress (p. 63); good methods (p.63); peptides; cardiovascular;.

P3530 Cardona-Sanclemente,L.E., Born,G.V.R. Increase by adrenaline or angiotensin II of the accumulation of low density lipoprotein and fibrinogen by aortic walls in unrestrained conscious rats. Br.J.Pharmacol. 1996; 117(--):1089-1094. >>> Epinephrine; Angiotensin II; Ascorbic acid; SC; IA (carotid); rat; 2ML4; 1007D; 6 days; controls received saline infusion; functionality of mp verified by plasma levels; stability verified by analyzing residual solution.

P4100 Hirko,M.K., Lin,P.H., Gosselin,C., Ren,D., Greisler,H.P. In vivo tissue distribution of fibroblast growth factor-1 after intraarterial delivery. ASAIO Journal 1995; 41(--):M630-M633. >>> Fibroblast growth factor; Heparin; 125I tracer; Radio-isotopes; IA (carotid); rabbit; 2001D; 24 hours; functionality of mp verified by residual radioactivity analysis; no stress (see pg. M631); good methods (p. M631); peptides; tissue distribution.

P4096 Levy,A.E., Alexander,J.W. Administration of intragraft interleukin-4 prolongs cardiac allograft survival in rats treated with donor-specific transfusion/cyclosporine. Transplantation 1995; 60(-5-):405-406. >>> Interleukin-4; Interleukin-10; IA (brachiocephalic); rat; 14 days; immunology; peptides; pump infused the brachiocephalic artery of a harvested heart, which was then implanted into a recipient; recomb. mouse IL-4&IL-10 used.

P3404 Yoshimura,N., Lee,C.J., Shiho,O., Kita,M., Imanishi,J., Oka,T. Local immunosuppressive therapy with monoclonal anti-T-cell antibody on renal allograft survival in the rat. II. Phenotypic and functional assessment of spleen cells. Transplant.Proc. 1995; 27(-1-):390-391. >>> Antibody, monoclonal, OX-19; Saline; IA (renal); IV (femoral); rat; 7 days; immunology; arterial infusion proved more effective than venous infusion.

P3381 Kirkham,T.C., Gibbs,J., Smith,G.P., Geary,N. Meal pattern analysis in rats reveals partial agonist activity of the bombesin receptor antagonist BW2258U89. Pharmacol.Biochem.Behav. 1995; 52(-1-):101-106. >>> BW2258U89; Saline; IA (celiac); rat; 2001; 6 days; controls received laporotomy&subsequent anesthesia; catheter tips passed through gauze before placement in arteries; catheters were anchored w/polypropylene microsuture; gauze was sutured to arterial wall.

P3296 Garin,E.H  Pediatric Nephrology 1995; 9(--):587-593. >>> Cell cultures, supernatant fraction of PBM; IA (renal); rat; 2ML1; 5 days; controls received mp w/ BSA in Hank's solution; idiopathic minimal lesion nephrotic syndrome; patient mononuclear cells used; pumps sutured to abdominal wall; "...chronic infusion allowed us to avoid the sudden increase in intravascular volume observed during the acute infusion studies..." (p.590).

P2617 Baskin,D.S., Browning,J.L., Widmayer,M.A., Zhu,Z.-Q., Grossman,R.G. Development of a model for Parkinson's disease in sheep using unilateral intracarotid injection of MPTP via slow continuous infusion. Life Sci. 1994; 54(-7-):471-479. >>> MPTP HCl; IA (carotid); sheep; 2ML1; 1-7 weeks; Neurodegenerative (Parkinson's disease); comparison of acute injections vs. mp; no stress (see pg. 474); catheter placed in proximal occipital artery (w/ distal end of artery occluded); ". . .slow continuous infusion may be a useful alternative to repeated dosing in animal studies using MPTP. . .".

P2982 Ferraresso,M., Rigotti,P., Stepkowski,S.M., Chou,T.-C., Kahan,B.D. Immunosuppressive effects of defibrotide. Transplantation 1993; 56(-4-):928-933. >>> Defibrotide; Cyclosporin A; PBS; Cremophor; IA (innominate); IV (lumbar); rat; 2002; 2ML1; no duration posted; Controls were untreated; comparison of ip injections or oral gavage vs. mp; defibrotide infused into artery of graft or recipient vein; defibrotide is an immunosuppressant w/ antithrombotic and profibrinolytic activities.

P2526 Alarid,E.T., Chen,P., Schaudies,R.P., Nicoll,C.S. Differential effects of an antiserum to epidermal growth factor on the development of transplanted rat embryos and fetal structures in vivo. Growth Factors 1993; 8(--):235-243. >>> Antibody, anti-epidermal growth factor; Epidermal growth factor; Water; Glycerol; Sodium nitrate; Heparin; Albumin; IA (renal); rat; 2002; 14 days; tissue perfusion (fetal tissue transplants); peptides.

P2525 Moses,B.L., Chan,D.W., Hruban,R.H., Forastiere,A., Richtsmeier,W.J. Comparison of intra-arterial and intravenous infusion of cisplatin for head and neck squamous cell carcinoma in a modified rat model. Arch Otolaryngol.Head Neck Surg. 1993; 119(--):612-617. >>> Cisplatin; IV (saphenous); IA (saphenous); rat (nude); 2ML1; 6 days; tissue perfusion (tumor xenograft); cancer.

P2511 Lee,C.J., Yoshimura,N., Shiho,O., Kita,M., Oka,T. Local immunosuppressive therapy with monoclonal anti-T cell antibody on renal allograft survival in the rat. Clin Exp Immunol 1993; 91(--):362-367. >>> Antibody, monoclonal; Saline; IA (renal); IV (femoral); rat; 2ML1; 7 days; tissue perfusion (kidney allograft); dose-response (table, p.364); immunology; comparison of single IV bolus, systemic IV infusion, or regional IA infusion.

P2220 Chiang,M.H., Kelley,K.M., Nicoll,C.S. Human placental lactogen directly inhibits rat cartilage growth processes in vivo and in vitro. Acta Endocrinol. 1993; 128(--):65-68. >>> Human placental lactogen; IA (iliac); rat; 2001; 7 days; controls received mp w/vehicle; stability verified in vitro for 6 days; peptides.

P2154 Matejka,G.L., Jennische,E. Local infusion of IGF-I into the kidney of pituitary intact rats induces renal growth. Acta Physiol.Scand. 1992; 145(--):7-18. >>> Insulin-like growth factor I; Albumin, bovine serum; Saline; IA (suprarenal); rat; 2ML1; 7 days; controls received mp with vehicle; tissue perfusion (kidney); dose-response; peptides; pumps infused into the artery and directly into renal parenchyma via a catheter sealed at the end and punctured along the sides; recomb. human IGF-1 used.

P2099 Alarid,E.T., Schlechter,N.L., Russell,S.M., Nicoll,C.S. Evidence suggesting that insulin-like growth factor-I is necessary for the trophic effect of insulin on cartilage growth in vivo. Endocrinology 1992; 139(-4-):2305-2309. >>> Antibody, anti-IGF I; Insulin; 125I tracer; Heparin; Radio-isotopes; Serum, rabbit; IA (iliac); rat; 2001; 7 days; functionality of mp verified by RIA; dose-response; peptides.

P2091 Riemenschneider,Th., Ruf,C., Kratzsch,H.C., Ziegler,M., Spath,G. Arterial, portal or combined arterio-portal regional chemotherapy in experimental liver tumours. J.Cancer Res.Clin.Oncol. 1992; 118(--):597-600. >>> Uridine, fluorodeoxy-; Heparin; Saline; IA (hepatic); IV (hepatic portal); rat; 2ML2; 7 days; tissue perfusion (tumor); cancer; hepatic artery accessed via gastroduodenal artery; portal vein via ileocolic vein; animal info (SD, F, 120-150 g).

P2089 Riemenschneider,T., Ruf,C., Kratzsch,H.C., Ziegler,M., Spath,G. Arterial, portal or combined arterio-portal regional chemotherapy in experimental liver tumours?. J.Cancer Res.Clin.Oncol. 1992; 118(--):596-600. >>> Uridine, fluorodeoxy-; Heparin; Saline; IA (hepatic); IV (hepatic portal); rat; 2ML2; 7 days; Cancer; 5000 IU/kg of heparin dissolved in saline; animal info (SD, F, 120-150 g).

R0084 Daemen,M.J.A.P., Thijssen,H.H.W., Struyker-Boudier,H.A.J. Pharmacokinetic considerations in local drug delivery. Adv.Drug Delivery Review 1991; 6(--):1-18. >>> Hippuric acid; 125I tracer; Radio-isotopes; IA (suprarenal); rat; no duration posted; tissue perfusion.

P2594 Andersen,D.E., Reid,S.D., Moon,T.W., Perry,S.F. Metabolic effects associated with chronically elevated cortisol in rainbow trout (Oncorhynchus mykiss). Can.J.Fish.Aquat.Sci. 1991; 48(-9-):1811-1817. >>> Cortisol; Cyclodextrin, B-; IA (dorsal aorta); fish (rainbow trout); 2001; 10-14 days; controls received mp w/ vehicle or sham operation; functionality of mp verified by RIA of plasma levels; stress from surgery caused hyperglycemia (p.816) for 22 hours; "Mini-osmotic pumps. . .were an effective method for chronically elevating cortisol titers in trout."; Molecusol HBP is a beta-cyclodextrin.

P2015 Stepkowski,S.M., Chen,H., Daloze,P., Kahan,B.D. Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat. Transplantation 1991; 51(-1-):22-26. >>> Rapamycin; Dimethylacetamide; PEG 400; Tween 80; IA (innominate); IV (lumbar); rat; 2002; 14 days; tissue perfusion (allograft).

P1946 Kamei,T., Callery,M.P., Flye,M.W. Intragraft delivery of 16, 16-dimethyl PGE2 induces donor-specific tolerance in rat cardiac allograft recipients. Transplantation 1991; 51(-1-):242-246. >>> Prostaglandin E2 analogue; Ethanol; Saline; IA (innominate); IP; IV (lumbar); rat; 2ML1; 2ML2; 1, 2 weeks; tissue perfusion (cardiac allograft); immunology; pumps implanted IP.

P1890 Alarid,E.T., Cunha,G.R., Young,P., Nicoll,C.S. Evidence for an organ- and sex-specific role of basic fibroblast growth factor in the development of the fetal mammalian reproductive tract. Endocrinology 1991; 129(-4-):2148-2154. >>> Antibody, anti-fibroblast growth factor; Glycerol; Sodium azide; IA (suprarenal); rat; 2002; 14 days; tissue perfusion (graft); peptides.

R0089 Amkraut,A., Eckenhoff,J.B., Nichols,K. Osmotic delivery of peptides and macromolecules. Adv.Drug Delivery Review 1990; 4(--):255-276. >>> Atrial natriuretic factor; Cholecystokinin; Colony-stimulating factor, G.; Glucagon; Insulin; Interleukin-2; Interleukin-3; Melatonin; Nerve growth factor; Neurotensin; Prolactin; Theophylline; CSF/CNS; IA (femoral); intrasplenic; IP; SC; no duration posted; peptides; ALZA-authored, review of peptide delivery issues and applications; tissue perfusion (spleen).

P3291 Norman J., Tsau,Y., Bacay,A., Fine,L.G. Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: role of the epidermal growth factor receptor. Clin.Sci. 1990; 78(--):445-450. >>> Epidermal growth factor; Saline; IA (renal); rat; 2001; 8 days; controls received mp w/saline; peptides; medical category: renal; skc.

P1690 Liu,L., Russell,S.M., Nicoll,C.S. Analysis of the role of basic fibroblast growth factor in growth and differentiation of transplanted fetal rat paws and intestines. Endocrinology 1990; 126(-3-):1764-1770. >>> Antibody, anti-fibroblast growth factor; Fibroblast growth factor; Glycerol; Heparin; Saline; Sodium azide; Sodium citrate; IA (renal); rat; 2001; 2002; 6-11 days; tissue perfusion: tissue graft; good methods for FGF/pg. 1765; peptides; basic FGF used.

P1651 Spencer,E.M., Si,E.C.C., Liu,C.C., Howard,G.A. Parathyroid hormone potentiates the effect of insulin-like growth factor-I on bone formation. Acta Endocrinol. 1989; 121(--):435-442. >>> Insulin-like growth factor I; Parathyroid hormone; Glycerol; Heparin; Sodium azide; Tris buffer; IA (iliac); rat; 2001; 7 days; functionality of mp verified by residual volume; peptides.

P1646 Ruiz,P., Coffman,T.M., Klotman,P.E., Sanfilippo,F. Association of chronic thromboxane inhibition with reduced in situ cytotoxic T cell activity in rejecting rat renal allografts. Transplantation 1989; 48(-4-):660-666. >>> OKY-046; Saline; IA (renal); rat; 4 days; tissue perfusion; OKY-046 is a thromboxane synthetase inhibitor.

P1644 Gallo,J.M., Clark,L.N., Rubino,J.T. Pump delivery of azidothymidine: potential for constant concentrations and improved brain delivery. J.Controlled Release 1989; 9(--):249-253. >>> Azidothymidine; IA (carotid); rat; 2001; 3-7 days; Dose-response; blood levels; comparison of IV injections vs. mp; good methods; antiviral; alkaline pH of 11 increased solubility and stability of AZT.

P1606 Li,P., Jackson,E.K. Enhanced slow-pressor response to angiotensin II in spontaneously hypertensive rats. J.Pharmacol.Exp.Ther. 1989; 251(-3-):909-921. >>> Angiotensin II; Norepinephrine; Water; IA (renal); IP; IV (jugular); rat; 2002; 1, 2 weeks; dose-response (graph); tissue perfusion; peptides.

P1567 Stepkowski,S.M., Goto,S., Ito,T., Reynolds,K., Didlake,R., Kim,E.K., Kahan,B.D. Prolongation of heterotropic heart allograft survival by local delivery of continuous low-dose cyclosporine therapy. Transplantation 1989; 47(-1-):17-23. >>> Cyclosporin; Cremophor; IA (innominate); IV; rat; 2002; 14 days; dose-response; comparison of gavage vs. mp infusion; functionality of mp verified by blood levels; tissue perfusion (heart allograft).

P1480 Koelle,G.B., Han,M.S. Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl phosphorofluoridate administration. Proc.Natl.Acad.Sci. 1989; 86(-11-):4331-4333. >>> Glutamine, glycyl-l-; Plasma, heat-inactivated cat; Water; IA (abdominal aorta); rat; 2001; 2 days; controls received IA catheter, w/ no pump; tissue perfusion.

P1431 Coffman,T.M., Ruiz,P., Sanfilippo,F., Klotman,P.E. Chronic thromboxane inhibition preserves function of rejecting rat renal allografts. Kidney Int. 1989; 35(--):24-30. >>> OKY-046; Saline; IA (renal); rat; 4 days; schematic of OP ligated to aortic cuff of allograft; tissue perfusion; cancer/immunology.

P1454 Ruers,T.J., Daemen,M.J., Thifssen,H.H., van der Linden,C.J., Buurman,W.A. Sensitivity of graft rejection in rats to local immunosuppressive therapy. Transplantation 1988; 46(-6-):820-825. >>> Budesonide; Propanediol; Water; IA (carotid); IV (jugular); rat; 2ML2; 14 days; dose-response; schematic shows IA catheter w/ mp; functionality of mp verified by plasma levels; tissue perfusion (heart); cancer/immunology.

P1384 Liu,L., Nicoll,C.S. Evidence for a role of basic fibroblast growth factor in rat embryonic growth and differentiation. Endocrinology 1988; 123(-4-):2027-2031. >>> Antibody, fibroblast growth factor; Serum, rabbit; Fibroblast growth factor; Glycerol; Heparin, porcine; Sodium azide; Sodium citrate; Water; IA (renal); rat; 2001; 2002; 6, 10 days; antibody, transplanted embryo in kidney was perfused using renal artery; peptides; tissue perfusion; basic FGF used.

P1356 Daemen,M.J.A.P., Smits,J.F.M., Thijssen,H.H.W., Struyker-Boudier,H.A.J. Pharmacokinetic considerations in target-organ directed drug delivery. Trends Pharmacol.Sci. 1988; 9(--):138-141. >>> Acenocoumarol; Edetic acid; Hippuric acid; Propranolol; Radio-isotopes; 125I tracer; 51Cr tracer; IA (renal); rat; no duration posted; targeted delivery; tissue perfusion; antihypertensive.

P1352 Riemenschneider,T., Ruf,C., Spath,G., Stuhldreier,G., Elmouaouy,A. Continuous or bolus chemotherapy with 5-fluoro-2-deoxyuridine in transplanted experimental liver tumors. J.Cancer Res.Clin.Oncol. 1988; 114(--):482-486. >>> Uridine, fluorodeoxy-; Heparin; Saline; IA (hepatic); rat; 2ML2; 7 days; regional chemotherapy; comparison of IA injections vs. mp infusion; cancer/immunology; tissue perfusion.

P1340 Daemen,M.J.A.P., Vervoort-Peters,H.T.M., Thijssen,H.H.W. Pharmacokinetic evaluation of local drug delivery: the intratesticular and intrarenal administration of acenocoumarol in the rat. J.Pharm.Pharmacol. 1988; 40(--):283-285. >>> Acenocoumarol; PBS; Water; IA (renal); IA (suprarenal); IA (testicular); intratesticular; rat; 2001; 5 days; mp connected to catheter; functionality of mp verified by plasma and tissue levels; tissue perfusion; dose-response (table).

P1451 Ruers,T.J.M., Buurman,W.A., Van Boxtel,C.J., van der Linden,C.J., Kootstra,G. Immunohistological observations in rat kidney allografts after local steroid administration. J.Exp.Med. 1987; 166(--):1205-1220. >>> Prednisolone; Water; IA (suprarenal); rat; 2ML2; 14 days; functionality of mp verified by serum levels; tissue perfusion (kidney).

P1083 Hexum,T.D., Russett,L.R. Plasma enkephalin-like peptide response to chronic nicotine infusion in guinea pig. Brain Research 1987; 406(-1/2-):370-372. >>> Nicotine; Saline; IA (carotid); guinea-pig; 2002; 10 days; mp connected to indwelling catheter in carotid artery.

P0982 Ruers,T.J.M., Buurman,W.A., van der Linden,C.J., Kootstra,G. Local inhibition of major histocompatibility complex class II induction within the graft: An effective way to induce immunosuppression. Transplant.Proc.XIX 1987; 19(-1-):246-248. >>> Prednisolone; Saline; Water; IA (suprarenal); IP; rat; 2ML2; 14 days; controls received mp w/saline; immunology; tissue perfusion.

P0981 Nilsson,A., Isgaard,J., Lindahl,A., Peterson,L., Isaksson,O. Effects of unilateral arterial infusion of GH and IGF-I on tibial longitudinal bone growth in hypophysectomized rats. Calcif.Tissue Int. 1987; 40(-2-):91-96. >>> Growth hormone, human; Insulin-like growth factor I; Prolactin, ovine; Saline, heparinized; IA (femoral); rat; 2002; 14 days; controls were untreated; mp connected to catheter in femoral artery; replacement therapy (hypophysectomy); local IA infusion; peptides.

P2427 Schlechter,N.L., Russell,S.M., Spencer,E.M., Nicoll,C.S. Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc.Natl.Acad.Sci. 1986; 83(--):7932-7934. >>> Growth hormone, rat; Somatomedin C, human; Serum, rabbit; Antiserum, human somatomedin C, rabbit; Glycerol; Sodium azide; Water, double-distilled; Sodium heparin; IA (right superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); peptides; minipump and catheter were implanted in abdominal cavity; some rats received co-infusion of GH and rabbit serum or antiserum.

P0937 Cooke,P.S., Higa,L., Nicoll,C.S. Insulin but not GH directly stimulates growth of transplanted fetal rat paws. Am.J.Physiol. 1986; 251(--):E624-E629. >>> Growth hormone; Insulin; Glutamic acid; Glycerin; HCl; Sodium hydroxide; Phenol; Saline; Water; IA (renal); rat; 2001; 7 days; controls received mp w/saline; mp conn. to catheter in renal artery; comparison of sc inject. vs. mp infusion; repl. therapy (hypophysectomy); peptides; tissue perfusion.

P0912 Ruers,T.J.M., Buurman,W.A., Smits,J.F.M., van der Linden,C.J., van Dongen,J.J., Spronken,E.E.M., Kootstra,G. The effect of intrarenal steroid infusion on rat renal allograft rejection. Transplant.Proc.XVIII 1986; 18(-5-):1106-1107. >>> Prednisolone; Water; IA (suprarenal); IP; rat; no duration posted; immunology; tissue perfusion.

P0782 Ruers,T.J.M., Buurman,W.A., Smits,J.F.M., van der Linden,C.J., van Dongen,J.J., Struyker-Boudier,H.A.J., Kootstra,G. Local treatment of renal allografts, a promising way to reduce the dosage of immunosuppressive drugs. Transplantation 1986; 41(-2-):156-161. >>> Prednisolone; Saline; Water; IA (suprarenal); IA (testicular); IP; IV (jugular); rat; 2ML2; 13 days; mp connected to catheter in suprarenal or testicular artery or jugular vein; states pump rate as 6 ul/hr; dose-response (serum urea levels); kidney transplant; immunosuppression; half-life; mp infusion prolonged graft survival; tissue perfusion.

P0771 Schlechter,N.L., Russell,S.M., Greenberg,S., Spencer,E.M., Nicoll,C.S. A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion. Am.J.Physiol. 1986; 250(--):E231-E235. >>> Growth hormone, rat; Prolactin, ovine; Glycerol; Sodium azide; IA (superior vesicle); rat; 2001; 7 days; replacement therapy (hypophysectomy); mp connected to catheter in superior vesicle artery; detailed description and diagram of catheter apparatus; constant and pulsed delivery of GH; peptides.

P0707 Smits,J.F., van Essen,H., Struyker-Boudier,H.A.J., Lappe,R.W. Lack of renal vasodilation during intrarenal infusion of synthetic Atriopeptin II in conscious intact SHR. Life Sci. 1986; 38(-1-):81-87. >>> Saline; IA (renal); rat; 2001; 2-3 days; mp attached to catheter in suprarenal artery; tissue perfusion.

P0682 LeNoble,L.M.L., Lappe,R.W., Brody,M.J., Struyker-Boudier,H.A.J., Smits,J.F.M. Selective efferent chemical sympathectomy of rat kidneys. Am.J.Physiol. 1985; 249(-4-):R496-R501. >>> Saline; IA (renal); rat; 2001; no duration posted; pump used only to flush catheter and keep it patent when not in use; tissue perfusion.

P0543 Smits,J.F.M., Brody,M.J. Activation of afferent renal nerves by intrarenal bradykinin in conscious rats. Am.J.Physiol. 1984; 247(-6-):R1003-R1008. >>> Saline; IA (renal); rat; 3-5 days; mp used only to keep catheters open prior to second part of surgery&prior to drug infusion; tissue perfusion.

P0537 Kleinjans,J.C.S., Smits,J.F.M., van Essen,H., Kasbergen,C.M., Struyker Boudier,H.A.J. Hemodynamic characterization of hypertension induced by chronic intrarenal or intravenous infusion of norepinephrine in conscious rats. Hypertension 1984; 6(-5-):689-699. >>> Norepinephrine; Saline; IA (renal); IV (jugular); rat; 2001; 5 days; comparison of acute infusion by Percidor pump vs. iv or ia mp infusion; dose-response data; 2 doses NE - 4 and 36 ug/kg/hr; tissue perfusion.

P0468 Kleinjans,J.C.S., Smits,J.F.M., Kasbergen,C.M., van Essen,H., Struyker-Boudier,H.A.J. Evaluation of renal function during intrarenal norepinephrine infusion in conscious rats. Renal Physiol. 1984; 7(--):243-250. >>> Norepinephrine; Ascorbic acid; Saline; IA (renal); IV (jugular); rat; 5 days; comparison of iv vs. ia mp infusion; dose-response data; tissue perfusion.

T0004 Kleinjans,J.C.S. Stimulation of renal adrenergic mechanisms as a model for the development of hypertension. Dissertation, State University of Limburg, Netherlands 1983; (--):-. >>> Captopril; Norepinephrine; Radio-isotopes; 3H tracer; Ascorbic acid; Saline; IA (renal); IP; IV (jugular); rat; 5 days; 6 diff. exp. done; exp in ch. 5 used captopril in ip pump, sc pump delivered saline or NE w/ ascorbic acid via ia catheters; stability of NE in pump verified; tissue perfusion; antihypertensive.

P0496 Kleinjans,J.C.S., Smits,J.F.M., Kasbergen,C.M., Struyker-Boudier,H.A.J. Body fluid and salt homeostasis during hypertension caused by chronic intrarenal norepinephrine infusion in conscious rats. J.Hypertens. 1983; 1(-2-):207-209. >>> Norepinephrine; Ascorbic acid; Saline; IA (renal); rat; 5 days; dose-response data; tissue perfusion.

P0348 Kleinjans,J.C.S., Smits,J.F.M., Kasbergen,C.M., Vervoort-Peters,H.T.M., Struyker-Boudier,H.A.J. Blood pressure response to chronic low-dose intrarenal noradrenaline infusion in conscious rats. Clin.Sci. 1983; 65(--):111-116. >>> Norepinephrine; Ascorbic acid; Saline; IA (renal); IV (jugular); rat; 2001; 5 days; comparison of i.v. vs. i.a. infusion; tissue perfusion.

P0287 Smits,J.F.M., Kasbergen,C.M., van Essen,H., Kleinjans,J.C., Struyker-Boudier,H.A.J. Chronic local infusion into the renal artery of unrestrained rats. Am.J.Physiol. 1983; 244(--):H304-H307. >>> Saline; IA (renal); rat; 2001; 2-14 days; pumps replaced after days 2 and 7; tissue perfusion.