References on the Intracerebroventricular Administration of Agents to Rats Using ALZET® Osmotic Pumps

16287 de Kloet, A. D., Pitra, S., Wang, L., Hiller, H., Pioquinto, D. J., Smith, J. A., Sumners, C., Stern, J. E., Krause, E. G. Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice. Endocrinology 2016; 157(-8-):3167-80. >>> Compound 21; CSF, artificial; Saline; CSF/CNS (lateral ventricle); Mice, rats; Controls received mp w/ vehicle; animal info (Male mice (10–12 wk old) or rats (4–6 wk old)); functionality of mp verified by plasma vasopressin levels; ALZET brain infusion kit used; ALZET brain infusion kit used; Brain coordinates; from bregma 0.2 mm posterior, 1.0 mm lateral, and 2.5 mm ventral; Dose (7.5 ng/kg/hr);.

16257 Ahl, M., Avdic, U., Skoug, C., Ali, I., Chugh, D., Johansson, U. E., Ekdahl, C. T. Immune response in the eye following epileptic seizures. J Neuroinflammation 2016; 13(-1-):155. >>> Antibody, CX3CR1; saline; CSF/CNS (ventricle); rat; Controls were Electrode- and cannulae-implanted nonstimulated rats; animal info (Adult male Sprague Dawley rats, 200-250 g); functionality of mp verified by EEG; functionality of mp verified by EEG; brain tissue distribution; Cannula placement verified via expression of antibody; Dose (1 mm posterior and 1.5 mm lateral to the bregma and 3.5 mm ventral to the flat skull position (with the bregma as reference)); Interesting“Our results are the first evidence that epileptic seizures induce an immune response in the retina. It has a potential to become a novel non-invasive tool for detecting brain inflammation through the eyes” pg. 1;.

16229 Perianes-Cachero, A., Canelles, S., Aguado-Llera, D., Frago, L. M., Toledo-Lobo, M. V., Carrera, I., Cacabelos, R., Chowen, J. A., Argente, J., Arilla-Ferreiro, E., Barrios, V. Reduction in Abeta-induced cell death in the hippocampus of 17beta-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone. J Neurochem 2015; 135(-6-):1257-71. >>> Amyloid protein, beta (25-35); ICI 182,780; saline; CSF/CNS (right cerebral ventricle); rat; 2002; Controls received mp w/ vehicle; animal info (female Wistar rats, 8 weeks); brain infusion kit used; peptides; Amyloid beta-peptide induces cell death, learning and memory, hippocampal somatostatinergic system; Dose (300 pmol/day (A-beta), 600 fmol/day (ICI)); Brain coordinates; (-0.3 mm anteroposterior, 1.1 mm lateral).

16209 McMillin, M., Frampton, G., Quinn, M., Divan, A., Grant, S., Patel, N., Newell-Rogers, K., DeMorrow, S. Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling. Mol Endocrinol 2015; 29(-12-):1720-30. >>> Oligonucleotide, Vivo-morpholino; CSF/CNS (lateral ventricle); rat; Controls received mp w/ vehicle; brain infusion kit used; brain tissue distribution; Dose (1 mg/kg / d);.

16196 Lee, Chun-Lin, Lin, Pei-Ying, Hsu, Ya-Wen, Pan, Tzu-Ming  Journal of Functional Foods 2015; 18(--):387-399. >>> Amyloid protein, beta (40); Acetonitrile, trifluoroacetic acid; CSF/CNS (left ventricle); rat; 2004; Controls received mp w/ vehicle; animal info: Male Sprague Dawley (SD) rats at 6–8 weeks; functionality of mp verified by behavior tests; 35% acetonitrile, 0.1% trifluoroacetic acid; dose-response (pg 390); behavioral testing (Morris water maze; reference memory task, probe test, and working memory task); brain tissue distribution; peptides; cannula was inserted 4.0 mm into the left ventricle and attached to the skull with dental cement; Dose: 0.28 uL/h.

16181 Stephanie R. Sisley,, Deanna M. Arble,, Adam P. Chambers,, Ruth Gutierrez-Aguilar,, Yanlin He,, Yong Xu,, David Gardner,, David D. Moore,, Randy J. Seeley,, Darleen A. Sandoval  Diabetes 2016; (--):1-35. >>> Vitamin D3, 1,25-dyhydroxy; Cyclodextrin; hydroxypropyl-B-; CSF/CNS (third ventricle); Rat; 1004; Controls received mp w/ vehicle; animal info (male, Long Evans, adult); dose-response (Supplementary Figure 3); obesity; Dose (-.264 ug/day); Brain coordinates (i3vt 2.2A/P, 7.8D/V);.

16045 Toklu, H. Z., Bruce, E. B., Sakarya, Y., Carter, C. S., Morgan, D., Matheny, M. K., Kirichenko, N., Scarpace, P. J., Tumer, N. Anorexic response to rapamycin does not appear to involve a central mechanism. Clin Exp Pharmacol Physiol 2016; 43(-9-):802-7. >>> Rapamycin; DMSO; PEG 400; CSF/CNS (third ventricle); Rat; Controls received mp w/ vehicle; animal info (male, F344 Brown Norway, 23-25 months old); 10% DMSO used; used PE-50 tubing; pumps initially filled with aCSF - after one week recovery, pumps replaced with rapamycin or vehicle pump; Dose (30 ug/day); Brain coordinates (1.1 mm posterior to Bregma and 1.6 mm ventral from the skull surface on the midline (medial s- sure), with the nose bar set at 4 mm below the ear bars (below zero)) pg 805;.

15901 Zhou, T. F., Yu, J. G. Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. J Surg Res 2013; 183(-1-):304-12. >>> rhEPO; PBS, BSA; CSF/CNS (left lateral ventricle); rat; animal info: Sprague-Dawley; neurodegenerative (septic encephalopathy); behavioral testing (Morris Water Maze); mp used to infuse rhEPO to study its effect on septic encephalopathy. Application of rhEPO improved skeletal muscle microcirculation and tissue bioenergetics in septic mice. rhEPO improved neuronal apoptosis, and hippocampus-dependent cognitive impairments in a septic model; dose: 5 U/d;.

15734 Hannah Botfield,, Ana Maria Gonzalez,, Osama Abdullah,, Anders Dæhli Skjolding,, Martin Berry,, James Pat McAllister,, and Ann Logan  Brain 2013; (-136-):2842-2858. >>> decorin, human recombinant; PBS; CSF/CNS (right lateral ventricle); rat; 2002; controls received mp w/ vehicle; 3 wk old, Sprague-Dawley rats; mp were used to infuse decorin to suppress the inflammatory response in the subarachnoid space following a hemorrhage, and to prevent ventriculomegaly; MRI; dose 5 mg/ml.

15731 Robert W. Regenhardt,, Adam P. Mecca,, Fiona Desland,, Phillip F. Ritucci-Chinni,, Jacob A. Ludin,, David Greenstein,, Cristina Banuelos,, Jennifer L. Bizon,, Mary K. Reinhard, and Colin Sumners  Experimental Physiology 2014; 99(-2-):442-453. >>> Angiotensin (1-7); A779; CSF, artificial; CSF/CNS (left lateral cerebral ventricle); rat; 2006; Controls received mp w/ vehicle; animal info; Male spSHRs, treated until 91 days old (~248 g); ALZET brain infusion kit 1 used; ischemia (ischaemic stroke in the brain); behavioral testing (sunflower seed-eating task to determine fine motor function and neurological deficits); long-term study 6 weeks; peptides delivered; A779 aka (D-Ala7)-Ang-(1–7); Dose: Ang-(1–7) (1.0Ǩg in 0.15Ǩl ACSF h−1);(D-Ala7)-Ang-(1–7) (A779; 2.5Ǩg in 0.15Ǩl ACSF h−1).

15273 Hannah Botfield,, Ana Maria Gonzalez,, Osama Abdullah,, Anders Dæhli Skjolding,, Martin Berry,, James Pat McAllister II,, Ann Logan  Brain, A Journal of Neurology 2013; 136(--):2842-2858. >>> human recombinant decorin; PBS; CSF/CNS (right lateral ventricle); rat; 2002; MRI; controls received mp w/ vehicle; 3 wk old, Sprague-Dawley rats; dose: 5 mg/ml; mp were used to infuse decorin to suppress the inflammatory response in the subarachnoid space following a hemorrhage, and to prevent ventriculomegaly..

15237 Vaill, M.I., Desai, B.N., Harris, R.B.S. Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2014; 306(-4-):E414-E423. >>> Leptin, rat recombinant; PBS; CSF/CNS (third ventricle); Rat; 1002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley); brain coordinates;.

15220 Koneru, B., Bathina, C.S., Cherry, B.H., Mifflin, S.W. Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2014; 306(-1-):R61-R66. >>> Aldosterone; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Animal info (Wistar-Kyoto, 275g); tissue perfusion (fourth ventricle); cardiovascular;.

15121 Trivedi, C., Shan, X.Y., Tung, Y.C.L., Kabra, D., Holland, J., Amburgy, S., Heppner, K., Kirchner, H., Yeo, G.S.H., Perez-Tilve, D., Perez-Tilve, D. Tachykinin-1 in the Central Nervous System Regulates Adiposity in Rodents. ENDOCRINOLOGY 2015; 156(--):1714-1723. >>> Ghrelin; neuropeptide K; Saline; CSF/CNS (fourth ventricle); CSF/CNS; Rat; mice; 1002;1007D; Controls received mp w/ vehicle; animal info (rat male, Wistar, 260-290g; mice male, C57Bl6, 12-16 weeks old); ALZET brain infusion kit used; dose-response (pg 1718); post op. care (analgesics); behavioral testing (locomotor activity); neuropeptide K aka NPK;.

14921 do Carmo, J.M., da Silva, A.A., Hall, J.E., do Carmo, J.M. Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats. JOURNAL OF HYPERTENSION 2015; 33(--):1201-1206. >>> SHU-9119; CSF/CNS (fourth ventricle); Rat; 2002; Animal info (male, Spontaneously hypertensive or Wistar-Kyoto, 275-325g, 15-17 weeks old); behavioral testing (food intake); tissue perfusion (fourth ventricle); cardiovascular; Cannula placement verified via Evan's Blue dye; bp measured using radiotelemetry (DSI);.

14474 Wang, Y.K., Shen, D., Hao, Q., Yu, Q., Wu, Z.T., Deng, Y., Chen, Y.F., Yuan, W.J., Hu, Q.K., Su, D.F., Wang, W.Z., Wang, W.Z. Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 2014; 307(--):H182-H190. >>> A779; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, SHR and WKY); tissue perfusion (fourth ventricle);.

14318 Neal-Perry, G., Yao, D.C., Shu, J., Sun, Y., Etgen, A.M., Neal-Perry, G. Insulin-Like Growth Factor-I Regulates LH Release by Modulation of Kisspeptin and NMDA-Mediated Neurotransmission in Young and Middle-Aged Female Rats. Endocrinology 2014; 155(--):1827-1837. >>> JB-1; insulin-like growth factor-1;; CSF, artificial; CSF/CNS (third ventricle); Rat; 2002; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 3-4 months or 9-11 months old, ovariectomized); peptides; cannula placement verified via dye infusion; used Plastics One cannula; JB-1 is a selective antagonist of IGF-Ir;.

14222 Hopp, S.C., D'Angelo, H.M., Royer, S.E., Kaercher, R.M., Crockett, A.M., Adzovic, L., Wenk, G.L., Wenk, G.L. Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U1-U14. >>> Endotoxin, LPS; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ aCSF; animal info (male F-344, 3 months old); neurodegenerative (Alzheimer's disease); behavioral testing (Morris Water Maze); immunology;.

14221 Hopp, S.C., Royer, S.E., D'Angelo, H.M., Kaercher, R.M., Fisher, D.A., Wenk, G.L., Wenk, G.L. Differential Neuroprotective and Anti-Inflammatory Effects of L-Type Voltage Dependent Calcium Channel and Ryanodine Receptor Antagonists in the Substantia Nigra and Locus Coeruleus. Journal of Neuroimmune Pharmacology 2015; 10(--):35-44. >>> Endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Animal info (male, F-344, 3 months old); behavioral testing (rotarod; open field test; forced swim test); tissue perfusion (fourth ventricle); immunology;.

14709 Desai, B.N., Harris, R.B.S., Harris, R.B.S. Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2015; 308(--):E351-E361. >>> Leptin; CSF/CNS (third ventricle; fourth ventricle); Rat; 2002; Controls received mp w/ saline; animal info (male, Sprague Dawley, 275-300g); Multiple pumps per animal (2); tissue perfusion (third ventricle; fourth ventricle); bilateral infusion; one cannula to third ventricle second cannula to fourth ventricle; used plastics one cannula;.

14650 Adzovic, L., Lynn, A.E., D'Angelo, H.M., Crockett, A.M., Kaercher, R.M., Royer, S.E., Hopp, S.C., Wenk, G.L., Wenk, G.L. Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. Journal of Neuroinflammation 2015; 12(--):U1-U10. >>> Insulin, recombinant cat; endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (male, F-344, 3 months old, 21 months old); bilateral cannula used; behavioral testing (morris water maze); tissue perfusion (fourth ventricle); bilateral infusion; used tygon tubing to attach cannula to pump;.

14647 Van Kummer, B.H., Cohen, R.W., Cohen, R.W. Exercise-Induced Neuroprotection in the Spastic Han Wistar Rat: The Possible Role of Brain-Derived Neurotrophic Factor. BIOMED RESEARCH INTERNATIONAL 2015; ;(--):U1-U11. >>> K252a; DMSO; saline; CSF/CNS (third ventricle); Rat; 2004; Control animals received mp w/ vehicle; animal info (spastic, Han Wistar, 28 days old); 1% DMSO used.

14646 Tan, C.C., Zhang, J.G., Tan, M.S., Chen, H., Meng, D.W., Jiang, T., Meng, X.F., Li, Y., Sun, Z., Li, M.M., Yu, J.T., Tan, L., Yu, J.T. NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model. Journal of Neuroinflammation 2015; 12(--):U1-U12. >>> RNA, small interfering; CSF/CNS (third ventricle); Rat; 2006; Control animals received mp w/ control siRNA in aCSF; animal info (Sprague Dawley, 260-300 g); long-term study;.

14640 Meng, X.F., Tan, L., Tan, M.S., Jiang, T., Tan, C.C., Li, M.M., Wang, H.F., Yu, J.T., Tan, L. Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus. Journal of Neuroinflammation 2014; 11(--):U1-U12. >>> RNA, small interfering; CSF/CNS (third ventricle); Rat; 2006; Control animals received mp w/ aCSF; animal info (adult, male, Sprague Dawley, 260-300 g); long-term study;.

13856 Ma, J.H., Choi, B.R., Chung, C., Min, S.S., Jeon, W.K., Han, J.S., Han, J.S. Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus. MOLECULAR BRAIN 2014; 7(--):U1-U10. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Fischer-344); behavioral testing (morris water maze); tissue perfusion (fourth ventricle); immunology; LPS from E.coli, serotype 055:B5;.

13723 Brothers, H.M., Bardou, I., Hopp, S.C., Kaercher, R.M., Corona, A.W., Fenn, A.M., Godbout, J.P., Wenk, G.L. Riluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of Glutamate Transporters and Spatial Memory. Journal of Neuroimmune Pharmacology 2013; 8(-5-):1098-1105. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (Fisher F-344, 3 months old); behavioral testing (Morris water maze); tissue perfusion (fourth ventricle); immunology;.

13714 Bardou, I., Kaercher, R.M., Brothers, H.M., Hopp, S.C., Royer, S., Wenk, G.L. Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem. NEUROBIOLOGY OF AGING 2014; 35(-5-):1065-1073. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2006; Controls received mp w/ vehicle; animal info (male, F-344 rats, 3 months or 9 months or 23 months old); post op. care (lidocane 1% on wound; 2ML isotonic saline SC injection; 2% tylenol in drinking water 3 days after surgery); tissue perfusion (fourth ventricle); long-term study; immunology; LPS aka lipopolysaccharide;.

13382 Helfer, G., Ross, A.W., Morgan, P.J. Neuromedin U Partly Mimics Thyroid-Stimulating Hormone and Triggers Wnt/beta-Catenin Signalling in the Photoperiodic Response of F344 Rats. Journal of Neuroendocrinology 2013; 25(-12-):1264-1272. >>> Thyroid stimulating hormone, bovine; Saline; CSF/CNS (third ventricle); Rat; 1002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10-11 weeks old); stress/adverse reaction: (see pg.1270); Cannula placement verified via dye administration; thyroid stimulating hormone, bovine aka bTSH; 22g Plastics One cannula used.

13351 Beall, C., Haythorne, E., Fan, X.N., Du, Q.Y., Jovanovic, S., Sherwin, R.S., Ashford, M.L.J., McCrimmon, R.J. Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro. Diabetologia 2013; 56(-9-):2088-2092. >>> NN414; CSF/CNS (third ventricle); Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley); ALZET brain infusion kit used; channel opener for SUR1/Kir6.2 subtype of the ATP-sensitive potassium channel.

13350 Bardou, I., Brothers, H.M., Kaercher, R.M., Hopp, S.C., Wenk, G.L. Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus. NEUROBIOLOGY OF AGING 2013; 34(-10-):2293-2301. >>> Endotoxin, LPS; Cerebrospinal fluid, artificial; CSF/CNS (fourth ventricle); Rat; 2006; Controls received mp w/ vehicle; animal info (male, F-344, 3 months, 9 months, and 23 months of age); post op. care (1% lidocane to closure, saline injected SC); behavioral testing (Morris Water Maze); used Tygon tubing.

13234 Harris, R.B.S. Leptin-induced increase in body fat content of rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013; 304(-3-):E267-E281. >>> Leptin; mutein; PBS; CSF/CNS (fourth ventricle); IP; Rat; 1002; 2002; Controls received mp w/ PBS, or saline; animal info (male, sprague dawley, 320-350 g); central administration of leptin through 4th ventricle, and effect on body fat mass; 0.15 ug leptin/24 hr, or 0.6 ug leptin/24 hr; 4th ventricle; multiple pumps (2).

13142 Desai, B.N., Harris, R.B.S. Integrated Effects of Leptin in the Forebrain and Hindbrain of Male Rats. Endocrinology 2013; 154(-8-):2663-2675. >>> Leptin; Saline; CSF/CNS (third ventricle); CSF/CNS (fourth ventricle); Rat; 2002; Control animals received mp w/ saline; animal info (Sprague Dawley, male); Plastics One cannula used.

13013 Kellom, M., Basselin, M., Keleshian, V.L., Chen, M., Rapoport, S.I., Rao, J.S. Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammation. BMC NEUROSCIENCE 2012; 13(-;-):U1-U11. >>> Endotoxin, E. coli; CSF/CNS (fourth ventricle); Rat; 2002; Control animals received mp w/ aCSF; animal info (3 mo old, male, F344 Fischer); post op. care (triple antibiotic ointment, saline injection).

12800 Formenti, S., Bassi, M., Nakamura, N.B., Schoorlemmer, G.H.M., Menani, J.V., Colombari, E. Hindbrain mineralocorticoid mechanisms on sodium appetite. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2013; 304(-3-):R252-R259. >>> Aldosterone; Saline; ethanol; CSF/CNS; CSF/CNS (fourth ventricle); Rat; 2001; Control animals received mp w/ vehicle; animal info (Wistar Hannover, male, 280-350 g); guide cannula used; infusion rate incorrectly listed as 2 ul/hr; 1% ethanol used; dose response (table 1);.

12729 Cerbai, F., Lana, D., Nosi, D., Petkova-Kirova, P., Zecchi, S., Brothers, H.M., Wenk, G.L., Giovannini, M.G. The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus. PLoS One 2012; 7(-9-):U1222-U1240. >>> Endotoxin, LPS; CSF/CNS (fourth ventricle); Rat; Control animals received mp w/ aCSF; animal info (Wistar, male, 22 mo old); post op. care (bupivicaine on scalp for pain, sterile isotonic saline SC for dehydration); aCSF recipe.

11944 Soliman, M.L., Smith, M.D., Houdek, H.M., Rosenberger, T.A. Acetate supplementation modulates brain histone acetylation and decreases interleukin-1-beta expression in a rat model of neuroinflammation. Journal of Neuroinflammation 2012; 9(-;-):U1-U14. >>> Endotoxin, LPS; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ artificial CSF; animal info (Sprague Dawley, male, 200-250 g); Plastics One cannula used.

11929 Belarbi, K., Jopson, T., Tweedie, D., Arellano, C., Luo, W.M., Greig, N.H., Rosi, S. TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. Journal of Neuroinflammation 2012; 9(-;-):U1-U13. >>> Endotoxin, E. Coli; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Animal info (3 mo old, male, F344).

11792 Sun, Y., Todd, B.J., Thornton, K., Etgen, A.M., Neal-Perry, G. Differential Effects of Hypothalamic IGF-I on Gonadotropin Releasing Hormone Neuronal Activation During Steroid-Induced LH Surges in Young and Middle-Aged Female Rats. Endocrinology 2011; 152(-11-):4276-4287. >>> JB-1; insulin-like growth factor-1; CSF, artificial; CSF/CNS (third ventricle); Rat; 2002; animal info (young , 3-4 mo old, middle-aged, retired breeders, 9-11 mo old, female Sprague Dawley, ovariohysterectomized); guide cannula used; cannula placement verified by tracking the cannula path in brain sections; artificial CSF recipe; peptides;.

11733 Belarbi, K., Arellano, C., Ferguson, R., Jopson, T., Rosi, S. Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks. BRAIN BEHAVIOR AND IMMUNITY 2012; 26(-1-):18-23. >>> Endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ vehicle; animal info (3 mo old, male, F344).

11574 Ryan, K.K., Li, B., Grayson, B.E., Matter, E.K., Woods, S.C., Seeley, R.J. A role for central nervous system PPAR-gamma in the regulation of energy balance. Nature Medicine 2011; 17(-5-):623-U145. >>> GW9662; DMSO; CSF/CNS (third ventricle); Rat; 2006; Animal info (adult, male, Long Evans, HFD); ALZET brain infusion kit used; 33% DMSO used; Plastics One cannula use.

11517 Mul, J.D., la Fleur, S.E., Toonen, P.W., frasiab-Middelman, A., Binnekade, R., Schetters, D., Verheij, M.M.M., Sears, R.M., Homberg, J.R., Schoffelmeer, A.N.M., Adan, R.A.H., DiLeone, R.J., De Vries, T.J., Cuppen, E. Chronic Loss of Melanin-Concentrating Hormone Affects Motivational Aspects of Feeding in the Rat. PLoS One 2011; 6(-5-):U304-U316. >>> Neuropeptide-EI; CSF, artificial; CSF/CNS (third ventricle); Rat; 2002; Controls received mp w/ vehicle; animal info (pmch +/+, pmch -/-, male, Wistar); peptides; pumps replaced after 13 days; ALZET brain infusion kit 1 used.

11136 Tong, J., Mannea, E., Aime, P., Pfluger, P.T., Yi, C.X., Castaneda, T.R., Davis, H.W., Ren, X.Y., Pixley, S., Benoit, S., Julliard, K., Woods, S.C., Horvath, T.L., Sleeman, M.M., D'Alessio, D., Obici, S., Frank, R., Tschoep, M.H. Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans. Journal of Neuroscience 2011; 31(-15-):5841-5846. >>> Ghrelin; Saline, isotonic; CSF/CNS (third ventricle); Rat; Controls received mp w/ vehicle; animal info (male, 300-350 g, Wistar, 280-350 g); peptides; behavioral testing (Sniff frequency, Conditioned odor aversion); cannula placement verified by angiotensin II dipsogenic thirst test.

11130 Reisenauer, C.J., Bhatt, D.P., Mitteness, D.J., Slanczka, E.R., Gienger, H.M., Watt, J.A., Rosenberger, T.A. Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation. Journal of Neurochemistry 2011; 117(-2-):264-274. >>> Endotoxin, LPS; CSF/CNS (fourth ventricle); Rat; 2004; Controls received mp w/ aCSF; animal info (male, Sprague-Dawley, 160-180 g); Plastics One cannula used (Model 3280PM).

10985 Basselin, M., Ramadan, E., Chen, M., Rapoport, S.I. Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites. Neurochemical Research 2011; 36(-1-):139-145. >>> Endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Fischer 344); post op. care (triple antibiotic ointment, sterile isotonic saline).

 

Since 1977, scientist around the world have used ALZET pumps to conduct their research, publishing their results in high-impact journals. The ALZET bibliography now contains over 16,000 publications! We can perform a custom search for references relevant to your research.

Request your ALZET bibliography search!

 

Order the ALZET SurgicalImplantation Video

What researchers are saying...

“Pump implantation and subsequent infusion of either A-CSF or PAI-1 did not impair the mice’s ability to perform a previously learned motor task.” Seeds et al., The Journal of Neuroscience 2003;23(19):7368-7375.