Recent References on Cell Proliferation Studies Using ALZET^® Osmotic Pumps

1. Thymidine (Studies From 2000-2011)

Q0381 Zhao,M., Lang,A.M.J. Bromodeoxyuridine infused into the cerebral ventricle of adult mice labels nigral neurons under physiological conditions-A method to detect newborn nerve cells in regions with a low rate of neurogenesis. Journal of Neuroscience Methods 2009; 184(-2-):327-331. >>> Uridine, bromodeoxy; thymidine, 3H; PBS; NaOH; CSF/CNS; IP; Mice; 2004; 1003D; ; Animal info (adult, male, C57BL/6, 10 wks old); labeling of neurons; ALZET brain infusion kit used.

P9319 DeAngelo,A.B., Daniel,F.B., Wong,D.M., George,M.H. The induction of hepatocellular neoplasia by trichloroacetic acid administered in the drinking water of the male B6C3F1 mouse. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 2008; 71(-16-):1056-1068. >>> Uridine, bromodeoxy-; thymidine, 3H-; SC; Mice; 2001; 5 days; Cancer (hepatic); toxicology; animal info (B6C3F1, male, 7-107 wks old).

P9129 Rodriguez,R., Hansen,L.T., Phear,G., Scorah,J., Spang-Thomsen,M., Cox,A., Helleday,T., Meuth,M. Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11. Clinical Cancer Research 2008; 14(-17-):5476-5483. >>> Thymidine; Saline; SC; Mice (nude); 2001; ; Controls received vehicle IP; animal info (male, 6 wks old, athymic, nu/nu).

P8464 Zhao,M., Momma,S., Delfani,K., Carlen,M., Cassidy,R.M., Johansson,C.B., Brismar,H., Shupliakov,O., Frisen,J., Janson,A.M. Evidence for neurogenesis in the adult mammalian substantia nigra. Proc.Natl.Acad.Sci.U.S.A 2003/6/24; 100(-13-):7925-7930. >>> Uridine, bromodeoxy-; thymidine, 3H; Ara-C; Saline, radio-isotopes; CSF/CNS; IP; Mice; 1003D; 1002; 2004; 2,3,10,14,21 days; Comparison of oral administration vs. IP injections; animal info (male, C57BL/6, 2-20 months old); neurodegenerative (Parkinson's disease); "the blood brain barrier and or peripheral metabolism limit the availability of BrdUrd in the brain." (p. 7929).

P7963 Rubel,E.W., Dew,L.A. Mammalian Vestibular Hair Cell Regeneration. Science 1995; 267(-5198-):701-707. >>> Thymidine; 3H tracer; radio-isotopes; Ear (semicircular canal); Guinea-pig; 2002; 2,4,6 weeks; Functionality of mp verified by scintillation counts of perilymph of the ear; long-term study; pumps replaced every two weeks; ALZET brain infusion kit used; animal info (albino, 300-400 g); Vetbond adhesive used to close skin; tissue perfusion (semicircular canal).

P7962 Corwin,J.T., Cotanche,D.A. Regeneration of Sensory Hair Cells after Acoustic Trauma. Science 1988; 240(-4860-):1772-1774. >>> Thymidine; 3H tracer; radio-isotopes; SC; Bird (chicken); 7-10 days; Comparison of IM injections vs. mp; multiple pumps per animal (2); animal info (white, leghorn, 9-13 days old).

P7703 Van Miller,J.P., Garman,R.H., Hermansky,S.J., Mirsalis,J.C., Frederick,C.B. Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate. Regul.Toxicol.Pharmacol. 2003/2; 37(-1-):54-65. >>> Uridine, bromodeoxy-; thymidine, 3H methyl-; PBS, dulbecco's; IP; Mice; 1003D; 2001D; 24 hours; Animal info (male wistar).

P7532 Helander,H.F., Li,H. Cell proliferation in the gastric epithelium of the ulcer rat. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2005; 40(-12-):1386-1393. >>> Thymidine; gastrin-17, synthetic rat; Saline; BSA; SC; Rat; 2ML1; 2ML2; 1, 2, 6, 13 days; Controls received mp w/ agent and no induced ulcer; functionality of mp verified by plasma gastrin levels; multiple pumps per animal (2); animal info (female, Sprague-Dawley, 200-250 g); mp primed overnight in 37C s.

P7500 Lotinun,S., Sibonga,J.D., Turner,R.T. Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts. Endocrinology 2005; 146(-9-):4074-4081. >>> Parathyroid hormone, human 1-34; thymidine, methyl -3H; Sodium chloride; HCl; serum, rat; ethanol; SC; Rat; 1, 2, 4 weeks; 1, 3, 5 days; Controls received mp w/ vehicle; functionality of mp verified by serum PTH; pumps replaced after 2 weeks; stability verified; peptides; multiple pumps per animal (2); animal info (female, Sprague-Dawley, 260 g); 2% ethanol.

P7340 Thompson,C.K., Brenowitz,E.A., Thompson,C.K. Seasonal change in neuron size and spacing but not neuronal recruitment in a basal ganglia nucleus in the avian song control system. Journal of Comparative Neurology 2005; 481(--):276-283. >>> Thymidine, [3H]; SC; Bird (song sparrow); 1007D; 7 days.

P6496 Helander,H.F., Poorkhalkali,N. Parietal cell density during gastric ulcer healing in the rat. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2004; 39(-1-):20-26. >>> Thymidine, (methyl-3H)-; gastrin-17, synthetic rat; Saline; BSA; SC; Rat; 2ML1; 2ML2; 1,2,6,13 days; Functionality of mp verified by gastrin plasma concentrations; multiple pumps per animal (2); mp primed overnight in saline @ 37 degrees Celsius.

P5684 Chouaf-Lakhdar,L., Fevre-Montange,M., Brisson,C., Strazielle,N., Gamrani,H., Didier-Bazes,M. Proliferative activity and nestin expression in periventricular cells of the adult rat brain. NeuroReport 2003; 14(-4-):633-636. >>> Uridine, bromodeoxy-; thymidine; Saline; NaOH (sodium hydroxide); Radio-Isotopes; 3H tracer; CSF/CNS; Rat; 1003D; 3 days; Brain tissue distribution.

P5644 Poorkhalkali,N., Helander,H.F. Cell kinetics of the oesophageal epithelium in the rat: Effects of hypergastrinaemia. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 2003; 38(-1-):14-19. >>> Gastrin-17; thymidine; Saline; BSA; radio-isotopes; 3H tracer; SC; Rat; 2ML1; 2ML2; 24 hrs; 6,9,15,17 days; Comparison of acute injections vs. mp; pumps replaced after 13 days in some groups; multiple pumps per animal (2) in one group (one with each agent); gastrin dissolved in saline w/ BSA.

P5334 Park,D.L., Girod,D.A., Durham,D. Avian brainstem neurogenesis is stimulated during cochlear hair cell regeneration. Brain Research 2002; 949(-1-2-):1-10. >>> Thymidine; 3H Tracer; Radio-isotopes; IP; Bird (chicken); 2001; 14 days; Pumps replaced after 7 days.

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2. Uridine, Bromodeoxy

P9832 Martins,K.J.B., Murdoch,G.K., Shu,Y., Harris,R.L.W., Gallo,M., Dixon,W.T., Foxcroft,G.R., Gordon,T., Putman,C.T. Satellite cell ablation attenuates short-term fast-to-slow fibre type transformations in rat fast-twitch skeletal muscle. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2009; 458(-2-):325-335. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 10 days; Pumps replaced after 1 week; animal info (adult, male, Wistar, 320 g.).

P9793 Makino,T., Ishikawa,K., Igarashi,I., Yamoto,T., Manabe,S., Nakayama,H. Relationship between GST Yp Induction and Hepatocyte Proliferation in Rats Treated with Phase II Drug Metabolizing Enzyme Inducers. Toxicologic Pathology 2008; 36(-3-):420-427. >>> Uridine, bromodeoxy-; DMSO; SC; Rat; 2001; 3, 7 days; Animal info (male, F344/DuCrj); 40% DMSO used.

P9781 Masunaga,S.I., Ando,K., Uzawa,A., Hirayama,R., Furusawa,Y., Koike,S., Ono,K. The radiosensitivity of total and quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo. Acta Oncologica 2008; 47(-6-):1087-1093. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 5 days; Animal info (8-11 wks old, syngenic, female, C3H/He); labelling of P cells.

P9692 Masunaga,S., Hirayama,R., Uzawa,A., Kashino,G., Suzuki,M., Kinashi,Y., Liu,Y., Koike,S., Ando,K., Ono,K. The effect of post-irradiation tumor oxygenation status on recovery from radiation-induced damage in vivo: with reference to that in quiescent cell populations. Journal of Cancer Research and Clinical Oncology 2009; 135(-8-):1109-1116. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 5 days; Cancer; animal info (9 wks old, female, syngenic, C3H/He).

P9678 Tharappel,J.C., Lehmler,H.J., Srinivasan,C., Robertson,L.W., Spear,B.T., Glauert,H.P. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food and Chemical Toxicology 2008; 46(-11-):3467-3474. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 3 days; Animal info (female, weanling, Sprague Dawley); labeling of hepatocyte.

P9657 Olabisi,R., Chamberlain,C.S., Petr,S., Steiner,S., Consigny,D., Best,T.M., Vanderby,R.Jr, Schultz,E., Noonan,K.J. The Effects of Botulinum Toxin A on Muscle Histology during Distraction Osteogenesis. Journal of Orthopaedic Research 2009; 27(-3-):310-317. >>> Uridine, bromodeoxy-; DMSO; water; SC; Rabbit; 2ML4; 8 weeks; Pumps replaced after 4 wks; animal info (New England, Sheletalby, mature, 3.3-3.9).

P9650 Hayashi,S., Fujii,E., Kato,A., Kimura,K., Mizoguchi,K., Suzuki,M., Sugimoto,T., Takanashi,H., Itoh,Z., Omura,S., Wanibuchi,H. Characterization of Multinuclear Hepatocytes Induced in Rats by Mitemcinal (GM-611), an Erythromycin Derivative. Toxicologic Pathology 2008; 36(-6-):858-865. >>> Uridine, bromodeoxy-; DMSO; water, distilled; IP; Rat; 2002; 28 days; Pumps replaced after 14 days; animal info (SD, female); multiple pumps per animal (2); 50% DMSO.

P9645 Deguchi,Y., Yamada,T., Hirose,Y., Nagahori,H., Kushida,M., Sumida,K., Sukata,T., Tomigahara,Y., Nishioka,K., Uwagawa,S., Kawamura,S., Okuno,Y. Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation. TOXICOLOGICAL SCIENCES 2009; 108(-1-):69-80. >>> Uridine, bromodeoxy-; SC; Rat; 7 days; Animal info (male, female, 9 wks old).

P9591 Khan,M.D.H., Klein,D., Mossbrugger,I., Oesterle,D., Csanady,G.A., Quintanilla-Martinez,L., Filser,J.G. Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol?. TOXICOLOGY LETTERS 2009; 185(-3-):203-210. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; ; Animal Info (male, Fischer, 238g).

P9576 Jeong,J.O., Kim,M.O., Kim,H., Lee,M.Y., Kim,S.W., Ii,M., Lee,J.U., Lee,J., Choi,Y.J., Cho,H.J., Lee,N., Silver,M., Wecker,A., Kim,D.W., Yoon,Y.S. Dual Angiogenic and Neurotrophic Effects of Bone Marrow-Derived Endothelial Progenitor Cells on Diabetic Neuropathy. Circulation 2009; 119(-5-):699-U93. >>> Uridine, bromodeoxy-; SC; Mice; 4 weeks; Animal info (C57BL/6J, 6 wks old, male).

P9546 Zhang,W., Zhao,J., Chen,L., Urbanowicz,M.M., Nagasaki,T. Abnormal epithelial homeostasis in the cornea of mice with a destrin deletion. MOLECULAR VISION 2008; 14(-228-):1929-1939. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 2002; 2 weeks; 24 hours; Animal info (GFP-Dstn Corn1, 13-20 wks old).

P9534 Masunaga,S., Tano,K., Watanabe,M., Kashino,G., Suzuki,M., Kinashi,Y., Ono,K., Nakamura,J. Evaluation of the potential of hexamethylenetetramine, compared with tirapazamine, as a combined agent with gamma-irradiation and cisplatin treatment in vivo. British Journal of Radiology 2009; 82(-977-):392-400. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; ; Animal info (female, syngenic, 22g).

P9429 Masunaga,S.I., Ando,K., Uzawa,A., Hirayama,R., Furusawa,Y., Koike,S., Ono,K. Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo. Radiation Medicine 2008; 26(-5-):270-277. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old).

P9387 Andersen,M.E., Clewell,HJ III, Bermudez,E., Willson,G.A., Thomas,R.S. Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat. TOXICOLOGICAL SCIENCES 2008; 105(-2-):368-383. >>> Uridine, bromodeoxy; Rat; 2ML1; 3 days; Toxicology; animal info (male, F344/CrlBR, 8-10 wks old, 200 g.).

P9349 Luque,R.M., Soares,B.S., Peng,X.D., Krishnan,S., Cordoba-Chacon,J., Frohman,L.A., Kineman,R.D. Use of the Metallothionein Promoter-Human Growth Hormone-Releasing Hormone (GHRH) Mouse to Identify Regulatory Pathways that Suppress Pituitary Somatotrope Hyperplasia and Adenoma Formation due to GHRH-Receptor Hyperactivation. Endocrinology 2009; 150(-7-):3177-3185. >>> Uridine, bromodeoxy; SC; Mice (transgenic); 72 hours; Animal info (Tg, 4 months old); dose (20 mg/ml).

P9319 DeAngelo,A.B., Daniel,F.B., Wong,D.M., George,M.H. The induction of hepatocellular neoplasia by trichloroacetic acid administered in the drinking water of the male B6C3F1 mouse. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 2008; 71(-16-):1056-1068. >>> Uridine, bromodeoxy-; thymidine, 3H-; SC; Mice; 2001; 5 days; Cancer (hepatic); toxicology; animal info (B6C3F1, male, 7-107 wks old).

P9303 Rivers,L.E., Young,K.M., Rizzi,M., Jamen,F., Psachoulia,K., Wade,A., Kessaris,N., Richardson,W.D. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nature Neuroscience 2008; 11(-12-):1392-1401. >>> Uridine, bromodeoxy-; Ammonium solution; SC; Mice (transgenic); 17 days; Controls received mp w/ vehicle; comparison of oral vs. mp; pumps replaced after 9 days; animal info (BAC Tg/Pdfra-cre ER-T2/Rosa 26-YFP, 60 days old).

P9243 Lutgens,E., Tjwa,M., de Frutos,P.G., Wijnands,E., Beckers,L., Dahlbaeck,B., Daemen,M.J.A.P., Carmeliet,P., Moons,L. Genetic loss of Gas6 induces plaque stability in expeximental atherosclerosis. Journal of Pathology 2008; 216(-1-):55-63. >>> Uridine, bromodeoxy-; Mice; 2001; 2 weeks; Cardivascular; animal info (C57/BL6 x 129/sv x Swiss Gas6 -/-: ApoE -/-, Gas6 +/+: ApoE -/-; 23 wks old).

P9214 Newberry,E.P., Kennedy,S.M., Xie,Y., Luo,J., Stanley,S.E., Semenkovich,C.F., Crooke,R.M., Graham,M.J., Davidson,N.O. Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology 2008; 48(-4-):1097-1105. >>> Uridine, bromodeoxy-; uridine, fluorodeoxy-; Mice; 1003D; 48, 72 hours; Partial hepatectomy; animal info (10-20 wks old, C57BL/6, PLDKO, PPARa -/-, FAS-KOL, L-Fabp -/-, MTP-IKO).

P9128 Schmiedl,A., Lempa,T., Hoymann,H.G., Rittinghausen,S., Popa,D., Tschernig,T., Fehrenbach,H., Pabst,R., Hoeper,M.M., Hohlfeld,J.M. Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally. VIRCHOWS ARCHIV 2008; 452(-6-):675-688. >>> Uridine, bromodeoxy; SC; Rat; ; Animal info (male, Lewis, 195-230 g.); 2 ml pump used.

P9057 Masunaga,S., Sakurai,Y., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Nagasawa,H., Uto,Y., Hori,H., Ono,K. The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons. British Journal of Radiology 2006; 79(-948-):991-998. >>> Uridine, bromodeoxy-; tirapazamine; Saline; SC; Mice; 2001D; 5 days; 24 hours; Tissue perfusion (tumor); comparison of IP injections vs. mp; cancer; animal info (8-11 wks old, female, syngenic C3H, He); tirapazamine, also known as TP2, is a lead compound as a bioreactive hypoxic cytotoxin; labing of P cells; cancer.

P9047 Oslund,K.L., Hyde,D.M., Putney,L.F., Alfaro,M.F., Walby,W.F., Tyler,N.K., Schelegle,E.S. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. American Journal of Respiratory Cell and Molecular Biology 2008; 39(-3-):279-288. >>> SR140333; Uridine, bromodeoxy-; Saline, sterile; SC; IV (jugular); Rat; 2001D; 2ML2; ; Controls received mp w/ vehicle; good methods (pg. 280); animal info (male, Wistar); pumps were primed for 3 hours; polyethylene tubing used; incisions were closed with 7.5 mm steel wound clips.

P8983 Ott,T., Jokwitz,M., Lenhard,D., Romualdi,A., Dombrowski,F., Ittrich,C., Schwarz,M., Willecke,K. Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis. European Journal of Cell Biology 2006; 85(-8-):717-728. >>> Uridine, bromodeoxy-; Mice; 1003D; 3 days; Cancer (breast, liver); animal info (male, C57BL/6-129sv, wt, Cx32 -/-, Cx26, FL/FL, Cx26 FL/FL:AlfpCre); "BrdU was applied by osmotic pumps over a period of 3 days to avoid diurnal variation in proliferation." (p. 720).

P8982 Masunaga,S.I., Nagasawa,H., Sakurai,Y., Uto,Y., Hori,H., Nagata,K., Suzuki,M., Maruhashi,A., Kinashi,Y., Ono,K. The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy. International Journal of Hyperthermia 2006; 22(-4-):287-299. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old).

P8963 Sadeu,J.C., Adriaens,I., Cortvrindt,R., Smitz,J. Study of folliculogenesis in vivo in guinea pig. Theriogenology 2007; 68(-9-):1228-1239. >>> Uridine, bromodeoxy; Saline; SC; Guinea-pig; 2ML1; 1, 2 weeks; Animal info (female, Dunkin-Hartley, 560-750).

P8898 Maeshima,A., Sakurai,H., Nigam,S.K. Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. Journal of the American Society of Nephrology 2006; 17(-1-):188-198. >>> Uridine, bromodeoxy-; IP; Rat; 1 week; Animal info (male, Sprague Dawley, 7 wks old, 240 g.); ischemia (kidney); nephrology.

P8885 Tharappel,J.C., Spear,B.T., Glauert,H.P. Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-kappaB. TOXICOLOGY AND APPLIED PHARMACOLOGY 2008; 226(-3-):338-344. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 3 days; Animal info (7-8 wks old, B6129, p50 -/-).

P8868 Mziaut,H., Kersting,S., Knoch,K.P., Fan,W.H., Trajkovski,M., Erdmann,K., Bergert,H., Ehehalt,F., Saeger,H.D., Solimena,M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008; 105(-2-):674-679. >>> Uridine, bromodeoxy-; DMSO; IP; Mice; 1007D; 7 days; Animal info (ICA 512 -/-); 50% DMSO used; diabetes.

P8813 Kubota,Y., Takubo,K., Suda,T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochemical and Biophysical Research Communications 2008; 366(-2-):335-339. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2004; 2 months; Long-term study; pumps replaced after 28 days; multiple pumps per animal (2); animal info (C57BL/6, 1 month old); labeling of bone marrow LRC's.

P8788 Ray,J.B., Arab,S., Deng,Y., Liu,P., Penn,L., Courtman,D.W., Ward,M.E. Oxygen regulation of arterial smooth muscle cell proliferation and survival. American Journal of Physiology-Heart and Circulatory Physiology 2008; 294(-2-):H839-H852. >>> Uridine, bromodeoxy-; DMSO; SC; Rat; 2ML2; 48 hours; Animal info (male, Sprague Dawley, 175-200 g.); 0.4% DMSO used.

P8763 Lassmann,J., Sliwoski,J., Chang,A., Canning,D.A., Zderic,S.A. Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008; 294(-1-):R58-R65. >>> Uridine, bromodeoxy-; Carbonate solution; SC; Mice; 2004; 4 weeks; Animal info (male, SERCA2, partial bladder outlet obstruction, 8 wks old).

P8729 Masunaga,S., Takahashi,A., Ohnishi,K., Nagata,K., Suzuki,M., Kashino,G., Kinashi,Y., Ohnishi,T., Ono,K. Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population. Oncology Reports 2007; 18(-6-):1589-1596. >>> Uridine, bromodeoxy-; Saline; SC; Mice (nude); 2001; 7 days; Tissue perfusion (tumor); cancer; animal info (Balb/cA, nude); labeling of tumor cells.

P8727 Hsieh,P.C.H., Segers,V.F.M., Davis,M.E., MacGillivray,C., Gannon,J., Molkentin,J.D., Robbins,J., Lee,R.T. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Medicine 2007; 13(-8-):970-974. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 7 days; Animal info (adult, transgenic, MerCreMer-ZEG); labeling of cardiomyocytes.

P8716 Bunaciu,R.P., Tharappel,J.C., Lehmler,H.J., Kania-Korwel,I., Robertson,L.W., Srinivasan,C., Spear,B.T., Glauert,H.P. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 2007; 239(-3-):147-155. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; ; Toxicology; animal info (female, Sprague-Dawley, 100-125g); labeling of hepatocytes.

P8691 Martin,C.D., Jimenez-Andrade,J.M., Ghilardi,J.R., Mantyh,P.W. Organization of a unique net-like meshwork of CGIZP+ sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain. Neuroscience Letters 2007; 427(-3-):148-152. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 24 hours; Animal info (C57BL/6J, 18-25g, male); bone; pain; labeling at the periosteum.

P8566 Virag,J.A.I., Rolle,M.L., Reece,J., Hardouin,S., Feigl,E.O., Murry,C.E. Fibroblast growth factor-2 regulates myocardial infarct repair - Effects on cell proliferation, scar contraction, and ventricular function. American Journal of Pathology 2007; 171(-5-):1431-1440. >>> Uridine, bromodeoxy-; DMSO; water; SC; Mice (knockout); 1007D; 4 days; Cardiovascular; animal info (FGF2 knockout mice, 6-8 weeks old, 20-30 grams); 50% DMSO 50% water; labeling of endothelial cells.

P8535 Gordon,S.E., Westerkamp,C.M., Savage,K.J., Hickner,R.C., George,S.C., Fick,C.A., McCormick,K.M. Basal, but not overload-induced, myonuclear addition is attenuated by NG-initro-L-arginine methyl ester (L-NAME) administration. Canadian Journal of Physiology and Pharmacology 2007; 85(-6-):646-651. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Animal info (female, Sprague-Dawley, 220 g).

P8522 Kim,I., Morimura,K., Shah,Y., Yang,Q., Ward,J.M., Gonzalez,F.J. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007; 28(-5-):940-946. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 1 week; Animal info (C57NL/6N, wt, Fxr-null; 3,12 months old).

P8502 Yang,Q., Ito,S., Gonzalez,F.J. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis 2007/6; 28(-6-):1171-1177. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2001; 1 week; labeling of hepatocytes; animal info (transgenic).

P8348 Rudnick,D.A., Shikapwashya,O., Blomenkamp,K., Teckman,J.H. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology 2006; 44(-4-):976-982. >>> Uridine, bromodeoxy-; IP; Mice; 72 hours; Animal info (male, C57BL/6J-piz, 6-12 months old).

P8308 Price,R.J., Walters,D.G., Finch,J.M., Gabriel,K.L., Capen,C.C., Osimitz,T.G., Lake,B.G. A mode of action for induction of liver tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2007; 218(-2-):186-195. >>> Uridine, bromodeoxy-; Rat; 2ML1; 7 days; Cancer (liver); toxicology; animal info (male, female, Sprague-Dawley CD, 10-11 wks old); labeling of hepatocytes.

P8209 Masunaga,S.I., Kasaoka,S., Maruyama,K., Nigg,D., Sakurai,Y., Nagata,K., Suzuki,M., Kinashi,Y., Maruhashi,A., Ono,K. The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2006; 66(-5-):1515-1522. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old, 20-25g.).

P8203 Masunaga,S., Nagasawa,H., Nagata,K., Suzuki,M., Uto,Y., Hori,H., Kinashi,Y., Ono,K. Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells. Journal of Cancer Research and Clinical Oncology 2007; 133(-1-):47-55. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5, 8 days; Cancer (carcinoma); animal info (female, 8-11 wks old).

P8169 Masunaga,S.I., Uto,Y., Nagasawa,H., Hori,H., Nagata,K., Suzuki,M., Kinashi,Y., Ono,K. Evaluation of hypoxic cell radio-sensitizers in terms of radio-sensitizing and repair-inhibiting potential. dependency on p53 status of tumor cells and the effects on intratumor quiescent cells. Anticancer Research 2006; 26(-2A-):1261-1270. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice (nude); 5, 7 days; Cancer (squamous cell carcinoma); animal info (BALB/cA, C3H/He, 6-7 weeks old, 22 grams); labeling of tumor 'P' cells.

P8135 Finch,J.M., Osimitz,T.G., Gabriel,K.L., Martin,T., Henderson,W.J., Capen,C.C., Butler,W.H., Lake,B.G. A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2006; 214(-3-):253-262. >>> Uridine, bromodeoxy-; 2ML1; 7, 14 days; Pumps replaced after 7 days; animal info (male, female, Sprague-Dawley CD, 10-11 wks old, 450-500g., 250-300g.).

P8099 Bernstein,D.M., Rogers,R., Smith,P., Chevalier,J. The toxicological response of Brazilian chrysotile asbestos: A multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response. INHALATION TOXICOLOGY 2006; 18(-5-):313-332. >>> Uridine, bromodeoxy-; SC; Rat; 2001; 3 days; Toxicology; animal info (male, Wistar Han-Ibm, 9 wk old).

P8068 Cafaro,J., Lee,G.S., Stone,J.S. Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration. Developmental Dynamics 2007; 236(-1-):156-170. >>> Uridine, bromodeoxy-; PBS; Ear (perilymphatic fluid); Bird (chicken); 2002; 8 days; No stress (see p.167); Alzet brain infusion kit used; animal info (White Legorn, 5-10 days old).

P7991 Vogetseder,A., Palan,T., Bacic,D., Kaissling,B., Le Hir,M. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2007; 292(-2-):C807-C813. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 1, 2 weeks; Pumps replaced every 7 days for two week studies; animal info (male, Wistar, 4-5 weeks old, 110-140 grams); labeling of kidney.

P7930 Voss,K.A., Riley,R., Dunn,C., Corton,J.C. The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. Toxicology 2006; 222(-3-):165-174. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; animal info (male, 1.5 weeks old); labeling of hepatocytes.

P7887 Dedkov,E.I., Zheng,W., Tomanek,R.J. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. American Journal of Physiology-Heart and Circulatory Physiology 2006; 291(-4-):H1686-H1693. >>> Uridine, bromodeoxy-; Rat; 72 hours; Cardiovascular; animal info (male, Sprague-Dawley, 12 month old); left coronary artery ligation to induce MI; labeling of coronary arterioles (endothelial cells of the coronary arterioles).

P7801 Overstreet-Wadiche,L.S., Bromberg,D.A., Bensen,A.L., Westbrook,G.L. Seizures accelerate functional integration of adult-generated granule cells. Journal of Neuroscience 2006; 26(-15-):4095-4103. >>> Uridine, bromodeoxy-; Saline; NaOH; SC; Mice (transgenic); 2001D; 1 day; Animal info (adult, -13/+8POMC-EGFP Tg.); labeling of granule cells.

P7796 Martins,K.J.B., Gordon,T., Pette,D., Dixon,W.T., Foxcroft,G.R., MacLean,I.M., Putman,C.T. Effect of satellite cell ablation on low-frequency-stimulated fast-to-slow fibre-type transitions in rat skeletal muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 572(-1-):281-294. >>> Uridine, bromodeoxy-; SC; Rat; 2004; 21 days; Animal info (male, Wistar, 296g.); labeling of satellite cells.

P7794 Schrier,L., Ferns,S.P., Barnes,K.M., Emons,J.A.M., Newman,E.I., Nilsson,O., Baron,J. Depletion of resting zone chondrocytes during growth plate senescence. Journal of Endocrinology 2006; 189(-1-):27-36. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Rabbit; rabbit (pregnant); 2ML1; 1 week; Controls did not receive BrdU; animal info (New Zealand White, male; 5, 9&17 wk. old, female, pregnant); endocrinology; labeling of chondocytes.

P7786 Pauluhn,J., Mohr,U. Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose-only inhalation study in rats. Journal of Applied Toxicology 2006; 26(-3-):279-292. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 7 days; Animal info (male, Wistar, 5 months old); labeling of lung cells (alveolar, epithelial).

P7738 Hyatt,J.P.K., Roy,R.R., Baldwin,K.M., Wernig,A., Edgerton,V.R. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle&Nerve 2006; 33(-1-):49-60. >>> Uridine, bromodeoxy-; SC; Rat; 2ML2; 14 days; Animal info (female, Sprague-Dawley, 200-235g.; denervation or spinal cord isolation); labeling of satellite cells.

P7671 Campbell,J.S., Riehle,K.J., Brooling,J.T., Bauer,R.L., Mitchell,C., Fausto,N. Proinflammatory cytokine production in. liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. Journal of Immunology 2006; 176(-4-):2522-2528. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 48 hours; Comparison of IP injection vs. mp; animal info (C57BL/6, KO, heterozygous, male, 11 wk old); labeling of hepatocytes.

P7623 Ohyama,M., Terunuma,A., Tock,C.L., Radonovich,M.F., Pise-Masison,C.A., Hopping,S.B., Brady,J.N., Udey,M.C., Vogel,J.C. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. Journal of Clinical Investigation 2006; 116(-1-):249-260. >>> Uridine, bromodeoxy-; SC; Mice (nude); 1002; 4-6 weeks; Pumps replaced every 2 weeks; multiple pumps per animal (2).

P7510 Voss,K.A., Liu,J., Anderson,S.P., Dunn,C., Miller,J.D., Owen,J.R., Riley,R.T., Bacon,C.W., Corton,J.C. Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. TOXICOLOGICAL SCIENCES 2006; 89(-1-):108-119. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; No stress (see pg. 111); animal info (female, SV129, 20-22 g); labeling of hepatocytes.

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