References on Immunology Research Using ALZET® Osmotic Pumps

16355 Guo, D., Li, K., Yang, M., Zhang, H., Miao, Y. Levobupivacaine attenuates lipopolysaccharide-induced acute lung injury. Fundam Clin Pharmacol 2016; 30(-4-):307-15. >>> Levobupivacaine; Saline; SC; Rat; Controls received mp w/ vehicle; animal info (adult male Sprague Dawley rats, 250-300 g); functionality of mp verified by plasma levels; dose-response (pg. 308, 312); immunology; Dose (0.5 mg/kg/hr, 1.0 mg/kg/hr, 1.5 mg/kg/hr); Resultant plasma level (pg. 312);.

16328 Dong, Y., Liu, H., Zhang, X., Xu, F., Qin, L., Cheng, P., Huang, H., Guo, F., Yang, Q., Chen, A. Inhibition of SDF-1alpha/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis. Int J Mol Sci 2016; 17(-6-):. >>> AMD3100; PBS; SC; Mice; 1004; Controls received mp w/ vehicle and sham operation; animal info (C57BL/6J mice (30 males, 2 months old)); immunology; (AMD3100 is an immunostimulant); inhibitor of CXCR4; transected the anterior cruciate ligament on the right knee; caused joint instability; Dose (180 ug/day);.

16294 Caviness, K., Bughio, F., Crawford, L. B., Streblow, D. N., Nelson, J. A., Caposio, P., Goodrum, F. Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency. MBio 2016; 7(-2-):e01986. >>> Colony-stimulating factor, G; AMD3100; IP; Mice (NOD/SCID); 1007D; animal info (NOD-scid humanized (huNSG) mice); gene therapy; immunology; Engraftment of human CD45+ cells; viral persistence; Dose (300mg/ml Colony-stim; 125 ug AMD3100);.

16277 Yin, Y., Li, Z., Gao, L., Li, Y., Zhao, J., Zhang, W. AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1. Mol Cell Endocrinol 2015; 417(--):20-6. >>> Nesfatin-1; SC; mice; 1002; Controls received mp w/ vehicle; animal info (C57BL/6J mice); animal info (C57BL/6J mice); immunology;“Such an approach has been demonstrated to significantlyimprove glucose tolerance in the manner independent of food intake in mice fed either standard chow or high fat diet” pg 22; Pumps primed in 37 Degrees C for 4 hours; Dose (2.5 pmol/mouse/hr);.

16239 Schneider, J. S., Seyfried, T. N., Choi, H. S., Kidd, S. K. Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease. PLoS One 2015; 10(-12-):e0143351. >>> Sialidase, vibrio cholera; CSF, artificial; CSF/CNS; mice; 2004; Controls received mp w/ vehicle; animal info (Male C57Bl6 mice, 7–10 weeks); ALZET brain infusion kit 3 used; good methods (pg. 3); post op. care (buprenorphine); immunology; brain tissue distribution; VCS aka Vibrio cholera sialidase; (aCSF recipe: 150mMNa, 3mMK, 1.4mMCa, 0.8mMMg, 1mMP and 155mMCl); anesthetized with ketamine/xylazine; Dose (0.25, 0.50, or 1.0U/mL); Brain coordinates; -0.22mm from Bregma, 0.87mm lateral to the midline, and 2.5mmbelow the cortical surface.

16233 Rabinovich-Toidman, P., Rabinovich-Nikitin, I., Ezra, A., Barbiro, B., Fogel, H., Slutsky, I., Solomon, B. Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS. PLoS One 2015; 10(-11-):e0143420. >>> Antibody, monoclonal, BBS; CSF/CNS (right lateral ventricle); mice; 2006; Controls received mp w/ isotype-matched non relevant MAb; animal info (male Hemizygous B6SJLTgN (SOD1G93A) 1 Gur mice); brain infusion cannula used; neurodegenerative (ALS); immunology; antibodies infused; MAb aka Monoclonal antibody; Ketamine and Xylazine anesthesia; Dose (1.5 mg/mL); Brain coordinates; l-2mm [Bregma] in the anterio-posterior direction, 2.8mm in mediolateral direction and 3mm depth.

16254 Yongzhi Li,, Keiko Tanaka,, Li Wang,, Yasuhito Ishigaki, Nobuo Kato4  Journal of Experimental Medicine 2015; 237(--):329-338. >>> NMDAR-CSF; saline; CSF/CNS (left lateral ventricle); mice; 1004; Controls received mp w/ vehicle; animal info: C57BL/6 male mice (age: 8 weeks; weight: 22-24 g); functionality of mp verified by behavioral tests; neurodegenerative (anti-NMDAR encephalitis); behavioral testing (spontaneous locomotor activity, open field test, NOR test, Morris Water maze); Immunology, immunotherapy; brain tissue distribution; cyanoacrylate adhesive;“The diffusion of methlene blue in all ventricles was confirmed in all mice examined” pg 331; Cannula placement verified via methylene blue or thionine solution injection into brain; NMDAR-CSF aka Anti-N-methyl-D-aspartate receptor-CSF; CSF collected from patients with anti-NMDAR encephalitis; Brain coordinates; 0.4 mm posterior to bregma, 1.0 mm lateral to the lambda point, and 2.0 mm deep from the dural surface.

16198 Li, J. Y., D'Amelio, P., Robinson, J., Walker, L. D., Vaccaro, C., Luo, T., Tyagi, A. M., Yu, M., Reott, M., Sassi, F., Buondonno, I., Adams, J., Weitzmann, M. N., Isaia, G. C., Pacifici, R. IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice. Cell Metab 2015; 22(-5-):799-810. >>> Parathyroid hormone, human (1-34); SC; mice; 1002; Controls received mp w/ vehicle; animal info: 16-week-old female mice, C57BL/6 WT; functionality of mp verified by flow cytometry; dose-response (pg 808); replacement therapy (human parathyroid hormone); immunology; peptides; Dose: 80 mg/kg/day.

16192 Kim, J., Yoon, H., Horie, T., Burchett, J. M., Restivo, J. L., Rotllan, N., Ramirez, C. M., Verghese, P. B., Ihara, M., Hoe, H. S., Esau, C., Fernandez-Hernando, C., Holtzman, D. M., Cirrito, J. R., Ono, K., Kim, J. microRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain. J Neurosci 2015; 35(-44-):14717-26. >>> anti-miR-33; CSF/CNS (intracerevrovenctricular); Mice; Controls received negative control; animal info: mir-33 knock-out mice, two month-old APPsw/PSEN1_9 (APP/PS1) transgenic mice; neurodegenerative (Alzheimer’s); immunology; brain tissue distribution; Dose: 30 ug/d.

16166 Rhee, Y. H., Yi, S. H., Kim, J. Y., Chang, M. Y., Jo, A. Y., Kim, J., Park, C. H., Cho, J. Y., Choi, Y. J., Sun, W., Lee, S. H. Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. Sci Rep 2016; 6(--):32025. >>> Raf-Transducer cells, conditioned media; leukemia inhibitory factor; fibroblast growth factor 2; vascular endothelial growth factor; CSF, artificial; CSF/CNS; Mice; 1007D; Controls received mp w/ vehicle or control media; animal info (male, C57Bl6, 50-100g); ALZET brain infusion kit 2 used; immunology; cyanoacrylate adhesive; Brain coordinates;.

16159 Qiu, Y., Tao, L., Zheng, S., Lin, R., Fu, X., Chen, Z., Lei, C., Wang, J., Li, H., Li, Q., Lei, B. AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-kappaB and STAT3 Pathways. Sci Rep 2016; 6(--):31912. >>> A-779; Water, sterile; SC; Mice; Controls received mp w/ vehicle; animal info (6-8 weeks old); immunology; peptides; Dose (125 ug/kg/h);.

16155 Pini, A., Boccalini, G., Lucarini, L., Catarinicchia, S., Guasti, D., Masini, E., Bani, D., Nistri, S. Protection from Cigarette Smoke-Induced Lung Dysfunction and Damage by H2 Relaxin (Serelaxin). J Pharmacol Exp Ther 2016; 357(-3-):451-8. >>> Serelaxin; SC; Guinea pig; Controls received mp w/ vehicle; animal info (male, Hartley albino, 300-350g); immunology; immunology; Dose (1 or 10 ug/day);.

16150 Pang, Y., Li, Y., Lv, Y., Sun, L., Zhang, S., Li, Y., Wang, Y., Liu, G., Xu, M. J., Wang, X., Jiang, C. Intermedin Restores Hyperhomocysteinemia-induced Macrophage Polarization and Improves Insulin Resistance in Mice. J Biol Chem 2016; 291(-23-):12336-45. >>> Intermedin; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J, 6 weeks old); immunology; peptides; diabetes; Dose (318 ng/kg/h);.

16146 Okizaki, S., Ito, Y., Hosono, K., Oba, K., Ohkubo, H., Kojo, K., Nishizawa, N., Shibuya, M., Shichiri, M., Majima, M. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1beta by Recruited Macrophages. Am J Pathol 2016; 186(-6-):1481-98. >>> Placenta growth factor, recombinant human; antibody, interleukin-1B; PBS; SC; Mice; 1007D; Controls received mp w/ vehicle or control antibody; animal info (male, C57BL6, 8 weeks old, STZ); immunology; diabetes; Dose (PlGF 10 ug/mouse; anti-IL-1B 1 ug/day);.

16145 Nojiri, T., Hosoda, H., Zenitani, M., Tokudome, T., Kimura, T., Miura, K., Miyazato, M., Okumura, M., Kangawa, K. Atrial natriuretic peptide protects against cisplatin-induced granulocytopenia. Cancer Chemother Pharmacol 2016; 78(-1-):191-7. >>> Atrial natriuretic peptide; Saline; SC; Mice; 1003D; Controls received mp w/ vehicle; animal info (C57BL6, 7 weeks old); toxicology; immunology; Dose (1.5 ug/kg/min);.

16088 Zhou, C., Huang, J., Chen, J., Lai, J., Zhu, F., Xu, X., Wang, D. W. CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response. Cell Physiol Biochem 2016; 39(-2-):721-39. >>> Angiotensin II; SC; Mice; 1002; animal info (male, C57BL6J, 8 weeks old); cardiovascular; immunology; peptides; bp measured using tail-cuff; Dose (800 ug/kg/day);.

16077 Zendedel, A., Johann, S., Mehrabi, S., Joghataei, M. T., Hassanzadeh, G., Kipp, M., Beyer, C. Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. Mol Neurobiol 2016; 53(-5-):3063-75. >>> Stromal cell-derived factor-1, alpha; PBS; BSA; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 14 weeks old, 350-400g); 1% BSA used; post op. care (saline rehydration; baytril 0.3 ml SC BID; manual bladder emptying BID); behavioral testing (BBB locomotor test); immunology;.

16042 Thirunavukkarasu, S., Khan, N. S., Song, C. Y., Ghafoor, H. U., Brand, D. D., Gonzalez, F. J., Malik, K. U. Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice. Am J Pathol 2016; 186(-8-):2204-19. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, ApoE Cyp1b1, 16 weeks old, 28-32g); cardiovascular; immunology; peptides; Dose (700 ng/kg/min);.

15998 Honjo, T., Chyu, K. Y., Dimayuga, P. C., Lio, W. M., Yano, J., Trinidad, P., Zhao, X., Zhou, J., Cercek, B., Shah, P. K. Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice. PLoS One 2015; 10(-6-):e0131731. >>> Angiotensin II; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, apoE -/-, 10 weeks old); post op. care (SC analgesic); cardiovascular; immunology; peptides; Dose (1000 ng/kg/min);.

15969 Liang, W., Lindeman, J. H., Menke, A. L., Koonen, D. P., Morrison, M., Havekes, L. M., van den Hoek, A. M., Kleemann, R. Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1beta-induced chronic inflammation. Lab Invest 2014; 94(-5-):491-502. >>> LPS; interluekin-1, beta; PBS; SC; mice; 1004; Controls received mp w/ vehicle; treated with either HFD + PBS (minipump) or HFD only; animal info (Male APOE3L.CETP mice were 10–14 weeks old); functionality of mp verified by plasma level; immunology; inflammatory response; LPS aka lipopolysaccharide; IL-1B aka interleuking-1B; HFD aka high fat diet; Dose: LPS, 5 ug/day; IL-1B, 100 ng/day; Resultant plasma level (pg. 493, 499); Industry authored (Journal of Laboratory Investigation);.

15958 Li, F., Downing, B. D., Smiley, L. C., Mund, J. A., Distasi, M. R., Bessler, W. K., Sarchet, K. N., Hinds, D. M., Kamendulis, L. M., Hingtgen, C. M., Case, J., Clapp, D. W., Conway, S. J., Stansfield, B. K., Ingram, D. A., Jr. Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo. Circulation 2014; 129(-11-):1213-24. >>> Angiotensin II; Saline; SC; Mice (transgenic); 2006; Controls received mp w/ vehicle; animal info (male, Nf1fl+/- or WT, 12 weeks old); no stress (see pg. 1214); cardiovascular; immunology; peptides; Interesting (first animal model of NF1 aneurysm disease);.

15907 Gallego-Delgado, J., Baravian, C., Edagha, I., Ty, M. C., Ruiz-Ortega, M., Xu, W., Rodriguez, A. Angiotensin II Moderately Decreases Plasmodium Infection and Experimental Cerebral Malaria in Mice. PLoS One 2015; 10(-9-):e0138191. >>> Angiotensin II; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; Controls received mp w/ vehicle; cardiovascular; immunology;"Since Ang II is rapidly degraded in plasma, to experimentally modify the levels of Ang II in mice, it is required to implant intra-dermal micro-pumps that provide a constant delivery of Ang II into the blood"pg 5; Dose (100 or 500 ng/kg/min);.

15891 Tsutsumi, Toshihiko, Yamakawa, Syougo, Ishihara, Akira, Yamamoto, Aimi, Tanaka, Tamotsu, Tokumura, Akira  Toxicology Reports 2015; 2(--):121-129. >>> Aristolochic acid; SC; Rat; Controls received mp w/ vehicle; animal info (male, Wister/ST, 4-5 weeks old); immunology;.

15889 Tajiri, K., Sakai, S., Kimura, T., Machino-Ohtsuka, T., Murakoshi, N., Xu, D., Wang, Z., Sato, A., Miyauchi, T., Aonuma, K. Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice. Life Sci 2014; 118(-2-):288-96. >>> SB209670; Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, BALB/c, 6-8 weeks old); cardiovascular; immunology; Dose (10 mg/kg/day);.

15882 Rai, P., Lederman, R., Haque, S., Rehman, S., Kumar, V., Sataranatrajan, K., Malhotra, A., Kasinath, B. S., Singhal, P. C. Renin angiotensin system modulates mTOR pathway through AT2R in HIVAN. Exp Mol Pathol 2014; 96(-3-):431-7. >>> Telmisartan; PD123319; Doxycycline; aliskiren; Saline; water; SC; mice; 2004; Controls received mp w/ vehicle; animal info : Tg26 mice; FVBN mice, Tg26 mice; Vpr transgenic mice (4 week old); immunology; Dose: Telmisartan (AT1R blocker, 300Ǩg/day), PD123319 (AT2R blocker, 3Ǩg/day); Doxycycline + aliskiren (50 mg/kg).

15860 Xiyan Zhang, MD,, Fanqing Meng, MD,, Jie Song, MD,, Li Zhang, MD, PhD,, Jiali Wang, MD,, Dongliang Li, MD, PhD,, Liang Li, MD,, Ping Dong, MD,, Bo Yang, MD,, Yuguo Chen, MD, PhD  J Cardiovasc. Pharmacol 2016; 67(-1-):76-85. >>> Angiotensin II; SC; Rat; 2002; animal info (male, Sprague Dawley, 250-300g); animal info (male, Sprague Dawley, 250-300g); immunology; peptides; bp measured using tail cuff; Dose (200 ng/kg/min);.

15846 DONGYING XUAN,, QIANQIAN HAN,, QISHENG TU, LAN ZHANG,, LIMING YU, DANA MURRY,, TIANCHI TU,, YIN TANG,, JANE B. LIAN,, GARY S. STEIN,, PALOMA VALVERDE,, JINCAI ZHANG,, JAKE CHEN  Journal of Cellular Physiology 2016; 23(-1-):1090-1096. >>> Adiponectin; SC; Mice; 1004; Controls received no mp; animal info (male, APN -/- or WT, 12 weeks old); immunology; Dose (2.5 ug/day);.

15839 Christine Weber, Stephanie B. Telerman, Andreas S. Reimer, Ines Sequeira, Kifayathullah Liakath-Ali, Esther N. Arwert, Fiona M.Watt  Cancer Res 2016; 76(-4-):805-817. >>> arginine, N(omega)-hydroxy-nor-l; SC; Mice; 1004; animal info (InvEE); functionality of mp verified by plasma levels; stress/adverse reaction: (see pg. 811); stability verified by (10 days see pg 811); immunology;“Continuous dosing at a rate of 0.25 mL per hour ensured constant compound levels. Successful ARG1 inhibition was confirmed in blood plasma and wounded skin samples taken 5 days after implantation” pg 811; nor-NOHA aka N(omega)-hydroxy-nor-l-arginine;.

15838 Zenggeng Wang, MD, Qinghua Wu, MD, Xiangbi Nie, MD, Jinghua Guo, MD, Chunli Yang, MD  Journal of Surgical Research 2016; 200(--):283-289. >>> Esmolol; Saline; IV (jugular); Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-12 weeks old); cardiovascular; immunology; Dose (6.7 ug/kg/min);.

15834 Gisela Segond von Banchet,, Christian K€onig,, Jessica Patzer,, Annett Eitner,, Johannes Leuchtweis,, Matthias Ebbinghaus,, Michael K. Boettger,, Hans-Georg Schaible  ARTHRITIS&RHEUMATOLOGY 2016; 68(-2-):532-541. >>> Anakinra; SC; Rat; 2ML4; Controls received mp w/ saline; animal info (female, Lewis, 6-8 weeks old, 160-180g); animal info (female, Lewis, 6-8 weeks old, 160-180g); immunology; delayed delivery for 5 days; Dose (53 mg/kg/day);.

15816 Amanda K Sampson, Jennifer C Irvine, Waled A Shihata, Dragana Dragoljevic, Natalie Lumsden, Olivier Huet, Tyrone Barnes, Thomas Unger, Ulrike M Steckelings, Garry L Jennings, Robert E Widdop, Jaye P F Chin-Dusting  british J. Pharmacol 2016; 173(--):729-740. >>> Compound 21; Mice; 2004; Controls received mp w/ saline; animal info (male, ApoE -/-,k 6 weeks old); immunology; bp measured using tail cuff;.

15804 Mark K. Nøhr, Anete Dudele, Morten M. Poulsen, Lene H. Ebbesen, Yulia Radko, Lars P. Christensen, Niels Jessen, Bjørn Richelsen, Sten Lund, Steen B. Pedersen  PLoS One 2016; 11(-1-):1-15. >>> Endotoxin, LPS; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL/6N, 12 weeks old); immunology; diabetes; Dose (600 ug/kg/day);.

15797 E. Maggioli, S. McArthur, C. Mauro, J. Kieswich, D.H.M. Kusters, C.P.M. Reutelingsperger, M. Yaqoob, E. Solito  Brain Behav. Immun 2016; 51(--):212-222. >>> Estradiol; Cyclodextrin, B-; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (C57BL6 or AnxA1 -/-, 2 months old, OVX ); replacement therapy (estradiol infusion); immunology; dose: 100nM.

15791 Victor V. Lima, Saiprasad M. Zemse, Chin-Wei Chiaoc,, Gisele F. Bomfimd,, Rita C. Tostes, R. Clinton Webb, Fernanda R. Giachini  Life Sci 2016; 145(--):137-143. >>> Angiotensin II; interleukin-10, recombinant mouse;; Saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, IL-10 -/- or WT, 10-12 weeks old); functionality of mp verified by plasma levels; immunology; bp measured using catheter; Dose (Ang II 90 ng/min; IL-10 0.5 ng/min);.

15790 Rui Lia, Yi Zhang, Mohamed Abdulkadir Mohameda, Xiang Weia, Cai Chenga  The International Journal of Biochemistry and Cell Biology 2016; 71(--):55-61. >>> AMD3100; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (male, A/HE, 12 weeks old); cancer (lung); immunology;.

15787 Yun-Hee Lee, Sang-Nam Kim, Hyun-Jung Kwon, Krishna Rao Maddipati, James G. Granneman  Am J Physiol Regul Integr Comp Physiol 2016; 310(--):R55-R65. >>> CL316,243; Mice; 1007D; Controls received mp w/ vehicle; animal info (mail, C57BL/6, 5-6 weeks old); immunology; Dose (0.75 nmol/hr);.

15784 Woo-Young Kwon, Hye-Na Cha, Jung-Yoon Heo, Jung-Hyun Choi, Byung Ik Jang, In-Kye Lee, So-Young Park  Life Sci 2016; 146(--):214-221. >>> Angiotensin II; SC; Mice; animal info (male, IL-10 KO, 8 weeks old; cardiovascular; immunology; peptides; Dose (1.1 mg/kg/day).

15783 S M Krishnan, J K Dowling, Y H Ling, H Diep, C T Chan, D Ferens, M M Kett, A Pinar, C S Samuel, A Vinh, T V Arumugam, T D Hewitson, B K Kemp-Harper, A A B Robertson, M A Cooper, E Latz, A Mansell, C G Sobey, G R Drummond  British J. Pharmacol 2016; 173(--):752-765. >>> Angiotensin II; MCC950; Angiotensin II; MCC950; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, WT or ASC -/-, 10-12 weeks, 25-30g); cardiovascular; immunology; peptides; enzyme inhibitor (NLRP3 inflammasome; MCC950 is a novel diarylsulfonylurea-based compound; bp measured using tail cuff; Dose (0.7 mg/kg/day);.

15778 Ai Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Takuji Kawamura, Noriyuki Kashiyama, Emiko Ito, Tadashi Watabe, Shigeo Masuda, Koichi Toda, Jun Hatazawa, Eiichi Morii, Yoshiki Sawa  SCIENTIFIC REPORTS 2016; 6(--):1-13. >>> Tacrolimus; SC; Mice; 1002; cancer (teratocarcinoma); immunology; animal info (BALB/c); functionality of mp verified by plasma levels; pumps replaced after 14 days; BLI; Dose (1.5 mg/kg);.

15765 Nardhy Gomez-Lopez, David M Olson, Sarah A Robertson  immunology and Cell Biology 2016; 94(--):79-89. >>> Interleukin-6, recombinant human;; PBS; BSA; SC; Mice (pregnant); 1007D; Controls received mp w/ vehicle; animal info (female, pregnant, Il6 +/+ or Il6 -/-, 11.5 dpc, 8-12 weeks old); 0.1% BSA used; immunology; Dose (5 ng/h);.

15754 Stephanie Dal,, Nathalie Jeandidier,, Elodie Seyfritz,, William Bietiger,, Claude Pe´ronet,, Franc¸ois Moreau,, Michel Pinget,, Elisa Maillard, and Se´verine Sigrist  EXPERIMENTAL BIOLOGY AND MEDICINE 2016; 241(--):184-192. >>> Insulin; SC; Rats; 2006; animal info (male, Wistar, 180-200g, STZ); immunology; diabetes;"The intensive subcutaneous insulin administrationperformed using a mini pump in our study led to animprovement in the metabolic control of diabetic rats, as confirmed by a decrease in fructosamine levels and an increase in body weight after four weeks of treatment. Moreover, blood insulin concentration was maintained at the same level throughout the study attesting to the efficiency of this therapy."pg 189; Dose (2 UI/200g/day);.

15742 Chih-Zen Chang, MD, Shu-Chuan Wu, Ms, and Aij-Lie Kwan, MD, PhD  Journal of Surgical Research 2015; (-199-):676-687. >>> Mercaptopurine, 6-; Saline; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 320-420g); immunology; Dose (0.5/1/2 mg/kg/day);.

15730 Sun-Young Ahna,, Sung-Hwa Sohna,, Sang-Yeon Lee,, Hye-Lim Park,, Yong-Wook Park,, Hun Kim,, Jae-Hwan Nam  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2016; (-40-):924-930. >>> Endotoxin, LPS; Tween 80; saline; water; SC; mice; 1004; Controls received mp w/ vehicle; animal info: 12-wk old, male mice (C57BL/6); %0.1of Tween 80; dose-response (charts and images, pages 927, 928); immunology; response to influenza virus after introduction to LPS;“They produce a constant flowrate over a period from 1 day to 6 weeks using the principle of osmotic pressure difference between components of the device.The advantage of this type of pump is that it can continuously infuse the target reagent.” pg 925; Dose: 300 ug/kg/day.

15720 Shameena Bake,, Andre K. Okoreeh,, Robert C. Alaniz,, and Farida Sohrabji  Endocrinology 2016; (-157-):61-69. >>> Insulin-like growth factor-I, human recombinant; CSF, artificial; SC; Rat; 1003D; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 9-11 months old); animal info (female, Sprague Dawley, 9-11 months old); animal info (female, Sprague Dawley, 9-11 months old); immunology; cyanoacrylate adhesive; pumps primed overnight;.

15239 Wolfs, T.G.A.M., Kramer, B.W., Thuijls, G., Kemp, M.W., Saito, M., Willems, M.G.M., Senthamarai-Kannan, P., Newnham, J.P., Jobe, A.H., Kallapur, S.G. Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2014; 306(-5-):G382-G393. >>> Endotoxin, LPS; Intra-amniotic; Sheep (fetus); Controls received mp w/ saline; animal info (124 gestation day); immunology;.

15245 Wei, Z.H., Spizzo, I., Diep, H., Drummond, G.R., Widdop, R.E., Vinh, A., Vinh, A. Differential Phenotypes of Tissue-Infiltrating T Cells during Angiotensin II-Induced Hypertension in Mice. PLoS One 2014; 9(--):U1178-U1198. >>> Angiotensin II; NaCl; acetic acid; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6J, 10-12 weeks old); cardiovascular; immunology; peptides; bp measured using tail cuff;.

15238 Wallace, K., Morris, R., Kyle, P.B., Cornelius, D., Darby, M., Scott, J., Moseley, J., Chatman, K., LaMarca, B. Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome. HYPERTENSION IN PREGNANCY 2014; 33(-1-):41-54. >>> Sflt-1; sEndoglin; IP; Rat (pregnant); 1002; Animal info (female, Sprague Dawley, 220-250g, pregnant, GD 12); no stress (see pg.4); immunology;.

15233 Sharp, K.G., Yee, K.M., Stiles, T.L., Aguilar, R.M., Steward, O. A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury. EXPERIMENTAL NEUROLOGY 2013; 248(-;-):321-337. >>> Ibuprofen; Saline; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 9-10 weeks old); spinal cord injury; post op. care (bladders expressed BID); behavioral testing (hindlimb locomotor function; gridwalk task, footprint analysis, girdle test, plantar von frey); immunology; pumps primed primed for 16h in 37C saline;.

15225 Ojima, A., Oda, E., Higashimoto, Y., Matsui, T., Yamagishi, S. DNA aptamer raised against advanced glycation end products inhibits neointimal hyperplasia in balloon-injured rat carotid arteries. INTERNATIONAL JOURNAL OF CARDIOLOGY 2014; 171(-3-):443-446. >>> AGE-aptamer; IP; Rat; 1004; Controls received mp w/ control aptamer; animal info (male, Wistar, 400g, 11 weeks old); cardiovascular; immunology;.

15217 Jin, C.Q., Jia, Y.X., Jin, C.Y., Dong, H.X., Cheng, P.P., Zhou, J.W., Wang, Y., Zheng, B.Y., Liu, F. Therapeutic effect of Halofuginone on ITP mice by regulating the differentiation of Th cell subsets. INTERNATIONAL IMMUNOPHARMACOLOGY 2014; 18(-2-):213-216. >>> MWReg30; Albumin, human serum; IP; Mice; Animal info (BALB/c, 3 monght old, 22+/-4g); cardiovascular; immunology; MWReg30 is anti-mouse CD41;.

15215 Hawryluk, G.W.J., Spano, S., Chew, D., Wang, S., Erwin, M., Chamankhah, M., Forgione, N., Fehlings, M.G. An Examination of the Mechanisms by Which Neural Precursors Augment Recovery Following Spinal Cord Injury: A Key Role for Remyelination. CELL TRANSPLANTATION 2014; 23(-3-):365-380. >>> Epithelial growth factor; fibroblast growth factor; platelet-derived growth factor; CSF/CNS (intrathecal); Rat; 1007D; Animal info (female, Wistar, 10-12 weeks old); spinal cord injury; post op. care (bladders manually evacuated TID, Minocycline 50 mg/kg 10 days, cyclosporine 10 mg/kg); behavioral testing (open field test); immunology;.

15213 Hamdi, H., Planat-Benard, V., Bel, A., Neamatalla, H., Saccenti, L., Calderon, D., Bellamy, V., Bon, M., Perrier, M.C., Mandet, C., Bruneval, P., Casteilla, L., Hagege, A.A., Puceat, M., Agbulut, O., Menasche, P. Long-Term Functional Benefits of Epicardial Patches as Cell Carriers. CELL TRANSPLANTATION 2014; 23(-1-):87-96. >>> Cyclosporine; SC; Rat; 2ML4; Animal info (female, Wistar); immunology;“Because of the planned long duration of the follow-up (6 months), concerns over daily injections of cyclosporine led us to use subcutaneously implanted microosmotic pumps preset to release the drug in a controlled fashion.” pg 93;.

15210 Drobysheva, A., Ahmad, M., White, R., Wang, H.W., Leenen, F.H.H. Cardiac sympathetic innervation and PGP9.5 expression by cardiomyocytes after myocardial infarction: effects of central MR blockade. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2013; 305(-12-):H1817-H1829. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (female, C57BL6J and B6-Ly5.1); cardiovascular; immunology; peptides;.

15193 Bakri, M., Yi, Y., Chen, L.D., Aisa, H.A., Wang, M.H., Wang, M.H. Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension540. Chinese Journal of Natural Medicines 2014; 12(--):266-272. >>> Angiotensin II; SC; Mice; Animal info (male, C57BL6J, 8 weeks old); cardiovascular; immunology; peptides;.

15187 Patel, J., McNeill, E., Douglas, G., Hale, A.B., de Bono, J., Lee, R., Iqbal, A.J., Regan-Komito, D., Stylianou, E., Greaves, D.R., Channon, K.M., Patel, J. RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nature Communications 2015; 6(--):U1-U11. >>> Angiotensin II; SC; Mice; Controls received mp w/ saline; animal info (male, ApoE -/- or Rgs1 -/-, 8-16 weeks old); cardiovascular; immunology; peptides; bp measured using tail cuff;.

15179 Zhao, J.Z., Liu, C.Q., Bai, Y.T., Wang, T.Y., Kan, H.D., Sun, Q.H., Sun, Q.H. IKK inhibition prevents PM(2.5)-exacerbated cardiac injury in mice with type 2 diabetes. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 2015; 31(--):98-103. >>> IMD-0354; DMSO; CSF/CNS; Mice; 1004; Controls received mp w/ vehicle; animal info (KKay, 7 weeks old); long-term study; cardiovascular; immunology; diabetes; used Plastics One Cannula;.

15166 Zakrzewicz, A., Atanasova, S., Padberg, W., Grau, V., Zakrzewicz, A. Monocytic Tissue Transglutaminase in a Rat Model for Reversible Acute Rejection and Chronic Renal Allograft Injury. MEDIATORS OF INFLAMMATION 2015; ;(--):U1-U13. >>> Cystamine dihydrochloride; Saline, sterile; SC; Rat; 2ML4; Controls received mp w/ vehicle; animal info (male, Lweis or F344, 270-300g); cardiovascular; immunology;.

15164 Yun, H.M., Kim, J.A., Hwang, C.J., Jin, P., Baek, M.K., Lee, J.M., Hong, J.E., Lee, S.M., Han, S.B., Oh, K.W., Choi, D.Y., Yoon, D.Y., Hong, J.T., Hong, J.T. Neuroinflammatory and Amyloidogenic Activities of IL-32beta in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2015; 52(--):341-352. >>> Amyloid protein, beta (1-42); Saline; CSF/CNS; Mice (transgenic); 2002; Controls received mp w/ control amyloid protein, beta (42-1); animal info (female, C57BL6 or IL-32B Tg, 26-30g, 16-22 weeks); ALZET brain infusion kit 1 used; neurodegenerative (Alzheimer's); immunology;.

15163 Yu, Y., Xue, B.J., Wei, S.G., Zhang, Z.H., Beltz, T.G., Guo, F., Johnson, A.K., Felder, R.B., Felder, R.B. Activation of Central PPAR-gamma Attenuates Angiotensin II-Induced Hypertension. HYPERTENSION 2015; 66(--):403-411. >>> Angiotensin II; pioglitazone, GW9662; DMSO; CSF, artificial; SC; CSF/CNS; Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); functionality of mp verified by residual volume; 20% DMSO used; Multiple pumps per animal (2); cardiovascular; immunology; peptides; Cannula placement verified via histologic analysis of cannula track; bp measured using radiotelemetry (DSI);.

15159 Yoshihara, T., Shimada, K., Fukao, K., Sai, E., Sato-Okabayashi, Y., Matsumori, R., Shiozawa, T., Alshahi, H., Miyazaki, T., Tada, N., Daida, H., Shimada, K. Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation. CIRCULATION JOURNAL 2015; 79(--):1470-U292. >>> Angiotensin II; SC; Mice; 1004; Controls received mp w/ saline; animal info (male, ApoE -/-, 12 weeks old); cardiovascular; immunology; peptides; bp measured using tail cuff;.

15156 Yassine, H., Caires, N.D., Depontieu, F., Scherpereel, A., Awad, A., Tsicopoulos, A., Leboeuf, C., Janin, A., Duez, C., Grigoriu, B., Lassalle, P., Lassalle, P. The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction. ONCOTARGET 2015; 6(--):2725-2735. >>> Endocan/S137A, recombinant human; PBS; SC; Mice (SCID); 2004; Controls received mp w/ vehicle; animal info (male, CB-17 scid/scid homozygous, 5-6 weeks old); functionality of mp verified by blood levels; cancer (colon adenocarcima HT-29); immunology;.

15154 Yang, L., Ni, L., Duan, Q.L., Wang, X.X., Chen, C., Chen, S., Chaugai, S., Zeldin, D.C., Tang, J.R., Wang, D.W., Tang, J.R. CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. PROSTAGLANDINS&OTHER LIPID MEDIATORS 2015; 116(--):64-75. >>> Isoproterenol; angiotensin II; Ascorbic acid; saline; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (male, CYP2J2 Tg or WT C57BL6); 0.002% ascorbic acid used; cardiovascular; immunology; peptides; bp measured using catheter;.

15141 Wermke, M., Camgoz, A., Paszkowski-Rogacz, M., Thieme, S., von Bonin, M., Dahl, A., Platzbecker, U., Theis, M., Ehninger, G., Brenner, S., Bornhaeuser, M., Buchholz, F., Wermke, M. RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug. BLOOD 2015; 125(--):3760-3768. >>> Fasudil; SC; Mice (NSG); Animal info (female, NSG, 4-6 weeks old); cancer (acute myeloid leukemia); immunology;.

15133 Wang, W.J., Sivakumar, W., Torres, S., Jhaveri, N., Vaikari, V.P., Gong, A., Howard, A., Golden, E.B., Louie, S.G., Schoenthal, A.H., Hofman, F.M., Chen, T.C., Chen, T.C. Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. Neurosurgical Focus 2015; 38(--):U112-U119. >>> Bevacizumab; Saline; CSF/CNS (intratumoral); Mice (nude); 1004; Controls received mp w/ vehicle; animal info (athymic, nu/nu); ALZET brain infusion kit used; cancer (glioma); immunology;"Bevacizumab was delivered into the tumor using chronic pump-mediated delivery, defined as“convection-enhanced delivery” or CED. This CED method was used because it has the advantage of achieving the desirable drug concentration in the microenvironment of the glioma while avoiding the use of high initial doses."pg 2;.

15129 Wang, J., Wang, X.F., Wei, J., Wang, M.Y., Wang, M.Y. Hyaluronan Tetrasaccharide Exerts Neuroprotective Effect and Promotes Functional Recovery After Acute Spinal Cord Injury in Rats. NEUROCHEMICAL RESEARCH 2015; 40(--):98-108. >>> Hyaluronan tetrasaccharide; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (Sprague Dawley, 12 weeks old, 250-300g); spinal cord injury; post op. care (Baytril antibacterial applied SC for 3 days); behavioral testing (locomotor activity); immunology;.

15253 Vu, B.G., Stach, C.S., Kulhankova, K., Salgado-Pabon, W., Klingelhutz, A.J., Schlievert, P.M., Schlievert, P.M. Chronic Superantigen Exposure Induces Systemic Inflammation, Elevated Bloodstream Endotoxin, and Abnormal Glucose Tolerance in Rabbits: Possible Role in Diabetes. MBIO 2015; 6(--):U999-U1008. >>> Toxic shock syndrome toxin-1; SC; Rabbit; 2006; Controls received mp w/ PBS; animal info (New Zealand White); immunology; diabetes; Toxic shock syndrome toxin-1 aka TSST-1; long-term study;.

15117 Toriyama, Y., Iesato, Y., Imai, A., Sakurai, T., Kamiyoshi, A., Ichikawa-Shindo, Y., Kawate, H., Yamauchi, A., Igarashi, K., Tanaka, M., Liu, T., Xian, X., Zhai, L.Y., Owa, S., Murata, T., Shindo, T., Shindo, T. Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases. AMERICAN JOURNAL OF PATHOLOGY 2015; 185(--):1783-1794. >>> Calcitonin gene-related peptide, alpha; calcitonin gene-related peptide (8-37), alpha; PBS; SC; Mice; Controls received mp w/ vehicle; animal info (CGRP -/-); immunology;.

15098 Tajima, S., Ikeda, Y., Enomoto, H., Imao, M., Horinouchi, Y., Izawa-Ishizawa, Y., Kihira, Y., Miyamoto, L., Ishizawa, K., Tsuchiya, K., Tamaki, T., Ikeda, Y. Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice. EUROPEAN JOURNAL OF NUTRITION 2015; 54(--):709-719. >>> Angiotensin II; SC; Mice; 1004; Animal info (male, C57BL6J, 6 weeks old); cardiovascular; immunology; peptides;.

15093 Sun, W.L., Pang, Y.L., Liu, Z.Y., Sun, L.L., Liu, B., Xu, M.J., Dong, Y.Q., Feng, J., Jiang, C.T., Kong, W., Wang, X., Kong, W. Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015; 81(--):96-106. >>> Angiotensin II; SC; Mice; 2004; Controls received mp w/ saline; animal info (ApoE -/-); cardiovascular; immunology; peptides;.

15092 Su, J., Yin, J., Qin, W., Sha, S.X., Xu, J., Jiang, C.B., Yin, J. Role for Pro-inflammatory Cytokines in Regulating Expression of GABA Transporter Type 1 and 3 in Specific Brain Regions of Kainic Acid-Induced Status Epilepticus. NEUROCHEMICAL RESEARCH 2015; 40(--):621-627. >>> Interleukin-1, receptor antagonist; tocilizumab; etanercept; CSF, artificial; Rat; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); ALZET brain infusion kit used; behavioral testing (seizure behaviors); immunology; used polycarbonate tubing;.

15072 Schneider, U., Davids, A.M., Brandenburg, S., Mueller, A., Elke, A., Magrini, S., Atangana, E., Turkowski, K., Finger, T., Gutenberg, A., Gehlhaar, C., Brueck, W., Heppner, F., Vajkoczy, P., Vajkoczy, P. Microglia inflict delayed brain injury after subarachnoid hemorrhage. ACTA NEUROPATHOLOGICA 2015; 130(--):215-231. >>> Ganciclovir; CSF/CNS; Mice; Animal info (CD11b-HSVTK, 14-14 weeks old, 22-25g); ALZET brain infusion kit used; immunology; noted 230 ul reservoir;.

15067 Saiman, Y., Jiao, J.J., Fiel, M.I., Friedman, S.L., Aloman, C., Bansal, M.B., Bansal, M.B. Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury. HEPATOLOGY RESEARCH 2015; 45(--):794-803. >>> AMD3100; PBS; SC; Mice; 1004; Controls received mp w/ vehicle; animal info (male, C57BL8); cardiovascular; immunology;“As AMD3100 has a very short half-life, we used subcutaneous osmotic pumps to allow for continual infusion of AMD3100.” pg 800;.

15066 Prasad, S., Gaedicke, S., Machein, M., Mittler, G., Braun, F., Hettich, M., Firat, E., Klingner, K., Schueler, J., Wider, D., Waesch, R.M., Herold-Mende, C., Elsaesser-Beile, U., Niedermann, G., Niedermann, G. Effective Eradication of Glioblastoma Stem Cells by Local Application of an AC133/CD133-Specific T-cell-Engaging Antibody and CD8 T Cells. CANCER RESEARCH 2015; 75(--):2166-2176. >>> Antibody, AC133xCD3 bispecific; PBS; CSF/CNS; Mice (nude); 1007D; Controls received mp w/ control antibody; animal info (NMR I nude, 6-8 weeks old); ALZET brain infusion kit 3 used; cancer (glioblastoma multiforme); immunology; cyanoacrylate adhesive;.

15060 Pitt, L.A., Tikhonova, A.N., Hu, H., Trimarchi, T., King, B., Gong, Y.X., Sanchez-Martin, M., Tsirigos, A., Littman, D.R., Ferrando, A.A., Morrison, S.J., Fooksman, D.R., Aifantis, I., Schwab, S.R., Aifantis, I. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. CANCER CELL 2015; 27(--):755-768. >>> AMD3465; PBS; SC; Mice (NOD/SCID); 2002; Controls received mp w/ vehicle; animal info (female, C57BL6, 6-8 weeks old); cancer (leukemia); immunology;.

15057 Persson, P., Friederich-Persson, M., Fasching, A., Hansell, P., Inagi, R., Palm, F., Persson, P. Adenosine A(2)a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress. Acta Physiologica 2015; 214(--):311-318. >>> CGS21680; DMSO; Ringer's solution; SC; Rat; 2004; Animal info (male, Sprague Dawley, 250-g, STZ); post op. care (carpofen 5 mg/kg SC); cardiovascular; immunology; antihypertensive; diabetes; CGS21680 is an A2aAR agonist;.

15056 Pereira, L., Medina, R., Baena, M., Planas, A.M., Pozas, E., Pozas, E. IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche. Frontiers in Cellular Neuroscience 2015; 9(--):U1-U10. >>> Interferon, gamma; Saline; CSF/CNS (third ventricle); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, STAT2 KO or 129S6/SvEv); immunology;.

15055 Nojiri, T., Hosoda, H., Tokudome, T., Miura, K., Ishikane, S., Otani, K., Kishimoto, I., Shintani, Y., Inoue, M., Kimura, T., Sawabata, N., Minami, M., Nakagiri, T., Funaki, S., Takeuchi, Y., Maeda, H., Kidoya, H., Kiyonari, H., Shioi, G., Arai, Y., Hasegawa, T., Takakura, N., Hori, M., Ohno, Y., Miyazato, M., Mochizuki, N., Okumura, M., Kangawa, K., Kangawa, K. Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):4086-4091. >>> Atrial natriuretic peptide; Saline; IV (jugular); Mice (nude); 1002; 2004; Controls received mp w/ vehicle; animal info (BALB/c nu/nu, 6 weeks old); cancer (lung); cardiovascular; immunology; used mouse jugular catheter (#7702); bp measured using tail cuff;.

15053 Nieto, F.R., Clark, A.K., Grist, J., Chapman, V., Malcangio, M., Malcangio, M. Calcitonin Gene-Related Peptide-Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen-Induced Arthritis. ARTHRITIS&RHEUMATOLOGY 2015; 67(--):1668-1677. >>> Calcitonin gene-related peptide (8-37); CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (female, Lewis, 180-200g); behavioral testing (Von Frey filaments; Plantar test); immunology; peptides;.

15110 Napier, R.J., Norris, B.A., Swimm, A., Giver, C.R., Harris, W.A.C., Laval, J., Napier, B.A., Patel, G., Crump, R., Peng, Z.H., Bornmann, W., Pulendran, B., Buller, R.M., Weiss, D.S., Tirouvanziam, R., Waller, E.K., Kalman, D., Napier, R.J. Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity. PLoS Pathogens 2015; 11(--):U1651-U1677. >>> Imatinib mesylate; Water; SC; Mice; 1007D; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6, 6 weeks old); functionality of mp verified by serum levels; dose-response (pg.9); immunology;.

15049 Na, Y.R., Yoon, Y.N., Son, D., Jung, D., Gu, G.J., Seok, S.H., Seok, S.H. Consistent Inhibition of Cyclooxygenase Drives Macrophages towards the Inflammatory Phenotype. PLoS One 2015; 10(--):U1730-U1742. >>> NA-398; SC-560; indomethacin; DMSO; SC; Mice; Controls received mp w/ vehicle; animal info (female, BALB/c); immunology;.

15037 Matsuo, Y., Gleitsmann, K., Mangner, N., Werner, S., Fischer, T., Bowen, T.S., Kricke, A., Matsumoto, Y., Kurabayashi, M., Schuler, G., Linke, A., Adams, V., Adams, V. Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 2015; 6(--):62-72. >>> Angiotensin II; Saline, normal; SC; Mice; 2004; Animal info (ApoE -/-, 4 weeks old, 20g); cardiovascular; immunology; peptides;.

15029 Maneenil, G., Kemp, M.W., Kannan, P.S., Kramer, B.W., Saito, M., Newnham, J.P., Jobe, A.H., Kallapur, S.G., Kallapur, S.G. Oral, Nasal and Pharyngeal Exposure to Lipopolysaccharide Causes a Fetal Inflammatory Response in Sheep. PLoS One 2015; 10(--):U1091-U1101. >>> Endotoxin, LPS; Oral cavity; Sheep (ewe); Controls received mp w/ saline; animal info (Merino); teratology; immunology;.

15027 Magalhaes, G.S., Rodrigues-Machado, M.G., Motta-Santos, D., Silva, A.R., Caliari, M.V., Prata, L.O., Abreu, S.C., Rocco, P.R.M., Barcelos, L.S., Santos, R.A.S., Campagnole-Santos, M.J., Campagnole-Santos, M.J. Angiotensin-(1-7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation. BRITISH JOURNAL OF PHARMACOLOGY 2015; 172(--):2330-2342. >>> Angiotensin (1-7); Saline, sterile isotonic; SC; Mice; 1004; Controls received sham surgery; animal info (male, BALB/C, 6-8 weeks old, 20-25g); cardiovascular; immunology;.

15017 Ding, W., Xu, C.Y., Wang, B., Zhang, M.M., Zhang, M.M. Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. MEDICAL SCIENCE MONITOR 2015; 21(--):U1-U8. >>> Aldosterone; Ethanol; SC; Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 220-250g); 0.5% ethanol used; replacement therapy (uninephrectomy); cardiovascular; immunology;.

15005 Li, B., Zeng, M., He, W.M., Huang, X.B., Luo, L., Zhang, H.W., Deng, D.Y.B., Zeng, M. Ghrelin Protects Alveolar Macrophages Against Lipopolysaccharide-Induced Apoptosis Through Growth Hormone Secretagogue Receptor 1a-Dependent c-Jun N-Terminal Kinase and Wnt/beta-Catenin Signaling and Suppresses Lung Inflammation. ENDOCRINOLOGY 2015; 156(--):182-192. >>> Ghrelin; Saline; IV (jugular); Rat; 2001D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 6-7 weeks old, 300 +/- 20g); immunology; pumps primed for 3 hours in 37C saline;.

14994 Kimura, T., Nojiri, T., Hosoda, H., Ishikane, S., Shintani, Y., Inoue, M., Miyazato, M., Okumura, M., Kangawa, K., Kimura, T. Protective effects of C-type natriuretic peptide on cisplatin-induced nephrotoxicity in Mice. CANCER CHEMOTHERAPY AND PHARMACOLOGY 2015; 75(--):1057-1063. >>> C-type natriuretic peptide; Glucose; SC; Mice; 1003D; Controls received mp w/ vehicle; animal info (C57BL6, 6 weeks old); functionality of mp verified by plasma levels; 5% glucose used; cardiovascular; immunology; peptides;.

14971 Iyer, R.P., Patterson, N.L., Zouein, F.A., Ma, Y.G., Dive, V., Bras, L.E.D., Lindsey, M.L., Lindsey, M.L. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution. INTERNATIONAL JOURNAL OF CARDIOLOGY 2015; 185(--):198-208. >>> RXP 470.1; Saline; SC; Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6J, 3-6 months old, myocardial infarction); cardiovascular; immunology; enzyme inhibitor (matrix metalloproteinase-12);.

14969 Hu, J.Z., Zeng, L., Huang, J.H., Wang, G., Lu, H.B., Lu, H.B. miR-126 promotes angiogenesis and attenuates inflammation after contusion spinal cord injury in rats. BRAIN RESEARCH 2015; 1608(--):191-202. >>> miR-126; Saline; CSF/CNS (intrathecal); Rat; 1003D; Controls received mp w/ control agomir; animal info (male, Sprague Dawley, 180-220g); spinal cord injury; post op. care (Ringer's solution administered IP 5 ml, penicillin G 40000 U IM QD for 3 days, bladders manually expressed BID); behavioral testing (locomotor testing, open field); immunology; pumps primed overnight at 37C.

14960 Ho, Y.H., Lin, Y.T., Wu, C.W.J., Chao, Y.M., Chang, A.Y.W., Chan, J.Y.H., Chan, J.Y.H. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. JOURNAL OF BIOMEDICAL SCIENCE 2015; 22(--):U1-U14. >>> Endotoxin, LPS; NS398; tempol; Saline; DMSO; IP; CSF/CNS; Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 10 weeks old, 250-282g); ALZET brain infusion kit 2 used; 1% DMSO used; Multiple pumps per animal (2); post op. care (IM procaine penicillin 1000IU); immunology; used dental cement; NS398 is a COX-2 inhibitor and anti-inflammatory; tempol scavanges ROS;.

14962 Hecker, M., Linder, T., Ott, J., Walmrath, H.D., Lohmeyer, J., Vadasz, I., Marsh, L.M., Herold, S., Reichert, M., Buchbinder, A., Morty, R.E., Bausch, B., Fischer, T., Schulz, R., Grimminger, F., Witzenrath, M., Barnes, M., Seeger, W., Mayer, K., Mayer, K. Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial. CRITICAL CARE 2015; 19(--):U1-U13. >>> Fish oil-based lipid emulsion; Soybean oil-based lipid emulsion; IV (jugular); Mice; Controls received mp w/ saline; animal info (ChemR23 -/- or WT Sv129/S1); 10% emulsion used; immunology;.

15701 Chan, K.C., Chan, L.S., Ip, J.C.Y., Lo, C., Yip, T.T.C., Ngan, R.K.C., Wong, R.N.S., Lo, K.W., Ng, W.T., Lee, A.W.M., Tsao, G.S.W., Kahn, M., Lung, M.L., Mak, N.K., Mak, N.K. Therapeutic targeting of CBP/beta-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin. SCIENTIFIC REPORTS 2015; 5(--):U18-U29. >>> Ac-SDKP; SC; Mice; Controls received mp w/ vehicle; animal info (male, BALB/C, 12 weeks old); functionality of mp verified by plasma levels; cardiovascular; immunology;.

14982 Jiang, X., Nguyen, T.T., Tian, W., Sung, Y.K., Yuan, K., Qian, J., Rajadas, J., Sallenave, J.M., Nickel, N.P., Perez, V.D., Rabinovitch, M., Nicolls, M.R., Nicolls, M.R. Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. AMERICAN JOURNAL OF TRANSPLANTATION 2015; 15(--):1768-1781. >>> Elafin; PBS; SC; Mice; 2002; Animal info (C57BL6J or BALB/c); immunology;.

14953 Gutierrez, L.S., Ling, J., Nye, D., Papathomas, K., Dickinson, C., Gutierrez, L.S. Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model. WORLD JOURNAL OF GASTROENTEROLOGY 2015; 21(--):6157-6166. >>> ABG-898; Glucose, sterile; SC; Mice; Controls received mp w/ vehicle; animal info (WT or TSP-1 -/-); 5% glucose used; cardiovascular; immunology; peptides;.

14928 Garofalo, S., D'Alessandro, G., Chece, G., Brau, F., Maggi, L., Rosa, A., Porzia, A., Mainiero, F., Esposito, V., Lauro, C., Benigni, G., Bernardini, G., Santoni, A., Limatola, C., Limatola, C. Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice. Nature Communications 2015; 6(--):U26-U38. >>> Interleukin-15; brain-derived neurotrophic factor; PBS; CSF/CNS (striatum); Mice; 1007D; Controls received mp w/ vehicle; animal info (male, C57BL6, 3 weeks or 2 months old); ALZET brain infusion kit 3 used; cancer (glioma, U87MG human); tissue perfusion (right striatum); immunology; pumps primed in 37C saline overnight;.

14940 Gardner, J.K., Mamotte, C.D.S., Patel, P., Yeoh, T.L., Jackaman, C., Nelson, D.J., Nelson, D.J. Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function. PLoS One 2015; 10(--):U1192-U1220. >>> TOFA; DMSO; SC; Mice; 1002; Controls received mp w/ vehicle; animal info (female, C57BL6J, 6-8 weeks old); cancer (mesothelioma); immunology; TOFA aka 5-tetradecycloxy-2-furoic acid;.

14938 Gao, Z., Nissen, J.C., Legakis, L., Tsirka, S.E., Tsirka, S.E. NICOTINE MODULATES NEUROGENESIS IN THE CENTRAL CANAL DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. NEUROSCIENCE 2015; 297(--):11-21. >>> Nicotine ditartrate; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (C57BL6); functionality of mp verified by serum cotinine levels; immunology;.

14924 Dou, L., Meng, X.Y., Sui, X.F., Wang, S.Y., Shen, T., Huang, X.Q., Guo, J., Fang, W.W., Man, Y., Xi, J.Z., Li, J., Li, J. MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes. SCIENTIFIC REPORTS 2015; 5(--):U1-U11. >>> Interleukin-6; NaCl; BSA; SC; Mice; 2001; Animal info (male, C57BL6J, 12 weeks old); 0.1% BSA used; immunology;.

15698 Chang, C.Z., Wu, S.C., Lin, C.L., Kwan, A.L., Chang, C.Z. Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. Journal of Inflammation-London 2015; 12(--):U1-U11. >>> Valproic acid; PBS; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dalwey, 300-400g); dose-response (4); ischemia (cerebral); behavioral testing (modified limb-placing test); immunology;.

14892 Chu, P.Y., Walder, K., Horlock, D., Williams, D., Nelson, E., Byrne, M., Jandeleit-Dahm, K., Zimmet, P., Kaye, D.M., Kaye, D.M. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One 2015; 10(--):U1392-U1404. >>> AMD3100; AMD3465; Water; sodium bicarbonate; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6, 6 weeks old, STZ injection); cardiovascular; immunology; bp measured using tail cuff;.

14884 Cherry, J.D., Olschowka, J.A., O'Banion, M.K., O'Banion, M.K. Arginase 1+ microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation. Journal of Neuroinflammation 2015; 12(--):U14-U26. >>> Antibody, interleukin-4Ra; CSF/CNS (hippocampus); Mice; 1004; Controls received mp w/ control antibody; animal info (APPswe/SP1dE9, 7-5 months old); ALZET brain infusion kit 3 used; neurodegenerative (Alzheimer's disease); immunology; pumps primed 48 hours in 37C saline;.

14881 Chen, H., Min, X.H., Wang, Q.Y., Leung, F.W., Shi, L., Zhou, Y., Yu, T., Wang, C.M., An, G., Sha, W.H., Chen, Q.K., Chen, Q.K. Pre-activation of mesenchymal stem cells with TNF-alpha, IL-1beta and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury. SCIENTIFIC REPORTS 2015; 5(--):U20-U33. >>> Conditioned medium, mesenchymal stem cells; IP; Rat; Controls received mp w/ non-activated MSC-CM; animal info (Sprague Dawley, adult, 280-350g); post op. care (antibiotics streptomycin and penicillin); immunology;.

14873 Chang, C.Z., Wu, S.C., Kwan, A.L., Chang, C.Z. Glycyrrhizin Attenuates Proinflammatory Cytokines through a Peroxisome Proliferator-Activated Receptor-gamma-Dependent Mechanism and Experimental Vasospasm in a Rat Model. JOURNAL OF VASCULAR RESEARCH 2015; 52(--):12-21. >>> Glycyrrhizin; Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 300-400g); cardiovascular; immunology;.

14868 Cardona, M., Lopez, J.A., Serafin, A., Rongvaux, A., Inserte, J., Garcia-Dorado, D., Flavell, R., Llovera, M., Canas, X., Vazquez, J., Sanchis, D., Sanchis, D. Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. PLoS One 2015; 10(--):U1658-U1678. >>> Ac-SDKP; SC; Mice; Animal info (male, BALB/C); cardiovascular; immunology; peptides;.

14857 Buzzelli, J.N., Pavlic, D.I., Chalinor, H.V., O'Connor, L., Menheniott, T.R., Giraud, A.S., Judd, L.M., Judd, L.M. IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment. ONCOTARGET 2015; 6(--):679-695. >>> Interleukin-11, recombinant human; SC; Mice; 1007D; Controls received mp w/ saline; animal info (WT or IL-1RT1, 12-14 weeks old); immunology;.

14840 Battaglia, G., Riozzi, B., Bucci, D., Di Menna, L., Molinaro, G., Pallottino, S., Nicoletti, F., Bruno, V., Bruno, V. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 2015; 74(--):126-136. >>> LY379268; Saline; SC; Mice; 2004; Controls received mp w/ vehicle; animal info (male, C57BL6J or SOD1G93A, 8 weeks old, 20-22g); pumps replaced every 28 days; neurodegenerative (amyotrophic lateral sclerosis); behavioral testing (rotarod testing); immunology;.

14821 Alissafi, T., Hatzioannou, A., Ioannou, M., Sparwasser, T., Gruen, J.R., Gruetzkau, A., Verginis, P., Verginis, P. De Novo-Induced Self-Antigen-Specific Foxp3(+) Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes. JOURNAL OF IMMUNOLOGY 2015; 194(--):5812-5824. >>> Myelin oligodendrocyte glycoprotein (35-55); SC; Mice; 1002; Animal info (female, BALB/c or Il10 -/-, 8-10 weeks old); immunology; Myelin oligodendrocyte glycoprotein (35-55) aka MOG 35-55;.

14817 Akahori, H., Karmali, V., Polavarapu, R., Lyle, A.N., Weiss, D., Shin, E., Husain, A., Naqvi, N., Van Dam, R., Habib, A., Choi, C.U., King, A.L., Pachura, K., Taylor, W.R., Lefer, D.J., Finn, A.V., Finn, A.V. CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury. Nature Communications 2015; 6(--):U1-U14. >>> TWEAK; NBD; PBS; Mice; 2004; Controls received mp w/ vehicle or control peptide; animal info (male, CD163 -/-, 8 weeks old); ischemia (hind limb); immunology; TWEAK is a secreted pro-inflammatory cytokine of the tumor necrosis factor family; NBD is is an inhibitor of NF-kB;.

14814 Aikawa, E., Fujita, R., Kikuchi, Y., Kaneda, Y., Tamai, K., Tamai, K. Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFRalpha(+) mesenchymal cells from bone marrow. SCIENTIFIC REPORTS 2015; 5(--):U23-U35. >>> AMD3100; SC; Mice; Controls received mp w/ PBS; animal info (male, C57BL6); immunology;.

14811 Ager, E.I., Kozin, S.V., Kirkpatrick, N.D., Seano, G., Kodack, D.P., Askoxylakis, V., Huang, Y.H., Goel, S., Snuderl, M., Muzikansky, A., Finkelstein, D.M., Dransfield, D.T., Devy, L., Boucher, Y., Fukumura, D., Jain, R.K., Jain, R.K. Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy. JOURNAL OF THE NATIONAL CANCER INSTITUTE 2015; 107(--):U137-U148. >>> 1400W dihydrochloride; SC; Mice (nude); 1002; Animal info (female, nu/nu, 6-8 weeks old); cancer (breast); enzyme inhibitor (nitric oxide synthase); immunology;.

14784 Zheng, Y.N., Tang, L., Huang, W.H., Yan, R.Y., Ren, F.F., Luo, L., Zhang, L., Tang, L. Anti-Inflammatory Effects of Ang-(1-7) in Ameliorating HFD-Induced Renal Injury through LDLr-SREBP2-SCAP Pathway. PLoS One 2015; 10(--):U993-U1010. >>> Angiotensin (1-7); Saline; SC; Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6, 6 weeks old); cardiovascular; immunology; antihypertensive; peptides;.

14780 Zhu, Y., Soderblom, C., Krishnan, V., Ashbaugh, J., Bethea, J.R., Lee, J.K., Lee, J.K. Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury. NEUROBIOLOGY OF DISEASE 2015; 74(--):114-125. >>> Sunitinib malate; DMSO; CSF/CNS (intrathecal); Mice; 1002; Animal info (female, 8 weeks old); functionality of mp verified by use of evans blue dye; 2.5% DMSO used; spinal cord injury; immunology; used ALZET mouse IT catheter;.


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What researchers are saying...

“We found recently that 21 d of treatment of rats with SSRIs, at clinically relevant and stable serum concentrations (achieved by the use of osmotic minipumps), caused robust downregulation of the SERT.”... “Studies on the effects of chronic antidepressants on the SERT have resulted in inconsistent reports (Owens and Nemeroff, 1998). Among the factors that may contribute to such inconsistency is the route of drug administration. In most studies of chronic administration of Ads to rats, the drugs are given intraperitoneally or subcutaneously, either once or twice daily. As rats metabolize these drugs more rapidly than humans, such dosage schedules can result in appreciable fluctuations in the serum concentration of drug throughout the day. For certain pharmacologic effects, sustained drug action may be needed” Benmansour et al. The Journal of Neuroscience 2002; 22(15):6766-6772.