References on the Intracerebroventricular Administration of Agents to Rats Using ALZET^® Osmotic Pumps

Q0870 Bai,Y.Y., Chang,F., Zhou,R., Jin,P.P., Matsumoto,H., Sokabe,M., Chen,L. Increase of Anteroventral Periventricular Kisspeptin Neurons and Generation of E2-Induced LH-Surge System in Male Rats Exposed Perinatally to Environmental Dose of Bisphenol-A. Endocrinology 2011; 152(-4-):1562-1571. >>> P234; NaCl; CSF/CNS; Rat; 2001; 15 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, male, adult, 200-250 g, PND35); P234 is a GPR54 antagonist.

Q0887 Barrera,J.G., Jones,K.R., Herman,J.P., D'Alessio,D.A., Woods,S.C., Seeley,R.J. Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function. Journal of Neuroscience 2011; 31(-10-):3904-3913. >>> Exendin (9-39); Saline; CSF/CNS; Rat; 2006; 2004; 4, 6 weeks; Controls received mp w/ vehicle; animal info (adult, male, Long-Evans); long-term study; Research Diets; obesity.

Q0862 Bonzon-Kulichenko,E., Fernandez-Agullo,T., Molto,E., Serrano,R., Fernandez,A., Ros,M., Carrascosa,J.M., Arribas,C., Martinez,C., Andres,A., Gallardo,N. Regulation of Insulin-Stimulated Glucose Uptake in Rat White Adipose Tissue upon Chronic Central Leptin Infusion: Effects on Adiposity. Endocrinology 2011; 152(-4-):1366-1377. >>> Leptin, rat; PBS; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 3-mo old); peptides.

Q0662 German,J.P., Thaler,J.P., Wisse,B.E., Oh,I., Sarruf,D.A., Matsen,M.E., Fischer,J.D., Taborsky,GJ Jr, Schwartz,M.W., Morton,G.J. Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia. Endocrinology 2011; 152(-2-):394-404. >>> Leptin; PBS; CSF/CNS; Rat; 11 days; Controls received mp w/ vehicle; animal info (adult, male, Wistar); peptides; pump implanted following 7-day recovery period after cannula insertion.

Q0905 Hansson,C., Haage,D., Taube,M., Egecioglu,E., Salome,N., Dickson,S.L. CENTRAL ADMINISTRATION OF GHRELIN ALTERS EMOTIONAL RESPONSES IN RATS: BEHAVIOURAL, ELECTROPHYSIOLOGICAL AND MOLECULAR EVIDENCE. Neuroscience 2011; 180(-;-):201-211. >>> Ghrelin; Saline; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 270-300 g); peptides; ALZET brain infusion kit 2 used.

Q0900 Jang,S., Kim,D., Lee,Y., Moon,S., Oh,S. Modulation of Sphingosine 1-Phosphate and Tyrosine Hydroxylase in the Stress-Induced Anxiety. Neurochemical Research 2011; 36(-2-):258-267. >>> Sphingosine 1-phosphate; CSF/CNS; Rat; 2ML1; 7 days; Controls received mp w/ saline; animal info (Sprague-Dawley, male, 260-280 g); pump implanted following 1 week recovery period after cannulation; PE-60 tubing used.

Q0733 Murphy,K.J., Miller,A.M., Thelma,R., Cowley,F., Cox,F.F., Lynch,M.A. The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation. NEUROCHEMISTRY INTERNATIONAL 2011; 58(-2-):161-168. >>> Amyloid protein, beta (1-40); amyloid protein, beta (1-42); CSF/CNS; Rat; 2004; 8 days; Controls received mp w/ reverse peptide 40-1; animal info (Wistar, male, 3 mo old, 250-350 g, 22 mo old, 550-650 g); peptides; ALZET brain infusion kit II used.

Q0718 Petervari,E., Szabad,A.O., Soos,S., Garami,A., Szekely,M., Balasko,M. Central alpha-MSH infusion in rats: Disparate anorexic vs. metabolic changes with aging. REGULATORY PEPTIDES 2011; 166(-1-3-):105-111. >>> Melanocyte stimulating hormone, alpha; Saline, pyrogen free; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Wistar, 2 mo, 3-4 mo, 12 mo, 24 mo old, ); ALZET brain infusion kit used; cannula placement verified macroscopically; 12 hour delayed delivery due to "dead-space of the connecting tube".

Q0636 Tsai,S.Y., Papadopoulos,C.M., Schwab,M.E., Kartje,G.L. Delayed Anti-Nogo-A Therapy Improves Function After Chronic Stroke in Adult Rats. Stroke 2011; 42(-1-):186-190. >>> Antibody, anti-Nogo-A; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/ inactive control antibody or no treatment; animal info (adult, male, Long Evans, black-hooded, 300 g); ischemia (stroke).

Q0679 Zhu,D.L., Shi,J.P., Zhang,Y.D., Wang,B.R., Liu,W., Chen,Z.C., Tong,Q.A. Central Angiotensin II Stimulation Promotes beta Amyloid Production in Sprague Dawley Rats. PLoS One 2011; 6(-1-):U121-U129. >>> Angiotensin II; Saline, sterile; CSF/CNS; Rat; 2004; 1 week; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 280-310 g); peptides; ALZET brain infusion kit used.

Q0318 Abrams,J.M., Engeland,W.C., Osborn,J.W. Effect of intracerebroventricular benzamil on cardiovascular and central autonomic responses to DOCA-salt treatment. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 299(-6-):R1500-R1510. >>> Benzamil; CSF/CNS; Rat; 2004; 47 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 200-225 g); long-term study; ALZET brain infusion kit 2 used; pumps replaced on day 21; rate of rat cerebrospinal fluid production (3.7 +/- 0.1 ul/min) R1501..

Q0396 Agudo,M., Yip,P., Davies,M., Bradbury,E., Doherty,P., McMahon,S., Maden,M., Corcoran,J.P.T. A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. NEUROBIOLOGY OF DISEASE 2010; 37(-1-):147-155. >>> CD2019; CSF/CNS; Rat; ; Animal info (adult, dorsal column lesions, male); ALZET brain infusion kit used; CD2019 is a retinoic acid receptor beta agonist; 0.5 ul/hr, 14 day pump used.

Q0398 Alkadhi,K.A., Srivareerat,M., Tran,T.T. Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease. MOLECULAR AND CELLULAR NEUROSCIENCE 2010; 45(-3-):289-296. >>> Amyloid protein, beta (1-40); amyloid protein, beta 1-42; Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ amyloid protein beta non-pathogenic reverse peptide; animal info (adult, male, Wistar, 200-225 g); neurodegenerative (Alzheimer's disease).

Q0883 Benoit,C.E., Bastianetto,S., Brouillette,J., Tse,Y., Boutin,J.A., Delagrange,P., Wong,T., Sarret,P., Quirion,R. Loss of Quinone Reductase 2 Function Selectively Facilitates Learning Behaviors. Journal of Neuroscience 2010; 30(-38-):12690-12700. >>> S26695; DMSO; saline; CSF/CNS; Rat; 2001; 1 week; Animal info (3-4 mo old); enzyme inhibitor (quinone reductase 2); behavioral testing (Morris maze test); 10% DMSO used.

Q0400 Bogaert,E., Van Damme,P., Poesen,K., Dhondt,J., Hersmus,N., Kiraly,D., Scheveneels,W., Robberecht,W., Van den Bosch,L. VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. NEUROBIOLOGY OF AGING 2010; 31(-12-):2185-2191. >>> Vascular endothelial growth factor; CSF/CNS; Rat; 2004; 1 week; Controls received mp w/ vehicle; animal info (80 days old).

P9966 Fang,P.C., Barbay,S., Plautz,E.J., Hoover,E., Strittmatter,S.M., Nudo,R.J. Combination of NEP 1-40 Treatment and Motor Training Enhances Behavioral Recovery After a Focal Cortical Infarct in Rats. Stroke 2010; 41(-3-):544-549. >>> NEP (1-40); PBS; DMSO; CSF/CNS; Rat; 2ML4; 28 days; ALZET brain infusion kit 2 used; animal info (Long Evans, adult, male); 2.5% DMSO used; cannula implanted first, pump implanted following recovery period of 7 days; behavioral testing (skilled reach test, motor trainning, foot faul test, cylinder test); NEP (1-40) also known as NOGO extracellular peptide.

Q0115 Garcia-Galiano,D., Navarro,V.M., Roa,J., Ruiz-Pino,F., Sanchez-Garrido,M.A., Pineda,R., Castellano,J.M., Romero,M., Aguilar,E., Gaytan,F., Dieguez,C., Pinilla,L., Tena-Sempere,M. The Anorexigenic Neuropeptide, Nesfatin-1, Is Indispensable for Normal Puberty Onset in the Female Rat. Journal of Neuroscience 2010; 30(-23-):7783-7792. >>> Oligonucleotide, antisense, morpholino; oligonucleotide, missense, morpholino; Saline; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ missense oligo; antisense (Nucleobindin 2); animal info (female, Wistar, 28 days old, adult); endocrinology.

P9896 Gillani,R.L., Tsai,S.Y., Wallace,D.G., O'Brien,T.E., Arhebamen,E., Tole,M., Schwab,M.E., Kartje,G.L. Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy. Behavioural Brain Research 2010; 208(-2-):415-424. >>> Antibody, anti-nogo-A; antibody, anti-wheat auxin; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/control antibody; animal info (male, Long Evans, black-headed, 18 mo old, MCAO).

Q0233 Gomez-Sanchez,E.P., Gomez-Sanchez,C.M., Plonczynski,M., Gomez-Sanchez,C.E. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Experimental Physiology 2010; 95(-1-):120-130. >>> FAD286; Propylene glycol; saline; CSF/CNS; Rat; 2004; ; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (Sprague Dawley, Dahl, salt sensitive); cannula placement verified post mortem with a dye.

Q0320 Huang,B.S., Ahmadi,S., Ahmad,M., White,R.A., Leenen,F.H.H. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway. American Journal of Physiology-Heart and Circulatory Physiology 2010; 299(-2-):U207-U215. >>> Angiotensin II; FAD-286; aldosterone, d-; Saline; CSF, artificial; ethanol; SC; CSF/CNS; Rat; 2001D; 2001; 2002; 2004; 2 weeks; 1, 4 days; Controls received mp w/ vehicle; animal info (male, Wistar, 200-250 g); peptides; dose-response; enzyme inhibitor (aldosterone synthase); multiple pumps per animal (2); telemetry probe (model TA11PA-C40, DSI) used to measure BP and HR; 1% ethanol used with aldosterone.

Q0130 Iwasa,T., Matsuzaki,T., Murakami,M., Fujisawa,S., Kinouchi,R., Gereltsetseg,G., Kuwahara,A., Yasui,T., Irahara,M. Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats. JOURNAL OF PHYSIOLOGY-LONDON 2010; 588(-5-):821-829. >>> Kisspeptin-10; SC; CSF/CNS; Rat; 2002; 14 days; Animal info (prepubertal, P27, Sprague Dawley).

Q0128 Kinsey-Jones,J.S., Li,X.F., Knox,A.M.I., Lin,Y.S., Milligan,S.R., Lightman,S.L., O'Byrne,K.T. Corticotrophin-Releasing Factor Alters the Timing of Puberty in the Female Rat. Journal of Neuroendocrinology 2010; 22(-2-):102-109. >>> Corticotrophin-releasing factor; astressin-B; CSF, artificial; CSF/CNS; Rat; 2002; 14, 14 days; Controls received no treatment/surgery; peptides; no stress (see pg. 105); animal info (female, Sprague-Dawley, 28 days old); dose-response (fig. 1); neuroendocrinology.

P9991 Kishi,T., Hirooka,Y., Konno,S., Ogawa,K., Sunagawa,K. Angiotensin II Type 1 Receptor-Activated Caspase-3 Through Ras/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in the Rostral Ventrolateral Medulla Is Involved in Sympathoexcitation in Stroke-Prone Spontaneously Hypertensive Rats. Hypertension 2010; 55(-2-):291-297. >>> S-Farnesylthiosalicylic acid; Z-DEVD-FMK; candesartan; DMSO; CSF, artificial; CSF/CNS; Rat; 1003D; 14 days; Controls received mp w/ vehicle; animal info (WYKO, 14-16 wks old).

P9952 Koo,J.W., Russo,S.J., Ferguson,D., Nestler,E.J., Duman,R.S. Nuclear factor-kappa-B is a critical mediator of stress-impaired neurogenesis and depressive behavior. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-6-):2669-2674. >>> JSH-23; SC-514; DMSO; PBS; CSF/CNS; Rat; mice (transgenic); 1004; 2004; ; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (adult, male, Sprague Dawley, 230-250 g., NF-Kb/LacZ transgenic, wt, 20-30 g.); 50% DMSO used; 4-5 day delayed vehicle infusion to allow a recovery period; JSH-23 is a nuclear factor.

Q0138 Koyama,Y., Tanaka,K. Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroscience Letters 2010; 469(-3-):343-347. >>> Endothelin-1, ala-1, 3, 11, 15-; CSF, artificial; CSF/CNS; Rat; 2002; 3, 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, Wistar, 250-300 g.).

Q0157 Lazo,O.M., Mauna,J.C., Pissani,C.A., Inestrosa,N.C., Bronfman,F.C. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Molecular Neurodegeneration 2010; 5(-;-):U1-U12. >>> Nerve growth factor; CSF, artificial; CSF/CNS; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (Sprague Dawley, 280-300 g.); aCSF recipe; incorrectly stated 2002 pump.

Q0135 Lecanu,L., Rammouz,G., McCourty,A., Sidahmed,E.K., Greeson,J., Papadopoulos,V. CAPROSPINOL REDUCES AMYLOID DEPOSITS AND IMPROVES COGNITIVE FUNCTION IN A RAT MODEL OF ALZHEIMER'S DISEASE. Neuroscience 2010; 165(-2-):427-435. >>> Amyloid protein, beta (1-42); buthionine suloximine; iron (II) sulfate; CSF/CNS; Rat; 2ML4; 8 weeks; Long-term study; pumps replaced after 4 weeks; animal info (Long Evans, 550 g); neurodegenerative (Alzheimer's Disease).

Q0021 Li,B., Piao,C.S., Liu,X.Y., Guo,W.P., Xue,Y.Q., Duan,W.M., Gonzalez-Toledo,M.E., Zhao,L.R. Brain self-protection: The role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Research 2010; 1327(-;-):91-102. >>> Ara-C; Saline; CSF/CNS; Mice; rat; 1007D; 7 days; Controls received mp w/vehicle; animal info (male, C57BL, 3 months old; male, SHR, 3-5 months old; CCAO, MCAO); ischemia (cerebral).

Q0356 Menn,B., Bach,S., Blevins,T.L., Campbell,M., Meijer,L., Timsit,S. Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models. PLoS One 2010; 5(-8-):U113-U123. >>> Roscovitine, S-; DMSO; Krebs-Ringer's solution; CSF/CNS; SC; Rat; mice; 1003D; 48, 72 hours; Controls received mp w/ vehicle; animal info (P60, male, C57B/6, 20-25 g; P60, male, Sprague Dawley, 280-320 g); ischemia (cerebral).

Q0890 Mizuno,M., Iwakura,Y., Shibuya,M., Zheng,Y.J., Eda,T., Kato,T., Takasu,Y., Nawa,H. Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning. JOURNAL OF PHARMACOLOGICAL SCIENCES 2010; 114(-3-):320-331. >>> PD153035; ZD1839; OSI-774; DMSO; saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley); behavioral testing (locomotor activity test, acoustic startle test, contextual conditioning); 10% DMSO used; PD153035, OSI-774, and ZD1839 is an epidermal growth factor receptor family (ErbB1) inhibitor.

Q0163 Park,S., Ahn,I.S., Kim,D.S. Central infusion of leptin improves insulin resistance and suppresses beta-cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model. LIFE SCIENCES 2010; 86(-23-24-):854-862. >>> Leptin; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 223 g.); aCSF recipe; diabetes.

Q0246 Petervari,E., Garami,A., Soos,S., Szekely,M., Balasko,M. Age-dependence of alpha-MSH-induced anorexia. Neuropeptides 2010; 44(-4-):315-322. >>> Melanocyte stimulating hormone, alpha; Saline, pyrogen free; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; ALZET brain infusion kit used; animal info (male, Wistar, 6-9 wks old, 3-4, 6, 12, 18, 24 mo old).

Q0080 Pineda,R., Garcia-Galiano,D., Roseweir,A., Romero,M., Sanchez-Garrido,M.A., Ruiz-Pino,F., Morgan,K., Pinilla,L., Millar,R.P., Tena-Sempere,M. Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist. Endocrinology 2010; 151(-2-):722-730. >>> P234; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (prepubertal, female, adult, cyclic); P234 is a kisspeptin antagonist.

Q0355 Pinnock,S.B., Blake,A.M., Platt,N.J., Herbert,J. The Roles of BDNF, pCREB and Wnt3a in the Latent Period Preceding Activation of Progenitor Cell Mitosis in The Adult Dentate Gyrus by Fluoxetine. PLoS One 2010; 5(-10-):U236-U243. >>> K252a; fluoxetine; Saline; CSF/CNS; SC; Rat; 1002; 2ML2; 7, 14 days; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 8 wks old, 200-250 g); multiple pumps per animal (2); cannula placement verified by examining its track on sections stained with cresyl violet.

Q0408 Ryu,H.J., Kim,J.E., Kim,M.J., Kwon,H.J., Suh,S.W., Song,H.K., Kang,T.C. THE PROTECTIVE EFFECTS OF INTERLEUKIN-18 AND INTERFERON-gamma ON NEURONAL DAMAGES IN THE RAT HIPPOCAMPUS FOLLOWING STATUS EPILEPTICUS. Neuroscience 2010; 170(-3-):711-721. >>> Antibody, anti IL-18; IL-18, recomb. rat; interferon, gamma, recomb. rat; antibody, anti interferon, gamma; IL-18 receptor antagonist; interferon, gamma, receptor antagonist; Saline; CSF/CNS; Rat; 1007D; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 7 wks old); ALZET brain infusion kit 1 used.

Q0185 Sangiao-Alvarellos,S., Varela,L., Vazquez,M.J., Da Boit,K., Saha,A.K., Cordido,F., Dieguez,C., Lopez,M. Influence of Ghrelin and Growth Hormone Deficiency on AMP-Activated Protein Kinase and Hypothalamic Lipid Metabolism. Journal of Neuroendocrinology 2010; 22(-6-):543-556. >>> Ghrelin, acyl; Saline; CSF/CNS; Rat; 2001; 2ML2; 8 days; Controls received mp w/ vehicle; peptides; animal info (male, Lewis, wt, GH deficient (dwarf), 2-3 months old, 365 g, 222 g); cannula placement confirmed by methylene blue staining; endocrinology.

Q0106 Sarruf,D.A., Thaler,J.P., Morton,G.J., German,J., Fischer,J.D., Ogimoto,K., Schwartz,M.W. Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats. Diabetes 2010; 59(-7-):1817-1824. >>> Fibroblast growth factor-21, recomb. human; BSA; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (male, Wistar, 250-275 g); Research diets D12492; diabetes.

Q0057 Selvamani,A., Sohrabji,F. The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1. Journal of Neuroscience 2010; 30(-20-):6852-6861. >>> Insulin-like growth factor-1; JB-1; CSF, artificial; CSF/CNS; Rat (pregnant); 1007D; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; cyanoacrylate adhesive; animal info (virgin, 3-4 months old, pregnant, 5-6 months old, retired, 9-11 months old); MCAO.

Q0066 Shi,P., ez-Freire,C., Jun,J.Y., Qi,Y.F., Katovich,M.J., Li,Q.H., Sriramula,S., Francis,J., Sumners,C., Raizada,M.K. Brain Microglial Cytokines in Neurogenic Hypertension. Hypertension 2010; 56(-2-):297-303. >>> Minocycline; angiotensin II; SC; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ saline; ALZET brain infusion kit used; multiple pumps per animal (2); post op. care (buprenorphine); animal info (male, Sprague Dawley, 6 wks old).

Q0244 Slattery,D.A., Neumann,I.D. Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats. Neuropharmacology 2010; 58(-1-):56-61. >>> Oxytocin; oxytocin receptor antagonist; Ringer's solution; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, female, HAB, LAB, Wistar, 250-350 g.); behavioral testing (light-dark box, elevated plus-maze, forced swim test); cannula placement verified post mortem by injecting blue dye into the cannula.

Q0813 Sugaya,Y., Maru,E., Kudo,K., Shibasaki,T., Kato,N. Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus. Brain Research 2010; 1352(-;-):187-199. >>> Levetiracetam; Saline; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 8 wks old); 15 ul saline allowed for 3-day delayed delivery followed by 25-day levetiracetam delivery; "A preliminary study in which a mini-pump was filled with bromophenol blue instead of levetiracetam, confirmed that the pumped drug solution was constantly separated from the predrug saline for 3 days at 37°C." pg 196.

Q0500 Tran,T.T., Srivareerat,M., Alkadhi,K.A. Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease. NEUROBIOLOGY OF DISEASE 2010; 37(-3-):756-763. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2 weeks; Controls received mp w/ amyloid protein beta (42-1); peptides; animal info (Wistar, 200-225 g); 14-day pump used; neurodegenerative (Alzheimer's Disease).

Q0242 Van Kampen,J.M., Eckman,C.B. Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation. Neuropharmacology 2010; 58(-6-):921-929. >>> Physostigmine; carbachol; nicotine; pirenzepine; oxotremorine; mecamylamine; Saline; CSF/CNS; Rat; 2002; 2004; ; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 250 g.); neurodegenerative (Alzheimer's Disease).

Q0471 Verty,A.N.A., Allen,A.M., Oldfield,B.J. The Endogenous Actions of Hypothalamic Peptides on Brown Adipose Tissue Thermogenesis in the Rat. Endocrinology 2010; 151(-9-):4236-4246. >>> SB-334867-A; SNAP-7941; SHU9119; Cyclodextrin, beta hydroxypropyl; DMSO; water, sterile; saline, physiological; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle; animal info (naïve, male, Sprague Dawley, 8 wks old, 200-300 g); 3-day delayed CNS infusion by filling tygon tubing with 40 ul of saline; cannula placement verified post mortem with cresyl violet staining; guide cannula used; obesity; endocrinology.

P9886 Wernicke,C., Hellmann,J., Zieba,B., Kuter,K., Ossowska,K., Frenzel,M., Dencher,N.A., Rommelspacher,H. 9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease. Pharmacological Reports 2010; 62(-1-):35-53. >>> MPP+; Saline; CSF/CNS; Rat; 2ML4; 42 days; Controls received mp w/vehicle or sham operation; long term study; animal info (male, wistar, 280-300 g).

Q0880 Zhu,X.H., Yan,H.C., Zhang,J., Qu,H.D., Qiu,X.S., Chen,L.A., Li,S.J., Cao,X.O., Bean,J.C., Chen,L.H., Qin,X.H., Liu,J.H., Bai,X.C., Mei,L., Gao,T.M. Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats. Journal of Neuroscience 2010; 30(-38-):12653-12663. >>> K252a; antibody, chicken anti-BDNF; antibody, chicken IgY; CSF, artificial; DMSO; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (3 mo old, Sprague Dawley, 180-220 g, male); 50% DMSO used; depression.

P9473 Anderson,G.M., Relf,H.L., Rizwan,M.Z., Evans,J.J. Central and Peripheral Effects of RFamide-Related Peptide-3 on Luteinizing Hormone and Prolactin Secretion in Rats. Endocrinology 2009; 150(-4-):1834-1840. >>> RF amide-related peptide-3; CSF, artificial; CSF/CNS; Rat; 1002; 2 weeks; ALZET brain infusion kit used; animal info (female, Sprague Dawley, 9-12 wks old, 250-300 g.); neuropeptide.

Q0220 Araki,S., Hirooka,Y., Kishi,T., Yasukawa,K., Utsumi,H., Sunagawa,K. Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method. HYPERTENSION RESEARCH 2009; 32(-12-):1091-1096. >>> RNH-6270; CSF, artificial; CSF/CNS; Rat; 2002; ; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, SHRSP, WKY, 11 wks old); RNH-6270 is an active form of olmesartan; cannula placement verified by post mortem injection of methylene blue.

Q0762 Bruel-Jungerman,E., Veyrac,A., Dufour,F., Horwood,J., Laroche,S., Davis,S. Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus. PLoS One 2009; 4(-11-):U52-U61. >>> LY294002; DMSO; CSF, artificial; CSF/CNS; Rat; 2004; ; Controls received mp w/ vehicle; animal info (young, male, adult, Sprague-Dawley, 10-12 wks old); enzyme inhibitor (Phosphoinositide 3-kinase, PI3K); post op. care (topical antiseptic, exocptoplix); behavioral testing (running wheel); 30% DMSO used; aCSF recipe.

P9622 Burgos-Ramos,E., Martos-Moreno,G.A., Lopez,M.G., Herranz,R., guado-Llera,D., Egea,J., Frechilla,D., Cenarruzabeitia,E., Leon,R., rilla-Ferreiro,E., Argente,J., Barrios,V. The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3-beta modulation. Journal of Neurochemistry 2009; 109(-2-):360-370. >>> Amyloid protein, beta (25-35); CSF/CNS; Rat; 2002; 14 days; Controls received mp w/saline; animal info (female, Wistar, 8 wks, OVX); neurodegenerative (Alzheimer's Disease); brain tissue distribution.

P9741 Burgos-Ramos,E., Puebla-Jimenez,L., rilla-Ferreiro,E. Minocycline prevents A-beta-(25-35)-induced reduction of somatostatin and neprilysin content in rat temporal cortex. LIFE SCIENCES 2009; 84(-7-8-):205-210. >>> Amyloid protein, beta (25-35); Acetic acid; CSF/CNS; Rat; 14 days; Controls received mp w/vehicle; peptides; animal info (male, Wistar, 200-250 g).

Q0394 Burgos-Ramos,E., Puebla-Jimenez,L., Hernandez-Pinto,A., rilla-Ferreiro,E. Sulfadiazine Partially Protects the Rat Temporal Cortex from Amyloid Beta Peptide (25-35)-Induced Alterations of the Somatostatinergic System. Neuroendocrinology 2009; 89(-4-):400-410. >>> Amyloid protein, beta (25-35); Acetic acid; CSF/CNS; Rat; 14 days; Controls received mp w/vehicle; animal info (male, Wistar, 200-250 g); peptides.

P9746 Catania,C., Sotiropoulos,I., Silva,R., Onofri,C., Breen,K.C., Sousa,N., Almeida,O.F.X. The amyloidogenic potential and behavioral correlates of stress. Molecular Psychiatry 2009; ;(-1-):95-105. >>> Amyloid protein, beta (1-40); Water, distilled; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/vehicle; functionality of mp verified; ALZET brain infusion kit used; peptides; animal info (male, Wistar, 14 months old); neurodegenerative (Alzheimer's disease); cannula patency verified.

P9561 Chan,S.H.H., Wu,K.L.H., Chang,A.Y.W., Tai,M.H., Chan,J.Y.H. Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension. Hypertension 2009; 53(-2-):217-U230. >>> Angiotensin II; phenylephrine; Saline; CSF, artificial; IP; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/vehicle; peptides; post op. care (Penicillin); animal info (SHR, 5-6 wks old, 11-12 wks old, Wky, 5-6 wks old).

Q0443 da Silva,A.A., do Carmo,J.M., Freeman,J.N., Tallam,L.S., Hall,J.E. A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin. Diabetes 2009; 58(-8-):1749-1756. >>> Leptin; SHU-9119; CSF/CNS; Rat; 2002; 10, 17 days; Animal info (male, Sprague-Dawley, 325-350 g); pumps replaced after 7 days; multiple pumps per animal (2); guide cannula used; cannula placement verified by angiotensin II dipsogenic effect; diabetes; Leptin and SHU-9119 attached to Y connector.

P9549 Dharap,A., Bowen,K., Place,R., Li,L.C., Vemuganti,R. Transient focal ischemia induces extensive temporal changes in rat cerebral MicroRNAome. Journal of Cerebral Blood Flow and Metabolism 2009; 29(-4-):675-687. >>> Antagomir-145; antagomir, control; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/control antagomir; ALZET brain infusion kit used; animal info (adult, male, SHR, MCAO).

Q0265 Gadjanski,I., Boretius,S., Williams,S.K., Lingor,P., Knoeferle,J., Saettler,M.B., Fairless,R., Hochmeister,S., Suehs,K.W., Michaelis,T., Frahm,J., Storch,M.K., Baehr,M., Diem,R. Role of N-Type Voltage-Dependent Calcium Channels in Autoimmune Optic Neuritis. Annals of Neurology 2009; 66(-1-):81-93. >>> Conotoxin, w-; CSF, artificial; CSF/CNS; Rat; 2004; 8, 23 days; Controls received mp w/ vehicle; animal info (female brown Norway, 8-10 wks old); functionality of mp verified by residual volume; w-conotixin is an N-type specific blocker.

P9562 Gonzalo-Gobernado,R., Reimers,D., Herranz,A.S., az-Gil,J.J., Osuna,C., Asensio,M.J., Baena,S., Rodriguez-Serrano,M., Bazan,E. Mobilization of Neural Stem Cells and Generation of New Neurons in 6-OHDA-lesioned Rats by Intracerebroventricular Infusion of Liver Growth Factor. JOURNAL OF HISTOCHEMISTRY&CYTOCHEMISTRY 2009; 57(-5-):491-502. >>> Liver growth factor, rat; Albumin, rat; saline; CSF/CNS; Rat; 2002; 15 days; Controls received mp w/vehicle; ALZET brain infusion kit used; animal info (female, Sprague Dawley, 220-250g); neurodegenerative (Parkinson's disease); behavioral testing (rotational behavior).

P9807 Guerra-Crespo,M., Gleason,D., Sistos,A., Toosky,T., Solaroglu,I., Zhang,J.H., Bryant,P.J., Fallon,J.H. TRANSFORMING GROWTH FACTOR-ALPHA INDUCES NEUROGENESIS AND BEHAVIORAL IMPROVEMENT IN A CHRONIC STROKE MODEL. Neuroscience 2009; 160(-2-):470-483. >>> Transforming growth factor; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ PBS; ALZET brain infusion kit used; animal info (90 days old, MCAO); behavioral testing (cylinder corner test).

P9513 Harvey,P.A., Lee,D.H.S., Qian,F., Weinreb,P.H., Frank,E. Blockade of Nogo Receptor Ligands Promotes Functional Regeneration of Sensory Axons after Dorsal Root Crush. Journal of Neuroscience 2009; 29(-19-):6285-6295. >>> Nogo receptor, soluble fragment; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; stability verified by "separate tests" (up to 1 month, pg 6286); ALZET brain infusion kit 2 used; peptides; animal info (male, Sprague Dawley, 200-250 g.); sNGR.

Q0951 Hashimoto,M., Hossain,S., Tanabe,Y., Kawashima,A., Harada,T., Yano,T., Mizuguchi,K., Shido,O. The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40). JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2009; 20(-12-):965-973. >>> Amyloid protein, beta (1-40); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (Wistar, 5 wks old); functionality of mp and cannula placement verified by examining brain slices; neurodegenerative (Alzheimer's disease).

P9342 Helena,C.V., McKee,D.T., Bertram,R., Walker,A.M., Freeman,M.E. The Rhythmic Secretion of Mating-Induced Prolactin Secretion Is Controlled by Prolactin Acting Centrally. Endocrinology 2009; 150(-7-):3245-3251. >>> S179D; Saline; CSF/CNS; Rat; 1003D; 3 days; Animal info (Sprague Dawley, 175-200 g., OVX); guide cannula used; S179D is a prolactin antagonoist.

P9823 Hu,S.X., Begum,A.N., Jones,M.R., Oh,M.S., Beech,W.K., Beech,B.H., Yang,F.S., Chen,P.P., Ubeda,O.J., Kim,P.C., Davies,P., Ma,Q.L., Cole,G.M., Frautschy,S.A. GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals. NEUROBIOLOGY OF DISEASE 2009; 33(-2-):193-206. >>> Amyloid protein, beta (1-42); lipoprotein, high density; CSF/CNS; Rat; 1004; 1 month; Controls received mp w/ HDL alone; animal info (male, Sprague Dawley, 19 months old); Plastics One cannula used; bilateral infusion; neurodegenerative (Alzheimer's Disease).

Q0044 Huang,B.S., Ahmad,M., Tan,J.H., Leenen,F.H.H. Chronic central versus systemic blockade of AT1 receptors and cardiac dysfunction in rats post-myocardial infarction. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-3-):H968-H975. >>> Losartan; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; animal info (Wistar, 200-250 g, MI); ischemia (cardiac); comparison of SC injections vs. mp.

P9413 Huang,B.S., White,R.A., Jeng,A.Y., Leenen,F.H.H. Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 296(-4-):R994-R1000. >>> FAD286 hydrogen tartrate; spironolactone; CSF, artificial; SC; CSF/CNS; Rat; 2002; 2004; 4 weeks; 19-20 days; Controls received mp w/ vehicle; dose-response (fig. 1); pumps replaced after 2 weeks; enzyme inhibitor (aldosterone synthase); cardiovascular; animal info (male, Dahl S, Dahl R, 5 wks old).

P9416 Isa,K., Garcia-Espinosa,M.A., Arnold,A.C., Pirro,N.T., Tommasi,E.N., Ganten,D., Chappell,M.C., Ferrario,C.M., Diz,D.I. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2) 27 hypertensive rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009; 297(-1-):R111-R115. >>> Antibody, rabbit anti-rat ANG (1-12); immunoglobulin G, rabbit; CSF, artificial; CSF/CNS; Rat (transgenic); 2ML2; 14 days; Controls received mp w/ IgG; functionality of mp verified by residual volume; no stress (see pg. R111, R112); stability verified by activity of agent in residual volume, 91-98% on day 13; antihypertensive; ALZET brain infusion 2 kit; animal info (male, (mRen2)27 Tg, 22-28 wks old, 550g.); cannula placement confirmed at end of each study.

Q0263 Jing,M., Shingo,T., Yasuhara,T., Kondo,A., Morimoto,T., Wang,F.F., Baba,T., Yuan,W.J., Tajiri,N., Uozumi,T., Murakami,M., Tanabe,M., Miyoshi,Y., Zhao,S.G., Date,I. The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting. Brain Research 2009; 1295(-;-):203-217. >>> Erythropoietin, human, recomb.; Saline; albumin, rat serum; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, 190-210 g).

P9496 Kadota,T., Shingo,T., Yasuhara,T., Tajiri,N., Kondo,A., Morimoto,T., Yuan,W.J., Wang,F.F., Baba,T., Tokunaga,K., Miyoshi,Y., Date,I. Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis. Brain Research 2009; 1254(-;-):120-127. >>> Erythropoietin; Albumin, rat serum; saline; CSF/CNS; Rat; 2001; 1 week; Controls received mp w/ vehicle; animal info (Sprague Dawley, 220-250 g.).

P9640 Kang,Y.M., Ma,Y., Zheng,J.P., Elks,C., Sriramula,S., Yang,Z.M., Francis,J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research 2009; 82(-3-):503-512. >>> Angiotensin II; losartan; pyrrolidine dithiocarbamate; tempol; Saline; CSF, artificial; IV (femoral); CSF/CNS; Rat; 4 weeks; Controls received mp w/vehicle; peptides; multiple pumps per animal (2); animal info (adult, male, Sprague-Dawley, 275-300g); bilateral cannula used for multiple drug infusions.

Q0294 Kang,Y.M., He,R.L., Yang,L.M., Qin,D.N., Guggilam,A., Elks,C., Yan,N., Guo,Z., Francis,J. Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure. Cardiovascular Research 2009; 83(-4-):737-746. >>> Pentoxifylline; etanercept; CSF, artificial; CSF/CNS; IP; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (Adult, male, Sprague-Dawley, 275-300 g).

Q0588 Keiner,S., Witte,O.W., Redecker,C. Immunocytochemical Detection of Newly Generated Neurons in the Perilesional Area of Cortical Infarcts After Intraventricular Application of Brain-Derived Neurotrophic Factor. Journal of Neuropathology and Experimental Neurology 2009; 68(-1-):83-93. >>> Brain-derived neurotrophic factor; NaCl; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (male, Wistar, 12-14 weeks, 250-300 g); functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; ischemia (focal cortical infarct); behavioral testing (the limb-use asymmetry; tapered beam walking; ladder rung walking); fig. 1c diagram of a parasagittal section of the rat brain showing cannula placement.

P9705 Kimura,T., Nguyen,P.T.H., Ho,S.A., Tran,A.H., Ono,T., Nishijo,H. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide. British Journal of Pharmacology 2009; 157(-3-):451-463. >>> Amyloid protein, beta (1-40); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 10 weeks; Controls received mp w/vehicle; long-term study; peptides; animal info (male, crj, Wistar, 7 wks old); behavioral testing (open field test).

Q0577 Kondo,A., Shingo,T., Yasuhara,T., Kuramoto,S., Kameda,M., Kikuchi,Y., Matsui,T., Miyoshi,Y., Agari,T., Borlongan,C.V., Date,I. Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Brain Research 2009; 1296(-;-):127-136. >>> Erythropoietin, human, recomb.; antibody, anti-EPO; Saline; CSF/CNS; Rat; 6 days; 24 hours; Controls received mp w/ rat serum albumin, or control mouse IgG; animal info (male, Fischer 344, 10-12 wks old, 200-250 g, SLC).

P9820 Lau,B.W.M., Yau,S.Y., Lee,T.M.C., Ching,Y.P., Tang,S.W., So,K.F. Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption. NeuroReport 2009; 20(-4-):371-377. >>> Ara-C; CSF/CNS; Rat; 3-13 days; Controls received mp w/ saline; no stress (see pg. 373); animal info (male, Sprague Dawley, 260-290 g.); behavioral testing (prepulse inhibition).

Q0514 Lee,C., Agoston,D.V. Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury. Experimental Neurology 2009; 220(-2-):400-403. >>> Vascular endothelial growth factor (164); SU5416; CSF, artificial; DMSO; CSF/CNS; Rat; 1002; 13 days; Controls received mp w/ vehicle; animal info (young, male, Sprague Dawley, 270-330 g.); cannula placement verified by histology; 1% DMSO used; artificial CSF recipe.

R0263 Merrill,J.E. In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination. Neuropsychopharmacology 2009; 34(-1-):55-73. >>> Antibody, anti-LINGO-1; Prolactin; CSF/CNS; intrathecal; SC; IP; Mice; rat; 2-3 weeks; Animal info (MOG-induced Experimental Autoimmune Encephalomyelitis).

P9355 Miller,A.M., Piazza,A., Martin,D.S.D., Walsh,M., Mandel,A., Bolton,A.E., Lynch,M.A. The deficit in long-term potentiation induced by chronic administration of amyloid-beta is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025. Experimental Gerontology 2009; 44(-4-):300-304. >>> Amyloid protein, beta (1-40); amyloid protein, beta (1-42); CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ amyloid protein, beta (40-1); ALZET brain infusion kit 2 used; post op. care (Rimadil); animal info (male, Wistar, 3-4 months old).

P9653 Miyamoto,N., Tanaka,R., Zhang,N., Shimura,H., Onodera,M., Mochizuki,H., Hattori,N., Urabe,T. CRUCIAL ROLE FOR Ser133-PHOSPHORYLATED FORM OF CYCLIC AMP-RESPONSIVE ELEMENT BINDING PROTEIN SIGNALING IN THE DIFFERENTIATION AND SURVIVAL OF NEURAL PROGENITORS UNDER CHRONIC CEREBRAL HYPOPERFUSION. Neuroscience 2009; 162(-2-):525-536. >>> H7; Saline; CSF/CNS; Rat; 1002; 7 days; Controls received mp w/vehicle; animal info (adult, male, wistar, 9 wks, 250-270); H7 is a novel PKA/PKC inhibitor; ALZET brain infusion kit used.

P9843 Oya,S., Yoshikawa,G., Takai,K., Tanaka,J.I., Higashiyama,S., Saito,N., Kirino,T., Kawahara,N. ATTENUATION OF Notch SIGNALING PROMOTES THE DIFFERENTIATION OF NEURAL PROGENITORS INTO NEURONS IN THE HIPPOCAMPAL CA1 REGION AFTER ISCHEMIC INJURY. Neuroscience 2009; 158(-2-):683-692. >>> Epidermal growth factor, recomb. human; fibroblast growth factor, recomb. human; Jag1, recomb. rat; S2188; DLL4, recomb. mouse; CSF, artificial, DMSO; CSF/CNS; Rat; 1003D; 1007D; 11 days; Controls received mp w/ vehicle; pumps replaced after 3 days; enzyme inhibitor (gamma secretase); animal info (male, Wistar, adult, 8 wks old, 280-320 g.); ischemia (cerebral); bilateral infusion; 10% DMSO used; brain tissue distribution.

Q0939 Park,S., Hong,S.M., Ahn,I.S. Long-Term Intracerebroventricular Infusion of Insulin, but Not Glucose, Modulates Body Weight and Hepatic Insulin Sensitivity by Modifying the Hypothalamic Insulin Signaling Pathway in Type 2 Diabetic Rats. Neuroendocrinology 2009; 89(-4-):387-399. >>> Insulin; glucose; CSF/CNS; Rat; 4 weeks; Controls received mp w/ artificial CSF; animal info (Sprague-Dawley, male, 215 g); one group contained insulin + glucose; pump implanted after 1 week recovery period.

Q0258 Pathipati,P., Surus,A., Williams,C.E., Scheepens,A. Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat. Behavioural Brain Research 2009; 204(-1-):93-101. >>> Growth hormone, rat; NaCl; Tween 20; NaHCO3; Na2CO3; CSF/CNS; Rat; 2002; 6 weeks; Controls received mp w/ vehicleanimal info (adult, male, Sprague-Dawley, 280-350 g); pumps replaced every 2 weeks; stability verified by for 2 weeks in vitro.

Q0566 Peng,Y., Xing,C.H., Xu,S.F., Lemere,C.A., Chen,G.Q., Liu,B., Wang,L., Feng,Y.P., Wang,X.L. L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. European Journal of Pharmacology 2009; 621(-1-3-):38-45. >>> Amyloid protein, beta (1-40); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 17 days; Controls received mp w/ vehicle; animal info (3 mo old, male, Wistar, 280-300 g); neurodegenerative (Alzheimer's disease).

Q0570 Petersen,P.S., Woldbye,D.P.D., Madsen,A.N., Egerod,K.L., Jin,C.Y., Lang,M., Rasmussen,M., Beck-Sickinger,A.G., Holst,B. In Vivo Characterization of High Basal Signaling from the Ghrelin Receptor. Endocrinology 2009; 150(-11-):4920-4930. >>> Substance P; PBS; BSA; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle or inactive control peptide; animal info (Male Wistar, 275-300 g, STZ induced diabetes); peptides.

Q0384 Quesada,A., Micevych,P., Handforth,A. C-terminal mechano growth factor protects dopamine neurons: A novel peptide that induces heme oxygenase-1. Experimental Neurology 2009; 220(-2-):255-266. >>> Mechano growth factor 24; JB1; CSF, artificial; CSF/CNS; SC; Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (adult, Long-Evans, male, 225-250 g); peptides; JB1 is an IGF-1 analog.

Q0571 Roa,J., Garcia-Galiano,D., Varela,L., Sanchez-Garrido,M.A., Pineda,R., Castellano,J.M., Ruiz-Pino,F., Romero,M., Aguilar,E., Lopez,M., Gaytan,F., Dieguez,C., Pinilla,L., Tena-Sempere,M. The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System. Endocrinology 2009; 150(-11-):5016-5026. >>> Leucine, L-; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (Wistar, female); immunology.

Q0691 Salome,N., Hansson,C., Taube,M., Gustafsson-Ericson,L., Egecioglu,E., Karlsson-Lindahl,L., Fehrentz,J.A., Martinez,J., Perrissoud,D., Dickson,S.L. On the Central Mechanism Underlying Ghrelin's Chronic Pro-Obesity Effects in Rats: New Insights from Studies Exploiting a Potent Ghrelin Receptor Antagonist. Journal of Neuroendocrinology 2009; 21(-9-):777-785. >>> Ghrelin, human; JMV2959; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 250-300 g); JMV2959 is a ghrelin receptor antagonist; obesity.

Q0433 Sangiao-Alvarellos,S., Vazquez,M.J., Varela,L., Nogueiras,R., Saha,A.K., Cordido,F., Lopez,M., Dieguez,C. Central Ghrelin Regulates Peripheral Lipid Metabolism in a Growth Hormone-Independent Fashion. Endocrinology 2009; 150(-10-):4562-4574. >>> Ghrelin; Saline; CSF/CNS; Rat; 2001D; 2ML2; 8 days; Controls received mp w/ vehicle; animal info (male, wt, GH-def, Lewis, 2-3 months old, 222 g); endocrinology.

Q0576 Serbedzija,P., Madl,J.E., Ishii,D.N. Insulin and IGF-I prevent brain atrophy and DNA loss in diabetes. Brain Research 2009; 1303(-;-):179-194. >>> Insulin; insulin-like growth factor-I; CSF/CNS; Rat; 12 weeks; Controls received mp w/ aCSF; animal info (Wistar, 275-300 g adult, 9 wks old, male, STZ-induced diabetes); long-term study; pumps replaced at two week intervals; ALZET brain infusion kit used; post op. care (Buprenorphine); cannula placement verified by injecting 20 ul dye through the catheter at time of assay.

P9689 Srivareerat,M., Tran,T.T., Alzoubi,K.H., Alkadhi,K.A. Chronic Psychosocial Stress Exacerbates Impairment of Cognition and Long-Term Potentiation in beta-Amyloid Rat Model of Alzheimer's Disease. Biological Psychiatry 2009; 65(-11-):918-926. >>> Amyloid protein, beta (1-40); amyloid protein, beta (1-42); Water, distilled; acetonitrile; trifluoroacetate; CSF/CNS; Rat; 2 weeks; Controls received mp w/ inactive reverse peptide, amyloid protein beta (40-1); post op. care (antibiotic ointment); animal info (male, Wistar, 200-225 g.); neurodegenerative (Alzheimer's Disease).

P9583 Sumner,J.P., Shapiro,E.M., Maric,D., Conroy,R., Koretsky,A.P. In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: Quantification of labeled cell phenotype. NEUROIMAGE 2009; 44(-3-):671-678. >>> Ara-C; CSF/CNS; Rat; 2002; 2 weeks; Animal info (6 wks old, Sprague-Dawley).

P9669 Sun,D, Bullock,M.R., McGinn,M.J., Zhou,Z., Altememi,N., Hagood,S., Hamm,R, Colello,R.J. Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury. Experimental Neurology 2009; 216(-1-):56-65. >>> Fibroblast growth factor, b- recomb. human; CSF, artificial; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; animal info (male, Sprague Dawley, 3 months old, 300 g.).

P9806 Tang,H.D., Wang,Y.M., Xie,L., Mao,X.O., Won,S.J., Galvan,V., Jin,K.L. Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after focal ischemia. NEUROBIOLOGY OF AGING 2009; 30(-2-):299-308. >>> Z-DEVD-FMK; DMSO; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; enzyme inhibitor (peptide methylketone caspase-3); animal info (5 days old, 3, 11, 24, months old, Fischer 344); brain tissue distribution.

P9709 Thompson,E.L., Amber,V., Stamp,G.W.H., Patterson,M., Curtis,A.E., Cooke,J.H., Appleby,G.F., Dhillo,W.S., Ghatei,M.A., Bloom,S.R., Murphy,K.G. Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. British Journal of Pharmacology 2009; 156(-4-):609-625. >>> Kisspeptin-54; Saline; SC; CSF/CNS; Rat; 2001D; 2001; 1, 2, 3 days; 6, 12, 24 hours; Controls received mp w/vehicle; functionality of mp verified; peptides; animal info (adult, male, Wistar, 275-325 g.).

Q0767 Traub,M.L., De Butte-Smith,M., Zukin,R.S., Etgen,A.M. Oestradiol and Insulin-Like Growth Factor-1 Reduce Cell Loss after Global Ischaemia in Middle-Aged Female Rats. Journal of Neuroendocrinology 2009; 21(-12-):1038-1044. >>> Insulin-like growth factor-I; Saline, sterile; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 9-11 mo old, adult, 300-500 g); functionality of mp verified by residual volume; ALZET brain infusion kit used; cannula placement verified by inspection of cryostat sectioning; neuroprotection.

Q0659 Tsai,Y.J., Lin,C.T., Huang,C.T., Wang,H.Y., Tien,L.T., Chen,S.H., Lue,J.H. Neuropeptide Y Modulates c-Fos Protein Expression in the Cuneate Nucleus and Contributes to Mechanical Hypersensitivity following Rat Median Nerve Injury. Journal of Neurotrauma 2009; 26(-9-):1609-1621. >>> Neuropeptide Y, neuropeptide y antagonist; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 180-250 g); functionality of mp verified by residual volume.

Q0789 Upadhya,M.A., Dandekar,M.P., Kokare,D.M., Singru,P.S., Subhedar,N.K. Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: Behavioral and neuroanatomical correlates. Neuropeptides 2009; 43(-4-):303-314. >>> Morphine; CSF/CNS; Rat; 2001; 8 days; Animal info (adult, male, Sprague-Dawley, 230-250 g); tolerance; behavioral testing (thermal paw withdrawal test); guide cannula used.

Q0626 Wang,X.M., Mao,X.O., Xie,L., Greenberg,D.A., Jin,K.L. Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. Journal of Cerebral Blood Flow and Metabolism 2009; 29(-10-):1644-1654. >>> Antibody, notch1-activating; antibody, Jagged-Fc-anti-Fc; antibody, anti-Fc; DAPT; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 280-310 g); enzyme inhibitor (gamma secretase); middle cerebral artery occlusion (MCAO); DAPT also known as (N-[N-(3,5-difluorophenacetyl)-L-alanyl]S-phenylglycine t-butyl ester).

P9459 Wei,S.G., Yu,Y., Zhang,Z.H., Felder,R.B. Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-5-):H1425-H1433. >>> Angiotensin II; losartan; PD-98059; SP-600125; SB-203580; Saline; DMSO; CSF, artificial; SC; CSF/CNS; Rat; 2002; 2004; 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; enzyme inhibitor (MAP kinase, Jun N-terminal kinase); cardiovascular; peptides; multiple pumps per animal (2); animal info (male, Sprague Dawley, 275-300 g.); cannula placement confirmed at end of study; 0.1%-0.5% DMSO used.

P9462 White,C.L., Whittington,A., Barnes,M.J., Wang,Z., Bray,G.A., Morrison,C.D. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2009; 296(-2-):E291-E299. >>> Leptin; Saline; SC; CSF/CNS; Rat; mice; 10, 14 days; Controls received mp w/ vehicle; comparison of IP, ICV injections vs. mp; peptides; post op. care (analgesics); animal info (male, Long Evans, 10 wks old; C57BL/6 wt, ob/ob, 8 wks old).

P9577 Wright,J.W., Meighan,P.C., Brown,T.E., Wiediger,R.V., Sorg,B.A., Harding,J.W. Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3. Behavioural Brain Research 2009; 203(-1-):27-34. >>> MMP-3i; CSF/CNS; Rat; 2001; 6 days; Controls received mp aCSF; functionality of mp verified by residual volume; animal info (male, Sprague Dawley, 300-350g); behavioral testing (head-shake response habituation); cannula placement verified w/icv injection of fast green dye; enzyme inhibitor (metalloproteinase-3).

P9654 Wu,J.S., Cheung,W.M., Tsai,Y.S., Chen,Y.T., Fong,W.H., Tsai,H.D., Chen,Y.C., Liou,J.Y., Shyue,S.K., Chen,J.J., Chen,Y.E., Maeda,N., Wu,K.K., Lin,T.N. Ligand-Activated Peroxisome Proliferator-Activated Receptor-gamma; Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3 Upregulation. Circulation 2009; 119(-8-):1124-1134. >>> Peroxisome proliferator-activated receptor, gamma; RNA, small interfering; DMSO; CSF/CNS; Rat; 1007D; 72 hours; Controls received mp w/vehicle; ALZET brain infusion kit 2 used; cyanoacrylate adhesive; schemia; 14-3-3 epsilon siRNA.

P9467 Xue,B.J., Badaue-Passos,D.Jr, Guo,F., Gomez-Sanchez,C.E., Hay,M., Johnson,A.K. Sex differences and central protective effect of 17 beta-estradiol in the development of aldosterone/NaCl-induced hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-5-):H1577-H1585. >>> Aldosterone; estradiol, 17b-; ICI 182,780; SC; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy, castration); cardiovascular; multiple pumps per animal (2); animal info (male, Sprague Dawley, 10-12 wks old); cannula placement verified histologically; estrogen receptor antagonist; endocrinology.

P9739 Zai,L.L., Ferrari,C., Subbaiah,S., Havton,L.A., Coppola,G., Strittmatter,S., Irwin,N., Geschwind,D., Benowitz,L.I. Inosine Alters Gene Expression and Axonal Projections in Neurons Contralateral to a Cortical Infarct and Improves Skilled Use of the Impaired Limb. Journal of Neuroscience 2009; 29(-25-):8187-8197. >>> Inosine; Saline; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/vehicle; post op. care (buprenex); animal info (adult, Sprague Dawley, 275-300 g); behavioral testing (forelimb reaching).

Q0296 Zhang,J.J., Scarpace,P.J. The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo. British Journal of Pharmacology 2009; 158(-2-):475-482. >>> Soluble leptin receptor; leptin; CSF, artificial; saline; CSF/CNS; SC; Rat; 2001; 3 weeks; Controls received mp w/ vehicle; animal info (2 mo-old, male, F344 x Brown Norway); ALZET brain infusion kit used; pumps replaced after after 2 weeks; 2 week aCSF delayed infusion; aCSF pump was replaced with SLR pump plus leptin pump after 2 weeks.

P9767 Zhang,Q., Chen,C., Lue,J.G., Xie,M.J., Pan,D.J., Luo,X., Yu,Z.Y., Dong,Q., Wang,W. Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1-beta, MIP-1-alpha, and NO After Focal Cerebral Ischemia in the Rat. Glia 2009; 57(-8-):908-920. >>> Roscovitine; DMSO; saline; CSF/CNS; Rat; 2001; ; Controls received mp w/vehicle; functionality of mp verified by "weighing the cassette before placement and after the experiment" pg. 909; enzyme inhibitor (cyclin dependant kinase); ALZET brain infusion kit used; ischemia (cerebral); animal info (adult, male, Sprague Dawley, 220-270 g); 0.2% DMSO used; MCAO.

P9968 Zhang,Q., Yao,F.R., O'Rourke,S.T., Qian,S.Y., Sun,C.W. Angiotensin II enhances GABAB receptor-mediated responses and expression in nucleus tractus solitarii of rats. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-5-):H1837-H1844. >>> Angiotensin II; CSF/CNS; Rat; 2004; 7 days; Controls received mp w/ aCSF; peptides; cardiovascular; ALZET brain infusion kit 2 used; animal info (male, Sprague-Dawley, 290-350 g); functionality of mp verified by mean arterial BP.