Recent References on Cell Proliferation Studies Using ALZET^® Osmotic Pumps

1. Thymidine (Studies From 1996-2008)

P7532 Helander,H.F., Li,H. Cell proliferation in the gastric epithelium of the ulcer rat. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2005; 40(-12-):1386-1393. >>> Thymidine; gastrin-17, synthetic rat; Saline; BSA; SC; Rat; 2ML1; 2ML2; 1, 2, 6, 13 days; Controls received mp w/ agent and no induced ulcer; functionality of mp verified by plasma gastrin levels; multiple pumps per animal (2); animal info (female, Sprague-Dawley, 200-250 g); therapeutic treatment (gastric ulcer); mp primed overnight in 37C saline.

P7500 Lotinun,S., Sibonga,J.D., Turner,R.T. Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts. Endocrinology 2005; 146(-9-):4074-4081. >>> Parathyroid hormone, human 1-34; thymidine, methyl -3H; Sodium chloride; HCl; serum, rat; ethanol; SC; Rat; 1, 2, 4 weeks; 1, 3, 5 days; Controls received mp w/ vehicle; functionality of mp verified by serum PTH; pumps replaced after 2 weeks; stability verified; peptides; multiple pumps per animal (2); animal info (female, Sprague-Dawley, 260 g); 2% ethanol.

P7340 Thompson,C.K., Brenowitz,E.A., Thompson,C.K. Seasonal change in neuron size and spacing but not neuronal recruitment in a basal ganglia nucleus in the avian song control system. Journal of Comparative Neurology 2005; 481(--):276-283. >>> Thymidine, [3H]; SC; Bird (song sparrow); 1007D; 7 days.

P6496 Helander,H.F., Poorkhalkali,N. Parietal cell density during gastric ulcer healing in the rat. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2004; 39(-1-):20-26. >>> Thymidine, (methyl-3H)-; gastrin-17, synthetic rat; Saline; BSA; SC; Rat; 2ML1; 2ML2; 1,2,6,13 days; Functionality of mp verified by gastrin plasma concentrations; multiple pumps per animal (2); mp primed overnight in saline @ 37 degrees Celsius.

P7703 Van Miller,J.P., Garman,R.H., Hermansky,S.J., Mirsalis,J.C., Frederick,C.B. Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate. Regul.Toxicol.Pharmacol. 2003/2; 37(-1-):54-65. >>> Uridine, bromodeoxy; thymidine, 3H methyl-; PBS, dulbecco's; IP; Mice; 1003D; 2001D; 24 hours; Animal info (male wistar).

P5684 Chouaf-Lakhdar,L., Fevre-Montange,M., Brisson,C., Strazielle,N., Gamrani,H., Didier-Bazes,M. Proliferative activity and nestin expression in periventricular cells of the adult rat brain. NeuroReport 2003; 14(-4-):633-636. >>> Uridine, bromodeoxy-; thymidine; Saline; NaOH (sodium hydroxide); Radio-Isotopes; 3H tracer; CSF/CNS; Rat; 1003D; 3 days; Brain tissue distribution.

P5644 Poorkhalkali,N., Helander,H.F. Cell kinetics of the oesophageal epithelium in the rat: Effects of hypergastrinaemia. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2003; 38(-1-):14-19. >>> Thymidine; 3H Tracer; Radio-isotopes; IP; Bird (chicken); 2001; 24 hrs; 6,9,15,17 days; Pumps replaced after 7 days.

P4369 Doetsch,F., Caille,I., Lim,D.A., Garcia-Verdugo,J.M., Alvarez-Buylla,A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999/6/11; 97(--):703-716. >>> Thymidine, [3H]-; Ara-C; Radio-isotopes; Saline; 3H Tracer; CSF/CNS; CSF/CNS (surface of brain); mice; 2002; 1007D; 6, 12 days; Ara-C is cytosine-b-D-arabinofuranoside; controls received mp with vehicle.

P4127 Kuntz,A.L., Oesterle,E.C. Transforming growth factor-a with insulin induces proliferation in rat utricular extrasensory epithelia. Otolaryngol Head Neck Surg 1998; 118(--):816-824. >>> Thymidine; Transforming growth factor-a; Insulin; 3H tracer; Radio-isotopes; ear (cochlea); rat; 1003D; 2001; 3,7 days; controls received mp w/vehicle; tissue perfusion (cochlea); agents infused singly or concomitantly in same pump; ALZET brain infusion kit 1 was modified for cochlear infusion; peptides.

P4099 Jansen,C., Ihse,I., Axelson,J. Epidermal growth factor induces increased mucosal thickness of the small intestine in mouse. Eur.Surg.Res. 1997; 29(--):447-454. >>> Epidermal growth factor; Thymidine; 3H tracer; Radio-isotopes; SC; IP; mice; 1003D; 2001; 1, 3, 7 days; peptides; recomb. human EGF used.

P3552 Ohlsson,B., Jansen,C., Ihse,I., Axelson,J. Epidermal growth factor induces cell proliferation in mouse pancreas and salivary glands. Pancreas 1997; 14(-1-):94-98. >>> Epidermal growth factor; Thymidine; 3H tracer; Radio-isotopes; SC; IP; mice; 2001; 1003D; 1, 3, 7 days; controls received no treatment; peptides; human recomb. EGF used; EGF&[3H]-thymidine given concomitantly.

P3860 Zhu,J., Zhang,L., Hanisch,U.K., Felgner,P.L., Reszka,R. A continuous intracerebral gene delivery system for in vivo liposome-mediated gene therapy. Gene Therapy 1996; 3(--):472-476. >>> Liposomes; Gene, herpes simplex virus thymidine kinase; Gene, lacZ; CSF/CNS (caudate nucleus); Rat; 1003D; 3 days; controls received mp w/LacZ gene; tissue perfusion (tumor); functionality of mp verified by gene expression; comparison of intracerebral injections vs. mp; no stress (see pg.473); stability verified by gene expression; ALZET brain infusion kit used; cancer; gene therapy; "DNA-liposome complexes were stable within minipumps at body temperature (37C) for 1-3 days." (pg.474); "continuous administration of DNA-liposome complexes did not result in significant in vivo toxicity." (pg.474).

P3505 Roberson,D.W., Kreig,C.S., Rubel,E.W. Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory epithelium. Auditory Neuroscience 1996; 2(--):195-205. >>> Thymidine; Radio-isotopes; 3H tracer; ear (cochlea); bird (chicken); 2002; 5,12 days; 26,30 hours; tissue perfusion (cochlea); ALZET brain infusion kit used.

P3380 Kinsella,T.J., Glennon,M.C., Kunugi,K.A., Linstrom,M.J. In vivo modulation of iododeoxyuridine metabolism and incorporation into cellular DNA by 5'-amino-5'-deoxythymidine in normal mouse tissues and two human colon cancer xenografts. Clin.Cancer Res. 1996; 2(--):981-989. >>> Uridine, iododeoxy-; Thymidine, 5'-amino-5'-deoxy-; NaOH; SC; mice (nude); 2001; 6 days; controls received mp w/NaOH; 6 day stability verified by uv spectrophotometry p.983; cancer; toxicology; 1-2 mps used per animal; agents given singly&together.

P3329 Monticello,T.M., Swenberg,J.A., Gross,E.A., Leininger,J.R., Kimbell,J.S., Seilkop,S., Starr,T.B., Gibson,J.E., Morgan,K.T. Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells. Cancer Res. 1996; 56(--):1012-1022. >>> Thymidine, methyl; 3H tracer; Radio-isotopes; SC; rat; 2ML1; 5 days; cancer.

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2. Uridine, Bromodeoxy- (Studies From 2005-2008)

P9128 Schmiedl,A., Lempa,T., Hoymann,H.G., Rittinghausen,S., Popa,D., Tschernig,T., Fehrenbach,H., Pabst,R., Hoeper,M.M., Hohlfeld,J.M. Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally. VIRCHOWS ARCHIV 2008; 452(-6-):675-688. >>> Uridine, bromodeoxy; SC; Rat; ; Animal info (male, Lewis, 195-230 g.); 2 ml pump used.

P9098 Ou,Y.C., Conolly,R.B., Thomas,R.S., Xu,Y., Andersen,M.E., Chubb,L.S., Pitot,H.C., Yang,R.S. A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res. 2001/3/1; 61(-5-):1879-1889. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 3 days; Animal info (male, Sprague Dawley, 30 days old); labeling of hepatocytes.

P9096 O'Connor,J.C., Davis,L.G., Frame,S.R., Cook,J.C. Evaluation of a Tier I screening battery for detecting endocrine-active compounds (EACs) using the positive controls testosterone, coumestrol, progesterone, and RU486. Toxicol.Sci. 2000/4; 54(-2-):338-354. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 5 days; Animal info (female, C57BL/6, 42 days old, ovariectomized); labeling of uterine stromal cell.

P9093 Wyde,M.E., Seely,J., Lucier,G.W., Walker,N.J. Toxicity of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in diethylnitrosamine-initiated ovariectomized rats implanted with subcutaneous 17 beta-estradiol pellets. Toxicol.Sci. 2000/4; 54(-2-):493-499. >>> Uridine, bromodeoxy-; Saline; Rat; 2ML1; 7 days; Animal info (female, Sprague Dawley, ovariectomized).

P9057 Masunaga,S., Sakurai,Y., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Nagasawa,H., Uto,Y., Hori,H., Ono,K. The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons. British Journal of Radiology 2006; 79(-948-):991-998. >>> Uridine, bromodeoxy-; tirapazamine; Saline; SC; Mice; 2001D; 5 days; 24 hours; Tissue perfusion (tumor); comparison of IP injections vs. mp; cancer; animal info (8-11 wks old, female, syngenic C3H, He); tirapazamine, also known as TP2, is a lead compound as a bioreactive hypoxic cytotoxin; labing of P cells; cancer.

P9047 Oslund,K.L., Hyde,D.M., Putney,L.F., Alfaro,M.F., Walby,W.F., Tyler,N.K., Schelegle,E.S. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. American Journal of Respiratory Cell and Molecular Biology 2008; 39(-3-):279-288. >>> SR140333; Uridine, bromodeoxy-; Saline, sterile; SC; IV (jugular); Rat; 2001D; 2ML2; ; Controls received mp w/ vehicle; good methods (pg. 280); animal info (male, Wistar); pumps were primed for 3 hours; polyethylene tubing used; incisions were closed with 7.5 mm steel wound clips.

P8983 Ott,T., Jokwitz,M., Lenhard,D., Romualdi,A., Dombrowski,F., Ittrich,C., Schwarz,M., Willecke,K. Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis. European Journal of Cell Biology 2006; 85(-8-):717-728. >>> Uridine, bromodeoxy-; Mice; 1003D; 3 days; Cancer (breast, liver); animal info (male, C57BL/6-129sv, wt, Cx32 -/-, Cx26, FL/FL, Cx26 FL/FL:AlfpCre); "BrdU was applied by osmotic pumps over a period of 3 days to avoid diurnal variation in proliferation." (p. 720).

P8982 Masunaga,S.I., Nagasawa,H., Sakurai,Y., Uto,Y., Hori,H., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Ono,K. The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy. International Journal of Hyperthermia 2006; 22(-4-):287-299. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old).

P8963 Sadeu,J.C., Adriaens,I., Cortvrindt,R., Smitz,J. Study of folliculogenesis in vivo in guinea pig. Theriogenology 2007; 68(-9-):1228-1239. >>> Uridine, bromodeoxy; Saline; SC; Guinea-pig; 2ML1; 1, 2 weeks; Animal info (female, Dunkin-Hartley, 560-750).

P8898 Maeshima,A., Sakurai,H., Nigam,S.K. Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. Journal of the American Society of Nephrology 2006; 17(-1-):188-198. >>> Uridine, bromodeoxy-; IP; Rat; 1 week; Animal info (male, Sprague Dawley, 7 wks old, 240 g.); ischemia (kidney); nephrology.

P8885 Tharappel,J.C., Spear,B.T., Glauert,H.P. Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-kappaB. TOXICOLOGY AND APPLIED PHARMACOLOGY 2008; 226(-3-):338-344. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 3 days; Animal info (7-8 wks old, B6129, p50 -/-).

P8868 Mziaut,H., Kersting,S., Knoch,K.P., Fan,W.H., Trajkovski,M., Erdmann,K., Bergert,H., Ehehalt,F., Saeger,H.D., Solimena,M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-2-):674-679. >>> Uridine, bromodeoxy-; DMSO; IP; Mice; 1007D; 7 days; Animal info (ICA 512 -/-); 50% DMSO used; diabetes.

P8813 Kubota,Y., Takubo,K., Suda,T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochemical and Biophysical Research Communications 2008; 366(-2-):335-339. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2004; 2 months; Long-term study; pumps replaced after 28 days; multiple pumps per animal (2); animal info (C57BL/6, 1 month old); labeling of bone marrow LRC's.

P8788 Ray,J.B., Arab,S., Deng,Y., Liu,P., Penn,L., Courtman,D.W., Ward,M.E. Oxygen regulation of arterial smooth muscle cell proliferation and survival. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H839-H852. >>> Uridine, bromodeoxy-; DMSO; SC; Rat; 2ML2; 48 hours; Animal info (male, Sprague Dawley, 175-200 g.); 0.4% DMSO used.

P8763 Lassmann,J., Sliwoski,J., Chang,A., Canning,D.A., Zderic,S.A. Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-1-):R58-R65. >>> Uridine, bromodeoxy-; Carbonate solution; SC; Mice; 2004; 4 weeks; Animal info (male, SERCA2, partial bladder outlet obstruction, 8 wks old).

P8729 Masunaga,S., Takahashi,A., Ohnishi,K., Nagata,K., Suzuki,M., Kashino,G., Kinashi,Y., Ohnishi,T., Ono,K. Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population. Oncology Reports 2007; 18(-6-):1589-1596. >>> Uridine, bromodeoxy-; Saline; SC; Mice (nude); 2001; 7 days; Tissue perfusion (tumor); cancer; animal info (Balb/cA, nude); labeling of tumor cells.

P8727 Hsieh,P.C.H., Segers,V.F.M., Davis,M.E., MacGillivray,C., Gannon,J., Molkentin,J.D., Robbins,J., Lee,R.T. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Medicine 2007; 13(-8-):970-974. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 7 days; Animal info (adult, transgenic, MerCreMer-ZEG); labeling of cardiomyocytes.

P8716 Bunaciu,R.P., Tharappel,J.C., Lehmler,H.J., Kania-Korwel,I., Robertson,L.W., Srinivasan,C., Spear,B.T., Glauert,H.P. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 2007; 239(-3-):147-155. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; ; Toxicology; animal info (female, Sprague-Dawley, 100-125g); labeling of hepatocytes.

P8691 Martin,C.D., Jimenez-Andrade,J.M., Ghilardi,J.R., Mantyh,P.W. Organization of a unique net-like meshwork of CGIZP+ sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain. Neuroscience Letters 2007; 427(-3-):148-152. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 24 hours; Animal info (C57BL/6J, 18-25g, male); bone; pain; labeling at the periosteum.

P8568 Ma,J., Matsusaka,T., Yang,H., Kawachi,H., Shimizu,F., Isaka,Y., Imai,E., Kon,V., Ichikawa,I. Local actions of endogenous angiotensin II in injured glomeruli. J.Am.Soc.Nephrol. 2004/5; 15(-5-):1268-1276. >>> Uridine, bromodeoxy-; SC; Rat; 1007D; 3 days; Animal info (male, Wistar, 140-160 grams); ischemia (renal artery); nephrology.

P8566 Virag,J.A.I., Rolle,M.L., Reece,J., Hardouin,S., Feigl,E.O., Murry,C.E. Fibroblast growth factor-2 regulates myocardial infarct repair - Effects on cell proliferation, scar contraction, and ventricular function. American Journal of Pathology 2007; 171(-5-):1431-1440. >>> Uridine, bromodeoxy-; DMSO; water; SC; Mice (knockout); 1007D; 4 days; Cardiovascular; animal info (FGF2 knockout mice, 6-8 weeks old, 20-30 grams); 50% DMSO 50% water; labeling of endothelial cells.

P8535 Gordon,S.E., Westerkamp,C.M., Savage,K.J., Hickner,R.C., George,S.C., Fick,C.A., McCormick,K.M. Basal, but not overload-induced, myonuclear addition is attenuated by NG-initro-L-arginine methyl ester (L-NAME) administration. Canadian Journal of Physiology and Pharmacology 2007; 85(-6-):646-651. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Animal info (female, Sprague-Dawley, 220 g).

P8522 Kim,I., Morimura,K., Shah,Y., Yang,Q., Ward,J.M., Gonzalez,F.J. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007; 28(-5-):940-946. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 1 week; Animal info (C57NL/6N, wt, Fxr-null; 3,12 months old).

P8502 Yang,Q., Ito,S., Gonzalez,F.J. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis 2007/6; 28(-6-):1171-1177. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2001; 1 week; labeling of hepatocytes; animal info (transgenic).

P8464 Zhao,M., Momma,S., Delfani,K., Carlen,M., Cassidy,R.M., Johansson,C.B., Brismar,H., Shupliakov,O., Frisen,J., Janson,A.M. Evidence for neurogenesis in the adult mammalian substantia nigra. Proc.Natl.Acad.Sci.U.S.A 2003/6/24; 100(-13-):7925-7930. >>> Uridine, bromodeoxy-; thymidine, 3H; Ara-C; Saline, radio-isotopes; CSF/CNS; IP; Mice; 1003D; 1002; 2004; 2,3,10,14,21 days; Comparison of oral administration vs. IP injections; animal info (male, C57BL/6, 2-20 months old); neurodegenerative (Parkinson's disease); "the blood brain barrier and or peripheral metabolism limit the availability of BrdUrd in the brain." (p. 7929).

P8348 Rudnick,D.A., Shikapwashya,O., Blomenkamp,K., Teckman,J.H. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology 2006; 44(-4-):976-982. >>> Uridine, bromodeoxy-; IP; Mice; 72 hours; Animal info (male, C57BL/6J-piz, 6-12 months old).

P8308 Price,R.J., Walters,D.G., Finch,J.M., Gabriel,K.L., Capen,C.C., Osimitz,T.G., Lake,B.G. A mode of action for induction of liver tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2007; 218(-2-):186-195. >>> Uridine, bromodeoxy-; Rat; 2ML1; 7 days; Cancer (liver); toxicology; animal info (male, female, Sprague-Dawley CD, 10-11 wks old); labeling of hepatocytes.

P8234 Keenan,K.P., Hoe,C.M., Mixson,L., McCoy,C.L., Coleman,J.B., Mattson,B.A., Ballam,G.A., Gumprecht,L.A., Soper,K.A. Diabesity: A polygenic model of dietary-induced obesity from ad libitum overfeeding of Sprague-Dawley rats and its modulation by moderate and marked dietary restriction. Toxicologic Pathology 2005; 33(-6-):650-674. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 7 days; Toxicology; animal info (male, female, Sprague-Dawley, 12, 25, or 52 weeks old).

P8221 Karas,R.H., Hodgin,J.B., Kwoun,M., Krege,J.H., Aronovitz,M., Mackey,W., Gustafsson,J.A., Korach,K.S., Smithies,O., Mendelsohn,M.E. Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc.Natl.Acad.Sci.U.S.A 1999/12/21; 96(-26-):15133-15136. >>> Uridine, bromodeoxy-; Mice; 14 days; Replacement therapy (ovariectomy); cardiovascular; animal info (female, 129XC57BL/6J, BERKO, unilateral carotid artery injury); labeling of endothelial cells.

P8209 Masunaga,S.I., Kasaoka,S., Maruyama,K., Nigg,D., Sakurai,Y., Nagata,K., Suzuki,M., Kinashi,Y., Maruhashi,A., Ono,K. The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2006; 66(-5-):1515-1522. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old, 20-25g.).

P8203 Masunaga,S., Nagasawa,H., Nagata,K., Suzuki,M., Uto,Y., Hori,H., Kinashi,Y., Ono,K. Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells. Journal of Cancer Research and Clinical Oncology 2007; 133(-1-):47-55. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5, 8 days; Cancer (carcinoma); animal info (female, 8-11 wks old).

P8169 Masunaga,S.I., Uto,Y., Nagasawa,H., Hori,H., Nagata,K., Suzuki,M., Kinashi,Y., Ono,K. Evaluation of hypoxic cell radio-sensitizers in terms of radio-sensitizing and repair-inhibiting potential. dependency on p53 status of tumor cells and the effects on intratumor quiescent cells. Anticancer Research 2006; 26(-2A-):1261-1270. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice (nude); 5, 7 days; Cancer (squamous cell carcinoma); animal info (BALB/cA, C3H/He, 6-7 weeks old, 22 grams); labeling of tumor 'P' cells.

P8135 Finch,J.M., Osimitz,T.G., Gabriel,K.L., Martin,T., Henderson,W.J., Capen,C.C., Butler,W.H., Lake,B.G. A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2006; 214(-3-):253-262. >>> Uridine, bromodeoxy-; 2ML1; 7, 14 days; Pumps replaced after 7 days; animal info (male, female, Sprague-Dawley CD, 10-11 wks old, 450-500g., 250-300g.).

P8099 Bernstein,D.M., Rogers,R., Smith,P., Chevalier,J. The toxicological response of Brazilian chrysotile asbestos: A multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response. INHALATION TOXICOLOGY 2006; 18(-5-):313-332. >>> Uridine, bromodeoxy-; SC; Rat; 2001; 3 days; Toxicology; animal info (male, Wistar Han-Ibm, 9 wk old).

P8095 Ohashi,K., Kay,M.A., Yokoyama,T., Kuge,H., Kanehiro,H., Hisanaga,M., Ko,S., Nakajima,Y. Stability and repeat regeneration potential of the engineered liver tissues under the kidney capsule in mice. CELL TRANSPLANTATION 2005; 14(-9-):621-627. >>> Uridine, bromodeoxy-; Mice; 2001; 2 weeks; Animal info (FVB/N, partial hepatectomy, hepatocyte transplantation); labeling of hepatocytes.

P8093 Kai,K., Yoshida,M., Sugawara,T., Kato,M., Uchida,K., Yamaguchi,R., Tateyama,S., Furuhuma,K. Investigation of initial changes in the mouse olfactory epithelium following a single intravenous injection of vincristine sulphate. Toxicologic Pathology 2005; 33(-7-):750-759. >>> Uridine, bromodeoxy-; SC; Mice; 2001D; 6, 24 hours; Animal Info (male, BALB/c, 8 wks. old); vincristine or unilateral bubectomy.

P8068 Cafaro,J., Lee,G.S., Stone,J.S. Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration. Developmental Dynamics 2007; 236(-1-):156-170. >>> Uridine, bromodeoxy-; PBS; Ear (perilymphatic fluid); Bird (chicken); 2002; 8 days; No stress (see p.167); Alzet brain infusion kit used; animal info (White Legorn, 5-10 days old).

P8065 Kronenberg,G., Wang,L.P., Synowitz,M., Gertz,K., Katchanov,J., Glass,R., Harms,C., Kempermann,G., Kettenmann,H., Endres,M. Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia. Journal of Cerebral Blood Flow and Metabolism 2005; 25(-12-):1613-1624. >>> Uridine, bromodeoxy-; SC; Mice; mice (transgenic); 4 days; Ischemia (cerebral); animal info (C57BL/6 nestin-GFP tg, 10-12 wk old, 20-25g, MCAO); "this dose is nontoxic and labels approximately 4 times more cells after cerebral ischemia than twice daily intraperitoneal injections" (p.1614).

P7991 Vogetseder,A., Palan,T., Bacic,D., Kaissling,B., Le Hir,M. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2007; 292(-2-):C807-C813. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 1, 2 weeks; Pumps replaced every 7 days for two week studies; animal info (male, Wistar, 4-5 weeks old, 110-140 grams); labeling of kidney.

P7930 Voss,K.A., Riley,R., Dunn,C., Corton,J.C. The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. Toxicology 2006; 222(-3-):165-174. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; animal info (male, 1.5 weeks old); labeling of hepatocytes.

P7887 Dedkov,E.I., Zheng,W., Tomanek,R.J. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. American Journal of Physiology-Heart and Circulatory Physiology 2006; 291(-4-):H1686-H1693. >>> Uridine, bromodeoxy-; Rat; 72 hours; Cardiovascular; animal info (male, Sprague-Dawley, 12 month old); left coronary artery ligation to induce MI; labeling of coronary arterioles (endothelial cells of the coronary arterioles).

P7801 Overstreet-Wadiche,L.S., Bromberg,D.A., Bensen,A.L., Westbrook,G.L. Seizures accelerate functional integration of adult-generated granule cells. Journal of Neuroscience 2006; 26(-15-):4095-4103. >>> Uridine, bromodeoxy-; Saline; NaOH; SC; Mice (transgenic); 2001D; 1 day; Animal info (adult, -13/+8POMC-EGFP Tg.); labeling of granule cells.

P7796 Martins,K.J.B., Gordon,T., Pette,D., Dixon,W.T., Foxcroft,G.R., MacLean,I.M., Putman,C.T. Effect of satellite cell ablation on low-frequency-stimulated fast-to-slow fibre-type transitions in rat skeletal muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 572(-1-):281-294. >>> Uridine, bromodeoxy-; SC; Rat; 2004; 21 days; Animal info (male, Wistar, 296g.); labeling of satellite cells.

P7794 Schrier,L., Ferns,S.P., Barnes,K.M., Emons,J.A.M., Newman,E.I., Nilsson,O., Baron,J. Depletion of resting zone chondrocytes during growth plate senescence. Journal of Endocrinology 2006; 189(-1-):27-36. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Rabbit; rabbit (pregnant); 2ML1; 1 week; Controls did not receive BrdU; animal info (New Zealand White, male; 5, 9&17 wk. old, female, pregnant); endocrinology; labeling of chondocytes.

P7786 Pauluhn,J., Mohr,U. Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose-only inhalation study in rats. Journal of Applied Toxicology 2006; 26(-3-):279-292. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 7 days; Animal info (male, Wistar, 5 months old); labeling of lung cells (alveolar, epithelial).

P7738 Hyatt,J.P.K., Roy,R.R., Baldwin,K.M., Wernig,A., Edgerton,V.R. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle&Nerve 2006; 33(-1-):49-60. >>> Uridine, bromodeoxy-; SC; Rat; 2ML2; 14 days; Animal info (female, Sprague-Dawley, 200-235g.; denervation or spinal cord isolation); labeling of satellite cells.

P7703 Van Miller,J.P., Garman,R.H., Hermansky,S.J., Mirsalis,J.C., Frederick,C.B. Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate. Regul.Toxicol.Pharmacol. 2003/2; 37(-1-):54-65. >>> Uridine, bromodeoxy-; thymidine, 3H methyl-; PBS, dulbecco's; IP; Mice; 1003D; 2001D; 24 hours; Animal info (male wistar).

P7671 Campbell,J.S., Riehle,K.J., Brooling,J.T., Bauer,R.L., Mitchell,C., Fausto,N. Proinflammatory cytokine production in. liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. Journal of Immunology 2006; 176(-4-):2522-2528. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 48 hours; Comparison of IP injection vs. mp; animal info (C57BL/6, KO, heterozygous, male, 11 wk old); labeling of hepatocytes.

P7630 Bauer,S., Patterson,P.H. The cell cycle-apoptosis connection revisited in the adult brain. Journal of Cell Biology 2005; 171(-4-):641-650. >>> Uridine, bromodeoxy-; Saline; CSF/CNS; Mice; 1003D; 24 hours; ALZET Brain Infusion Kit 2 used; animal info (2-4 month old, C57BL/6).

P7623 Ohyama,M., Terunuma,A., Tock,C.L., Radonovich,M.F., Pise-Masison,C.A., Hopping,S.B., Brady,J.N., Udey,M.C., Vogel,J.C. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. Journal of Clinical Investigation 2006; 116(-1-):249-260. >>> Uridine, bromodeoxy-; SC; Mice (nude); 1002; 4-6 weeks; Pumps replaced every 2 weeks; multiple pumps per animal (2).

P7593 Kaufmann,W., Mellert,W., van Ravenzwaay,B., Landsiedel,R., Poole,A. Effects of styrene and its metabolites on different lung compartments of the mouse - cell proliferation and histomorphology. Regulatory Toxicology and Pharmacology 2005; 42(-1-):24-36. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 2001; ; Cancer; toxicology; animal info (female, CD1, 49 days old); labeling of lung cells.

P7580 Poluektova,L., Meyer,V., Walters,L., Paez,X., Gendelman,H.E. Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis. Glia 2005; 52(-4-):344-353. >>> Uridine, bromodeoxy-; Saline, physiological; CSF/CNS; Mice (SCID); 2004; 7, 28 days; Animal info (SCID, 4 wk old, male).

P7510 Voss,K.A., Liu,J., Anderson,S.P., Dunn,C., Miller,J.D., Owen,J.R., Riley,R.T., Bacon,C.W., Corton,J.C. Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. TOXICOLOGICAL SCIENCES 2006; 89(-1-):108-119. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; No stress (see pg. 111); animal info (female, SV129, 20-22 g); labeling of hepatocytes.

P7459 Sales,V.L., Sukhova,G.K., Lopez-Ilasaca,Ma, Libby,P., Dzau,V.J., Pratt,R.E. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 2005; 112(-21-):3328-3336. >>> Uridine, bromodeoxy-; SC; IP; Mice; 2001; 7 days; Cardiovascular; animal info (male, C57 BL/6J, high cholesterol diet).

P7452 Elder,A., Gelein,R., Finkelstein,J.N., Driscoll,K.E., Harkema,J., Oberdoerster,G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. TOXICOLOGICAL SCIENCES 2005; 88(-2-):614-629. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 5 days; Animal info (female f-344 rat; female b6c3f1 mice; female 276f1b syrian golden hamster); labeling of lung cells.

P7444 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Noakes,J. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 1: Mode of action studies in the mouse. TOXICOLOGICAL SCIENCES 2005; 86(-1-):36-47. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Mice; 1003D; 3 days; Cancer (hepatic); toxicology; animal info (male, 30-43 g); labeling of hepatocytes.

P7441 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Peffer,R., Noakes,J., Robinson,M. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 2: Species differences in response. TOXICOLOGICAL SCIENCES 2005; 86(-1-):48-55. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 3 days; Cancer (hepatic); toxicology; animal info (female, 140-160 g).

P7409 Roy,S.K., Thilagar,A.K., Eastmond,D.A. Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2005; 586(-1-):28-37. >>> Uridine, bromodeoxy-; SC; Mice; 5 days; Labeling of hepatocytes; animal info (21 days old, CD-1, male).

P7408 Rissler,P., Soederdahl,G., Nordman,T., Xia,L., Torndal,U.B., Bjoernstedt,M., Ericzon,B.G., Olsson,J.M., Eriksson,L.C. Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation. TRANSPLANT INTERNATIONAL 2005; 18(-8-):992-1000. >>> Uridine, bromodeoxy-; NaOH; SC; Rat; ; Labeling of hepatocytes; animal info (male, wistar-kyoto, 4-5 weeks old, 110 g).

P7384 Currie,R.A., Bombail,V., Oliver,J.D., Moore,D.J., Lim,F.L., Gwilliam,V., Kimber,I., Chipman,K., Moggs,J.G., Orphanides,G. Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: Application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate. TOXICOLOGICAL SCIENCES 2005; 86(-2-):453-469. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 48,72 hours; Animal info (B6C3F1, male, 7-10 wks); labeling of hepatocytes.

P7368 Mohapel,P., Frielingsdorf,H., Haeggblad,J., Zachrisson,O., Brundin,P. Platelet-derived growth factor (PDGF-BB) and brainderived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience 2005; 132(-3-):767-776. >>> Platelet-derived growth factor-BB; brain-derived neurotrophic factor; uridine, bromodeoxy-; PBS; CSF/CNS; Rat; 2002; 10 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit used; neurodegenerative (parkinson's disease); labeling of striatum.

P7355 Smith,G.H. Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development 2005; 132(-4-):681-687. >>> Uridine, bromodeoxy-; Mice; 14 days; Labeling of mammary cells.

P7337 Yoon,Y.S., Wecker,A., Heyd,L., Park,J.S., Tkebuchava,T., Kusano,K., Hanley,A., Scadova,H., Qin,G.J., Cha,D.H., Johnson,K.L., Aikawa,R., Asahara,T., Losordo,D.W. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. Journal of Clinical Investigation 2005; 115(-2-):326-338. >>> Uridine, bromodeoxy-; DMSO; NaCl; SC; Rat (nude); 2ML4; 4 weeks; Ischemia (cardiac); Labeling of myocardial cells; 50% DMSO used.

P7326 Kishore,R., Qin,G.J., Luedemann,C., Bord,E., Hanley,A., Silver,M., Gavin,M., Goukassain,D., Losordo,D.W. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. Journal of Clinical Investigation 2005; 115(-7-):1785-1796. >>> Uridine, bromodeoxy-; Mice (nude); 7 days; Cardiovascular; ischemia (hindlimb); labeling of ischemic hind limb muscle.

P7311 Yang,P., Baker,K.A., Hagg,T. A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS. Journal of Comparative Neurology 2005; 490(-2-):163-179. >>> Uridine, bromodeoxy-; IP; Rat; 2ML2; 14 days; Labeling of subventricular zone (SVZ).

P7296 Budak,M.T., Alpdogan,O.S., Zhou,M.Y., Lavker,R.M., Akinci,M.A.M., Wolosin,J.M. Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. Journal of Cell Science 2005; 118(-8-):1715-1724. >>> Uridine, bromodeoxy-; SC; Rabbit; 2ML2; 14-16 days; Labeling of the ocular surface.

P7269 Huss,W.J., Gray,D.R., Greenberg,N.M., Mohler,J.L., Smith,G.J. Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells. Cancer Research 2005; 65(-15-):6640-6650. >>> Uridine, bromodeoxy-; Mice (transgenic); 2002; 2 weeks; Cancer (prostate); labeling of the prostate.

P7240 Hayashi,S., Asahara,T., Masuda,H., Isner,J.M., Losordo,D.W. Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization. Circulation 2005; 111(-17-):2210-2218. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; cardiovascular; ischemia (hindlimb).

P7239 Farah,M.H., Easter,SS Jr. Cell birth and death in the mouse retinal ganglion cell layer. Journal of Comparative Neurology 2005; 489(-1-):120-134. >>> Uridine, bromodeoxy-; SC; Mice (pregnant); 2001; 1-7 days; Teratology.

P7232 Karam,S.M., John,R., Alpers,D.H., Ponery,A.S. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23(-3-):433-441. >>> Retinoic acid; uridine, bromodeoxy-; SC; Mice; 1, 3, 6 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; cancer (gastric); multiple pumps per animal (2).

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