References on the Intravenous Administration of Agents Using ALZET® Osmotic Pumps

16352 Garcia-Alvarez, A., Pereda, D., Garcia-Lunar, I., Sanz-Rosa, D., Fernandez-Jimenez, R., Garcia-Prieto, J., Nuno-Ayala, M., Sierra, F., Santiago, E., Sandoval, E., Campelos, P., Aguero, J., Pizarro, G., Peinado, V. I., Fernandez-Friera, L., Garcia-Ruiz, J. M., Barbera, J. A., Castella, M., Sabate, M., Fuster, V., Ibanez, B. Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension. Basic Res Cardiol 2016; 111(-4-):49. >>> BRL37344; Saline; IV (right jugular vein); pigs; 2ML2; Controls received mp w/ vehicle; animal info (pig, 4 months old, 45 kg); functionality of mp verified by plasma levels; cardiovascular; antihypertensive; PE-60 catheter used for IV application; BRL37344 is a B3AR agonist; Dose (10 ug/kg/day BRL37344);.

16315 Carusillo Theriault, B., Woo, S. K., Karimy, J. K., Keledjian, K., Stokum, J. A., Sarkar, A., Coksaygan, T., Ivanova, S., Gerzanich, V., Simard, J. M. Cerebral microbleeds in a neonatal rat model. PLoS One 2017; 12(-2-):e0171163. >>> Endotoxin, LPS; IV (jugular); Rat (Pregnant); 2001D; animal info (Pregnant Wistar); post op. care (Buprenorphine (0.3±0.5 mg/kg) every 12 hours, as needed.); Dose (600 ng/hr); Resultant plasma level (4.5+/-0.9 EU/mL LPS);.

16302 Benlloch, M., Obrador, E., Valles, S. L., Rodriguez, M. L., Sirerol, J. A., Alcacer, J., Pellicer, J. A., Salvador, R., Cerda, C., Saez, G. T., Estrela, J. M. Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism. Antioxid Redox Signal 2016; 24(-17-):974-90. >>> Pterostilbene, Corticosterone; DMSO, Ethanol; PEG400; IV (jugular); mice; Controls received mp w/ vehicle; animal info Female nu/nu nude mice (6–8 weeks); functionality of mp verified by plasma levels, pg 979; functionality of mp verified by plasma levels, pg 979; Pterostilbene is a natural dimethoxylated analog of resveratrol; Mice xenograft models; Dose (50 mg/ml Pter; 0.3 ug/hr corticosterone); Resultant plasma level (pg. 979);.

16204 Luo, D., Zhuang, X., Luo, C., Long, M., Deng, C., Liao, X., Wang, L. Continuous angiotensin-(1-7) infusion improves myocardial calcium transient and calcium transient alternans in ischemia-induced cardiac dysfunction rats. Biochem Biophys Res Commun 2015; 467(-4-):645-50. >>> Angiotensin (1-7); saline; IV (jugular); rat; 2ML4; Controls received mp w/ vehicle and sham operation; animal info: Sprague Dawley adult male rats, 180-220 g; functionality of mp verified by measurements of hemodynamic parameters, the calcium transient, and the heart rate threshold of calcium transient alternans; ischemia (cardiac); post op. care (IP injection of buprenorphine); cardiovascular; peptides;“evaluate impact of Ang-(1e7) on calcium transient (CaT) in cardiomyocytes during the pathogenesis of heart failure” (pg 645); Dose: 24 mg/kg per hour.

16094 Barth, R. F., Yang, W., Nakkula, R. J., Byun, Y., Tjarks, W., Wu, L. C., Binns, P. J., Riley, K. J. Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors. Appl Radiat Isot 2015; 106(--):251-5. >>> N5-2OH; DMSO; CSF/CNS (intracerebral); IV; rat; 2001D; Controls received mp w/ vehicle, untreated controls; %35 of DMSO; cancer (brain tumor; F98 glioma model); tissue perfusion (brain tissue); brain tissue distribution; Animals were irradiated for 5 min at the MITR-II reactor;“intracerebral. administration of BPA did not increase the tumor boron uptake compared to that obtained following i.v. administration” (pg. 252); Dose: 500 ug.

16083 Zhao, J., Liu, T., Liu, E., Li, G., Qi, L., Li, J. The potential role of atrial natriuretic peptide in the effects of Angiotensin-(1-7) in a chronic atrial tachycardia canine model. J Renin Angiotensin Aldosterone Syst 2016; 17(-1-):1470320315627409. >>> Angiotensin (1-7); A-71915; IV (jugular); Dog; animal info (mongrel, 13-17 kg); cardiovascular; peptides; A-71915 is an ANP receptor antagonist; Dose (Ang (1-7) 6 ug/kg/hr; A-71915 0.3 ug/kg/hr);“Ang-(1– 7) dose was selected because 6Ǩg/kg/h is verified as the highest dose that wouldn’t affect blood pressure in our preliminary study” pg 2;.

16013 Ibrahim-Zada, I., Rhee, P., Gomez, C. T., Weller, J., Friese, R. S. Inhibition of sepsis-induced inflammatory response by beta1-adrenergic antagonists. J Trauma Acute Care Surg 2014; 76(-2-):320-7; discussion 327-8. >>> Esmolol; saline; IV (jugular); mice; Controls received mp w/ saline vehicle; animal info (Male C57BL/6J mice aged 8 weeks to 12 weeks); functionality of mp verified by monitoring of animal response using transthoraic chocardiography; dose-response (pg 321, 322 dose response curve); good methods (pg 321); post op. care (buprenorphine 0.025 mg in 1 mL of normal saline injected SC); observation of animals every 12 hours; Dose: emsolol 6.7 ug/kg/min (pg. 321) [10mg/mL];.

15896 Wanger, T., Wetzel, W., Scheich, H., Ohl, F. W., Goldschmidt, J. Spatial patterns of neuronal activity in rat cerebral cortex during non-rapid eye movement sleep. Brain Struct Funct 2015; 220(-6-):3469-84. >>> ; IV (jugular); rat; animal info (male, Wistar, 250-400g); rat jugular catheters only;.

15845 MingWu, Piet Claus, Nina Vanden Driessche, Geert Reyns, Peter Pokreisz, Hilde Gillijns, Ellen Caluwe, Jan Bogaert, Desire Collen, Stefan Janssens  International Journal of Cardiology 2016; 203(--):534-542. >>> Placental growth factor-2, recombinant human; PBS; IV; Pig; 2ML2; Controls received mp w/ vehicle; animal info (Sus Scrofa, 20-25kg); functionality of mp verified by plasma levels; ischemia (myocardial); cardiovascular; Dose (15 ug/kg/day);.

15838 Zenggeng Wang, MD, Qinghua Wu, MD, Xiangbi Nie, MD, Jinghua Guo, MD, Chunli Yang, MD  Journal of Surgical Research 2016; 200(--):283-289. >>> Esmolol; Saline; IV (jugular); Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 8-12 weeks old); cardiovascular; immunology; Dose (6.7 ug/kg/min);.

15270 Alfredo Q. Antoniazzi  Biology of Reproduction 2013; 88(-6-):1-12. >>> interferon-tau, recombinant ovine; BSA; IV (jugular, intrauterine); ewe; 2001D, 1003D; controls received mp w/ vehicle; functionality of mp verified by serum antiviral activity; pumps were anchored in the s.c. space with cyanoacrylate glue; 200 ug/day (uterine vein); 200 ug/day (jugular vein).

15099 Takemori, K., Yamamoto, E., Ito, H., Kometani, T., Takemori, K. Prophylactic effects of elastin peptide derived from the bulbus arteriosus of fish on vascular dysfunction in spontaneously hypertensive rats. LIFE SCIENCES 2015; 120(--):48-53. >>> Prolylglycine; IV (femoral); Rat; 2ML4; Controls received mp w/ saline; animal info (male, SHR/Izm, 15 weeks old); cardiovascular; peptides;.

15055 Nojiri, T., Hosoda, H., Tokudome, T., Miura, K., Ishikane, S., Otani, K., Kishimoto, I., Shintani, Y., Inoue, M., Kimura, T., Sawabata, N., Minami, M., Nakagiri, T., Funaki, S., Takeuchi, Y., Maeda, H., Kidoya, H., Kiyonari, H., Shioi, G., Arai, Y., Hasegawa, T., Takakura, N., Hori, M., Ohno, Y., Miyazato, M., Mochizuki, N., Okumura, M., Kangawa, K., Kangawa, K. Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015; 112(--):4086-4091. >>> Atrial natriuretic peptide; Saline; IV (jugular); Mice (nude); 1002; 2004; Controls received mp w/ vehicle; animal info (BALB/c nu/nu, 6 weeks old); cancer (lung); cardiovascular; immunology; used mouse jugular catheter (#7702); bp measured using tail cuff;.

15005 Li, B., Zeng, M., He, W.M., Huang, X.B., Luo, L., Zhang, H.W., Deng, D.Y.B., Zeng, M. Ghrelin Protects Alveolar Macrophages Against Lipopolysaccharide-Induced Apoptosis Through Growth Hormone Secretagogue Receptor 1a-Dependent c-Jun N-Terminal Kinase and Wnt/beta-Catenin Signaling and Suppresses Lung Inflammation. ENDOCRINOLOGY 2015; 156(--):182-192. >>> Ghrelin; Saline; IV (jugular); Rat; 2001D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 6-7 weeks old, 300 +/- 20g); immunology; pumps primed for 3 hours in 37C saline;.

14962 Hecker, M., Linder, T., Ott, J., Walmrath, H.D., Lohmeyer, J., Vadasz, I., Marsh, L.M., Herold, S., Reichert, M., Buchbinder, A., Morty, R.E., Bausch, B., Fischer, T., Schulz, R., Grimminger, F., Witzenrath, M., Barnes, M., Seeger, W., Mayer, K., Mayer, K. Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial. CRITICAL CARE 2015; 19(--):U1-U13. >>> Fish oil-based lipid emulsion; Soybean oil-based lipid emulsion; IV (jugular); Mice; Controls received mp w/ saline; animal info (ChemR23 -/- or WT Sv129/S1); 10% emulsion used; immunology;.

14528 Zhang, J.L., Yang, W.L., Hu, B.Q., Wu, W., Fallon, M.B., Fallon, M.B. Endothelin-1 Activation of the Endothelin B Receptor Modulates Pulmonary Endothelial CX3CL1 and Contributes to Pulmonary Angiogenesis in Experimental Hepatopulmonary Syndrome. American Journal of Pathology 2014; 184(--):1706-1714. >>> BQ788; Saline; IV (femoral); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300g); cardiovascular; BQ788 is a selective ETb receptor antagonist; common bile duct ligation;.

14488 Xia, M., Boini, K.M., Abais, J.M., Xu, M., Zhang, Y., Li, P.L., Li, P.L. Endothelial NLRP3 Inflammasome Activation and Enhanced Neointima Formation in Mice by Adipokine Visfatin. American Journal of Pathology 2014; 184(--):1617-1628. >>> Visfatin; IV (jugular); Mice; 2002; Controls received mp w/ vehicle; animal info (male, C57BL6J or Asc -/-, 8 weeks old); cardiovascular; immunology; visfatin is an adipokine;.

14322 Ning, C., Wen, J.M., Zhang, Y.J., Dai, Y.B., Wang, W., Zhang, W.R., Qi, L., Grenz, A., Eltzschig, H.K., Blackburn, M.R., Kellems, R.E., Xia, Y., Xia, Y. Excess adenosine A2B receptor signaling contributes to priapism through HIF-1alpha mediated reduction of PDE5 gene expression. FASEB Journal 2014; 28(--):2725-2735. >>> ; IV (jugular); Mice; catheter was heparinized 250 U/ml; jugular catheter only;.

14305 Miyamoto, K., Tsumuraya, T., Ohtaki, H., Dohi, K., Satoh, K., Xu, Z.F., Tanaka, S., Murai, N., Watanabe, J., Sugiyama, K., Aruga, T., Shioda, S., Shioda, S. PACAP38 Suppresses Cortical Damage in Mice with Traumatic Brain Injury by Enhancing Antioxidant Activity. Journal of Molecular Neuroscience 2014; 54(--):370-379. >>> PACAP38; Saline; BSA; IV (femoral); Mice; Controls received mp w/ vehicle; animal info (male, C57BL6J, 10-12 weeks old, 21-26g); 0.1% BSA used; ischemia (cerebral); cardiovascular; peptides; used PE-10;.

14253 Lana, D., Melani, A., Pugliese, A.M., Cipriani, S., Nosi, D., Pedata, F., Giovannini, M.G., Giovannini, M.G. The neuron-astrocyte-microglia triad in a rat model of chronic cerebral hypoperfusion: protective effect of dipyridamole. FRONTIERS IN AGING NEUROSCIENCE 2014; 6(--):U7-U23. >>> Dipyridamole; IV (jugular); Rat; 2001; Controls received mp w/ vehicle; animal info (male, Wistar, 3 months old, 300g); pumps removed after 7 days; used ALZET jugular catheter; pumps inclubated in 37C for 12 hours;.

14615 Velez, J.C.Q., Janech, M.G., Hicks, M.P., Morinelli, T.A., Rodgers, J., Self, S.E., Arthur, J.M., Fitzgibbon, W.R., Velez, J.C.Q. Lack of Renoprotective Effect of Chronic Intravenous Angiotensin-(1-7) or Angiotensin-(2-10) in a Rat Model of Focal Segmental Glomerulosclerosis. PLoS One 2014; 9(--):U305-U318. >>> Angiotensin II; angiotensin (2-10); angiotensin (1-7); Saline, isotonic; IV (jugular); Rat; 2004; 2006; Control animals received mp w/ vehicle; animal info (male, FHH, 95-205 g); peptides; blood pressure measured via tail cuff.

14609 Wang, X.W., Li, G.P., Li, G.P. Angiotensin-(1-7) Prevent Atrial Tachycardia Induced Sodium Channel Remodeling. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 2014; 37(--):1349-1356. >>> Angiotensin (1-7); IV (jugular); Dog (mongrel); Animal info (male, female, 11-15 kg); peptides.

14575 Wedel, J., Weij, M., Smit-van Oosten, A., Hillebrands, J.L., Hillebrands, J.L. Simultaneous subcutaneous implantation of two osmotic minipumps connected to a jugular vein catheter in the rat. Laboratory Animals 2014; 48(--):338-341. >>> Dopamine, N-octanoyl; Tween 80; saline; IV (jugular); Rat; 2ML4; animal info (male, Brown Norway, 230-270 g, female, Wistar, 280-310 g); good methods;"Our data show that double pump implantation is a feasible alternative to changing pumps or the use of extracorporeal pump systems connected via a long wire to partly restrained animals."pg 338; N-octanoyl-dopamine also known as NOD; multiple pumps (2) used; two pumps connected to Y connector, in-house made Y-tube;"we showed that the simultaneous implantation of two slow-flow rate osmotic pumps connected to a jugular vein catheter is feasible and is not linked to additional signs of discomfort compared with single pump-implanted rats."pg 341.

13886 Ocaranza, M.P., Moya, J., Barrientos, V., Alzamora, R., Hevia, D., Morales, C., Pinto, M., Escudero, N., Garcia, L., Novoa, U., Ayala, P., az-Araya, G., Godoy, I., Chiong, M., Lavandero, S., Jalil, J.E., Michea, L. Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis. Journal of Hypertension 2014; 32(-4-):771-783. >>> Angiotensin II; angiotensin (1-9); PD123319; A779; IV (jugular); Rat; 2002; Controls received mp w/ vehicle; animal info (male, Sprague Dawley); functionality of mp verified by plasma levels; pumps replaced every 14 days; cardiovascular; antihypertensive; peptides; bp measured using CODA 2;.

13853 Lyden, P., Pereira, B., Chen, B., Zhao, L.F., Lamb, J., Lei, I.F., Rajput, P. Direct Thrombin Inhibitor Argatroban Reduces Stroke Damage in 2 Different Models. Stroke 2014; 45(-3-):896-899. >>> Argatroban; Saline; IV; Rat; 2001D; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 290-310g); ischemia (cerebral); behavioral testing (morris water maze, barnes maze task, spatial probe task);.

13851 Loh, K.P., Ng, G., Yu, C.Y., Fhu, C., Yu, D.J., Vennekens, R., Nilius, B., Soong, T.W., Liao, P. TRPM4 inhibition promotes angiogenesis after ischemic stroke. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2014; 466(-3-):563-576. >>> RNA, small interfering TRPM inhibiting; IV (jugular); Rat; Controls received mp w/ vehicle; animal info (male, Wistar, 300g); ischemia (cerebral); behavioral testing (rotarod apparatus); gene therapy; cardiovascular; TRPM4 aka transient receptor potential melastatin 4;.

13830 Kim, D., Zai, L.L., Liang, P., Schaffling, C., Ahlborn, D., Benowitz, L.I. Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury. PLoS One 2013; 8(-12-):U1143-U1156. >>> Inosine; Saline; CSF/CNS; IV; Rat; 2002; 2ML1; Animal info (male, Sprague Dawley, adult, 250-300g); pumps replaced biweekly or weekly; ALZET brain infusion kit 2 used; dose-response (pg.8); spinal cord injury; post op. care (buprenex 0.05 mg/kg; enrofloxacin 2.5 mg/kg, bladders expressed manually BID, SC bolus of lactated Ringer's solution BID); behavioral testing (ladder rung waking; hindlimb function; open field behavior); pumps primed; IV catheters flushed weekly during pump change;.

13817 Jarvis, M.F., Scott, V.E., McGaraughty, S., Chu, K.L., Xu, J., Niforatos, W., Milicic, I., Joshi, S., Zhang, Q.W., Xia, Z.R., Jarvis, M.F. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochemical Pharmacology 2014; 89(--):536-544. >>> Vincristine sulfate; IV (jugular); Rat; 2002; Animal info (male, Sprague Dawley, 200-420g); behavioral testing (paw withdrawal); pumps primes overnight; used PE-60 catheter tubing; chemotherapy-induced neuropathic pain model;.

13803 Hecker, M., Ott, J., Sondermann, C., Schaefer, M.B., Obert, M., Hecker, A., Morty, R.E., Vadasz, I., Herold, S., Rosengarten, B., Witzenrath, M., Seeger, W., Mayer, K., Mayer, K. Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome. CRITICAL CARE 2014; 18(--):U648-U658Triglycerides, long-chain; triglycerides, medium chain; fish oil. >>> Triglycerides, long-chain; triglycerides, medium chain; fish oil; IV (jugular); Mice; Controls received mp w/ saline; animal info (BALB/c, 13-15 weeks old, 22-24g); functionality of mp verified by plasma concentration; pumps replaced every 7 days; immunology; mice injected with low dose unfractionated heparin SC;.

13619 Rau, T.F., Kothiwal, A.S., Rova, A.R., Brooks, D.M., Rhoderick, J.F., Poulsen, A.J., Hutchinson, J., Poulsen, D.J. Administration of low dose methamphetamine 12 h after a severe traumatic brain injury prevents neurological dysfunction and cognitive impairment in rats. Experimental Neurology 2014; 253(-;-):31-40. >>> Methamphetamine; IV (femoral); Rat; 2001D; Controls received mp w/ vehicle; animal info (male, Wistar, 350-500g); functionality of mp verified by plasma serum levels; dose-response (pg.33); behavioral testing (foot fault assessment, morris water maze); pumps implanted in inguinal crease; catheter preloaded with 50% dextrose/50% heparin; pumps removed after 61-65hours;.

13582 Yang, Y., Zhang, Y.G., Lin, G.A., Xie, H.Q., Pan, H.T., Huang, B.Q., Liu, J.D., Liu, H., Zhang, N., Li, L., Chen, J.H. Spinal Changes of a Newly Isolated Neuropeptide Endomorphin-2 Concomitant with Vincristine-Induced Allodynia. PLoS One 2014; 9(-2-):U627-U638. >>> Vincristine; IV (jugular); Rat; 2002; Control animals received mp w/ saline; animal info (adult, male, Sprague Dawley, 200 g).

13551 Muradov, J.M., Hagg, T. Intravenous Infusion of Magnesium Chloride Improves Epicenter Blood Flow during the Acute Stage of Contusive Spinal Cord Injury in Rats. Journal of Neurotrauma 2013; 30(-10-):840-852. >>> Magnesium chloride; PEG; IV (jugular); Rat; 2001D; 1003D; 2001; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, young adult, 180-220g); functionality of mp verified by residual volume; spinal cord injury; post op. care (Bacitracin ointment, saline injection SC, heating pad, twice daily bladder expression); behavioral testing (open field test, grid walk); Primed overnight in saline 37C.

13440 Takemori, K., Tahara, A., Murakami, T., Kometani, T. Effects of Oxidative Stress on Vascular Reactivity in the Offspring of Protein-Restricted Stroke-Prone Spontaneously Hypertensive Rats. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2013; 77(-8-):1689-1693Phorbol 12-myristate 13-acetate. >>> Phorbol 12-myristate 13-acetate; IV (femoral); Rat; 2ML4; Animal info (SHRSP(spontaneously hypertensive)/Kpo, 12 weeks old); no stress"There were no significant differences in either the body weight or blod pressure after starting PMA infusion"(see pg. 1691); phorbol 12-myristate 13-acetate aka PMA; PMA is an activator of NADPH oxidase; induces superoxide anion production.

13389 Ji, X.T., Qian, N.S., Zhang, T., Li, J.M., Li, X.K., Wang, P., Zhao, D.S., Huang, G., Zhang, L., Fei, Z., Jia, D., Niu, L. Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model. PLoS One 2013; 8(-4-):U440-U451. >>> Vincristine; Saline; IV (jugular); Rat; 2002; Controls received mp w/ vehicle; animal info (male, adult, sprague dawley, 200g); behavioral testing (Rotarod test, Von Frey monofilaments, Hargreaves'method);"Implantation of the mini-osmotic pump is a simple procedure with the advantages of performing only once, providing reliable intravenous drug delivery, taking little time to perform, and good tolerance"pg 9; Used to induce chemotherapy-induced neuropathic pain in rat model.

13339 Farhat, N., Thorin-Trescases, N., Mamarbachi, M., Villeneuve, L., Yu, C., Martel, C., Duquette, N., Gayda, M., Nigam, A., Juneau, M., Allen, B.G., Thorin, E. Angiopoietin-Like 2 Promotes Atherogenesis in Mice. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2013; 2(-3-):U137-U149. >>> Angiopoietin like -2; TBSE; IV; Mice (transgenic); 1004; Control animals received mp w/ vehicle; animal info (3 mo old, ATX).

13296 Nguyen, T.D., Shingu, Y., Amorim, P.A., Schwarzer, M., Doenst, T. Glucagon-like peptide-1 reduces contractile function and fails to boost glucose utilization in normal hearts in the presence of fatty acids. International Journal of Cardiology 2013; 168(-4-):4085-4092. >>> Glucagon-like peptide-1; Saline; IV (jugular vein); Rat; 2ML4; Cardiovascular; peptides; animal info (male, Sprague Dawley rats, 250-350g, 110-130g); functionality verified by residual volume; diabetes;.

13215 Tian, Y.F., He, C.T., Chen, Y.T., Hsieh, P.S. Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats. WORLD JOURNAL OF GASTROENTEROLOGY 2013; 19(-18-):2761-2771. >>> LPS; Saline; IV; Rat; 2004; Controls received mp w/ saline; toxicology; immunology; animal info (male, sprague-dawley, 5-6 weeks old); portal vein; mp were used to infuse LPS to study the effect of lipoic acid on suppressing steatohepatitis in portal endotoxemia;.

13198 Tosun, C., Kurland, D.B., Mehta, R., Castellani, R.J., deJong, J.L., Kwon, M.S., Woo, S.K., Gerzanich, V., Simard, J.M. Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage. Stroke 2013; 44(-12-):3522-3528. >>> Glibenclamide; oligonucleotide, antisense; DMSO; IV; Rat; 2001; Animal info (SAH model, Wistar, 300-350g); Sur1-Trpm4 channels are upgreulated in cortex adjaced to SAH which induces abnormal BBB permeability and neuroinflammation.

13195 Ding, G.L., Chopp, M., Poulsen, D.J., Li, L., Qu, C.S., Li, Q.J., Nejad-Davarani, S.P., Budaj, J.S., Wu, H.T., Mahmood, A., Jiang, Q. MRI of Neuronal Recovery after Low-Dose Methamphetamine Treatment of Traumatic Brain Injury in Rats. PLoS One 2013; 8(-4-):U175-U183. >>> Methamphetamine; IV; Rat; Controls received mp w/ saline; animal info. (male, wistar rats, 200-300 g); functionality of mp verified by MRI measurement of fractional anisotropy.

13193 Dane, M.J.C., van den Berg, B.M., Avramut, M.C., Faas, F.G.A., van der Vlag, J., Rops, A.L.W.M., Ravelli, R.B.G., Koster, B.J., van Zonneveld, A.J., Vink, H., Rabelink, T.J. Glomerular Endothelial Surface Layer Acts as a Barrier against Albumin Filtration. American Journal of Pathology 2013; 182(-5-):1532-1540. >>> Bovine testicular Hyaluronidase; Saline; IV; Mice; Controls received mp w/ heat inactivated hyaluronidase; peptides; animal info. (C57B1/6, 14 weeks).

13156 Baquedano, E., Chowen, J.A., Argente, J., Frago, L.M. Differential effects of GH and GH-releasing peptide-6 on astrocytes. Journal of Endocrinology 2013; 218(-3-):263-274. >>> Growth hormone; Saline; IV (jugular); Rat; 2001; Control animals received mp w/ vehicle; animal info (Wistar, male, 200-250 g).

12832 Unden, J., Sjoelund, C., Laensberg, J.K., Wieloch, T., Ruscher, K., Romner, B. Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat. BMC NEUROSCIENCE 2013; 14(-;-):U1-U8. >>> Erythropoietin; Saline; IV (jugular); Rat; 2001D; 1003D; Control animals received mp w/ vehicle; animal info (Wistar, male, 300-350 g); silastic tubing used.

12808 Yo, K., Yu, Y.M., Zhao, G.Z., Bonab, A.A., Aikawa, N., Tompkins, R.G., Fischman, A.J. Brown adipose tissue and its modulation by a mitochondria-targeted peptide in rat burn injury-induced hypermetabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013; 304(-4-):E331-E341. >>> SS31; Saline; IV (jugular); Rat; Control animals received mp w/ vehicle; animal info (Sprague Dawley, male, 16-19 wks old, 400-500 g); peptides; stability verified via stable isotope dilution method ("more than 7 days").

12780 Katz, M.S., Thatch, K.A., Schwartz, M.Z. Gene alterations and intestinal mucosal changes following growth factor and omega-3 exposure in a rat model of inflammatory bowel disease. Journal of Pediatric Surgery 2013; 48(-2-):345-352. >>> Hepatocyte growth factor; HCl, Tris-; PBS; IV (jugular); Rat; Control animals received mp w/ saline; animal info (adult, female, tg, HLA-B27).

 

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“We found recently that 21 d of treatment of rats with SSRIs, at clinically relevant and stable serum concentrations (achieved by the use of osmotic minipumps), caused robust downregulation of the SERT.”... “Studies on the effects of chronic antidepressants on the SERT have resulted in inconsistent reports (Owens and Nemeroff, 1998). Among the factors that may contribute to such inconsistency is the route of drug administration. In most studies of chronic administration of Ads to rats, the drugs are given intraperitoneally or subcutaneously, either once or twice daily. As rats metabolize these drugs more rapidly than humans, such dosage schedules can result in appreciable fluctuations in the serum concentration of drug throughout the day. For certain pharmacologic effects, sustained drug action may be needed” Benmansour et al. The Journal of Neuroscience 2002; 22(15):6766-6772.