References on Intrathecal Administration of Agents Using ALZET^® Osmotic Pumps

Q0784 Calvo,M., Zhu,N., Grist,J., Ma,Z.Z., Loeb,J.A., Bennett,D.L.H. Following Nerve Injury Neuregulin-1 Drives Microglial Proliferation and Neuropathic Pain via the MEK/ERK Pathway. Glia 2011; 59(-4-):554-568. >>> PD168393; DMSO; CSF/CNS (intrathecal, subsubarachnoid space); Rat; 2002; ; Controls received mp w/ vehicle; animal info (male, Wistar, adult); 5% DMSO used.

Q0682 Cirillo,G., Bianco,M.R., Colangelo,A.M., Cavaliere,C., Daniele,D., Zaccaro,L., Alberghina,L., Papa,M. Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor. NEUROBIOLOGY OF DISEASE 2011; 41(-3-):630-639. >>> Nerve growth factor, beta, recomb.; GM6001; CSF, artificial; albumin, rat serum; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (Sprague-Dawley, male, 250-300 g); enzyme inhibitor (metalloproteinase); PE10 connected to PE60 tubing.

Q0914 Hayashi,M., Kamiya,Y., Itoh,H., Higashi,T., Miyazaki,T., Funakoshi,K., Yamashita,N., Goshima,Y., Andoh,T., Yamada,Y., Goto,T. Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve. NEUROSCIENCE RESEARCH 2011; 69(-1-):17-24. >>> Sema3A; Saline; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (Sprague-Dawley, male, 220-300 g); neuropathic pain.

Q0832 Kobayashi,A., Shinoda,M., Sessle,B.J., Honda,K., Imamura,Y., Hitomi,S., Tsuboi,Y., Okada-Ogawa,A., Iwata,K. Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats. Molecular Pain 2011; 7(-;-):U1-U11. >>> PD98059; fluoroacetate; DMSO; CSF/CNS (spinal cord, intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Sprague Dawley, 200-300 g); enzyme inhibitor (mitogen-activated protein kinase, MEK 1/2); 10% DMSO used.

Q0788 Nakamura,Y., Fujita,Y., Ueno,M., Takai,T., Yamashita,T. Paired Immunoglobulin-like Receptor B Knockout Does Not Enhance Axonal Regeneration or Locomotor Recovery after Spinal Cord Injury. Journal of Biological Chemistry 2011; 286(-3-):1876-1883. >>> NEP1-40; DMSO; PBS; CSF/CNS (intrathecal); Mice; 2002; 14 days; Controls received mp w/ vehicle; animal info (C57BL/6J, 8 wks old, PIR-B-/-); NEP1-40 is a NgR antagonist peptide; 17% DMSO used; spinal cord injury.

Q0912 Qian,N.S., Liao,Y.H., Feng,Q.X., Tang,Y., Dou,K.F., Tao,K.S. Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat. Molecular Pain 2011; 7(-;-):U1-U11. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, mismatch; CSF/CNS (intrathecal); Rat; 2001; 1 week; Negative cntrols received mp w/ mismatch oligodeoxynucleotide; animal info (male, Sprague-Dawley, 250-300 g, laminectomy); antisense (TLR3); PE-10 catheter used.

Q0845 Shen,C.H., Tsai,R.Y., Shih,M.S., Lin,S.L., Tai,Y.H., Chien,C.C., Wong,C.S. Etanercept Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in Morphine-Tolerant Rats. Anesthesia and Analgesia 2011; 112(-2-):454-459. >>> Morphine; CSF/CNS (intrathecal); Rat; 2001; 5 days; Controls received mp w/ saline; animal info (male, Wistar, 300-350 g); two intrathecal catheters inserted caudally into the lumbar enlargement of the spinal cord; catheter was made by sealing PE-10 to silastic tubing with epoxy resin and silicone rubber; dead space of the catheter was about 8 ul; pain.

Q0685 Toda,S., Sakai,A., Ikeda,Y., Sakamoto,A., Suzuki,H. A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain. Molecular Pain 2011; 7(-;-):U1-U11. >>> Nerve growth factor, beta, recomb., rat; Saline; albumin, rat, serum; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 220-300 g); chronic constrictive injury (CCI).

Q0846 Yamdeu,R.S., Shaqura,M., Mousa,S.A., Schaefer,M., Droese,J. p38 Mitogen-activated Protein Kinase Activation by Nerve Growth Factor in Primary Sensory Neurons Upregulatesμ-Opioid Receptors to Enhance Opioid Responsiveness Toward Better Pain Control. Anesthesiology 2011; 114(-1-):150-161. >>> Fentanyl propionanilide; buprenorphine hydrochloride; Saline, isotonic; CSF/CNS (intrathecal); Rat; 96 hours; Controls received mp w/ vehicle; animal info (male Wistar, 200-250 g); pain.

Q0395 Adachi,K., Shimizu,K., Hu,J.W., Suzuki,I., Sakagami,H., Koshikawa,N., Sessle,B.J., Shinoda,M., Miyamoto,M., Honda,K., Iwata,K. Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. Molecular Pain 2010; 6(-;-):U1-U11. >>> PD 98059; DMSO; CSF/CNS (intrathecal); Rat; 1 week; Animal info (male, Sprague Dawley, adult, 300-360 g); enzyme inhibitor (mitogen-activated extracellular signal-regulated kinase, MEK); 10% DMSO used.

P9904 Boettger,M.K., Weber,K., Grossmann,D., Gajda,M., Bauer,R., Baer,K.J., Schulz,S., Voss,A., Geis,C., Braeuer,R., Schaible,H.G. Spinal Tumor Necrosis Factor alpha-Neutralization Reduces Peripheral Inflammation and Hyperalgesia and Suppresses Autonomic Responses in Experimental Arthritis A Role for Spinal Tumor Necrosis Factor alpha-During Induction and Maintenance of Peripheral Inflammation. Arthritis and Rheumatism 2010; 62(-5-):1308-1318. >>> Etanercept; CSF/CNS (intrathecal); Rat; 2ML4; 3, 21 days; Controls received mp w/vehicle: animal info (Lewis, 6-8 wks, 160-180 g); ALZET intrathecal catheter used; schematic drawing with ALZET pump and catheter.

Q0005 Boettger,M.K., Weber,K., Gajda,M., Braeuer,R., Schaible,H.G. Spinally applied ketamine or morphine attenuate peripheral inflammation and hyperalgesia in acute and chronic phases of experimental arthritis. BRAIN BEHAVIOR AND IMMUNITY 2010; 24(-3-):474-485. >>> Ketamine, Morphine; Saline; CSF/CNS (intrathecal); Rat; 2ML4; 21 days; Controls received mp w/ vehicle; tolerance; ALZET brain infusion kit used; half-life pg 477 (2.5 hrs in CSF (ketamine); 2.1 hrs (morphine)); animal info (Female, Lewis, 6-8 wks old, 160-180 g); dorsal laminectomy; behavioral testing (pain related behavior).

Q0101 Calvo,M., Zhu,N., Tsantoulas,C., Ma,Z.Z., Grist,J., Loeb,J.A., Bennett,D.L.H. Neuregulin-ErbB Signaling Promotes Microglial Proliferation and Chemotaxis Contributing to Microgliosis and Pain after Peripheral Nerve Injury. Journal of Neuroscience 2010; 30(-15-):5437-5450. >>> PD168393; DMSO; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; animal info (male, Wistar, adult); 5% DMSO used.

Q0155 Cheng,H.T., Dauch,J.R., Oh,S.S., Hayes,J.M., Hong,Y., Feldman,E.L. p38 mediates mechanical allodynia in a mouse model of type 2 diabetes. Molecular Pain 2010; 6(-;-):U1-U14. >>> SB203580; CSF, artificial; DMSO; CSF/CNS (intrathecal); Mice; 1007D; 1 week; Animal info (db+, db/db, 8 wks old); 10% DMSO used; diabetes; PE cannula used to target the L5 region.

Q0009 Cirillo,G., Cavaliere,C., Bianco,M.R., De Simone,A., Colangelo,A.M., Sellitti,S., Alberghina,L., Papa,M. Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain. Cellular and Molecular Neurobiology 2010; 30(-1-):51-62. >>> Nerve growth factor, b-, recomb. rat; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (adult, male, Sprague-Dawley, 250-300 g); SCI; spinal cord injury; behavioral testing (thermal nociceptive testing, mechanical allodynia).

Q0062 Fossat,P., Dobremez,E., Bouali-Benazzouz,R., Favereaux,A., Bertrand,S.S., Kilk,K., Leger,C., Cazalets,J.R., Langel,U., Landry,M., Nagy,F. Knockdown of L Calcium Channel Subtypes: Differential Effects in Neuropathic Pain. Journal of Neuroscience 2010; 30(-3-):1073-1085. >>> Nicardipine; CSF/CNS (intrathecal); Rat; 1007D; 5 days; Animal info (adult, Wistar, 250-300 g.); PE-10 catheter used.

Q0146 Gao,Y.J., Xu,Z.Z., Liu,Y.C., Wen,Y.R., Decosterd,I., Ji,R.R. The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. Pain 2010; 148(-2-):309-319. >>> D-JNK-1; SP 600125; Saline; DMSO; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 220-260 g., 20-30 g, JNK1 -/-, JNK2 -/-); PE-10 catheter used; 10% DMSO used; "We cannot exclude the possibility that the peptide inhibitor is degraded over time at the body temperature" pg 314.

Q0074 Geremia,N.M., Pettersson,L.M.E., Hasmatali,J.C., Hryciw,T., Danielsen,N., Schreyer,D.J., Verge,V.M.K. Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Experimental Neurology 2010; 223(-1-):128-142. >>> Brain-derived neurotrophic factor, anti-, sheep; immunoglobulin G, sheep; CSF/CNS (intrathecal); Rat; 2001; 3 days; Controls received mp w/ control IgG; post op. care (buprenorphine); animal info (male, Wistar, adult, 300-500 g.); sciatic nerve transection.

Q0014 Gonzenbach,R.R., Gasser,P., Zoerner,B., Hochreutener,E., Dietz,V., Schwab,M.E. Nogo-A Antibodies and Training Reduce Muscle Spasms in Spinal Cord-Injured Rats. Annals of Neurology 2010; 68(-1-):48-57. >>> Antibody, mouse anti-nogo-A (11C7-10); antibody, mouse anti-nogo-A (7B12-10); immunoglobulin G; PBS; CSF/CNS (intrathecal, injury site); Rat; 2ML2; 2 weeks; Controls received mp w/IgG; animal info (female, Lewis, 180-300 g, SCI); behavioral testing (locomotor assessment).

Q0061 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Schut,D., Fehlings,M.G. Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord. Journal of Neuroscience 2010; 30(-5-):1657-1676. >>> Chondriotinase ABC; epidermal growth factor; fibroblast growth factor; platelet-derived growth factor; Penicillinase; saline; albumin, rat serum; CSF, artificial; gentamicin; BSA; CSF/CNS (intrathecal, subarachnoid space); Rat; 1007D; 7 days; Controls received mp w/ vehicle; animal info (female, Wistar, 250 g.); ALZET intrathecal catheter used (0007741).

Q0137 King,V.R., Hewazy,D., Alovskaya,A., Phillips,J.B., Brown,R.A., Priestley,J.V. THE NEUROPROTECTIVE EFFECTS OF FIBRONECTIN MATS AND FIBRONECTIN PEPTIDES FOLLOWING SPINAL CORD INJURY IN THE RAT. Neuroscience 2010; 168(-2-):523-530. >>> Fibronectin mat solution; peptide, fibronectin-derived synthetic; Saline; CSF/CNS (intrathecal); Rat; 1007D; 1, 3, 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, adult, laminectomized); silastic tubing used; spinal cord injury.

P9908 Lin,S.L., Tsai,R.Y., Tai,Y.H., Cherng,C.H., Wu,C.T., Yeh,C.C., Wong,C.S. Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords. Behavioural Brain Research 2010; 207(-1-):30-36. >>> Naloxone; morphine; CSF/CNS (intrathecal); Rat; 5 days; Controls received mp w/saline; animal info (male, Wistar, 350-400 g); pumps contained morphine alone or morphine and naloxone; two intrathecal catheters implanted.

Q0250 Ma,T.C., Campana,A., Lange,P.S., Lee,H.H., Banerjee,K., Bryson,J.B., Mahishi,L., Alam,S., Giger,R.J., Barnes,S., Morris,SM Jr, Willis,D.E., Twiss,J.L., Filbin,M.T., Ratan,R.R. A Large-Scale Chemical Screen for Regulators of the Arginase 1 Promoter Identifies the Soy Isoflavone Daidzein as a Clinically Approved Small Molecule That Can Promote Neuronal Protection or Regeneration via a cAMP-Independent Pathway. Journal of Neuroscience 2010; 30(-2-):739-748. >>> Daidzein; DMSO; CSF/CNS (intrathecal); SC; Rat; 1007D; 2 weeks; 24 hours; Controls received mp w/ vehicle; animal info (Fisher, 28-30 days old; 250-300g); dose-response (fig. 4); wound clips used; optic nerve crush injury and regeneration model; comparison of SC mp vs IT mp to determine if agent is able to cross BBB.

P9954 Mountney,A., Zahner,M.R., Lorenzini,I., Oudega,M., Schramm,L.P., Schnaar,R.L. Sialidase enhances recovery from spinal cord contusion injury. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010; 107(-25-):11561-11566. >>> Sialidase; Saline; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 12 days; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 230-250 g.); spinal cord injury.

R0271 Nesic,O., Guest,J.D., Zivadinovic,D., Narayana,P.A., Herrera,J.J., Grill,R.J., Mokkapati,V.U.L., Gelman,B.B., Lee,J. AQUAPORINS IN SPINAL CORD INJURY: THE JANUS FACE OF AQUAPORIN 4. Neuroscience 2010; 168(-4-):1019-1035. >>> Bumetanide; interleukin-1 receptor antagonist; CSF/CNS (intrathecal); Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; spinal cord injury.

Q0836 Obata,H., Sakurazawa,S., Kimura,M., Saito,S. Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats. Brain Research 2010; 1363(-;-):72-80. >>> Propentofylline; CSF/CNS (intrathecal); Rat; 7 days; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 160-180 g); behavioral testing (paw withdrawal testing); neuropathic pain.

Q0178 Obata,K., Katsura,H., Mizushima,T., Yamanaka,H., Kobayashi,K., Dai,Y., Fukuoka,T., Tokunaga,A., Tominaga,M., Noguchi,K. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury (vol 115, pg 2393, 2005). Journal of Clinical Investigation 2010; 120(-1-):394-394. >>> SB203580; antibody, anti-NGF; oligodeoxynucleotide, antisense; oligodeoxynucleotide, missense; oligodeoxynucleotide, FITC-, antisense; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ missense oligo; animal info (male, Sprague-Dawley, 200-250 g, SNL); antisense (TRPA1); enzyme inhibitor (p38 MAP kinase); 50% DMSO; behavioral testing (basal pain hypersensitivity, paw withdrawal latency, mechanical withdrawal threshold).

P9949 Okubo,M., Yamanaka,H., Kobayashi,K., Noguchi,K. Leukotriene Synthases and the Receptors Induced by Peripheral Nerve Injury in the Spinal Cord Contribute to the Generation of Neuropathic Pain. Glia 2010; 58(-5-):599-610. >>> AA-861; U-75302; SB203580; pranlukast; U0126; Ethanol; saline; DMSO; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; ; Controls received mp w/ saline; enzyme inhibitor (5-lipoxygenase); animal info (male, Sprague Dawley, 200-250 g); 0.02-0.2% ethanol used; 50% DMSO used; spinal nerve injury; behavioral testing (mechanical allodynia).

Q0917 Oshiro,M., Hefferan,M.P., Kakinohana,O., Lukacova,N., Sugahara,K., Yaksh,T.L., Marsala,M. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. British Journal of Pharmacology 2010; 161(-5-):976-985. >>> Baclofen; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ saline; animal info (male, Sprague Dawley, 300-350 g); PE-5 tubing connected to PE-60 tubing; one group received double PE-5 catheter.

P9989 Qi,X.A., Du,Y., Wu,W.T., Yip,H.K. Bone morphogenetic proteins mediate cellular response and, together with Noggin, regulate astrocyte differentiation after spinal cord injury. Experimental Neurology 2010; 221(-2-):353-366. >>> Noggin, recomb. mouse; PBS; CSF/CNS (intrathecal); Mice; 1007D; 1 week; Controls received mp w/ vehicle; animal info (female, adult, C57BL/6n, 6-8 wks old); silastic tubing used for the IT cannulation.

Q0421 Rivat,C., Becker,C., Blugeot,A., Zeau,B., Mauborgne,A., Pohl,M., Benoliel,J.J. Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia. Pain 2010; 150(-2-):358-368. >>> CI-988; chlordiazepoxide; aspirin; DMSO; saline; SC; CSF/CNS (intrathecal); Rat; 2ML1; 2001; 2002; 14 days; Controls received mp w/ vehicle; animal info (Male, Sprague-Dawley, 300-325 g, 8 wks old; ALZET intrathecal catheter used (0007740); behavioral testing (elevated plus-maze).

Q0147 Shibasaki,M., Sasaki,M., Miura,M., Mizukoshi,K., Ueno,H., Hashimoto,S., Tanaka,Y., Amaya,F. Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury. Pain 2010; 149(-3-):514-521. >>> HMGB-1, anti; CSF/CNS (intrathecal); Rat; 7 days; Animal info (male, Sprague Dawley, 200-220 g.); PE-10 catheter used.

Q0341 Verpelli,C., Bertani,G., Cea,V., Patti,M., Bikfalvi,A., Bello,L., Sala,C. Anti-Angiogenic Therapy Induces Integrin-Linked Kinase 1 Up-Regulation in a Mouse Model of Glioblastoma. PLoS One 2010; 5(-10-):U70-U81. >>> PF4-DLR; RNA, small interfering; PBS; SC; CSF/CNS (intrathecal); Mice (nude); 2004; 10, 20 days; Controls received mp w/ vehicle; animal info (6 wks old, nude); peptides; ILK1-siRNA.

Q0415 Wijnvoord,N., Albuquerque,B., Haeussler,A., Myrczek,T., Popp,L., Tegeder,I. Inter-strain differences of serotonergic inhibitory pain control in inbred mice. Molecular Pain 2010; 6(-;-):U1-U11. >>> pCPA; Ringer's solution; CSF/CNS (intrathecal); Mice; 2002; 2 weeks; Controls received mp w/ vehicle; animal info (Male C57BL/6J, 129 Sv, DBA/2J, and BALB/c); enzyme inhibitor (tryptophan hydroxylases); pCPA also known as 4-Chloro-DL-phenylalanine methyl ester hydrochloride; polytetrafluoroethylene tube connected to silicon tube connected to pump; correct catheter placement verified by checking catheter positioning at the end of the treatment period by microscopic inspection.

Q0195 Willi,R., Weinmann,O., Winter,C., Klein,J., Sohr,R., Schnell,L., Yee,B.K., Feldon,J., Schwab,M.E. Constitutive Genetic Deletion of the Growth Regulator Nogo-A Induces Schizophrenia-Related Endophenotypes. Journal of Neuroscience 2010; 30(-2-):556-567. >>> Antibody, monoclonal, anti-nogo-A; antibody, monoclonal IgG; PBS; CSF/CNS (intrathecal); Mice; 1002; 2 weeks; Controls received mp w/ IgG or no mp; brain tissue distribution; animal info (C57BL/6J, 2-4 months old); behavioral testing (elevated plus maze, open field exploration, prepulse inhibition, active avoidance learning, discrimination reversal learning, latent inhibition, social interaction and social novelty, amphetamine-induced locomotor activity); 32 G catheter inserted into the L2 region and advanced to the T10 region.

Q0559 Brades,S., Svensson,C.I., Steinauer,J., Pothoulakis,C., Yaksh,T.L., Mayer,E.A. Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress. Gastroenterology 2009; 136(-4-):1339-1348. >>> SB203580; minocycline; Saline; CSF/CNS (intrathecal); Rat; 2002; 10 days; Controls received mp w/ vehicle; animal info (adult, male, Wistar, 250-275 g); enzyme inhibitor (MAPK, mitogen-activated protein kinase); PE5 connected to PE10 tubing used; catheter position verified postmortem.

Q0266 Byrnes,K.R., Stoica,B., Riccio,A., Pajoohesh-Ganji,A., Loane,D.J., Faden,A.I. Activation of Metabotropic Glutamate Receptor 5 Improves Recovery after Spinal Cord Injury in Rodents. Annals of Neurology 2009; 66(-1-):63-74. >>> Hydroxyphenylglycine, (RS)-2-chloro-5; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male, Sprague-Dawley, 275-325 g); functionality of mp verified by pump weight; spinal cord injury; 10% DMSO used; compound also known as CHPG; CHPG is a selective mGluR5 agonist.

Q0438 Chan,S.H.H., Wu,C.A., Wu,K.L.H., Ho,Y.H., Chang,A.Y.W., Chan,J.Y.H. Transcriptional Upregulation of Mitochondrial Uncoupling Protein 2 Protects Against Oxidative Stress-Associated Neurogenic Hypertension. Circulation Research 2009; 105(-9-):886-U145. >>> Rosiglitazone; oligonucleotide, antisense; angiotensin II; CSF, artificial; DMSO; CSF/CNS; CSF/CNS (intrathecal, cisterna magna); 2001; 7 days; Controls received mp w/ vehicle; animal info (adult, male Sprague-Dawley, 10-11 wks old); antisense (UCP2); peptides; 0.5% DMSO used.

P9484 Chen,Y.H., Oatway,M.A., Weaver,L.C. Blockade of the 5-HT3 Receptor for Days Causes Sustained Relief From Mechanical Allodynia Following Spinal Cord Injury. Journal of Neuroscience Research 2009; 87(-2-):418-424. >>> Ondansetron; Saline; IV (jugular); CSF/CNS (intrathecal); Rat; 1003D; 2001; 7 days, 72 hours; Controls received mp w/ vehicle; half life (p. 423) ~45 min; animal info (male, Wistar, 250-300 g.); pumps primed; spinal cord injury; ondansetron is a 5-HT3 receptor antagonist; Zofran.

Q0663 Deng,K.W., He,H.F., Qiu,J., Lorber,B., Bryson,J.B., Filbin,M.T. Increased Synthesis of Spermidine as a Result of Upregulation of Arginase I Promotes Axonal Regeneration in Culture and In Vivo. Journal of Neuroscience 2009; 29(-30-):9545-9552. >>> Putrescine; spermidine; difluoromethylornithine; CSF/CNS (intrathecal); Rat; 1007D; 1-7 days; Controls received mp w/ vehicle; animal info (postnatal day 20-22).

P9873 Echeverry,S., Shi,X.Q., Haw,A., Liu,H., Zhang,Z., Zhang,J. Transforming growth factor-beta-1 impairs neuropathic pain through pleiotropic effects. Molecular Pain 2009; 5(-;-):U1-U18. >>> Transforming growth factor-1, beta; CSF/CNS (intrathecal); Rat; 1007D; 2002; 7, 14 days; Animal info (male, Sprague Dawley, 250-275 g); incorrectly stated pump model as 2002D.

P9802 Fouad,K., Ghosh,M., Vavrek,R., Tse,A.D., Pearse,D.D. Dose and Chemical Modification Considerations for Continuous Cyclic AMP Analog Delivery to the Injured CNS. Journal of Neurotrauma 2009; 26(-5-):733-740. >>> Dibutyryl cAMP; cAMP, 8-bromo; Saline; CSF/CNS (intrathecal); CSF/CNS (motor cortex); Rat; 2002; 2, 4 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit used; post op. care (Buprenorphine); animal info (adult, female, Lewis, 180-200 g.); spinal cord injury.

Q0287 Furuya,T., Hashimoto,M., Koda,M., Okawa,A., Murata,A., Takahashi,K., Yamashita,T., Yamazaki,M. Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation. Brain Research 2009; 1295(-;-):192-202. >>> Fasudil; Saline; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 8-10 wks old, 174-236 g); post op. care (Bacitramin); spinal cord injury.

Q0744 Kohta,M., Kohmura,E., Yamashita,T. Inhibition of TGF-beta 1 promotes functional recovery after spinal cord injury. NEUROSCIENCE RESEARCH 2009; 65(-4-):393-401. >>> Antibody, anti-TGF beta-1; CSF/CNS (intrathecal, spinal cord); Rat; 2002; 2 weeks; Controls received mp w/ control rabbit IgG; animal info (female, Sprague-Dawley, 200-250 g, laminectomy); silastic tubing connected to the pump; spinal cord injury.

Q0270 Kondo,T., Obata,K., Miyoshi,K., Sakurai,J., Tanaka,J., Miwa,H., Noguchi,K. Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats. Gut 2009; 58(-10-):1342-1352. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, mismatch; Saline, normal; CSF/CNS (intrathecal); Rat; 1003D; ; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 190-260 g.); antisense (TRPA1); incorrectly listed Model 2003 pumps.

P9706 Maier,I.C., Ichiyama,R.M., Courtine,G., Schnell,L., Lavrov,I., Edgerton,V.R., Schwab,M.E. Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury. Brain 2009; 132(-;-):1426-1440. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/mouse immunoglobulin G; animal info (adult, male, Sprague Dawley, 200-250 g.).

R0263 Merrill,J.E. In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination. Neuropsychopharmacology 2009; 34(-1-):55-73. >>> Antibody, anti-LINGO-1; Prolactin; CSF/CNS; intrathecal; SC; IP; Mice; rat; 2-3 weeks; Animal info (MOG-induced Experimental Autoimmune Encephalomyelitis).

P9602 Miyashita,T., Koda,M., Kitajo,K., Yamazaki,M., Takahashi,K., Kikuchi,A., Yamashita,T. Wnt-Ryk Signaling Mediates Axon Growth Inhibition and Limits Functional Recovery after Spinal Cord Injury. Journal of Neurotrauma 2009; 26(-7-):955-964. >>> Immunoglobulin G, rabbit; antibody, anti Ryk; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp/saline; animal info (Sprague Dawley, 200-250g, female); spinal cord injury; SCI.

Q0923 Okada-Ogawa,A., Suzuki,I., Sessle,B.J., Chiang,C.Y., Salter,M.W., Dostrovsky,J.O., Tsuboi,Y., Kondo,M., Kitagawa,J., Kobayashi,A., Noma,N., Imamura,Y., Iwata,K. Astroglia in Medullary Dorsal Horn (Trigeminal Spinal Subnucleus Caudalis) Are Involved in Trigeminal Neuropathic Pain Mechanisms. Journal of Neuroscience 2009; 29(-36-):11161-11171. >>> Sodium fluoroacetate; CSF/CNS (intrathecal, pia mater); Rat; 2001; ; Controls received mp w/ isotonic saline; animal info (male, adult, Sprague Dawley, 280-380 g); enzyme inhibitor (astroglial aconitase); behavioral testing (escape threshold; soft microsilicon tube (0.8 mm in diameter) used.

P9810 Romo,L.B., Santa-Cruz,L.D., Zepeda,A., Tapia,R. Chronic elevation of extracellular glutamate due to transport blockade is innocuous for spinal motoneurons in vivo. NEUROCHEMISTRY INTERNATIONAL 2009; 54(-3-4-):186-191. >>> PDC; TBOA; CSF/CNS (intrathecal); Rat; 2004; ; Controls received mp w/ Ringer Krebs medium; good methods pg 187; post op. care (penicillin, IM); animal info (adult, male, Wistar, 290-310 g.); PDC also known as L-2,4-trans-pyrrolidinedicarboxylate is a non-selective glutamate transporter blocker; TBOA.

P9757 Tsujimura,T., Kondo,M., Kitagawa,J., Tsuboi,Y., Saito,K., Tohara,H., Ueda,K., Sessle,B.J., Iwata,K. Involvement of ERK phosphorylation in brainstem neurons in modulation of swallowing reflex in rats. JOURNAL OF PHYSIOLOGY-LONDON 2009; 587(-4-):805-817. >>> PD 98059; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; ; Controls received mp w/vehicle; animal info (Sprague Dawley, male, 250-350 g); 10% DMSO used.

Q0261 Welin,D., Novikova,L.N., Wiberg,M., Kellerth,J.O., Novikov,L.N. Effects of N-acetyl-cysteine on the survival and regeneration of sural sensory neurons in adult rats. Brain Research 2009; 1287(-;-):58-66. >>> Cysteine, n-acetyl; CSF/CNS (intrathecal, subarachnoid space); Rat; 2002; 8 weeks; Animal info (adult, 10-12 wks old, female); long-term study; pumps replaced every 14 days; PE60 tubing used.

P9659 Wilson-Gerwing,T.D., Johnston,J.M., Verge,V.M.K. p75 Neurotrophin Receptor Is Implicated in the Ability of Neurotrophin-3 to Negatively Modulate Activated ERK1/2 Signaling in TrkA-Expressing Adult Sensory Neurons. Journal of Comparative Neurology 2009; 516(-1-):49-58. >>> Neurotrophin 3; oligonucleotides, antisense; oligonucleotides, sense; PBS; Streptomycin; albumin, rat serum; penicillin; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/vehicle; functionality of mp verified by flurorescence; antisense (P75); animal info (young male, wistar, 250-300.

Q0288 Wong,C.S., Wu,G.J., Chen,W.F., Jean,Y.H., Hung,C.H., Lin,C.S., Huang,S.Y., Wen,Z.H. N-Methyl-D-aspartate receptor antagonist D-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters. Brain Research Bulletin 2009; 80(-1-2-):69-74. >>> AP5, d-; CSF/CNS (intrathecal); Rat; 2001; 6 days; Controls received mp w/ saline; animal info (Male, Wistar, 400-420 g); two intrathecal catheters inserted; behavioral testing (tail flick latency).

P9539 Xanthos,D.N., Kumar,N., Theodorsson,E., Coderre,T.J. The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation. Neuropharmacology 2009; 56(-3-):684-691. >>> Nerve growth factor, beta; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Long Evans, hooded).

Q0260 Zulauf,L., Coste,O., Marian,C., Moeser,C., Brenneis,C., Niederberger,E. Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception. Biochemical and Biophysical Research Communications 2009; 390(-4-):1408-1413. >>> Y-27632; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; 5 days; Enzyme inhibitor (ROCK); behavioral testing (paw withdrawal latency).

P9324 Averill,S., Inglis,J.J., King,V.R., Thompson,S.W.N., Cafferty,W.B.J., Shortland,P.J., Hunt,S.P., Kidd,B.L., Priestley,J.V. Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis. Neuroscience 2008; 155(-4-):1227-1236. >>> Nerve growth factor, recomb. human; glial-derived neurotrophic factor, recomb. human; leukemia inhibitory factor, recomb. human; Saline; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides, animal info (male, Wistar, 220-400 g.).

P9124 Cao,Y., Shumsky,J.S., Sabol,M.A., Kushner,R.A., Strittmatter,S., Hamers,F.P.T., Lee,D.H.S., Rabacchi,S.A., Murray,M. Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat. NEUROREHABILITATION AND NEURAL REPAIR 2008; 22(-3-):262-278. >>> NEP1-40; DMSO; PBS; CSF/CNS (intrathecal); Rat; 2004; ; Controls received mp w/ vehicle; peptides, animal info (female, Sprague Dawley); 2.5% DMSO used; compound is a Nogo-66 receptor antagonist peptide; good methods (pg. 263).

P9759 Ge,N.N., Brodie,H.A., Tinling,S.P. Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase. OTOLOGY&NEUROTOLOGY 2008; 29(-8-):1061-1067. >>> Superoxide dismutase; CSF, artificial; CSF/CNS (intrathecal); Gerbil; 1002; 14 days; Controls received IM injections of SOD; half-life (p.1065) 40 hours; animal info (8 wks old, male, Mongolian); dental cement used to hold tubing in place; silastic tubing used; image of surgical placement of pumps fig.2., fig. 4.

P9379 Gowing,G., Philips,T., Van Wijmeersch,B., Audet,J.N., Dewil,M., Van den Bosch,L., Billiau,A.D., Robberecht,W., Julien,J.P. Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase. Journal of Neuroscience 2008; 28(-41-):10234-10244. >>> Ganciclovir; CSF/CNS (intrathecal); Mice (transgenic); 2004; 30 days; Controls received mp w/ saline; animal info (CD11b-Tkmt-30-SOD1G93A Tg, 85 days old); neurodegenerative (ALS); IP injection of ganciclovir given 24 hours before and during mp implantation surgery; behavioral testing (hindlimb reflex); "chronic and systemic injection of the nucleoside analog ganciclovir is lethal for CD11b-Tkmut30 transgenic mice, and ganciclovir is not highly diffusable within CNS tissue... To overcome this constraint, we proceeded with direct delivery of ganciclovir to the spinal cord via an osmotic pump connected to a cannula located in the intrathecal space." (p. 10240).

P9409 Hanna-Mitchell,A.T., O'Leary,D., Mobarak,M.S., Ramer,M.S., McMahon,S.B., Priestley,J.V., Kozlova,E.N., Aldskogius,H., Dockery,P., Fraher,J.P. The impact of neurotrophin-3 on the dorsal root transitional zone following injury. SPINAL CORD 2008; 46(-12-):804-810. >>> Neurotrophin-3; CSF/CNS (intrathecal); Rat; 1 week; Controls received no treatment; animal info (Sprague Dawley, dorsal root crush axotomy).

P9411 Hayashida,K.I., Clayton,B.A., Johnson,J.E., Eisenach,J.C. Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain 2008; 136(-3-):348-355. >>> Antibody, polyclonal sheep anti-BDNF; immunoglobulin G, sheep; Saline; CSF/CNS (intrathecal); Rat; 2002; 11 days; Controls received mp w/ IgG; no stress (see pg. 351); animal info (male, Sprague Dawley, 200-250 g., spinal nerve ligation); behavioral testing (withdrawal threshold); "animals tolerated intrathecal infusion of the antibody to BDNF with no change in spontaneous behavior." (p. 351).

P9079 Hurtado,A., Podinin,H., Oudega,M., Grimpe,B. Deoxyribozyme-mediated knockdown of xylosyltransferase-1 mRNA promotes axon growth in the adult rat spinal cord. Brain 2008; 131(-;-):2596-2605. >>> DNAXTas; CSF/CNS (spinal cord, intrathecal); Rat; 1007D; 14 days; Controls received mp w/ control deoxyribozyme or mp w/ saline; pumps replaced after 7 days; post op. care (gentamicin); animal info (female, Sprague Dawley, 200-225 g.); control also known as DNAXTmb; schematic w/ pump on fig. 1; custom cannula used.

P9163 Hutchinson,M.R., Zhang,Y.N., Brown,K., Coats,B.D., Shridhar,M., Sholar,P.W., Patel,S.J., Crysdale,N.Y., Harrison,J.A., Maier,S.F., Rice,K.C., Watkins,L.R. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). European Journal of Neuroscience 2008; 28(-1-):20-29. >>> Naloxone; Saline, sterile; SC; CSF/CNS (intrathecal); Rat; 2001; 4 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 300-375 g.); sciatic nerve injury.

P9331 Kim,D.H., Fitzsimmons,B., Hefferan,M.P., Svensson,C.I., Wancewicz,E., Monia,B.P., Hung,G., Butler,M., Marsala,M., Hua,X.Y., Yaksh,T.L. Inhibition of spinal cytosolic phospholipase A2 expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience 2008; 154(-3-):1077-1087. >>> Oligonucleotide, phosphorothioate antisense; oligonucleotide, phosphorothioate missense; Saline; CSF/CNS (intrathecal); Rat; 2001; 5 days; Controls received mp w/ missense oligo; dose-response (fig. 2); antisense (cPLA2IVA); animal info (male, Holzmann, 300-350 g.); agents specifically known as ISIS 122523 and ISIS 141923; behavioral testing (thermal paw withdrawal test, formalin-induced flinching).

P8909 Liao,Y.J., Safa,P., Chen,Y.R., Sobel,R.A., Boyden,E.S., Tsien,R.W. Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-7-):2705-2710. >>> Immunoglobulin G, rabbit; PBS; CSF/CNS (intrathecal, subarachnoid space); Mice; 1003D; 3 days; Functionality of mp verified w/ Alexa 488-labeled goat anti-rabbit IgG staining of coronal sections through the cerebellum); ALZET brain infusion kit 3 used; post op. care (buprenorphine); animal info (C57BL/6, > 20 g.); neurodegenerative (cerebellar ataxia); "multiple practice surgeries to infuse a low-molecular weight dye Fast Green confirmed consistent delivery of pump" (pg. 2709); behavioral study.

P9377 Miyoshi,K., Obata,K., Kondo,T., Okamura,H., Noguchi,K. Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury. Journal of Neuroscience 2008; 28(-48-):12775-12787. >>> Immunoglobulin G, goat; antibody, anti-interleukin-18; antibody, anti-leukin-18 receptor; interleukin-18 binding protein; RNA, small interfering; PBS; CSF/CNS (intrathecal); Rat; mice; 1003D; 2001; 3, 7 days; Controls received mp w/ vehicle or IgG or negative siRNA; peptides; animal info (male, Sprague Dawley, 200-250 g.; male, C57BL/6 wt, IL-18 -/-, 25-30 g.); siRNA targets TLR4 (toll-like receptor 4) or negative siRNA; behavioral testing (mechanical hypersensitivity, tactile allodynia).

P8820 Muellner,A., Gonzenbach,R.R., Weinmann,O., Schnell,L., Liebscher,T., Schwab,M.E. Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats. European Journal of Neuroscience 2008; 27(-2-):326-333. >>> Antibody, anti-Nogo-A monoclonal 11C7; antibody, anti-Nogo A monoclonal 7B12; Immunoglobulin G, mouse; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/ IgG; post op. care (Baytril); animal info (Lewis, 2 months old, 160-180g. SCI).

P9205 Nakashima,S., Arnold,S.A., Mahoney,E.T., Sithu,S.D., Zhang,Y.P., D'Souza,S.E., Shields,C.B., Hagg,T. Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats. Journal of Neuroscience 2008; 28(-29-):7293-7303. >>> BpV(phen); PBS; CSF/CNS (intrathecal); Rat; 1007D; 7, 28 days; Controls received mp w/ vehicle; dose-response (fig. 2); pumps replaced every 7 days; no stress (see pg. 7297); animal info (female, Sprague Dawley, 180-200 g.); spinal cord injury; behavioral testing (grid walking, mechanical allodynia); bpV(phen) also known as potassium bisperoxo(1,10-phenanthroline) oxovanadate (V); enzyme inhibitor (protein tyrosine phosphatase).

P9209 Ohta,Y., Kamiya,T., Nagai,M., Nagata,T., Morimoto,N., Miyazaki,K., Murakami,T., Kurata,T., Takehisa,Y., Ikeda,Y., Asoh,S., Ohta,S., Abe,K. Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience Research 2008; 86(-13-):3028-3037. >>> TAT-GFP; TAT-Bcl-XL; CSF, artificial; CSF/CNS (intrathecal); Mice; mice (transgenic); 2001; 2004; 7, 28 days; Controls received mp w/ vehicle; stability verified by antiapoptotic effect at 7, 14, and 28 days at 37 degree Celsius (p. 3031); peptides; animal info (male, B6SJL, wt, G93A SOD1 Tg, 91 days old); neurodegenerative (ALS); behavioral testing (Rotarod test, wheel running test); "intrathecal infusion of TAT-infused proteins using an osmotic minipump is a better method of delivering therapeutic proteins into the spinal cord." (p. 3035).

P9442 Scholz,J., Abele,A., Marian,C., Haeussler,A., Herbert,T.A., Woolf,C.J., Tegeder,I. Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain 2008; 138(-1-):130-142. >>> Methotrexate; dexamethasone; CSF, artificial; PBS; CSF/CNS (intrathecal); Rat; 7, 14 days; Controls received mp w/ vehicle; dose-response (fig. 7); comparison of IP injections vs. mp; enzyme inhibitor (dihydrofolate reductase); animal info (male, Sprague Dawley, 160-200 g., SNI); behavioral testing (paw withdrawal, mechanical allodynia, cold allodynia); "sustained intrathecal treatment may therefore suppress microglial activation much more efficiently than intermittent high-dose bolus injections." (p. 140).

P9448 Soril,L.J.J., Ramer,L.M., McPhail,L.T., Kaan,T.K.Y., Ramer,M.S. Spinal brain-derived neurotrophic factor governs neuroplasticity and recovery from cold-hypersensitivity following dorsal rhizotomy. Pain 2008; 138(-1-):98-110. >>> Immunoglobulin G, human; TrkB-Fc; PBS; CSF/CNS (intrathecal); Rat; 2001; 2002; 10, 20 days; Controls received mp w/ vehicle of IgG; pumps replaced after 15 days; animal info (male, Sprague Dawley, 200-250 g., dorsal root injury); behavioral testing (cold allodynia, plantar radiant heat test for thermal allodynia).

P9075 Tai,Y.H., Tsai,R.Y., Wang,Y.H., Cherng,C.H., Tao,P.L., Liu,T.M., Wong,C.S. Amitriptyline induces nuclear transcription factor-kappa B-dependent glutamate transporter upregulation in chronic morphine-infused rats. Neuroscience 2008; 153(-3-):823-831. >>> Morphine; amitriptyline; CSF/CNS (intrathecal); Rat; 2001; ; Controls received mp w/ saline; animal info (male, Wistar, 350-400 g.); intrathecal catheter constructed using polyethylene (0.008 in ID, 0.014 in OD) and silastic tube; behavioral testing (antinociception assay, hot water immersion, tail flick latency).

P8873 Terayama,R., Omura,S., Fujisawa,N., Yamaai,T., Ichikawa,H., Sugimoto,T. Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury. Neuroscience 2008; 153(-4-):1245-1255. >>> SB203580; Saline; CSF/CNS (intrathecal, cisterna magna); Rat; 2002; 14 days; Controls received mp w/ vehicle; enzyme inhibitor (p38 MAP kinase); animal info (male, Sprague Dawley, 250-300g., spinal cord injury); PE10 tubing used; pump infusion schematic pg. 1246, Fig. 1.

P8852 Wang,H.Y., Ghosh,A., Baigude,H., Yang,C.S., Qiu,L.H., Xia,X.G., Zhou,H.X., Rana,T.M., Xu,Z.S. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. Journal of Biological Chemistry 2008; 283(-23-):15845-15852. >>> RNA, small interfering, modified; RNA, small interfering; PBS; CSF/CNS (intrathecal, subarachnoid space); Mice (transgenic); 1007D; 2004; 7, 28 days; 72 hours; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (Fig. 3); no stress (see pg. 15846, 15849); stability verified by 28 days in vivo (see Fig. 2); half-life (p. 15846) "short"; gene therapy; brain tissue distribution; animal info (SOD1G93A Tg); neurodegenerative (ALS); mp + catheter positioning confirmed; Target (SOD1); "when infused at disease onset at the therapeutic dose for 4 weeks, this siRNA slows disease progression without detectable adverse effects." The catheter was implanted between the L5 and L6 vertebra and connected to a primed Alzet osmotic pump with the PE50 tube. The catheter was stitched to the surface muscle, and the Alzet osmotic pumps were placed under the skin on the back of the mouse..

P9090 Wannier-Morino,P., Schmidlin,E., Freund,P., Belhaj-Saif,A., Bloch,J., Mir,A., Schwab,M.E., Rouiller,E.M., Wannier,T. Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A. Brain Research 2008; 1217(-;-):96-109. >>> Immunoglobulin G, monoclonal, mouse; antibody, anti-Nogo-A monoclonal, human; anitbody, anti-Nogo-A monoclonal, mouse; CSF/CNS (intrathecal); Monkey; 2ML2; ; Control animals received mp w/ control antibodies; animal info (macaque, 3-8 years old); pumps replaced every 2 weeks; polyethylene tubing used; spinal cord injury.

P8755 Wen,Z.H., Wu,G.J., Hsu,L.C., Chen,W.F., Chen,J.Y., Shui,H.A., Chou,A.K., Wong,C.S. N-Methyl-D-aspartate receptor antagonist MK-801 attenuates morphine tolerance and associated glial fibrillary acid protein up-regulation: a proteomic approach. Acta Anaesthesiologica Scandinavica 2008; 52(-4-):499-508. >>> Morphine; MK-801; CSF/CNS (intrathecal); Rat; 2001; 5 days; Controls received mp w/ saline; tolerance; animal info (male, Wistar, 350-375g); NMDA receptor antagonist.

P9186 White,R.E., Yin,F.Q., Jakeman,L.B. TGF-alpha increases astrocyte invasion and promotes axonal growth into the lesion following spinal cord injury in mice. Experimental Neurology 2008; 214(-1-):10-24. >>> Transforming growth factor-alpha; Serum, mouse; PBS; CSF/CNS (intrathecal); Mice; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; post op. care (Baytril); animal info (female, adult, C57BL/6, 10 wks old, 17-20 g.); spinal cord injury; pumps were primed in saline at 37 degree Celsius for 24 hours; pumps were weighed before and after filling; good methods; PE-50 used for catheter.

P9183 Wilson-Gerwing,T.D., Stucky,C.L., McComb,G.W., Verge,V.M.K. Neurotrophin-3 significantly reduces sodium channel expression linked to neuropathic pain states. Experimental Neurology 2008; 213(-2-):303-314. >>> NT-3; PBS; albumin, serum; CSF/CNS (intrathecal); Rat; 2001; 7 days; Post op. care (buprenorphine); animal info (male, Wistar, young adult, 250-300 g.).

P9468 Yang,J., Li,Y.Q., Zuo,X.L., Zhen,Y.B., Yu,Y.B., Gao,L.J. Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis. Neuroscience Letters 2008; 440(-3-):237-241. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, missense; Saline, nuclease-free; CSF/CNS (intrathecal); Rat; 2001; 3 days; Controls received mp w/ vehicle; antisense (TRPA1); animal info (male, Wistar, 250-300 g.).

P8458 Byrnes,K.R., Stoica,B.A., Fricke,S., Di Giovanni,S., Faden,A.I. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain 2007; 130(--):2977-2992. >>> Flavopiridol; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 275-325g); contusion spinal cord injury; 1% DMSO.

P8374 Chan,C.C.M., Wong,A.K., Liu,J., Steeves,J.D., Tetzlaff,W. ROCK inhibition with Y27632 activates astrocytes and increases their expression of neurite growth-inhibitory chondroitin sulfate proteoglycans. Glia 2007; 55(-4-):369-384. >>> Y-27632; Saline; CSF/CNS (intrathecal); Rat; 1007D; 1 week; Controls received mp w/ vehicle; dose-response (fig. 1); enzyme inhibitor (Rho kinase); animal info (male, Sprague-Dawley, dorsal column transection).

P9065 Dunbar,S.A., Karamian,I., Zhang,H.H. Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat. EUROPEAN JOURNAL OF PAIN 2007; 11(-1-):1-6. >>> Morphine sulfate; naloxone hydrochloride; ketorlac; SC; CSF/CNS (intrathecal); Rat; 2001; 4, 7 days; Controls received mp w/ saline; tolerance; animal info (adult, male, Sprague Dawley, 350 g.).

P8652 Griffin,R.S., Costigan,M., Brenner,G.J., Ma,C.H.E., Scholz,J., Moss,A., Allchorne,A.J., Stahl,G.L., Woolf,C.J. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. Journal of Neuroscience 2007; 27(-32-):8699-8708. >>> Peptide, C5a receptor antagonist; PBS; CSF/CNS (intrathecal); Rat; 2002; 10 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, C6-deficient, SNI); synthetic, cyclic AcF-[OPdChaWR] peptide.

P8908 Ishigaki,A., Aoki,M., Nagai,M., Warita,H., Kato,S., Kato,M., Nakamura,T., Funakoshi,H., Itoyama,Y. Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model. Journal of Neuropathology and Experimental Neurology 2007; 66(-11-):1037-1044. >>> Hepatocyte growth factor, recomb. human; PBS, sulfoxide; CSF/CNS (intrathecal, subarachnoid space); Rat (transgenic); 2002; 2004; 2, 4 weeks; Controls received mp w/ vehicle; dose-response (fig. 2); peptides; animal info (G93A Tg, 100 and 115 days old); neurodegenerative (ALS); "we examined the effects of continuous intrathecal delivery of human recombinant HGF (hrHGF) into Tg rats using implanted infusion pumps for selective and less invasive supply of HGF to the spinal cord." (p.1038).

P8260 Ito,T., Ohtori,S., Inoue,G., Koshi,T., Doya,H., Ozawa,T., Saito,T., Moriya,H., Takahashi,K. Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis. Spine 2007; 32(-2-):159-167. >>> FR167653; Saline; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; dose-response (fig. 7); no stress (see pg. 163); enzyme inhibitor (pg. 38 MAP kinase); animal info (male, Sprague-Dawley, 200-250g., 6 wks old); Lumbar disc herniation model; spinal canal stenosis model; sciatica.

P8694 Ito,T., Ohtori,S., Hata,K., Inoue,G., Moriya,H., Takahashi,K., Yamashita,T. Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. Spine 2007; 32(-19-):2070-2075. >>> Fasudil hydrochloride hydrate; CSF/CNS (intrathecal); Rat; 2002; 14 days; Enzyme inhibitor (Rho-kinase); animal info (6 week, male, Sprague-Dawley, 200-250g); pain; silastic tubing used; neuroprotection.

P8411 Kozai,T., Yamanaka,H., Dai,Y., Obata,K., Kobayashi,K., Mashimo,T., Noguchi,K. Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury. Glia 2007; 55(-6-):595-603. >>> Tissue plasminogen activator inhibitor; Saline; CSF/CNS (intrathecal, subarachnoid space); Rat; 2002; 5,11,15 days; Controls received mp w/ vehicle; dose-response (fig. 5); animal info (male, Sprague-Dawley, 250-300g.); tPA-STOP; Radiculopathy pain model.

P8826 Kyoto,A., Hata,K., Yamashita,T. Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Research 2007; 1186(-;-):74-86. >>> Antibody, anti-RgMa; Immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ control rabbit IgG; animal info (female, Wistar, 200-250g., SCI); repulsive guidance molecule (RGMa) is a myelin-derived neurite outgrowth inhibitor.

P8481 Locatelli,F., Corti,S., Papadimitriou,D., Fortunate,F., Del Bo,R., Donadoni,C., Nizzardo,M., Nardini,M., Salani,S., Ghezzi,S., Strazzer,S., Bresolin,N., Comi,G.P. Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice. Annals of Neurology 2007; 62(-1-):81-92. >>> RNA, small interfering; CSF/CNS (intrathecal); Mice (transgenic); 2004; 4 weeks; Neurodegenerative (Amyotrophic Lateral Sclerosis); siRNA was used to silence the Fas receptor; animal info (C57BL/6, 90 days old); "Our study demonstrated that Fas silencing is able to interfere with motoneuron degeneration…providing new insights into the ALS pathogenesis and suggesting new possible strategies of molecular therapy…of ALS." p.91.

P8638 Mi,S., Hu,B., Hahm,K.M., Luo,Y., Hui,E.S.K., Yuan,Q.J., Wong,W.M., Wang,L., Su,H.X., Chu,T.H., Guo,J.S., Zhang,W.M., So,K.F., Pepinsky,B., Shao,Z.H., Graff,C., Garber,E., Jung,V., Wu,E.X., Wu,W. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Medicine 2007; 13(-10-):1228-1233. >>> Antibody, anti, LINGO-1; CSF/CNS (intrathecal); Rat; 36 days; Controls received mp w/ isotype control antibody; pumps replaced every 2-weeks, anti-LINGO-1 is an IgG1-isotype antibody.

P8400 Mizushima,T., Obata,K., Katsura,H., Sakurai,J., Kobayashi,K., Yamanaka,H., Dai,Y., Fukuoka,T., Mashimo,T., Noguchi,K. Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity. Journal of Pharmacology and Experimental Therapeutics 2007; 321(-1-):28-34. >>> Oligodeoxynucleotide, phosphorothioate antisense; oligodeoxynucleotide, phosphorothioate missense; oligodeoxynucleotide, FITC-labeled; Saline; CSF/CNS (intrathecal, subarachnoid space); Rat; 1003D; 3 days; Controls received mp w/ vehicle; dose-response (fig. 5); antisense (ERK5); brain tissue distribution; animal info (male, Sprague-Dawley, 220-250g.).

P8433 Svensson,C.I., Zattoni,M., Serhan,C.N. Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. Journal of Experimental Medicine 2007; 204(-2-):245-252. >>> Lipoxin A4; lipoxin B4; lipoxin B4, 8,9-acetylenic; CSF/CNS (intrathecal, lumbar); Rat; ; Controls received mp w/ vehicle; comparison of IT injections vs. mp; animal info (male, sprague-dawley, 250-300 grams); "LXA4 was administered via continuous IT infusion that resulted in a prolonged antihyperalgesic effect compared with IT bolus injections." (P. 247).

P8609 Tsai,S.Y., Markus,T.M., Andrews,E.M., Cheatwood,J.L., Emerick,A.J., Mir,A.K., Schwab,M.E., Kartje,G.L. Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke. Experimental Brain Research 2007; 182(-2-):261-266. >>> Antibody, anti-Nogo-A monoclonal; antibody, immunoglobulin G 1, anti-wheat auxin; CSF/CNS (intrathecal, lumbar); Rat; 2ML2; 2 weeks; Controls received mp w/ IgG1 or no treatment; brain tissue distribution; animal info (male, Long-Evans, 300 grams, MCAO); ischemia (cerebral); "anti-Nogo-A immunotherapy delivered through the more accessible intrathecal route is an effective way to restore neurological function following stroke." (p. 265).

P8706 Vavrek,R., Pearse,D.D., Fouad,K. Neuronal populations capable of regeneration following a combined treatment in rats with spinal cord transection. Journal of Neurotrauma 2007; 24(-10-):1667-1673. >>> Saline; CSF/CNS (intrathecal); Rat; 2002; 4 weeks; Animal info (female, Fischer, adult, spinal cord injury); chondroitinase ABC injected into IT catheter every other day for 4 weeks; saline mp used to keep catheters clear between injections.

P8964 Wen,Y.R., Suter,M.R., Kawasaki,Y., Huang,J., Pertin,M., Kohno,T., Berde,C.B., Decosterd,I., Ji,R.R. Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology 2007; 107(-2-):312-321. >>> FR167653; DMSO; CSF/CNS (intrathecal); Rat; 1007D; 5 days; Controls received mp w/ vehicle; enzyme inhibitor (p38 MAP kinase); animal info (male, Sprague Dawley, 240-300 g., SNI); 30% DMSO used; Behavioral testing (hopping response, tactile placing, mechanical stimulation, heat stimulation, mechanical paw withdrawal threshold).

P8037 Wu,G.J., Wen,Z.H., Chen,W.F., Chang,Y.C., Cherng,C.H., Wong,C.S. The effect of dexamethasone on spinal glutamine synthetase and glutamate dehydrogenase expression in morphine-tolerant rats. Anesthesia and Analgesia 2007; 104(-3-):726-730. >>> Morphine; dexamethasone; CSF/CNS (intrathecal); Rat; 2001; 5 days; Animal info (male, Wistar, 350-370 grams).

P7977 Yamanaka,H., Obata,K., Kobayashi,K., Dai,Y., Fukuoka,T., Noguchi,K. Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain. European Journal of Neuroscience 2007; 25(-4-):1097-1111. >>> Immunoglobulin G, non-immune mouse; antibody, anti-L1-CAM; SB203580; Saline; CSF/CNS (intrathecal); Rat; 2001; 2002; ; Animal info (Male, Sprague-Dawley, 200-250 grams); Silascon tubing, 0.64 mm O.D filled with 5.0 ul's of saline; inserted ~ 0.5 cm's into the intrathecal space; enzyme inhibitor (p38 MAP kinase).

P8872 Yamanaka,H., Obata,K., Kobayashi,K., Dai,Y., Fukuoka,T., Noguchi,K. Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain. Neuroscience 2007; 150(-1-):202-211. >>> SU5402; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; 6 days; Controls received mp w/ saline; animal info (male, Sprague Dawley, 200-250g.); 50% DMSO used; SU5402 is a FGFR1 inhibitor.

P8505 Yurovsky,V.V., Gerzanich,V., Ivanova,S., Dong,Y., Tsymbalyuk,O., Simard,J.M. Autocrine TGF-beta1 mediates angiotensin II-Induced proliferative response of cerebral vessels in vivo. American Journal of Hypertension 2007; 20(-9-):950-956. >>> Angiotensin II; oligodeoxynucleotide, antisense; Saline; SC; CSF/CNS (intrathecal, cisterna magna); Rat; 2001; 2004; 4-28 days; Controls received mp w/ vehicle; blood pressure taken; antisense (TGF, beta); cardiovascular; peptides; second pump placed IT to deliver ODN.

P8487 Zhuang,Z.Y., Kawasaki,Y., Tan,P.H., Wen,Y.R., Huang,J., Ji,R.R. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav.Immun. 2007/7; 21(-5-):642-651. >>> Fractalkine; CSF/CNS (intrathecal, lumbar); Rat; ; Pain; animal info (male, Sprague-Dawley, 200-260 g); PE-5 tubing; agent is a chemokine (AKA, CXCL1).

P8747 Zou,W., Guo,Q., Wang,E., Cai,J., Cheng,Z. Intrathecal morphine suppresses immune function in rats with inflammatory-induced pain. Journal of International Medical Research 2007; 35(-5-):626-636. >>> Morphine; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 1 week; Controls received mp w/ vehicle; dose-response (fig. 1); immunology; post op. care (natrium penicillin); animal info (male, Sprague-Dawley, 250-300g).

P7974 Bennett,D.L.H., Boucher,T.J., Michael,G.J., Popat,R.J., Malcangio,M., Averill,S.A., Poulsen,K.T., Priestley,J.V., Shelton,D.L., McMahon,S.B. Artemin has potent neurotrophic actions on injured C-fibres. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 2006; 11(-4-):330-345. >>> Artmenin, recomb. human; HEPES-mannitol buffer; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (adult, male, spinal nerve ligation and axotoma); GDNF family factor.

P7821 Cao,Z.X., Gao,Y., Bryson,J.B., Hou,J.W., Chaudhry,N., Siddiq,M., Martinez,J., Spencer,T., Carmel,J., Hart,R.B., Filbin,M.T. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. Journal of Neuroscience 2006; 26(-20-):5565-5573. >>> Interleukin-6, recomb. rat; Saline; CSF/CNS (intrathecal); Rat; 1002; 2 weeks; 24 hours; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 7); no stress (see pg. 5571); peptides; animal info (female, Long-Evans, pg. 21-pg. 23; bilateral dorsal column lesion, 8wk old); mp primed at least 4 hours at 37 celsius.

P8029 Dijkstra,S., Duis,S., Pans,I.M., Lankhorst,A.J., Hamers,F.P.T., Veldman,H., Baer,P.R., Gispen,W.H., Joosten,E.A.J., Geisert,EE Jr  Experimental Neurology 2006; 202(-1-):57-66. >>> Antibody, anti-CD81; immunoglobulin, G; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Post op. care (fluid therapy, 3.0 ml saline); animal info (adult, female, Wistar, 11 weeks old, 200-240 grams); spinal cord cannulation technique outlined (p. 58); PE tubing used; pump functionality measured incorrectly; x-ray image of pump/cannulation (p. 59); behavioral study.

P8134 Figueroa,J.D., Benton,R.L., Velazquez,I., Torrado,A.I., Ortiz,C.M., Hernandez,C.M., Diaz,J.J., Magnuson,D.S., Whittemore,S.R., Miranda,J.D. Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. Journal of Neuroscience Research 2006; 84(-7-):1438-1451. >>> Oligonucleotide, missense; oligonucleotide, antisense; oligonucleotide, FITC antisense; CSF/CNS (intrathecal); Rat; 2002; 1, 2, 3, 4 weeks; Controls received mp w/ missense oligonucleotide; antinsense (EphA7); brain tissue distribution; cyanoacrylate adhesive; animal info (female, Sprague-Dawley, 200-275g., SCI contusion); mp primed overnight in 37 celsius.

P7814 Hata,K., Fujitani,M., Yasuda,Y., Doya,H., Saito,T., Yamagishi,S., Mueller,B.K., Yamashita,T. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Journal of Cell Biology 2006; 173(-1-):47-58. >>> Antibody, anti-rat RGMA; immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ rabbit IgG; animal info (female, Wistar, 200-250g., spinal cord hemisection); repulsive guidance molecule (RGM).

P8136 Ishii,K., Nakamura,M., Dai,H.N., Finn,T.P., Okano,H., Toyama,Y., Bregman,B.S. Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury. Journal of Neuroscience Research 2006; 84(-8-):1669-1681. >>> Antibody, polyclonal goat anti-CNTF; immunoglobulin-G, goat; CSF/CNS (Intrathecal, subarachnoid space); Rat; 2002; 14 days; Controls received mp w/ IgG; brain tissue distribution; animal info (female, Sprague-Dawley, 250-300g. spinal cord lesioning, NSC transplant).

P7677 Ivanov,A., Gerzanich,V., Ivanova,S., DenHaese,R., Tsymbalyuk,O., Simard,J.M. Adenylate cyclase 5 and Kca1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 570(-1-):73-84. >>> Epidermal growth factor; AG-1478; angiotensin II; iberiotoxin; CSF, artificial; saline; CSF/CNS (intrathecal, cisterna magna); SC; Rat; 2001; 2004; 1,3 days; 4 weeks; Controls received mp w/ aCSF; cardiovascular; peptides; animal info (female, wistar, 275-325 g); angiotensin II disolved in saline and was subcutaneously delivered for 4 weeks using the 2004 model pump; AG-1478 is an EGFR inhibitor.

P7884 Jhamandas,K., Milne,B., Sutak,M., Gouarderes,C., Zajac,J.M., Yang,H.Y.T. Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides. Peptides 2006; 27(-5-):953-963. >>> Morphine sulfate; CSF/CNS (intrathecal); Rat; 2001; 6 days; Comparison of IT injections vs. mp; tolerance; animal info (male, Sprague-Dawley, 250-275g.).

P8112 Ji,B., Li,M., Wu,W.T., Yick,L.W., Lee,X., Shao,Z., Wang,J., So,K.F., Mccoy,J.M., Pepinsky,R.B., Mi,S., Relton,J.K. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. MOLECULAR AND CELLULAR NEUROSCIENCE 2006; 33(-3-):311-320. >>> Immunoglobulin G1, human; LINGO-1-Fc, recomb. human; PBS; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle, or IgG1; replacement therapy (dorsal hemisection); peptides; post op. care (Buprenorphine/Buprenex, Ampicillin); animal info (female, Long Evans, 7 wk old).

P8019 Kaneko,S., Iwanami,A., Nakamura,M., Kishino,A., Kikuchi,K., Shibata,S., Okano,H.J., Ikegami,T., Moriya,A., Konishi,O. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nature Medicine 2006; 12(--):1380-1389. >>> SM-216289; CSF/CNS (intrathecal, spinal cord lesion); Rat; 2004; 4 weeks; Controls received mp w/ PBS; animal info (female, Sprague-Dawley, 200-250 grams, spinal cord transection); neuroscience.

P7808 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Morshead,C.M., Fehlings,M.G. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. Journal of Neuroscience 2006; 26(-13-):3377-3389. >>> Fibroblast growth factor, basic; epidermal growth factor; platelet-derived growth factor-AA; CSF, artificial; gentamycin; BSA; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Peptides; animal info (female, Wistar, 250g., spinal cord injury, neural precursor cells transplantation).

P8969 Katsura,H., Obata,K., Mizushima,T., Yamanaka,H., Kobayashi,K., Dai,Y., Fukuoka,T., Tokunaga,A., Sakagami,M., Noguchi,K. Antisense knock down of TRPA1, but not TRPM8. alleviates cold hyperalgesia after spinal nerve ligation in rats. Experimental Neurology 2006; 200(-1-):112-123. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, mismatch; Saline, normal; CSF/CNS (intrathecal); Rat; 2001; 3, 5, 7days; 6, 12, 24 hours; Controls received mp w/ vehicle; antisense (TRPA1, TRPM8); animal info (male, Sprague Dawley, SNL, 200-250 g.).

P8118 Katsura,H., Obata,K., Mizushima,T., Sakurai,J., Kobayashi,K., Yamanaka,H., Dai,Y., Fukuoka,T., Sakagami,M., Noguchi,K. Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. Journal of Neuroscience 2006; 26(-34-):8680-8690. >>> PP2; PP3; DMSO; saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ normal saline; dose-response (fig.8); enzyme inhibitor (Src-Family tyrosine kinase); animal info (male, Sprague-Dawley, 200-250g., spinal nerve ligation); 50% DMSO.

P7558 Kelleher,M.O., Myles,L.M., Al-Abri,R.K., Glasby,M.A. The use of ciliary neurotrophic factor to promote recovery after peripheral nerve injury by delivering it at the site of the cell body. Acta Neurochirurgica 2006; 148(-1-):55-61. >>> Ciliary neurotrophic factor; CSF/CNS (intrathecal, subarachnoid space); Sheep; 2ML4; 28 days; Controls received mp w/ physiological saline; no stress (see pg. 57); half-life (pg. 59) 3 minutes in serum; peptides; post op. care (cefuroxime); median nerve transected and repaired; "The adverse cytokine-like side-effects associated with systemic administration of CNTF, namely cough, asthenia, nausea, anorexia and weight loss, aphthous stomatitis and fever were not observed in any of our animals". (pg. 57).

P8126 Lin,C.R., Amaya,F., Barrett,L., Wang,H.B., Takada,J., Samad,T.A., Woolf,C.J. Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity. Journal of Pharmacology and Experimental Therapeutics 2006; 319(-3-):1096-1103. >>> RNA, short hairpin; RNA, short hairpin, mismatched; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle, or mismatched shRNA; dose-response (p.1100); antisense (Ep4); brain tissue distribution; toxicology; animal info (male, Sprague-Dawley, 200g., peripheral hind paw inflammation).

P7856 Liu,Y.R., Liu,J., Tetzlaff,W., Paty,D.W., Cynader,M.S. Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis. Free Radical Biology and Medicine 2006; 40(-6-):960-967. >>> CSF, artificial; CSF, artificial; gentamicin; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; ; Immunology; animal info (male, Lewis, 200g., EAE (experimental autoimmune encephalomyelitis)); freshly prepared antioxidant enzymes were delivered intrathecally once daily through the PE tubing via Hamilton syringe on days 13-17, mp then reconnected to keep tube clear; multiple sclerosis model; pump used to maintain catheter patency.

R0251 McKerracher,L., Higuchi,H. Targeting Rho to stimulate repair after spinal cord injury. Journal of Neurotrauma 2006; 23(-3-4-):309-317. >>> C3 transferase; Y-27632; CSF/CNS (intrathecal); Rat; ; Enzyme inhibitor (Rho kinase); review, see p. 313-314, ref. Fournier et al; Ramer et al; spinal cord injury.

P8028 Obata,K., Katsura,H., Sakurai,J., Kobayashi,K., Yamanaka,H., Dai,Y., Fukuoka,T., Noguchi,K. Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury. Journal of Neuroscience 2006; 26(-46-):11974-11986. >>> Antibody, anti-NGF; antibody, anti-P75NTR; K252a; DMSO; saline; CSF/CNS (intrathecal, lumbar); Rat; 2001; ; Controls received mp w/ saline; animal info (male, Sprague-Dawley, 200-250 grams); nerve injury; silastic tubing used; K252a in 50% DMSO; behavioral testing.

P8024 Ohta,Y., Nagai,M., Nagata,T., Murakarni,T., Nagano,I., Narai,H., Kurata,T., Shiote,M., Shoji,M., Abe,K. Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene. Journal of Neuroscience Research 2006; 84(-5-):980-992. >>> Epidermal growth factor; fibroblast growth factor; PBS; CSF/CNS (intrathecal, lumbar region); Mice; 2001; 7 days; Controls received mp w/ vehicle; animal info (100 days old); no body weight changes after implantation of pumps; cannula used for IT cannulation.

P8408 Proudfoot,C.J., Garry,E.M., Cottrell,D.F., Rosie,R., Anderson,H., Robertson,D.C., Fleetwood-Walker,S.M., Mitchel,R. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. CURRENT BIOLOGY 2006; 16(-16-):1591-1605. >>> Oligonucleotide, phosphorothioate antisense; Oligonucleotide, phosphorothioate missense; Saline, sterile; CSF/CNS (intrathecal); Rat; 2001; 2002; 5, 13-16 days; Controls received mp w/ missense oligo; antisense (TRPM8, rat); animal info (male, Wistar, 120-250g., chronic constriction sciatic nerve injury).

P9013 Ruggieri,MR Sr, Braverman,A.S., D'Andrea,L., Simpkiss,B., Kozin,S.H., Pontari,M.A., Betz,R., Barbe,M.F. Functional reinnervation of the canine bladder after spinal root transection and immediate end-on-end repair. Journal of Neurotrauma 2006; 23(-7-):1125-1136. >>> Brain-derived neurotrophic factor; CSF/CNS (spinal cord, intrathecal); Dog; 2002; 14 days; Controls received mp w/ saline; dose-response; peptides; post io. care (ketoprofen); animal info (female, mongrel hound, 6-12 months old, 18-22 kg., bladder denervation); mp connected to silicone cuff surrounding spinal cord root bundles (2).

P8320 Rygh,L.J., Suzuki,R., Rahman,W., Wong,Y., Vonsy,J.L., Sandhu,H., Webber,M., Hunt,S., Dickenson,A.H. Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons. European Journal of Neuroscience 2006; 24(-3-):761-772. >>> Oligodeoxynucleotide, phosphorothioate antisense; oligodeoxynucleotide, phosphorothioate, mismatch; Saline; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle or mismatch ODN or no treatment; antisense (zif268); animal info (male, Sprague-Dawley, 130-150 grams); dye injections used to confirm cannula placement.

P8011 Tai,Y.H., Wang,Y.H., Wang,J.J., Tao,P.L., Tung,C.S., Wong,C.S. Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats. Pain 2006; 124(-1-2-):77-86. >>> Amitriptyline; morphine; Saline; CSF/CNS (intrathecal); SC; Rat; 2001; 5 days; Tolerance; animal info (male, Wistar, 350-400 grams); behavioral study.

P7928 Toth,C., Brussee,V., Martinez,J.A., McDonald,D., Zochodne,D.W. Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin. Neuroscience 2006; 139(-2-):429-449. >>> Insulin; Saline; CSF/CNS (intrathecal, lumbar, peroneal nerve); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (adult male, Sprague-Dawley, 250-300 grams); silicone catheters (0.012" x 0.025") used between L6-S1 vertebrae; nerve perfusion chamber used for nerve infusion; nerve injury; India Ink in pumps to verify delivery; behavioral testing.

P7829 Toth,C., Brussee,V., Zochodne,D.W. Remote neurotrophic support of epidermal nerve fibres in experimental diabetes. Diabetologia 2006; 49(-5-):1081-1088. >>> Insulin; insulin-like growth factor-1; Saline; SC; CSF/CNS (intrathecal, lumbar); Rat; 2002; 1 month; Controls received mp w/ vehicle; replacement therapy (stz-induced diabetes); pumps replaced after 2 weeks; peptides; animal info (male, Sprague-Dawley, 300-350g.); comparison of SC mp vs. IT mp.

P7994 Vavrek,R., Girgis,J., Tetzlaff,W., Hebert,G.W., Fouad,K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 2006; 129(--):1534-1545. >>> Brain-derived neurotrophic factor; NT-3; Albumin, rat serum; CSF/CNS (left motor cortex, intrathecal, cisterna magna); Rat; 2002; 14 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; SCI (spinal cord injury); dental cement used to secure cannula; NT-3 delivered intrathecally; tissue perfusion (left motor cortex).

P8038 Wilson-Gerwing,T.D., Verge,V.M.K. Neurotrophin-3 attenuates galanin expression in the chronic constriction injury model of neuropathic pain. Neuroscience 2006; 141(-4-):2075-2085. >>> NT-3; PBS; albumin, rat serum; streptomycin; penicillin; CSF/CNS (intrathecal, lumbar); Rat; 2001; 7 days; Post op. care (buprenorphine); animal info (adult, male, wistar, 250-300 grams).

P7797 Zhuang,Z.Y., Wen,Y.R., Zhang,D.R., Borsello,T., Bonny,C., Strichartz,G.R., Decosterd,I., Ji,R.R. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. Journal of Neuroscience 2006; 26(-13-):3551-3560. >>> Peptide, D-JNK inhibitor 1; CSF/CNS (intrathecal); CSF/CNS (dorsal root ganglion); Rat; 2 weeks; 3 days; Controls received mp w/ vehicle, or control peptide; comparison of IT injections vs. mp; enzyme inhibitor (c-Jun-N-terminal kinase); peptides; animal info (male, Sprague-Dawley, 220-260g., spinal nerve ligation); mp primed 3hrs in saline.