References on the Intracerebroventricular Administration of Agents Using ALZET^® Osmotic Pumps

Q0870 Bai,Y.Y., Chang,F., Zhou,R., Jin,P.P., Matsumoto,H., Sokabe,M., Chen,L. Increase of Anteroventral Periventricular Kisspeptin Neurons and Generation of E2-Induced LH-Surge System in Male Rats Exposed Perinatally to Environmental Dose of Bisphenol-A. Endocrinology 2011; 152(-4-):1562-1571. >>> P234; NaCl; CSF/CNS; Rat; 2001; 15 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, adult, 200-250 g, PND35); P234 is a GPR54 antagonist.

Q0887 Barrera,J.G., Jones,K.R., Herman,J.P., D'Alessio,D.A., Woods,S.C., Seeley,R.J. Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function. Journal of Neuroscience 2011; 31(-10-):3904-3913. >>> Exendin (9-39); Saline; CSF/CNS; Rat; 2006; 2004; 4, 6 weeks; Controls received mp w/ vehicle; animal info (adult, male, Long-Evans); long-term study; Research Diets; obesity.

Q0862 Bonzon-Kulichenko,E., Fernandez-Agullo,T., Molto,E., Serrano,R., Fernandez,A., Ros,M., Carrascosa,J.M., Arribas,C., Martinez,C., Andres,A., Gallardo,N. Regulation of Insulin-Stimulated Glucose Uptake in Rat White Adipose Tissue upon Chronic Central Leptin Infusion: Effects on Adiposity. Endocrinology 2011; 152(-4-):1366-1377. >>> Leptin, rat; PBS; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 3-mo old); peptides.

Q0755 Crews,L., Patrick,C., Adame,A., Rockenstein,E., Masliah,E. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death&Disease 2011; 2(-;-):U24-U36. >>> Roscovitine; CSF/CNS; Mice; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (8 mo old, non tg, APP tg); cyanoacrylate adhesive.

Q0699 Gampe,K., Brill,M.S., Momma,S., Goetz,M., Zimmermann,H. EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles. Brain Research 2011; 1376(-;-):31-41. >>> Epidermal growth factor, recomb.; CSF, artificial; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; animal info (,ale, C57BL/6N, 8-10 wks old); artificial CSF formula.

Q0662 German,J.P., Thaler,J.P., Wisse,B.E., Oh,I., Sarruf,D.A., Matsen,M.E., Fischer,J.D., Taborsky,GJ Jr, Schwartz,M.W., Morton,G.J. Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia. Endocrinology 2011; 152(-2-):394-404. >>> Leptin; PBS; CSF/CNS; Rat; 11 days; Controls received mp w/ vehicle; animal info (adult, male, Wistar); peptides; pump implanted following 7-day recovery period after cannula insertion.

Q0674 Grobe,J.L., Buehrer,B.A., Hilzendeger,A.M., Liu,X.B., Davis,D.R., Xu,D., Sigmund,C.D. Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone (DOCA)-Salt in C57 Mice. Hypertension 2011; 57(-3-):600-607. >>> Losartan; angiotensin II; CSF, artificial; CSF/CNS; SC; Mice; ; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 6-8 wks old); peptides.

Q0806 Guggilam,A., Cardinale,J.P., Mariappan,N., Sriramula,S., Haque,M., Francis,J. Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide. Basic Research In Cardiology 2011; 106(-2-):273-286. >>> Etanercept; CSF, artificial; CSF/CNS; Mice; 1004; 4 weeks; Controls received mp w/ aCSF; animal info (male, TNF KO, myocardial infarction).

Q0905 Hansson,C., Haage,D., Taube,M., Egecioglu,E., Salome,N., Dickson,S.L. CENTRAL ADMINISTRATION OF GHRELIN ALTERS EMOTIONAL RESPONSES IN RATS: BEHAVIOURAL, ELECTROPHYSIOLOGICAL AND MOLECULAR EVIDENCE. Neuroscience 2011; 180(-;-):201-211. >>> Ghrelin; Saline; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 270-300 g); peptides; ALZET brain infusion kit 2 used.

Q0900 Jang,S., Kim,D., Lee,Y., Moon,S., Oh,S. Modulation of Sphingosine 1-Phosphate and Tyrosine Hydroxylase in the Stress-Induced Anxiety. Neurochemical Research 2011; 36(-2-):258-267. >>> Sphingosine 1-phosphate; CSF/CNS; Rat; 2ML1; 7 days; Controls received mp w/ saline; animal info (Sprague-Dawley, male, 260-280 g); pump implanted following 1 week recovery period after cannulation; PE-60 tubing used.

Q0645 Leong,S.Y., Faux,C.H., Turbic,A., Dixon,K.J., Turnley,A.M. The Rho Kinase Pathway Regulates Mouse Adult Neural Precursor Cell Migration. Stem Cells 2011; 29(-2-):332-343. >>> Uridine, bromodeoxy; Y27632; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ BrdU only; animal info (6-8 wks old, male, C57BL/6).

Q0891 MacMillan,K.S., Naidoo,J., Liang,J., Melito,L., Williams,N.S., Morlock,L., Huntington,P.J., Estill,S.J., Longgood,J., Becker,G.L., McKnight,S.L., Pieper,A.A., De Brabander,J.K., Ready,J.M. Development of Proneurogenic, Neuroprotective Small Molecules. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011; 133(-5-):1428-1437. >>> P7C3; analogue, P7C3; fibroblast growth factor-2; DMSO; cremophor EL; dextrose; water; CSF/CNS; Mice; 1007D; 7 days; Positive controls received mp w/ FGF-2; animal info (12 week old, C57BL/J6); neurodegenerative (Alzheimer's disease); 3% DMSO used.

Q0733 Murphy,K.J., Miller,A.M., Thelma,R., Cowley,F., Cox,F.F., Lynch,M.A. The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation. NEUROCHEMISTRY INTERNATIONAL 2011; 58(-2-):161-168. >>> Amyloid protein, beta (1-40); amyloid protein, beta (1-42); CSF/CNS; Rat; 2004; 8 days; Controls received mp w/ reverse peptide 40-1; animal info (Wistar, male, 3 mo old, 250-350 g, 22 mo old, 550-650 g); peptides; ALZET brain infusion kit II used.

Q0718 Petervari,E., Szabad,A.O., Soos,S., Garami,A., Szekely,M., Balasko,M. Central alpha-MSH infusion in rats: Disparate anorexic vs. metabolic changes with aging. REGULATORY PEPTIDES 2011; 166(-1-3-):105-111. >>> Melanocyte stimulating hormone, alpha; Saline, pyrogen free; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 2 mo, 3-4 mo, 12 mo, 24 mo old, ); ALZET brain infusion kit used; cannula placement verified macroscopically; 12 hour delayed delivery due to "dead-space of the connecting tube".

Q0642 Piccin,D., Morshead,C.M. Wnt Signaling Regulates Symmetry of Division of Neural Stem Cells in the Adult Brain and in Response to Injury. Stem Cells 2011; 29(-3-):528-538. >>> SB216763; secreted frizzled-related protein 2; Ara-C; DMSO; saline, sterile physiological; CSF/CNS; Mice; 1007D; 4, 6 days; Controls received mp w/ vehicle; animal info (BAT-gal, C57Bl/6, CD1, 8-12 wks old).

Q0656 Sabo,J.K., Aumann,T.D., Merlo,D., Kilpatrick,T.J., Cate,H.S. Remyelination Is Altered by Bone Morphogenic Protein Signaling in Demyelinated Lesions. Journal of Neuroscience 2011; 31(-12-):4504-4510. >>> BMP-4, recomb. human; noggin, mouse; CSF, artificial; CSF/CNS; Mice; 1002; 1007D; 14 days; Controls received mp w/ vehicle; animal info (adult, female, C57BL/6).

Q0651 Shioda,N., Beppu,H., Fukuda,T., Li,E., Kitajima,I., Fukunaga,K. Aberrant Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity Is Associated with Abnormal Dendritic Spine Morphology in the ATRX Mutant Mouse Brain. Journal of Neuroscience 2011; 31(-1-):346-358. >>> KN-93; Krebs-Ringer HEPES; CSF/CNS; Mice; 1004; 2 weeks; Controls received mp w/ vehicle; animal info (ATRX-delta E2, adult, 12 wks old, male); enzyme inhibitor (Calcium/Calmodulin-Dependent Protein Kinase II, CaMKII).

Q0636 Tsai,S.Y., Papadopoulos,C.M., Schwab,M.E., Kartje,G.L. Delayed Anti-Nogo-A Therapy Improves Function After Chronic Stroke in Adult Rats. Stroke 2011; 42(-1-):186-190. >>> Antibody, anti-Nogo-A; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/ inactive control antibody or no treatment; animal info (adult, male, Long Evans, black-hooded, 300 g); ischemia (stroke).

Q0714 Yau,J.L.W., Noble,J., Seckl,J.R. 11beta-Hydroxysteroid Dehydrogenase Type 1 Deficiency Prevents Memory Deficits with Aging by Switching from Glucocorticoid Receptor to Mineralocorticoid Receptor-Mediated Cognitive Control. Journal of Neuroscience 2011; 31(-11-):4188-4193. >>> Mifepristone; spironolactone; CSF, artificial; propylene glycol; CSF/CNS; 1002; 10 days; Controls received mp w/ vehicle; animal info (HSD1-/-, C57BL/6J, 24 mo old); post op. care (buprenorphine); memory.

Q0679 Zhu,D.L., Shi,J.P., Zhang,Y.D., Wang,B.R., Liu,W., Chen,Z.C., Tong,Q.A. Central Angiotensin II Stimulation Promotes beta Amyloid Production in Sprague Dawley Rats. PLoS One 2011; 6(-1-):U121-U129. >>> Angiotensin II; Saline, sterile; CSF/CNS; Rat; 2004; 1 week; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 280-310 g); peptides; ALZET brain infusion kit used.

Q0318 Abrams,J.M., Engeland,W.C., Osborn,J.W. Effect of intracerebroventricular benzamil on cardiovascular and central autonomic responses to DOCA-salt treatment. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 299(-6-):R1500-R1510. >>> Benzamil; CSF/CNS; Rat; 2004; 47 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 200-225 g); long-term study; ALZET brain infusion kit 2 used; pumps replaced on day 21; rate of rat cerebrospinal fluid production (3.7 +/- 0.1 ul/min) R1501..

Q0396 Agudo,M., Yip,P., Davies,M., Bradbury,E., Doherty,P., McMahon,S., Maden,M., Corcoran,J.P.T. A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. NEUROBIOLOGY OF DISEASE 2010; 37(-1-):147-155. >>> CD2019; CSF/CNS; Rat; ; Animal info (adult, dorsal column lesions, male); ALZET brain infusion kit used; CD2019 is a retinoic acid receptor beta agonist; 0.5 ul/hr, 14 day pump used.

Q0398 Alkadhi,K.A., Srivareerat,M., Tran,T.T. Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease. MOLECULAR AND CELLULAR NEUROSCIENCE 2010; 45(-3-):289-296. >>> Amyloid protein, beta (1-40); amyloid protein, beta 1-42; Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ amyloid protein beta non-pathogenic reverse peptide; animal info (adult, male, Wistar, 200-225 g); neurodegenerative (Alzheimer's disease).

Q0505 Amaral,F.A., Lemos,M.T.R., Dong,K.E., Bittencourt,M.F.Q.P., Caetano,A.L., Pesquero,J.B., Viel,T.A., Buck,H.S. Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-beta 1-40 peptide in mice. Neuropeptides 2010; 44(-2-):93-97. >>> Amyloid protein, beta (1-40); E-64; HEPES; CSF/CNS; Mice; 1004; 28 days; Controls received mp w/ vehicle; enzyme inhibitor (cystein protease); ALZET brain infusion kit 3 used; animal info (male, C57BL/6, wt, KOB1 KOB2, 28031 g, 12 wks old); behavioral testing (active avoidance); neurodegenerative (Alzheimer's Disease); "infusion (of beta-amyloid protein) could provide a tissue response closer to that observed in the pathogenesis of AD." pg 94.

Q0403 Beery,A.K., Zucker,I. OXYTOCIN AND SAME-SEX SOCIAL BEHAVIOR IN FEMALE MEADOW VOLES. Neuroscience 2010; 169(-2-):665-673. >>> Oxytocin antagonist; oxytocin; Saline; CSF/CNS; Prairie vole; 1007D; ; Controls received mp w/vehicle; animal info (female, 75-80 days old); plastics one cannula used; behavioral testing (same sex partner preference).

Q0883 Benoit,C.E., Bastianetto,S., Brouillette,J., Tse,Y., Boutin,J.A., Delagrange,P., Wong,T., Sarret,P., Quirion,R. Loss of Quinone Reductase 2 Function Selectively Facilitates Learning Behaviors. Journal of Neuroscience 2010; 30(-38-):12690-12700. >>> S26695; DMSO; saline; CSF/CNS; Rat; 2001; 1 week; Animal info (3-4 mo old); enzyme inhibitor (quinone reductase 2); behavioral testing (Morris maze test); 10% DMSO used.

Q0400 Bogaert,E., Van Damme,P., Poesen,K., Dhondt,J., Hersmus,N., Kiraly,D., Scheveneels,W., Robberecht,W., Van den Bosch,L. VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. NEUROBIOLOGY OF AGING 2010; 31(-12-):2185-2191. >>> Vascular endothelial growth factor; CSF/CNS; Rat; 2004; 1 week; Controls received mp w/ vehicle; animal info (80 days old).

Q0084 Crews,L., Spencer,B., Desplats,P., Patrick,C., Paulino,A., Rockenstein,E., Hansen,L., Adame,A., Galasko,D., Masliah,E. Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of alpha-Synucleinopathy. PLoS One 2010; 5(-2-):U163-U178. >>> Rapamycin; CSF/CNS; Mice; 1007D; 2 weeks; Controls received mp w/ vehicle; cyanoacrylate adhesive; animal info (alpha-syn, Tg); neurodegenerative (dementia with Lewy bodies, Parkinson's Disease).

P9966 Fang,P.C., Barbay,S., Plautz,E.J., Hoover,E., Strittmatter,S.M., Nudo,R.J. Combination of NEP 1-40 Treatment and Motor Training Enhances Behavioral Recovery After a Focal Cortical Infarct in Rats. Stroke 2010; 41(-3-):544-549. >>> NEP (1-40); PBS; DMSO; CSF/CNS; Rat; 2ML4; 28 days; ALZET brain infusion kit 2 used; animal info (Long Evans, adult, male); 2.5% DMSO used; cannula implanted first, pump implanted following recovery period of 7 days; behavioral testing (skilled reach test, motor trainning, foot faul test, cylinder test); NEP (1-40) also known as NOGO extracellular peptide.

Q0115 Garcia-Galiano,D., Navarro,V.M., Roa,J., Ruiz-Pino,F., Sanchez-Garrido,M.A., Pineda,R., Castellano,J.M., Romero,M., Aguilar,E., Gaytan,F., Dieguez,C., Pinilla,L., Tena-Sempere,M. The Anorexigenic Neuropeptide, Nesfatin-1, Is Indispensable for Normal Puberty Onset in the Female Rat. Journal of Neuroscience 2010; 30(-23-):7783-7792. >>> Oligonucleotide, antisense, morpholino; oligonucleotide, missense, morpholino; Saline; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ missense oligo; antisense (Nucleobindin 2); animal info (female, Wistar, 28 days old, adult); endocrinology.

P9896 Gillani,R.L., Tsai,S.Y., Wallace,D.G., O'Brien,T.E., Arhebamen,E., Tole,M., Schwab,M.E., Kartje,G.L. Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy. Behavioural Brain Research 2010; 208(-2-):415-424. >>> Antibody, anti-nogo-A; antibody, anti-wheat auxin; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/control antibody; animal info (male, Long Evans, black-headed, 18 mo old, MCAO).

Q0233 Gomez-Sanchez,E.P., Gomez-Sanchez,C.M., Plonczynski,M., Gomez-Sanchez,C.E. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Experimental Physiology 2010; 95(-1-):120-130. >>> FAD286; Propylene glycol; saline; CSF/CNS; Rat; 2004; ; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (Sprague Dawley, Dahl, salt sensitive); cannula placement verified post mortem with a dye.

Q0414 Hong,H.S., Maezawa,I., Budamagunta,M., Rana,S., Shi,A.B., Vassar,R., Liu,R.W., Lam,K.S., Cheng,R.H., Hua,D.H., Voss,J.C., Jin,L.W. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. NEUROBIOLOGY OF AGING 2010; 31(-10-):1690-1699. >>> K01-162; K01-182; DMSO; CSF, artificial; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (Tg6799 5xFAD, 3 months old); neurodegenerative (Alzheimer's disease); K01-162 and K01-186 are fluorene compounds from libraries of amyloid ligands.

Q0320 Huang,B.S., Ahmadi,S., Ahmad,M., White,R.A., Leenen,F.H.H. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-2-):U207-U215. >>> Angiotensin II; FAD-286; aldosterone, d-; Saline; CSF, artificial; ethanol; SC; CSF/CNS; Rat; 2001D; 2001; 2002; 2004; 2 weeks; 1, 4 days; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250 g); peptides; dose-response; enzyme inhibitor (aldosterone synthase); multiple pumps per animal (2); telemetry probe (model TA11PA-C40, DSI) used to measure BP and HR; 1% ethanol used with aldosterone.

Q0771 Huang,G.J., Smith,A.L., Gray,D.H.D., Cosgrove,C., Singer,B.H., Edwards,A., Sim,S., Parent,J.M., Johnsen,A., Mott,R., Mathis,D., Klenerman,P., Benoist,C., Flint,J. A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus. PLOS BIOLOGY 2010; 8(-12-):U107-U116. >>> Ganciclovir; CSF/CNS; Mice; 2004; 4 weeks; Animal info (GFAP-tk, nestin-tk); ALZET brain infusion kit 3 used.

Q0494 Ibi,D., Nitta,A., Ishige,K., Cen,X.B., Ohtakara,T., Nabeshima,T., Ito,Y. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. NEUROCHEMISTRY INTERNATIONAL 2010; 56(-1-):77-83. >>> Oligonucleotide, antisense; CSF/CNS; Mice; 1002; 7 days; Controls received mp w/ sense; antisense (piccolo); ALZET brain infusion kit 3 used; animal info (male, C57BL/6J, 8-10 wks old).

Q0241 Im,S.H., Yu,J.H., Park,E.S., Lee,J.E., Kim,H.O., Park,K.I., Kim,G.W., Park,C.I., Cho,S.R. INDUCTION OF STRIATAL NEUROGENESIS ENHANCES FUNCTIONAL RECOVERY IN AN ADULT ANIMAL MODEL OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY. Neuroscience 2010; 169(-1-):259-268. >>> Brain-derived neurotrophic factor; epidermal growth factor; ara-C; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/ PBS; ALZET brain infusion kit 3 used; animal info (ICR, 6 wks old); behavioral testing (rotarod performance, forelimb-use asymmetry test).

Q0124 Imayoshi,I., Sakamoto,M., Yamaguchi,M., Mori,K., Kageyama,R. Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains. Journal of Neuroscience 2010; 30(-9-):3489-3498. >>> Ara-C; Ringer's solution; albumin, mouse serum; CSF/CNS; Mice; 1002; 7 days; Animal info (C57BL/6:ICR, Rbpj-conditional mutant, 2 months old); cytosine-B-D-arabinofuranoside.

Q0598 Ittner,L.M., Ke,Y.D., Delerue,F., Bi,M.A., Gladbach,A., van Eersel,J., Woelfing,H., Chieng,B.C., Christie,M.J., Napier,I.A., Eckert,A., Staufenbiel,M., Hardeman,E., Goetz,J. Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell 2010; 142(-3-):387-397. >>> TAT-NR2B9c; CSF, artificial; CSF/CNS; Mice; 1004; 56 days; Negative controls received mp w/ Tat-NR2BAA; animal info (6 wks old, APP23, WT); long-term study; pumps replaced after 28 days; ALZET brain infusion kit 3 (with one spacer) used; peptides; neurodegenerative (Alzheimer's Disease).

Q0130 Iwasa,T., Matsuzaki,T., Murakami,M., Fujisawa,S., Kinouchi,R., Gereltsetseg,G., Kuwahara,A., Yasui,T., Irahara,M. Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats. JOURNAL OF PHYSIOLOGY-LONDON 2010; 588(-5-):821-829. >>> Kisspeptin-10; SC; CSF/CNS; Rat; 2002; 14 days; Animal info (prepubertal, P27, Sprague Dawley).

P9957 Jin,K.L., Wang,X.M., Xie,L., Mao,X.O., Greenberg,D.A. Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-17-):7993-7998. >>> Ganciclovir; CSF/CNS; Mice (transgenic); 1002; 14 days; Controls received mp w/ saline; animal info (DCX-Tk); incorrectly stated 1003D pumps used.

Q0128 Kinsey-Jones,J.S., Li,X.F., Knox,A.M.I., Lin,Y.S., Milligan,S.R., Lightman,S.L., O'Byrne,K.T. Corticotrophin-Releasing Factor Alters the Timing of Puberty in the Female Rat. Journal of Neuroendocrinology 2010; 22(-2-):102-109. >>> Corticotrophin-releasing factor; astressin-B; CSF, artificial; CSF/CNS; Rat; 2002; 14, 14 days; Controls received no treatment/surgery; peptides; no stress (see pg. 105); animal info (female, Sprague-Dawley, 28 days old); dose-response (fig. 1); neuroendocrinology.

P9991 Kishi,T., Hirooka,Y., Konno,S., Ogawa,K., Sunagawa,K. Angiotensin II Type 1 Receptor-Activated Caspase-3 Through Ras/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in the Rostral Ventrolateral Medulla Is Involved in Sympathoexcitation in Stroke-Prone Spontaneously Hypertensive Rats. Hypertension 2010; 55(-2-):291-297. >>> S-Farnesylthiosalicylic acid; Z-DEVD-FMK; candesartan; DMSO; CSF, artificial; CSF/CNS; Rat; 1003D; 14 days; Controls received mp w/ vehicle; animal info (WYKO, 14-16 wks old).

P9952 Koo,J.W., Russo,S.J., Ferguson,D., Nestler,E.J., Duman,R.S. Nuclear factor-kappa-B is a critical mediator of stress-impaired neurogenesis and depressive behavior. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-6-):2669-2674. >>> JSH-23; SC-514; DMSO; PBS; CSF/CNS; Rat; mice (transgenic); 1004; 2004; ; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (adult, male, Sprague Dawley, 230-250 g., NF-Kb/LacZ transgenic, wt, 20-30 g.); 50% DMSO used; 4-5 day delayed vehicle infusion to allow a recovery period; JSH-23 is a nuclear factor.

Q0138 Koyama,Y., Tanaka,K. Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroscience Letters 2010; 469(-3-):343-347. >>> Endothelin-1, ala-1, 3, 11, 15-; CSF, artificial; CSF/CNS; Rat; 2002; 3, 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, Wistar, 250-300 g.).

Q0157 Lazo,O.M., Mauna,J.C., Pissani,C.A., Inestrosa,N.C., Bronfman,F.C. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Molecular Neurodegeneration 2010; 5(-;-):U1-U12. >>> Nerve growth factor; CSF, artificial; CSF/CNS; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, 280-300 g.); aCSF recipe; incorrectly stated 2002 pump.

Q0135 Lecanu,L., Rammouz,G., McCourty,A., Sidahmed,E.K., Greeson,J., Papadopoulos,V. CAPROSPINOL REDUCES AMYLOID DEPOSITS AND IMPROVES COGNITIVE FUNCTION IN A RAT MODEL OF ALZHEIMER'S DISEASE. Neuroscience 2010; 165(-2-):427-435. >>> Amyloid protein, beta (1-42); buthionine suloximine; iron (II) sulfate; CSF/CNS; Rat; 2ML4; 8 weeks; Long-term study; pumps replaced after 4 weeks; animal info (Long Evans, 550 g); neurodegenerative (Alzheimer's Disease).

Q0021 Li,B., Piao,C.S., Liu,X.Y., Guo,W.P., Xue,Y.Q., Duan,W.M., Gonzalez-Toledo,M.E., Zhao,L.R. Brain self-protection: The role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Research 2010; 1327(-;-):91-102. >>> Ara-C; Saline; CSF/CNS; Mice; rat; 1007D; 7 days; Controls received mp w/vehicle; animal info (male, C57BL, 3 months old; male, SHR, 3-5 months old; CCAO, MCAO); ischemia (cerebral).

Q0948 Mak,G.K., Weiss,S. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nature Neuroscience 2010; 13(-6-):753-U134. >>> Prolactin, mouse, recomb.; luteinizing hormone, mouse, recomb.; antibody, prolactin neutralizing; Albumin, mouse, serum; PBS;; SC; CSF/CNS; Mice; 1003D; 1007D; 2 days; Controls received mp w/ vehicle or normal goat antibody; animal info (8 wks old, Prlr +/+, Prlr -/-, male).

Q0356 Menn,B., Bach,S., Blevins,T.L., Campbell,M., Meijer,L., Timsit,S. Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models. PLoS One 2010; 5(-8-):U113-U123. >>> Roscovitine, S-; DMSO; Krebs-Ringer's solution; CSF/CNS; SC; Rat; mice; 1003D; 48, 72 hours; Controls received mp w/ vehicle; animal info (P60, male, C57B/6, 20-25 g; P60, male, Sprague Dawley, 280-320 g); ischemia (cerebral).

P9990 Mercapide,J., Rappa,G., Anzanello,F., King,J., Fodstad,O., Lorico,A. Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma. International Journal of Cancer 2010; 126(-5-):1206-1215. >>> Cyclophosphamide; CSF/CNS; Mice (nude); ; Controls received mp w/ sterile saline; animal info (6 wks old, female).

Q0890 Mizuno,M., Iwakura,Y., Shibuya,M., Zheng,Y.J., Eda,T., Kato,T., Takasu,Y., Nawa,H. Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning. JOURNAL OF PHARMACOLOGICAL SCIENCES 2010; 114(-3-):320-331. >>> PD153035; ZD1839; OSI-774; DMSO; saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley); behavioral testing (locomotor activity test, acoustic startle test, contextual conditioning); 10% DMSO used; PD153035, OSI-774, and ZD1839 is an epidermal growth factor receptor family (ErbB1) inhibitor.

Q0163 Park,S., Ahn,I.S., Kim,D.S. Central infusion of leptin improves insulin resistance and suppresses beta-cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model. LIFE SCIENCES 2010; 86(-23-24-):854-862. >>> Leptin; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 223 g.); aCSF recipe; diabetes.

Q0420 Peng,S.C., Lai,Y.T., Huang,H.Y., Huang,H.D., Huang,Y.S. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. NUCLEIC ACIDS RESEARCH 2010; 38(-21-):7446-7457. >>> Endothelial growth factor, recomb.; gefitinib; DMSO; CSF, artificial; BSA; CSF/CNS; Mice; 1004; 14 days; Controls received mp w/ vehicle; animal info (8 wks old, male, C57BL/6J); behavioral testing (Morris water maze test); gefitinib is a chemotherapeutic.

Q0246 Petervari,E., Garami,A., Soos,S., Szekely,M., Balasko,M. Age-dependence of alpha-MSH-induced anorexia. Neuropeptides 2010; 44(-4-):315-322. >>> Melanocyte stimulating hormone, alpha; Saline, pyrogen free; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; ALZET brain infusion kit used; animal info (male, Wistar, 6-9 wks old, 3-4, 6, 12, 18, 24 mo old).

Q0180 Pierce,A.A., Xu,A.W. De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance. Journal of Neuroscience 2010; 30(-2-):723-730. >>> Ara-C; uridine, 5' bromodeoxy; CSF, artificial; BSA; CSF/CNS; Mice (transgenic); 2006; 4, 6 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit; animal info (male, wt, AgRP-Tfam, 12 weeks old); functionality of mp verified by residual volume; cannula placement confirmed histologically.

Q0080 Pineda,R., Garcia-Galiano,D., Roseweir,A., Romero,M., Sanchez-Garrido,M.A., Ruiz-Pino,F., Morgan,K., Pinilla,L., Millar,R.P., Tena-Sempere,M. Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist. Endocrinology 2010; 151(-2-):722-730. >>> P234; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (prepubertal, female, adult, cyclic); P234 is a kisspeptin antagonist.

Q0355 Pinnock,S.B., Blake,A.M., Platt,N.J., Herbert,J. The Roles of BDNF, pCREB and Wnt3a in the Latent Period Preceding Activation of Progenitor Cell Mitosis in The Adult Dentate Gyrus by Fluoxetine. PLoS One 2010; 5(-10-):U236-U243. >>> K252a; fluoxetine; Saline; CSF/CNS; SC; Rat; 1002; 2ML2; 7, 14 days; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 8 wks old, 200-250 g); multiple pumps per animal (2); cannula placement verified by examining its track on sections stained with cresyl violet.

Q0408 Ryu,H.J., Kim,J.E., Kim,M.J., Kwon,H.J., Suh,S.W., Song,H.K., Kang,T.C. THE PROTECTIVE EFFECTS OF INTERLEUKIN-18 AND INTERFERON-gamma ON NEURONAL DAMAGES IN THE RAT HIPPOCAMPUS FOLLOWING STATUS EPILEPTICUS. Neuroscience 2010; 170(-3-):711-721. >>> Antibody, anti IL-18; IL-18, recomb. rat; interferon, gamma, recomb. rat; antibody, anti interferon, gamma; IL-18 receptor antagonist; interferon, gamma, receptor antagonist; Saline; CSF/CNS; Rat; 1007D; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 7 wks old); ALZET brain infusion kit 1 used.

Q0185 Sangiao-Alvarellos,S., Varela,L., Vazquez,M.J., Da Boit,K., Saha,A.K., Cordido,F., Dieguez,C., Lopez,M. Influence of Ghrelin and Growth Hormone Deficiency on AMP-Activated Protein Kinase and Hypothalamic Lipid Metabolism. Journal of Neuroendocrinology 2010; 22(-6-):543-556. >>> Ghrelin, acyl; Saline; CSF/CNS; Rat; 2001; 2ML2; 8 days; Controls received mp w/ vehicle; peptides; animal info (male, Lewis, wt, GH deficient (dwarf), 2-3 months old, 365 g, 222 g); cannula placement confirmed by methylene blue staining; endocrinology.

Q0106 Sarruf,D.A., Thaler,J.P., Morton,G.J., German,J., Fischer,J.D., Ogimoto,K., Schwartz,M.W. Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats. Diabetes 2010; 59(-7-):1817-1824. >>> Fibroblast growth factor-21, recomb. human; BSA; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (male, Wistar, 250-275 g); Research diets D12492; diabetes.

Q0057 Selvamani,A., Sohrabji,F. The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1. Journal of Neuroscience 2010; 30(-20-):6852-6861. >>> Insulin-like growth factor-1; JB-1; CSF, artificial; CSF/CNS; Rat (pregnant); 1007D; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; cyanoacrylate adhesive; animal info (virgin, 3-4 months old, pregnant, 5-6 months old, retired, 9-11 months old); MCAO.

Q0066 Shi,P., ez-Freire,C., Jun,J.Y., Qi,Y.F., Katovich,M.J., Li,Q.H., Sriramula,S., Francis,J., Sumners,C., Raizada,M.K. Brain Microglial Cytokines in Neurogenic Hypertension. Hypertension 2010; 56(-2-):297-303. >>> Minocycline; angiotensin II; SC; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ saline; ALZET brain infusion kit used; multiple pumps per animal (2); post op. care (buprenorphine); animal info (male, Sprague Dawley, 6 wks old).

Q0252 Shinohara,M., Sato,N., Kurinami,H., Takeuchi,D., Takeda,S., Shimamura,M., Yamashita,T., Uchiyama,Y., Rakugi,H., Morishita,R. Reduction of Brain beta-Amyloid (A-beta) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and A-beta Clearance. Journal of Biological Chemistry 2010; 285(-29-):22091-22102. >>> Leupeptin; E-64a; CSF, artificial; CSF/CNS; Mice (transgenic); 2002; 1 week; Controls received mp w/ vehicle; peptides; ALZET brain infusion kit 3 used; no stress (see pg 22092); neurodegenerative (Alzheimer's Disease); animal info (male, C57BL/6, APP23 Tg, 8 wks old); Lysosomal inhibitor; aCSF recipe.

Q0244 Slattery,D.A., Neumann,I.D. Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats. Neuropharmacology 2010; 58(-1-):56-61. >>> Oxytocin; oxytocin receptor antagonist; Ringer's solution; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, female, HAB, LAB, Wistar, 250-350 g.); behavioral testing (light-dark box, elevated plus-maze, forced swim test); cannula placement verified post mortem by injecting blue dye into the cannula.

Q0813 Sugaya,Y., Maru,E., Kudo,K., Shibasaki,T., Kato,N. Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus. Brain Research 2010; 1352(-;-):187-199. >>> Levetiracetam; Saline; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 8 wks old); 15 ul saline allowed for 3-day delayed delivery followed by 25-day levetiracetam delivery; "A preliminary study in which a mini-pump was filled with bromophenol blue instead of levetiracetam, confirmed that the pumped drug solution was constantly separated from the predrug saline for 3 days at 37°C." pg 196.

P9988 Sultan,S., Mandairon,N., Kermen,F., Garcia,S., Sacquet,J., Didier,A. Learning-dependent neurogenesis in the olfactory bulb determines long-term olfactory memory. FASEB Journal 2010; 24(-7-):2355-2363. >>> Ara-C; Saline; CSF/CNS; Mice; 2004; ; Controls received mp w/ vehicle; animal info (adult, C57BL/6).

Q0099 Thakker-Varia,S., Jean,Y.Y., Parikh,P., Sizer,C.F., Ayer,J.J., Parikh,A., Hyde,T.M., Buyske,S., Alder,J. The Neuropeptide VGF Is Reduced in Human Bipolar Postmortem Brain and Contributes to Some of the Behavioral and Molecular Effects of Lithium. Journal of Neuroscience 2010; 30(-28-):9368-9380. >>> TLQP-62 C-terminal amidated peptide; CSF/CNS; Mice; 2004; 21 days; Controls received mp w/ saline; ALZET brain infusion kit 3 used; cyanoacrylate adhesive; animal info (adult, 3-4 months old, male, 30 g); cannula placement verified post mortem via cryostat sections; compound also known as vascular endothelial growth factor.

Q0339 Theus,M.H., Ricard,J., Bethea,J.R., Liebl,D.J. EphB3 Limits the Expansion of Neural Progenitor Cells in the Subventricular Zone by Regulating p53 During Homeostasis and Following Traumatic Brain Injury. Stem Cells 2010; 28(-7-):1231-1242. >>> Ephrin B3-Fc; CSF/CNS; Mice; 1007D; 3 days; Controls received mp w/ Human Fc control; animal info (male, 2-4 months old, mutant CD1, ephrinB3 -/-, Eph3 -/-, CCI injured).

Q0500 Tran,T.T., Srivareerat,M., Alkadhi,K.A. Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease. NEUROBIOLOGY OF DISEASE 2010; 37(-3-):756-763. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ amyloid protein beta (42-1); peptides; animal info (Wistar, 200-225 g); 14-day pump used; neurodegenerative (Alzheimer's Disease).

Q0060 Tschoep,J., Nogueiras,R., Haas-Lockie,S., Kasten,K.R., Castaneda,T.R., Huber,N., Guanciale,K., Perez-Tilve,D., Habegger,K., Ottaway,N., Woods,S.C., Oldfield,B., Clarke,I., Chua,S Jr, Farooqi,I.S., O'Rahilly,S., Caldwell,C.C., Tschoep,M.H. CNS Leptin Action Modulates Immune Response and Survival in Sepsis. Journal of Neuroscience 2010; 30(-17-):6036-6047. >>> Leptin; Saline, isotonic; SC; CSF/CNS; Mice; 1003D; 14 days; Controls received mp w/ vehicle; cyanoacrylate adhesive; ALZET brain infusion kit 3 used; animal info (male, ob/ob, wt, 8-10 wks old); post op. care (buprenorphine).

Q0059 Ubhi,K., Rockenstein,E., Mante,M., Inglis,C., Adame,A., Patrick,C., Whitney,K., Masliah,E. Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors. Journal of Neuroscience 2010; 30(-18-):6236-6246. >>> Glial-derived neurotrophic factor; CSF/CNS; Mice; 1002; 14 days; Animal info (MBP-h alpha syn Tg, 8 months old).

Q0242 Van Kampen,J.M., Eckman,C.B. Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation. Neuropharmacology 2010; 58(-6-):921-929. >>> Physostigmine; carbachol; nicotine; pirenzepine; oxotremorine; mecamylamine; Saline; CSF/CNS; Rat; 2002; 2004; ; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250 g.); neurodegenerative (Alzheimer's Disease).

Q0089 Veeravalli,K.K., Chetty,C., Ponnala,S., Gondi,C.S., Lakka,S.S., Fassett,D., Klopfenstein,J.D., Dinh,D.H., Gujrati,M., Rao,J.S. MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice. PLoS One 2010; 5(-7-):U28-U42. >>> MMP-9; uPAR; cathepsin B; CSF/CNS; Mice; ; Pump infused at a rate of 0.2 u/hr.

Q0471 Verty,A.N.A., Allen,A.M., Oldfield,B.J. The Endogenous Actions of Hypothalamic Peptides on Brown Adipose Tissue Thermogenesis in the Rat. Endocrinology 2010; 151(-9-):4236-4246. >>> SB-334867-A; SNAP-7941; SHU9119; Cyclodextrin, beta hydroxypropyl; DMSO; water, sterile; saline, physiological; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle; animal info (naïve, male, Sprague Dawley, 8 wks old, 200-300 g); 3-day delayed CNS infusion by filling tygon tubing with 40 ul of saline; cannula placement verified post mortem with cresyl violet staining; guide cannula used; obesity; endocrinology.

Q0837 Warner-Schmidt,J.L., Chen,E.Y., Zhang,X.Q., Marshall,J.J., Morozov,A., Svenningsson,P., Greengard,P. A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor. Biological Psychiatry 2010; 68(-6-):528-535. >>> Brain-derived neurotrophic factor, recomb.; CSF/CNS; Mice (transgenic); 1003D; 3 days; Animal info (8-10 wks old, C57BL/6, BDNF Tg); behavioral testing (tail suspension test, forced swim test, open field locomotor activity); Plastics One cannula used.

P9886 Wernicke,C., Hellmann,J., Zieba,B., Kuter,K., Ossowska,K., Frenzel,M., Dencher,N.A., Rommelspacher,H. 9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease. Pharmacological Reports 2010; 62(-1-):35-53. >>> MPP+; Saline; CSF/CNS; Rat; 2ML4; 42 days; Controls received mp w/vehicle or sham operation; long term study; animal info (male, wistar, 280-300 g).

Q0259 Yaguchi,T., Nagata,T., Yang,D.Q., Nishizaki,T. Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity. Behavioural Brain Research 2010; 206(-1-):47-51. >>> Interleukin-18; CSF/CNS; Mice; 1007D; 4 days; Controls received mp w/ serum; animal info (wt, IL-18 KO); behavioral testing (water maze test).

Q0412 Yamauchi,T., Tatsumi,K., Makinodan,M., Kimoto,S., Toritsuka,M., Okuda,H., Kishimoto,T., Wanaka,A. Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus. NEUROCHEMISTRY INTERNATIONAL 2010; 57(-5-):565-571. >>> Ara-C; CSF/CNS; Mice; 1002; 4 weeks; Controls received mp w/aCSF; animal info (Female C57BL/6J, 10 wks old); pumps replaced after 2 weeks; ALZET brain infusion kit 3 used; 2-day delayed infusion by filling vinyl tubing with artificial CSF.

Q0064 Yin,K.J., Deng,Z., Hamblin,M., Xiang,Y., Huang,H.R., Zhang,J.F., Jiang,X.D., Wang,Y.Z., Chen,Y.E. Peroxisome Proliferator-Activated Receptor-delta Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury. Journal of Neuroscience 2010; 30(-18-):6398-6408. >>> GW501516; CSF/CNS; Mice; 1003D; ; Controls received mp w/ vehicle; ischemia (cerebral).

Q0497 Yin,K.J., Deng,Z., Huang,H.R., Hamblin,M., Xie,C.Q., Zhang,J.F., Chen,Y.E. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. NEUROBIOLOGY OF DISEASE 2010; 38(-1-):17-26. >>> Oligonucleotide, antisense; CSF, artificial; CSF/CNS; Mice; 1003D; ; Negative controls received mp w/ miR-antagomir negative control or artificial CSF; antisense (miR-497); animal info (male, C57/Bl6); ischemia (focal cerebral).

Q0880 Zhu,X.H., Yan,H.C., Zhang,J., Qu,H.D., Qiu,X.S., Chen,L.A., Li,S.J., Cao,X.O., Bean,J.C., Chen,L.H., Qin,X.H., Liu,J.H., Bai,X.C., Mei,L., Gao,T.M. Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats. Journal of Neuroscience 2010; 30(-38-):12653-12663. >>> K252a; antibody, chicken anti-BDNF; antibody, chicken IgY; CSF, artificial; DMSO; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (3 mo old, Sprague Dawley, 180-220 g, male); 50% DMSO used; depression.