References on the Intracerebroventricular Administration of Agents Using ALZET® Osmotic Pumps

16332 Sophie Dutheil,, Isabelle Watabe,, Karina Sadlaoud,, Alain Tonetto,, Brahim Tighilet2  Journal of Neuroscience 2016; 36(-23-):6199-6212. >>> Brain-derived neurotrophic factor, K252a; Saline; CSF, artificial; CSF/CNS (ventricles); Cat; 2ML4; Controls received mp w/ saline; animal info (adult, male cat, 4-5 kg); dose-response (pg 6205, 6206); behavioral testing (rotating beam experimental device test); peptides;.

16330 Drougard, A., Fournel, A., Marlin, A., Meunier, E., Abot, A., Bautzova, T., Duparc, T., Louche, K., Batut, A., Lucas, A., Le-Gonidec, S., Lesage, J., Fioramonti, X., Moro, C., Valet, P., Cani, P. D., Knauf, C. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. Sci Rep 2016; 6(--):31849. >>> Apelin; CSF, artificial; CSF/CNS (lateral ventricle); Mice; 2004; Controls received mp w/ vehicle; animal info (C57Bl6/J mice, 13-15 week old); animal info (C57Bl6/J mice, 13-15 week old);“stability of apelin and the duration of the treatment were compatible with the stability of the molecule” (pg. 8); peptides; anesthetised mice with isoflurane; Brain coordinates − 1 mm lateral, − 0.2 mm anteroposterior from the bregma and − 1.7 mm deep; Dose (20 nM);.

16305 Apkarian, A. V., Mutso, A. A., Centeno, M. V., Kan, L., Wu, M., Levinstein, M., Banisadr, G., Gobeske, K. T., Miller, R. J., Radulovic, J., Hen, R., Kessler, J. A. Role of adult hippocampal neurogenesis in persistent pain. Pain 2016; 157(-2-):418-28. >>> AraC; Saline; CSF/CNS (lateral ventricle); mice; 1002; Controls received mp w/ vehicle; animal info (C57Bl/6 male mice, 8-9 wks old); dose-response (pg 421); behavioral testing (touch and cold sensitivity of injured paw, Von Frey, Tail suspension test, Open field, Black-box emergence test);“Mice show fullbehavioral and functional recovery soon after surgery” pg 419; Brain coordinates; 0.4mmposterior to the bregma, 1mmlateral to the midline, and 2 mm ventral to the skull.

16301 Bhagat, S. M., Butler, S. S., Taylor, J. R., McEwen, B. S., Strittmatter, S. M. Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood. Mol Psychiatry 2016; 21(-9-):1281-9. >>> Nogo Receptor (310) ecto-Fc; PBS; CSF/CNS (right lateral ventricle); mice; 28 days; Controls received mp w/ vehicle; animal info (Adult male C57BL6/J mice (4–6 mo old)); functionality of mp verified by behavioral endpoints; functionality of mp verified by behavioral endpoints; behavioral testing (fear conditioning, extinction training, extinction retrieval, fear reacquisition, cue selectivity); cyanoacrylate adhesive; NgR(310)ecto-Fc aka Nogo Receptor(310) ecto-Fc; Dose (0.2 mg); Resultant CNS protein levels;.

16287 de Kloet, A. D., Pitra, S., Wang, L., Hiller, H., Pioquinto, D. J., Smith, J. A., Sumners, C., Stern, J. E., Krause, E. G. Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice. Endocrinology 2016; 157(-8-):3167-80. >>> Compound 21; CSF, artificial; Saline; CSF/CNS (lateral ventricle); Mice, rats; Controls received mp w/ vehicle; animal info (Male mice (10–12 wk old) or rats (4–6 wk old)); functionality of mp verified by plasma vasopressin levels; ALZET brain infusion kit used; ALZET brain infusion kit used; Brain coordinates; from bregma 0.2 mm posterior, 1.0 mm lateral, and 2.5 mm ventral; Dose (7.5 ng/kg/hr);.

16267 Varvel, N. H., Grathwohl, S. A., Degenhardt, K., Resch, C., Bosch, A., Jucker, M., Neher, J. J. Replacement of brain-resident myeloid cells does not alter cerebral amyloid-beta deposition in mouse models of Alzheimer's disease. J Exp Med 2015; 212(-11-):1803-9. >>> Valganciclovir; PBS; CSF/CNS (ventricle); mice; 2004; Controls received mp w/ vehicle; animal info (Female hemizygous TK mice crossed w/ male hemizygous APPPS1 or hemizygous APP23); ALZET brain infusion kit 3 used; good methods (pg. 11807); post op. care (paracetamol, i.p. 5 mg/kg daily; acetaminophen i.p. 5 mg/kg daily); brain tissue distribution; Dental cement used; Cannula placement verified via staining; anesthetized using ketamine and xylazine; Brain coordinates; from bregma: +0.1 mm anteroposterior, 1.0 mm lateral, and 2.5 mm dorsoventral; Dose (50 mg/ml);.

16257 Ahl, M., Avdic, U., Skoug, C., Ali, I., Chugh, D., Johansson, U. E., Ekdahl, C. T. Immune response in the eye following epileptic seizures. J Neuroinflammation 2016; 13(-1-):155. >>> Antibody, CX3CR1; saline; CSF/CNS (ventricle); rat; Controls were Electrode- and cannulae-implanted nonstimulated rats; animal info (Adult male Sprague Dawley rats, 200-250 g); functionality of mp verified by EEG; functionality of mp verified by EEG; brain tissue distribution; Cannula placement verified via expression of antibody; Dose (1 mm posterior and 1.5 mm lateral to the bregma and 3.5 mm ventral to the flat skull position (with the bregma as reference)); Interesting“Our results are the first evidence that epileptic seizures induce an immune response in the retina. It has a potential to become a novel non-invasive tool for detecting brain inflammation through the eyes” pg. 1;.

16251 Sooy, K., Noble, J., McBride, A., Binnie, M., Yau, J. L., Seckl, J. R., Walker, B. R., Webster, S. P. Cognitive and Disease-Modifying Effects of 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. Endocrinology 2015; 156(-12-):4592-603. >>> UE2316; DMSO, PEG; CSF, artificial; SC, CSF/CNS (ventricles); mice; 2004; Controls received mp w/ vehicle; animal info (Male C57BL/6 mice, 8-10 months, 24 month); functionality of mp verified ; 50:50 DMSO-PEG used; dose-response (p 4596); behavioral testing (memory in passive avoidance, Y Maze, Open field, spontaneous alternation, morris water maze); brain tissue distribution; Dose (5 mg/kg/d, 10 mg/kg/d, 15 mg/kg/d, 100 ng/h);.

16250 Smith, P. Y., Hernandez-Rapp, J., Jolivette, F., Lecours, C., Bisht, K., Goupil, C., Dorval, V., Parsi, S., Morin, F., Planel, E., Bennett, D. A., Fernandez-Gomez, F. J., Sergeant, N., Buee, L., Tremblay, M. E., Calon, F., Hebert, S. S. miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet 2015; 24(-23-):6721-35. >>> miR-132 mimics; In vivo transfection agent; CSF/CNS (ventricle); mice; 2006; Controls received mp w/ vehicle; animal info (Twelve-month-old 3xTg-AD WT mice); ALZET brain infusion kit 2 used; post op. care (50Ǩl Anafen (1 mg/ml) and 500Ǩl saline (0.9%)); behavioral testing (Barnes maze test); In vivo transfection agent used: jetPEI; Dose (1.8Ǩg/day); Brain coordinates; ventricle A/P =−0.22 M/l = 0.0 D/v = −3.5.

16236 Robins, S. C., Trudel, E., Rotondi, O., Liu, X., Djogo, T., Kryzskaya, D., Bourque, C. W., Kokoeva, M. V. Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One 2013; 8(-10-):e78236. >>> Uridine, bromodeoxy; uridine, ethynyldeoxy; CSF, artificial; CSF/CNS (right lateral ventricle); mice; 1007D; animal info: NG2-CreER:tdTomato mice; functionality of mp verified post brain removal; Plastics One infusion kit used; brain tissue distribution; delayed delivery (2 days); delayed delivery (2 days); Dose: 30 ug/day (BrdU and EdU); Brain coordinates; 0.3 mm (anteroposterior), 1.0 mm (lateral), and 2.5 mm (dorsoventral, below skull).

16233 Rabinovich-Toidman, P., Rabinovich-Nikitin, I., Ezra, A., Barbiro, B., Fogel, H., Slutsky, I., Solomon, B. Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS. PLoS One 2015; 10(-11-):e0143420. >>> Antibody, monoclonal, BBS; CSF/CNS (right lateral ventricle); mice; 2006; Controls received mp w/ isotype-matched non relevant MAb; animal info (male Hemizygous B6SJLTgN (SOD1G93A) 1 Gur mice); brain infusion cannula used; neurodegenerative (ALS); immunology; antibodies infused; MAb aka Monoclonal antibody; Ketamine and Xylazine anesthesia; Dose (1.5 mg/mL); Brain coordinates; l-2mm [Bregma] in the anterio-posterior direction, 2.8mm in mediolateral direction and 3mm depth.

16232 Prokop, S., Miller, K. R., Drost, N., Handrick, S., Mathur, V., Luo, J., Wegner, A., Wyss-Coray, T., Heppner, F. L. Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice. J Exp Med 2015; 212(-11-):1811-8. >>> Ganciclovir; CSF, artificial; CSF/CNS (lateral ventricles); mice; 2001; Controls received mp w/ vehicle; animal info (APPPS1 transgenic mice); brain infusion cannula used; neurodegenerative (Alzheimer’s); Dose (2.5 mg/ml); Therapeutic indication (Alzheimer’s Disease);.

16230 Pikor, N. B., Astarita, J. L., Summers-Deluca, L., Galicia, G., Qu, J., Ward, L. A., Armstrong, S., Dominguez, C. X., Malhotra, D., Heiden, B., Kay, R., Castanov, V., Touil, H., Boon, L., O'Connor, P., Bar-Or, A., Prat, A., Ramaglia, V., Ludwin, S., Turley, S. J., Gommerman, J. L. Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation. Immunity 2015; 43(-6-):1160-73. >>> Anti-interleukin 22, anti-interleukin 17, LymphotoxinǞR-Ig; Immunoglobulin; CSF/CNS (cerebroventricular); mice; 2004; Controls received mp w/ vehicle; animal info (SJL/J mice,); animal info (SJL/J mice,); dose-response (pg 1166); peptides; Fibroblast remodeling in vivo; Dose (2 mg/ml (LTBR), 2.25 mg/ml (IL));.

16229 Perianes-Cachero, A., Canelles, S., Aguado-Llera, D., Frago, L. M., Toledo-Lobo, M. V., Carrera, I., Cacabelos, R., Chowen, J. A., Argente, J., Arilla-Ferreiro, E., Barrios, V. Reduction in Abeta-induced cell death in the hippocampus of 17beta-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone. J Neurochem 2015; 135(-6-):1257-71. >>> Amyloid protein, beta (25-35); ICI 182,780; saline; CSF/CNS (right cerebral ventricle); rat; 2002; Controls received mp w/ vehicle; animal info (female Wistar rats, 8 weeks); brain infusion kit used; peptides; Amyloid beta-peptide induces cell death, learning and memory, hippocampal somatostatinergic system; Dose (300 pmol/day (A-beta), 600 fmol/day (ICI)); Brain coordinates; (-0.3 mm anteroposterior, 1.1 mm lateral).

16228 Pazos, P., Lima, L., Tovar, S., Gonzalez-Touceda, D., Dieguez, C., Garcia, M. C. Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Sci Rep 2015; 5(--):17977. >>> Interleukin-18; Saline; CSF/CNS (lateral ventricle); mice; 1007D; Controls received mp w/ vehicle; animal info (10–11 weeks old Il18r1-KO, WT mice); brain infusion kit used; behavioral testing (cold-challenge); brain tissue distribution; effects of interleukin-18 on food intake, body composition and iWAT morphology; Dose (20Ǩg/mouse/7 days,);.

16226 Parsi, S., Smith, P. Y., Goupil, C., Dorval, V., Hebert, S. S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids 2015; 4(--):e256. >>> miR-16 mimic; Saline; CSF/CNS (ventricle); mice; 1007D; Controls received mp w/ vehicle; animal info (Wild-type mice (C57BL/6, female, 2 months old)); ALZET brain infusion kit 2 used; dose-response (pg. 2); neurodegenerative (Alzheimer’s); post op. care (Anafen); replacement therapy (miRNA replacement therapy); brain tissue distribution; delayed delivery (12 hours delivery/day); potent inhibitor of amyloid precursor protein (APP) and BACE1 expression, AǞpeptide production, and Tau phosphorylation in cells; Dose (4.2Ǩg/Ǩl); Brain coordinates; ventricle A/P =−0.22 M/L = 0.5 D/v = 3.5).

16222 Ono, D., Honma, S., Honma, K. Circadian PER2::LUC rhythms in the olfactory bulb of freely moving mice depend on the suprachiasmatic nucleus but not on behaviour rhythms. Eur J Neurosci 2015; 42(-12-):3128-37. >>> D-Luciferin K; Saline, physiological; CSF, artificial; IP, CSF/CNS (lateral ventricle); mice; 2002, 1004; Controls received mp w/ vehicle; animal info (Male and female mice, C57BL/6j, 3.5-7 months); functionality of mp verified by measurement of bioluminescence; functionality of mp verified by measurement of bioluminescence; Isoflurane anesthesia; circadian rhythm measurements; Dose (100 mM);.

16209 McMillin, M., Frampton, G., Quinn, M., Divan, A., Grant, S., Patel, N., Newell-Rogers, K., DeMorrow, S. Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling. Mol Endocrinol 2015; 29(-12-):1720-30. >>> Oligonucleotide, Vivo-morpholino; CSF/CNS (lateral ventricle); rat; Controls received mp w/ vehicle; brain infusion kit used; brain tissue distribution; Dose (1 mg/kg / d);.

16254 Yongzhi Li,, Keiko Tanaka,, Li Wang,, Yasuhito Ishigaki, Nobuo Kato4  Journal of Experimental Medicine 2015; 237(--):329-338. >>> NMDAR-CSF; saline; CSF/CNS (left lateral ventricle); mice; 1004; Controls received mp w/ vehicle; animal info: C57BL/6 male mice (age: 8 weeks; weight: 22-24 g); functionality of mp verified by behavioral tests; neurodegenerative (anti-NMDAR encephalitis); behavioral testing (spontaneous locomotor activity, open field test, NOR test, Morris Water maze); Immunology, immunotherapy; brain tissue distribution; cyanoacrylate adhesive;“The diffusion of methlene blue in all ventricles was confirmed in all mice examined” pg 331; Cannula placement verified via methylene blue or thionine solution injection into brain; NMDAR-CSF aka Anti-N-methyl-D-aspartate receptor-CSF; CSF collected from patients with anti-NMDAR encephalitis; Brain coordinates; 0.4 mm posterior to bregma, 1.0 mm lateral to the lambda point, and 2.0 mm deep from the dural surface.

16196 Lee, Chun-Lin, Lin, Pei-Ying, Hsu, Ya-Wen, Pan, Tzu-Ming  Journal of Functional Foods 2015; 18(--):387-399. >>> Amyloid protein, beta (40); Acetonitrile, trifluoroacetic acid; CSF/CNS (left ventricle); rat; 2004; Controls received mp w/ vehicle; animal info: Male Sprague Dawley (SD) rats at 6–8 weeks; functionality of mp verified by behavior tests; 35% acetonitrile, 0.1% trifluoroacetic acid; dose-response (pg 390); behavioral testing (Morris water maze; reference memory task, probe test, and working memory task); brain tissue distribution; peptides; cannula was inserted 4.0 mm into the left ventricle and attached to the skull with dental cement; Dose: 0.28 uL/h.

16193 Kim, J. S., Brownjohn, P. W., Dyer, B. S., Beltramo, M., Walker, C. S., Hay, D. L., Painter, G. F., Tyndall, J. D., Anderson, G. M. Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14. Endocrinology 2015; 156(-11-):4152-62. >>> Peptide-3, RF amide-related; GJ14; CSF/CNS (left lateral ventricle); mice; 1007D; Controls received mp w/ vehicle; animal info: Female C57BL/6 mice (8 wk old); functionality of mp verified by behavior testing; behavioral testing (elevated plus maze and open field tests for 5 minutes each); peptides; RFRP-3 aka Peptide-3, RF amide-related; GJ14 is a NPFF1R antagonist with moderate antagonism at NPFF2R; G-protein coupled neuropeptide FF (NPFF) receptors belong to the RFamide receptor family and are referred to as NPFF1R (also known as GPR147) and NPFF2R (GPR74); Dose: 2 nmol/mouse/d (RFRP-3); 20 nmol/mouse/d (GJ14).

16192 Kim, J., Yoon, H., Horie, T., Burchett, J. M., Restivo, J. L., Rotllan, N., Ramirez, C. M., Verghese, P. B., Ihara, M., Hoe, H. S., Esau, C., Fernandez-Hernando, C., Holtzman, D. M., Cirrito, J. R., Ono, K., Kim, J. microRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain. J Neurosci 2015; 35(-44-):14717-26. >>> anti-miR-33; CSF/CNS (intracerevrovenctricular); Mice; Controls received negative control; animal info: mir-33 knock-out mice, two month-old APPsw/PSEN1_9 (APP/PS1) transgenic mice; neurodegenerative (Alzheimer’s); immunology; brain tissue distribution; Dose: 30 ug/d.

16185 Su, C. H., Tsai, C. Y., Chang, A. Y., Chan, J. Y., Chan, S. H. MRI/DTI of the Brain Stem Reveals Reversible and Irreversible Disruption of the Baroreflex Neural Circuits: Clinical Implications. Theranostics 2016; 6(-6-):837-48. >>> Angiotensin II; CSF/CNS (ventricle); Mice; 1007D; animal info (male, C57BL6, adult); cardiovascular; peptides; bp measured using radiotelemetry (DSI); Dose (7.5 ug/hr);.

16181 Stephanie R. Sisley,, Deanna M. Arble,, Adam P. Chambers,, Ruth Gutierrez-Aguilar,, Yanlin He,, Yong Xu,, David Gardner,, David D. Moore,, Randy J. Seeley,, Darleen A. Sandoval  Diabetes 2016; (--):1-35. >>> Vitamin D3, 1,25-dyhydroxy; Cyclodextrin; hydroxypropyl-B-; CSF/CNS (third ventricle); Rat; 1004; Controls received mp w/ vehicle; animal info (male, Long Evans, adult); dose-response (Supplementary Figure 3); obesity; Dose (-.264 ug/day); Brain coordinates (i3vt 2.2A/P, 7.8D/V);.

16132 Hamilton, L. K., Dufresne, M., Joppe, S. E., Petryszyn, S., Aumont, A., Calon, F., Barnabe-Heider, F., Furtos, A., Parent, M., Chaurand, P., Fernandes, K. J. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease. Cell Stem Cell 2015; 17(-4-):397-411. >>> Ara-C; Oleic Acid; AB142089; BSA; CSF/CNS (cerebroventricular); mice; 1007D; 1004; Controls received mp w/ vehicle; animal info: 2-month-old WT or 3xTg-AD mice; functionality of mp verified by Analysis of brain sections by IMS; cancer; dose-response (pg 407); neurodegenerative (NSC impairment); enzyme inhibitor (SCD-1 inhibitor– AB142089); Dose: 500 mM Oleic Acid; 10mM C12 Oleic Acid conjugated to vehicle; 10mM C13 Oleic Acid conjugated to vehicle; 2% AraC; 40 mM SCD-1 inhibitor.

16128 Giachino, C., Boulay, J. L., Ivanek, R., Alvarado, A., Tostado, C., Lugert, S., Tchorz, J., Coban, M., Mariani, L., Bettler, B., Lathia, J., Frank, S., Pfister, S., Kool, M., Taylor, V. A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. Cancer Cell 2015; 28(-6-):730-42. >>> Platelet-derived growth factor - A, human recombinant; CSF/CNS (forebrain lateral ventricle); mice; animal info: adult Hes5::GFP Notch-reporter mice; cancer (gliomas); brain tissue distribution;“increased PDGF signaling induces glioma-like growths from the subventricular zone (SVZ) in mice” (pg 731);.

16127 Ghanbari, A., Esmaeilpour, T., Bahmanpour, S., Golmohammadi, M. G., Sharififar, S., Azari, H. Depletion of neural stem cells from the subventricular zone of adult mouse brain using cytosine b-Arabinofuranoside. Brain Behav 2015; 5(-11-):e00404. >>> Ara-C; Saline; CSF/CNS (right lateral ventricle); Mice; 1007D; Controls received sham operation and mp w/ vehicle; animal info: Five-week-old male C57-BL6 mice; pumps replaced once after 7 days; ALZET brain infusion kit 3 used; good methods (pg 2); post op. care (0.5 mg/kg buprenorphine every 12 h for 48 hours); cyanoacrylate adhesive (Loctite 454); delayed delivery (6-12 hours); Dose: 2% Ara-C in Saline; Brain coordinates; Paxinos mouse brain Atlas: Anterior-Posterior (AP): _0. 2, Medial-Lateral (ML): +0. 9 from the bregma point and Dorsal-Ventral: +2.7 from the top of skull.

16120 Ferrón, Sacri R., Andreu-Agulló, Celia, Mira, Helena, Sánchez, Pilar, Ángeles Marqués-Torrejón, M., Fariñas, Isabel  Nature Protocols 2007; 2(-4-):849-859. >>> Growth Factor; Saline; CSF/CNS (ventricle); mice; 1007D; animal info: any; ALZET brain infusion kit 3 used; good methods (pg 854); post op. care (mice placed on thermal blanket); brain tissue distribution; Cannula placement verified via tissue distribution upon brain removal; Brain coordinates; 0.0 antero-posterior, 0.7 medio-lateral stereotaxic coordinates.

16113 Dorr, A., Kress, E., Podschun, R., Pufe, T., Tauber, S. C., Brandenburg, L. O. Intrathecal application of the antimicrobial peptide CRAMP reduced mortality and neuroinflammation in an experimental model of pneumococcal meningitis. J Infect 2015; 71(-2-):188-99. >>> Antimicrobial peptide, cathelicidin-related; Saline; CSF/CNS (right lateral ventricle); mice; 1007D; Controls received mp w/ saline; animal info: male C57BL/6 mice (weight 19-23 g, aged 2-3 months); ALZET brain infusion kit 2 used; good methods (pg 189-190); brain tissue distribution of CRAMP; peptides; CRAMP aka Cathelicidin-related antimicrobial peptide; Dose: 12 ug/d.

16094 Barth, R. F., Yang, W., Nakkula, R. J., Byun, Y., Tjarks, W., Wu, L. C., Binns, P. J., Riley, K. J. Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors. Appl Radiat Isot 2015; 106(--):251-5. >>> N5-2OH; DMSO; CSF/CNS (intracerebral); IV; rat; 2001D; Controls received mp w/ vehicle, untreated controls; %35 of DMSO; cancer (brain tumor; F98 glioma model); tissue perfusion (brain tissue); brain tissue distribution; Animals were irradiated for 5 min at the MITR-II reactor;“intracerebral. administration of BPA did not increase the tumor boron uptake compared to that obtained following i.v. administration” (pg. 252); Dose: 500 ug.

16077 Zendedel, A., Johann, S., Mehrabi, S., Joghataei, M. T., Hassanzadeh, G., Kipp, M., Beyer, C. Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. Mol Neurobiol 2016; 53(-5-):3063-75. >>> Stromal cell-derived factor-1, alpha; PBS; BSA; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 14 weeks old, 350-400g); 1% BSA used; post op. care (saline rehydration; baytril 0.3 ml SC BID; manual bladder emptying BID); behavioral testing (BBB locomotor test); immunology;.

16076 Zadina, J. E., Nilges, M. R., Morgenweck, J., Zhang, X., Hackler, L., Fasold, M. B. Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine. Neuropharmacology 2016; 105(--):215-27. >>> Morphine; endomorphine analog; Saline; CSF/CNS (intrathecal); rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-400g); half-life (p. 219); behavioral testing (tail flick test; rotarod testing); stability verified by (internal testing; stability>1 year at 37C); pumps primed in 37C saline for 16 hours; used PE-8 IT catheter; Dose (2 ug/hr morphine; 0.056-0.075 ug/hr analog);.

16045 Toklu, H. Z., Bruce, E. B., Sakarya, Y., Carter, C. S., Morgan, D., Matheny, M. K., Kirichenko, N., Scarpace, P. J., Tumer, N. Anorexic response to rapamycin does not appear to involve a central mechanism. Clin Exp Pharmacol Physiol 2016; 43(-9-):802-7. >>> Rapamycin; DMSO; PEG 400; CSF/CNS (third ventricle); Rat; Controls received mp w/ vehicle; animal info (male, F344 Brown Norway, 23-25 months old); 10% DMSO used; used PE-50 tubing; pumps initially filled with aCSF - after one week recovery, pumps replaced with rapamycin or vehicle pump; Dose (30 ug/day); Brain coordinates (1.1 mm posterior to Bregma and 1.6 mm ventral from the skull surface on the midline (medial s- sure), with the nose bar set at 4 mm below the ear bars (below zero)) pg 805;.

16043 Tighilet, Brahim, Dutheil, Sophie, Siponen, Marina I., Noreña, Arnaud J. Reactive Neurogenesis and Down-Regulation of the Potassium-Chloride Cotransporter KCC2 in the Cochlear Nuclei after Cochlear Deafferentation. Frontiers in Pharmacology 2016; 7(--):. >>> AraC; muscimol; NaCl; CSF, artificial; CSF/CNS (fourth ventricle); Cat; 2ML4; Controls received mp w/ vehicle; animal info (male, adult, 4-5kg); post op. care (antibiotics for 7 days; analgesic for 3 days);.

16014 Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T. P., Davern, P. J., Head, G. A. Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice. J Hypertens 2014; 32(-3-):575-86. >>> rilmenidine; Ringer’s solution; CSF/CNS (ventricles); mice; 1002; Controls received mp w/ ringer’s solution vehicle; animal info (BPH/2J and BPN/3J mice); functionality of mp verified by behavioral tests; dose-response (pg 577-582, description and graphical representation); behavioral testing (pg 577; mice were exposed to aversive behavioral stimuli; restraint stress and dirty cage-switch tests conducted); tissue perfusion (brain tissue); antihypertensive; antihypertensive; Dose: 15ug/hr of rilmenidine.

16012 Ghadge, G. D., Pavlovic, J. D., Koduvayur, S. P., Kay, B. K., Roos, R. P. Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1. Neurobiol Dis 2013; 56(--):74-8. >>> antibody, monoclonal anti-SOD1; CSF/CNS (ventricles); mice; animal info: FALS transgenic mice; anti SOD1 monoclonal antibody; neurodegenerative (Amyotrophic Lateral Sclerosis); paper does not mention ALZET much, or pump model;.

15973 Yael Kusne,, Eugenio A. Carrera-Silva,, Anthony S. Perry,, Elisabeth J. Rushing,, Edward K. Mandell,, Justin D. Dietrich,, Andrea E. Errasti,, Daniel Gibbs,, Michael E. Berens,, Joseph C. Loftus,, Christopher Hulme,, Weiwei Yang,, Zhimin Lu,, Kenneth Aldape,, Nader Sanai,, Carla V. Rothlin,, Sourav Ghosh  Science Signaling 2015; 7(-338-):1-15. >>> PZ09; CSF/CNS (ICV); mice; animal info (Six- to 8-week-old female NOD-SCID, TNFa−/−, and control mice); dose-response (pg. 2-5); tissue perfusion (brain; gliobastomas); PZ09 aka small-molecule, benzimidazoleadenosine triphosphate–competitive aPKC inhibitor; xenografts; Dose: 10 uM PZ09.

15916 Kim, D. H., Moon, E. Y., Yi, J. H., Lee, H. E., Park, S. J., Ryu, Y. K., Kim, H. C., Lee, S., Ryu, J. H. Peptide fragment of thymosin beta4 increases hippocampal neurogenesis and facilitates spatial memory. Neuroscience 2015; 310(--):51-62. >>> Ac-SDKP; PBS; CSF/CNS (third ventricle); Mice; 1007D; animal info (male, C57BL6J, 25-28g, 8 weeks old); behavioral testing (Morris water maze); tissue perfusion (third ventricle); peptides; Cannula placement verified via histologic analysis; used Plastics one cannula; brain coordinates;.

15901 Zhou, T. F., Yu, J. G. Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. J Surg Res 2013; 183(-1-):304-12. >>> rhEPO; PBS, BSA; CSF/CNS (left lateral ventricle); rat; animal info: Sprague-Dawley; neurodegenerative (septic encephalopathy); behavioral testing (Morris Water Maze); mp used to infuse rhEPO to study its effect on septic encephalopathy. Application of rhEPO improved skeletal muscle microcirculation and tissue bioenergetics in septic mice. rhEPO improved neuronal apoptosis, and hippocampus-dependent cognitive impairments in a septic model; dose: 5 U/d;.

15898 Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I., Holtzman, D. M. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 2013; 80(-2-):402-14. >>> Antibodies, anti-tau; PBS; CSF/CNS (ICV); mice; 2006; long-term study; controls received mp w/ vehicle anti-AB HJ3.4 and PBS; P301S, tau pathology, 5 months old; pumps replaced every 6 weeks ; neurodegenerative (tau pathology);.

15734 Hannah Botfield,, Ana Maria Gonzalez,, Osama Abdullah,, Anders Dæhli Skjolding,, Martin Berry,, James Pat McAllister,, and Ann Logan  Brain 2013; (-136-):2842-2858. >>> decorin, human recombinant; PBS; CSF/CNS (right lateral ventricle); rat; 2002; controls received mp w/ vehicle; 3 wk old, Sprague-Dawley rats; mp were used to infuse decorin to suppress the inflammatory response in the subarachnoid space following a hemorrhage, and to prevent ventriculomegaly; MRI; dose 5 mg/ml.

15731 Robert W. Regenhardt,, Adam P. Mecca,, Fiona Desland,, Phillip F. Ritucci-Chinni,, Jacob A. Ludin,, David Greenstein,, Cristina Banuelos,, Jennifer L. Bizon,, Mary K. Reinhard, and Colin Sumners  Experimental Physiology 2014; 99(-2-):442-453. >>> Angiotensin (1-7); A779; CSF, artificial; CSF/CNS (left lateral cerebral ventricle); rat; 2006; Controls received mp w/ vehicle; animal info; Male spSHRs, treated until 91 days old (~248 g); ALZET brain infusion kit 1 used; ischemia (ischaemic stroke in the brain); behavioral testing (sunflower seed-eating task to determine fine motor function and neurological deficits); long-term study 6 weeks; peptides delivered; A779 aka (D-Ala7)-Ang-(1–7); Dose: Ang-(1–7) (1.0Ǩg in 0.15Ǩl ACSF h−1);(D-Ala7)-Ang-(1–7) (A779; 2.5Ǩg in 0.15Ǩl ACSF h−1).

15713 Ghanashyam D. Ghadge, John D. Pavlovic,, Sujatha P. Koduvayur,, Brian K. Kay,, Raymond P. Roos  NEUROBIOLOGY OF DISEASE 2013; 56(--):74-78. >>> anti-SOD1 monoclonal antibodies (mAbs); CSF/CNS (intraventricular); mice; not specified; FALS transgenic mice; anti SOD1 monoclonal antibody; neurodegenerative (Amyotrophic Lateral Sclerosis); paper does not mention ALZET much, or pump model..

15276 Jianfang Chen,, Eileen Marks, Barry Lai,, Zhaojie Zhang,, James A. Duce,, Linh Q. Lam,, Irene Volitakis,, Ashley I. Bush,, Steven Hersch,, Jonathan H. Fox  PLoS One 2013; 8(-10-):12. >>> deferoxamine; CSF/CNS (left lateral ventricle); mice; 1002; 6 wk old, R6/2 HD mice; neurodegenerative (Huntington's disease); dose: 1 nmole/hr.

15273 Hannah Botfield,, Ana Maria Gonzalez,, Osama Abdullah,, Anders Dæhli Skjolding,, Martin Berry,, James Pat McAllister II,, Ann Logan  Brain, A Journal of Neurology 2013; 136(--):2842-2858. >>> human recombinant decorin; PBS; CSF/CNS (right lateral ventricle); rat; 2002; MRI; controls received mp w/ vehicle; 3 wk old, Sprague-Dawley rats; dose: 5 mg/ml; mp were used to infuse decorin to suppress the inflammatory response in the subarachnoid space following a hemorrhage, and to prevent ventriculomegaly..

15237 Vaill, M.I., Desai, B.N., Harris, R.B.S. Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 306(-4-):E414-E423. >>> Leptin, rat recombinant; PBS; CSF/CNS (third ventricle); Rat; 1002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley); brain coordinates;.

15220 Koneru, B., Bathina, C.S., Cherry, B.H., Mifflin, S.W. Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2014; 306(-1-):R61-R66. >>> Aldosterone; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Animal info (Wistar-Kyoto, 275g); tissue perfusion (fourth ventricle); cardiovascular;.

15121 Trivedi, C., Shan, X.Y., Tung, Y.C.L., Kabra, D., Holland, J., Amburgy, S., Heppner, K., Kirchner, H., Yeo, G.S.H., Perez-Tilve, D., Perez-Tilve, D. Tachykinin-1 in the Central Nervous System Regulates Adiposity in Rodents. ENDOCRINOLOGY 2015; 156(--):1714-1723. >>> Ghrelin; neuropeptide K; Saline; CSF/CNS (fourth ventricle); CSF/CNS; Rat; mice; 1002;1007D; Controls received mp w/ vehicle; animal info (rat male, Wistar, 260-290g; mice male, C57Bl6, 12-16 weeks old); ALZET brain infusion kit used; dose-response (pg 1718); post op. care (analgesics); behavioral testing (locomotor activity); neuropeptide K aka NPK;.

15089 Stark, R., Reichenbach, A., Lockie, S.H., Pracht, C., Wu, Q.L., Tups, A., Andrews, Z.B., Andrews, Z.B. Acyl Ghrelin Acts in the Brain to Control Liver Function and Peripheral Glucose Homeostasis in Male Mice. ENDOCRINOLOGY 2015; 156(--):858-868. >>> Ghrelin, acyl; CSF, artificial; CSF/CNS (third ventricle); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6); ALZET brain infusion kit 3 used; tissue perfusion (third ventricle);.

15056 Pereira, L., Medina, R., Baena, M., Planas, A.M., Pozas, E., Pozas, E. IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche. Frontiers in Cellular Neuroscience 2015; 9(--):U1-U10. >>> Interferon, gamma; Saline; CSF/CNS (third ventricle); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, STAT2 KO or 129S6/SvEv); immunology;.

14921 do Carmo, J.M., da Silva, A.A., Hall, J.E., do Carmo, J.M. Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats. JOURNAL OF HYPERTENSION 2015; 33(--):1201-1206. >>> SHU-9119; CSF/CNS (fourth ventricle); Rat; 2002; Animal info (male, Spontaneously hypertensive or Wistar-Kyoto, 275-325g, 15-17 weeks old); behavioral testing (food intake); tissue perfusion (fourth ventricle); cardiovascular; Cannula placement verified via Evan's Blue dye; bp measured using radiotelemetry (DSI);.

14485 Wu, Y.W., Tu, Q.S., Valverde, P., Zhang, J., Murray, D., Dong, L.Q., Cheng, J., Jiang, H., Rios, M., Morgan, E., Tang, Z.H., Chen, J.K., Chen, J.K. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 306(--):E1418-E1430. >>> Adiponectin, globular; adiponectin, full-length; CSF, artificial; CSF/CNS (third ventricle); Mice; Controls received mp w/ vehicle; animal info (male, APN-KO or WT, 20-25g, 4-6 weeks old); ALZET brain infusion kit 2 used; tissue perfusion (third ventricle); cyanoacrylate adhesive; Cannula placement verified via micrograph imaging; used tygon tubing to attach BIK cannula to pump;.

14474 Wang, Y.K., Shen, D., Hao, Q., Yu, Q., Wu, Z.T., Deng, Y., Chen, Y.F., Yuan, W.J., Hu, Q.K., Su, D.F., Wang, W.Z., Wang, W.Z. Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 2014; 307(--):H182-H190. >>> A779; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, SHR and WKY); tissue perfusion (fourth ventricle);.

14429 Tan, M.S., Tan, L., Jiang, T., Zhu, X.C., Wang, H.F., Jia, C.D., Yu, J.T., Tan, L. Amyloid-beta induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease. Cell Death&Disease 2014; 5(--):U228-U239. >>> RNA, small interfering NLRP1; RNA, small interfering, NLRP3; RNA, small interfering caspase-1; CSF, artificial; water, RNase-free; CSF/CNS (dorsal third ventricle); Mice (transgenic); Controls received mp w/ vehicle or control RNA; animal info (male, APP/PS1); functionality of mp verified by knowckdown of targetd gene; ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); no stress"This dose of NLRP1 siRNA, caspase-1 siRNA or NLRP3 siRNA infusion was well tolerated, and no signs of neurotoxicity including hind-limb paralysis, vocalization, food intake, or neuroanatomical damage were observed in preliminary study."(see pg. 10); behavioral testing (morris water maze); tissue perfusion (dorsal third ventricle);"Our study using this approach of pump-mediated siRNA infusion is efficient in downregulation of NLRP1 mRNA (by about 60%) and protein (by about 50%) levels in APP/PS1 brain. And the treatment with control siRNA did not alter cerebral NLRP1 mRNA and protein levels compared with No siRNA-treated APP/PS1 mice, excluding an effect of pump-mediated infusion on NLRP1 expression levels."pg 8;.

14318 Neal-Perry, G., Yao, D.C., Shu, J., Sun, Y., Etgen, A.M., Neal-Perry, G. Insulin-Like Growth Factor-I Regulates LH Release by Modulation of Kisspeptin and NMDA-Mediated Neurotransmission in Young and Middle-Aged Female Rats. Endocrinology 2014; 155(--):1827-1837. >>> JB-1; insulin-like growth factor-1;; CSF, artificial; CSF/CNS (third ventricle); Rat; 2002; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 3-4 months or 9-11 months old, ovariectomized); peptides; cannula placement verified via dye infusion; used Plastics One cannula; JB-1 is a selective antagonist of IGF-Ir;.

14222 Hopp, S.C., D'Angelo, H.M., Royer, S.E., Kaercher, R.M., Crockett, A.M., Adzovic, L., Wenk, G.L., Wenk, G.L. Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U1-U14. >>> Endotoxin, LPS; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ aCSF; animal info (male F-344, 3 months old); neurodegenerative (Alzheimer's disease); behavioral testing (Morris Water Maze); immunology;.

14221 Hopp, S.C., Royer, S.E., D'Angelo, H.M., Kaercher, R.M., Fisher, D.A., Wenk, G.L., Wenk, G.L. Differential Neuroprotective and Anti-Inflammatory Effects of L-Type Voltage Dependent Calcium Channel and Ryanodine Receptor Antagonists in the Substantia Nigra and Locus Coeruleus. Journal of Neuroimmune Pharmacology 2015; 10(--):35-44. >>> Endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Animal info (male, F-344, 3 months old); behavioral testing (rotarod; open field test; forced swim test); tissue perfusion (fourth ventricle); immunology;.

14709 Desai, B.N., Harris, R.B.S., Harris, R.B.S. Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2015; 308(--):E351-E361. >>> Leptin; CSF/CNS (third ventricle; fourth ventricle); Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague Dawley, 275-300g); Multiple pumps per animal (2); tissue perfusion (third ventricle; fourth ventricle); bilateral infusion; one cannula to third ventricle second cannula to fourth ventricle; used plastics one cannula;.

14650 Adzovic, L., Lynn, A.E., D'Angelo, H.M., Crockett, A.M., Kaercher, R.M., Royer, S.E., Hopp, S.C., Wenk, G.L., Wenk, G.L. Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. Journal of Neuroinflammation 2015; 12(--):U1-U10. >>> Insulin, recombinant cat; endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (male, F-344, 3 months old, 21 months old); bilateral cannula used; behavioral testing (morris water maze); tissue perfusion (fourth ventricle); bilateral infusion; used tygon tubing to attach cannula to pump;.

14647 Van Kummer, B.H., Cohen, R.W., Cohen, R.W. Exercise-Induced Neuroprotection in the Spastic Han Wistar Rat: The Possible Role of Brain-Derived Neurotrophic Factor. BIOMED RESEARCH INTERNATIONAL 2015; ;(--):U1-U11. >>> K252a; DMSO; saline; CSF/CNS (third ventricle); Rat; 2004; Control animals received mp w/ vehicle; animal info (spastic, Han Wistar, 28 days old); 1% DMSO used.

14646 Tan, C.C., Zhang, J.G., Tan, M.S., Chen, H., Meng, D.W., Jiang, T., Meng, X.F., Li, Y., Sun, Z., Li, M.M., Yu, J.T., Tan, L., Yu, J.T. NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model. Journal of Neuroinflammation 2015; 12(--):U1-U12. >>> RNA, small interfering; CSF/CNS (third ventricle); Rat; 2006; Control animals received mp w/ control siRNA in aCSF; animal info (Sprague Dawley, 260-300 g); long-term study;.

14640 Meng, X.F., Tan, L., Tan, M.S., Jiang, T., Tan, C.C., Li, M.M., Wang, H.F., Yu, J.T., Tan, L. Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus. Journal of Neuroinflammation 2014; 11(--):U1-U12. >>> RNA, small interfering; CSF/CNS (third ventricle); Rat; 2006; Control animals received mp w/ aCSF; animal info (adult, male, Sprague Dawley, 260-300 g); long-term study;.

13856 Ma, J.H., Choi, B.R., Chung, C., Min, S.S., Jeon, W.K., Han, J.S., Han, J.S. Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus. MOLECULAR BRAIN 2014; 7(--):U1-U10. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Fischer-344); behavioral testing (morris water maze); tissue perfusion (fourth ventricle); immunology; LPS from E.coli, serotype 055:B5;.

13821 Jiang, T., Yu, J.T., Zhu, X.C., Tan, M.S., Gu, L.Z., Zhang, Y.D., Tan, L., Tan, L. Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. NEUROBIOLOGY OF AGING 2014; 35(--):1243-1251. >>> RNA, small interfering TREM2; Cerebrospinal fluid, artifical; CSF/CNS (dorsal third ventricle); Mice; 1004; Controls received mp w/ vehicle or control siRNA; animal info (SAMP8, 6 months old); functionality of mp verified by decrease TREM2 protein levels pg. 1246; ALZET brain infusion kit used; neurodegenerative (Alzheimers); no stress (see pg. 1244); behavioral testing (Morris water maze); tissue perfusion (third ventricle); immunology;.

13723 Brothers, H.M., Bardou, I., Hopp, S.C., Kaercher, R.M., Corona, A.W., Fenn, A.M., Godbout, J.P., Wenk, G.L. Riluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of Glutamate Transporters and Spatial Memory. Journal of Neuroimmune Pharmacology 2013; 8(-5-):1098-1105. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (Fisher F-344, 3 months old); behavioral testing (Morris water maze); tissue perfusion (fourth ventricle); immunology;.

13714 Bardou, I., Kaercher, R.M., Brothers, H.M., Hopp, S.C., Royer, S., Wenk, G.L. Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem. NEUROBIOLOGY OF AGING 2014; 35(-5-):1065-1073. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2006; Controls received mp w/ vehicle; animal info (male, F-344 rats, 3 months or 9 months or 23 months old); post op. care (lidocane 1% on wound; 2ML isotonic saline SC injection; 2% tylenol in drinking water 3 days after surgery); tissue perfusion (fourth ventricle); long-term study; immunology; LPS aka lipopolysaccharide;.

13711 Azzi, A., Dallmann, R., Casserly, A., Rehrauer, H., Patrignani, A., Maier, B., Kramer, A., Brown, S.A. Circadian behavior is light-reprogrammed by plastic DNA methylation. Nature Neuroscience 2014; 17(-3-):U62-U69. >>> Zebularine; Cerebrospinal fluid, artificial; DMSO; CSF/CNS (third ventricle); Mice; 1004; Controls received mp w/ vehicle; animal info (C57BL6J, 6 weeks old); behavioral testing (wheel-running behavior);"To ensure that we could reliably chronically infuse zebularine into the third ventricle in a way that pharmacologically influences the SCN, we performed a control experiment in which mice were chronically infused with TGFa for 7 d using ALZET osmotic mini pump model 1007D as described"Online methods pg1; Cannula placement verified via visual inspection; Zebularine is a cytidine analog and DNA methyltransferase inhibitor; circadian rhythm study;.

13669 Wu, Q., Zheng, R.M., Srisai, D., McKnight, G.S., Palmiter, R.D. NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2013; 110(-36-):14765-14770. >>> Lithium chloride; RO25-6981; bretazenil; Saline; CSF/CNS (fourth ventricle; parabrachial nucleus); Mice; 1002; Controls received mp w/ vehicle or sham surgery; animal info (male, Agrp DTR/+ or WT); bilateral cannula used; dose-response (pg.14766, fig.3; pg.14769, fig.6); behavioral testing (food intake); tissue perfusion (fourth ventricle; parabrachial nucleus); Cannula placement verified; RO25-6981 is a NR2B antagonist; bilateral infusion;.

13660 Tan, M.S., Yu, J.T., Jiang, T., Zhu, X.C., Guan, H.S., Tan, L. IL12/23 p40 Inhibition Ameliorates Alzheimer's Disease-Associated Neuropathology and Spatial Memory in SAMP8 Mice. JOURNAL OF ALZHEIMERS DISEASE 2014; 38(-3-):633-646. >>> RNA, small interfering p40; Cerebrospinal fluid, artificial; CSF/CNS (third ventricle); Mice; 1004; Controls received mp w/ control siRNA, aCSF, control antibody; animal info (male, SAMP8, SAMR1, 3 month, 7 month and 11 month old); functionality of mp verified by increased expression of IL-12 and IL-23; ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer); behavioral testing (Morris water maze);.

13655 Pandey, N.R., Zhou, X., Qin, Z.H., Zaman, T., Gomez-Smith, M., Keyhanian, K., Anisman, H., Brunel, J.M., Stewart, A.F.R., Chen, H.H. The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling. Journal of Neuroscience 2013; 33(-31-):12647-12655. >>> Leptin; Saline; CSF/CNS (third ventricle); Mice; Animal info (male, LMO4KO); behavioral testing (paired vs single feeding); diabetes; used guide cannula from Plastics One. used dental cement/screws.

13642 Howell, K.K., Monk, B.R., Carmack, S.A., Mrowczynski, O.D., Clark, R.E., Anagnostaras, S.G. Inhibition of PKC disrupts addiction-related memory. Frontiers in Behavioral Neuroscience 2014; 8(-;-):U1-U9. >>> Peptide, zeta-inhibitory; chelerythrine; Cerebrospinal fluid, artificial; PBS; CSF/CNS (third ventricle); Mice; 1002; Controls received mp w/ vehicle; animal info (C57BL/6Jx129T2SvEms/J, adult); ALZET brain infusion kit 3 used; post op. care (buprenorphine injection); behavioral testing (locomotion, locomotor sensitization); pulsatile delivery; dependence; peptides; zeta-inhibitory peptide aka ZIP; Lynch coil of ZIP administration for 14.5 hours; used mineral oil; Schematic of pump implantation pg.3 Fig 1A;.

 

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What researchers are saying...

“Mini-pumps were used to eliminate stress associated with multiple daily injections.” Akhter et al., Journal of Orthopaedic Research 2002;21:14-19.