References on Cerebral Ischemia (stroke) Research Using ALZET^® Osmotic Pumps

Q0636 Tsai,S.Y., Papadopoulos,C.M., Schwab,M.E., Kartje,G.L. Delayed Anti-Nogo-A Therapy Improves Function After Chronic Stroke in Adult Rats. Stroke 2011; 42(-1-):186-190. >>> Antibody, anti-Nogo-A; CSF/CNS; Rat; 2ML2; 2 weeks; Controls received mp w/ inactive control antibody or no treatment; animal info (adult, male, Long Evans, black-hooded, 300 g); ischemia (stroke).

Q0116 Ge,Z.D., van der Hoeven,D., Maas,J.E., Wan,T.C., Auchampach,J.A. A3 adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells. Journal of Molecular and Cellular Cardiology 2010; 49(-2-):280-286. >>> Methylcarboxamide, Cl-IB-; PBS; DMSO; SC; Mice; 24 hours; Controls received mp w/ vehicle; cardiovascular; animal info (male, C57BL/6, B6-CD45 congenic, A3KO, BM chimeric, 25-30 g, coronary occlusion); ischemia (cardiac); 50% DMSO; A3 adenosine teceptor agonist; Cl-IB-MECA.

Q0017 Hotta,H., Miura,T., Miki,T., Togashi,N., Maeda,T., Kim,S.J., Tanno,M., Yano,T., Kuno,A., Itoh,T., Satoh,T., Terashima,Y., Ishikawa,S., Shimamoto,K. Angiotensin II Type 1 Receptor-Mediated Upregulation of Calcineurin Activity Underlies Impairment of Cardioprotective Signaling in Diabetic Hearts. Circulation Research 2010; 106(-1-):129-U260. >>> Valsartan; losartan; Rat; 2002; 14 days; Cardiovascular; animal info (OLETF, LETO, 25-30 weeks old); ischemia (cardiac).

Q0019 Iwata,M., Inoue,S., Kawaguchi,M., Nakamura,M., Konishi,N., Furuya,H. Posttreatment but Not Pretreatment with Selective beta-Adrenoreceptor 1 Antagonists Provides Neuroprotection in the Hippocampus in Rats Subjected to Transient Forebrain Ischemia. Anesthesia and Analgesia 2010; 110(-4-):1126-1132. >>> Propanolol; esmolol; landiolol; Saline, physiological; IV (femoral); Rat; 2ML1; 5 days; Controls received mp w/vehicle; animal info (male, Sprague-Dawley, 270-330 g, BCAO); ischemia (cerebral); behavioral testing (motor function, prehensile traction test).

Q0021 Li,B., Piao,C.S., Liu,X.Y., Guo,W.P., Xue,Y.Q., Duan,W.M., Gonzalez-Toledo,M.E., Zhao,L.R. Brain self-protection: The role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Research 2010; 1327(-;-):91-102. >>> Ara-C; Saline; CSF/CNS; Mice; rat; 1007D; 7 days; Controls received mp w/vehicle; animal info (male, C57BL, 3 months old; male, SHR, 3-5 months old; CCAO, MCAO); ischemia (cerebral).

Q0356 Menn,B., Bach,S., Blevins,T.L., Campbell,M., Meijer,L., Timsit,S. Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models. PLoS One 2010; 5(-8-):U113-U123. >>> Roscovitine, S-; DMSO; Krebs-Ringer's solution; CSF/CNS; SC; Rat; mice; 1003D; 48, 72 hours; Controls received mp w/ vehicle; animal info (P60, male, C57B/6, 20-25 g; P60, male, Sprague Dawley, 280-320 g); ischemia (cerebral).

Q0072 Murikinati,S., Juettler,E., Keinert,T., Ridder,D.A., Muhammad,S., Waibler,Z., Ledent,C., Zimmer,A., Kalinke,U., Schwaninger,M. Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. FASEB Journal 2010; 24(-3-):788-798. >>> JWH-133; PBS; BSA; DMSO; IP; Mice; 1003D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral); animal info (C57BL/6, CB1 -/-, CB2 -/-, 2-3 months old); 20% DMSO used.

Q0183 Ren,B., Deng,Y., Mukhopadhyay,A., Lanahan,A.A., Zhuang,Z.W., Moodie,K.L., Mulligan-Kehoe,M.J., Byzova,T.V., Peterson,R.T., Simons,M. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. Journal of Clinical Investigation 2010; 120(-4-):1217-1228. >>> GS4898; Saline; DMSO; IP; Mice; 1002; 3, 7-14 days; Controls received mp w/ vehicle; cardiovascular; enzyme inhibitor (PI3 kinase); animal info (wt, Synectin -/-, 8-10 weeks old; Ldlr-/- ApoB48-modified, 24 weeks old); ischemia (hindlimb).

Q0167 Sahara,M., Sata,M., Morita,T., Nakajima,T., Hirata,Y., Nagai,R. A Phosphodiesterase-5 Inhibitor Vardenafil Enhances Angiogenesis Through a Protein Kinase G-Dependent Hypoxia-Inducible Factor-1/Vascular Endothelial Growth Factor Pathway. Arterioscler Thromb Vasc Biol 2010; 30(--):1315-1324. >>> Vardenifil; PBS; SC; Mice; ; Controls received mp w/ vehicle; enzyme inhibitor (PDE5, phosphodiesterase-5); ischemia (hind limb); animal info (C57BL/6, C3H/He, 12-16 wks old, eNose -/-).

Q0350 Schmerbach,K., Pfab,T., Zhao,Y., Culman,J., Mueller,S., Villringer,A., Muller,D.N., Hocher,B., Unger,T., Thoene-Reineke,C. Effects of Aliskiren on Stroke in Rats Expressing Human Renin and Angiotensinogen Genes. PLoS One 2010; 5(-11-):U241-U247. >>> Aliskiren; candesartan; SC; Rat; 12 days; Controls received sham operation; animal info (dTGR, 5-6 wks old, 125-135g); MRI; ischemia (MCAO, cerebral).

Q0188 Toko,H., Takahashi,H., Kayama,Y., Okada,S., Minamino,T., Terasaki,F., Kitaura,Y., Komuro,I. ATF6 is important under both pathological and physiological states in the heart. Journal of Molecular and Cellular Cardiology 2010; 49(-1-):113-120. >>> Benzenesulfonyl fluoride, aminoethyl-; Mice; 14 days; Controls received mp w/ vehicle; cardiovascular; animal info (FVBNxC57BL/6, wt, Bcl-2 Tg, 8 weeks old, MI); ischemia (cardiac); ATF6 inhibitor.

Q0190 Troidl,C., Nef,H., Voss,S., Schilp,A., Kostin,S., Troidl,K., Szardien,S., Rolf,A., Schmitz-Rixen,T., Schaper,W., Hamm,C.W., Elsaesser,A., Moellmann,H. Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model. Journal of Molecular and Cellular Cardiology 2010; 49(-1-):142-151. >>> Phorbol didecanoate, 4-alpha-; IA (femoral); Pig; 2ML1; 7 days; Controls received mp w/ saline or sham operation; cardiovascular; animal info (male, juvenile, crossbred, 38kg, femoral artery occlusion); post op. care (cefquinome, fentanyl); ischemia (hind limb); excellent color photograph of multiple mp placement (Fig. 1); multiple pumps per animal (2).

Q0497 Yin,K.J., Deng,Z., Huang,H.R., Hamblin,M., Xie,C.Q., Zhang,J.F., Chen,Y.E. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. NEUROBIOLOGY OF DISEASE 2010; 38(-1-):17-26. >>> Oligonucleotide, antisense; CSF, artificial; CSF/CNS; Mice; 1003D; ; Negative controls received mp w/ miR-antagomir negative control or artificial CSF; antisense (miR-497); animal info (male, C57/Bl6); ischemia (focal cerebral).

Q0064 Yin,K.J., Deng,Z., Hamblin,M., Xiang,Y., Huang,H.R., Zhang,J.F., Jiang,X.D., Wang,Y.Z., Chen,Y.E. Peroxisome Proliferator-Activated Receptor-delta Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury. Journal of Neuroscience 2010; 30(-18-):6398-6408. >>> GW501516; CSF/CNS; Mice; 1003D; ; Controls received mp w/ vehicle; ischemia (cerebral).

P9399 Christensen,L.P., Zhang,R.L., Zheng,W., Campanelli,J.J., Dedkov,E.I., Weiss,R.M., Tomanek,R.J. Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapy. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-1-):H322-H330. >>> Ivabradine; Dextrose; IP; Rat; 4 weeks; Controls received mp w/ sterile distilled water; cardiovascular; ischemia (cardiac); animal info (male, Sprague Dawley, 12 months old, MI, 560 g.).

P9862 Gold,A.B., Keller,A.B., Perry,D.C. Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors. Brain Research 2009; 1250(-;-):88-100. >>> Nicotine; Rat (pregnant); 2002; 2004; ; Controls received mp w/saline; animal info (adult, pregnant, female, Sprague Dawley, PN10); "Osmotic minipumps were chosen to avoid spikes of high plasma nicotine concentrations and subsequent episodic fetal hypoxia/ischemia that can be produced by nicotine injections." pg. 97.

P9550 Hoang,S., Liauw,J., Choi,M., Choi,M., Guzman,R.G., Steinberg,G.K. Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 2009; 29(-2-):385-397. >>> Netrin, recomb. mouse; CSF, artificial; CSF/CNS; Mice; 1003D; ; Controls received mp w/vehicle; ischemia (focal cerebral); animal info (adult, male, C57BL/6J, 30-35g); brain tissue distribution; aCSF recipe.

P9412 Houng,A.K., McNamee,R.A., Kerner,A., Sharma,P., Mohamad,A., Tronolone,J., Reed,G.L. Atrial natriuretic peptide increases inflammation, infarct size, and mortality after experimental coronary occlusion. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-3-):H655-H661. >>> Atrial natriuretic peptide, mouse; SC; Mice; 1002; 12 days; Controls received no treatment; cardiovascular; peptides; animal info (male, C57BL/6, wt, ANP -/-, 6-24 wks old, MI); ischemia (cardiac).

Q0044 Huang,B.S., Ahmad,M., Tan,J.H., Leenen,F.H.H. Chronic central versus systemic blockade of AT1 receptors and cardiac dysfunction in rats post-myocardial infarction. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-3-):H968-H975. >>> Losartan; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; animal info (Wistar, 200-250 g, MI); ischemia (cardiac); comparison of SC injections vs. mp.

Q0588 Keiner,S., Witte,O.W., Redecker,C. Immunocytochemical Detection of Newly Generated Neurons in the Perilesional Area of Cortical Infarcts After Intraventricular Application of Brain-Derived Neurotrophic Factor. Journal of Neuropathology and Experimental Neurology 2009; 68(-1-):83-93. >>> Brain-derived neurotrophic factor; NaCl; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (male, Wistar, 12-14 weeks, 250-300 g); functionality of mp verified by residual volume; ALZET brain infusion kit 2 used; ischemia (focal cortical infarct); behavioral testing (the limb-use asymmetry; tapered beam walking; ladder rung walking); fig. 1c diagram of a parasagittal section of the rat brain showing cannula placement.

P9843 Oya,S., Yoshikawa,G., Takai,K., Tanaka,J.I., Higashiyama,S., Saito,N., Kirino,T., Kawahara,N. ATTENUATION OF Notch SIGNALING PROMOTES THE DIFFERENTIATION OF NEURAL PROGENITORS INTO NEURONS IN THE HIPPOCAMPAL CA1 REGION AFTER ISCHEMIC INJURY. Neuroscience 2009; 158(-2-):683-692. >>> Epidermal growth factor, recomb. human; fibroblast growth factor, recomb. human; Jag1, recomb. rat; S2188; DLL4, recomb. mouse; CSF, artificial, DMSO; CSF/CNS; Rat; 1003D; 1007D; 11 days; Controls received mp w/ vehicle; pumps replaced after 3 days; enzyme inhibitor (gamma secretase); animal info (male, Wistar, adult, 8 wks old, 280-320 g.); ischemia (cerebral); bilateral infusion; 10% DMSO used; brain tissue distribution.

Q0262 Sakata,A., Mogi,M., Iwanami,J., Tsukuda,K., Min,L.J., Fujita,T., Iwai,M., Ito,M., Horiuchi,M. Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function. Brain Research 2009; 1300(-;-):14-23. >>> Valsartan; IP; Mice; 1002; ; Controls received mp w/ vehicle; animal info (adult C57BL/6, Agtr2-, Agtr2+, 3-4 mo old, male, female); behavioral testing (Morris water maze test); ischemia (cerebral).

P9850 Simard,J.M., Yurovsky,V., Tsymbalyuk,N., Melnichenko,L., Ivanova,S., Gerzanich,V. Protective Effect of Delayed Treatment With Low-Dose Glibenclamide in Three Models of Ischemic Stroke. Stroke 2009; 40(-2-):604-609. >>> Glibenclamide; DMSO; SC; Rat; 2001; ; Animal info (Wistar, MCAO, 250-300 g.); delayed treatment using attached catheter filled with air; ischemia (cerebral).

P9450 Takenaka,H., Horiba,M., Ishiguro,H., Sumida,A., Hojo,M., Usui,A., Akita,T., Sakuma,S., Ueda,Y., Kodama,I., Kadomatsu,K. Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-2-):H462-H469. >>> Midkine, recomb. human; Saline; SC; Mice; 7-28 days; Controls received mp w/ vehicle; pump replaced every 7 days; cardiovascular; peptides; ischemia (cardiac); animal info (male, C57BL/6, MK-KO, wt, 10-12 wks old, 22-25 g., MI); angiogenesis.

P9466 Xing,J.H., Lu,J., Li,J.H. Contribution of nerve growth factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology 2009; 296(-5-):H1380-H1387. >>> Nerve growth factor; SC; Rat; 1003D; 72 hours; Controls received mp w/ saline to contralateral leg; cardiovascular; peptides; multiple pumps per animal (2); ischemia (muscle); animal info (male, Sprague Dawley, 5-7 wks old); SC in the hindlimb.

Q0488 Yan,Y.P., Lang,B.T., Vemuganti,R., Dempsey,R.J. Galectin-3 mediates post-ischemic tissue remodeling. Brain Research 2009; 1288(-;-):116-124. >>> Antibody, anti Gal-3, normal, mouse; CSF, artificial; CSF/CNS (ipsilateral striatum); Rat; 1007D; 7 days; Controls received mp w/vehicle and sham surgery; animal info (adult, male, SHR, 270-320 g, MCAO); ischemia (cerebral); artificial CSF recipe, pg 122.

Q0760 Yan,Y.P., Lang,B.T., Vemuganti,R., Dempsey,R.J. Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia. NEUROCHEMISTRY INTERNATIONAL 2009; 55(-8-):826-832. >>> Antibody, anti-OPN, mouse; Antibody, normal, mouse; CSF, artificial; CSF/CNS (striatum); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (adult, male, SHR, focal ischemia, MCAO, 270-320 g); aCSF recipe.

P9767 Zhang,Q., Chen,C., Lue,J.G., Xie,M.J., Pan,D.J., Luo,X., Yu,Z.Y., Dong,Q., Wang,W. Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1-beta, MIP-1-alpha, and NO After Focal Cerebral Ischemia in the Rat. Glia 2009; 57(-8-):908-920. >>> Roscovitine; DMSO; saline; CSF/CNS; Rat; 2001; ; Controls received mp w/vehicle; functionality of mp verified by "weighing the cassette before placement and after the experiment" pg. 909; enzyme inhibitor (cyclin dependant kinase); ALZET brain infusion kit used; ischemia (cerebral); animal info (adult, male, Sprague Dawley, 220-270 g); 0.2% DMSO used; MCAO.

P9390 Berner,J., Ringstedt,T., Brodin,E., Hoekfelt,T., Lagercrantz,H., Wickstroem,R. Prenatal Exposure to Nicotine Affects Substance P and Preprotachykinin-A mRNA Levels in Newborn Rat. PEDIATRIC RESEARCH 2008; 64(-6-):621-624. >>> Nicotine bitartrate; Saline; SC; Rat (pregnant); 2ML4; 17 days; Controls received mp w/ vehicle; no stress (see pg. 622); teratology; animal info (female, Sprague Dawley, gd5); "osmotic minipumps offer a safe route of administration and, unlike injected nicotine, do not cause any overt signs of hypoxia or ischemia, such as blanching of the skin or cyanosis, nor are there any long term changes in maternal blood pressure or heart rate." (p. 622).

P8833 Boodhwani,M., Voisine,P., Rue,M., Sodha,N.R., Feng,J., Xu,S.H., Bianchi,C., Settke,F.W. Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction. European Journal of Cardio-thoracic Surgery 2008; 33(-4-):645-650. >>> Vascular endothelial growth factor 165, recomb. human; Heparin; Intramyocardial; Pig (miniswine); 2ML4; 4 weeks; Tissue perfusion (myocardial); half-life (p. 649) "short"; cardiovascular; peptides; ischemia (cardiac); animal info (Yucatan mini-swine, 20-30 kg.).

P9341 Callaway,C.W., Ramos,R., Logue,E.S., Betz,A.E., Wheeler,M., Repine,M.J. Brain-derived neurotrophic factor does not improve recovery after cardiac arrest in rats. Neuroscience Letters 2008; 445(-1-):103-107. >>> Brain-derived neurotrophic factor; CSF/CNS; Rat; 1003D; ; Controls received mp w/ saline; saline filled pumps replaced after cardiac arrest w/ BDNF filled pumps; ischemia (cerebral); PE-50 tubing used; bilateral infusion via 25 g injectors.

Q0037 Clark,S.R., McMahon,C.J., Gueorguieva,I., Rowland,M., Scarth,S., Georgiou,R., Tyrrell,P.J., Hopkins,S.J., Rothwell,N.J. Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. Journal of Cerebral Blood Flow and Metabolism 2008; 28(-2-):387-394. >>> Interleukin-1 receptor antagonist, recomb. met human; IV (jugular); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, MCAO); ischemia (cerebral); functionality of mp verified by CSF and plasma IL-1RA levels.

P8933 Fujii,T., Yonemitsu,Y., Onimaru,M., Inoue,M., Hasegawa,M., Kuwano,H., Sueishi,K. VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis. Atherosclerosis 2008; 200(-1-):51-57. >>> Antibody, anti-VEGF; IP; Mice; 1007D; ; Ischemia (hind limb); animal info (male, C57BL/6, 6-7 wks old).

P9284 Griesbach,G.S., Hovda,D.A., Gomez-Pinilla,F., Sutton,R.L. Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats. Neuroscience 2008; 154(-2-):530-540. >>> Amphetamine sulfate; Saline, sterile; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; no stress (see pg. 535); post op. care (Bupivacaine, antibiotic ointment); ischemia (cerebral); animal info (male, Sprague Dawley, 285 g., CCI injury); behavioral testing (voluntary wheel exercise); "This drug administration method was chosen since our prior studies of RW exposure after TBI have left animals undistrurbed for the 1 week exercise period." (p. 530).

R0254 Hasko,G., Pacher,P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. Journal of Leukocyte Biology 2008; 83(-3-):447-455. >>> ATL146c; Rat; mice; rabbit; ; Replacement therapy (STZ-induced diabetes); ischemia (renal, hepatic); review, see ref #'s 79, 90, 91, 92, 93, 95.

P8887 Hu,A.H., Jiao,X.Y., Gao,E.H., Li,Y.H., Sharifi-Azad,S., Grunwald,Z., Ma,X.L., Sun,J.Z. Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart. REJUVENATION RESEARCH 2008; 11(-1-):215-226. >>> 1400W; Isoproterenol bitartrate; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (iNOS); animal info (C57BL/6, 3, 20 months old); ischemia (myocardial).

P9420 Kimura,A., Ohmori,T., Kashiwakura,Y., Ohkawa,R., Madoiwa,S., Mimuro,J., Shimazaki,K., Hoshino,Y., Yatomi,Y., Sakata,Y. Antagonism of Sphingosine 1-Phosphate Receptor-2 Enhances Migration of Neural Progenitor Cells Toward an Area of Brain Infarction. Stroke 2008; 39(-12-):3411-3417. >>> JTE-013; DMSO; PBS; CSF/CNS; Mice; 1002; 12 days; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; ischemia (cerebral); animal info (female, C57BL/6, 8-12 wks old, MCAO); dental cement used; cannula placement confirmed post mortem; "Cannula placement was verified by direct observation by cutting aninsertion point."; JTE-013 is a spingosine-1-phosphate 2 receptor inhibitor.

P9211 LaMarca,B., Wallukat,G., Llinas,M., Herse,F., Dechend,R., Granger,J.P. Autoantibodies to the Angiotensin Type I Receptor in Response to Placental Ischemia and Tumor Necrosis Factor-alpha in Pregnant Rats. Hypertension 2008; 52(-6-):1168-1172. >>> Tumor necrosis factor-a; Rat (pregnant); 2002; 5 days; Functionality of mp verified by serum TNFa levels; cardiovascular; peptides; ischemia (placental); animal info (female, Sprague Dawley, gd 14-19).

P9258 Leskinen,H., Rauma-Pinola,T., Szokodi,I., Kerkelae,R., Pikkarainen,S., Uusimaa,P., Hautala,T., Vuolteenaho,O., Ruskoaho,H. Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context-dependent in the heart. JOURNAL OF GENE MEDICINE 2008; 10(-8-):867-877. >>> Angiotensin II; SC; Rat; 2001; 2002; 3-14 days; Controls received mp no agent infusion; cardiovascular; peptides; post op. care (buprenorphine hydrochloride) ischemia (cardiac); animal info (male, Sprague Dawley, MI).

P8877 Li,J.M., Mogi,M., Iwanami,J., Min,L.J., Tsukuda,K., Sakata,A., Fujita,T., Iwai,M., Horiuchi,M. Temporary pretreatment with the angiotensin II type 1 receptor blocker, valsartan, prevents ischemic brain damage through an increase in capillary density. Stroke 2008; 39(-7-):2029-2036. >>> Valsartan; IP; Mice; 1002; 2 weeks; Ischemia (cerebral); animal info (male, C57BL/6, 6 wks old, 20 g.); middle cerebral artery occlusion.

P9216 Lin,J.S., Chen,Y.S., Chiang,H.S., Ma,M.C. Hypoxic preconditioning protects rat hearts against ischaemia-reperfusion injury: role of erythropoietin on progenitor cell mobilization. JOURNAL OF PHYSIOLOGY-LONDON 2008; 586(-23-):5757-5769. >>> Antibody, polyclonal anti-EPO receptor; immunoglobulin G, rabbit; SC; Rat; 2004; 28 days; Controls received mp w/ rabbit IgG; cardiovascular; ischemia (cardiac MI); animal info (female, Wistar, 200-220 g., hypoxic).

P8934 Lu,J., Zhang,Y.D., Shi,J.P. Effects of intracerebroventricular infusion of angiotensin-(1-7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia-reperfusion in rats. Brain Research 2008; 1219(-;-):127-135. >>> Angiotensin (1-7); CSF, artificial; CSF/CNS; Rat; 1007D; ; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; peptide; ischemia (cerebral); animal info (male, Sprague Dawley, 280-300 g.); MCAO.

P8932 Oya,S., Yoshikawa,G., Takai,K., Tanaka,J.I., Higashiyama,S., Saito,N., Kirino,T., Kawahara,N. Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia. NeuroReport 2008; 19(-8-):805-810. >>> Epidermal growth factor, recomb. human; fibroblast growth factor-2, recomb. human; insulin-like growth factor I, recomb. human; erythropoietin, recomb. rat; brain-derived neurotrophic factor, recomb. human; DDL4, recomb. mouse; CSF/CNS; Rat; 1003D; 3 days; Ischemia; animal info (male, Wistar, 8wks old, 280-300 g.); bilateral infusion.

P9184 Oyamada,N., Sone,M., Miyashita,K., Park,K., Taura,D., Inuzuka,M., Sonoyama,T., Tsujimoto,H., Fukunaga,Y., Tamura,N., Itoh,H., Nakao,K. The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia. Endocrinology 2008; 149(-8-):3764-3777. >>> Spironolactone; Propylene glycol; Mice; 2002; 7 or 14 days; Controls received mp w/ vehicle; animal info (male, adult, 8 wks old, 20-22 g.); common left carotid artery ligation; ischemia (cerebral).

P8789 Park,K., Itoh,H., Yamahara,K., Sone,M., Miyashita,K., Oyamada,N., Sawada,N., Taura,D., Inuzuka,M., Sonoyama,T., Tsujimoto,H., Fukunaga,Y., Tamura,N., Nakao,K. Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases. Endocrinology 2008; 149(-2-):483-491. >>> Carperitide; Water; IP; Mice; 1002; 28 days; Controls received mp w/ vehicle; STZ-induced Diabetes; pumps replaced after 14 days; ischemia (hind limb); animal info (male, C57BL/6, 8 wks old, femoral artery ligation); Carperitide is a recomb. human ANP.

P9195 Patzer,A., Zhao,Y., Stoeck,I., Gohlke,P., Herdegen,T., Culman,J. Peroxisome proliferator-activated receptors gamma; (PPAR gamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. European Journal of Neuroscience 2008; 28(-9-):1786-1794. >>> Pioglitazone; DMSO; saline; CSF/CNS; Rat; 2002; 6 or 7 days; Controls received mp w/ vehicle; animal info (male, normotensive, Wistar, MCAO, 220-250 g.); 50% DMSO used; middle cerebral artery occlusion; ischemia (cerebral).

P9266 Puchowicz,M.A., Zechel,J.L., Valerio,J., Emancipator,D.S., Xu,K., Pundik,S., LaManna,J.C., Lust,W.D. Neuroprotection in diet-induced ketotic rat brain after focal ischemia. Journal of Cerebral Blood Flow and Metabolism 2008; 28(-12-):1907-1916. >>> Butyrate, sodium-B-hydroxy-; propionate; nitropropionic acid, 3-; Saline, normal; CSF/CNS; Rat; 2001; 4 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; ischemia (cerebral); animal info (male Wistar, 28 days old, 110 g., MCAO); neurodegenerative (Alzheimer's, Parkinson's, Freidereich's ataxia, ALS, stroke).

P9301 Sallinen,P., Maenataerri,S., Leskinen,H., Vakkuri,O., Ruskoaho,H., Saarela,S. Long-term postinfarction melatonin administration alters the expression of DHPR, RyR2, SERCA2, and MT2 and elevates the ANP level in the rat left ventricle. Journal of Pineal Research 2008; 45(-1-):61-69. >>> Melatonin; PEG 400; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; no stress (see pg. 62); cardiovascular; ischemia (cardiac); animal info (male, Sprague Dawley, 240-290 g., MI); "28-day subcutaneous infusion of melatonin in rats had no obvious toxicity or side effects." (p. 62).

P9676 Smith,RS Jr, Gao,L., Chao,L., Chao,J. Tissue kallikrein and kinin infusion promotes neovascularization in limb ischemia. BIOLOGICAL CHEMISTRY 2008; 389(-6-):725-730. >>> Kallikrein, tissue; bradykinin; bradykinin, des-Arg-; PBS; SC; Rat; 2 weeks; Controls received mp w/ vehicle; ischemia (hindlimb); animal info (male, Wistar, 200 g.); "a continuous supply of TK/kinin using protein delivery can induce therapeutic angiogenesis in rat model of hindlimb ischemia" pg. 729.

P9298 Takeo,S., Takagi,N., Takagi,K., Date,I., Ishida,K., Besshoh,S., Nakamura,T., Tanonaka,K. Hepatocyte growth factor suppresses ischemic cerebral edema in rats with microsphere embolism. Neuroscience Letters 2008; 448(-1-):125-129. >>> Hepatocyte growth factor, recomb. human; Saline, physiological; CSF/CNS; Rat; 2001; 3 days; Controls received no treatment; peptides; ischemia (cerebral); animal info (male, Wistar, 220-250 g.).

P9452 Teschendorf,P., Vogel,P., Wippel,A., Krumnikl,J.J., Spoehr,F., Boettiger,B.W., Popp,E. The effect of intracerebroventricular application of the caspase-3 inhibitor zDEVD-FMK on neurological outcome and neuronal cell death after global cerebral ischaemia due to cardiac arrest in rats. RESUSCITATION 2008; 78(-1-):85-91. >>> Z-DEVD-FMK; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ artificial CSF; no stress (see pg. 87); enzyme inhibitor (caspase-3); cardiovascular; ischemia (cardiac, cerebral); animal info (male, Wistar, 350-450 g., cardiac arrest); Z-DEVD-FMK also known as N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone.

P9269 Wang,L., Kitano,H., Hurn,P.D., Murphy,S.J. Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain. Journal of Cerebral Blood Flow and Metabolism 2008; 28(-11-):1824-1834. >>> Pyrazole triol, propyl-; diarylpropionitrile; DMSO; saline; SC; Mice; 1002; 10 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); no stress (see pg. 1828-1829); ischemia (cerebral); animal info (female, C57BL/6, 9-20 wks old, 20-25g, MCAO); 50% DMSO used; estrogen receptor agonists.

P9270 Wragg,A., Mellad,J.A., Beltran,L.E., Konoplyannikov,M., San,H., Boozer,S., Deans,R.J., Mathur,A., Lederman,R.J., Kovacic,J.C., Boehm,M. VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism. JOURNAL OF MOLECULAR MEDICINE-JMM 2008; 86(-11-):1221-1232. >>> AMD 3100; Rat; 2 weeks; Controls received no treatment; cardiovascular; ischemia (hind limb); animal info (female, Fisher 344, 12-14 wks old); CXCR4-specific receptor antagonist.

P9275 Wu,T.W., Li,W.W., Li,H. NETRIN-1 ATTENUATES ISCHEMIC STROKE-INDUCED APOPTOSIS. Neuroscience 2008; 156(-3-):475-482. >>> Netrin-1; PBS; CSF/CNS; Mice; 1007D; 5, 7 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp; ALZET brain infusion kit 3 used; ischemia (cerebral); animal info (male, C57BL/6J, 10 wks old, MCAO).

P8468 Abe,Y., Ono,K., Kawamura,T., Wada,H., Kita,T., Shimatsu,A., Hasegawa,K. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. Am.J.Physiol Heart Circ.Physiol 2007/5; 292(-5-):H2387-H2396. >>> Leptin, recomb. mouse; SC; Mice; 2ML4; 4 weeks; Controls received mp w/ sterile PBS; no stress (see pg H2395); cardiovascular; peptides; animal info (C57/BL6, 12 wks old, MI coronary artery ligation); ischemia (cardiac).

P8555 Adamek,A., Hu,K., Bayer,B., Wagner,H., Ertl,G., Bauersachs,J., Frantz,S. High dose aspirin and left ventricular remodeling after myocardial infarction. Basic Research In Cardiology 2007; 102(-4-):334-340. >>> Acetylsalicylic acid, lysine; Saline; SC; Mice; 2002; 4 weeks; Controls received mp w/ placebo; functionality of mp verified by serum salicylate concentrations; pumps replaced after 2 weeks; cardiovascular; ischemia (cardiac); animal info (female, C57BL/6, 8-12 weeks old, 20-25 grams); MI induced by coronary artery ligation.

R0240 Bazan,N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2007; 10(-2-):136-141. >>> Neuroprotectin D1; CSF/CNS (third ventricle); Mice; ; Ischemia (cerebral); neurodegenerative (Alzheimer's disease); see pg. 137.

P8460 Bright,R., Steinberg,G.K., Mochly-Rosen,D. Delta PKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Research 2007; 1144(--):146-155. >>> TAT (47-57), dv1-1-; TAT (47-57); SC; Rat; 2ML2; 4-6 weeks; 6-7 days; Controls received mp w/ control peptide TAT; comparison of IP injections vs. mp; pumps replaced every 2 weeks; enzyme inhibitor (Protein kinase C); cardiovascular; peptides; ischemia (cerebral); animal info (11-12 wks old, male).

P8315 Clarkson,A.N., Clarkson,J., Jackson,D.M., Sammut,I.A. Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience 2007; 144(-2-):547-561. >>> Clomethiazole; SC; Rat; 2ML1; 5 days; Controls received mp w/ saline; no stress (see pg. 550); cardiovascular; ischemia (cerebral); animal info (male, Wistar, 24 days old, carotid artery ligation).

P8511 Clarkson,A.N., Liu,H., Schiborra,F., Shaw,O., Sammut,I.A., Jackson,D.M., Appleton,I. Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research 2007; 1171(--):111-121. >>> Clomethiazole; L-NAME; SC; Rat; 2ML1; 5 days; Controls received mp w/ vehicle or saline or no treatment; no stress (see pg. 112); enzyme inhibitor (NO synthase); ischemia (cerebral); animal info (male, Wistar, 21 days old).

P7979 Colonna,V.D.G., Bonomo,S., Ferrario,P., Bianchi,M., Berti,M., Guazzi,M., Manfredi,B., Muller,E.E., Berti,F., Rossoni,G. Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats. European Journal of Pharmacology 2007; 557(-2-3-):178-185. >>> Dimethylarginine, asymmetric; SC; Rat; 2ML2; 14 days; Blood pressure taken; plasma levels taken; ischemia (myocardial); animal info (male, Wistar, 280 grams).

P8299 Cruze,C.A., Su,F., Limberg,B.J., Deutsch,A.J., Stoffolano,P.J., Dai,H.J., Buchanan,D.D., Yang,H.T., Terjung,R.L., Spruell,R.D., Mittelstadt,S.W., Rosenbaum,J.S. The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency. Peptides 2007; 28(-2-):269-280. >>> Peptide YY, recomb. human; peptide YY (3-36), recomb. human; vascular endothelial growth factor 165; PBS; glycerol; sodium citrate; Tween 20; IA (iliac); Rat; 14 days; Controls received mp w/ vehicle; replacement therapy (femoral artery occlusion); dose-response (fig. 4); half-lfie (p. 276)<30 minutes; cardiovascular; peptides; ischemia (hindlimb); animal info (male, Sprague-Dawley, 325-350 grams).

P8569 Dedkov,E.I., Zheng,W., Christensen,L.P., Weiss,R.M., Mahlberg-Gaudin,F., Tomanek,R.J. Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen. Am.J.Physiol Heart Circ.Physiol 2007/7; 293(-1-):H590-H598. >>> Ivabradine; bromodeoxy; Dextrose; IP; Rat; 4 weeks; 2,6,13 days; 72 hours; Controls received mp w/ vehicle; multiple pumps per animal (2); animal info (male, Sprague-Dawley, 12 months old, MI); ischemia (cardiac).

P8814 Farr,T.D., Carswell,H.V.O., Gsell,W., Macrae,I.M. Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Research 2007; 1185(-;-):275-282. >>> Diarylpropiolnitrile; Saline; DMSO; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); stress/adverse reaction: (see pg. 277) infection in shoulder at mp tip (2 animals); MRI; post op. care (Baytril, Rimadyl); ischemia (cerebral); animal info (female, Lister Hooded, 180-200g., MCAO); "this strain was more susceptible to surgical wound infection than other strains" (p. 279); 50% DMSO used.

P8924 Gorio,A., Madaschi,L., Zadra,G., Marfia,G., Cavalieri,B., Bertini,R., Di Giulio,A.M. Reparixin, an inhibitor of CXCR2 function, attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord. Journal of Pharmacology and Experimental Therapeutics 2007; 322(-3-):973-981. >>> Reparixin; Saline; SC; Rat; 2ML1; 4, 7 days; Controls received mp w/ vehicle; dose-response (fig. 7); comparison of SC injections vs. mp; half-life (p.978) 0.5 hours in rats; ischemia (cerebral); animal info (male, Sprague Dawley, SCI, 240-260 g.); "The requirement of multiple doses of reparixin treatment to promote functional recovery after SCI in rats suggests that administration by continuous infusion could be the optimal schedule of treatment." (p.977).

P8627 Huang,B.S., Ahmad,M., Tan,J., Leenen,F.H.H. Sympathetic hyperactivity and cardiac dysfunction post-MI: Different impact of specific CNS versus general AT1 receptor blockade. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):479-486. >>> Losartan; spironolactone; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; comparison of SC injections vs. mp; no stress (see pg. 483); cardiovascular; ischemia (cardiac); animal info (male, wistar, 200-250g, coronary artery ligation MI).

P8428 Iwashita,A., Muramatsu,Y., Yamazaki,T., Muramoto,M., Kita,Y., Yamazaki,S., Mihara,K., Moriguchi,A., Matsuoka,N. Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective Agonists in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics 2007; 320(-3-):1087-1096. >>> L-165041; GW501516; PEG 300; saline; DMSO; CSF/CNS; Rat; mice; 1003D; 1007D; 2, 6 days; Controls received mp w/ vehicle; dose-response (fig. 6); cardiovascular; ischemia (cerebral); animal info (male, Wistar, 9-10 wks old, 250-280 g.; male, C57/BL6, 9-10 wks old, 19-22g.); neurodegenerative (Parkinson's disease); Right middle cerebral artery occlusion; 30% DMSO.

P8656 Jesmin,S., Maeda,S., Mowa,C.N., Zaedi,S., Togashi,H., Prodhan,S.H., Yamaguchi,T., Yoshioka,M., Sakuma,I., Miyauchi,T., Kato,N. Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat. European Journal of Pharmacology 2007; 574(-2-3-):158-171. >>> SB209670; Saline; SC; Rat; 2ML4; 12 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 4 weeks; ischemia (cerebral); animal info (SHRSP, WKY, 6 wks old); endothelin dual receptor antagonist.

P8618 Kanamori,H., Takemura,G., Li,Y., Okada,H., Maruyama,R., Aoyama,T., Miyata,S., Esaki,M., Ogino,A., Nakagawa,M. Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan. American Journal of Physiology- Heart and Circulatory Physiology 2007; 292(-5-):H2184-H2194. >>> Hydralazine; olmesartan; SC; Mice; 4 weeks; 7 days; Controls received mp w/ saline; cardiovascular; animal info (male, C57BL/6J, 10 weeks old, left coronary artery ligation; ischemia (cardiac).

Q0248 Kolb,B, Morshead,C., Gonzalez,C., Kim,M., Gregg,C., Shingo,T., Weiss,S. Growth factor-stimulated generation of newcortical tissue and functional recovery after strokedamage to the motor cortex of rats. Journal of Cerebral Blood Flow and Metabolism 2007; 27(--):983-997. >>> Erythropoietin; epidermal growth factor; CSF, artificial; CSF/CNS; Rat; 2001; 7, 14 days; Controls received mp w/ vehicle; peptides; animal info (male, Long-Evans, 90-110 days old); ischemia (cerebral); behavioral testing (forelimb assymetry, forelimb inhibition (swimming), reaching); some animals received 7 days EGF.

P8253 Leker,R.R., Soldner,F., Velasco,I., Gavin,D.K., ndroutsellis-Theotokis,A., McKay,R.D.G. Long-lasting regeneration after ischemia in the cerebral cortex. Stroke 2007; 38(-1-):153-161. >>> Ara-C; Saline; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; ischemia (cerebral); animal info (SHR, permanent distal middle cerebral artery occlusion).

P8529 Li,P.L., Ogino,K., Hoshikawa,Y., Morisaki,H., Cheng,J.D., Toyama,K., Morisaki,T., Hashimoto,K., Ninomiya,H., Tomikura-Shimoyama,Y., Igawa,O., Shigemasa,C., Hisatome,I. Remote Reperfusion lung injury is associated with AMP deaminase 3 activation and attenuated by inosine monophosphate. CIRCULATION JOURNAL 2007; 71(-4-):591-596. >>> Inosine monophosphate; Saline; SC; Mice; 2001D; 18 hours; Controls received mp w/ vehicle; cardiovascular; ischemia (skeletal muscle); animal info (male, BALBC, 6-8 weeks old).

P9378 Lorentzon,M., Raamunddal,T., Bollano,E., Soussi,B., Waagstein,F., Omerovic,E. Vivo effects of myocardial creatine depletion on left ventricular function, morphology, and energy metabolism - Consequences in acute myocardial infarction. JOURNAL OF CARDIAC FAILURE 2007; 13(-3-):230-237. >>> Guanidinopropionic acid, beta-; Saline; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; no stress (see pg. 231, 233); animal info (male, Sprague Dawley, 6 wks old, 200 g., MI); ischemia (cardiac); "No local adverse skin reaction in the area of implanted osmotic minipumps was observed in the BGP group suggesting good tolerance of this novel BGP application route." (p. 233).

P8635 Milkiewicz,M., Doyle,J.L., Fudalewski,T., Ispanovic,E., Aghasi,M., Haas,T.L. HIF-1 alpha and HIF-2 alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. JOURNAL OF PHYSIOLOGY-LONDON 2007; 583(-2-):753-766. >>> DMAG, 17-; Dextrose, sterile; SC; IM (extensor digitorum longus); Rat; 2002; 7, 14 days; Controls received mp w/ vehicle; enzyme inhibitor (Hsp 90); post op. care (butorphanol); ischemia (muscle); animal info (male, Sprague-Dawley, 200-250g); agent also known as NSC 707545, a geldanamycin derivative.

P8539 Morimoto,H., Takahashi,M., Shiba,Y., Izawa,A., Ise,H., Hongo,M., Hatake,K., Motoyoshi,K., Ikeda,L. Bone marrow-derived CXCR4+ cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice. American Journal of Pathology 2007; 171(-3-):755-766. >>> AMD 3100; Saline; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; replacement therapy (splenectomy); cardiovascular; ischemia (cardiac); animal info (C57BL/6J, male, 8-12 weeks old).

P8541 Muramatsu,Y., Furuichi,Y., Tojo,N., Moriguchi,A., Maemoto,T., Nakada,H., Hino,M., Matsuoka,N. Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models. Brain Research 2007; 1149(--):181-190. >>> Cyclosporin A; FR901459; Cremophor EL; saline;; CSF/CNS; Rat; 1003D; 48 hours; Dose-response (fig. 7); comparison of IV bolus injections vs. mp; ischemia (cerebral); animal info (male, Wistar, 9-10 weeks old, 274-280 grams, MCAO).

P8080 Nagano,H., Wei,P.Z., Wen,C.Q., Jomori,T., Oku,H., Ikeda,T., Saito,Y., Tano,Y. Effects of kallidinogenase on ischemic changes induced by repeated intravitreal injections of endothelin-1 in rabbit retina. Current Eye Research 2007; 32(-2-):113-122. >>> Kallidinogenase; Saline; IV (marginal ear vein); Rabbit; 4 weeks; Controls received mp w/ vehicle; ischemia (retinal); animal info (male, New Zealand, 2.5-3.5 kg.).

P8726 Nitescu,N., Grimberg,E., Ricksten,S.E., Marcussen,N., Guron,G. Thrombin inhibition with melagatran does not attenuate renal ischaemia-reperfusion injury in rats. NEPHROLOGY DIALYSIS TRANSPLANTATION 2007; 22(-8-):2149-2155. >>> Melagatran; Saline; SC; Rat; 1003D; 48 hours; Controls received mp w/ vehicle; plasma levels taken; ischemia (renal artery); animal info (male, Sprague-Dawley, 250g); thrombin inhibitor.

P8976 Park,S.W., Yan,Y.P., Satriotomo,I., Vemuganti,R., Dempsey,R.J. Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. Journal of Neurosurgery 2007; 107(-3-):593-599. >>> Substance P; L703,606; CSF, artificial; CSF/CNS; Rat; 2001; 5 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; peptides; ischemia (cerebral); animal info (male, SHR, MCAO, 250-350 g.); NK1R antagonist.

P8601 Physiologica,A. Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ACTA PHYSIOLOGICA 2007; 190(-4-):339-350. >>> Losartan; IP; Rat; 2ML2; 14 days; Controls received no treatment; cardiovascular; post op. care (buprenorphine); ischemia (cardiac); animal info (male, Wistar, 250 grams, left anterior descending coronary artery ligation).

P8643 Simard,J.M., Tsymbalyuk,O., Ivanov,A., Ivanova,S., Bhatta,S., Geng,Z.H., Woo,S.K., Gerzanich,V. Endothelial sulfonylurea receptor 1- regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. Journal of Clinical Investigation 2007; 117(-8-):2105-2113. >>> Glibenclamide; oligodeoxynucleotide, phosphorothioate missense; repaglinide; oligodeoxynucleotide, antisense; oligodeoxynucleotide, phosphorothioate antisense; oligodeoxynucleotide, missense; Saline; PBS; DMSO; SC; IV (jugular); CSF/CNS (parietal lobe); Rat; 2002; 1, 7, 10-14 days; Controls received mp w/ vehicle; antisense (Abcc8); ischemia (cerebral); animal info (female, Long-Evans, 275-350g, acute SCI); "We used constant infusion of a low dose of drug to achieve sustained occupancy of only high-affinity receptors." (p. 2109).

P8619 Stoller,D., Kakkar,R., Smelley,M., Chalupsk,K., Earley,J.U., Shi,N.Q., Makielski,J.C., McNally,E.M. Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress. Journal of Molecular and Cellular Cardiology 2007; 43(-4-):445-454. >>> Nifedipine; DMSO; IP; Mice; 1002; >7 days; Controls received no treatment; functionality of mp verified by mp examination; cardiovascular; ischemia (cardiac); animal info (male, SUR2 -/-, wt FVB, 12-18 weeks old).

P8497 Strbian,D., Karjalainen-Lindsberg,M.L., Kovanen,P.T., Tatlisumak,T., Lindsberg,P.J. Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circulation 2007; 116(-4-):411-418. >>> Cromoglycate; CSF/CNS; Rat; 2001; ; ALZET brain infusion kit 2 used; ischemia (cerebral); animal info (13-14 weeks old).

P8900 Torregrosa,G., Perez-Asensio,F.J., Burguete,M.C., Castello-Ruiz,M., Salom,J.B., Alborch,E. Chronic intracerebroventricular delivery of the secretory phospholipase A(2) inhibitor, 12-epi-scalaradial, does not improve outcome after focal cerebral ischemia-reperfusion in rats. Experimental Brain Research 2007; 176(-2-):248-259. >>> Scalaradial, 12-epi-; Ethanol; cyclodextrin, 2-hydroxypropyl-B-; CSF/CNS; Rat; 2001; 4 days; Controls received mp w/ vehicle; dose-response (fig. 2); enzyme inhibitor (secretory phospholipase A2); ALZET brain infusion kit used; ischemia (cerebral); animal info (male, Wistar, 300-350 g., MCAO); 10% ethanol used; behavioral testing (locomotor activity, parachute reflex, forepaw stretching resistance); 13.5% cyclodextrin used.

P8609 Tsai,S.Y., Markus,T.M., Andrews,E.M., Cheatwood,J.L., Emerick,A.J., Mir,A.K., Schwab,M.E., Kartje,G.L. Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke. Experimental Brain Research 2007; 182(-2-):261-266. >>> Antibody, anti-Nogo-A monoclonal; antibody, immunoglobulin G 1, anti-wheat auxin; CSF/CNS (intrathecal, lumbar); Rat; 2ML2; 2 weeks; Controls received mp w/ IgG1 or no treatment; brain tissue distribution; animal info (male, Long-Evans, 300 grams, MCAO); ischemia (cerebral); "anti-Nogo-A immunotherapy delivered through the more accessible intrathecal route is an effective way to restore neurological function following stroke." (p. 265).

Q0254 Yan,Y.P., Sailor,K.A., Lang,B.T., Park,S.W., Vemuganti,R., Dempsey,R.J. Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 2007; 27(-6-):1213-1224. >>> Monocyte chemoattractant protein-1; CSF, artificial; BSA; CSF/CNS (striatum); in vitro (neurospheres); Rat; 1003D; 2001; 3, 7 days; Controls received sham operation; peptdies; cardiovascular; animal info (SHR, 270-300g); ischemia (cerebral); dose-response (fig. 5); in vitro MCP-1 administration to neurospheres in a culture plate was performed by submerging mp in normal saline in an adjacent well in the culture plate, connected via catheter (see fig. 5D).

P9268 Yao,Y.Y., Yin,H., Shen,B., Chao,L., Chao,J.L. Tissue kallikrein and kinin infusion rescues failing myocardium after myocardial infarction. JOURNAL OF CARDIAC FAILURE 2007; 13(-7-):588-596. >>> Kallikrein; bradykinin; SC; Rat; 4 weeks; Controls received mp w/ saline; functionality of mp verified by elevated circulating tissue Kallikrein levels; cardiovascular; peptides; ischemia (cardiac); animial info (male, Wistar, 220-250 g., MI).

P8273 Yao,Y.Y., Yin,H., Shen,B., Chao,L., Chao,J. Tissue kallikrein infusion prevents cardiornyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction. REGULATORY PEPTIDES 2007; 140(-1-2-):12-20. >>> Kallikrein, rat tissue; icatibant; Saline; SC; Rat; 7 days; Controls received mp w/ vehicle; functionality of mp verified by plasma TK levels; comparison of intramyocardial injections vs. mp; cardiovascular; peptides; ischemia (cardiac); animal info (male, Wistar, 250-280 g, left coronary artery ligation); "The advantage of kallikrein protein infusion via osmotic minipumps is to provide a stable supply of the therapeutic protein or peptide without potential side effects." (p. 18); "Kallikrein protein infusion has advantages over adenovirus-mediated delivery." (p. 18).

P8903 Zhang,L.N., da Cunha,V., Martin-McNulty,B., Rutledge,J., Vergona,R., Sullivan,M.E., Wang,Y.X.J. Monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha; a deficiency does not affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model. CARDIOVASCULAR PATHOLOGY 2007; 16(-4-):231-236. >>> Angiotensin II; PBS; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; cardiovascular; peptides; ischemia (cardiac); animal info (male, C57BL/6, MCP-1, MIP-1a-deficient, 6 months); common left carotid artery ligation.

P8742 Zhang,W.R., Koerner,I.P., Noppens,R., Grafe,M., Tsai,H.J., Morisseau,C., Luria,A., Hammock,B.D., Falck,J.R., Alkayed,N.J. Soluble epoxide hydrolase: a novel therapeutic target in stroke. Journal of Cerebral Blood Flow and Metabolism 2007; 27(-12-):1931-1940. >>> MS-PPOH; SC; Mice; 2001D; 24 hours; Enzyme inhibitor (p45D epoxygenase; ischemia (cerebral); animal info (C57BL/6, 20-26g, MCAO); N-methylsultonyl-6-(2-propargyloxyphenyl) hexanamide.