References on the Intracerebroventricular Administration of Agents to Mice Using ALZET^® Osmotic Pumps

Q0755 Crews,L., Patrick,C., Adame,A., Rockenstein,E., Masliah,E. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death&Disease 2011; 2(-;-):U24-U36. >>> Roscovitine; CSF/CNS; Mice; 1007D; 2 weeks; Controls received mp w/ vehicle; animal info (8 mo old, non tg, APP tg); cyanoacrylate adhesive.

Q0699 Gampe,K., Brill,M.S., Momma,S., Goetz,M., Zimmermann,H. EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles. Brain Research 2011; 1376(-;-):31-41. >>> Epidermal growth factor, recomb.; CSF, artificial; CSF/CNS; Mice; 1007D; 6 days; Controls received mp w/ vehicle; animal info (,ale, C57BL/6N, 8-10 wks old); artificial CSF formula.

Q0674 Grobe,J.L., Buehrer,B.A., Hilzendeger,A.M., Liu,X.B., Davis,D.R., Xu,D., Sigmund,C.D. Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone (DOCA)-Salt in C57 Mice. Hypertension 2011; 57(-3-):600-607. >>> Losartan; angiotensin II; CSF, artificial; CSF/CNS; SC; Mice; ; Controls received mp w/ vehicle; animal info (male, C57BL/6J, 6-8 wks old); peptides.

Q0806 Guggilam,A., Cardinale,J.P., Mariappan,N., Sriramula,S., Haque,M., Francis,J. Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide. Basic Research In Cardiology 2011; 106(-2-):273-286. >>> Etanercept; CSF, artificial; CSF/CNS; Mice; 1004; 4 weeks; Controls received mp w/ aCSF; animal info (male, TNF KO, myocardial infarction).

Q0645 Leong,S.Y., Faux,C.H., Turbic,A., Dixon,K.J., Turnley,A.M. The Rho Kinase Pathway Regulates Mouse Adult Neural Precursor Cell Migration. Stem Cells 2011; 29(-2-):332-343. >>> Uridine, bromodeoxy; Y27632; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ BrdU only; animal info (6-8 wks old, male, C57BL/6).

Q0891 MacMillan,K.S., Naidoo,J., Liang,J., Melito,L., Williams,N.S., Morlock,L., Huntington,P.J., Estill,S.J., Longgood,J., Becker,G.L., McKnight,S.L., Pieper,A.A., De Brabander,J.K., Ready,J.M. Development of Proneurogenic, Neuroprotective Small Molecules. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011; 133(-5-):1428-1437. >>> P7C3; analogue, P7C3; fibroblast growth factor-2; DMSO; cremophor EL; dextrose; water; CSF/CNS; Mice; 1007D; 7 days; Positive controls received mp w/ FGF-2; animal info (12 week old, C57BL/J6); neurodegenerative (Alzheimer's disease); 3% DMSO used.

Q0642 Piccin,D., Morshead,C.M. Wnt Signaling Regulates Symmetry of Division of Neural Stem Cells in the Adult Brain and in Response to Injury. Stem Cells 2011; 29(-3-):528-538. >>> SB216763; secreted frizzled-related protein 2; Ara-C; DMSO; saline, sterile physiological; CSF/CNS; Mice; 1007D; 4, 6 days; Controls received mp w/ vehicle; animal info (BAT-gal, C57Bl/6, CD1, 8-12 wks old).

Q0656 Sabo,J.K., Aumann,T.D., Merlo,D., Kilpatrick,T.J., Cate,H.S. Remyelination Is Altered by Bone Morphogenic Protein Signaling in Demyelinated Lesions. Journal of Neuroscience 2011; 31(-12-):4504-4510. >>> BMP-4, recomb. human; noggin, mouse; CSF, artificial; CSF/CNS; Mice; 1002; 1007D; 14 days; Controls received mp w/ vehicle; animal info (adult, female, C57BL/6).

Q0651 Shioda,N., Beppu,H., Fukuda,T., Li,E., Kitajima,I., Fukunaga,K. Aberrant Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity Is Associated with Abnormal Dendritic Spine Morphology in the ATRX Mutant Mouse Brain. Journal of Neuroscience 2011; 31(-1-):346-358. >>> KN-93; Krebs-Ringer HEPES; CSF/CNS; Mice; 1004; 2 weeks; Controls received mp w/ vehicle; animal info (ATRX-delta E2, adult, 12 wks old, male); enzyme inhibitor (Calcium/Calmodulin-Dependent Protein Kinase II, CaMKII).

Q0505 Amaral,F.A., Lemos,M.T.R., Dong,K.E., Bittencourt,M.F.Q.P., Caetano,A.L., Pesquero,J.B., Viel,T.A., Buck,H.S. Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-beta 1-40 peptide in mice. Neuropeptides 2010; 44(-2-):93-97. >>> Amyloid protein, beta (1-40); E-64; HEPES; CSF/CNS; Mice; 1004; 28 days; Controls received mp w/ vehicle; enzyme inhibitor (cystein protease); ALZET brain infusion kit 3 used; animal info (male, C57BL/6, wt, KOB1 KOB2, 28031 g, 12 wks old); behavioral testing (active avoidance); neurodegenerative (Alzheimer's Disease); "infusion (of beta-amyloid protein) could provide a tissue response closer to that observed in the pathogenesis of AD." pg 94.

Q0084 Crews,L., Spencer,B., Desplats,P., Patrick,C., Paulino,A., Rockenstein,E., Hansen,L., Adame,A., Galasko,D., Masliah,E. Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of alpha-Synucleinopathy. PLoS One 2010; 5(-2-):U163-U178. >>> Rapamycin; CSF/CNS; Mice; 1007D; 2 weeks; Controls received mp w/ vehicle; cyanoacrylate adhesive; animal info (alpha-syn, Tg); neurodegenerative (dementia with Lewy bodies, Parkinson's Disease).

Q0414 Hong,H.S., Maezawa,I., Budamagunta,M., Rana,S., Shi,A.B., Vassar,R., Liu,R.W., Lam,K.S., Cheng,R.H., Hua,D.H., Voss,J.C., Jin,L.W. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. NEUROBIOLOGY OF AGING 2010; 31(-10-):1690-1699. >>> K01-162; K01-182; DMSO; CSF, artificial; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/ vehicle; animal info (Tg6799 5xFAD, 3 months old); neurodegenerative (Alzheimer's disease); K01-162 and K01-186 are fluorene compounds from libraries of amyloid ligands.

Q0771 Huang,G.J., Smith,A.L., Gray,D.H.D., Cosgrove,C., Singer,B.H., Edwards,A., Sim,S., Parent,J.M., Johnsen,A., Mott,R., Mathis,D., Klenerman,P., Benoist,C., Flint,J. A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus. PLOS BIOLOGY 2010; 8(-12-):U107-U116. >>> Ganciclovir; CSF/CNS; Mice; 2004; 4 weeks; Animal info (GFAP-tk, nestin-tk); ALZET brain infusion kit 3 used.

Q0494 Ibi,D., Nitta,A., Ishige,K., Cen,X.B., Ohtakara,T., Nabeshima,T., Ito,Y. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. NEUROCHEMISTRY INTERNATIONAL 2010; 56(-1-):77-83. >>> Oligonucleotide, antisense; CSF/CNS; Mice; 1002; 7 days; Controls received mp w/ sense; antisense (piccolo); ALZET brain infusion kit 3 used; animal info (male, C57BL/6J, 8-10 wks old).

Q0241 Im,S.H., Yu,J.H., Park,E.S., Lee,J.E., Kim,H.O., Park,K.I., Kim,G.W., Park,C.I., Cho,S.R. INDUCTION OF STRIATAL NEUROGENESIS ENHANCES FUNCTIONAL RECOVERY IN AN ADULT ANIMAL MODEL OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY. Neuroscience 2010; 169(-1-):259-268. >>> Brain-derived neurotrophic factor; epidermal growth factor; ara-C; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/ PBS; ALZET brain infusion kit 3 used; animal info (ICR, 6 wks old); behavioral testing (rotarod performance, forelimb-use asymmetry test).

Q0124 Imayoshi,I., Sakamoto,M., Yamaguchi,M., Mori,K., Kageyama,R. Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains. Journal of Neuroscience 2010; 30(-9-):3489-3498. >>> Ara-C; Ringer's solution; albumin, mouse serum; CSF/CNS; Mice; 1002; 7 days; Animal info (C57BL/6:ICR, Rbpj-conditional mutant, 2 months old); cytosine-B-D-arabinofuranoside.

Q0598 Ittner,L.M., Ke,Y.D., Delerue,F., Bi,M.A., Gladbach,A., van Eersel,J., Woelfing,H., Chieng,B.C., Christie,M.J., Napier,I.A., Eckert,A., Staufenbiel,M., Hardeman,E., Goetz,J. Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell 2010; 142(-3-):387-397. >>> TAT-NR2B9c; CSF, artificial; CSF/CNS; Mice; 1004; 56 days; Negative controls received mp w/ Tat-NR2BAA; animal info (6 wks old, APP23, WT); long-term study; pumps replaced after 28 days; ALZET brain infusion kit 3 (with one spacer) used; peptides; neurodegenerative (Alzheimer's Disease).

P9957 Jin,K.L., Wang,X.M., Xie,L., Mao,X.O., Greenberg,D.A. Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-17-):7993-7998. >>> Ganciclovir; CSF/CNS; Mice (transgenic); 1002; 14 days; Controls received mp w/ saline; animal info (DCX-Tk); incorrectly stated 1003D pumps used.

P9952 Koo,J.W., Russo,S.J., Ferguson,D., Nestler,E.J., Duman,R.S. Nuclear factor-kappa-B is a critical mediator of stress-impaired neurogenesis and depressive behavior. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-6-):2669-2674. >>> JSH-23; SC-514; DMSO; PBS; CSF/CNS; Rat; mice (transgenic); 1004; 2004; ; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (adult, male, Sprague Dawley, 230-250 g., NF-Kb/LacZ transgenic, wt, 20-30 g.); 50% DMSO used; 4-5 day delayed vehicle infusion to allow a recovery period; JSH-23 is a nuclear factor.

Q0021 Li,B., Piao,C.S., Liu,X.Y., Guo,W.P., Xue,Y.Q., Duan,W.M., Gonzalez-Toledo,M.E., Zhao,L.R. Brain self-protection: The role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Research 2010; 1327(-;-):91-102. >>> Ara-C; Saline; CSF/CNS; Mice; rat; 1007D; 7 days; Controls received mp w/vehicle; animal info (male, C57BL, 3 months old; male, SHR, 3-5 months old; CCAO, MCAO); ischemia (cerebral).

Q0948 Mak,G.K., Weiss,S. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nature Neuroscience 2010; 13(-6-):753-U134. >>> Prolactin, mouse, recomb.; luteinizing hormone, mouse, recomb.; antibody, prolactin neutralizing; Albumin, mouse, serum; PBS;; SC; CSF/CNS; Mice; 1003D; 1007D; 2 days; Controls received mp w/ vehicle or normal goat antibody; animal info (8 wks old, Prlr +/+, Prlr -/-, male).

Q0356 Menn,B., Bach,S., Blevins,T.L., Campbell,M., Meijer,L., Timsit,S. Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models. PLoS One 2010; 5(-8-):U113-U123. >>> Roscovitine, S-; DMSO; Krebs-Ringer's solution; CSF/CNS; SC; Rat; mice; 1003D; 48, 72 hours; Controls received mp w/ vehicle; animal info (P60, male, C57B/6, 20-25 g; P60, male, Sprague Dawley, 280-320 g); ischemia (cerebral).

P9990 Mercapide,J., Rappa,G., Anzanello,F., King,J., Fodstad,O., Lorico,A. Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma. International Journal of Cancer 2010; 126(-5-):1206-1215. >>> Cyclophosphamide; CSF/CNS; Mice (nude); ; Controls received mp w/ sterile saline; animal info (6 wks old, female).

Q0420 Peng,S.C., Lai,Y.T., Huang,H.Y., Huang,H.D., Huang,Y.S. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. NUCLEIC ACIDS RESEARCH 2010; 38(-21-):7446-7457. >>> Endothelial growth factor, recomb.; gefitinib; DMSO; CSF, artificial; BSA; CSF/CNS; Mice; 1004; 14 days; Controls received mp w/ vehicle; animal info (8 wks old, male, C57BL/6J); behavioral testing (Morris water maze test); gefitinib is a chemotherapeutic.

Q0180 Pierce,A.A., Xu,A.W. De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance. Journal of Neuroscience 2010; 30(-2-):723-730. >>> Ara-C; uridine, 5' bromodeoxy; CSF, artificial; BSA; CSF/CNS; Mice (transgenic); 2006; 4, 6 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit; animal info (male, wt, AgRP-Tfam, 12 weeks old); functionality of mp verified by residual volume; cannula placement confirmed histologically.

Q0252 Shinohara,M., Sato,N., Kurinami,H., Takeuchi,D., Takeda,S., Shimamura,M., Yamashita,T., Uchiyama,Y., Rakugi,H., Morishita,R. Reduction of Brain beta-Amyloid (A-beta) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and A-beta Clearance. Journal of Biological Chemistry 2010; 285(-29-):22091-22102. >>> Leupeptin; E-64a; CSF, artificial; CSF/CNS; Mice (transgenic); 2002; 1 week; Controls received mp w/ vehicle; peptides; ALZET brain infusion kit 3 used; no stress (see pg 22092); neurodegenerative (Alzheimer's Disease); animal info (male, C57BL/6, APP23 Tg, 8 wks old); Lysosomal inhibitor; aCSF recipe.

P9988 Sultan,S., Mandairon,N., Kermen,F., Garcia,S., Sacquet,J., Didier,A. Learning-dependent neurogenesis in the olfactory bulb determines long-term olfactory memory. FASEB Journal 2010; 24(-7-):2355-2363. >>> Ara-C; Saline; CSF/CNS; Mice; 2004; ; Controls received mp w/ vehicle; animal info (adult, C57BL/6).

Q0099 Thakker-Varia,S., Jean,Y.Y., Parikh,P., Sizer,C.F., Ayer,J.J., Parikh,A., Hyde,T.M., Buyske,S., Alder,J. The Neuropeptide VGF Is Reduced in Human Bipolar Postmortem Brain and Contributes to Some of the Behavioral and Molecular Effects of Lithium. Journal of Neuroscience 2010; 30(-28-):9368-9380. >>> TLQP-62 C-terminal amidated peptide; CSF/CNS; Mice; 2004; 21 days; Controls received mp w/ saline; ALZET brain infusion kit 3 used; cyanoacrylate adhesive; animal info (adult, 3-4 months old, male, 30 g); cannula placement verified post mortem via cryostat sections; compound also known as vascular endothelial growth factor.

Q0339 Theus,M.H., Ricard,J., Bethea,J.R., Liebl,D.J. EphB3 Limits the Expansion of Neural Progenitor Cells in the Subventricular Zone by Regulating p53 During Homeostasis and Following Traumatic Brain Injury. Stem Cells 2010; 28(-7-):1231-1242. >>> Ephrin B3-Fc; CSF/CNS; Mice; 1007D; 3 days; Controls received mp w/ Human Fc control; animal info (male, 2-4 months old, mutant CD1, ephrinB3 -/-, Eph3 -/-, CCI injured).

Q0060 Tschoep,J., Nogueiras,R., Haas-Lockie,S., Kasten,K.R., Castaneda,T.R., Huber,N., Guanciale,K., Perez-Tilve,D., Habegger,K., Ottaway,N., Woods,S.C., Oldfield,B., Clarke,I., Chua,S Jr, Farooqi,I.S., O'Rahilly,S., Caldwell,C.C., Tschoep,M.H. CNS Leptin Action Modulates Immune Response and Survival in Sepsis. Journal of Neuroscience 2010; 30(-17-):6036-6047. >>> Leptin; Saline, isotonic; SC; CSF/CNS; Mice; 1003D; 14 days; Controls received mp w/ vehicle; cyanoacrylate adhesive; ALZET brain infusion kit 3 used; animal info (male, ob/ob, wt, 8-10 wks old); post op. care (buprenorphine).

Q0059 Ubhi,K., Rockenstein,E., Mante,M., Inglis,C., Adame,A., Patrick,C., Whitney,K., Masliah,E. Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors. Journal of Neuroscience 2010; 30(-18-):6236-6246. >>> Glial-derived neurotrophic factor; CSF/CNS; Mice; 1002; 14 days; Animal info (MBP-h alpha syn Tg, 8 months old).

Q0089 Veeravalli,K.K., Chetty,C., Ponnala,S., Gondi,C.S., Lakka,S.S., Fassett,D., Klopfenstein,J.D., Dinh,D.H., Gujrati,M., Rao,J.S. MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice. PLoS One 2010; 5(-7-):U28-U42. >>> MMP-9; uPAR; cathepsin B; CSF/CNS; Mice; ; Pump infused at a rate of 0.2 u/hr.

Q0837 Warner-Schmidt,J.L., Chen,E.Y., Zhang,X.Q., Marshall,J.J., Morozov,A., Svenningsson,P., Greengard,P. A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor. Biological Psychiatry 2010; 68(-6-):528-535. >>> Brain-derived neurotrophic factor, recomb.; CSF/CNS; Mice (transgenic); 1003D; 3 days; Animal info (8-10 wks old, C57BL/6, BDNF Tg); behavioral testing (tail suspension test, forced swim test, open field locomotor activity); Plastics One cannula used.

Q0259 Yaguchi,T., Nagata,T., Yang,D.Q., Nishizaki,T. Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity. Behavioural Brain Research 2010; 206(-1-):47-51. >>> Interleukin-18; CSF/CNS; Mice; 1007D; 4 days; Controls received mp w/ serum; animal info (wt, IL-18 KO); behavioral testing (water maze test).

Q0412 Yamauchi,T., Tatsumi,K., Makinodan,M., Kimoto,S., Toritsuka,M., Okuda,H., Kishimoto,T., Wanaka,A. Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus. NEUROCHEMISTRY INTERNATIONAL 2010; 57(-5-):565-571. >>> Ara-C; CSF/CNS; Mice; 1002; 4 weeks; Controls received mp w/aCSF; animal info (Female C57BL/6J, 10 wks old); pumps replaced after 2 weeks; ALZET brain infusion kit 3 used; 2-day delayed infusion by filling vinyl tubing with artificial CSF.

Q0497 Yin,K.J., Deng,Z., Huang,H.R., Hamblin,M., Xie,C.Q., Zhang,J.F., Chen,Y.E. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. NEUROBIOLOGY OF DISEASE 2010; 38(-1-):17-26. >>> Oligonucleotide, antisense; CSF, artificial; CSF/CNS; Mice; 1003D; ; Negative controls received mp w/ miR-antagomir negative control or artificial CSF; antisense (miR-497); animal info (male, C57/Bl6); ischemia (focal cerebral).

Q0064 Yin,K.J., Deng,Z., Hamblin,M., Xiang,Y., Huang,H.R., Zhang,J.F., Jiang,X.D., Wang,Y.Z., Chen,Y.E. Peroxisome Proliferator-Activated Receptor-delta Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury. Journal of Neuroscience 2010; 30(-18-):6398-6408. >>> GW501516; CSF/CNS; Mice; 1003D; ; Controls received mp w/ vehicle; ischemia (cerebral).

P9528 Abdipranoto-Cowley,A., Park,J.S., Croucher,D., Daniel,J., Henshall,S., Galbraith,S., Mervin,K., Vissel,B. Activin A Is Essential for Neurogenesis Following Neurodegeneration. Stem Cells 2009; 27(-6-):1330-1346. >>> Activin A; follistatin-288; BSA; PBS; CSF/CNS; Mice; 7 days, 72 hours; Animal info (C57BL/6, 8-16 wks old); 0.1% BSA used; Plastics One cannula; IRA pellet with minocyline implanted SC concurrently; activin delivered for 7 days.

Q0165 Abdul,H.M, Furman,J.L., Sama,M.A., Mathis,D.M., Norris,C.M  Mol Cel Pharmacol 2009; 2(-1-):7-14. >>> VIVT peptide; scrambled control peptide; CSF/CNS; Mice; 14 days; Controls received mp w/ scrambeled control peptide; peptides; animal info (14 months old, APP, P51); VIVT is an immunosuppressive peptide.

P9635 Bartolomucci,A., Bresciani,E., Bulgarelli,I., Rigamonti,A.E., Pascucci,T., Levi,A., Possenti,R., Torsello,A., Locatelli,V., Muller,E.E., Moles,A. Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice. Genes and Nutrition 2009; 4(-1-):49-57. >>> TLQP-21, synthetic; CSF, artificial; CSF/CNS; Mice; 1002; 14 days; Controls received mp w/vehicle; ALZET brain infusion kit used; animal info (male, Swiss, CD-1, 30-35g); cannula placement confirmed by ICV injection of colorant; obesity.

Q0458 Belinson,H., Michaelson,D.M. ApoE4-dependent A-beta-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum. Journal of Neural Transmission 2009; 116(-11-):1427-1434. >>> Thiorphan; CSF, artificial; ascorbic acid; CSF/CNS; Mice; ; Animal info (ApoE, 3-4 months old, male); neurodegenerative (Alzheimer's disease).

Q0457 Blackmore,D.G., Golmohammadi,M.G., Large,B., Waters,M.J., Rietze,R.L. Exercise Increases Neural Stem Cell Number in a Growth Hormone-Dependent Manner, Augmenting the Regenerative Response in Aged Mice. Stem Cells 2009; 27(-8-):2044-2052. >>> Growth hormone, recomb. rat; Saline; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle; cyanoacrylate adhesive; animal info (C57BL/6J 6-8 wks old, female).

Q0465 Breton-Provencher,V., Lemasson,M., Peralta,MR III, Saghatelyan,A. Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors. Journal of Neuroscience 2009; 29(-48-):15245-15257. >>> Ara-C; Saline; CSF/CNS; Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (C57BL/6J, male); oxygenated artificial CSF formula, pg 15246; behavioral testing (object recognition, novelty suppressed feeding behavior, tail suspension, odor detection threshold, odor discrimination, long term odor-associative memory, olfactory short-term memory).

P9755 Cheng,L.C., Pastrana,E., Tavazoie,M., Doetsch,F. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nature Neuroscience 2009; 12(-4-):399-408. >>> Oligonucleotide, antisense; Ara-C; Saline; CSF/CNS; Mice; 1007D; 12, 14 days; Pumps replaced after 6 days; antisense (miR-124); animal info (2 months old, CD-1); brain tissue distribution.

Q0567 Clausen,F., Haanell,A., Bjoerk,M., Hillered,L., Mir,A.K., Gram,H., Marklund,N. Neutralization of interleukin-1-beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice. European Journal of Neuroscience 2009; 30(-3-):385-396. >>> Antibody, monoclonal IgG2a/k; CSF/CNS; Mice; 2004; 2 weeks; Controls received mp w/ control antibody anti-CsA-IgG); animal info (male C57BL/ 6, 25-27 g); ALZET brain infusion kit 2 used; IgG2a/k is a IL-1b neutralizing antibody.

P9881 Fernandez,A., Llacuna,L., Fernandez-Checa,J.C., Colell,A. Mitochondrial Cholesterol Loading Exacerbates Amyloid-beta Peptide-Induced Inflammation and Neurotoxicity. Journal of Neuroscience 2009; 29(-20-):6394-6405. >>> Amyloid protein, beta (1-42), human oligomeric; lipoprotein, high density; glutathione ethyl ester; HEPES; CSF/CNS; Mice; 1004; 28 days; Controls received mp w/ vehicle; animal info (Tg-SREBP-2, NPC1-/-, Tg-APP/PS1); neurodegenerative (Alzheimer's Disease).

P9791 Funato,H., Tsai,A.L., Willie,J.T., Kisanuki,Y., Williams,S.C., Sakurai,T., Yanagisawa,M. Enhanced orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity. Cell Metabolism 2009; 9(-1-):64-76. >>> Orexin-b; PBS; CSF/CNS; Mice; 2001; 10, 14 days; Controls received mp w/ vehicle; ALZET brain infusion kit 3 used; animal info (male, ob/ob, 12 wks old; 3-4 months old, C57BL/6J); brain tissue distribution.

P9702 Furne,C., Ricard,J., Cabrera,J.R., Pays,L., Bethea,J.R., Mehlen,P., Liebl,D.J. EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2009; 1793(-2-):231-238. >>> EphrinB3-Fc; Z-VAD-fmk; CSF/CNS; Mice; 7 days; Animal info (2 mo. old, male, EphrinB3-/-, wt).

Q0550 Ghia,J.E., Blennerhassett,P., Deng,Y.K., Verdu,E.F., Khan,W.I., Collins,S.M. Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression. Gastroenterology 2009; 136(-7-):2280-2288. >>> Reserpine; choline chloride; methyllycaconitine; Water; acetic acid; CSF/CNS; IP; Mice; 5, 10, 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6, 7-9 wks old, alpha 7nAchR -/-); post op. care (buprenorphine); Plastics One cannula used with PE60 tubing.

Q0432 Glick,M., Segal-Lieberman,G., Cohen,R., Kronfeld-Schor,N. Chronic MCH infusion causes a decrease in energy expenditure and body temperature, and an increase in serum IGF-1 levels in mice. Endocrine 2009; 36(-3-):479-485. >>> Melanin concentrating hormone; CSF, artificial; CSF/CNS; Mice; 2002; 14 days; Controls received mp w/ vehicle; peptides; cyanoacrylate adhesive; animal info (12 wks old, C57BL/6); cannula placement verified post morten with Evans Blue dye; endocrinology.

Q0681 Gobeske,K.T., Das,S., Bonaguidi,M.A., Weiss,C., Radulovic,J., Disterhoft,J.F., Kessler,J.A. BMP Signaling Mediates Effects of Exercise on Hippocampal Neurogenesis and Cognition in Mice. PLoS One 2009; 4(-10-):U104-U125. >>> Noggin; ara-C; CSF/CNS; Mice; 1002; 14 days; Controls received mp w/ vehicle; animal info (adult, male, NSE-noggin, NSE-BMP4); "Cannula placement and pump integrity were confirmed in all cases." pg e7507.

Q0793 Gonzalez-Perez,O., Romero-Rodriguez,R., Soriano-Navarro,M., Garcia-Verdugo,J.M., varez-Buylla,A. Epidermal Growth Factor Induces the Progeny of Subventricular Zone Type B Cells to Migrate and Differentiate into Oligodendrocytes. Stem Cells 2009; 27(-8-):2032-2043. >>> Epidermal growth factor; BSA; saline; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle; animal info (adult, CD-1); schematic of pump and cannula placement, figure 4.

P9809 Halassa,M.M., Florian,C., Fellin,T., Munoz,J.R., Lee,S.Y., Abel,T., Haydon,P.G., Frank,M.G. Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss. Neuron 2009; 61(-2-):213-219. >>> CPT; DMSO; saline; CSF/CNS; Mice; 1002; ; Controls received mp w/ vehicle; ALZET brain infusion kit 3 used; animal info (dnSNARE); CPT alos known as 8-cyclopentyl-1,3-dimethylxanthine.

P9550 Hoang,S., Liauw,J., Choi,M., Choi,M., Guzman,R.G., Steinberg,G.K. Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 2009; 29(-2-):385-397. >>> Netrin, recomb. mouse; CSF, artificial; CSF/CNS; Mice; 1003D; ; Controls received mp w/vehicle; ischemia (focal cerebral); animal info (adult, male, C57BL/6J, 30-35g); brain tissue distribution; aCSF recipe.

P9543 Hong,H.S., Rana,S., Barrigan,L., Shi,A.B., Zhang,Y., Zhou,F.M., Jin,L.W., Hua,D.H. Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. Journal of Neurochemistry 2009; 108(-4-):1097-1108. >>> CP2; DMSO; CSF, artificial; CSF/CNS; Mice; 1002; 2 weeks; Controls received mp w/vehicle; Alzet brain infusion kit 3 used; animal info (3 mo old, 5xFAP); neurodegenerative (Alzheimer's disease); CP2 is a tricyclic pyrone.

Q0922 Ito,K., Hirooka,Y., Sunagawa,K. Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload. Circulation Research 2009; 104(-8-):1004-U200. >>> Sodium; CSF, artificial; CSF/CNS; Mice; 1004; 1002; 4 weeks; 14 days; Controls received sham operation or low dose sodium; animal info (ICR, 10 wks old); ALZET brain infusion kit 3 used.

P9603 Kim,C., Jeon,D., Kim,Y.H., Lee,C.J., Kim,H., Shin,H.S. Deletion of N-type Ca2+ Channel Cav2.2 Results in Hyperaggressive Behaviors in Mice. Journal of Biological Chemistry 2009; 284(-5-):2738-2745. >>> Vasopressin, 1-desamino-8-D arginine; PBS; CSF/CNS; Mice; ; Controls received mp w/vehicle; animal info (Cav 2.2 -/-, male, 10-15 wks old); behavoral testing (resident intruder testing).

Q0150 Kim,G.W., Kim,H.J., Cho,K.J., Kim,H.W., Cho,Y.J., Lee,B.I. The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus. NEUROBIOLOGY OF DISEASE 2009; 36(-1-):169-180. >>> Antibody, anti-beta1-integrin, monoclonal; Saline; CSF/CNS; Mice; 1003D; 3 days; Animal info (adult, male, C57BL/6, 20-25 g).

P9865 Kocerha,J., Faghihi,M.A., Lopez-Toledano,M.A., Huang,J., Ramsey,A.J., Caron,M.G., Sales,N., Willoughby,D., Elmen,J., Hansen,H.F., Orum,H., Kauppinen,S., Kenny,P.J., Wahlestedt,C. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-9-):3507-3512. >>> MK-801; oligonucleotide, antisense; SC; CSF/CNS; Mice; 1002; 2002; 5, 7 days; Controls received mp w/ saline; antisense (LNA-antimiR-219); animal info (12 wks old, 25 g.); tygon tubing used; MK-801 also known as dizocilpine.

Q0275 Li,J.H., Chian,R.J., Ay,I., Kashi,B.B., Celia,S.A., Tamrazian,E., Pepinsky,R.B., Fishman,P.S., Brown,RH Jr, Francis,J.W. Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS. Biochemical and Biophysical Research Communications 2009; 390(-3-):947-951. >>> Glial-derived neurotrophic factor, recombinant, rat; glial-derived neurotrophic factor, TTC; HEPES; NaCl; BSA; CSF/CNS; Mice; 1 week; Controls received mp w/ vehicle; animal info (normal, male, C57BL6, 8-10-wks-old, 25-30 g); GDNF:TTC also known as glial-derivied neurotrophic factor: tetanus toxin C-fragment fusion protein.

P9547 Li,Y.Z., Perry,T., Kindy,M.S., Harvey,B.K., Tweedie,D., Holloway,H.W., Powers,K., Shen,H., Egan,J.M., Sambamurti,K., Brossi,A., Lahiri,D.K., Mattson,M.P., Hoffer,B.J., Wang,Y., Greig,N.H. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-4-):1285-1290. >>> Exendin-4; CSF/CNS; Mice; 2004; 7 days; Controls received mp w/PBS; animal info (C57BL/6, adult, male, 22-24g).

P9552 Lourenco,F.C., Galvan,V., Fombonne,J., Corset,V., Llambi,F., Mueller,U., Bredesen,D.E., Mehlen,P. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. CELL DEATH AND DIFFERENTIATION 2009; 16(-5-):655-663. >>> Netrin-1, recomb. mouse; CSF/CNS; Mice (transgenic); 1002; 12-13 days; Animal info (PDAPP); neurodegenerative (Alzheimer's disease).

P9353 Matsushita,H., Ishihara,A., Mashiko,S., Tanaka,T., Kanno,T., Iwaasa,H., Ohta,H., Kanatani,A. Chronic Intracerebroventricular Infusion of Nociceptin/Orphanin FQ Produces Body Weight Gain by Affecting Both Feeding and Energy Metabolism in Mice. Endocrinology 2009; 150(-6-):2668-2673. >>> Nociceptin/OrphaninFQ; Saline; BSA; CSF/CNS; Mice; 2002; 2004; 12 days; Controls received mp w/ vehicle; saline pumps replaced after 2 week recovery period with N/OFQ filled pumps; ALZET brain infusion kit used; post op. care (Cefamezin alpha); animal info (male, C57BL/6, 17 or 28 wks old); N/OFQ is an endogenous ligand for opioid receptor-like 1 (ORL1).

R0263 Merrill,J.E. In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination. Neuropsychopharmacology 2009; 34(-1-):55-73. >>> Antibody, anti-LINGO-1; Prolactin; CSF/CNS; intrathecal; SC; IP; Mice; rat; 2-3 weeks; Animal info (MOG-induced Experimental Autoimmune Encephalomyelitis).

Q0627 Miyamoto,N., Tanaka,R., Shimosawa,T., Yatomi,Y., Fujita,T., Hattori,N., Urabe,T. Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice. Journal of Cerebral Blood Flow and Metabolism 2009; 29(-11-):1769-1779. >>> H89; CSF/CNS; Mice; 1002; 8 days; Controls received mp w/ saline; animal info (8 wks old, male, AM+/-, C57BL/6 Wt); enzyme inhibitor (PKA, protein kinase A); middle cerebral artery occlusion (MCAO).

Q0713 Moreno,M.M., Linster,C., Escanilla,O., Sacquet,J., Didier,A., Mandairon,N. Olfactory perceptual learning requires adult neurogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-42-):17980-17985. >>> Ara-C; Saline; CSF/CNS; Mice; 21 days; Controls received mp w/ vehicle; animal info (adult, male, C57BL/6J, 8 weeks old).

P9847 Moriya,R., Mashiko,S., Ishihara,A., Takahashi,T., Murai,T., Ito,J., Mitobe,Y., Oda,Z., Iwaasa,H., Takehiro,F., Kanatani,A. Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice. Peptides 2009; 30(-7-):1318-1322. >>> Neuropeptide Y, D-Trp34; peptide YY (3-36); Saline; BSA; CSF/CNS; Mice; 2001; 2002; 7, 14 days; Controls received mp w/ vehicle; pumps replaced after 2 weeks; peptides; animal info (C57BL/6, 12-18 wks old); PBS/BSA in 2002 pump was replaced with NPP in 2001 after 2 week recovery period; obesity.

Q0391 Nam,H.S., Benezra,R. High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells. Cell Stem Cell 2009; 5(-5-):515-526. >>> Ara-C; CSF, artificial; CSF/CNS; Mice; 6 days; Animal info (GFAP:LSL-GFP, 6 wks old); 6 days; ALZET brain infusion kit used.

Q0696 Neigh,G.N., Karelina,K., Glasper,E.R., Bowers,S.L.K., Zhang,N., Popovich,P.G., DeVries,A.C. Anxiety After Cardiac Arrest/Cardiopulmonary Resuscitation Exacerbated by Stress and Prevented by Minocycline. Stroke 2009; 40(-11-):3601-3607. >>> Minocycline; CSF, artificial; CSF/CNS; Mice; 1002; ; Controls received mp w/ vehicle; animal info (adult, male, C57BL/6); behavioral testing (locomotor activity, rearing, central tendency); 2.5-day delayed infusion accomplished by filling catheter and cannula with vehicle; cannula placement verified with cresyl violet staining after tissue collection.

P9652 Nogueiras,R., Perez-Tilve,D., Veyrat-Durebex,C., Morgan,D.A., Varela,L., Haynes,W.G., Patterson,J.T., Disse,E., Pfluger,P.T., Lopez,M., Woods,S.C., DiMarchi,R., Dieguez,C., Rahmouni,K., Rohner-Jeanrenaud,F., Tschoep,M.H. Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity. Journal of Neuroscience 2009; 29(-18-):5916-5925. >>> Glucagon-like peptide-1 (7-36); exendin (9-39); CSF/CNS; Mice; 1003D; 1007D; 7 days; 48 hours; Controls received mp w/Saline; ALZET brain infusion kit 3 used; post op. care (buprenorphine); animal info (8 wks old, wt, eTKO).

Q0203 Park,J.H., Bonthuis,P., Ding,A., Rais,S., Rissman,E.F. Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice. Hormones and Behavior 2009; 56(-2-):254-263. >>> ICI 182,780; DMSO; CSF, artificial; CSF/CNS; Mice; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (50-80 days old, male, B6D2F1); 0.6% DMSO used.

P9624 Peier,A., Kosinski,J., Cox-York,K., Qian,Y., Desai,K., Feng,Y., Trivedi,P., Hastings,N., Marsh,D.J. The Antiobesity Effects of Centrally Administered Neuromedin U and Neuromedin S Are Mediated Predominantly by the Neuromedin U Receptor 2 (NMUR2). Endocrinology 2009; 150(-7-):3101-3109. >>> Neuromedin U, human; CSF, artificial; CSF/CNS; Mice; 14 days; Controls received mp w/vehicle; peptides; animal info (8 wks old, Nmur2 -/-).

P9691 Popiel,H.A., Nagai,Y., Fujikake,N., Toda,T. Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice. Neuroscience Letters 2009; 449(-2-):87-92. >>> PolyQ-binding peptide 1, Antp-; CSF/CNS; Mice (transgenic); ; Peptides; animal info (4 wks old, R6/2); neurodegenerative (Polyglutamine Disease); brain tissue distribution.

P9891 Ramadori,G., Gautron,L., Fujikawa,T., Vianna,C.R., Elmquist,J.K., Coppari,R. Central Administration of Resveratrol Improves Diet-Induced Diabetes. Endocrinology 2009; 150(-12-):5326-5333. >>> Resveratrol; Saline, sterile; CSF/CNS; Mice; 1004; 5 weeks; Controls received mp w/vehicle; animal info (C57BL/6, male); "This daily dose of resveratrol (0.03mg/ul) is approximately 8.5 million or approximately 152 million times lower, respectively, compared with the dose orally delivered in two previous studies" pg 5327; diabetes; endocrinology.

P9660 Rose,J.B., Crews,L., Rockenstein,E., Adame,A., Mante,M., Hersh,L.B., Gage,F.H., Spencer,B., Potkar,R., Marr,R.A., Masliah,E. Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease. Journal of Neuroscience 2009; 29(-4-):1115-1125. >>> Neuropeptide Y, c-terminal fragments amidated; Neuropeptide Y, c-terminal fragments non-amidated; DSMO; NaCl; CSF/CNS; Mice; 2004; 28 days; Controls received mp w/vehicle; animal info (NEP, APP, doubt tg. 6mo); 10% DMSO used.

Q0368 Sims,J.R., Lee,S.W., Topalkara,K., Qiu,J.H., Xu,J., Zhou,Z.P., Moskowitz,M.A. Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation. Stroke 2009; 40(-11-):3618-3626. >>> Cyclopamine; PBS; DMSO; CSF/CNS; Mice; 1007D; ; Controls received mp w/ vehicle; animal info (SV129 male, 10-12 wks old); MCAO; 0.1% DMSO used.

P9804 Singer,B.H., Jutkiewicz,E.M., Fuller,C.L., Lichtenwalner,R.J., Zhang,H., Velander,A.J., Li,X.Q., Gnegy,M.E., Burant,C.F., Parent,J.M. Conditional Ablation and Recovery of Forebrain Neurogenesis in the Mouse. Journal of Comparative Neurology 2009; 514(-6-):567-582. >>> Ganciclovir; Saline; CSF/CNS; Mice; 2004; 28 days; Controls received mp w/ vehicle; no stress (572); ALZET brain infusion kit 3 used; animal info (8-12 wks old, Nestin tk+. wt); "we did not observe any differences in the overt behavior of wild-type or nestin-tk+ mice, and there was no mortality following GCV administration." pg 572.

P9648 Tamma,R., Colaianni,G., Zhu,L.L., DiBenedetto,A., Greco,G., Montemurro,G., Patano,N., Strippoli,M., Vergari,R., Mancini,L., Colucci,S., Grano,M., Faccio,R., Liu,X., Li,J.H., Usmani,S., Bachar,M., Bab,I., Nishimori,K., Younge,L.J., Buettner,C., Iqbal,J., Sun,L., Zaidi,M., Zallone,A. Oxytocin is an anabolic bone hormone. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-17-):7149-7154. >>> Oxytocin; CSF/CNS; Mice; 5 days; Animal info (male female, OT-/-, Otr-/-).

Q0376 Tauber,S.C., Ebert,S., Weishaupt,J.H., Reich,A., Nau,R., Gerber,J. Stimulation of Toll-Like Receptor 9 by Chronic Intraventricular Unmethylated Cytosine-Guanine DNA Infusion Causes Neuroinflammation and Impaired Spatial Memory. Journal of Neuropathology and Experimental Neurology 2009; 68(-10-):1116-1124. >>> DNA, cytosine-guanine; CSF/CNS; Mice; 2004; 4 weeks; Controls received mp w/saline; animal info (male, C57BL/6, TLR9-deficient); ALZET brain infusion kit 2 used; stress/adverse reaction: (see pg. 1117) "One C57BL/6 mouse died because of complications during the operation, and 1 TLR9-deficient mouse died for unknown reasons 2 weeks after implantation of the pump"..

P9867 Thakker,D.R., Weatherspoon,M.R., Harrison,J., Keene,T.E., Lane,D.S., Kaemmerer,W.F., Stewart,G.R., Shafer,L.L. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009; 106(-11-):4501-4506. >>> Immunogloculin G1; 6E10; CSF/CNS; Mice; 2004; ; Functionality of mp verified in vitro for 5 weeks; stability verified in vitro for 5 weeks; animal info (male, 16-18 months old, Tg2576); neurodegenerative (Alzheimer's Disease); 6E10 is a mouse monoclonal IgG1; brain tissue distribution.

P9462 White,C.L., Whittington,A., Barnes,M.J., Wang,Z., Bray,G.A., Morrison,C.D. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2009; 296(-2-):E291-E299. >>> Leptin; Saline; SC; CSF/CNS; Rat; mice; 10, 14 days; Controls received mp w/ vehicle; comparison of IP, ICV injections vs. mp; peptides; post op. care (analgesics); animal info (male, Long Evans, 10 wks old; C57BL/6 wt, ob/ob, 8 wks old).

P9971 Xue,B.J., Singh,M., Guo,F., Hay,M., Johnson,A.K. Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-5-):H1638-H1646. >>> L-NAME; L-VNIO; Angiotensin II; SC; CSF/CNS; Mice; 1002; 7, 14 days; Controls received mp w/ vehicle; peptides; cardiovascular; enzyme ihibitor (NO synthase); animal info (male, female, C57BL/6, 12-16 weeks old); replacement therapy (ovariectomy, gonadectomy); cannula placement confirmed post mortem histologically; N5-(1-imino-3-butenyl)-L-ornithine (L-VNIO).

Q0381 Zhao,M., Lang,A.M.J. Bromodeoxyuridine infused into the cerebral ventricle of adult mice labels nigral neurons under physiological conditions-A method to detect newborn nerve cells in regions with a low rate of neurogenesis. Journal of Neuroscience Methods 2009; 184(-2-):327-331. >>> Uridine, bromodeoxy; thymidine, 3H; PBS; NaOH; CSF/CNS; IP; Mice; 2004; 1003D; ; Animal info (adult, male, C57BL/6, 10 wks old); labeling of neurons; ALZET brain infusion kit used.