References on Intrathecal Administration of Agents Using ALZET® Osmotic Pumps

16338 Figueroa, J. D., Serrano-Illan, M., Licero, J., Cordero, K., Miranda, J. D., De Leon, M. Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury. J Neurotrauma 2016; 33(-15-):1436-49. >>> Oligonucleotides, scramble nontargeting; siRNA; Ethanol; Intrathecal; Rat; 2001; Controls received mp w/ vehicle; animal info (Young adult female Sprague-dawley rats); good methods (pg 1443); spinal cord injury;“Pumps were primed with DHA-albumin complex (DHA), FABP5 siRNA, and vehicle controls” (pg 1443); ALZET rat intrathecal catheter used;.

16282 Zhang, K., Ramamurthy, S., Prihoda, T. J., Eckmann, M. S. Effect of delayed intrathecal administration of capsaicin on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats. J Pain Res 2014; 7(--):547-54. >>> Capsaicin; Saline, Tween 80, Ethanol; CSF/CNS (intrathecal); Rat; 2001D, 2001; Controls received mp w/ vehicle; animal info ( Male adult Sprague Dawley rats, 250-300 g); 1.5% Ethanol, 1.5% Tween 80 used; good methods (pg 548, 549); ischemia (sciatic nerve); behavioral testing (Plantar Test, Von Frey Test); Ligature of the sciatic nerve (Chronic constriction injusry of sciatic nerve); Therapeutic indication (Neuropathic Pain); Dose (1.5 ug/ul);.

16264 Tsenkina, Y., Ricard, J., Runko, E., Quiala-Acosta, M. M., Mier, J., Liebl, D. J. EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury. Cell Death Dis 2015; 6(--):e1922. >>> EphrinB3; PBS; CSF/CNS (intrathecal); Mice; 1007D; Controls received mp w/ vehicle; animal info (Female wild type (WT), EphB3 knockout EphB3−/−55), PLP-GFP-WT, PLP-GFP-EphB3−/− mice (2–3 months of age, weighing 26±6 g)); ALZET brain infusion kit 3 used; good methods (pg. 8); spinal cord injury; behavioral testing (locomotor behavior); Dose (100 ug/ml);.

16199 Li, R., Qi, F., Zhang, J., Ji, Y., Zhang, D., Shen, Z., Lei, W. Antinociceptive effects of dexmedetomidine via spinal substance P and CGRP. Transl Neurosci 2015; 6(-1-):259-264. >>> Dexmedetomidine, BRL44408; CSF, artificial; CSF/CNS (intrathecal); rat; 2001; Controls received mp w/ vehicle; animal info: Wistar rats (both male and female) weighing 200-250 g; functionality of mp verified by levels of behavior from rats; dose-response (xpg 260-261); spinal cord injury; behavioral testing (mechanical sensitivity of the hindpaw); Intrathecal catheter used; BRL44408 is anǝ2-AR antagonist; Dose: 20, 50ǨM (DEX); 15,50ǨM (BRL44408).

16162 Ramirez-Jarquin, U. N., Tapia, R. Neuropathological characterization of spinal motor neuron degeneration processes induced by acute and chronic excitotoxic stimulus in vivo. Neuroscience 2016; 331(--):78-90. >>> AMPA; Phosphate buffer; CSF/CNS (intrathecal); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Wistar, 270-300g); neurodegenerative (amyotrophic lateral sclerosis); post op. care (IM penicillin); behavioral testing (rotarod, paw grip endurance; stride analysis); AMPA aka a-amino-3- hydroxy-5-methyl-4-isoxazoleacetic acid; pumps primed for 48 hours in 37C saline; used surgical clips;.

16111 Dabrowski, W., Kwiecien, J. M., Rola, R., Klapec, M., Stanisz, G. J., Kotlinska-Hasiec, E., Oakden, W., Janik, R., Coote, M., Frey, B. N., Turski, W. A. Prolonged Subdural Infusion of Kynurenic Acid Is Associated with Dose-Dependent Myelin Damage in the Rat Spinal Cord. PLoS One 2015; 10(-11-):e0142598. >>> Kynurenic Acid; PBS; CSF/CNS (intrathecal); rat; 2ML1; Controls received mp w/ vehicle; animal info: 42 healthy adult rats; spinal cord injury; post op. care (ketoprofen); Rat intrathecal catheter used; Dose: 0.0002 pmol/min, 0.01 nmol/min, 0.1 nmol/min, 1 nmol/min and 10 nmol/min of Kynurenic acid.

16077 Zendedel, A., Johann, S., Mehrabi, S., Joghataei, M. T., Hassanzadeh, G., Kipp, M., Beyer, C. Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. Mol Neurobiol 2016; 53(-5-):3063-75. >>> Stromal cell-derived factor-1, alpha; PBS; BSA; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 14 weeks old, 350-400g); 1% BSA used; post op. care (saline rehydration; baytril 0.3 ml SC BID; manual bladder emptying BID); behavioral testing (BBB locomotor test); immunology;.

16076 Zadina, J. E., Nilges, M. R., Morgenweck, J., Zhang, X., Hackler, L., Fasold, M. B. Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine. Neuropharmacology 2016; 105(--):215-27. >>> Morphine; endomorphine analog; Saline; CSF/CNS (intrathecal); rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-400g); half-life (p. 219); behavioral testing (tail flick test; rotarod testing); stability verified by (internal testing; stability>1 year at 37C); pumps primed in 37C saline for 16 hours; used PE-8 IT catheter; Dose (2 ug/hr morphine; 0.056-0.075 ug/hr analog);.

16047 Tsai, R. Y., Wang, J. C., Chou, K. Y., Wong, C. S., Cherng, C. H. Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression. J Formos Med Assoc 2016; 115(-6-):445-54. >>> Morphine; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (male, Wistar); behavioral testing (tail-flick); Dose (15 ug/h);.

16033 Rakesh Kumar,, K. H. Reeta,, Subrata Basu Ray  Indian Journal of Experimental Biology 2014; 52(--):317-322. >>> loperamide; morphine; PEG, saline, ethanol; CSF/CNS (intrathecal); rat; 2ML2; Controls received mp w/ vehicle; animal info (adult male Sprague-dawley rats, 275-350 g); dose-response (pg 319, 320); good methods (pg. 317-318); post op. care (neomycin ointment and perioperative ketoprofen [3 mg/kg, im] given); behavioral testing (stepping placing, righting reflex, and Hargreaves paw withdrawal test); delayed delivery (lynch coil filled with saline used to delay administration of drug by 3 days; ); Dose: Morphine and Loperamide ( 0.5,1, and 2 uL/hr).

15968 Lefevre, Y., Amadio, A., Vincent, P., Descheemaeker, A., Oliet, S. H., Dallel, R., Voisin, D. L. Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats. Neurosci Lett 2015; 603(--):42-7. >>> Fluoroacetate; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (male, adult, Wistar, 150-175g); Dose (5 nmoles/hr);.

15962 Lin, S. L., Chang, F. L., Ho, S. Y., Charoenkwan, P., Wang, K. W., Huang, H. L. Predicting Neuroinflammation in Morphine Tolerance for Tolerance Therapy from Immunostaining Images of Rat Spinal Cord. PLoS One 2015; 10(-10-):e0139806. >>> Morphine; gabapentin; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (male, WIstar, 320-400g); behavioral testing (anti-nociceptive test; ); dependence; Dose (Morphine 15 ug/h; gabapentin 15 ug/h);.

15923 Oladosu, F. A., Conrad, M. S., O'Buckley, S. C., Rashid, N. U., Slade, G. D., Nackley, A. G. Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia. PLoS One 2015; 10(-8-):e0135711. >>> RNA, small interfering 13 antisense; CSF, artifical; CSF/CNS (intrathecal); Mice; Controls received mp w/ sense siRNA; animal info (C57BL6J or CXB7/ByJ, 8-12 weeks old, 20-30g);.

15913 Karalija, A., Novikova, L. N., Kingham, P. J., Wiberg, M., Novikov, L. N. The effects of N-acetyl-cysteine and acetyl-L-carnitine on neural survival, neuroinflammation and regeneration following spinal cord injury. Neuroscience 2014; 269(--):143-51. >>> L- N-acetyl-cysteine; O-acetyl-L-canitine; saline; Intrathecal; rats; 2002; Controls received mp w/ vehicle; animal info (adult, 10-12 week female Sprague-Dawley rats); pumps replaced every 2 weeks; spinal cord injury; stab wound in dorsal root entry zone of C3 spinal cervical segment; post op. care (given analgesic Finadyne, normal saline, and benzylpenicillin; each animal housed alone); Peptides ALC, NAC; NAC aka N-Acetyl-cysteine; ALC aka acetyl-L-carnitine; Dose: 2.4 mg/day for NAC, 0.9 mg/day for ALC.

15881 Wu, D., Klaw, M. C., Connors, T., Kholodilov, N., Burke, R. E., Tom, V. J. Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar. J Neurosci 2015; 35(-31-):11068-80. >>> Chondroitinase ABC; PBS; trehalos; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 225-250g); spinal cord injury; post op. care (buprenorphine, cefazolin, Lactated Ringer's solution, bladders manually expressed BID);"Because ChABC alone is thermolabile, we mixed it with the sugar trehalos to thermostabilize it"pg 11069; pumps primed in 37C saline evernight;.

15871 Ruban, A., Malina, K. C., Cooper, I., Graubardt, N., Babakin, L., Jona, G., Teichberg, V. I. Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment. Neurodegener Dis 2015; 15(-4-):233-42. >>> Kanic acid; cyclothiazide; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; animal info (male, Wistar, 8-9 weeks old, 240-250g); pumps replaced every week; neurodegenerative (ALS amyotrophic lateral sclerosis); behavioral testing (rotarod testing); pumps primed in 37C sterile saline overnight; catheter placement verified by visual examination;.

15853 Yamanaka, H., Kobayashi, K., Okubo, M., Noguchi, K. Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator. Neuroscience 2016; 314(--):189-99. >>> Homocysteine; tPA; PBS; CSF/CNS (intrathecal); Rat; 2001; 2001D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); dose-response (pg195); behavioral testing (mechanical withdrawal threshold); Dose (homocysteine 1.2 umol/day or 120 nmol/day; tPA 2 ug/day);.

15780 Brigitte Koenig, Daniel Pape, Owen Chao, Jordana Bauer, Barbara Grimpe  Experimental Neurology 2016; 276(--):51-58. >>> DNAXT-1as; CSF/CNS (intrathecal); Rat; 1007D; Controls received mp w/ control enzyme or PBS; animal info (female, Wistar, 200-250g); pumps replaced every week; pumps replaced every week; spinal cord injury; post op. care (Baytril; manual bladder emptying; Rimadyl); behavioral testing (horizontal ladder task); used self-made intrathecal catheter from 32-gauge polyurethane; enzyme inhibitor (DNA enzyme of mRNA of xylosyltransferase-1);.

15777 Zongming Jiang, Shaoyong Wu, Xiujuan Wu, Junfeng Zhong, Anqing Lv, Jing Jiao, Zhonghua Chen  International Journal of Cancer 2016; 138(--):2013-2020. >>> Rapamycin; CTOP; LY297002; DMSO; saline; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (Wistar, 200-250g); 50% DMSO used; cancer (breast; bone); dose-response (pg 2015); behavioral testing (hindpaw withdrawal latency); Rapamycin is an mTOR antagonist; CTOP is an MOR antagonist; LY297002 an a PI3K inhibitor;.

15762 Pei-cai FU, Rong-hua TANG, Yue WAN, Min-jie XIE, Wei WANG, Xiang LUO, Zhi-yuan YU  J Huazhong Univ Sci Technol[Med Sci] 2016; 36(-1-):31-36. >>> Fasudil; Saline; CSF/CNS (intrathecal); Rat; 1007D; Controls received mp w/ vehicle; animal info (male, Dprague Dawley, adult, 260-300g); animal info (male, Dprague Dawley, adult, 260-300g); behavioral testing (BBB behaviorial testing); Dose (180 ug/day);.

15760 Eric E. Ewan, Theo Hagg  journal of Neurotrauma 2016; 33(--):269-277. >>> Carnitine, acetyl-L-; PBS; CSF/CNS (intrathecal); Rat; 2001; animal info (female, Sprague Dawley, 200g); spinal cord injury; post op. care (wound rinced in steril saline, bacitracin applied topically, gentamicin IM 0, 2 or 4 days later, buprenorphine IM every 12 hours, bladders manually expressed BID); behavioral testing (locomotor function, grid walking, open field); pumps primed overnight; pumps removed after 6 days; Dose (1 mg/day);.

15757 Ciro De Luca, Leonilde Savarese, Anna Maria Colangelo, Maria Rosaria Bianco, Giovanni Cirillo, Lilia Alberghina, Michele Papa  Cell Mol Neurobiol 2016; (-36-):37-46. >>> Nerve growth factor, b-; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); Cannula placement verified via induced lower body paralysis (IT lidocane injection); spared nerve injury; Dose (12 ug/kg/day);.

15718 Vipin Arora,, Carlos Eduardo Morado-Urbina,, Carol A. Aschenbrenner,, Ken-ichiro Hayashida,, FuZhou Wang,, Thomas J. Martin,, James C. Eisenach,, and Christopher M. Peters  The Journal of Pain 2016; 17(-2-):190-202. >>> Atipamezole; CSF/CNS (intrathecal); rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 180-250g); dose-response (pg197); atipamezole is a selective alpha2 AR antagonist; Dose (0, 50, 100, 200 ug/day);.

15215 Hawryluk, G.W.J., Spano, S., Chew, D., Wang, S., Erwin, M., Chamankhah, M., Forgione, N., Fehlings, M.G. An Examination of the Mechanisms by Which Neural Precursors Augment Recovery Following Spinal Cord Injury: A Key Role for Remyelination. CELL TRANSPLANTATION 2014; 23(-3-):365-380. >>> Epithelial growth factor; fibroblast growth factor; platelet-derived growth factor; CSF/CNS (intrathecal); Rat; 1007D; Animal info (female, Wistar, 10-12 weeks old); spinal cord injury; post op. care (bladders manually evacuated TID, Minocycline 50 mg/kg 10 days, cyclosporine 10 mg/kg); behavioral testing (open field test); immunology;.

15182 Okada-Ogawa, A., Nakaya, Y., Imamura, Y., Kobayashi, M., Shinoda, M., Kita, K., Sessle, B.J., Iwata, K., Okada-Ogawa, A. Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection. EXPERIMENTAL NEUROLOGY 2015; 267(--):42-52. >>> R-DIOA; DMSO; saline; CSF/CNS (intrathecal); Rat (transgenic); 2001; Controls received mp w/ vehicle; animal info (male, VGAT-Venus Tg); 10% DMSO used; behavioral testing (von Frey filaments); used microsilicon tubing (0.8 mm in diameter) see pg. 44; R-DIOA is a KCC2 (potassium-chloride co-transporter 2) blocker; neuropathic pain;.

15129 Wang, J., Wang, X.F., Wei, J., Wang, M.Y., Wang, M.Y. Hyaluronan Tetrasaccharide Exerts Neuroprotective Effect and Promotes Functional Recovery After Acute Spinal Cord Injury in Rats. NEUROCHEMICAL RESEARCH 2015; 40(--):98-108. >>> Hyaluronan tetrasaccharide; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (Sprague Dawley, 12 weeks old, 250-300g); spinal cord injury; post op. care (Baytril antibacterial applied SC for 3 days); behavioral testing (locomotor activity); immunology;.

15105 Tashiro, S., Shinozaki, M., Mukaino, M., Renault-Mihara, F., Toyama, Y., Liu, M.G., Nakamura, M., Okano, H., Okano, H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2. NEUROREHABILITATION AND NEURAL REPAIR 2015; 29(--):677-689. >>> TrkB/Fc, recombinant human; PBS; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 8-9 weeks old, 190-220g); spinal cord injury; used ALZET intrathecal cathters; pumps removed after 2 weeks;.

15085 Siddiq, M.M., Hannila, S.S., Carmel, J.B., Bryson, J.B., Hou, J.W., Nikulina, E., Willis, M.R., Mellado, W., Richman, E.L., Hilaire, M., Hart, R.P., Filbin, M.T., Siddiq, M.M. Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. JOURNAL OF BIOLOGICAL CHEMISTRY 2015; 290(--):16343-16356. >>> Metallothionein-I/II; Saline, sterile; CSF/CNS (intrathecal); Rat; 1007D; Controls received mp w/ vehicle; animal info (Long Evans, P28); dose-response (p.16347);.

15053 Nieto, F.R., Clark, A.K., Grist, J., Chapman, V., Malcangio, M., Malcangio, M. Calcitonin Gene-Related Peptide-Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen-Induced Arthritis. ARTHRITIS&RHEUMATOLOGY 2015; 67(--):1668-1677. >>> Calcitonin gene-related peptide (8-37); CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (female, Lewis, 180-200g); behavioral testing (Von Frey filaments; Plantar test); immunology; peptides;.

15047 Muramatsu, R., Kuroda, M., Matoba, K., Lin, H.Y., Takahashi, C., Koyama, Y., Yamashita, T., Muramatsu, R. Prostacyclin Prevents Pericyte Loss and Demyelination Induced by Lysophosphatidylcholine in the Central Nervous System. JOURNAL OF BIOLOGICAL CHEMISTRY 2015; 290(--):11515-11525. >>> Iloprost; Saline; CSF/CNS (intrathecal); Mice; 1007D; Controls received mp w/ vehicle; animal info (C57BL6J);.

15022 Fukuoka, T., Noguchi, K., Fukuoka, T. A POTENTIAL ANTI-ALLODYNIC MECHANISM OF GDNF FOLLOWING L5 SPINAL NERVE LIGATION; MITIGATION OF NPY UP-REGULATION IN THE TOUCH SENSE PATHWAY. NEUROSCIENCE 2015; 304(--):240-249. >>> Glial cell line-derived neurotrophic factor; Saline; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, young adult, 220-230g); behavioral testing (paw withdrawal);.

14975 Ishikawa, Y., Imagama, S., Ohgomori, T., Ishiguro, N., Kadomatsu, K., Kadomatsu, K. A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury. NEUROSCIENCE LETTERS 2015; 593(--):13-18. >>> Keratanase II; chondroitinase ABC; Saline; CSF/CNS (intrathecal); Rat; 2006; Controls received mp w/ vehicle; animal info (female, Sprague Dalwey, 200-230g); spinal cord injury; behavioral testing (single pellet reaching task); used silicone tubing; long-term study;.

14969 Hu, J.Z., Zeng, L., Huang, J.H., Wang, G., Lu, H.B., Lu, H.B. miR-126 promotes angiogenesis and attenuates inflammation after contusion spinal cord injury in rats. BRAIN RESEARCH 2015; 1608(--):191-202. >>> miR-126; Saline; CSF/CNS (intrathecal); Rat; 1003D; Controls received mp w/ control agomir; animal info (male, Sprague Dawley, 180-220g); spinal cord injury; post op. care (Ringer's solution administered IP 5 ml, penicillin G 40000 U IM QD for 3 days, bladders manually expressed BID); behavioral testing (locomotor testing, open field); immunology; pumps primed overnight at 37C.

14908 Chen, Y.L., Tsaur, M.L., Wang, S.W., Wang, T.Y., Hung, Y.C., Lin, C.S., Chang, Y.F., Wang, Y.C., Shiue, S.J., Cheng, J.K., Cheng, J.K. Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats. BRITISH JOURNAL OF ANAESTHESIA 2015; 115(--):105-111. >>> Mibefradil; ethosuximide; nickel chloride; Saline; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g, spinal ligation); behavioral testing (von frey filament, hindpaw withdrawal latency);.

14851 Bradesi, S., Karagiannides, I., Bakirtzi, K., Joshi, S.M., Koukos, G., Iliopoulos, D., Pothoulakis, C., Mayer, E.A., Bradesi, S. Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat. PLoS One 2015; 10(--):U148-U167. >>> miR17-5p; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Wistar, 250-275g); post op. care (buprenorphine 0.03 mg/kg); behavioral testing (chronic water avoidance test); pumps primed prior to implantation; catheter positioning verified postmortem;.

14837 Bao, Y.J., Gao, Y.B., Hou, W., Yang, L.P., Kong, X.Y., Zheng, H.G., Li, C.H., Hua, B.J., Hua, B.J. Engagement of signaling pathways of protease-activated receptor 2 and -opioid receptor in bone cancer pain and morphine tolerance. INTERNATIONAL JOURNAL OF CANCER 2015; 137(--):1475-1483. >>> FSLLRY-NH2; Saline; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (Wistar 200-250g); cancer (bone); no stress (see pg. 1476); behavioral testing (mechanical paw withdrawal, thermal hyperalgesia); peptides;.

14780 Zhu, Y., Soderblom, C., Krishnan, V., Ashbaugh, J., Bethea, J.R., Lee, J.K., Lee, J.K. Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury. NEUROBIOLOGY OF DISEASE 2015; 74(--):114-125. >>> Sunitinib malate; DMSO; CSF/CNS (intrathecal); Mice; 1002; Animal info (female, 8 weeks old); functionality of mp verified by use of evans blue dye; 2.5% DMSO used; spinal cord injury; immunology; used ALZET mouse IT catheter;.

14538 Zoerner, B., Bachmann, L.C., Filli, L., Kapitza, S., Gullo, M., Bolliger, M., Starkey, M.L., Rothlisberger, M., Gonzenbach, R.R., Schwab, M.E., Zoerner, B. Chasing central nervous system plasticity: the brainstem's contribution to locomotor recovery in rats with spinal cord injury. Brain 2014; 137(--):1716-1732. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML2; Animal info (female, Lewis, 10 weeks old, 200-250g); spinal cord injury; behavioral testing (locomotor tasks);.

14508 Yin, H.Z., Yu, S., Hsu, C.I., Liu, J., Acab, A., Wu, R., Tao, A.N., Chiang, B.J., Weiss, J.H., Weiss, J.H. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Experimental Neurology 2014; 261(--):1-9. >>> Propanoic acid, amino-beta-methyl; CSF/CNS (intrathecal); Rat (transgenic); 2004; Controls received mp w/ saline; animal info (male, hemizygous SOD1 G93A, 80 days old); neurodegenerative (amyotrophic lateral sclerosis ); toxicology; amino-beta-methylaminopropanoic acid aka beta-N-methylamino-L-alanine aka BMAA; BMAA is a neurotoxin; used PE5 catheter for IT cannulation;.

14505 Yasui, M., Yoshimura, T., Takeuchi, S., Tokizane, K., Tsuda, M., Inoue, K., Kiyama, H., Kiyama, H. A Chronic Fatigue Syndrome Model Demonstrates Mechanical Allodynia and Muscular Hyperalgesia via Spinal Microglial Activation. Glia 2014; 62(--):1407-1417. >>> Minocycline; Saline; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250g); behavioral testing (Randall-Selitto, Von Frey hairs); immunology;.

14492 Xu, C., Klaw, M.C., Lemay, M.A., Baas, P.W., Tom, V.J., Tom, V.J. Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury. Experimental Neurology 2015; 263(--):172-176. >>> Chondroitinase ABC; Trehalos; PBS; monastrol; DMSO; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 225-250g, adult); spinal cord injury; behavioral testing (open field testing); use ReCathCo IT catheter;.

14465 Wang, X.X., Yigitkanli, K., Kim, C.Y., Sekine-Komo, T., Wirak, D., Frieden, E., Bhargava, A., Maynard, G., Cafferty, W.B.J., Strittmatter, S.M., Strittmatter, S.M. Human NgR-Fc Decoy Protein via Lumbar Intrathecal Bolus Administration Enhances Recovery from Rat Spinal Cord Contusion. Journal of Neurotrauma 2014; 31(--):1955-1966. >>> NgR1(310)-Fc, human; PBS; CSF/CNS; CSF/CNS (intrathecal); Rat; 2ML4; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 10-11 weeks old, 220-240g); spinal cord injury; behavioral testing (BBB locomotor scale, grid walking); cyanoacrylate adhesive; used Rat IT catheter for IT infusion; PBS pumps initially implanted, and then replaced 3 days after SCI with vehicle or agent;.

14435 Tatsumi, E., Yamanaka, H., Kobayashi, K., Yagi, H., Sakagami, M., Noguchi, K., Noguchi, K. RhoA/ROCK Pathway Mediates p38 MAPK Activation and Morphological Changes Downstream of P2Y12/13 Receptors in Spinal Microglia in Neuropathic Pain. Glia 2015; 63(--):216-228. >>> H1152; MRS2395; MRS2211; 2Me-SADP; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 1003D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); 5% DMSO used; behavioral testing (hindpaw withdrawal test); H1152 is a ROCK inhibitor; sciatic nerve injury;.

14433 Tassew, N.G., Mothe, A.J., Shabanzadeh, A.P., Banerjee, P., Koeberle, P.D., Bremner, R., Tator, C.H., Monnier, P.P., Monnier, P.P. Modifying Lipid Rafts Promotes Regeneration and Functional Recovery. CELL REPORT 2014; 8(--):1146-1159. >>> Neogenin; PBS; CSF/CNS (intrathecal); Rat; 2002; Controls received mp w/ vehicle; animal info (female, Wistar, adult); spinal cord injury; post op. care (bladders evacuated manually 3 times daily; Clavomax PO BID 62.5 mg); behavioral testing (locomotor function, ladder walk analysis); used ALZET IT catheter; pumps primed in 37C sterile saline overnight;"catheter and pump were sutured extensively to the subcutaneous tissues"pg 11 of supplement;.

14400 Shimizu, K., Matsumoto, K., Noma, N., Matsuura, S., Ohara, K., Komiya, H., Watase, T., Ogiso, B., Tsuboi, Y., Shinoda, M., Hatori, K., Nakaya, Y., Iwata, K., Shimizu, K. Involvement of Trigeminal Transition Zone and Laminated Subnucleus Caudalis in Masseter Muscle Hypersensitivity Associated with Tooth Inflammation. PLoS One 2014; 9(--):U620-U630. >>> PD98059; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ saline; animal info (male, Sprague Dawley, 250-450g); functionality of mp verified by residual volume; used PE45 tubing to catheterize IT space;.

14339 Pajer, K., Feichtinger, G.A., Marton, G., Sabitzer, S., Klein, D., Redl, H., Nogradi, A., Nogradi, A. Cytokine signaling by grafted neuroectodermal stem cells rescues motoneurons destined to die. Experimental Neurology 2014; 261(--):180-189. >>> Antibody, anti-interleukin-1a; antibody, anti-interleukin-6; antibody, tumor necrosis factor-alpha; antibody, macrophage inflammatory protein-1 alpha; CSF/CNS (intrathecal); Rat; 1002; Controls received mp w/ control antibody; animal info (female, Sprague Dawley, adult); functionality of mp verified by decreased activity of targets; used silicone tubing 0.3 mm ID for catheter; catheter was fixed to surrounding muscle with 8-0 sutures; pumps removed after 2 weeks;.

14327 Novrup, H.G., Bracchi-Ricard, V., Ellman, D.G., Ricard, J., Jain, A., Runko, E., Lyck, L., Yli-Karjanmaa, M., Szymkowski, D.E., Pearse, D.D., Lambertsen, K.L., Bethea, J.R., Lambertsen, K.L. Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice. Journal of Neuroinflammation 2014; 11(--):U13-U26. >>> XPro1595; etanercept; Saline; CSF/CNS (intrathecal); Mice; 1003D; Controls received mp w/ vehicle; animal info (female, C57BL6J, adult); ALZET brain infusion kit 3 used; spinal cord injury; post op. care (SC injection of 1 ml lactated Ringer's Fluid; manual bladder expression twice a day; gentamicin 40 mg/kg for 7 days); behavioral testing (catwalk test, gridwalk test, thermal hyperalgesia, open field test); used methylcyano acrylate to affix catheter to T10;.

14289 Mannelli, L.D., Pacini, A., Micheli, L., Tani, A., Zanardelli, M., Ghelardini, C., Mannelli, L.D. Glial role in oxaliplatin-induced neuropathic pain. Experimental Neurology 2014; 261(--):22-33. >>> Minocycline HCl; Sodium fluorocitrate; PBS; CSF/CNS (intrathecal); Rat; 2004; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 200-250g); behavioral testing (paw pressure test; von frey test; rota-rod test ); pumps primed overnight in 37C PBS;.

14280 Lin, C.P., Kang, K.H., Lin, T.H., Wu, M.Y., Liou, H.C., Chuang, W.J., Sun, W.Z., Fu, W.M., Fu, W.M. Role of Spinal CXCL1 (GROalpha) in Opioid Tolerance A Human-to-rodent Translational Study. Anesthesiology 2015; 122(--):666-676. >>> CXCL1; antibody, CXCL1; CXCR2 antileukine hexapeptide; morphine; CSF/CNS (intrathecal); Rat; Controls received mp w/ saline; animal info (male, Sprague Dawley, 250-275g, adult); behavioral testing (tail flick response); dependence; used PE10 intrathecal catheter tubing;.

14276 Liang, P., Liu, J.R., Xiong, J.S., Liu, Q., Zhao, J.X., Liang, H.S., Zhao, L.W., Tang, H.T., Liang, P. Neural Stem Cell-Conditioned Medium Protects Neurons and Promotes Propriospinal Neurons Relay Neural Circuit Reconnection After Spinal Cord Injury. CELL TRANSPLANTATION 2014; 23(--):S45-S56. >>> Neural stem cell-conditioned medium, human fetal; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ NSC culture medium; animal info (female, Wistar, 8-10 weeks old, 260-300g); pumps replaced every week; spinal cord injury; post op. care (Bicillin injection 20000 U/day, bladder massage); behavioral testing (locomotor activity); pumps primed in 37C saline overnight; pumps removed after 4 weeks of infusion;.

14251 Kwiecien, J.M., Jarosz, B., Urdzikova, L.M., Rola, R., Dabrowski, W., Kwiecien, J.M. Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model. FOLIA NEUROPATHOLOGICA 2015; 53(--):41-51. >>> Dexamethasone; PBS; CSF/CNS (intrathecal); Rat; 2ML2; Controls received mp w/ vehicle; animal info (Long Evans); spinal cord injury; post op. care (ketoprofen 0.3 ml of 10 mg/ml injection, saline administration 1-2 times daily); behavioral testing (Open field testing);"Subdural infusion of dexamethasone, a powerfully anti-inflammatory, stable, synthetic analogue of glucocorticoids, allowed for circumvention of the blood-brain barrier and apparently for achieving a sufficiently high concentration of this drug in the cerebrospinal fluid in proximity of the crush lesion to prevent severe, phagocyte-rich inflammation."pg 48; used rat IT catheter; dose: 2 mg/ml.

14204 Frias, B., Santos, J., Morgado, M., Sousa, M.M., Gray, S.M.Y., McCloskey, K.D., Allen, S., Cruz, F., Cruz, C.D., Cruz, C.D. The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Development of Neurogenic Detrusor Overactivity (NDO). Journal of Neuroscience 2015; 35(--):2146-2160. >>> Brain-derived neurotropic factor; TrkB-Ig2; Tris buffer; glycerol; CSF/CNS (intrathecal); Rat; 2001; 2004; Controls received mp w/ saline; animal info (female, Wistar, 250-275g); 10% glycerol used; spinal cord injury; no stress (see pg. 2154); post op. care (ciprofloxacin 1 mg/kg IP injection; bladders manually emptied twice a day); used silicone catheter;.

14696 Chu, J., Li, J.G., Joshi, Y.B., Giannopoulos, P.F., Hoffman, N.E., Madesh, M., Pratico, D., Pratico, D. Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer's Disease. Biological Psychiatry 2015; 77(--):720-728. >>> Z-DEVD-FMK; CSF/CNS (intrathecal); Mice (transgenic); 1007D; Animal info (Tg2576, 15 months old; 3Tg, 10 months old); neurodegenerative (Alzheimer's disease); z-DEVD-fmk is a caspase-3 inhibitor;.

14689 Chehrehasa, F., Cobcroft, M., Young, Y.W., kay-Sim, A., Goss, B., kay-Sim, A. An Acute Growth Factor Treatment that Preserves Function after Spinal Cord Contusion Injury. Journal of Neurotrauma 2014; 31(--):1807-1813. >>> Vascular endothelial growth factor; platelet-derived growth factor-BB; PBS; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ saline; animal info (female, Wistar, 20-25 weeks, 300g); spinal cord injury; post op. care (cephalothin; buprenorphine; manual bowel and bladder expression BID); behavioral testing (locomotor behavior; gaid and footprint analysis); used Rat intrathecal catheter; pumps primed in 37C saline overnight;.

14655 Alluin, O., ivet-Mongrain, H., Gauthier, M.K., Fehlings, M.G., Rossignol, S., Karimi-Abdolrezaee, S., Karimi-Abdolrezaee, S. Examination of the Combined Effects of Chondroitinase ABC, Growth Factors and Locomotor Training following Compressive Spinal Cord Injury on Neuroanatomical Plasticity and Kinematics. PLoS One 2014; 9(--):U603-U621. >>> Chondroitinase ABC; platelet-derived growth factor-AA; basic fibroblast growth factor; epidermal growth factor;; Saline; rat serum albumin; CSF/CNS (intrathecal); Rat; 1007D; Controls received mp w/ vehicle; animal info (female, Wistar, adult, 250-275g); spinal cord injury; behavioral testing (treadmill locomotion; coordination); used ALZET rat intrathecal catheter;.

14641 Micheli, L., Mannelli, L.D., Guerrini, R., Trapella, C., Zanardelli, M., Ciccocioppo, R., Rizzi, A., Ghelardini, C., Calo, G., Mannelli, L.D. Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. European Journal of Pharmacology 2015; 754(--):79-87. >>> Morphine; UFP-112; UFP-113; Saline, sterile; CSF/CNS (intrathecal); Rat; Control animals received mp w/ vehicle; animal info (male, Sprague Dawley, Wistar, NOP -/-, male); ALZET intrathecal catheter used; UFP-112 is a full NOP agonist (N/OFQ peptide ); UFP-113 is a partial NOP agonist.

14610 Lu, Y., Jiang, B.C., Cao, D.L., Zhang, Z.J., Zhang, X., Ji, R.R., Gao, Y.J., Gao, Y.J. TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-alpha and IL-1beta signaling. Pain 2014; 155(--):2618-2629. >>> Oligonucleotide, antisense; oligonucleotide, mismatch; CSF/CNS (intrathecal); Mice; 1007D; Animal info (ICR, adult, male, 8 wks old); PE8 catheter used; antisense (TRAF6); neuropathic pain.

14599 Pan, H.C., Shen, Y.Q., Loers, G., Jakovcevski, I., Schachner, M., Schachner, M. TEGASEROD, A SMALL COMPOUND MIMETIC OF POLYSIALIC ACID, PROMOTES FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY IN MICE. Neuroscience 2014; 277(--):356-366. >>> Tegaserod; DMSO; PBS; CSF/CNS (intrathecal); Mice; 1002; Control animals received mp w/ vehicle; animal info (female, 3-4 mo old, C57BL/6J); 0.3% DMSO used:"The pump was placed subcutaneously and the catheter was fixed to the tissue with a 6-0 filament"; spinal cord injury; no stress or adverse effects"During the six-week experimental time period, no infections, overall paralyses or abnormal behavior of implanted mice were observed."pg 358.

14598 Shaqura, M., Khalefa, B.I., Shakibaei, M., Zoellner, C., Al-Khrasani, M., Fuerst, S., Schaefer, M., Mousa, S.A., Mousa, S.A. New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy. Neuropharmacology 2014; 85(--):142-150. >>> Nerve growth factor, beta; albumin, rat serum; CSF, artificial; CSF/CNS (intrathecal); Rat; 2001; Control animals received mp w/ animal info (male, Wistar, STZ induced diabetes).

14592 Smith, E.S., Jonason, A., Reilly, C., Veeraraghavan, J., Fisher, T., Doherty, M., Klimatcheva, E., Mallow, C., Cornelius, C., Leonard, J.E., Marchi, N., Janigro, D., Argaw, A.T., Pham, T., Seils, J., Bussler, H., Torno, S., Kirk, R., Howell, A., Evans, E.E., Paris, M., Bowers, W.J., John, G., Zauderer, M., Zauderer, M. SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease. NEUROBIOLOGY OF DISEASE 2015; 73(--):254-268. >>> Antibody, anti-SEMA 4D, monoclonal; CSF/CNS (intrathecal, subarachnoid space); Rat; 2002; Control animals received mp w/ control IgG; animal info (Sprague Dawley, male, 8 wks old).

14562 Loers, G., Cui, Y.F., Neumaier, I., Schachner, M., Skerra, A., Schachner, M. A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord. Biochemical Journal 2014; 460(--):437-446. >>> alpha, L1 Fab; PBS; CSF/CNS (intrathecal); Mice; 1002; animal info (female, C57BL6J, 3-4 months old); spinal cord injury; behavioral testing (locomotor activity); used flame streteched vinyl catheter tubing; no stress"During the 6-week behavioural observation period, no adverse effects of the pump implantation, such as infection, paralysis or aberrant behaviour, were observed."pg 439; post op. care (tacrolimus PO IP injection 1 mg/kg 6 weeks);.

13952 Yang, F., Whang, J., Derry, W.T., Vardeh, D., Scholz, J. Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat. Pain 2014; 155(-2-):356-366. >>> Pregabalin; PBS; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 2-3 months old); dose-response (p.359, fig. 1); behavioral testing (open field behavior; paw withdrawal; righting reflex); used IT catheter; cather placement verified; pregabalin is an analgesic; spared nerve injury;.

13948 Zemmar, A., Weinmann, O., Kellner, Y., Yu, X.Z., Vicente, R., Gullo, M., Kasper, H., Lussi, K., Ristic, Z., Luft, A.R., Rioult-Pedotti, M., Zuo, Y., Zagrebelsky, M., Schwab, M.E., Zemmar, A. Neutralization of Nogo-A Enhances Synaptic Plasticity in the Rodent Motor Cortex and Improves Motor Learning in Vivo. Journal of Neuroscience 2014; 34(--):8685-8698. >>> Antibody, anti-Nogo-A; CSF/CNS (intrathecal); Rat; 2ML1; Controls received sham surgery; animal info (male, Sprague Dawley, 5-6 weeks old, 190-220g); functionality of mp verified by immunohistochemistry and Western blotting; behavioral testing (motor skill task); brain tissue distribution; learning;.

13898 Pettersson, L.M.E., Geremia, N.M., Ying, Z.X., Verge, V.M.K., Pettersson, L.M.E. Injury-Associated PACAP Expression in Rat Sensory and Motor Neurons Is Induced by Endogenous BDNF. PLoS One 2014; 9(--):U629-U640. >>> Antibody, brain-derived neurotrophic factor; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ control IgG; animal info (male, Wistar, 250-300tg); post op. care (buprenorphine 0.05-0.1 mg/kg SC); peripheral nerve injury;.

13854 Oono, M., Okado-Matsumoto, A., Shodai, A., Ido, A., Ohta, Y., Abe, K., Ayaki, T., Ito, H., Takahashi, R., Taniguchi, N., Urushitani, M. Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. Journal of Neurochemistry 2014; 128(-3-):403-418. >>> Cystamine; CSF/CNS (intrathecal); Mice; 2006; Controls received mp w/ vehicle; animal info (WT C57BL6 or mSOD1, 30 weeks old); neurodegenerative (amyotrophic lateral sclerosis); immunology; stability"Cystamine hydrochloride has previously been shown to be very stable for long time use in the osmotic minipump"pg 417; long-term study;.

13847 Li, Z.W., Li, J.J., Wang, L., Zhang, J.P., Wu, J.J., Mao, X.Q., Shi, G.F., Wang, Q., Wang, F., Zou, J., Li, Z.W. Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury. Journal of Neuroinflammation 2014; 11(--):U1-U16. >>> PD168393; DMSO; Hank's balanced salt solution; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle or surgery only; animal info (adult, Sprague Dawley, adult, 220-250g); 5% DMSO used; spinal cord injury; post op. care (bladders expressed twice daily); used 32g catheter; pumps removed after 14 days;.

13829 Karalija, A., Novikova, L.N., Kingham, P.J., Wiberg, M., Novikov, L.N., Karalija, A. THE EFFECTS OF N-ACETYL-CYSTEINE AND ACETYL-L-CARNITINE ON NEURAL SURVIVAL, NEUROINFLAMMATION AND REGENERATION FOLLOWING SPINAL CORD INJURY. Neuroscience 2014; 269(--):143-151. >>> N-acetyl-cysteine ; acetyl-l-carnitine hydrochloride; Saline; CSF/CNS (intrathecal); Rat; 2002; Animal info (female, Sprague Dawley, 10-12 weeks); pumps replaced every 14 days; good methods (p144); spinal cord injury;.

13813 Itokazu, T., Hayano, Y., Takahashi, R., Yamashita, T., Yamashita, T. Involvement of Wnt/beta-catenin signaling in the development of neuropathic pain. NEUROSCIENCE RESEARCH 2014; 79(--):34-40. >>> XAV939; wnt3a, recombinant; DMSO; PBS; BSA; CSF/CNS (intrathecal); Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 8-10 weeks old, 200-250g); 10% DMSO used; behavioral testing (von Frey filaments; withdrawal threshold); Catheter placement verified via 25ul of 2% lidocane followed by 10ul saline flush - hind paw paralysis indicated success; sciatic nerve ligation;.

13743 Chu, J., Lauretti, E., Craige, C.P., Pratico, D., Pratico, D. Pharmacological Modulation of GSAP Reduces Amyloid-beta Levels and Tau Phosphorylation in a Mouse Model of Alzheimer's Disease with Plaques and Tangles. JOURNAL OF ALZHEIMERS DISEASE 2014; 41(--):729-737. >>> Imatinib; Cerebrospinal fluid, artificial; CSF/CNS (intrathecal); Mice (transgenic); 1007D; Controls received mp w/ vehicle; animal info (triple transgenic ABBP, PS1, P301L); neurodegenerative (Alzheimer's);"Since it is known that the drug does not penetrate the blood-brain barrier efficiently, it is possible that the contradictory results reflect this property of the drug. For this reason in the current study, we delivered Imatinib by means of implanted osmotic minipumps directly in the brains of the triple transgenic mice"pg 730; Imatinib aka STI571 akd Gleevec; used dental cement;.

13613 Nadeau, J.R., Wilson-Gerwing, T.D., Verge, V.M.K. Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons. Glia 2014; 62(-5-):763-777. >>> Oligonucleotide, antisense p75; PBS; rat serum albumin; streptomycin; penicillin; CSF/CNS (intrathecal); Rat; 2001; Controls received mp w/ control oligonucleotide; animal info (male, Wistar, 250-300g); functionality of mp verified by fluorescent tagged AS; antisense (oligonucleotide p75); post op. care (Temgesic SC 0.1-0.2 mg/kg); gene therapy; used silastic tubing; pumps and tubing primed overnight in PBS; 100U/ml streptomycin; 100U/ml penicillin; 1mg/ul rat serum albumin;.

13605 Lindau, N.T., Baenninger, B.J., Gullo, M., Good, N.A., Bachmann, L.C., Starkey, M.L., Schwab, M.E. Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy. Brain 2014; 137(-;-):739-756. >>> Antibody, mouse monocolonal anti-Nogo-A 11C7; uridine, anti-bromodeoxy; CSF/CNS (intrathecal); Rat; 2ML2; Controls received mp w/control antibody; animal info (female, Long Evans, 3-7 months, 230-400g); ischemia (photothrombic); post op. care (Rimadyl 2.5mg/kg, Baytril 5mg/kg for 3 days; mannitol 20% injection 17 mg/kg; heating pad for 24h); behavioral testing (pellet grasping); pump and catheter removed after 2 weeks; used 32 gauge intrathecal catheter;.


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What researchers are saying...

“...opioid and nonopioid analgesics were continuously infused from subcutaneously implanted osmotic mini-pumps, a convenient modality of drug delivery that allows for drug delivery at constant rate for prolonged periods of time without experimenter intervention.” Bruins Slot et al., Pharmacology, Biochemistry and Behavior 2002;72:943-951.