References on the Intravenous Administration of Agents Using ALZET^® Osmotic Pumps

Q0728 Ebrahimian,T., Li,M.W., Lemarie,C.A., Simeone,S.M.C., Pagano,P.J., Gaestel,M., Paradis,P., Wassmann,S., Schiffrin,E.L. Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Angiotensin II-Induced Inflammation and Hypertension Regulation of Oxidative Stress. Hypertension 2011; 57(-2-):245-U220. >>> Angiotensin II; IV; Mice; 14 days; Animal info (14-17 wks old, male, Mk2 KO); peptides; blood pressure measured via radiotelemetry (PAC-10, DSI).

Q0932 Thaete,L.G., Neerhof,M.G. ENDOTHELIN AND BLOOD PRESSURE REGULATION IN THE FEMALE RAT: STUDIES INNORMAL PREGNANCY AND WITH NITRIC OXIDE SYNTHASE INHIBITION-INDUCEDHYPERTENSION. HYPERTENSION IN PREGNANCY 2011; 19(-2-):233-247. >>> A-127722; A-182086; A-192621; FR-139317; L-NAME; Ethyl alcohol; propylene glycol; NaOH; water; SC; IV (jugular); Rat (pregnant); rat; 7 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley); multiple pumps per animal (2); wound clips used; 20% ethyl alcohol used; "It is likely that administration with the pumps resulted in more consistent drug levels..." pg 242.

P9964 Bi,M.H., Ott,J., Fischer,T., Hecker,M., Dietrich,H., Schaefer,M.B., Markart,P., Wang,B.E., Seeger,W., Mayer,K. INDUCTION OF LYMPHOCYTE APOPTOSIS IN A MURINE MODEL OF ACUTE LUNG INJURY-MODULATION BY LIPID EMULSIONS. SHOCK 2010; 33(-2-):179-188. >>> Soybean oil emulsion; olive oil emulsion; IV (jugular); Mice; ; Controls received mp w/ saline; animal info (male, BALB/c, 10-16 wks old, 22-25 g); external pump application.

P9920 Bott,R.C., Ashley,R.L., Henkes,L.E., Antoniazzi,A.Q., Bruemmer,J.E., Niswender,G.D., Bazer,F.W., Spencer,T.E., Smirnova,N.P., Anthony,R.V., Hansen,T.R. Uterine Vein Infusion of Interferon Tau (IFNT) Extends Luteal Life Span in Ewes. Biology of Reproduction 2010; 82(-4-):725-735. >>> Interferon-tau, recomb, ovine; IV (uterine vein); Sheep (ewe); 2001D; 2ML1; 7 days; 24 hours; Controls recieved mp w/BSA or sham surgeries; animal info (white-faced, western range ewe); cyanoacrylate adhesive.

Q0123 Hunt,J., Cheng,A., Hoyles,A., Jervis,E., Morshead,C.M. Cyclosporin A Has Direct Effects on Adult Neural Precursor Cells. Journal of Neuroscience 2010; 30(-8-):2888-2896. >>> Cyclosporin A; IV; SC; Mice; 2002; 14 days; Controls received mp w/ saline; animal info (male, CD1, 6-8 weeks old, 25-30 g).

Q0589 Iwasa,T., Okamoto,I., Takezawa,K., Yamanaka,K., Nakahara,T., Kita,A., Koutoku,H., Sasamata,M., Hatashita,E., Yamada,Y., Kuwata,K., Fukuoka,M., Nakagawa,K. Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs. British Journal of Cancer 2010; 103(-1-):36-42. >>> YM-155; cisplatin; carboplatin; DMSO; IV; Mice (nude); 1007D; 7 days; Controls received mp w/ vehicle; animal info (male, nude, BALB/cAnNCrj-nu/nu, 5 weeks old); 0.1% DMSO used; cancer.

Q0019 Iwata,M., Inoue,S., Kawaguchi,M., Nakamura,M., Konishi,N., Furuya,H. Posttreatment but Not Pretreatment with Selective beta-Adrenoreceptor 1 Antagonists Provides Neuroprotection in the Hippocampus in Rats Subjected to Transient Forebrain Ischemia. Anesthesia and Analgesia 2010; 110(-4-):1126-1132. >>> Propanolol; esmolol; landiolol; Saline, physiological; IV (femoral); Rat; 2ML1; 5 days; Controls received mp w/vehicle; animal info (male, Sprague-Dawley, 270-330 g, BCAO); ischemia (cerebral); behavioral testing (motor function, prehensile traction test).

Q0949 Johnson,P.L., Truitt,W., Fitz,S.D., Minick,P.E., Dietrich,A., Sanghani,S., Traeskman-Bendz,L., Goddard,A.W., Brundin,L., Shekhar,A. A key role for orexin in panic anxiety. Nature Medicine 2010; 16(-1-):111-U149. >>> Allylglycine, L-; allylglycine, D-; sodium lactate; CSF/CNS (hypothalamus); IV; Rat; 5 days; 48 hours; Controls received mp w/ isotonic saline; animal info (adult, male, Sprague-Dawley, 300-350 g); enzyme inhibitor (glutamic acid decarboxylase); Plastics One cannula used.

Q0127 Kaimoto,T., Yasuda,O., Ohishi,M., Mogi,M., Takemura,Y., Suhara,T., Ogihara,T., Fukuo,K., Rakugi,H. Nifedipine Inhibits Vascular Smooth Muscle Cell Dedifferentiation via Downregulation of Akt Signaling. Hypertension 2010; 56(-2-):247-U133. >>> Nifedipine; Ethanol; IV (jugular); Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; cardiovascular; animal info (male, Sprague-Dawley, 12 weeks old, balloon injury model).

Q0402 Kozin,S.V., Kamoun,W.S., Huang,Y.H., Dawson,M.R., Jain,R.K., Duda,D.G. Recruitment of Myeloid but not Endothelial Precursor Cells Facilitates Tumor Regrowth after Local Irradiation. Cancer Research 2010; 70(-14-):5679-5685. >>> AMD3100; IV; Mice (nude); 2 weeks; Animal info (mice athymic NCr/Sed nude (nu/nu) mice, female syngeneic FVB).

Q0217 Lima,V.V., Giachini,F.R., Carneiro,F.S., Carneiro,Z.N., Saleh,M.A., Pollock,D.M., Fortes,Z.B., Carvalho,M.H.C., Ergul,A., Webb,R.C., Tostes,R.C. O-GlcNAcylation Contributes to Augmented Vascular Reactivity Induced by Endothelin 1. Hypertension 2010; 55(-1-):180-188. >>> Endothelin-1; Sodium chloride; IV (jugular); Rat; 14 days; Controls received mp w/ sodium chloride; animal info (male, Wistar, 8-10 wks old, 230-250 g.); 0.9% sodium chloride used.

Q0164 liu,T.T., Kao,C.C., Chung,C.F., Hsieh,P.S. Chronic Hepatic Inflammation Induced by Mild portal endotoxemia Is Not Associated with systemic insulin resistance in rats. J Med Sci 2010; 30(-1-):15-20. >>> Endotoxin, LPS; Saline; IV (portal vein); Rat; 1004; 4 weeks; Controls received mp w/ vehicle; animal info (250-300 g, Sprague Dawley, 5-6 wks old).

Q0770 Meuwese,M.C., Broekhuizen,L.N., Kuikhoven,M., Heeneman,S., Lutgens,E., Gijbels,M.J.J., Nieuwdorp,M., Peutz,C.J., Stroes,E.S.G., Vink,H., van den Berg,B.M. Endothelial Surface Layer Degradation by Chronic Hyaluronidase Infusion Induces Proteinuria in Apolipoprotein E-Deficient Mice. PLoS One 2010; 5(-11-):U104-U110. >>> Hyaluronidase, testicular; IV (jugular); Mice; 4 weeks; Controls received mp w/ heat-inactivated hyaluronidase; animal info (14 wks old, ApoE-/-, ); ALZET mouse jugular catheter used; pump infused at 0.25 ul/hr; "it cannot be excluded that hyaluronidase remains stable in the subcutaneous Alzet minipump, which may have resulted in an underestimation of the effect of hyaluronidase during the 4 week course of the experiment. " pg e14262.

Q0319 Nath,K.A., Hernandez,M.C., Croatt,A.J., Katusic,Z.S., Juncos,L.A. Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010; 299(-5-):R1183-R1191. >>> Angiotensin II; Saline; IV; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley); peptides; mean arterial pressure measured.

Q0925 Rudolph,V., Andrie,R.P., Rudolph,T.K., Friedrichs,K, Kline,A, Hirsch-Hoffmann,B, Schwoerer,A.P., Lau,D, Fu,X., Klingel,K., Sydow,K., Didie,M., Seniuk,A  Nature Medicine 2010; 16(-4-):470-474. >>> Angiotensin II; myeloperoxidase; Saline; SC; IV (jugular); Mice; 7, 14 days; Controls received mp w/ vehicle; animal info (male, C57BL/6J, Mpo -/-, 12-15 wks old); peptides.

Q0739 Saleh,M.A., Boesen,E.I., Pollock,J.S., Savin,V.J., Pollock,D.M. Endothelin-1 Increases Glomerular Permeability and Inflammation Independent of Blood Pressure in the Rat. Hypertension 2010; 56(-5-):942-U427. >>> Endothelin-1; Saline; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 225-250 g); peptides.

Q0100 Tateya,S., Tamori,Y., Kawaguchi,T., Kanda,H., Kasuga,M. An Increase in the Circulating Concentration of Monocyte Chemoattractant Protein-1 Elicits Systemic Insulin Resistance Irrespective of Adipose Tissue Inflammation in Mice. Endocrinology 2010; 151(-3-):971-979. >>> MCP-1, recomb. mouse; PBS; BSA; SC; IV (jugular); Mice; 1002; 14 days; Controls received mp w/ saline; peptides; animal info (C57BL/6, 11 wks old).

P9895 Tran,L., Kompa,A.R., Kemp,W., Phrommintikul,A., Wang,B.H., Krum,H. Protective actions of estrogen on angiotensin. American Journal of Physiology-Heart and Circulatory Physiology 2010; 298(-2-):H608-H613. >>> Urotensin II, rat; Saline; IV (jugular); Rat; 2004; 28 days; Controls received mp w/vehicle, post op. care (buprenorphine); animal info (male, Sprague Dawley, 200-250 g).

Q0142 Zhang,Z.W., Yanamoto,H., Nagata,I., Miyamoto,S., Nakajo,Y., Xue,J.H., Iihara,K., Kikuchi,H. Platelet-Derived Growth Factor-Induced Severe and Chronic Vasoconstriction of Cerebral Arteries: Proposed Growth Factor Explanation of Cerebral Vasospasm. Neurosurgery 2010; 66(-4-):728-735. >>> Trapidil; Saline; IV (femoral); Rabbit; 2ML1; 48 hours; Controls received mp w/ vehicle; animal info (male, Japanese, white, 2.7-33 kg).

Q0602 Beauparlant,P., Bedard,D., Bernier,C., Chan,H., Gilbert,K., Goulet,D., Gratton,M.O., Lavoie,M., Roulston,A., Turcotte,E., Watson,M. Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anti-cancer Drugs 2009; 20(-5-):346-354. >>> GMX1777; NaCl; IV (jugular); Mice; 2001D; 24 hours; Controls received mp w/ vehicle; animal info (CB17, SCID/SCID, female); comparison of 72 h infusion pump vs 24 h mp; cancer (refractory solid tumors and lymphomas); "The 24 h infusion was the most effective administration schedule identified in mouse xenograft models" pg 352-353; cancer.

P9369 Belayev,L., Khoutorova,L., Zhao,K.L., Davidoff,A.W., Moore,A.F., Cramer,S.C. A novel neurotrophic therapeutic strategy for experimental stroke. Brain Research 2009; 1280(-;-):117-123. >>> Erythropoietin; Saline; IV (femoral); Rat; 2ML1; 3 days; Controls received mp w/ vehicle; animal info (male, Long-Evans, 280-330 g., MCAO).

P9484 Chen,Y.H., Oatway,M.A., Weaver,L.C. Blockade of the 5-HT3 Receptor for Days Causes Sustained Relief From Mechanical Allodynia Following Spinal Cord Injury. Journal of Neuroscience Research 2009; 87(-2-):418-424. >>> Ondansetron; Saline; IV (jugular); CSF/CNS (intrathecal); Rat; 1003D; 2001; 7 days, 72 hours; Controls received mp w/ vehicle; half life (p. 423) ~45 min; animal info (male, Wistar, 250-300 g.); pumps primed; spinal cord injury; ondansetron is a 5-HT3 receptor antagonist; Zofran.

P9742 Davies,J.S., Kotokorpi,P., Eccles,S.R., Barnes,S.K., Tokarczuk,P.F., Allen,S.K., Whitworth,H.S., Guschina,I.A., Evans,B.A.J., Mode,A., Zigman,J.M., Wells,T. Ghrelin Induces Abdominal Obesity Via GHS-R-Dependent Lipid Retention. MOLECULAR ENDOCRINOLOGY 2009; 23(-6-):914-924. >>> Ghrelin; BSA; heparin; IV (jugular); 2001; 14 days; Controls received mp w/vehicle; pumps replaced after 7 days; animal info (male, Sprague Dawley, 205-232 g).

P9671 Desbuards,N., Antier,D., Rochefort,G.Y., Apfeldorfer,C.S., Schenck,E., Hanton,G., Hyvelin,J.M. Dexfenfluramine discontinuous treatment does not worsen hypoxia-induced pulmonary vascular remodeling but activates RhoA/ROCK pathway: Consequences on pulmonary hypertension. European Journal of Pharmacology 2009; 602(-2-3-):355-363. >>> Dexfenfluramine; Water, sterile; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/ vehicle; animal info (female, Wistar, 250-275 g.).

P9824 Gerzanich,V., Woo,S.K., Vennekens,R., Tsymbalyuk,O., Ivanova,S., Ivanov,A., Geng,Z.H., Chen,Z., Nilius,B., Flockerzi,V., Freichel,M., Simard,J.M. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nature Medicine 2009; 15(-2-):185-191. >>> Oligonucleotide, antisense; IV (jugular); Rat; 24 hours; Controls received mp w/ sense; antisense (Trpm4); animal info (adult, female, Long Evans, 275-350 g); SCI; spinal cord injury.

Q0594 Granado,M., Chowen,J.A., Garcia-Caceres,C., gado-Rubin,A., Barrios,V., Castillero,E., Argente,J., Frago,L.M. Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2009; 309(-1-2-):67-75. >>> Ghrelin, n-octanoyl; IV (jugular); Rat; ; Controls received mp w/ saline; animal info (adult, male, Wistar, 250 g, STZ induced diabetes); infusion rate of 0.5 ul/hr.

Q0104 Hoksch,B., Rufer,B., Gazdhar,A., Bilici,M., Beshay,M., Gugger,M., Schmid,R.A. Taurolidine in the prevention and therapy of lung metastases. European Journal of Cardio-thoracic Surgery 2009; 36(-6-):1058-1063. >>> Taurolidine; IV; Rat; 7 days; Controls received tumorial implantation w/o mp; animal info (275-380 g, bdix); 2ML sized pump used.

R0252 Jacob,A., Wu,R.Q., Zhou,M., Wang,P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Research 2009; 2007(-89369-):-. >>> Curcumin; IV; Rat; 2ML1; 3 days; Immunology; phytochemical component in turmeric; antioxidant properties; anti-inflammatory.

P9418 Jernigan,N.L., Speed,J., LaMarca,B., Granger,J.P., Drummond,H.A. Angiotensin II Regulation of Renal Vascular ENaC Proteins. American Journal of Hypertension 2009; 22(-6-):593-597. >>> Angiotensin II; Saline; IV; Rat; 2002; 1 week; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (male, Sprague Dawley, 275-375 g.); nephrology.

P9640 Kang,Y.M., Ma,Y., Zheng,J.P., Elks,C., Sriramula,S., Yang,Z.M., Francis,J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research 2009; 82(-3-):503-512. >>> Angiotensin II; losartan; pyrrolidine dithiocarbamate; tempol; Saline; CSF, artificial; IV (femoral); CSF/CNS; Rat; 4 weeks; Controls received mp w/vehicle; peptides; multiple pumps per animal (2); animal info (adult, male, Sprague-Dawley, 275-300g); bilateral cannula used for multiple drug infusions.

Q0046 Kemp,W., Kompa,A., Phrommintikul,A., Herath,C., Jia,Z.Y., Angus,P., McLean,C., Roberts,S., Krum,H. Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 2009; 297(-4-):G762-G767. >>> Urotensin II, rat, 125I; Saline; IV (jugular); Rat; 2004; 28 days; Controls received mp w/ vehicle; peptides; cardiovascular; no stress (see pg. G763); animal info (male, Sprague-Dawley, 200-250 g); post op. care (buprenorphine); dose-response Fig. 1; hepatology.

P9375 Kennett,J.E., Poletini,M.O., Fitch,C.A., Freeman,M.E. Antagonism of Oxytocin Prevents Suckling- and Estradiol-Induced, But Not Progesterone-Induced, Secretion of Prolactin. Endocrinology 2009; 150(-5-):2292-2299. >>> Oxytocin antagonist; Saline; IV (jugular); Rat; 2001D; ; Controls received mp w/ vehicle; animal info (female, Sprague Dawley, 60 days old, 250-300 g.).

Q0798 Miksa,M., Wu,R.Q., Dong,W.F., Komura,H., Amin,D., Ji,Y.X., Wang,Z.M., Wang,H.C., Ravikumar,T.S., Tracey,K.J., Wang,P. Immature Dendritic Cell-Derived Exosomes Rescue Septic Animals Via Milk Fat Globule Epidermal Growth Factor VIII. Journal of Immunology 2009; 183(-9-):5983-5990. >>> Epidermal growth factor VIII, milk fat globule, recomb. murine; IV (jugular); Rat; 2001D; 20 hours; Controls received mp w/ PBS; immunology; animal info (male, Sprague-Dawley).

P9935 Nesher,M., Dvela,M., Igbokwe,V.U., Rosen,H., Lichtstein,D. Physiological roles of endogenous ouabain in normal rats. American Journal of Physiology-Heart and Circulatory Physiology 2009; 297(-6-):H2026-H2034. >>> Antibody, antiouabain; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/rabbit immunoglobulin in circulation; animal info (male wistar, 150-175 g).

Q0364 Oslund,K.L., Hyde,D.M., Putney,L.F., Alfaro,M.F., Walby,W.F., Tyler,N.K., Schelegle,E.S. Activation of Calcitonin Gene-Related Peptide Receptor during Ozone Inhalation Contributes to Airway Epithelial Injury and Repair. Toxicologic Pathology 2009; 37(-6-):805-813. >>> Uridine, bromodeoxy; C-2806 8-37; NaOH; IV (jugular); SC; Rat; 2001D; ; Controls received mp w/ sterile saline; animal info (male, Wistar, 200-250 g); peptide; multiple pumps per animal (2); C-2806 8-37 is a CGRP receptor antagonist; wound clips used; labeling of airway epithelium.

P9819 Savai,R., Langheinrich,A.C., Schermuly,R.T., Pullamsetti,S.S., Dumitrascu,R., Traupe,H., Rau,W.S., Seeger,W., Grimminger,F., Banat,A. Evaluation of Angiogenesis Using Micro-Computed Tomography in a Xenograft Mouse Model of Lung Cancer. NEOPLASIA 2009; 11(-1-):48-56. >>> Bevacizumab; IV (jugular); Mice (nude); 2002; 14 days; Controls received mp w/ distilled water; animal info (female, C57BL/6, 5-7 wks old, BALB/c, nu/nu, 7-8 wks old); pump implated IP; bevacizumab is a anti-VEGF antibody; "This delivery (using ALZET pumps) mimics local delivery of antivascular agents and can be used effectively alone or in combination with cytotoxic chemotherapy for site-specific drug delivery for lung cancer treatment. As expected, continuous infusion of bevacizumab decreased lung tumor volume and tumor perfusion, with an added survival advantage compared to the untreated group." pg 55; cancer (lung); antibody.

Q0156 Shah,K.G., Wu,R.Q., Jacob,A., Blau,S.A., Ji,Y.X., Dong,W.F., Marini,C.P., Ravikumar,T.S., Coppa,G.F., Wang,P. Human Ghrelin Ameliorates Organ Injury and Improves Survival after Radiation Injury Combined with Severe Sepsis. MOLECULAR MEDICINE 2009; 15(-11-12-):407-414. >>> Ghrelin, human; Saline; IV; Rat; 68 hours; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 250-300 g.).

P9852 Simcock,J.W., Penington,A.J., Morrison,W.A., Thompson,E.W., Mitchell,G.M. Endothelial Precursor Cells Home to a Vascularized Tissue Engineering Chamber by Application of the Angiogenic Chemokine CXCL12. Tissue Engineering Part A 2009; 15(-3-):655-664. >>> CXCL12; stromal cell-derived factor-1a, recomb. human; BSA; IV (arteriorvenous loop); Rat (nude); 1007D; 7 days; Functionality of mp verified; animal info (CBH/R nu/nu, 200-250 g.); diagram illustrating relationship of pump to chamber construct, fig. 1.

Q0678 Thatch,K.A., Mendelson,K.G., Haber,M.M., Schwartz,M.Z. Growth Factor Manipulation of Intestinal Angiogenesis: A Possible New Paradigm in the Management of Inflammatory Bowel Disease. Journal of Surgical Research 2009; 156(-2-):245-249. >>> Hepatocyte growth factor, recomb. human; HCl, Tris; PBS; IV (jugular); Rat; 1002; 14 days; Controls received mp w/ saline; animal info (female, adult, Fisher).

Q0526 Wu,R.Q., Dong,W.F., Qiang,X.L., Wang,H.C., Blau,S.A., Ravikumar,T.S., Wang,P. Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Critical Care Medicine 2009; 37(-8-):2421-2426. >>> Ghrelin, rat; Saline; IV (jugular); Rat; 2001D; 15 hours; Controls received mp w/ vehicle; animal info (male, Sprague Dawley, 275-325 g).

P9168 Bao,F., Chen,Y.H., Schneider,K.A., Weaver,L.C. An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury. Experimental Neurology 2008; 214(-2-):160-167. >>> BIO5192; Tris lactose; IV (jugular); Rat; 2001D; 1 day; Controls received mp w/ vehicle; animal info (male, female, Wistar, 200-220 g.); incorrectly stated 1003D pump has 200 ul reservoir; pumps were primed in 37 degree Celsius saline for 4 hours; BIO5192 is an alpha4beta1 inhibitor; spinal cord injury; PE10 connected to silastic medical grade tubing.

Q0037 Clark,S.R., McMahon,C.J., Gueorguieva,I., Rowland,M., Scarth,S., Georgiou,R., Tyrrell,P.J., Hopkins,S.J., Rothwell,N.J. Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. Journal of Cerebral Blood Flow and Metabolism 2008; 28(-2-):387-394. >>> Interleukin-1 receptor antagonist, recomb. met human; IV (jugular); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, MCAO); ischemia (cerebral); functionality of mp verified by CSF and plasma IL-1RA levels.

P8769 Joyner,J., Neves,L.A.A., Stovall,K., Ferrario,C.M., Brosnihan,K.B. Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-3-):R1073-R1080. >>> A-779; IV (jugular); Rat; rat (pregnant); 2ML2; 8 days; Controls received mp w/ vehicle; no stress (see pg. R1075); animal info (female, Sprague Dawley, 12-14 wks old, 230-330g.); A-779 is also known as D-alanine-Angiotensin-(1-7); A-779 is an angiotensin-(1-7) antagonist.

P9147 Kubota,T., Inoue,Y., Iwai,T., Kurihara,N., Huang,Y., Umeda,M. Arterial thrombosis after intravenous infusion of oral bacterium in a rat model. Annals of Vascular Surgery 2008; 22(-3-):412-416. >>> Bacteria, porphyromonas gingivalis; Culture, pure; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ saline; animal info (male, Wistar, 9-10 wks old, 200-300 g.); ATCC 33277 strain of porphyromonas gingivalis used; porphyromonas gingivalis is an oral bacterium.

P9877 Li,X., Liu,K.L., Zheng,J.Q., Chi,M.G., Dong,J.J., Dong,S.J., Gong,Z.H. Pharmacological characterization of 3-azabicyclo[3,2,1]octane-1-yl-L-leucyl-D-tryptophanyl-D-4-Cl- phenylalanine: A novel ETA receptor-selective antagonist. Pulmonary Pharmacology&Therapeutics 2008; 21(-5-):780-787. >>> ETP-508; DMSO; IV (jugular); Rat; 2ML2; 2ML4; 2, 4 weeks; Controls received mp w/ vehicle; animal info (male, Wistar, 280-320 g.); 10% DMSO used; EFP-508 is an endothelin A receptor antagonist.

Q0749 Minnaard-Huiban,M., Hermans,J.J.R., van Essen,H., Bitsch,N., Smits,J.F.M. Comparison of the effects of intrapericardial and intravenous aldosterone infusions on left ventricular fibrosis in rats. EUROPEAN JOURNAL OF HEART FAILURE 2008; 10(-12-):1166-1171. >>> Aldosterone; Polyethylene glycol; water; IV; intrapericardial; Rat; 2004; 8 weeks; Controls received mp w/ vehicle; long-term study; animal info (male, Wistar, 280-320 g); pumps replaced after 4 weeks.

P9280 Mitamura,T., Yamada,A., Hanaoka,K., Asano,M., Niwa,T., Seki,J. Effect of pharmacokinetic profile on the pancreatic toxicity and efficacy of tacrolimus in rats. JOURNAL OF TOXICOLOGICAL SCIENCES 2008; 33(-5-):575-584. >>> FK-506; Propylene glycol; ethanol; castor oil, hydrogenated; IV (femoral); Rat; 2002; 9, 14 days; Controls received mp w/ vehicle; functionality of mp verified by blood drug concentration; dose-response (fig. 4); comparison of bolus IV injections vs. mp; immunology; toxicology; animal info (male, Jcl:SD, 9 wks old: Fischer, WKAtt, 8 wks old; skin allograft); 15% EtOH used; "The sustained blood concentration of tacrolimus (via ALZET) with an AUC similar to that of bolus administration was better tolerated and had the same efficacy...These results indicate that the sustained-release formulation of tacrolimus has the potential to improve the safety of tacrolimus." (p. 583); also known as FK-506.

P8841 Mueller-Krebs,S., Kihm,L.P., Zeier,B., Gross,M.L., Deppisch,R., Wieslander,A., Henle,T., Penndorf,I., Oh,J., Reiser,J., Nawroth,P.P., Zeier,M., Schwenger,V. Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure. European Journal of Clinical Investigation 2008; 38(-5-):296-305. >>> Glucose degradation products; IV (jugular); Rat; 2ML4; 28 days; Controls received mp w/ saline; replacement therapy (5/6 nephrectomy); toxicology; animal info (male, Sprague Dawley, 230-270g.); nephrology.

P9047 Oslund,K.L., Hyde,D.M., Putney,L.F., Alfaro,M.F., Walby,W.F., Tyler,N.K., Schelegle,E.S. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. American Journal of Respiratory Cell and Molecular Biology 2008; 39(-3-):279-288. >>> SR140333; Uridine, bromodeoxy-; Saline, sterile; SC; IV (jugular); Rat; 2001D; 2ML2; ; Controls received mp w/ vehicle; good methods (pg. 280); animal info (male, Wistar); pumps were primed for 3 hours; polyethylene tubing used; incisions were closed with 7.5 mm steel wound clips.

P9795 Phongsisay,V., Susuki,K., Matsuno,K., Yamahashi,T., Okamoto,S., Funakoshi,K., Hirata,K., Shinoda,M., Yuki,N. Complement inhibitor prevents disruption of sodium channel clusters in a rabbit model of Guillain-Barre syndrome. Journal of Neuroimmunology 2008; 205(-1-2-):101-104. >>> Nafamostat mesilate; DMSO; IV (jugular); Rabbit; 2ML1; 7 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; enzyme inhibitor (serine protease); multiple pumps per animal (2); animal info (White); 50% DMSO used.

P9825 Rodriguez-Feo,J.A., Hellings,W.E., Moll,F.L., De Vries,J.P.P.M., van Middelaar,B.J., Algra,A., Sluijter,J., Velema,E., van der Broek,T., Sessa,W.C., De Kleijn,D.P.V., Pasterkamp,G. Caveolin-1 Influences Vascular Protease Activity and Is a Potential Stabilizing Factor in Human Atherosclerotic Disease. PLoS One 2008; 3(-7-):U567-U579. >>> Caveolin-1; caveolin-1, scrambled; DMSO; saline; IV (jugular); Mice; 2002; ; Peptides; animal info (BALB/C, Cav-1 null, wt); 30% DMSO used.

P9683 SHAO,Y., He,M., Zhou,L., Yao,T., Huang,Y., Lu,L.M. Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. Acta Pharmacologica Sinica 2008; 29(-7-):829-837. >>> Angiotensin (1-7); IV (jugular); 6 weeks; Animal info (4 months old, male, Sprague Dawley, 180-210 g.); long-term study.

P9202 Tejeda,M., Gaal,D., Hullan,L., Csuka,O., Schwab,R., Szokoloczi,O., Keri,G.Y. Continuous Administration of the Somatostatin Structural Derivative /TT-232/ by Subcutaneously Implanted Osmotic Pump Improves the Efficacy and Potency of Antitumor Therapy in Different Mouse and Human Tumor Models. Anticancer Research 2008; 28(-5A-):2769-2774. >>> TT-232; Water, distilled; acetic acid; sodium acetate; mannitol; SC; IV (jugular); Mice; 2001; 2002; 7; 14; 28 days; Comparison of IP and SC injections vs. SC and IV mp; pumps replaced after 2 weeks; PE-10 tubing used; "The frequent and long-lasting repetition of TT-232 injection enhanced its therapeutic efficacy; however, serial injection causes significant stress to animals and adequate precautions are required. To this end, an ALZET osmotic minipump inserted s.c. and i.v. was used." pg 2773; "The results obtained from this study suggest that TT-232 is a good candidate for delivery by continuous (infusion) therapy; cancer.

P9520 Thatch,K.A., Schwartz,M.Z., Yoo,E.Y., Mendelson,K.G., Duke,D.S. Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease. Journal of Pediatric Surgery 2008; 43(-12-):2169-2173. >>> Epidermal growth factor, recomb. human; human growth factor, recomb. human; IV; Rat; 7 days; Controls received mp w/ PBS; animal info (female, adult, Sprague Dawley, 200-250 g.).

P8758 Warne,J.P., Foster,M.T., Horneman,H.F., Pecoraro,N.C., de Jong,H.K., Ginsberg,A.B., Akana,S.F., Dallman,M.F. The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008; 294(-1-):E190-E200. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced Diabetes, gastroduodenal branch vagotomy).

P8584 Boesen,E.I., Anderson,W.P., Kett,M.M. Acute pressure-natriuresis relationship following withdrawal of chronic noradrenaline infusion. Clin Exp.Pharmacol.Physiol 2007/9; 34(-9-):881-883. >>> Noradrenalin; Ascorbic acid; NaH2 P04; saline, heparinized; IV (vena cava); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; cardiovascular; animal info (male, Sprague-Dawley, adult).

P8641 Chou,Y., Tsai,C.H., Ueng,K.C., Tian,T.Y., Chen,S.C., Yeh,H.I. Endothelial gap junctions are down-regulated by arsenic trioxide. European Journal of Pharmacology 2007; 569(-1-2-):29-36. >>> Arsenic trioxide; IV; Rat; 2ML4; 4 weeks; Controls received mp w/ saline; cardiovascular; animal info (male, Sprague-Dawley, 8 wks old).

P8116 Goldman,J., Zhong,L., Liu,S.Q. Negative regulation of vascular smooth muscle cell migration by blood shear stress. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-2-):H928-H938. >>> PD-98059; ML-7; IV (vena cava); Rat; 2ML1; 5, 7 days; Enzyme inhibitor (MAP kinase-ERK kinase 1/2, myosin light chain kinase); animal info (male, Sprague-Dawley, 30. old, vein grafts).

P8719 Hoeger,S., Gottmann,U., Liu,Z., Schnuelle,P., Birck,R., Braun,C., van der Woude,F.J., Yard,B.A. Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulation. TRANSPLANT INTERNATIONAL 2007; 20(-9-):790-799. >>> Dopamine; IV (femoral); Rat; 2ML1; 24 hours; Functionality of mp verified by blood pressure; animal info (male, Fisher, 200-250g).

P8612 Ito,N., Ohishi,M., Yamamoto,K., Tatara,Y., Shiota,A., Hayashi,N., Komai,N., Yanagitani,Y., Rakugi,H., Ogihara,T. Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats. Am.J.Hypertens. 2007/7; 20(-7-):792-799. >>> Temocaprilat; olmesartan; hydralazine; IV (vena cava); Rat; 2ML4; 4 weeks; Controls received mp w/ saline; enzyme inhibitor (ACE); cardiovascular; antihypertensive; animal info (male, SHR, 50 weeks old, male, Wistar-Kyoto, 10 weeks old).

P8611 Itoh,T., Obata,H., Murakami,S., Hamada,K., Kangawa,K., Kimura,H., Nagaya,N. Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. American Journal of Physiology- Lung Cellular and Molecular Physiology 2007; 293(-2-):L446-L452. >>> Adrenomedullin, recomb. human; Saline; IV (jugular); Rat; 2001D; 8,20 days; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; no stress (see pg. L447); peptides; animal info (male, Sprague-Dawley, 180-200 grams, LPS-induced lung injury); "The animals showed no signs of distress with this procedure." (p. L447).

P8521 LaMarca,B.D., Chandler,D.L., Grubbs,L., Bain,J., McLernore,GR Jr, Granger,J.P., Ryan,M.J. Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure. American Journal of Hypertension 2007; 20(-11-):1216-1221. >>> Tumor necrosis factor; Saline; heparin; IV; Rat; 2001; 5 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); cardiovascular; animal info (female, Sprague-Dawley, 15 weeks old).

P8730 McBryde,F.D., Guild,S.J., Barrett,C.J., Osborn,J.W., Malpas,S.C. Angiotensin II-based hypertension and the sympathetic nervous system: the role of dose and increased dietary salt in rabbits. Experimental Physiology 2007; 92(-5-):831-840. >>> Angiotensin II; IV (jugular); Rabbit; 2ML4; 3 weeks; Functionality of mp verified by mean arterial pressure; dose-response (fig. 1); cardiovascular; peptides; animal info (New Zealand White, 2.4-3.5 kg).

P8654 McKee,D.T., Poletini,M.O., Bertram,R., Freeman,M.E. Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats. Endocrinology 2007; 148(-10-):4649-4657. >>> Oxytocin antagonist; Saline, sterile; IV (jugular); Rat; 2001D; 24 hours; Controls received mp w/ vehicle; replacement therapy (ovariectomy); animal info (female, Sprague Dawley, 200-250g); endocrinology.

P8224 Menon,J., Soto-Pantoja,D.R., Callahan,M.F., Cline,J.M., Ferrario,C.M., Tallant,E.A., Gallagher,P.E. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Research 2007; 67(-6-):2809-2815. >>> Angiotensin (1-7); Saline; heparin; IV (jugular); Mice (nude); 2004; 28 days; Controls received mp w/ vehicle; no stress (see pg. 2810); cancer (lung); peptides; animal info (male, athymic, 2-4 weeks old, 15-20 grams); "During the infusion period, the animals maintained their body weight as well as food and water consumption and showed no evidence of reduced motor function. Additionally, no gross pathological abnormalities were observed in major organs..indicating a lack of toxic side effects." (p. 2810).

P8080 Nagano,H., Wei,P.Z., Wen,C.Q., Jomori,T., Oku,H., Ikeda,T., Saito,Y., Tano,Y. Effects of kallidinogenase on ischemic changes induced by repeated intravitreal injections of endothelin-1 in rabbit retina. Current Eye Research 2007; 32(-2-):113-122. >>> Kallidinogenase; Saline; IV (marginal ear vein); Rabbit; 4 weeks; Controls received mp w/ vehicle; ischemia (retinal); animal info (male, New Zealand, 2.5-3.5 kg.).

P8263 Nishimura,M., Takahashi,H., Yoshimura,M. Upregulation of the brain renin-angiotensin system in rats with chronic renal failure. ACTA PHYSIOLOGICA 2007; 189(-4-):369-377. >>> Candesartan; CSF, artificial; IV (jugular); CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle; replacement therapy (subtotal nephrectomy, dorsal rhizotomy); antihypertensive; cyanoacrylate adhesive; animal info (male, SHR/Izumo, 8 wks old, 300-350g.); ATI receptor antagonist.

P8639 Palaniyandi,S.S., Nagai,Y., Watanabe,K., Ma,M., Veeraveedu,P.T., Prakash,P., Kamal,F.A., Abe,Y., Yamaguchi,K., Tachikawa,H., Kodama,M., Aizawa,Y. Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats. EXPERIMENTAL BIOLOGY AND MEDICINE 2007; 232(-9-):1213-1221. >>> TY-51469; Phosphate buffer; NaOH; IV (jugular); Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; dose-response (fig. 2); stability verified by study in rat plasma at 40oC for 1 hour; enzyme inhibitor (chymase); cardiovascular; animal info (male, Lewis, 9 wks old).

P8643 Simard,J.M., Tsymbalyuk,O., Ivanov,A., Ivanova,S., Bhatta,S., Geng,Z.H., Woo,S.K., Gerzanich,V. Endothelial sulfonylurea receptor 1- regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. Journal of Clinical Investigation 2007; 117(-8-):2105-2113. >>> Glibenclamide; oligodeoxynucleotide, phosphorothioate missense; repaglinide; oligodeoxynucleotide, antisense; oligodeoxynucleotide, phosphorothioate antisense; oligodeoxynucleotide, missense; Saline; PBS; DMSO; SC; IV (jugular); CSF/CNS (parietal lobe); Rat; 2002; 1, 7, 10-14 days; Controls received mp w/ vehicle; antisense (Abcc8); ischemia (cerebral); animal info (female, Long-Evans, 275-350g, acute SCI); "We used constant infusion of a low dose of drug to achieve sustained occupancy of only high-affinity receptors." (p. 2109).

P8306 Tiranathanagul,K., Dhawan,V., Lytle,I.F., Zhang,W., Borschel,G.H., Buffington,D.A., Tziampazis,E., Brown,D.L., Humes,H.D. Tissue engineering of an implantable bioartificial hemofilter. ASAIO Journal 2007; 53(-2-):176-186. >>> Platelet-derived growth factor-BB; vascular endothelial growth factor 164; Saline, normal; albumin, rat serum; acetic acid; IA (femoral); IV (femoral); Rat; 2004; 28 days; Artificial kidney; controls received mp w/ vehicle; peptides; animal info (male, Fisher 344); mp attached by cannula to bioartificial hemofilter device, which surrounded and delivered agent to the femoral vessels; nephrology.

P8650 Usatii,M., Rousseau,L., Demers,C., Petit,J.L., Brossard,J.H., Gascon-Barre,M., Lavigne,J.R., Zahradnik,R.J., Nemeth,E.F., D'Amour,P. Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis. Kidney International 2007; 72(-11-):1330-1335. >>> Parathyroid hormone, human 1-34; parathyroid hormone, human 1-84; parathyroid hormone, rat 1-34; parathyroid hormone, rat 1-84; parathyroid hormone, rat 7-84; parathyroid hormone, rat 39-84; Saline; cysteine HCl, L-; IV (jugular); Rat; 1003D; 48 hours; Controls received mp w/ vehicle; replacement therapy (parathyroidectomy); peptides; animal info (male, Sprague-Dawley, 125-150g).

P8701 Warne,J.P., Horneman,H.F., Ginsberg,A.B., Pecoraro,N.C., Foster,M.T., Akana,S.F., Dallman,M.F. Mapping brain c-fos immunoreactivity after insulin-induced voluntary lard intake: Insulin- and lard-associated patterns. Journal of Neuroendocrinology 2007; 19(-10-):794-808. >>> Insulin, Humulin R U500; Saline; IV (jugular); Rat; 2002; 10 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced diabetes); no stress (see pg. 797); peptides; post op. care (Ketoprofen); animal info (male, Sprague-Dawley, 300g); "The presence of an osmotic mini-pump at either site did not cause any obvious signs of pains or discomfort in the rats. " (p. 797).

P8620 Warne,J.P., Foster,M.T., Horneman,H.E., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats. JOURNAL OF PHYSIOLOGY-LONDON 2007; 583(-2-):455-467. >>> Insulin, Humulin R U500; IV (superior mesenteric); Rat; 2002; 10 days; Controls received mp w/ saline; replacement therapy (STZ-induced diabetes); peptides; animal info (male, Sprague-Dawley, 300 g); catheter position verified.

P8479 Whalen,E.J., Foster,M.W., Matsumoto,A., Ozawa,K., Violin,J.D., Que,L.G., Nelson,C.D., Benhar,M., Keys,J.R., Rockman,H.A., Koch,W.J., Daaka,Y., Lefkowitz,R.J., Stamler,J.S. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 2007; 129(-3-):511-522. >>> Isoproterenol; GSNO; PBS; IV (jugular); Mice; ; Cardiovascular; agent is also known as nitrosoglutathione.

P8993 Wu,R.Q., Dong,W.F., Cui,X.X., Zhou,M., Simms,H.H., Ravikumar,T.S., Wang,P. Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Annals of Surgery 2007; 245(-3-):480-486. >>> Ghrelin, rat; Saline, normal; IV (jugular); Rat; 2001D; 15 hours; Controls received mp w/ vehicle; half-life (p. 485) 11-17 minutes (rat); peptides; animal info (male, Sprague Dawley, 275-325 g.); Sepsis by cecal ligation and puncture; vagotomy; "ghrelin's half-life is 11 minutes in the normal rat and 17 minutes at the late stage of sepsis. Therefore, a continuous infusion of ghrelin is required to maintain its effective concentration in the circulation." (p. 485).

P8674 Yang,J., Dhawan,V., Morrish,D.W., Kaufman,S. Bimodal effects of chronically administered neurokinin B (NKB) on in vivo and in vitro cardiovascular responses in female rats. REGULATORY PEPTIDES 2007; 143(-1-3-):136-142. >>> Neurokinin B; DMSO; water; IV (inferior vena cava); Rat; 2001D; 2ML1; 5 days, 22 hours; Controls received mp w/ vehicle; functionality of mp verified by blood pressure; dose-response (p. 138); cardiovascular; peptides; multiple pumps per animal (3); animal info (female, Long Evans, 250-300g); neuropeptide; silastic cannula; telemetry implanted IP; 10% DMSO used; (3) 2001D pumps used to achieve a higher concentration for 22 hours.

P8164 Barchiesi,F., Jackson,E.K., Fingerle,J., Gillespie,D.G., Odermatt,B., Dubey,R.K. 2-methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle. Circulation Research 2006; 99(-3-):266-274. >>> Estradiol, 2-methoxy-; IV; Rat; 7, 8, 14, days; Controls received mp w/ vehicle; no stress (see pg. 269); cardiovascular; toxicology; animal info (male, Wistar Kyoto, 350-400 grams); balloon carotid artery injury, "treatment with 2-ME was not associated with any toxic adverse effects." (p. 269); estradiol metabolite.

P8163 Boodhwani,M., Mieno,S., Voisine,P., Feng,J., Sodha,N., Li,J., Sellke,F.W. High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine. Journal of Thoracic and Cardiovascular Surgery 2006; 132(-6-):1299-1306. >>> Vascular endothelial growth factor 165, recomb. human; Heparin; Perivascular (circumflex coronary artery); Mini-pig; 2ML4; 4 weeks; Cardiovascular; peptides; ischemia (cardiac); animal info (male, female, yucatan, 20-30 kg, 23 weeks old).

P8290 Brinkkoetter,P.T., Beck,G.C., Gottmann,U., Loesel,R., Schnetzke,U., Rudic,B., Hanusch,C., Rafat,N., Liu,Z.Z., Weiss,C., Leuvinik,H.G.D., Ploeg,R., Braun,C., Schnuelle,P., van der Woude,F.J., Yard,B.A. Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: Role of p42/p44 activation. Transplantation 2006; 82(-4-):534-542. >>> Dopamine; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ isotonic saline; ischemia; reperfusion injury; animal info (male, Lewis, 220-250 g).

P7840 Choi,J., Credit,K., Henderson,K., Deverkadra,R., He,Z., Wiig,H., Vanpelt,H., Flessner,M.F. Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration. Clinical Cancer Research 2006; 12(-6-):1906-1912. >>> Immunoglobulin G, donkey anti-rabbit; radio-isotopes; Kreb's solution; bicarbonate; ringer's solution; sodium azide; 125I tracer; IV (jugular); Rat (nude); 2001; 5-7 days; Cancer (metastatic ovarian carcinoma); animal info (RNU-nude, athymic, 150-180g.).

P8102 de Celix,A.D.R., Chowen,J.A., Argente,J., Frago,L.M. Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. Journal of Neurochemistry 2006; 99(-3-):839-849. >>> Growth hormone releasing peptide-6; Saline; IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Wistar, 200-250g.).

P8089 Gebhard,C., Petroktistis,F., Zhang,H., Kammerer,D., Koehle,C., Klingel,K., Albinus,M., Gleiter,C.H., Osswald,H., Grenz,A. Role of renal nerves and salt intake on erythropoietin secretion in rats following carbon monoxide exposure. Journal of Pharmacology and Experimental Therapeutics 2006; 319(-1-):111-116. >>> Isoproterenol; neuropeptide Y, [Leu31, Pro34]-; neuropeptide Y1 receptor antagonist; IV (jugular); Rat; 1003D; 16 hours; Controls received mp w/ vehicle; half-life (p.115) "short" for isoproterenol; peptides; animal info (male, Sprague-Dawley, 250-320g.).

P8148 Honore,P., Donnelly-Roberts,D., Namovic,M.T., Hsieh,G., Zhu,C.Z., Mikusa,J.P., Hernandez,G., Zhong,C.M., Gauvin,D.M., Chandran,P., Harris,R., Medrano,A.P., Carroll,W., Marsh,K., Sullivan,J.P., Faltynek,C.R., Jarvis,M.F. A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2- dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. Journal of Pharmacology and Experimental Therapeutics 2006; 319(-3-):1376-1385. >>> Vincristine sulfate; IV (jugular); Rat; 2002; 14 days; Animal info (male, Sprague-Dawley, 200-300g.); mp primed overnight; chemotherapy-induced neuropathic pain model.

P8087 Lefebvre,F., Prefontaine,A., Calderone,A., Caron,A., Jasmin,J.F., Villeneuve,L., Dupuis,J. Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure. Clinical Science 2006; 111(-3-):217-224. >>> Angiotensin II; IV (jugular); Rat; 28 days; Controls received sham surgery; functionality of mp verified by plasma Ang II levels; cardiovascular; peptides; animal info (male, Wistar, coronary artery ligation MI, 350-380g).

P7837 Martini,A.C., Fernandez-Fernandez,R., Tovar,S., Navarro,V.M., Vigo,E., Vazquez,M.J., Davies,J.S., Thompson,N.M., Aguilar,E., Pinilla,L., Wells,T., Dieguez,C., Tena-Sempere,M. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 2006; 147(-5-):2374-2382. >>> Ghrelin, rat; ghrelin, des-octanoyl; L163, 255; Saline, sterile; heparin; BSA; IV (jugalar); Rat; 2001; 7 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, 12 wk. old); L163, 255 is GHS-R1a-specific agonist.

P7871 Ohtaki,H., Nakamachi,T., Dohi,K., Aizawa,Y., Takaki,A., Hodoyama,K., Yofu,S., Hashimoto,H., Shintani,N., Baba,A., Kopf,M., Iwakura,Y., Matsuda,K., Arimura,A., Shioda,S. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2006; 103(-19-):7488-7493. >>> Pituitary adenylate cyclase-activating polypeptide, 6-38; pituitary adenylate cyclase-activating polypeptide 38; pituitary adenylate cyclase-activating polypeptide; Saline; BSA; IV (jugular); Mice; 4, 8 hours; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (BALB/C, IL-6 -/-, +/-, wt); partial or total middle cerebral artery occlusion.

P8278 Sakurai,S., Kojima,H., Uemura,M., Satoh,H., Fukui,H. Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats. WORLD JOURNAL OF GASTROENTEROLOGY 2006; 12(-13-):2095-2102. >>> Adrenomedullin, human; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ vehicle; comparison of IV injections vs. mp; cardiovascular; peptides; animal info (male, Sprague-Dawley, 150 grams); "Chronic infusion of AM (1.0 mg/h for 14 days) which keeps plasma human AM concentrations within the physiological limit reduced the vascular resistance and increased the blood flow in both of the systemic and splanchnic circulations." (p. 2100).

P8338 Schaefer,M.B., Ott,J., Mohr,A., Bi,M.H., Grosz,A., Weissmann,N., Ishii,S., Grimminger,F., Seeger,W., Mayer,K. Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury - Role of platelet-activating factor receptor. Critical Care Medicine 2006; 35(-2-):544-554. >>> Saline, physiological; lipoven; omegaven; IV (jugular); Mice; 10 days; Controls received mp w/ saline, physiological; pumps replaced after 7 days of saline infusion; animal info (BALB/C wt, 8-12 weeks old, 18-21 grams, LPS induced acute lung injury and IP inflammation); external pump application; lipoven 10% (soybean oil); omegaven 10% (fish oil); lipid emulsion.

P9203 Siddiqui,A.M., Cui,X.X., Wu,R.Q., Dong,W.F  Crit.Care Med. 2006; 34(-7-):1874-1882. >>> Curcumin; GW9662; DMSO; Dulbecco's modified eagle medium; IV (jugular); Rat; 2ML1; 3 days; Controls received mp w/vehicle; immunology; animal info (male, Sprague-Dawley; 275-325 g); phytochemical derived from the root Curcuma Conga (ginger family); 50% DMSO/ 50% DMEM; GW9662 via same pump; no apparent toxicity to DMSO observed; Curcumin administered IV due to low circulating plasma levels following gavage or gastric pump.

P7746 Soucy,N.V., Riley,J.P., Templin,M.V., Geary,R., de Peyster,A., Levin,A.A. Maternal and fetal distribution of a phosphorothioate oligonucleotide in rats after intravenous infusion. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 2006; 77(-1-):22-28. >>> Oligodeoxynucleotide, phosphorothioate antisense; PBS; IV (jugular); Rat (pregnant); 2ML1; 7 days; Comparison of 3 hr. IV infusion vs. mp; no stress (see pg. 23); half-life (p. 25) 60 min.; antisense HPV; animal info (female, Sprague-Dawley, 318g, GD12-GD19); mp primed 6 hr. in sterile saline.

P9504 Takagi,I  J Cardiovasc.Pharmacol 2006; 48(-5-):223-230. >>> Colforsin; isoproterenol; IV (jugular); Rabbit; 2ML2; 2 weeks; Controls received mp w/ saline; functionality of mp verified by plasma colforsin levels; no stress (see pg. 225); cardiovascular; animal info (female, Japanes, white, 3.7 kg).

P7654 Timmapuri,S.J., Otterburn,D.M., Arafat,H., Schwartz,M.Z. Hepatocyte growth factor increases glucagon immunoreactivity in jejunal cells during intestinal adaptation. Journal of Pediatric Surgery 2006; 41(-1-):150-153. >>> Hepatocyte growth factor; IV (jugular); Rat; 2002; 14 days; Controls received mp w/ saline; animal info (male, Sprague-Dawley, adult, 200-225 g); PE catheter used.

P7985 Warne,J.P., Horneman,H.F., Wick,E.C., Bhargava,A., Pecoraro,N.C., Ginsberg,A.B., Akana,S.F., Dallman,M.F. Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores. Endocrinology 2006; 147(-11-):5443-5451. >>> Insulin, methylene blue; Saline; IV (jugular); Rat; 2002; ; Functionality of mp verified by dye infusion; replacement therapy (diabetic); no stress (see pg. 5444); good methods; peptides; animal info (male, Sprague-Dawley, 275 grams); diabetes; PE-60 fused to PE-5.

P8064 Zhang,B., Hata,R., Zhu,P.X., Sato,K., Wen,T.C., Yang,L.H., Fujita,H., Mitsuda,N., Tanaka,J., Samukawa,K., Maeda,N., Sakanaka,M. Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression. Journal of Cerebral Blood Flow and Metabolism 2006; 26(-5-):708-721. >>> Ginsenoside Rb1; Saline, isotonic; IV (femoral); CSF/CNS; Rat; gerbil; 2001; 2004; 4 weeks; 1, 7 days; Controls received mp w/ vehicle; dose-response (fig. 2); cardiovascular; ischemia (cerebral); animal info (SHR-SP, 16-18 wk old, 250-300g. MCAO; male, Mongolian Gerbil, 70-80g., 12 wk old, MCAO).